NIH PAS · NIDDK · R01
PAS-25-073: Priority HIV/AIDS Research within the Mission of NIDDK (R01 Clinical Trial Optional)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
This Notice of Funding Opportunity (NOFO) seeks to stimulate HIV/AIDS research within the mission of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) that align with the HIV/AIDS research priorities outlined by the NIH Office of AIDS Research (OAR). These priorities were most recently described in NOT-OD-20-018 UPDATE: NIH HIV/AIDS Research Priorities and Guidelines for Determining HIV/AIDS Funding.
- NOFO number
- PAS-25-073
- Type
- PAS
- Activity code
- R01
- Primary institute
- NIDDK · National Institute of Diabetes and Digestive and Kidney Diseases
- Clinical trials
- Optional
- Posted
- Jan 8, 2025
- Opens
- Apr 8, 2025
- Expires
- Nov 6, 2027
PAS-25-073 due dates
3 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| Not Applicable | Not Applicable | May 07, 2025 * | July 2025 | October 2025 | December 2025 |
| Not Applicable | Not Applicable | September 07, 2025 | November 2025 | January 2026 | April 2026 |
| Not Applicable | Not Applicable | January 07, 2026 * | March 2026 | May 2026 | July 2026 |
| Not Applicable | Not Applicable | May 07, 2026 * | July 2026 | October 2026 | December 2026 |
| June 05, 2026 * | July 05, 2026 * | Not Applicable | November 2026 | January 2027 | April 2027 |
| October 05, 2026 * | November 05, 2026 | Not Applicable | March 2027 | May 2027 | July 2027 |
| February 05, 2027 | March 05, 2027 * | Not Applicable | July 2027 | October 2027 | December 2027 |
| June 05, 2027 * | July 05, 2027 * | Not Applicable | November 2027 | January 2028 | April 2028 |
| October 05, 2027 * | November 05, 2027 | Not Applicable | March 2028 | May 2028 | July 2028 |
Projects funded under PAS-25-073
NIH RePORTER lists 6 projects funded under PAS-25-073 in FY2022–FY2026, with $4.5M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.
Projects funded
6
Distinct projects, FY2022–FY2026
New awards
6
Type 1 (new project) award records
NIH funding
$4.5M
Award dollars under PAS-25-073, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 0 | 0 | $0 |
| FY2026 | 6 | 6 | $4.5M |
Institutions with the most funding
- Texas Biomedical Research Institute$906K · 1 project
- Duke University$833K · 1 project
- Northwestern University$794K · 1 project
- Icahn School of Medicine at Mount Sinai$684K · 1 project
- University of Tennessee Knoxville$639K · 1 project
- University of Maryland Baltimore$618K · 1 project
Funding institutes
- NIDDK$4.5M · 6
Activity codes funded
- R015 records
- R561 record
Most recent new awards
- Regulation and Role of pDC in Immunopathogenesis of HBV/HIV co-Infection (opens NIH RePORTER)
University of Maryland Baltimore · 1R01DK149875-01 · NIDDK · Notice Sep 4, 2026
$618KR01
- Restoring α1,2-Fucose to Rebuild the Microbiota and Strengthen the Intestinal Barrier in HIV (opens NIH RePORTER)
Northwestern University · 1R01DK149864-01 · NIDDK · Notice Sep 2, 2026
$794KR01
- Epigenetic modulation of intestinal epithelial dysfunction in HIV/SIV infection (opens NIH RePORTER)
Texas Biomedical Research Institute · 1R01DK146767-01 · NIDDK · Notice Aug 26, 2026
$906KR01
- Strategies to promote HIV-to-HIV kidney transplantation through organ donation (opens NIH RePORTER)
University of Tennessee Knoxville · 1R56DK149809-01 · NIDDK · Notice Aug 24, 2026
$639KR56
- EYA1 as a novel regulator of HIV-induced end stage kidney disease (opens NIH RePORTER)
Icahn School of Medicine at Mount Sinai · 1R01DK146762-01 · NIDDK · Notice Feb 13, 2026
$684KR01
- Defining cellular and molecular signatures of inflammation in people with suppressed HIV that promote chronic kidney disease (opens NIH RePORTER)
Duke University · 1R01DK146765-01 · NIDDK · Notice Jan 22, 2026
$833KR01
What its predecessor PAS-24-163 funded
PAS-25-073 reissues PAS-24-163. Its funding history is the best guide to who wins under this program: 2 projects and $4.7M in FY2022–FY2026.
Projects funded
2
Distinct projects, FY2022–FY2026
New awards
2
Type 1 (new project) award records
NIH funding
$4.7M
Award dollars under PAS-24-163, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 2 | 2 | $3.9M |
| FY2026 | 1 | 0 | $824K |
Institutions with the most funding
- Indiana University Indianapolis$3.1M · 1 project
- Icahn School of Medicine at Mount Sinai$1.6M · 1 project
Funding institutes
- NIDDK$4.7M · 3
Activity codes funded
- R013 records
Most recent new awards
- HIV, Depression, and Insulin Resistance (opens NIH RePORTER)
Indiana University Indianapolis · 1R01DK141366-01A1 · NIDDK · Notice Aug 27, 2025
$3.1MR01
- Complex Autonomic Neuropathic Dysfunction Leading to Gastrointestinal and Immune Effects in People with HIV (CANDLE) (opens NIH RePORTER)
Icahn School of Medicine at Mount Sinai · 1R01DK143962-01 · NIDDK · Notice Aug 22, 2025
$789KR01
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
2 NIH institutes and offices take applications under PAS-25-073. Contact the program officer at the institute that fits your research before applying.
- NIDDK · National Institute of Diabetes and Digestive and Kidney Diseases
- none
Related notices
Jan 28, 2026 · NOT-OD-26-029
NIH Removing AIDS Application Due Dates from NOFOs.
Mar 31, 2025 · NOT-OD-24-084
This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Notices of Special Interest (NOSIs)
NIH has attached 1 NOSI to PAS-25-073; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.
Award terms
- Application types allowed
- NewRenewalResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets are not limited but need to reflect the actual needs of the proposed project.
- Project period
- The scope of the proposed project should determine the project period. The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- NIDDK intends to fund an estimate of 3 to 5 awards, corresponding to a total of 2,000,000, for fiscal year 2026. Future year amounts will depend on annual appropriations.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAS-24-163.
Other open NOFOs for R01
- PAS-25-205Stimulating Hematology Investigation: New Endeavors (SHINE) (R01 Clinical Trial Not Allowed)NIDDK · next due Feb 5, 2027
- PAR-25-379Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)NIDA · next due Oct 21, 2026
- PAR-25-322Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed)OD · next due Jan 26, 2027
- PA-25-301NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)NIH · next due Feb 5, 2027
- PA-25-305NIH Research Project Grant (Parent R01 Clinical Trial Required)NIH · next due Feb 5, 2027
- PAR-25-144Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)NCI · next due Feb 5, 2027
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.