NIH PAR · NCCIH · R61, R33
PAR-27-045: HEAL Initiative: Whole Joint Health Program (R61/R33 Clinical Trial Required)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The NIH Helping to End Addiction Long-term ® (HEAL) Initiative is releasing this Notice of Funding Opportunity (NOFO) to support a phased mechanistic clinical research program focusing on understudied biological mechanisms that drive joint pain. The phased projects supported by this program (of up to five years total in duration) will first identify and validate multi-tissue mechanisms underlying joint pain, then test non-pharmacologic or multimodal interventions that directly target these mechanisms. The initiative responds to priorities identified in the 2023 HEAL Whole Joint Pain Workshop and supports the broader goals of the NIH HEAL Initiative and the Make America Healthy Again vision…
- NOFO number
- PAR-27-045
- Type
- PAR
- Activity code
- R61R33
- Primary institute
- NCCIH · National Center for Complementary and Integrative Health
- Clinical trials
- Required
- Posted
- Sep 28, 2026
- Opens
- Sep 30, 2026
- Expires
- Oct 31, 2026
PAR-27-045 due dates
1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| October 30, 2026 | Not Applicable | Not Applicable | March 2027 | May 2027 | July 2027 |
Funded projects
NIH RePORTER lists no awards under PAR-27-045 in FY2022–FY2026, and it is a new NOFO rather than a reissue. Awards usually appear a few months after the first review cycle.
Participating institutes
7 NIH institutes and offices take applications under PAR-27-045. Contact the program officer at the institute that fits your research before applying.
- NCCIH · National Center for Complementary and Integrative Health
- NIA · National Institute on Aging
- NIAAA · National Institute on Alcohol Abuse and Alcoholism
- NIAMS · National Institute of Arthritis and Musculoskeletal and Skin Diseases
- NIBIB · National Institute of Biomedical Imaging and Bioengineering
- NIDCR · National Institute of Dental and Craniofacial Research
- NINDS · National Institute of Neurological Disorders and Stroke
Related notices
NIH lists no related notices for PAR-27-045 yet.
Award terms
- Application types allowed
- New The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets are not limited but need to reflect the actual needs of the proposed project. However, it is strongly recommended that applicants do not request a budget of more than 500k in direct costs per year for the R61 phase. For applications that propose a 3-year R33 project phase, it is strongly recommended that they budget no more than 700k in direct costs per year. For applications…
- Project period
- The scope of the project should determine the project period for each phase. The maximum period of the combined R61 and R33 phases is 5 years, with 2 or 3 years for the R61 phase and 2 or 3 years for the R33 phase. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Other open NOFOs for R61, R33
- PAR-25-269NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33 Clinical Trial Required)NCCIH · next due Oct 20, 2026
- PAR-25-270NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required)NCCIH · next due Oct 20, 2026
- PAR-25-449Mind and Body Interventions to Restore Whole Person Health via Emotional Well-Being Mechanisms (R61/R33 Clinical Trial Required)NCCIH · next due Feb 8, 2027
- PAR-28-091Assessing the Feasibility of Incorporating Mechanisms in Multi-site Clinical Trials of Mind and Body Interventions on Whole Person Health Restoration (R33 Clinical Trial Required)NCCIH · next due Feb 16, 2027
- PAR-25-210Enhancing Mechanistic Research on Precision Probiotic Therapies (R33 Clinical Trial Optional)NCCIH · next due Jun 2, 2027
- PAR-25-211Enhancing Mechanistic Research on Precision Probiotic Therapies (R61/R33 Clinical Trial Optional)NCCIH · next due Jun 2, 2027
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.