NIH RFA · OD · R61, R33

RFA-OD-27-005: INCLUDE Project: Clinical Trials Phased Awards for Down syndrome Research (R61/R33 Clinical Trial Required)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Jun 15, 2027Expires Jun 16, 2028

The NIH INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project seeks to improve health and quality-of-life for individuals with Down syndrome. The purpose of this Notice of Funding Opportunity (NOFO) encourages Exploratory/Developmental Phased Innovation (R61/R33) grant applications to support development of clinical trials to treat critical and co-occurring health conditions in individuals with Down syndrome. The proposed research aims should be milestone-driven. The total project period for an application submitted in response to this NOFO may not exceed five years. This NOFO provides support for up to two years (R61 phase) for…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
RFA-OD-27-005
Type
RFA
Activity code
R61R33
Primary institute
OD · NIH Office of the Director
Clinical trials
Required
Posted
May 13, 2026
Opens
Sep 15, 2026
Expires
Jun 16, 2028

RFA-OD-27-005 due dates

2 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for RFA-OD-27-005
NewRenewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
October 15, 2026Not ApplicableNot ApplicableMarch 2027May 2027July 2027
June 15, 2027Not ApplicableNot ApplicableNovember 2027January 2028April 2028
June 15, 2028Not ApplicableNot ApplicableNovember 2028January 2029April 2029

What its predecessor RFA-OD-22-010 funded

RFA-OD-27-005 reissues RFA-OD-22-010. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 5 projects and $6.1M in FY2022–FY2026.

Projects funded

5

Distinct projects, FY2022–FY2026

New awards

3

Type 1 (new project) award records

NIH funding

$6.1M

Award dollars under RFA-OD-22-010, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under RFA-OD-22-010
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202422$994K
FY202541$2.1M
FY202640$3.0M

Institutions with the most funding

  1. Icahn School of Medicine at Mount Sinai$2.1M · 2 projects
  2. Colorado State University$2.0M · 2 projects
  3. Univ of North Carolina Chapel Hill$2.0M · 1 project

Funding institutes

  • NICHD$4.0M · 7
  • NIAMS$2.1M · 3

Activity codes funded

  • R617 records
  • R333 records

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

9 NIH institutes and offices take applications under RFA-OD-27-005. Contact the program officer at the institute that fits your research before applying.

  • OD · NIH Office of the Director
  • NHLBI · National Heart, Lung, and Blood Institute
  • NIA · National Institute on Aging
  • NIAMS · National Institute of Arthritis and Musculoskeletal and Skin Diseases
  • NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
  • NIDCD · National Institute on Deafness and Other Communication Disorders
  • NIDDK · National Institute of Diabetes and Digestive and Kidney Diseases
  • NCATS · National Center for Advancing Translational Sciences
  • NCI · National Cancer Institute

Related notices

NIH lists no related notices for RFA-OD-27-005 yet.

Award terms

Application types allowed
New The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets for the R61 phase and the R33 phase are not limited but need to reflect the actual needs of the proposed project.
Project period
The scope of the proposed project should determine the project period. The maximum period of the combined R61 and R33 phases is 5 years, with up to 2 years for the R61 phase and up to 3 years for the R33 phase. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
NIH intends to commit an estimated 3,000,000 to fund up to 4 awards per year in FY2027, FY2028, and FY2029.The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications. Future year amounts will depend on annual appropriations.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of RFA-OD-22-010.

Other open NOFOs for R61, R33

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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