NIH PAR · NIAMS · UG3, UH3

PAR-25-141: NIAMS Clinical Trial Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Nov 2, 2026Expires Mar 5, 2027

This NIAMS Clinical Trial Implementation Cooperative Agreement (UG3/UH3 Clinical Trial Required) PAR, a re-issue of PAR-24-208, was re-issued as a result of the Simplifying Review of Research Project Grant Applications [link: https://grants.nih.gov/policy-and-compliance/policy-topics/peer-review/simplifying-review]. The Simplified Review changes in Section V. Application Review Information of the funding opportunity are the only changes that have been made. All other aspects of this funding opportunity remain the same.

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-141
Type
PAR
Activity code
UG3UH3
Primary institute
NIAMS · National Institute of Arthritis and Musculoskeletal and Skin Diseases
Clinical trials
Required
Posted
Dec 9, 2024
Opens
Feb 4, 2025
Expires
Mar 5, 2027

PAR-25-141 due dates

2 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-141
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
March 04, 2025March 04, 2025Not ApplicableJuly 2025October 2025December 2025
July 02, 2025July 02, 2025Not ApplicableNovember 2025January 2026April 2026
November 04, 2025November 04, 2025Not ApplicableMarch 2026May 2026July 2026
March 04, 2026March 04, 2026Not ApplicableJuly 2026October 2026December 2026
July 02, 2026July 02, 2026Not ApplicableNovember 2026January 2027April 2027
November 02, 2026November 02, 2026Not ApplicableMarch 2027May 2027July 2027
March 04, 2027March 04, 2027Not ApplicableJuly 2027October 2027December 2027

Projects funded under PAR-25-141

NIH RePORTER lists 5 projects funded under PAR-25-141 in FY2022–FY2026, with $1.9M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

5

Distinct projects, FY2022–FY2026

New awards

5

Type 1 (new project) award records

NIH funding

$1.9M

Award dollars under PAR-25-141, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-141
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY202655$1.9M

Institutions with the most funding

  1. Children's Hosp of Philadelphia$454K · 1 project
  2. Stanford University$446K · 1 project
  3. University of Connecticut Storrs$420K · 1 project
  4. Utah State Higher Education System--University of Utah$344K · 1 project
  5. Washington University$213K · 1 project

Funding institutes

  • NIAMS$1.9M · 5

Activity codes funded

  • UG35 records

Most recent new awards

What its predecessor PAR-24-208 funded

PAR-25-141 reissues PAR-24-208. Its funding history is the best guide to who wins under this program: 4 projects and $3.8M in FY2022–FY2026.

Projects funded

4

Distinct projects, FY2022–FY2026

New awards

2

Type 1 (new project) award records

NIH funding

$3.8M

Award dollars under PAR-24-208, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-24-208
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202522$601K
FY202620$3.2M

Institutions with the most funding

  1. Henry Ford Health + Michigan State University Health Sciences$2.4M · 2 projects
  2. Johns Hopkins University$1.4M · 2 projects

Funding institutes

  • NIAMS$3.8M · 4

Activity codes funded

  • UG32 records
  • UH32 records

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under PAR-25-141. Contact the program officer at the institute that fits your research before applying.

  • NIAMS · National Institute of Arthritis and Musculoskeletal and Skin Diseases
  • none

Related notices

  1. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  2. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  3. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Notices of Special Interest (NOSIs)

NIH has attached 2 NOSIs to PAR-25-141; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.

Award terms

Application types allowed
NewResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Applications budgets are limited to 250,000 direct costs for the UG3 phase, but are not limited for the UH3 phase. However, budgets need to reflect the actual needs of the proposed project.
Project period
The scope of the proposed project should determine the project period. The project period is limited to six years: up to one year for the first phase UG3) and up to five years for the second phase UH3).   NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. 

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PAR-24-208.

Other open NOFOs for UG3, UH3

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

NIH grant searchLook up awards by topic, PI, or institution.Find funded PIsInvestigators with recent NIH awards in your research area.Institute fit by topicWhich NIH institutes and institutions lead a research area.Funding trendsYear-by-year NIH award totals for any keyword.