NIH PAR · NINDS · R61, R33

PAR-25-053: Translational Neural Devices (R61/R33 - Clinical Trial Optional)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Jan 28, 2027Expires Jan 29, 2027

The purpose of this Notice of Funding Opportunity (NOFO) is to encourage investigators to pursue translational activities and small clinical studies to advance the development of therapeutic, and diagnostic devices for disorders that affect the nervous or neuromuscular systems. Activities supported in this program include implementation of clinical prototype devices, non-clinical safety and efficacy testing, design verification and validation activities, obtaining an Investigational Device Exemption (IDE) for a Significant Risk (SR) study or Institutional Review Board (IRB) approval for a Non-Significant Risk (NSR) study, as well as a subsequent small clinical study. The clinical study is…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-053
Type
PAR
Activity code
R61R33
Primary institute
NINDS · National Institute of Neurological Disorders and Stroke
Clinical trials
Optional
Posted
Oct 29, 2024
Opens
Dec 28, 2024
Expires
Jan 29, 2027

PAR-25-053 due dates

1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-053
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
January 28, 2025January 28, 2025Not ApplicableJuly 2025October 2025December 2025
May 28, 2025May 28, 2025Not ApplicableNovember 2025January 2026April 2026
September 29, 2025September 29, 2025Not ApplicableMarch 2026May 2026July 2026
January 28, 2026January 28, 2026Not ApplicableJuly 2026October 2026December 2026
May 28, 2026May 28, 2026Not ApplicableNovember 2026January 2027April 2027
September 28, 2026September 28, 2026Not ApplicableMarch 2027May 2027July 2027
January 28, 2027January 28, 2027Not ApplicableJuly 2027October 2027December 2027

Projects funded under PAR-25-053

NIH RePORTER lists 5 projects funded under PAR-25-053 in FY2022–FY2026, with $3.1M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

5

Distinct projects, FY2022–FY2026

New awards

5

Type 1 (new project) award records

NIH funding

$3.1M

Award dollars under PAR-25-053, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-053
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY202655$3.1M

Institutions with the most funding

  1. Ohio State University$792K · 1 project
  2. University of Colorado Denver$723K · 1 project
  3. Cleveland VA Medical Research/Ed/Fdn$572K · 1 project
  4. Johns Hopkins University$532K · 1 project
  5. Washington University$493K · 1 project

Funding institutes

  • NINDS$3.1M · 5

Activity codes funded

  • R615 records

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under PAR-25-053. Contact the program officer at the institute that fits your research before applying.

  • NINDS · National Institute of Neurological Disorders and Stroke
  • none

Related notices

  1. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  2. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  3. Aug 5, 2022

    Implementation Details for the NIH Data Management and Sharing Policy.

Award terms

Application types allowed
NewResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets are not limited but need to reflect the actual needs of the proposed project. In all cases, applicants should propose a budget that is reasonable and appropriate for completion of the research project. 
Project period
The proposed project period for the R61 phase must not exceed 2 years. The proposed project period for the R33 phase must not exceed 4 years. The total duration of the R61 and R33 may not exceed 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PAR-24-151.

Other open NOFOs for R61, R33

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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