NIH PAR · NIDA · R34
PAR-25-378: Intervention Research to Improve Native American Health (R34 Clinical Trial Optional)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The purpose of this notice of funding opportunity (NOFO) is to support research on interventions to improve health in Native American (NA) populations. This includes 1) etiologic research, where there is a significant gap in knowledge, that will directly inform intervention development or adaptations, 2) research that develops, adapts, or tests the efficacy or effectiveness of health promotion and disease prevention interventions, 3) research that tests culturally informed treatment or recovery interventions and 4) where a sufficient body of knowledge on intervention efficacy exists, research on dissemination and implementation that develops and tests strategies to overcome barriers to the…
- NOFO number
- PAR-25-378
- Type
- PAR
- Activity code
- R34
- Primary institute
- NIDA · National Institute on Drug Abuse
- Clinical trials
- Optional
- Posted
- Jan 22, 2025
- Opens
- Sep 21, 2025
- Expires
- Jan 8, 2027
PAR-25-378 due dates
1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Application Due Date(s) | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| October 21, 2025 | October 21, 2025 | January 07, 2026 * | March 2026 | May 2026 | July 2026 |
| October 21, 2026 | October 21, 2026 | Not Applicable | March 2027 | May 2027 | July 2027 |
Projects funded under PAR-25-378
NIH RePORTER lists 2 projects funded under PAR-25-378 in FY2022–FY2026, with $770K in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.
Projects funded
2
Distinct projects, FY2022–FY2026
New awards
2
Type 1 (new project) award records
NIH funding
$770K
Award dollars under PAR-25-378, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 0 | 0 | $0 |
| FY2026 | 2 | 2 | $770K |
Institutions with the most funding
- University of Oklahoma Hlth Sciences Ctr$653K · 1 project
- University of Michigan at Ann Arbor$117K · 1 project
Funding institutes
- NINR$653K · 1
- NIAAA$117K · 1
Activity codes funded
- R342 records
Most recent new awards
- SPIRIT: A Culturally Grounded Supportive Care Intervention for Chickasaw Nation Patients with Cancer (opens NIH RePORTER)
University of Oklahoma Hlth Sciences Ctr · 1R34NR022364-01 · NINR · Notice Sep 2, 2026
$653KR34
- Community–Led Adaptation and Implementation of SBIRT for Alcohol in Tribal Primary Care (opens NIH RePORTER)
University of Michigan at Ann Arbor · 1R34AA033516-01 · NIAAA · Notice Sep 2, 2026
$117KR34
What its predecessor PAR-23-285 funded
PAR-25-378 reissues PAR-23-285. Its funding history is the best guide to who wins under this program: 2 projects and $1.2M in FY2022–FY2026.
Projects funded
2
Distinct projects, FY2022–FY2026
New awards
2
Type 1 (new project) award records
NIH funding
$1.2M
Award dollars under PAR-23-285, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 2 | 2 | $917K |
| FY2026 | 1 | 0 | $270K |
Institutions with the most funding
- Pennsylvania State Univ Hershey Med Ctr$724K · 1 project
- Utah State Higher Education System--University of Utah$462K · 1 project
Funding institutes
- NINR$724K · 1
- NCCIH$462K · 2
Activity codes funded
- R343 records
Most recent new awards
- Using a conversation game to engage Native American Washoe tribe members in advance care planning: preparation for a clinical trial (opens NIH RePORTER)
Pennsylvania State Univ Hershey Med Ctr · 1R34NR021940-01 · NINR · Notice Sep 15, 2025
$724KR34
- Waning Moon: A Whole Person Health Intervention Designed by and for Urban Menopausal American Indian/Alaska Native Women (opens NIH RePORTER)
Utah State Higher Education System--University of Utah · 1R34AT013448-01 · NCCIH · Notice Aug 26, 2025
$193KR34
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
13 NIH institutes and offices take applications under PAR-25-378. Contact the program officer at the institute that fits your research before applying.
- NIDA · National Institute on Drug Abuse
- NIA · National Institute on Aging
- NIAAA · National Institute on Alcohol Abuse and Alcoholism
- NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NIDCR · National Institute of Dental and Craniofacial Research
- NIEHS · National Institute of Environmental Health Sciences
- NIMH · National Institute of Mental Health
- NINR · National Institute of Nursing Research
- NCCIH · National Center for Complementary and Integrative Health
- ODP
- OBSSR
- ORWH
- THRO
Related notices
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy.
Notices of Special Interest (NOSIs)
NIH has attached 1 NOSI to PAR-25-378; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.
Award terms
- Application types allowed
- NewResubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Applicants may request direct costs of up to 450,000 for three years. Although variations from year to year are permissible, in no case may any year be more than 225,000 in direct costs, and total direct costs for the entire project period may not exceed 450,000.
- Project period
- The scope of the proposed project should determine the project period. The maximum project period is 3 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAR-23-285.
- Companion NOFOs: PAR-25-379.
Other open NOFOs for R34
- PAR-24-329Development and Testing of Novel Interventions to Improve HIV Prevention, Treatment, and Program Implementation for People Who Use Substances (R34 Clinical Trial Required)NIDA · next due Oct 16, 2026
- PAR-25-100Pilot Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders (R34 Clinical Trial Optional)NIDA · next due Oct 16, 2026
- PAR-25-358NEI Clinical Research Study Planning Grant Program (R34 Clinical Trial Not Allowed)NEI · next due Oct 16, 2026
- PAR-25-284Innovative Pilot Mental Health Services Research Not Involving Clinical Trials (R34 Clinical Trial Not Allowed)NIMH · next due Oct 16, 2026
- PAR-25-032NHLBI Clinical Trial Pilot Studies (R34 Clinical Trial Optional)NHLBI · next due Oct 16, 2026
- PAR-25-159Prevention and Intervention Approaches for Fetal Alcohol Spectrum Disorders (R34 Clinical Trial Optional)NIAAA · next due Oct 16, 2026
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.