NIH PAR · NIMH · R01
PAR-25-206: Pilot Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
NIMH seeks applications for pilot effectiveness projects to evaluate the preliminary effectiveness of therapeutic and service delivery interventions for the post-acute management of mental health conditions that are matched to the stage of illness in terms of both their focus (e.g., consolidating and maintaining gains from initial treatment, managing residual symptoms/impairment, preventing relapse, promoting adherence and appropriate service use) and intensity/burden. In this pilot phase of effectiveness research, the trial should be designed to evaluate the feasibility, tolerability, acceptability, safety, and potential effectiveness of the approach; to address whether the intervention…
- NOFO number
- PAR-25-206
- Type
- PAR
- Activity code
- R01
- Primary institute
- NIMH · National Institute of Mental Health
- Clinical trials
- Required
- Posted
- Oct 31, 2024
- Opens
- Jan 5, 2025
- Expires
- Jan 8, 2028
PAR-25-206 due dates
3 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Application Due Date(s) | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| February 05, 2025 | March 05, 2025 * | Not Applicable | July 2025 | October 2025 | December 2025 |
| June 05, 2025 | July 05, 2025 * | Not Applicable | November 2025 | January 2026 | April 2026 |
| October 05, 2025 | November 05, 2025 * | Not Applicable | March 2026 | May 2026 | July 2026 |
| February 05, 2026 | March 05, 2026 * | Not Applicable | July 2026 | October 2026 | December 2026 |
| June 05, 2026 | July 05, 2026 * | Not Applicable | November 2026 | January 2027 | April 2027 |
| October 05, 2026 | November 05, 2026 * | Not Applicable | March 2027 | May 2027 | July 2027 |
| February 05, 2027 | March 05, 2027 * | Not Applicable | July 2027 | October 2027 | December 2027 |
| June 05, 2027 | July 05, 2027 * | Not Applicable | November 2027 | January 2028 | April 2028 |
| October 05, 2027 | November 05, 2027 * | Not Applicable | March 2028 | May 2028 | July 2028 |
What its predecessor PAR-21-211 funded
PAR-25-206 reissues PAR-21-211. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 3 projects and $1.6M in FY2022–FY2026.
Projects funded
3
Distinct projects, FY2022–FY2026
New awards
3
Type 1 (new project) award records
NIH funding
$1.6M
Award dollars under PAR-21-211, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 1 | 1 | $158K |
| FY2024 | 2 | 1 | $510K |
| FY2025 | 2 | 0 | $433K |
| FY2026 | 3 | 1 | $462K |
Institutions with the most funding
- Ohio State University$667K · 1 project
- University of Michigan at Ann Arbor$667K · 1 project
- New York State Psychiatric Institute DBA Research Foundation for Mental Hygiene, Inc$228K · 1 project
Funding institutes
- NIMH$1.6M · 8
Activity codes funded
- R348 records
Most recent new awards
- Recovery and Inclusion through Supported Employment for People Experiencing Psychosis in Low Resource Settings (RISE) (opens NIH RePORTER)
New York State Psychiatric Institute DBA Research Foundation for Mental Hygiene, Inc · 1R34MH141628-01 · NIMH · Notice Apr 27, 2026
$163KR34
- Facilitating effective coping to reduce suicide risk following ED discharge: A micro-randomized trial to develop an adaptive text-based intervention (opens NIH RePORTER)
University of Michigan at Ann Arbor · 1R34MH133057-01A1 · NIMH · Notice Mar 20, 2024
$234KR34
- Optimizing residential treatment gains for adolescents through tailored behavioral parent training (opens NIH RePORTER)
Ohio State University · 1R34MH126008-01A1 · NIMH · Notice Nov 30, 2022
$158KR34
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
2 NIH institutes and offices take applications under PAR-25-206. Contact the program officer at the institute that fits your research before applying.
- NIMH · National Institute of Mental Health
- none
Related notices
Mar 31, 2025 · NOT-OD-24-084
This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Notices of Special Interest (NOSIs)
NIH has attached 1 NOSI to PAR-25-206; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.
Award terms
- Application types allowed
- NewResubmissionRevision Resubmission from PAR-21-211, and PAR-25-206Revision from PAR-17-271, PAR-18-431,PAR-21-211, and PAR-25-206 The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Direct costs are limited to 750,000 over the R01 project period, with no more than 250,000 in direct costs allowed in any single year.
- Project period
- The total project period for an application submitted in response to this funding opportunity may not exceed three years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAR-21-211.
- Companion NOFOs: PAR-25-207.
Other open NOFOs for R01
- PAR-25-283Innovative Mental Health Services Research Not Involving Clinical Trials (R01 Clinical Trials Not Allowed)NIMH · next due Feb 5, 2027
- PAR-25-289Navigator Emergency Department Diversion Models for Non-Urgent Mental Health Concerns (R01 Clinical Trial Required)NIMH · next due Feb 5, 2027
- PAR-25-281Mood and Psychosis Symptoms during the Menopause Transition (R01 Clinical Trial Optional)NIMH · next due Feb 5, 2027
- PAR-25-290Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R01 Clinical Trial Optional)NIMH · next due Feb 5, 2027
- PAR-25-287Neuromodulation/Neurostimulation Device Development for Mental Health Applications (R01 Clinical Trial Not Allowed)NIMH · next due Feb 5, 2027
- PAR-25-136Laboratories to Optimize Digital Health (R01 Clinical Trial Required)NIMH · next due Feb 5, 2027
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.