NIH RFA · NIDCD · R61

RFA-DC-27-004: BRAIN Initiative: Exploratory Research Opportunities Using Invasive Neural Recording and Stimulating Technologies in the Human Brain (R61 Clinical Trial Not Allowed)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Feb 11, 2027Expires Feb 12, 2027

Invasive surgical procedures in humans offer the unique opportunity to intracranially record and stimulate neuronal activity within precisely localized brain structures, enabling high-impact human neuroscience investigations. This NOFO seeks exploratory research projects, from newly formed or established multi-disciplinary teams, to understand how dynamic activity of single cells and ensembles of neurons in spatially organized networks gives rise to the internal states we experience as sensations, perceptions, emotions, thoughts, and memories, and to observable motor and social behaviors. The research should be proposed as exploratory research and planning activities to establish…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
RFA-DC-27-004
Type
RFA
Activity code
R61
Primary institute
NIDCD · National Institute on Deafness and Other Communication Disorders
Clinical trials
Not Allowed
Posted
May 4, 2026
Opens
May 9, 2026
Expires
Feb 12, 2027

RFA-DC-27-004 due dates

1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for RFA-DC-27-004
NewRenewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
June 09, 2026June 09, 2026Not ApplicableNovember 2026January 2027April 2027
February 11, 2027February 11, 2027Not ApplicableJuly 2027October 2027December 2027

What its predecessor RFA-DC-24-001 funded

RFA-DC-27-004 reissues RFA-DC-24-001. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 4 projects and $8.3M in FY2022–FY2026.

Projects funded

4

Distinct projects, FY2022–FY2026

New awards

4

Type 1 (new project) award records

NIH funding

$8.3M

Award dollars under RFA-DC-24-001, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under RFA-DC-24-001
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202411$1.0M
FY202543$3.8M
FY202640$3.5M

Institutions with the most funding

  1. University of Colorado Denver$2.8M · 1 project
  2. Cedars-Sinai Medical Center$2.0M · 1 project
  3. New York University School of Medicine$2.0M · 1 project
  4. University of Chicago$1.5M · 1 project

Funding institutes

  • NIDCD$8.3M · 9

Activity codes funded

  • R619 records

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

10 NIH institutes and offices take applications under RFA-DC-27-004. Contact the program officer at the institute that fits your research before applying.

  • NIDCD · National Institute on Deafness and Other Communication Disorders
  • NEI · National Eye Institute
  • NIA · National Institute on Aging
  • NIAAA · National Institute on Alcohol Abuse and Alcoholism
  • NIBIB · National Institute of Biomedical Imaging and Bioengineering
  • NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
  • NIDA · National Institute on Drug Abuse
  • NIMH · National Institute of Mental Health
  • NINDS · National Institute of Neurological Disorders and Stroke
  • NCCIH · National Center for Complementary and Integrative Health

Related notices

NIH lists no related notices for RFA-DC-27-004 yet.

Award terms

Application types allowed
New Resubmission Revision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets may not exceed 700,000 Direct Costs, exclusive of facilities and administrative costs for consortia) in any single year.
Project period
The scope of the proposed project should determine the project period. The maximum project period is 3 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
Issuing IC and partner components intend to commit an estimated total of 6M total costs to fund approximately 5 awards per receipt date.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of RFA-DC-24-001.

Other open NOFOs for R61

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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