NIH PAR · NCCIH · R01
PAR-25-271: NCCIH Natural Product Mid Phase Clinical Trial (R01 Clinical Trial Required)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
This Notice of Funding Opportunity (NOFO) encourages applications for investigator-initiated mid-phase clinical trials of natural products(i.e., botanicals, dietary supplements, and probiotics), which have a strong scientific premise to justify further clinical testing. For this NOFO, natural products include promising nutritional regimens that standardize the amount of a specific naturally occurring nutritional compound (e.g., omega-3 fatty acids, anthocyanidins, or polyphenols) and have compelling preliminary evidence. All applications submitted under this NOFO must be supported by sufficient preliminary data demonstrating bioavailability (if applicable) and documentation that the natural…
- NOFO number
- PAR-25-271
- Type
- PAR
- Activity code
- R01
- Primary institute
- NCCIH · National Center for Complementary and Integrative Health
- Clinical trials
- Required
- Posted
- Dec 2, 2024
- Opens
- May 23, 2025
- Expires
- Nov 14, 2026
PAR-25-271 due dates
1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Application Due Date(s) | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| June 23, 2025 | June 23, 2025 | July 17, 2025 | November 2025 | January 2026 | April 2026 |
| February 23, 2026 | February 23, 2026 | March 17, 2026 | July 2026 | October 2026 | December 2026 |
| October 20, 2026 | October 20, 2026 | Not Applicable | March 2027 | May 2027 | July 2027 |
What its predecessor PAR-24-115 funded
PAR-25-271 reissues PAR-24-115. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 1 project and $1.2M in FY2022–FY2026.
Projects funded
1
Distinct projects, FY2022–FY2026
New awards
1
Type 1 (new project) award records
NIH funding
$1.2M
Award dollars under PAR-24-115, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 1 | 1 | $631K |
| FY2026 | 1 | 0 | $612K |
Institutions with the most funding
- Sloan-Kettering Inst Can Research$1.2M · 1 project
Funding institutes
- NCCIH$1.2M · 2
Activity codes funded
- R012 records
Most recent new awards
- Isoquercetin as a PDI inhibitor: dose-optimization and patient phenotyping (opens NIH RePORTER)
Sloan-Kettering Inst Can Research · 1R01AT013147-01 · NCCIH · Notice Apr 10, 2025
$631KR01
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
2 NIH institutes and offices take applications under PAR-25-271. Contact the program officer at the institute that fits your research before applying.
- NCCIH · National Center for Complementary and Integrative Health
- none
Related notices
Sep 8, 2025 · NOT-AT-25-010
Notice of Correction to Section IV Application Form Instructions for PAR-25-271 NCCIH Natural Product Mid Phase Clinical Trial R01 Clinical Trial Required)".
Mar 31, 2025 · NOT-OD-24-084
This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Award terms
- Application types allowed
- NewResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets are not limited, but it is strongly recommended that applications not request more than 350,000 per year in direct costs per year. A strong rationale must be provided for budgets that exceed this recommendation. Budgets should reflect the actual needs of the proposed project.
- Project period
- The scope of the proposed project should determine the project period, but it is strongly recommended that applications not request more than three years of funding support. A strong rationale must be provided for project periods that exceed this recommendation. The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the…
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAR-24-115.
- Companion NOFOs: PAR-24-312, PAR-24-313, PAR-25-269.
Other open NOFOs for R01
- PAR-25-267NCCIH Multi-Site Feasibility Clinical Trials of Mind and Body Interventions (R01 Clinical Trial Required)NCCIH · next due Oct 20, 2026
- PAR-25-268Investigator Initiated Clinical Trials of Complementary and Integrative Interventions Delivered Remotely or via mHealth (R01 Clinical Trial Required)NCCIH · next due Oct 20, 2026
- PAR-25-322Stephen I. Katz Early Stage Investigator Research Project Grant (R01 Clinical Trial Not Allowed)OD · next due Jan 26, 2027
- PA-25-301NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)NIH · next due Feb 5, 2027
- PA-25-305NIH Research Project Grant (Parent R01 Clinical Trial Required)NIH · next due Feb 5, 2027
- PAR-25-144Dissemination and Implementation Research in Health (R01 Clinical Trial Optional)NCI · next due Feb 5, 2027
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.