NIH PAR · NHGRI · R01
PAR-25-255: Developing novel theory and methods for understanding the genetic architecture of complex human traits (R01 Clinical Trial Not Allowed)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The goal of this NOFO is to support applications for novel theory and methods development that enable better understanding of how genetic and non-genetic factors contribute to complex trait variation across individuals, families, and populations. Approaches should be interdisciplinary drawing from the natural and social sciences, account for interdependencies across scales of biological, social, and ecological organization, and make extensive use of theory, modeling, and validation with available large-scale datasets.
- NOFO number
- PAR-25-255
- Type
- PAR
- Activity code
- R01
- Primary institute
- NHGRI · National Human Genome Research Institute
- Clinical trials
- Not Allowed
- Posted
- Nov 15, 2024
- Opens
- Jan 5, 2025
- Expires
- Nov 6, 2026
PAR-25-255 due dates
No application due dates remain in the listed cycles. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Application Due Date(s) | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| February 05, 2025 | March 05, 2025 * | Not Applicable | July 2025 | October 2025 | December 2025 |
| June 05, 2025 | July 05, 2025 * | Not Applicable | November 2025 | January 2026 | April 2026 |
| October 05, 2025 | November 05, 2025 * | Not Applicable | March 2026 | May 2026 | July 2026 |
| February 05, 2026 | March 05, 2026 * | Not Applicable | July 2026 | October 2026 | December 2026 |
| June 05, 2026 | July 05, 2026 * | Not Applicable | November 2026 | January 2027 | April 2027 |
| October 05, 2026 | November 05, 2026 * | Not Applicable | March 2027 | May 2027 | July 2027 |
Projects funded under PAR-25-255
NIH RePORTER lists 1 project funded under PAR-25-255 in FY2022–FY2026, with $763K in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.
Projects funded
1
Distinct projects, FY2022–FY2026
New awards
1
Type 1 (new project) award records
NIH funding
$763K
Award dollars under PAR-25-255, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 0 | 0 | $0 |
| FY2026 | 1 | 1 | $763K |
Institutions with the most funding
- University of Texas at Austin$763K · 1 project
Funding institutes
- NHGRI$763K · 1
Activity codes funded
- R011 record
Most recent new awards
- Expanding Genomic SEM for Applications to Highly Multivariate Data (opens NIH RePORTER)
University of Texas at Austin · 1R01HG014691-01A1 · NHGRI · Notice Sep 7, 2026
$763KR01
What its predecessor PAR-23-302 funded
PAR-25-255 reissues PAR-23-302. Its funding history is the best guide to who wins under this program: 2 projects and $4.0M in FY2022–FY2026.
Projects funded
2
Distinct projects, FY2022–FY2026
New awards
2
Type 1 (new project) award records
NIH funding
$4.0M
Award dollars under PAR-23-302, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 1 | 1 | $780K |
| FY2026 | 2 | 1 | $3.2M |
Institutions with the most funding
- University of California Los Angeles$3.1M · 1 project
- Harvard Medical School$839K · 1 project
Funding institutes
- NCI$3.1M · 2
- NHGRI$839K · 1
Activity codes funded
- R013 records
Most recent new awards
- Leveraging ancient DNA to elucidate the genetic architecture of complex human traits (opens NIH RePORTER)
Harvard Medical School · 1R01HG013987-01A1 · NHGRI · Notice May 5, 2026
$839KR01
- Simulation, modelling, and estimation of direct and indirect genetic architectures and intergenerational dynamics (opens NIH RePORTER)
University of California Los Angeles · 1R01CA313942-01 · NCI · Notice Aug 29, 2025
$780KR01
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
3 NIH institutes and offices take applications under PAR-25-255. Contact the program officer at the institute that fits your research before applying.
- NHGRI · National Human Genome Research Institute
- NIMH · National Institute of Mental Health
- NCI · National Cancer Institute
Related notices
Mar 31, 2025 · NOT-OD-24-084
This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Award terms
- Application types allowed
- NewRenewalResubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets are not limited but need to reflect the actual needs of the proposed project. nbsp;For NCI applications, the budget is limited to 350,000 direct costs per year and should reflect the actual needs of the proposed project.
- Project period
- The scope of the proposed project should determine the project period. The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAR-23-302.
- Companion NOFOs: PAR-25-256.
Other open NOFOs for R01
- PAR-25-371Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)NHGRI · next due Oct 20, 2026
- RFA-HG-25-009Supporting Talented Early Career Researchers in Genomics (R01 Clinical Trial Optional)NHGRI · next due Feb 26, 2027
- PAR-25-322Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed)OD · next due Jan 26, 2027
- PA-25-301NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)NIH · next due Feb 5, 2027
- PA-25-305NIH Research Project Grant (Parent R01 Clinical Trial Required)NIH · next due Feb 5, 2027
- PAR-25-144Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)NCI · next due Feb 5, 2027
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.