NIH PAR · NIMH · R01
PAR-25-207: Effectiveness Trials for Post-Acute Interventions and Services to Optimize Longer-term Outcomes (R01 Clinical Trial Required)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
NIMH seeks applications for research projects to evaluate the effectiveness of therapeutic and service delivery interventions for the post-acute management of mental health conditions affecting youth, adults, and older adults. This Notice of Funding Opportunity (NOFO) encourages clinical trials to establish the effectiveness and test hypotheses regarding moderators, mediators, and mechanisms of action of post-acute phase therapeutic and services interventions that are matched to the stage of illness in terms of both their focus (e.g., consolidating and maintaining gains from initial treatment, managing residual symptoms/impairment, preventing relapse, promoting adherence and appropriate…
- NOFO number
- PAR-25-207
- Type
- PAR
- Activity code
- R01
- Primary institute
- NIMH · National Institute of Mental Health
- Clinical trials
- Required
- Posted
- Oct 31, 2024
- Opens
- Jan 5, 2025
- Expires
- Jan 8, 2028
PAR-25-207 due dates
3 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Application Due Date(s) | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| February 05, 2025 | March 05, 2025 * | Not Applicable | July 2025 | October 2025 | December 2025 |
| June 05, 2025 | July 05, 2025 * | Not Applicable | November 2025 | January 2026 | April 2026 |
| October 05, 2025 | November 05, 2025 * | Not Applicable | March 2026 | May 2026 | July 2026 |
| February 05, 2026 | March 05, 2026 * | Not Applicable | July 2026 | October 2026 | December 2026 |
| June 05, 2026 | July 05, 2026 * | Not Applicable | November 2026 | January 2027 | April 2027 |
| October 05, 2026 | November 05, 2026 * | Not Applicable | March 2027 | May 2027 | July 2027 |
| February 05, 2027 | March 05, 2027 * | Not Applicable | July 2027 | October 2027 | December 2027 |
| June 05, 2027 | July 05, 2027 * | Not Applicable | November 2027 | January 2028 | April 2028 |
| October 05, 2027 | November 05, 2027 * | Not Applicable | March 2028 | May 2028 | July 2028 |
What its predecessor PAR-21-210 funded
PAR-25-207 reissues PAR-21-210. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 3 projects and $7.4M in FY2022–FY2026.
Projects funded
3
Distinct projects, FY2022–FY2026
New awards
3
Type 1 (new project) award records
NIH funding
$7.4M
Award dollars under PAR-21-210, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 1 | 1 | $771K |
| FY2023 | 1 | 0 | $726K |
| FY2024 | 2 | 1 | $1.5M |
| FY2025 | 3 | 1 | $2.2M |
| FY2026 | 3 | 0 | $2.1M |
Institutions with the most funding
- Butler Hospital (Providence, Ri)$3.6M · 1 project
- University of Michigan at Ann Arbor$2.2M · 1 project
- Massachusetts General Hospital$1.5M · 1 project
Funding institutes
- NIMH$7.4M · 10
Activity codes funded
- R0110 records
Most recent new awards
- Multimodality Adaptive Intervention for Post-Inpatient Hospitalization Suicide Risk Reduction (opens NIH RePORTER)
Massachusetts General Hospital · 1R01MH139522-01 · NIMH · Notice Aug 30, 2025
$854KR01
- Effectiveness of text-based support for parents of suicidal adolescents following emergency department visits (opens NIH RePORTER)
University of Michigan at Ann Arbor · 1R01MH137012-01 · NIMH · Notice Jul 26, 2024
$788KR01
- Effectiveness of a multi-component mHealth intervention to improve post-hospital transitions of care for patients with SMI (opens NIH RePORTER)
Butler Hospital (Providence, Ri) · 1R01MH130496-01 · NIMH · Notice Aug 31, 2022
$771KR01
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
2 NIH institutes and offices take applications under PAR-25-207. Contact the program officer at the institute that fits your research before applying.
- NIMH · National Institute of Mental Health
- none
Related notices
Mar 31, 2025 · NOT-OD-24-084
This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Notices of Special Interest (NOSIs)
NIH has attached 1 NOSI to PAR-25-207; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.
Award terms
- Application types allowed
- NewRenewal Resubmission from PAR-21-210 and PAR-25-207Revision from PAR-17-272, PAR-18-430, PAR-21-210, and PAR-25-207 The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets are not limited but need to reflect the actual needs of the proposed project.
- Project period
- Scope of the proposed project should determine the project period. The maximum period is 5 years; however, most awards will be for 3-4 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAR-21-210.
- Companion NOFOs: PAR-25-206.
Other open NOFOs for R01
- PAR-25-283Innovative Mental Health Services Research Not Involving Clinical Trials (R01 Clinical Trials Not Allowed)NIMH · next due Feb 5, 2027
- PAR-25-289Navigator Emergency Department Diversion Models for Non-Urgent Mental Health Concerns (R01 Clinical Trial Required)NIMH · next due Feb 5, 2027
- PAR-25-281Mood and Psychosis Symptoms during the Menopause Transition (R01 Clinical Trial Optional)NIMH · next due Feb 5, 2027
- PAR-25-290Utilizing Invasive Recording and Stimulating Opportunities in Humans to Advance Neural Circuitry Understanding of Mental Health Disorders (R01 Clinical Trial Optional)NIMH · next due Feb 5, 2027
- PAR-25-287Neuromodulation/Neurostimulation Device Development for Mental Health Applications (R01 Clinical Trial Not Allowed)NIMH · next due Feb 5, 2027
- PAR-25-136Laboratories to Optimize Digital Health (R01 Clinical Trial Required)NIMH · next due Feb 5, 2027
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.