NIH RFA · NIDDK · U01

RFA-DK-27-122: Single Source for the Continuation of the Physiology of the Weight Reduced State (POWERS) Study (U01- Clinical Trials Required)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Nov 17, 2026Expires Nov 18, 2026

The purpose of this NOFO is to continue the Physiology of the Weight Reduced State (POWERS) clinical trial. The goal of POWERS is to understand the physiological processes underlying individual variability in weight regain following weight loss due to a lifestyle intervention. The continuation of POWERS will allow for the completion of the ongoing clinical trial and to conduct analysis of collected data and biospecimens. This NOFO invites a single source application from the Data Coordinating Center for the POWERS consortium. Please see Section III. Eligibility for additional information. In accordance with NIH standard peer-review processes, the application will be peer-reviewed, and only…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
RFA-DK-27-122
Type
RFA
Activity code
U01
Primary institute
NIDDK · National Institute of Diabetes and Digestive and Kidney Diseases
Clinical trials
Required
Posted
Oct 15, 2026
Opens
Oct 16, 2026
Expires
Nov 18, 2026

RFA-DK-27-122 due dates

1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for RFA-DK-27-122
NewRenewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
November 17, 2026Not ApplicableNot ApplicableMarch 2027May 2027July 2027

Funded projects

NIH RePORTER lists no awards under RFA-DK-27-122 in FY2022–FY2026, and it is a new NOFO rather than a reissue. Awards usually appear a few months after the first review cycle.

Participating institutes

2 NIH institutes and offices take applications under RFA-DK-27-122. Contact the program officer at the institute that fits your research before applying.

  • NIDDK · National Institute of Diabetes and Digestive and Kidney Diseases
  • none

Related notices

NIH lists no related notices for RFA-DK-27-122 yet.

Award terms

Application types allowed
New The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Direct costs are not limited but need to reflect the actual needs of the proposed project.
Project period
The maximum project period is 3 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
NIDDK intends to commit up to 3.85 M in FY27 and up to 3.25M per year in FY28 and FY29 to fund one award.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

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About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

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