NIH PAR · NCCIH · R33

PAR-25-210: Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Jun 2, 2027Expires Jun 3, 2027

The purpose of this notice of funding opportunity (NOFO) is to support highly innovative mechanistic research to accelerate precision probiotic interventions. Specifically, this NOFO solicits R33 applications that will characterize person-specific features affecting probiotic responses to identify subgroups of probiotic responders and to enhance probiotic clinical outcomes. The ultimate goal of this NOFO is to identify, understand, and develop strategies to address barriers in precision probiotic therapies to account for the heterogenicity in humans that causes inconsistent probiotic responses. This NOFO will support studies to assess the ability of the unique patterns of host biology…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-210
Type
PAR
Activity code
R33
Primary institute
NCCIH · National Center for Complementary and Integrative Health
Clinical trials
Optional
Posted
Oct 31, 2024
Opens
May 2, 2025
Expires
Jun 3, 2027

PAR-25-210 due dates

1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-210
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
June 02, 2025July 02, 2025Not ApplicableNovember 2025January 2026April 2026
February 02, 2026February 02, 2026Not ApplicableJuly 2026October 2026December 2026
October 01, 2026October 01, 2026Not ApplicableMarch 2027May 2027July 2027
June 02, 2027June 02, 2027Not ApplicableNovember 2027January 2028April 2028

Projects funded under PAR-25-210

NIH RePORTER lists 1 project funded under PAR-25-210 in FY2022–FY2026, with $2.2M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

1

Distinct projects, FY2022–FY2026

New awards

1

Type 1 (new project) award records

NIH funding

$2.2M

Award dollars under PAR-25-210, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-210
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY202611$2.2M

Institutions with the most funding

  1. University of Chicago$2.2M · 1 project

Funding institutes

  • NCCIH$2.2M · 1

Activity codes funded

  • R331 record

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

5 NIH institutes and offices take applications under PAR-25-210. Contact the program officer at the institute that fits your research before applying.

  • NCCIH · National Center for Complementary and Integrative Health
  • NIA · National Institute on Aging
  • NIDCR · National Institute of Dental and Craniofacial Research
  • NCI · National Cancer Institute
  • ORWH

Related notices

  1. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  2. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  3. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Award terms

Application types allowed
NewResubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
The application budget must not exceed 350,000 in direct costs per year. 
Project period
The scope of the project should determine the project period. The total project period request may not exceed 4 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PAR-24-239.
  • Companion NOFOs: PAR-25-211.

Other open NOFOs for R33

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

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