NIH PAR · NHLBI · R33

PAR-25-025: NHLBI Early Phase Clinical Trials for Therapeutics and/or Diagnostics for HLBS Disorders (R33 CT Required)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsExpires Jan 8, 2027

The objective of this funding opportunity is to support investigator-initiated, phase I clinical trials for diagnostic and therapeutic interventions for heart, lung, blood, and sleep (HLBS) disorders in adults and children. The proposed trial can be single or multisite. Applicants applying for funding under this NOFO should be ready to initiate the clinical trial within the first quarter of the project period. Discussion, submission, and attainment of applicable regulatory (FDA, DSMB, IRB) approvals, and establishment of drug (and placebo, if applicable) supplies, and any necessary third-party agreements should be established by the time of award. If time and support for these and other…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-025
Type
PAR
Activity code
R33
Primary institute
NHLBI · National Heart, Lung, and Blood Institute
Clinical trials
Required
Posted
Dec 5, 2024
Opens
Jan 3, 2025
Expires
Jan 8, 2027

PAR-25-025 due dates

No application due dates remain in the listed cycles. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-025
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
February 03, 2025February 03, 2025May 07, 2025 *July 2025October 2025December 2025
June 04, 2025June 04, 2025September 07, 2025 *November 2025January 2026April 2026
October 02, 2025October 02, 2025January 07, 2026 *March 2026May 2026July 2026
February 03, 2026February 03, 2026May 07, 2026 *July 2026October 2026December 2026
June 04, 2026June 04, 2026Not ApplicableNovember 2026January 2027April 2027
October 02, 2026October 02, 2026Not ApplicableMarch 2027May 2027July 2027

Funded projects

NIH RePORTER lists no awards under PAR-25-025 in FY2022–FY2026. Awards usually appear a few months after the first review cycle.

Participating institutes

2 NIH institutes and offices take applications under PAR-25-025. Contact the program officer at the institute that fits your research before applying.

  • NHLBI · National Heart, Lung, and Blood Institute
  • none

Related notices

  1. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  2. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  3. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Award terms

Application types allowed
NewResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets should not exceed 1,515,000 in direct costs per year.
Project period
The maximum period is 3 years. The scope of the proposed project should determine the requested project period.   NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PAR-24-172.
  • Companion NOFOs: PAR-25-026.

Other open NOFOs for R33

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

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