NIH PAR · NICHD · UG3, UH3

PAR-25-311: Leveraging Network Infrastructure to Conduct Innovative Research for Women, Children, Pregnant and Lactating Women, and Persons with Disabilities (UG3/UH3 - Clinical Trial Optional)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Nov 13, 2026Expires Nov 16, 2027

The purpose of this Notice of Funding Opportunity (NOFO) is to leverage NICHD clinical research Network infrastructure relevant to infants, children, women, pregnant and lactating individuals, and persons with disabilities to conduct innovative, multisite, investigator-initiated clinical trials and observational studies. This NOFO will utilize a bi-phasic (UG3/UH3), milestone-driven mechanism consisting of a start-up phase (UG3) and a full enrollment and clinical trial implementation phase (UH3). Applications submitted in response to this NOFO must address specific aims and milestones for both the UG3 and UH3 phases. A UG3 project (phase I) that meets its milestones will be administratively…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-311
Type
PAR
Activity code
UG3UH3
Primary institute
NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
Clinical trials
Optional
Posted
Dec 16, 2024
Opens
Feb 15, 2025
Expires
Nov 16, 2027

PAR-25-311 due dates

4 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-311
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
March 14, 2025March 14, 2025March 14, 2025July 2025October 2025December 2025
July 15, 2025July 15, 2025July 15, 2025November 2025January 2026April 2026
November 14, 2025November 14, 2025November 14, 2025March 2026May 2026July 2026
March 15, 2026March 15, 2026March 15, 2026July 2026October 2026December 2026
July 15, 2026July 15, 2026Not ApplicableNovember 2026January 2027April 2027
November 13, 2026November 13, 2026Not ApplicableMarch 2027May 2027July 2027
March 15, 2027March 15, 2027Not ApplicableJuly 2027October 2027December 2027
July 15, 2027July 15, 2027Not ApplicableNovember 2027January 2028April 2028
November 15, 2027November 15, 2027Not ApplicableMarch 2028May 2028July 2028

Projects funded under PAR-25-311

NIH RePORTER lists 2 projects funded under PAR-25-311 in FY2022–FY2026, with $3.0M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

2

Distinct projects, FY2022–FY2026

New awards

2

Type 1 (new project) award records

NIH funding

$3.0M

Award dollars under PAR-25-311, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-311
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY202622$3.0M

Institutions with the most funding

  1. Research Triangle Institute$2.0M · 1 project
  2. George Washington University$1.1M · 1 project

Funding institutes

  • NICHD$3.0M · 2

Activity codes funded

  • UG32 records

Most recent new awards

What its predecessor PAR-23-037 funded

PAR-25-311 reissues PAR-23-037. Its funding history is the best guide to who wins under this program: 5 projects and $23.5M in FY2022–FY2026.

Projects funded

5

Distinct projects, FY2022–FY2026

New awards

5

Type 1 (new project) award records

NIH funding

$23.5M

Award dollars under PAR-23-037, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-23-037
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202422$4.4M
FY202553$8.9M
FY202650$10.2M

Institutions with the most funding

  1. George Washington University$19.0M · 3 projects
  2. Research Triangle Institute$4.5M · 2 projects

Funding institutes

  • NICHD$23.5M · 12

Activity codes funded

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under PAR-25-311. Contact the program officer at the institute that fits your research before applying.

  • NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
  • ORWH

Related notices

  1. Jan 28, 2026 · NOT-OD-26-029

    NIH Removing AIDS Application Due Dates from NOFOs.

  2. May 20, 2025 · NOT-HD-25-002

    Notice Announcing Webinar and Frequently Asked Questions FAQs) for PAR-25-311 Leveraging Network Infrastructure to Conduct Innovative Research for Women, Children, Pregnant and Lactating Women, and Persons with Disabilities.

  3. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  4. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  5. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Notices of Special Interest (NOSIs)

NIH has attached 1 NOSI to PAR-25-311; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.

Award terms

Application types allowed
NewRenewalResubmission Renewals will be considered on a case-by-case basis and will require NICHD approval prior to submission. Renewals will primarily be accepted for extended follow up of study participants. The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets are limited to direct costs of 6,250,000 for the entire project period both phases), but need to reflect the actual needs of the proposed project. Direct costs should include capitation dollars to conduct the research. Projects requiring direct costs exceeding 6,250,000 may be proposed, but will require additional NICHD approval as part of the pre-application process.
Project period
The maximum project period for the UG3/UH3 award is 7 years. The UG3 phase may not exceed 2 years. The UH3 phase may not exceed 5 years.The scope of the proposed project should determine the project period and may be up to seven years. The extended seven-year project period is intended primarily to facilitate follow up of study populations as relevant outcomes may require longer…
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PAR-23-037.

Other open NOFOs for UG3, UH3

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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