NIH RFA · NIDA · RM1

RFA-DA-25-060: High Priority HIV and Substance Use Research (RM1 Clinical Trial Optional)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsExpires Mar 6, 2027

The purpose of this Funding Opportunity Announcement (FOA) is to support high priority research at the intersection of HIV and substance use. This FOA invites innovative research projects with the potential to open new areas of HIV/AIDS research and/or lead to new avenues for prevention, treatment and cure of HIV among people who use drugs (PWUD). Applications submitted under this FOA are required to have a detailed research plan, preliminary data, and a clear description of the nexus with substance use. This FOA is open to both individual researchers and research teams and includes all areas of research from basic science to clinical and implementation research. All studies must focus on…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
RFA-DA-25-060
Type
RFA
Activity code
RM1
Primary institute
NIDA · National Institute on Drug Abuse
Clinical trials
Optional
Posted
Jan 17, 2024
Opens
Jul 15, 2024
Expires
Mar 6, 2027

Projects funded under RFA-DA-25-060

NIH RePORTER lists 6 projects funded under RFA-DA-25-060 in FY2022–FY2026, with $17.9M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

6

Distinct projects, FY2022–FY2026

New awards

6

Type 1 (new project) award records

NIH funding

$17.9M

Award dollars under RFA-DA-25-060, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under RFA-DA-25-060
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202522$4.3M
FY202664$13.6M

Institutions with the most funding

  1. University of California, San Francisco$4.7M · 1 project
  2. Northern California Institute/Res/Edu$4.2M · 1 project
  3. University of California, San Diego$2.5M · 1 project
  4. Yale University$2.2M · 1 project
  5. Father Flanagan's Boys' Home$2.2M · 1 project
  6. Boston Medical Center$2.1M · 1 project

Funding institutes

  • NIDA$17.9M · 8

Activity codes funded

  • RM18 records

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under RFA-DA-25-060. Contact the program officer at the institute that fits your research before applying.

  • NIDA · National Institute on Drug Abuse
  • none

Related notices

  1. Jan 28, 2026 · NOT-OD-26-029

    NIH Removing AIDS Application Due Dates from NOFOs.

  2. Mar 31, 2025

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.

  3. Apr 4, 2024 · NOT-OD-24-084

    Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025. See Notice NOT-OD-24-084 March 20, 024 - Notice of Pre-Application Technical Assistance Webinar for RFA-DA-25-060.

  4. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  5. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Notices of Special Interest (NOSIs)

NIH has attached 1 NOSI to RFA-DA-25-060; 1 are active. A NOSI flags a topic an institute wants to fund through this NOFO.

Award terms

Application types allowed
NewResubmissionRevision The OER Glossary and the SF424 R&R) Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Individual award budgets are not to exceed 1.5M per Fiscal Year in direct costs and should reflect the actual scope of the proposed project.
Project period
The scope of the proposed project should determine the project period. The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
NIDA intends to commit 3.0 M in FY 2025, 2026, and 2027 to fund one-two awards.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Companion NOFOs: RFA-DA-22-040.

Other open NOFOs for RM1

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

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