NIH PAR · NINDS · UG3, UH3

PAR-25-052: NIH StrokeNet Clinical Trials and Biomarker Studies for Stroke Treatment, Recovery, and Prevention (UG3/UH3 Clinical Trial Optional)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Oct 19, 2026Expires Nov 20, 2026

This NOFO encourages applications for multi-site exploratory and confirmatory clinical trials focused on promising interventions; biomarker or outcome measure validation studies that are immediately preparatory to trials in stroke prevention, treatment, and recovery; and ancillary studies designed to add scientific aims to active studies being conducted within StrokeNet. Successful applicants will collaborate and conduct the study within the NIH StrokeNet. Following peer review, NINDS will prioritize studies among the highest scoring to be conducted in the NIH StrokeNet infrastructure. The NIH StrokeNet National Coordinating Center (NCC) will work with the successful applicant to implement…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-052
Type
PAR
Activity code
UG3UH3
Primary institute
NINDS · National Institute of Neurological Disorders and Stroke
Clinical trials
Optional
Posted
Nov 20, 2024
Opens
Jan 18, 2025
Expires
Nov 20, 2026

PAR-25-052 due dates

1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-052
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
February 19, 2025March 19, 2025Not ApplicableJuly 2025October 2025December 2025
June 20, 2025July 18, 2025Not ApplicableNovember 2025January 2026April 2026
October 20, 2025November 19, 2025Not ApplicableMarch 2026May 2026July 2026
February 19, 2026March 16, 2026Not ApplicableJuly 2026October 2026December 2026
June 18, 2026July 20, 2026Not ApplicableNovember 2026January 2027April 2027
October 19, 2026November 19, 2026Not ApplicableMarch 2027May 2027July 2027

Projects funded under PAR-25-052

NIH RePORTER lists 1 project funded under PAR-25-052 in FY2022–FY2026, with $2.6M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

1

Distinct projects, FY2022–FY2026

New awards

1

Type 1 (new project) award records

NIH funding

$2.6M

Award dollars under PAR-25-052, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-052
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY202611$2.6M

Institutions with the most funding

  1. Cedars-Sinai Medical Center$2.6M · 1 project

Funding institutes

  • NINDS$2.6M · 1

Activity codes funded

  • UG31 record

Most recent new awards

What its predecessor PAR-24-101 funded

PAR-25-052 reissues PAR-24-101. Its funding history is the best guide to who wins under this program: 3 projects and $11.7M in FY2022–FY2026.

Projects funded

3

Distinct projects, FY2022–FY2026

New awards

2

Type 1 (new project) award records

NIH funding

$11.7M

Award dollars under PAR-24-101, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-24-101
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202522$8.1M
FY202610$3.7M

Institutions with the most funding

  1. Stanford University$5.7M · 1 project
  2. Weill Medical Coll of Cornell Univ$3.7M · 1 project
  3. Icahn School of Medicine at Mount Sinai$2.3M · 1 project

Funding institutes

  • NINDS$11.7M · 3

Activity codes funded

  • UG32 records
  • UH31 record

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under PAR-25-052. Contact the program officer at the institute that fits your research before applying.

  • NINDS · National Institute of Neurological Disorders and Stroke
  • none

Related notices

  1. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  2. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  3. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy.

Award terms

Application types allowed
NewResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets are not limited but need to reflect the actual needs of the proposed project.
Project period
The scope of the proposed project should determine the requested project award period. The project period for the UG3 phase will be up to 1 year. The project period for the UH3 phase is expected to be 4 years. With strong justification, up to 6 years for the UH3 may be requested.  NIH grants policies as described in the NIH Grants Policy Statement will apply to the…
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PAR-24-101.

Other open NOFOs for UG3, UH3

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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