NIH PAR · NCCIH · R01

PAR-25-268: Investigator Initiated Clinical Trials of Complementary and Integrative Interventions Delivered Remotely or via mHealth (R01 Clinical Trial Required)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Oct 20, 2026Expires Nov 18, 2026

This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated fully remotely delivered and conducted clinical trials to assess the efficacy or effectiveness of complementary and integrative health interventions in NCCIH- designated areas of high research priority. Applications submitted under this NOFO are expected to propose a remotely delivered and conducted fully powered clinical trial with no in-person contact between research staff and study participants and may utilize mHealth tools or technologies. Applicants must provide justification for the remotely delivered approach and provide preliminary data on the feasibility and safety of the approach, along…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-268
Type
PAR
Activity code
R01
Primary institute
NCCIH · National Center for Complementary and Integrative Health
Clinical trials
Required
Posted
Nov 21, 2024
Opens
Jan 20, 2025
Expires
Nov 18, 2026

PAR-25-268 due dates

1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-268
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
February 20, 2025February 20, 2025March 10, 2025July 2025October 2025December 2025
June 20, 2025June 20, 2025July 15, 2025November 2025January 2026April 2026
October 20, 2025October 20, 2025November 18, 2025March 2026May 2026July 2026
February 20, 2026February 20, 2026March 17, 2026July 2026October 2026December 2026
June 22, 2026June 22, 2026Not ApplicableNovember 2026January 2027April 2027
October 20, 2026October 20, 2026Not ApplicableMarch 2027May 2027July 2027

Projects funded under PAR-25-268

NIH RePORTER lists 6 projects funded under PAR-25-268 in FY2022–FY2026, with $6.1M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

6

Distinct projects, FY2022–FY2026

New awards

6

Type 1 (new project) award records

NIH funding

$6.1M

Award dollars under PAR-25-268, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-268
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY202666$6.1M

Institutions with the most funding

  1. Utah State Higher Education System--University of Utah$2.1M · 1 project
  2. Vanderbilt University Medical Center$891K · 1 project
  3. Cornell University$854K · 1 project
  4. University of Pennsylvania$812K · 1 project
  5. Mayo Clinic Jacksonville$780K · 1 project
  6. Drexel University$677K · 1 project

Funding institutes

  • NCCIH$6.1M · 6

Activity codes funded

Most recent new awards

What its predecessor PAR-24-083 funded

PAR-25-268 reissues PAR-24-083. Its funding history is the best guide to who wins under this program: 1 project and $601K in FY2022–FY2026.

Projects funded

1

Distinct projects, FY2022–FY2026

New awards

1

Type 1 (new project) award records

NIH funding

$601K

Award dollars under PAR-24-083, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-24-083
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY202611$601K

Institutions with the most funding

  1. University of California, San Francisco$601K · 1 project

Funding institutes

  • NCCIH$601K · 1

Activity codes funded

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under PAR-25-268. Contact the program officer at the institute that fits your research before applying.

  • NCCIH · National Center for Complementary and Integrative Health
  • none

Related notices

  1. Sep 9, 2025 · NOT-AT-25-008

    Notice of Correction to Key Date(s) for PAR-25-268 Investigator Initiated Clinical Trials of Complementary and Integrative Interventions Delivered Remotely or via mHealth R01 Clinical Trial Required)".

  2. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  3. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  4. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Notices of Special Interest (NOSIs)

NIH has attached 4 NOSIs to PAR-25-268; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.

Award terms

Application types allowed
NewRenewalResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets are not limited but need to reflect the actual needs of the proposed project.
Project period
The scope of the proposed project should determine the project period. The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
 The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

Other open NOFOs for R01

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About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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