NIH PAR · NCCIH · R61, R33

PAR-25-449: Mind and Body Interventions to Restore Whole Person Health via Emotional Well-Being Mechanisms (R61/R33 Clinical Trial Required)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Feb 8, 2027Expires Jun 8, 2028

The National Center for Complementary and Integrative Health (NCCIH) announces this Notice of Funding Opportunity (NOFO) to solicit applications for research on how mind and body interventions through psychological and/or physical inputs (e.g., mindfulness meditation, yoga, acupuncture, massage, and other brain and/or body based interventions) impact mechanisms of emotional well-being (EWB) and their associations with whole person health (WPH), consistent with the NIH priority to address the health needs of the American people and improve their well-being. The NOFO will support rigorous and well-powered mechanistic research studies that are supported by strong preliminary data. The studies…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-449
Type
PAR
Activity code
R61R33
Primary institute
NCCIH · National Center for Complementary and Integrative Health
Clinical trials
Required
Posted
Sep 26, 2025
Opens
Oct 7, 2025
Expires
Jun 8, 2028

PAR-25-449 due dates

5 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-449
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
November 07, 2025November 07, 2025Not ApplicableMarch 2026May 2026July 2026
February 09, 2026February 09, 2026Not ApplicableJuly 2026October 2026December 2026
June 08, 2026June 08, 2026Not ApplicableNovember 2026January 2027April 2027
October 07, 2026October 07, 2026Not ApplicableMarch 2027May 2027July 2027
February 08, 2027February 08, 2027Not ApplicableJuly 2027October 2027December 2027
June 08, 2027June 08, 2027Not ApplicableNovember 2027January 2028April 2028
October 07, 2027October 07, 2027Not ApplicableMarch 2028May 2028July 2028
February 08, 2028February 08, 2028Not ApplicableJuly 2028October 2028December 2028
June 07, 2028June 07, 2028Not ApplicableNovember 2028January 2029April 2029

Projects funded under PAR-25-449

NIH RePORTER lists 1 project funded under PAR-25-449 in FY2022–FY2026, with $1.3M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

1

Distinct projects, FY2022–FY2026

New awards

1

Type 1 (new project) award records

NIH funding

$1.3M

Award dollars under PAR-25-449, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-449
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY202611$1.3M

Institutions with the most funding

  1. Oregon Health & Science University$1.3M · 1 project

Funding institutes

  • NCCIH$1.3M · 1

Activity codes funded

  • R611 record

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under PAR-25-449. Contact the program officer at the institute that fits your research before applying.

  • NCCIH · National Center for Complementary and Integrative Health
  • none

Related notices

  1. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  2. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Award terms

Application types allowed
NewRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets need to reflect the actual needs of the proposed project. Application budgets may not exceed 475,000 per year in direct costs. 
Project period
nbsp;The scope of the project should determine the project period for each phase. The maximum period of the combined R61 and R33 phases is 5 years, with up to 2 years for the R61 phase and up to 4 years for the R33 phase.  NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
NCCIH intends to commit 2,000,000 in FY 2026 to fund three awards. Support for subsequent submissions is contingent upon the availability of funds and appropriations.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

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About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

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