NIH PAR · NIMH · R01
PAR-25-281: Mood and Psychosis Symptoms during the Menopause Transition (R01 Clinical Trial Optional)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The purpose of this Notice of Funding Opportunity (NOFO) is to advance translational research to better understand the emergence and worsening of mood and psychotic disorders (e.g., perimenopausal depression (PMD), generalized anxiety disorder, bipolar disorder and schizophrenia) during the menopause transition (MT) in an effort to identity targets for future development of novel treatment interventions. This funding opportunity aims to advance novel and innovative translational research to better comprehend the underlying neurobiological and behavioral mechanisms of mood and psychosis disorders and related symptoms during MT. This funding opportunity also encourages interdisciplinary…
- NOFO number
- PAR-25-281
- Type
- PAR
- Activity code
- R01
- Primary institute
- NIMH · National Institute of Mental Health
- Clinical trials
- Optional
- Posted
- Nov 22, 2024
- Opens
- Jan 5, 2025
- Expires
- Jan 8, 2028
PAR-25-281 due dates
3 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Application Due Date(s) | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| February 05, 2025 | March 05, 2025 * | Not Applicable | July 2025 | October 2025 | December 2025 |
| June 05, 2025 | July 05, 2025 * | Not Applicable | November 2025 | January 2026 | April 2026 |
| October 05, 2025 | November 05, 2025 * | Not Applicable | March 2026 | May 2026 | July 2026 |
| February 05, 2026 | March 05, 2026 * | Not Applicable | July 2026 | October 2026 | December 2026 |
| June 05, 2026 | July 05, 2026 * | Not Applicable | November 2026 | January 2027 | April 2027 |
| October 05, 2026 | November 05, 2026 * | Not Applicable | March 2027 | May 2027 | July 2027 |
| February 05, 2027 | March 05, 2027 * | Not Applicable | July 2027 | October 2027 | December 2027 |
| June 05, 2027 | July 05, 2027 * | Not Applicable | November 2027 | January 2028 | April 2028 |
| October 05, 2027 | November 05, 2027 * | Not Applicable | March 2028 | May 2028 | July 2028 |
Projects funded under PAR-25-281
NIH RePORTER lists 1 project funded under PAR-25-281 in FY2022–FY2026, with $796K in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.
Projects funded
1
Distinct projects, FY2022–FY2026
New awards
1
Type 1 (new project) award records
NIH funding
$796K
Award dollars under PAR-25-281, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 0 | 0 | $0 |
| FY2026 | 1 | 1 | $796K |
Institutions with the most funding
- Michigan State University$796K · 1 project
Funding institutes
- NIMH$796K · 1
Activity codes funded
- R011 record
Most recent new awards
- Gene x Ovarian Hormone Interactions in Perimenopausal Risk for Psychosis (opens NIH RePORTER)
Michigan State University · 1R01MH140527-01A1 · NIMH · Notice Sep 10, 2026
$796KR01
What its predecessor PAR-23-097 funded
PAR-25-281 reissues PAR-23-097. Its funding history is the best guide to who wins under this program: 4 projects and $8.1M in FY2022–FY2026.
Projects funded
4
Distinct projects, FY2022–FY2026
New awards
4
Type 1 (new project) award records
NIH funding
$8.1M
Award dollars under PAR-23-097, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 2 | 2 | $1.7M |
| FY2025 | 3 | 1 | $2.6M |
| FY2026 | 4 | 1 | $3.8M |
Institutions with the most funding
- Icahn School of Medicine at Mount Sinai$2.8M · 1 project
- University of California, San Diego$2.3M · 1 project
- Van Andel Research Institute$1.7M · 1 project
- SRI International$1.3M · 1 project
Funding institutes
- NIMH$8.1M · 9
Activity codes funded
- R019 records
Most recent new awards
- Targeting Insomnia to Prevent Depression in the Menopause Transition (opens NIH RePORTER)
SRI International · 1R01MH141537-01 · NIMH · Notice Sep 17, 2026
$1.3MR01
- The immunobiological mechanisms of depression in perimenopause (opens NIH RePORTER)
Van Andel Research Institute · 1R01MH139201-01 · NIMH · Notice Dec 20, 2024
$919KR01
- Hormonal Drivers of Perimenopausal Inflammation and Mood Symptoms (opens NIH RePORTER)
Icahn School of Medicine at Mount Sinai · 1R01MH135079-01A1 · NIMH · Notice Aug 26, 2024
$910KR01
- Chronobiological Basis of Depression during the Menopause Transition (opens NIH RePORTER)
University of California, San Diego · 1R01MH134120-01A1 · NIMH · Notice May 9, 2024
$777KR01
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
2 NIH institutes and offices take applications under PAR-25-281. Contact the program officer at the institute that fits your research before applying.
- NIMH · National Institute of Mental Health
- ORWH
Related notices
Mar 31, 2025 · NOT-OD-24-084
This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Notices of Special Interest (NOSIs)
NIH has attached 1 NOSI to PAR-25-281; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.
Award terms
- Application types allowed
- NewRenewalResubmissionRevision Renewal of RFA-MH-21-105 and PAR-22-035, PAR-23-097, and PAR-25-282Resubmission of RFA-MH-21-105 , PAR-22-035, PAR-23-097, and PAR-25-282Revision of RFA-MH-21-105 and PAR-22-035, PAR-23-097, and PAR-25-282 The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed…
- Award budget
- Application budgets are not limited but need to reflect the actual needs of the proposed project.
- Project period
- The scope of the proposed project should determine the project period. The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAR-23-097.
- Companion NOFOs: PAR-25-282.
Other open NOFOs for R01
- PAR-25-283Innovative Mental Health Services Research Not Involving Clinical Trials (R01 Clinical Trials Not Allowed)NIMH · next due Feb 5, 2027
- PAR-25-289Navigator Emergency Department Diversion Models for Non-Urgent Mental Health Concerns (R01 Clinical Trial Required)NIMH · next due Feb 5, 2027
- PAR-25-290Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R01 Clinical Trial Optional)NIMH · next due Feb 5, 2027
- PAR-25-287Neuromodulation/Neurostimulation Device Development for Mental Health Applications (R01 Clinical Trial Not Allowed)NIMH · next due Feb 5, 2027
- PAR-25-136Laboratories to Optimize Digital Health (R01 Clinical Trial Required)NIMH · next due Feb 5, 2027
- PAR-25-206Pilot Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required)NIMH · next due Feb 5, 2027
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.