NIH PAR · NIMH · R21

PAR-25-286: Neuromodulation/Neurostimulation Device Development for Mental Health Applications (R21 Clinical Trial Not Allowed)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Oct 16, 2026Expires Jan 8, 2028

The purpose of this Notice of Funding Opportunity (NOFO) is to encourage applications seeking to develop the next generation of brain stimulation devices for treating mental health disorders. Applications are sought that will either 1) develop novel brain stimulation devices or 2) significantly enhance, by means of hardware/software improvements, the effectiveness of brain stimulation devices that are currently U.S. Food and Drug Administration (FDA)-approved or cleared. Novel devices should move beyond existing electrical/magnetic stimulation and develop new stimulation techniques capable of increased spatiotemporal precision as well as multi-focal, closed-loop approaches. Applications…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-286
Type
PAR
Activity code
R21
Primary institute
NIMH · National Institute of Mental Health
Clinical trials
Not Allowed
Posted
Nov 21, 2024
Opens
Jan 16, 2025
Expires
Jan 8, 2028

PAR-25-286 due dates

4 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-286
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
February 16, 2025March 16, 2025 *Not ApplicableJuly 2025October 2025December 2025
June 16, 2025July 16, 2025 *Not ApplicableNovember 2025January 2026April 2026
October 16, 2025November 16, 2025 *Not ApplicableMarch 2026May 2026July 2026
February 16, 2026March 16, 2026 *Not ApplicableJuly 2026October 2026December 2026
June 16, 2026July 16, 2026 *Not ApplicableNovember 2026January 2027April 2027
October 16, 2026November 16, 2026 *Not ApplicableMarch 2027May 2027July 2027
February 16, 2027March 16, 2027 *Not ApplicableJuly 2027October 2027December 2027
June 16, 2027July 16, 2027 *Not ApplicableNovember 2027January 2028April 2028
October 16, 2027November 16, 2027 *Not ApplicableMarch 2028May 2028July 2028

Projects funded under PAR-25-286

NIH RePORTER lists 1 project funded under PAR-25-286 in FY2022–FY2026, with $454K in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

1

Distinct projects, FY2022–FY2026

New awards

1

Type 1 (new project) award records

NIH funding

$454K

Award dollars under PAR-25-286, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-286
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY202611$454K

Institutions with the most funding

  1. Massachusetts General Hospital$454K · 1 project

Funding institutes

  • NIMH$454K · 1

Activity codes funded

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under PAR-25-286. Contact the program officer at the institute that fits your research before applying.

  • NIMH · National Institute of Mental Health
  • none

Related notices

  1. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  2. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  3. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Notices of Special Interest (NOSIs)

NIH has attached 1 NOSI to PAR-25-286; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.

Award terms

Application types allowed
NewResubmissionRevision Resubmission of PAR-22-038 and this NOFORevision of nbsp;PAR-22-038 and this NOFO  The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
The combined budget for direct costs for the two-year project period may not exceed 275,000. No more than 200,000 may be requested in any single year.
Project period
The total project period may not exceed 2 years.  NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PAR-22-038.
  • Companion NOFOs: PAR-25-287.

Other open NOFOs for R21

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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