NIH PAR · NCCIH · R33
PAR-28-091: Assessing the Feasibility of Incorporating Mechanisms in Multi-site Clinical Trials of Mind and Body Interventions on Whole Person Health Restoration (R33 Clinical Trial Required)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The National Center for Complementary and Integrative Health (NCCIH) announces this Notice of Funding Opportunity (NOFO) to solicit applications for multi-site feasibility trials of complementary and integrative health approaches with physical and/or psychological therapeutic inputs (often called mind and body interventions) to reproduce and translate mechanisms of emotional well-being (EWB) into large-scale clinical trials that advance our understanding of whole person health. These early-phase multi-site trials are essential for 1) demonstrating that the mind and body intervention can be delivered with fidelity across sites; 2) demonstrating reproducibility and rigor in engaging targeted…
- NOFO number
- PAR-28-091
- Type
- PAR
- Activity code
- R33
- Primary institute
- NCCIH · National Center for Complementary and Integrative Health
- Clinical trials
- Required
- Posted
- Oct 15, 2026
- Opens
- Jan 16, 2027
- Expires
- Nov 17, 2029
PAR-28-091 due dates
9 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| February 16, 2027 * | March 16, 2027 * | Not Applicable | July 2027 | October 2027 | December 2027 |
| June 16, 2027 * | July 16, 2027 * | Not Applicable | November 2027 | January 2028 | April 2028 |
| October 16, 2027 * | November 16, 2027 * | Not Applicable | March 2028 | May 2028 | July 2028 |
| February 16, 2028 * | March 16, 2028 * | Not Applicable | July 2028 | October 2028 | December 2028 |
| June 16, 2028 * | July 16, 2028 * | Not Applicable | November 2028 | January 2029 | April 2029 |
| October 16, 2028 * | November 16, 2028 * | Not Applicable | March 2029 | May 2029 | July 2029 |
| February 16, 2029 * | March 16, 2029 * | Not Applicable | July 2029 | October 2029 | December 2029 |
| June 16, 2029 * | July 16, 2029 * | Not Applicable | November 2029 | January 2030 | April 2030 |
| October 16, 2029 * | November 16, 2029 * | Not Applicable | March 2030 | May 2030 | July 2030 |
Funded projects
NIH RePORTER lists no awards under PAR-28-091 in FY2022–FY2026, and it is a new NOFO rather than a reissue. Awards usually appear a few months after the first review cycle.
Participating institutes
2 NIH institutes and offices take applications under PAR-28-091. Contact the program officer at the institute that fits your research before applying.
- NCCIH · National Center for Complementary and Integrative Health
- none
Related notices
NIH lists no related notices for PAR-28-091 yet.
Award terms
- Application types allowed
- New Resubmission Revision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets are not limited but are strongly encouraged not to exceed 500,000 in direct costs per year, reflecting the translational and multi-site nature of this work. Budgets exceeding these guidelines will be considered only in exceptional circumstances and must be extremely well justified.
- Project period
- Applicants are strongly encouraged to request no more than 3 years unless there is a strong scientific justification related to multi-site clinical and mechanistic feasibility assessment and cross-site reproducibility of target engagement. The maximum allowable project period is 4 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted…
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Other open NOFOs for R33
- PAR-25-269NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33 Clinical Trial Required)NCCIH · next due Oct 20, 2026
- PAR-25-270NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required)NCCIH · next due Oct 20, 2026
- PAR-27-045HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required)NCCIH · next due Oct 30, 2026
- PAR-25-449Mind and Body Interventions to Restore Whole Person Health via Emotional Well-Being Mechanisms (R61/R33 Clinical Trial Required)NCCIH · next due Feb 8, 2027
- PAR-25-210Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional)NCCIH · next due Jun 2, 2027
- PAR-25-211Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33 Clinical Trial Optional)NCCIH · next due Jun 2, 2027
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.