NIH PAR · NINDS · R01
PAR-25-077: CCRP Initiative: NIH Countermeasures Against Chemical Threats (CounterACT) Basic Research on Chemical Threats that Affect the Nervous System (R01 Clinical Trial Not Allowed)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
This announcement invites applications for basic research projects on chemical warfare agents, toxic industrial chemicals, and pesticides that have primary or secondary effects on the nervous system. Chemical threats are toxic compounds that could be used in a terrorist attack or accidentally released from industrial production, storage, or shipping. Projects supported by this NOFO are expected to generate data that elucidate mechanisms of toxicity of these agents, possible new manifestations of toxic exposures, and potential new targets for therapeutic development.
- NOFO number
- PAR-25-077
- Type
- PAR
- Activity code
- R01
- Primary institute
- NINDS · National Institute of Neurological Disorders and Stroke
- Clinical trials
- Not Allowed
- Posted
- Nov 1, 2024
- Opens
- Sep 17, 2025
- Expires
- Oct 17, 2026
PAR-25-077 due dates
1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Application Due Date(s) | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| October 17, 2025 | October 17, 2025 | Not Applicable | March 2026 | May 2026 | July 2026 |
| October 16, 2026 | October 16, 2026 | Not Applicable | March 2027 | May 2027 | July 2027 |
Projects funded under PAR-25-077
NIH RePORTER lists 4 projects funded under PAR-25-077 in FY2022–FY2026, with $1.8M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.
Projects funded
4
Distinct projects, FY2022–FY2026
New awards
4
Type 1 (new project) award records
NIH funding
$1.8M
Award dollars under PAR-25-077, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 0 | 0 | $0 |
| FY2026 | 4 | 4 | $1.8M |
Institutions with the most funding
- University of California, San Diego$477K · 1 project
- Rutgers Biomedical and Health Sciences$471K · 1 project
- University of California at Davis$469K · 1 project
- University of Tennessee Health Sci Ctr$404K · 1 project
Funding institutes
- NINDS$1.8M · 4
Activity codes funded
- R013 records
- R561 record
Most recent new awards
- Neuronal subcellular mechanisms in susceptibility and resilience to toxic chemicals of concern (opens NIH RePORTER)
University of California, San Diego · 1R56NS144209-01A1 · NINDS · Notice Sep 17, 2026
$477KR56
- JAK/STAT signaling as a therapeutic target to mitigate long-term effects of acute organophosphate intoxication (opens NIH RePORTER)
University of California at Davis · 1R01NS151264-01 · NINDS · Notice Aug 20, 2026
$469KR01
- Astrocyte-based mechanisms of organophosphate poisoning (opens NIH RePORTER)
Rutgers Biomedical and Health Sciences · 1R01NS144283-01A1 · NINDS · Notice Aug 17, 2026
$471KR01
- Mechanistic and Therapeutic Strategies to Mitigate Arsenic Trioxide-Induced Neurotoxicity (opens NIH RePORTER)
University of Tennessee Health Sci Ctr · 1R01NS152092-01 · NINDS · Notice Aug 14, 2026
$404KR01
What its predecessor PAR-24-030 funded
PAR-25-077 reissues PAR-24-030. Its funding history is the best guide to who wins under this program: 2 projects and $1.4M in FY2022–FY2026.
Projects funded
2
Distinct projects, FY2022–FY2026
New awards
2
Type 1 (new project) award records
NIH funding
$1.4M
Award dollars under PAR-24-030, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 2 | 2 | $922K |
| FY2026 | 1 | 0 | $462K |
Institutions with the most funding
- University of California at Davis$887K · 1 project
- Beth Israel Deaconess Medical Center$497K · 1 project
Funding institutes
- NINDS$1.4M · 3
Activity codes funded
- R012 records
- R561 record
Most recent new awards
- Impaired Sleep as a Target for Intervention Following Acute Organophosphate Intoxication (opens NIH RePORTER)
University of California at Davis · 1R01NS144287-01 · NINDS · Notice Jul 24, 2025
$425KR01
- Mechanisms of Cyanide-Induced Neurotoxicity and Purine Dysregulation (opens NIH RePORTER)
Beth Israel Deaconess Medical Center · 1R56NS144203-01 · NINDS · Notice Jul 23, 2025
$497KR56
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
2 NIH institutes and offices take applications under PAR-25-077. Contact the program officer at the institute that fits your research before applying.
- NINDS · National Institute of Neurological Disorders and Stroke
- NIAID · National Institute of Allergy and Infectious Diseases
Related notices
Mar 31, 2025 · NOT-OD-24-084
This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022
Implementation Details for the NIH Data Management and Sharing Policy.
Award terms
- Application types allowed
- NewResubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets may not exceed 300,000 in direct costs per year.Many applications will not need to request the maximum budget and the requested budget will need to reflect the actual needs of the proposed project.
- Project period
- The maximum project period is 3 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- NIH intends to support up to 4 awards, corresponding to a total of 2 M in FY 2026. Future year amounts will depend on annual appropriations.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAR-24-030.
Other open NOFOs for R01
- RFA-NS-28-010BRAIN Initiative: Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R01 Clinical Trial Not Allowed)NINDS · next due Feb 8, 2027
- PAR-25-371Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)NHGRI · next due Oct 20, 2026
- PAR-27-090Palliative Care Research Across the Lifespan: Leveraging the Palliative Care Consortium (R01 Clinical Trial Optional)NIA · next due Feb 5, 2027
- PA-25-301NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)NIH · next due Feb 5, 2027
- PA-25-305NIH Research Project Grant (Parent R01 Clinical Trial Required)NIH · next due Feb 5, 2027
- PAR-24-330Interventions to Reduce Sleep Health Disparities (R01 - Clinical Trials Optional)NIMHD · next due Feb 5, 2027
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.