NIH RFA · NINDS · R01
RFA-NS-28-010: BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R01 Clinical Trial Not Allowed)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
This funding opportunity supports transformative, mechanistic research aimed at understanding how the human brain functions. Applications should seek to reveal how the dynamic activity of individual neurons and ensembles of neurons within spatially organized brain networks gives rise to internal experiences, such as sensations, perceptions, emotions, thoughts, and memories, as well as to observable motor and social behaviors. To achieve fundamental mechanistic insights into human brain function, proposed studies are expected to leverage opportunities made possible by invasive surgical procedures in humans, such as intracranial recording or stimulation. These investigations may be enhanced…
- NOFO number
- RFA-NS-28-010
- Type
- RFA
- Activity code
- R01
- Primary institute
- NINDS · National Institute of Neurological Disorders and Stroke
- Clinical trials
- Not Allowed
- Posted
- Sep 30, 2026
- Opens
- Jan 8, 2027
- Expires
- Feb 9, 2029
RFA-NS-28-010 due dates
3 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| February 08, 2027 | February 08, 2027 | Not Applicable | July 2027 | October 2027 | December 2027 |
| February 08, 2028 | February 08, 2028 | Not Applicable | July 2028 | October 2028 | December 2028 |
| February 08, 2029 | February 08, 2029 | Not Applicable | July 2029 | October 2029 | December 2029 |
What its predecessor RFA-NS-22-041 funded
RFA-NS-28-010 reissues RFA-NS-22-041. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 2 projects and $6.0M in FY2022–FY2026.
Projects funded
2
Distinct projects, FY2022–FY2026
New awards
2
Type 1 (new project) award records
NIH funding
$6.0M
Award dollars under RFA-NS-22-041, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 1 | 1 | $1.0M |
| FY2024 | 2 | 1 | $2.1M |
| FY2025 | 1 | 0 | $890K |
| FY2026 | 2 | 0 | $1.9M |
Institutions with the most funding
- UT Southwestern Medical Center$3.7M · 1 project
- University of Iowa$2.3M · 1 project
Funding institutes
- NINDS$6.0M · 6
Activity codes funded
- U016 records
Most recent new awards
- Laminar Circuit Motifs for Working Memory and Language Combinatorics: From Cells to Systems (opens NIH RePORTER)
University of Iowa · 1U01NS137991-01 · NINDS · Notice Sep 17, 2024
$1.2MU01
- Modeling and Mapping Human Action Regulation Networks (opens NIH RePORTER)
UT Southwestern Medical Center · 1U01NS132788-01 · NINDS · Notice Aug 21, 2023
$1.0MU01
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
10 NIH institutes and offices take applications under RFA-NS-28-010. Contact the program officer at the institute that fits your research before applying.
- NINDS · National Institute of Neurological Disorders and Stroke
- NEI · National Eye Institute
- NIA · National Institute on Aging
- NIAAA · National Institute on Alcohol Abuse and Alcoholism
- NIBIB · National Institute of Biomedical Imaging and Bioengineering
- NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NIDCD · National Institute on Deafness and Other Communication Disorders
- NIDA · National Institute on Drug Abuse
- NIMH · National Institute of Mental Health
- NCCIH · National Center for Complementary and Integrative Health
Related notices
NIH lists no related notices for RFA-NS-28-010 yet.
Award terms
- Application types allowed
- New Renewal Resubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets need to reflect the actual needs of the proposed project. It is anticipated that most awards will not exceed 1M direct costs.
- Project period
- The scope of the proposed project should determine the project period. The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- Issuing IC and partner components intend to commit an estimated total of up to 8M to fund 5 awards per receipt date.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of RFA-NS-22-041.
Other open NOFOs for R01
- PAR-25-077CCRP Initiative: NIH Countermeasures Against Chemical Threats (CounterACT) Basic Research on Chemical Threats that Affect the Nervous System (R01 Clinical Trial Not Allowed)NINDS · next due Oct 16, 2026
- PAR-25-371Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)NHGRI · next due Oct 20, 2026
- PAR-27-090Palliative Care Research Across the Lifespan: Leveraging the Palliative Care Consortium (R01 Clinical Trial Optional)NIA · next due Feb 5, 2027
- PA-25-301NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)NIH · next due Feb 5, 2027
- PA-25-305NIH Research Project Grant (Parent R01 Clinical Trial Required)NIH · next due Feb 5, 2027
- PAR-24-330Interventions to Reduce Sleep Health Disparities (R01 - Clinical Trials Optional)NIMHD · next due Feb 5, 2027
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.