NIH PAR · NIMH · R21
PAR-25-282: Mood and Psychosis Symptoms during the Menopause Transition (R21 Clinical Trial Optional)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The purpose of this Notice of Funding Opportunity (NOFO) is to advance translational research to better understand the emergence and worsening of mood and psychotic disorders (e.g., perimenopausal depression (PMD), generalized anxiety disorder, bipolar disorder and schizophrenia) during the menopause transition (MT) in an effort to identity targets for future development of novel treatment interventions. This funding opportunity aims to advance novel and innovative translational research to better comprehend the underlying neurobiological and behavioral mechanisms of mood and psychosis disorders and related symptoms during MT. This funding opportunity also encourages interdisciplinary…
- NOFO number
- PAR-25-282
- Type
- PAR
- Activity code
- R21
- Primary institute
- NIMH · National Institute of Mental Health
- Clinical trials
- Optional
- Posted
- Nov 22, 2024
- Opens
- Jan 16, 2025
- Expires
- Jan 8, 2028
PAR-25-282 due dates
4 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Application Due Date(s) | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| February 16, 2025 | March 16, 2025 * | Not Applicable | July 2025 | October 2025 | December 2025 |
| June 16, 2025 | July 16, 2025 * | Not Applicable | November 2025 | January 2026 | April 2026 |
| October 16, 2025 | November 16, 2025 * | Not Applicable | March 2026 | May 2026 | July 2026 |
| February 16, 2026 | March 16, 2026 * | Not Applicable | July 2026 | October 2026 | December 2026 |
| June 16, 2026 | July 16, 2026 * | Not Applicable | November 2026 | January 2027 | April 2027 |
| October 16, 2026 | November 16, 2026 * | Not Applicable | March 2027 | May 2027 | July 2027 |
| February 16, 2027 | March 16, 2027 * | Not Applicable | July 2027 | October 2027 | December 2027 |
| June 16, 2027 | July 16, 2027 * | Not Applicable | November 2027 | January 2028 | April 2028 |
| October 16, 2027 | November 16, 2027 * | Not Applicable | March 2028 | May 2028 | July 2028 |
Funded projects
NIH RePORTER lists no awards under PAR-25-282 in FY2022–FY2026. Awards usually appear a few months after the first review cycle.
Participating institutes
2 NIH institutes and offices take applications under PAR-25-282. Contact the program officer at the institute that fits your research before applying.
- NIMH · National Institute of Mental Health
- ORWH
Related notices
Mar 31, 2025 · NOT-OD-24-084
This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Notices of Special Interest (NOSIs)
NIH has attached 1 NOSI to PAR-25-282; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.
Award terms
- Application types allowed
- New Resubmisson of RFA-MH-21-106, PAR-22-036, PAR-23-102, and PAR-25-281Revision of RFA-MH-21-106, PAR-22-036 and PAR-23-102 The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- The combined budget for direct costs for the two year project period may not exceed 275,000. No more than 200,000 may be requested in any single year.
- Project period
- The scope of the proposed project should determine the project period. The maximum project period is 2 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAR-23-102.
- Companion NOFOs: PAR-25-281.
Other open NOFOs for R21
- PAR-25-291Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R21 Clinical Trial Optional)NIMH · next due Oct 16, 2026
- PAR-25-286Neuromodulation/Neurostimulation Device Development for Mental Health Applications (R21 Clinical Trial Not Allowed)NIMH · next due Oct 16, 2026
- RFA-MH-27-125Mechanistic Evaluation of Therapeutic Targets derived from Treatable Traits to Improve CNS Outcomes in People with HIV (R21/R33 Clinical Trial Not Allowed)NIMH · next due Nov 9, 2026
- PA-25-304NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed)NIH · next due Oct 16, 2026
- PA-25-306NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required)NIH · next due Oct 16, 2026
- PAR-25-143Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)NCI · next due Oct 16, 2026
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.