NIH RFA · NINDS · RM1
RFA-NS-27-002: BRAIN Initiative: Integrative Team-Research BRAIN Circuits Program - iBCP (RM1 Clinical Trial Not Allowed)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
This Notice of Funding Opportunity (NOFO) supports transdisciplinary research teams seeking to develop mechanistic, biologically grounded explanations of how neural circuits and their cellular building blocks give rise to central nervous system (CNS) function. Teams must integrate expertise spanning molecular and cellular through systems neuroscience, with strong collaboration between experimental and computational investigators, to bridge cells, circuits, and behavior in a unified framework that yields mechanistic insight.Applications must explicitly connect three core elements: (1) characterization of circuit components (e.g., cell types and/or connectivity); (2) measurement of dynamic…
- NOFO number
- RFA-NS-27-002
- Type
- RFA
- Activity code
- RM1
- Primary institute
- NINDS · National Institute of Neurological Disorders and Stroke
- Clinical trials
- Not Allowed
- Posted
- Aug 31, 2026
- Opens
- Sep 7, 2026
- Expires
- Jun 24, 2028
RFA-NS-27-002 due dates
2 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| October 07, 2026 | Not Applicable | Not Applicable | March 2027 | May 2027 | July 2027 |
| June 23, 2027 | Not Applicable | Not Applicable | November 2027 | January 2028 | April 2028 |
| June 23, 2028 | Not Applicable | Not Applicable | November 2028 | January 2029 | April 2029 |
What its predecessor RFA-NS-22-028 funded
RFA-NS-27-002 reissues RFA-NS-22-028. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 4 projects and $19.0M in FY2022–FY2026.
Projects funded
4
Distinct projects, FY2022–FY2026
New awards
4
Type 1 (new project) award records
NIH funding
$19.0M
Award dollars under RFA-NS-22-028, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 4 | 4 | $7.6M |
| FY2024 | 4 | 0 | $5.8M |
| FY2025 | 5 | 0 | $5.7M |
| FY2026 | 0 | 0 | $0 |
Institutions with the most funding
- Salk Institute for Biological Studies$6.0M · 1 project
- Cornell University$5.8M · 1 project
- University of Washington$3.1M · 1 project
- Northwestern University$2.9M · 1 project
- Northwestern University$1.3M · 1 project
Funding institutes
- NINDS$19.0M · 13
Activity codes funded
- U0113 records
Most recent new awards
- Traveling waves in neocortical circuits: Mechanisms, computational roles in sensory processing, and impact on sensory perception (opens NIH RePORTER)
Salk Institute for Biological Studies · 1U01NS131914-01 · NINDS · Notice Aug 31, 2023
$2.5MU01
- Dynamic entanglements: the functional role and mechanistic basis of inter-individual neural synchrony (opens NIH RePORTER)
Northwestern University · 1U01NS131406-01 · NINDS · Notice Jun 14, 2023
$1.4MU01
- Cross-modal sensory interactions, processing, and representation in the Drosophila brain (opens NIH RePORTER)
Cornell University · 1U01NS131438-01 · NINDS · Notice May 12, 2023
$2.5MU01
- Integrative circuit dissection in the behaving nonhuman primate (opens NIH RePORTER)
University of Washington · 1U01NS131810-01 · NINDS · Notice Apr 10, 2023
$1.2MU01
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
11 NIH institutes and offices take applications under RFA-NS-27-002. Contact the program officer at the institute that fits your research before applying.
- NINDS · National Institute of Neurological Disorders and Stroke
- NEI · National Eye Institute
- NIA · National Institute on Aging
- NIAAA · National Institute on Alcohol Abuse and Alcoholism
- NIBIB · National Institute of Biomedical Imaging and Bioengineering
- NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NIDCD · National Institute on Deafness and Other Communication Disorders
- NIDA · National Institute on Drug Abuse
- NIMH · National Institute of Mental Health
- NCCIH · National Center for Complementary and Integrative Health
- OBSSR
Related notices
NIH lists no related notices for RFA-NS-27-002 yet.
Award terms
- Application types allowed
- New The OER Glossary and the How to Apply - Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets need to reflect the actual needs of the proposed project. It is anticipated that most awards will not exceed 1M direct costs per fiscal year.
- Project period
- The scope of the proposed project should determine the project period. The maximum project period is 5 years NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- NIH BRAIN Initiative intends to commit up to 8M per fiscal year to fund up to 5 awards.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of RFA-NS-22-028.
Other open NOFOs for RM1
- PAR-27-003Collaborative Program Grant for Interdisciplinary Teams (RM1 Clinical Trial Optional)NIGMS · next due Nov 17, 2026
- RFA-DA-28-011HEAL Initiative: Integrative Management of Chronic Pain and OUD for Whole Recovery (IMPOWR): Research Centers (RM1 Clinical Trial Required)NIDA · next due Jan 26, 2027
- PAR-27-024Biomedical Technology Optimization and Dissemination Center (BTOD) (RM1 - Clinical Trial Not Allowed)NIGMS · next due Jan 28, 2027
- RFA-DA-25-060High Priority HIV and Substance Use Research (RM1 Clinical Trial Optional)NIDA
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.