NIH PAR · NINDS · R61, R33

PAR-25-024: Development of Biomarkers or Composite Biomarkers for Neurological and Neuromuscular Disorders (R61/R33 - Clinical Trial Optional)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Oct 20, 2026Expires Jan 8, 2028

The overarching purpose of this Funding Opportunity Announcement (FOA) is to promote the discovery and/or early evaluation of strong candidate biomarkers and biomarker signatures that can be used as tools to facilitate the clinical development of neurotherapeutics and their use in clinical practice. Specifically, the focus of this FOA is on the identification and initial biological, analytical and clinical evaluation of biomarkers and biomarker signatures for neurological and neuromuscular disorders. Although research supported by this FOA can include animal studies, it must also include preliminary human evaluation using carefully standardized human samples or datasets. The goal of this…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-024
Type
PAR
Activity code
R61R33
Primary institute
NINDS · National Institute of Neurological Disorders and Stroke
Clinical trials
Optional
Posted
Oct 28, 2024
Opens
Jan 21, 2025
Expires
Jan 8, 2028

PAR-25-024 due dates

4 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-024
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
February 21, 2025February 21, 2025May 07, 2025 *July 2025October 2025December 2025
June 20, 2025June 20, 2025September 07, 2025 *November 2025January 2026April 2026
October 20, 2025October 20, 2025January 07, 2026 *March 2026May 2026July 2026
February 20, 2026February 20, 2026May 07, 2026 *July 2026October 2026December 2026
June 22, 2026June 22, 2026Not ApplicableNovember 2026January 2027April 2027
October 20, 2026October 20, 2026Not ApplicableMarch 2027May 2027July 2027
February 22, 2027February 22, 2027Not ApplicableJuly 2027October 2027December 2027
June 21, 2027June 21, 2027Not ApplicableNovember 2027January 2028April 2028
October 20, 2027October 20, 2027Not ApplicableMarch 2028May 2028July 2028

Projects funded under PAR-25-024

NIH RePORTER lists 6 projects funded under PAR-25-024 in FY2022–FY2026, with $8.5M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

6

Distinct projects, FY2022–FY2026

New awards

6

Type 1 (new project) award records

NIH funding

$8.5M

Award dollars under PAR-25-024, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-024
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY202666$8.5M

Institutions with the most funding

  1. University of California at Davis$2.3M · 1 project
  2. Massachusetts General Hospital$2.0M · 1 project
  3. University of Minnesota$1.8M · 1 project
  4. Emory University$927K · 1 project
  5. University of Texas Hlth Sci Ctr Houston$722K · 1 project
  6. Children's Hosp of Philadelphia$707K · 1 project

Funding institutes

  • NINDS$8.5M · 6

Activity codes funded

  • R616 records

Most recent new awards

What its predecessor PAR-22-089 funded

PAR-25-024 reissues PAR-22-089. Its funding history is the best guide to who wins under this program: 5 projects and $7.9M in FY2022–FY2026.

Projects funded

5

Distinct projects, FY2022–FY2026

New awards

5

Type 1 (new project) award records

NIH funding

$7.9M

Award dollars under PAR-22-089, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-22-089
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202322$1.3M
FY202442$2.8M
FY202541$2.8M
FY202620$1.1M

Institutions with the most funding

  1. Massachusetts General Hospital$2.2M · 1 project
  2. Boston Children's Hospital$2.0M · 1 project
  3. Hugo W. Moser Res Inst Kennedy Krieger$1.6M · 1 project
  4. Boston University Medical Campus$1.4M · 1 project
  5. University of Rochester$823K · 1 project

Funding institutes

  • NINDS$7.9M · 12

Activity codes funded

  • R6112 records

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under PAR-25-024. Contact the program officer at the institute that fits your research before applying.

  • NINDS · National Institute of Neurological Disorders and Stroke
  • none

Related notices

  1. Jan 28, 2026 · NOT-OD-26-029

    NIH Removing AIDS Application Due Dates from NOFOs. See Notice NOT-OD-26-029.

  2. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  3. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  4. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy.

Notices of Special Interest (NOSIs)

NIH has attached 1 NOSI to PAR-25-024; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.

Award terms

Application types allowed
NewResubmissionRevision NewResubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets are not limited but need to reflect the actual needs of the proposed project.
Project period
The R61 phase can be from 1-3 years and the R33 phase can be 1-3 years, with a total project duration of no more than 5 years NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PAR-22-089.

Other open NOFOs for R61, R33

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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