NIH PAR · NIDCR · R03
PAR-25-105: NIDCR Small Grant Program for New Investigators (R03 Clinical Trial Not Allowed)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
This NIDCR Small Grant Program for New Investigators supports basic and clinical research conducted by scientists who are in the early stages of establishing an independent research career in oral, dental and craniofacial research. This R03 program supports pilot or feasibility studies and developmental research projects with the intention of obtaining sufficient preliminary data for a subsequent investigator initiated Research Project Grant (R01) or equivalent application.
- NOFO number
- PAR-25-105
- Type
- PAR
- Activity code
- R03
- Primary institute
- NIDCR · National Institute of Dental and Craniofacial Research
- Clinical trials
- Not Allowed
- Posted
- Nov 18, 2024
- Opens
- Jan 16, 2025
- Expires
- Jan 8, 2028
PAR-25-105 due dates
4 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Application Due Date(s) | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| February 16, 2025 | March 16, 2025 * | May 07, 2025 * | July 2025 | October 2025 | December 2025 |
| June 16, 2025 | July 16, 2025 * | September 07, 2025 * | November 2025 | January 2026 | April 2026 |
| October 16, 2025 | November 16, 2025 * | January 07, 2026 * | March 2026 | May 2026 | July 2026 |
| February 16, 2026 | March 16, 2026 * | May 07, 2026 * | July 2026 | October 2026 | December 2026 |
| June 16, 2026 | July 16, 2026 * | Not Applicable | November 2026 | January 2027 | April 2027 |
| October 16, 2026 | November 16, 2026 * | Not Applicable | March 2027 | May 2027 | July 2027 |
| February 16, 2027 | March 16, 2027 * | Not Applicable | July 2027 | October 2027 | December 2027 |
| June 16, 2027 | July 16, 2027 * | Not Applicable | November 2027 | January 2028 | April 2028 |
| October 16, 2027 | November 16, 2027 * | Not Applicable | March 2028 | May 2028 | July 2028 |
Projects funded under PAR-25-105
NIH RePORTER lists 24 projects funded under PAR-25-105 in FY2022–FY2026, with $7.5M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.
Projects funded
24
Distinct projects, FY2022–FY2026
New awards
24
Type 1 (new project) award records
NIH funding
$7.5M
Award dollars under PAR-25-105, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 0 | 0 | $0 |
| FY2026 | 24 | 24 | $7.5M |
Institutions with the most funding
- University of Illinois at Chicago$641K · 2 projects
- State University of New York at Buffalo$640K · 2 projects
- Indiana University Indianapolis$634K · 2 projects
- Touro University of California$362K · 1 project
- Oklahoma Medical Research Foundation$341K · 1 project
- Columbia University Health Sciences$329K · 1 project
- University of California, San Francisco$328K · 1 project
- University of California Los Angeles$315K · 1 project
Funding institutes
- NIDCR$7.5M · 24
Activity codes funded
- R0324 records
Most recent new awards
- Mechanistic insights into cisplatin resistance during secondhand smoke exposure (opens NIH RePORTER)
University of Oklahoma Hlth Sciences Ctr · 1R03DE036378-01 · NIDCR · Notice Sep 17, 2026
$286KR03
- Orofacial Biomechanics and the Consequences of Alveolar Cleft Morphology: Clinical Translation for Comprehensive Craniofacial Care (opens NIH RePORTER)
Touro University of California · 1R03DE036042-01 · NIDCR · Notice Sep 17, 2026
$362KR03
- Defining the Oral-Gut–Bone Axis: GLP Signaling Links Periodontitis to Bone Loss (opens NIH RePORTER)
Indiana University Indianapolis · 1R03DE036471-01 · NIDCR · Notice Sep 8, 2026
$317KR03
- Type-2 Cytokine Regulation of Tuft Cell Differentiation in Salivary Glands (opens NIH RePORTER)
State University of New York at Buffalo · 1R03DE036291-01 · NIDCR · Notice Sep 1, 2026
$320KR03
- Engineering the degradation of decellularized plant scaffolds for hard tissue engineering (opens NIH RePORTER)
Boston College · 1R03DE036044-01 · NIDCR · Notice Sep 1, 2026
$310KR03
- Bridging the Gap in Pediatric TMD and Migraine Through Multidimensional Phenotyping and Precision Pain Profiling (opens NIH RePORTER)
Univ of North Carolina Chapel Hill · 1R03DE036051-01 · NIDCR · Notice Aug 31, 2026
$310KR03
What its predecessor PAR-21-084 funded
PAR-25-105 reissues PAR-21-084. Its funding history is the best guide to who wins under this program: 80 projects and $24.1M in FY2022–FY2026.
Projects funded
80
Distinct projects, FY2022–FY2026
New awards
79
Type 1 (new project) award records
NIH funding
$24.1M
Award dollars under PAR-21-084, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 20 | 18 | $3.0M |
| FY2023 | 34 | 14 | $6.0M |
| FY2024 | 24 | 17 | $4.6M |
| FY2025 | 40 | 30 | $9.5M |
| FY2026 | 7 | 0 | $879K |
Institutions with the most funding
- Ohio State University$1.6M · 5 projects
- State University of New York at Buffalo$1.5M · 5 projects
- Virginia Commonwealth University$930K · 3 projects
- University of Minnesota$920K · 3 projects
- University of Florida$919K · 3 projects
- University of Louisville$782K · 2 projects
- University of California, San Francisco$652K · 2 projects
- Temple Univ of the Commonwealth$647K · 2 projects
Funding institutes
- NIDCR$24.1M · 125
Activity codes funded
- R03125 records
Most recent new awards
- Identifying Subgroups of Adolescents with Chronic Temporomandibular Disorder Pain to Guide Personalized Treatment (opens NIH RePORTER)
Univ of North Carolina Chapel Hill · 1R03DE034768-01 · NIDCR · Notice Sep 11, 2025
$310KR03
- Targeting TRPC1: A Novel Approach to Treat Oral Cancer (opens NIH RePORTER)
University of Texas Hlth Science Center · 1R03DE034049-01A1 · NIDCR · Notice Aug 20, 2025
$315KR03
- Identification of candidate genomic regulatory elements involved in oral clefts (opens NIH RePORTER)
Marshfield Clinic, Inc. · 1R03DE034666-01 · NIDCR · Notice Aug 13, 2025
$1R03
- Chemoprevention of Electronic Cigarette Promoted Oral Squamous Cell Carcinoma (opens NIH RePORTER)
State University New York Stony Brook · 1R03DE034788-01 · NIDCR · Notice Aug 7, 2025
$317KR03
- Role of Macrophage Migration Inhibitory Factor (MIF) in KSHV-associated Malignancies (opens NIH RePORTER)
Univ of Arkansas for Med Scis · 1R03DE034653-01A1 · NIDCR · Notice Jul 23, 2025
$306KR03
- Characterizing the microbial and inflammatory state within distant clinically healthy tissues in patients with active periodontal disease (opens NIH RePORTER)
University of Washington · 1R03DE034443-01A1 · NIDCR · Notice Jul 18, 2025
$311KR03
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
2 NIH institutes and offices take applications under PAR-25-105. Contact the program officer at the institute that fits your research before applying.
- NIDCR · National Institute of Dental and Craniofacial Research
- none
Related notices
Jan 28, 2026 · NOT-OD-26-029
NIH Removing AIDS Application Due Dates from NOFOs. See Notice NOT-OD-26-029.
Mar 31, 2025 · NOT-OD-24-084
This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Notices of Special Interest (NOSIs)
NIH has attached 4 NOSIs to PAR-25-105; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.
Award terms
- Application types allowed
- NewResubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- A budget for direct costs of up to 200,000 may be requested. Application budgets are limited to 100,000 in direct costs per year.
- Project period
- The total project period may not exceed two years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAR-21-084.
Other open NOFOs for R03
- PAR-25-370Ethical, Legal and Social Implications (ELSI) Small Research Grant (R03 Clinical Trial Optional)NHGRI · next due Oct 16, 2026
- PAR-25-233Dissemination and Implementation Research in Health (R03 Clinical Trial Not Allowed)NCI · next due Oct 16, 2026
- PAR-25-122Pilot Projects Investigating Understudied Proteins Associated with Rare Diseases (R03 Clinical Trial Not Allowed)NCATS · next due Oct 16, 2026
- RFA-RM-27-024Pilot Projects to Enhance the Human Virome Program (R03 Clinical Trials Not Allowed)RMOD · next due Nov 10, 2026
- PAR-27-096Grants for Early Medical/Surgical Specialists' Transition to Aging Research (GEMSSTAR) (R03 Clinical Trial Optional)NIA · next due Nov 10, 2026
- PAS-27-028Science Track Award for Research Transition (START) Program (R03, Clinical Trial Optional)NIDA · next due Oct 16, 2026
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.