NIH PAR · NHLBI · R34

PAR-25-032: NHLBI Clinical Trial Pilot Studies (R34 Clinical Trial Optional)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Oct 16, 2026Expires Jan 8, 2027

This Notice of Funding Opportunity Announcement (NOFO) intends to supports studies that are both necessary and sufficient to inform the planning of a Phase II-IV clinical trial within NHLBI's mission. The NHLBI expects that applications to this NOFO will describe the planned clinical trial and in so doing demonstrate that the proposed (R34) research is scientifically necessary to design or plan the subsequent trial. Furthermore, this NOFO will support research projects that are designed to provide results that will be sufficient to inform the future trial without further studies. The planned Phase II, III, or IV trial must be primarily intended to test the efficacy, safety, clinical…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-032
Type
PAR
Activity code
R34
Primary institute
NHLBI · National Heart, Lung, and Blood Institute
Clinical trials
Optional
Posted
Dec 18, 2024
Opens
Jan 16, 2025
Expires
Jan 8, 2027

PAR-25-032 due dates

1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-032
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
February 16, 2025March 16, 2025 *May 07, 2025 *July 2025October 2025December 2025
June 16, 2025July 16, 2025 *September 07, 2025 *November 2025January 2026April 2026
October 16, 2025November 16, 2025 *January 07, 2026 *March 2026May 2026July 2026
February 16, 2026March 16, 2026 *May 07, 2026 *July 2026October 2026December 2026
June 16, 2026July 16, 2026 *Not ApplicableNovember 2026January 2027April 2027
October 16, 2026November 16, 2026 *Not ApplicableMarch 2027May 2027July 2027

Projects funded under PAR-25-032

NIH RePORTER lists 20 projects funded under PAR-25-032 in FY2022–FY2026, with $5.6M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

20

Distinct projects, FY2022–FY2026

New awards

20

Type 1 (new project) award records

NIH funding

$5.6M

Award dollars under PAR-25-032, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-032
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY20262020$5.6M

Institutions with the most funding

  1. Univ of Massachusetts Med Sch Worcester$745K · 1 project
  2. University of Mississippi Med Ctr$333K · 1 project
  3. University of Colorado Denver$304K · 1 project
  4. University of Virginia$284K · 1 project
  5. Sloan-Kettering Inst Can Research$282K · 1 project
  6. Yale University$279K · 1 project
  7. Trustees of Indiana University$277K · 1 project
  8. Washington University$272K · 1 project

Funding institutes

  • NHLBI$5.6M · 20

Activity codes funded

  • R3420 records

Most recent new awards

What its predecessor PAR-24-049 funded

PAR-25-032 reissues PAR-24-049. Its funding history is the best guide to who wins under this program: 14 projects and $8.7M in FY2022–FY2026.

Projects funded

14

Distinct projects, FY2022–FY2026

New awards

14

Type 1 (new project) award records

NIH funding

$8.7M

Award dollars under PAR-24-049, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-24-049
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY20251414$4.5M
FY2026140$4.2M

Institutions with the most funding

  1. University of California, San Francisco$1.4M · 2 projects
  2. Columbia University Health Sciences$790K · 1 project
  3. New York University School of Medicine$778K · 1 project
  4. University of Texas Hlth Science Center$755K · 1 project
  5. Cleveland Clinic Lerner Com-Cwru$725K · 1 project
  6. George Washington University$713K · 1 project
  7. Medical University of South Carolina$698K · 1 project
  8. Brigham and Women's Hospital$549K · 1 project

Funding institutes

  • NHLBI$8.7M · 28

Activity codes funded

  • R3428 records

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under PAR-25-032. Contact the program officer at the institute that fits your research before applying.

  • NHLBI · National Heart, Lung, and Blood Institute
  • none

Related notices

  1. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  2. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  3. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Award terms

Application types allowed
NewResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets may request up to 450,000 in direct costs over a three-year period. Application budgets may request up to 225,000 in direct costs in any single year.
Project period
The maximum project period is 3 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PAR-24-049.

Other open NOFOs for R34

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

NIH grant searchLook up awards by topic, PI, or institution.Find funded PIsInvestigators with recent NIH awards in your research area.Institute fit by topicWhich NIH institutes and institutions lead a research area.Funding trendsYear-by-year NIH award totals for any keyword.