NIH PAS · NIDDK · R01

PAS-25-205: Stimulating Hematology Investigation: New Endeavors (SHINE) (R01 Clinical Trial Not Allowed)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Feb 5, 2027Expires Jan 7, 2028

The Stimulating Hematology Investigation: New Endeavors (SHINE) program is intended to promote innovative, high-quality nonmalignant hematology research relevant to the missions of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institute of Aging (NIA), and the National Heart, Lung, and Blood Institute (NHLBI). Investigator-initiated research project grant applications (R01s) in specific areas of basic and early translational hematology research are invited to this program that supports growth in the nonmalignant hematology research domain. Specific emerging topics that are at the leading edge of the field will change over time and will be updated…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAS-25-205
Type
PAS
Activity code
R01
Primary institute
NIDDK · National Institute of Diabetes and Digestive and Kidney Diseases
Clinical trials
Not Allowed
Posted
Nov 6, 2024
Opens
Jan 5, 2025
Expires
Jan 7, 2028

PAS-25-205 due dates

3 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAS-25-205
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
February 05, 2025March 05, 2025 *Not ApplicableJuly 2025October 2025December 2025
June 05, 2025July 05, 2025 *Not ApplicableNovember 2025January 2026April 2026
October 05, 2025November 05, 2025 *Not ApplicableMarch 2026May 2026July 2026
February 05, 2026March 05, 2026 *Not ApplicableJuly 2026October 2026December 2026
June 05, 2026July 05, 2026 *Not ApplicableNovember 2026January 2027April 2027
October 05, 2026November 05, 2026 *Not ApplicableMarch 2027May 2027July 2027
February 05, 2027March 05, 2027 *Not ApplicableJuly 2027October 2027December 2027
June 05, 2027July 05, 2027 *Not ApplicableNovember 2027January 2028April 2028
October 05, 2027November 05, 2027 *Not ApplicableMarch 2028May 2028July 2028

Projects funded under PAS-25-205

NIH RePORTER lists 27 projects funded under PAS-25-205 in FY2022–FY2026, with $18.3M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

27

Distinct projects, FY2022–FY2026

New awards

19

Type 1 (new project) award records

NIH funding

$18.3M

Award dollars under PAS-25-205, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAS-25-205
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY20262719$18.3M

Institutions with the most funding

  1. University of Wisconsin-Madison$3.0M · 5 projects
  2. University of Tx MD Anderson Can Ctr$1.6M · 1 project
  3. Children's Hosp of Philadelphia$1.6M · 2 projects
  4. St. Jude Children's Research Hospital$1.4M · 2 projects
  5. Cincinnati Childrens Hosp Med Ctr$1.4M · 2 projects
  6. Pennsylvania State University, the$1.1M · 2 projects
  7. Sloan-Kettering Inst Can Research$903K · 1 project
  8. Dana-Farber Cancer Inst$867K · 1 project

Funding institutes

  • NIDDK$10.2M · 16
  • NHLBI$6.8M · 9
  • NIA$1.2M · 2

Activity codes funded

  • R0124 records
  • R563 records

Most recent new awards

What its predecessor PAS-22-096 funded

PAS-25-205 reissues PAS-22-096. Its funding history is the best guide to who wins under this program: 66 projects and $84.9M in FY2022–FY2026.

Projects funded

66

Distinct projects, FY2022–FY2026

New awards

52

Type 1 (new project) award records

NIH funding

$84.9M

Award dollars under PAS-22-096, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAS-22-096
Fiscal yearAward recordsNew awardsFunding
FY202222$453K
FY20232920$11.2M
FY20244016$19.2M
FY20255714$27.8M
FY2026450$26.3M

Institutions with the most funding

  1. Cincinnati Childrens Hosp Med Ctr$6.6M · 4 projects
  2. Boston Children's Hospital$5.5M · 4 projects
  3. University of Wisconsin-Madison$4.8M · 4 projects
  4. Albert Einstein College of Medicine$4.7M · 3 projects
  5. Icahn School of Medicine at Mount Sinai$4.4M · 2 projects
  6. University of Pittsburgh at Pittsburgh$4.1M · 2 projects
  7. Yale University$4.0M · 3 projects
  8. St. Jude Children's Research Hospital$3.5M · 2 projects

Funding institutes

  • NIDDK$43.3M · 100
  • NHLBI$35.8M · 62
  • NIA$5.8M · 11

Activity codes funded

  • R01158 records
  • R5615 records

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

3 NIH institutes and offices take applications under PAS-25-205. Contact the program officer at the institute that fits your research before applying.

  • NIDDK · National Institute of Diabetes and Digestive and Kidney Diseases
  • NHLBI · National Heart, Lung, and Blood Institute
  • NIA · National Institute on Aging

Related notices

  1. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  2. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  3. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Award terms

Application types allowed
NewRenewalResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets are not limited but need to reflect the actual needs of the proposed project.
Project period
The scope of the proposed project should determine the project period.  The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
NIH intends to fund an estimated 5–8 awards beyond its regular/standard R01 funding policies, corresponding to a total of 2,500,000 in FY 2025. Future year amounts will depend on annual appropriations.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PAS-22-096.

Other open NOFOs for R01

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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