NIH PAR · NINDS · R61, R33

PAR-25-060: Innovation Grants to Nurture Initial Translational Efforts (IGNITE): Development and Validation of Model Systems to Facilitate Neurotherapeutic Discovery (R61/R33 Clinical Trial Not Allowed)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Oct 20, 2026Expires Oct 21, 2027

This funding opportunity announcement (FOA) encourages the development and validation of animal models and human/animal tissue ex vivo systems that recapitulate the phenotypic and physiologic characteristics of a defined neurological or neuromuscular disorder. The goal of this FOA is to promote a significant improvement in the translational relevance of animal models or ex vivo systems that will be utilized to facilitate future development of neurotherapeutics. Ideally, models proposed for this FOA would have the potential to provide feasible and meaningful assessments of efficacy following therapeutic intervention that would be applicable in both preclinical and clinical settings. This FOA…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-060
Type
PAR
Activity code
R61R33
Primary institute
NINDS · National Institute of Neurological Disorders and Stroke
Clinical trials
Not Allowed
Posted
Oct 22, 2024
Opens
Jan 18, 2025
Expires
Oct 21, 2027

PAR-25-060 due dates

4 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-060
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
February 18, 2025February 18, 2025Not ApplicableJuly 2025October 2025December 2025
June 18, 2025June 18, 2025Not ApplicableNovember 2025January 2026April 2026
October 20, 2025October 20, 2025Not ApplicableMarch 2026May 2026July 2026
February 18, 2026February 18, 2026Not ApplicableJuly 2026October 2026December 2026
June 18, 2026June 18, 2026Not ApplicableNovember 2026January 2027April 2027
October 20, 2026October 20, 2026Not ApplicableMarch 2027May 2027July 2027
February 18, 2027February 18, 2027Not ApplicableJuly 2027October 2027December 2027
June 18, 2027June 18, 2027Not ApplicableNovember 2027January 2028April 2028
October 20, 2027October 20, 2027Not ApplicableMarch 2028May 2028July 2028

Projects funded under PAR-25-060

NIH RePORTER lists 4 projects funded under PAR-25-060 in FY2022–FY2026, with $1.9M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

4

Distinct projects, FY2022–FY2026

New awards

4

Type 1 (new project) award records

NIH funding

$1.9M

Award dollars under PAR-25-060, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-060
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY202644$1.9M

Institutions with the most funding

  1. Henry Ford Health + Michigan State University Health Sciences$715K · 1 project
  2. University of Virginia$459K · 1 project
  3. University of Texas Hlth Sci Ctr Houston$392K · 1 project
  4. University of Florida$362K · 1 project

Funding institutes

  • NINDS$1.9M · 4

Activity codes funded

  • R614 records

Most recent new awards

What its predecessor PAR-21-123 funded

PAR-25-060 reissues PAR-21-123. Its funding history is the best guide to who wins under this program: 27 projects and $15.5M in FY2022–FY2026.

Projects funded

27

Distinct projects, FY2022–FY2026

New awards

17

Type 1 (new project) award records

NIH funding

$15.5M

Award dollars under PAR-21-123, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-21-123
Fiscal yearAward recordsNew awardsFunding
FY202233$1.2M
FY202396$3.4M
FY2024125$4.8M
FY2025103$3.9M
FY202660$2.2M

Institutions with the most funding

  1. University of Michigan at Ann Arbor$1.8M · 3 projects
  2. Jackson Laboratory$1.3M · 2 projects
  3. Upstate Medical University$1.2M · 2 projects
  4. Massachusetts General Hospital$1.2M · 2 projects
  5. Case Western Reserve University$1.2M · 2 projects
  6. Utah State Higher Education System--University of Utah$1.1M · 2 projects
  7. Virginia Commonwealth University$1.1M · 2 projects
  8. Duke University$1.0M · 2 projects

Funding institutes

  • NINDS$15.5M · 40

Activity codes funded

  • R6124 records
  • R3316 records

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under PAR-25-060. Contact the program officer at the institute that fits your research before applying.

  • NINDS · National Institute of Neurological Disorders and Stroke
  • none

Related notices

  1. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  2. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  3. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy.

Notices of Special Interest (NOSIs)

NIH has attached 1 NOSI to PAR-25-060; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.

Award terms

Application types allowed
NewResubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Direct Costs cannot exceed 499,000 in any one year and cumulative direct costs for the three year project cannot exceed 750,000.
Project period
The total project period for a combined R61/R33 application submitted in response to this NOFO may not exceed three years, with no more than two years for the R61 phase and no more than two years for the R33 phase. For example, a project could have a 1-year R61 and a 2-year R33 or could have a 2-year R61 and a 1-year R33.)  NIH grants policies as described in the NIH Grants Policy Statement…
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

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About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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