NIH PAR · NIAAA · R61, R33

PAR-25-158: Prevention and Intervention Approaches for Fetal Alcohol Spectrum Disorders (R61/R33 Clinical Trial Optional)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Oct 19, 2026Expires Nov 18, 2026

This Notice of Funding Opportunity (NOFO) focuses on prevention and intervention strategies for fetal alcohol spectrum disorders (FASD) throughout the lifespan. The intent of this NOFO is to support research that advances (1) prevention approaches to reduce prenatal alcohol exposure and the incidence of FASD and that (2) interventions for FASD. These objectives will be accomplished with the Exploratory/Developmental Phased Award (R61/R33) mechanism, clinical trial optional. The R61 phase will support pilot studies or secondary data analysis for hypothesis development and feasibility, and research testing the hypotheses can be expanded in the R33 phase. The transition to the R33 phase will…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-158
Type
PAR
Activity code
R61R33
Primary institute
NIAAA · National Institute on Alcohol Abuse and Alcoholism
Clinical trials
Optional
Posted
Nov 25, 2024
Opens
Jan 19, 2025
Expires
Nov 18, 2026

PAR-25-158 due dates

1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-158
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
February 19, 2025March 18, 2025Not ApplicableJuly 2025October 2025December 2025
June 17, 2025July 17, 2025Not ApplicableNovember 2025January 2026April 2026
October 17, 2025November 18, 2025Not ApplicableMarch 2026May 2026July 2026
February 18, 2026March 17, 2026Not ApplicableJuly 2026October 2026December 2026
June 17, 2026July 17, 2026Not ApplicableNovember 2026January 2027April 2027
October 19, 2026November 17, 2026Not ApplicableMarch 2027May 2027July 2027

Projects funded under PAR-25-158

NIH RePORTER lists 3 projects funded under PAR-25-158 in FY2022–FY2026, with $1.1M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

3

Distinct projects, FY2022–FY2026

New awards

3

Type 1 (new project) award records

NIH funding

$1.1M

Award dollars under PAR-25-158, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-158
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY202633$1.1M

Institutions with the most funding

  1. Henry Ford Health + Michigan State University Health Sciences$510K · 1 project
  2. Yale University$295K · 1 project
  3. University of Florida$283K · 1 project

Funding institutes

  • NIAAA$1.1M · 3

Activity codes funded

  • R613 records

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under PAR-25-158. Contact the program officer at the institute that fits your research before applying.

  • NIAAA · National Institute on Alcohol Abuse and Alcoholism
  • none

Related notices

  1. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  2. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  3. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Notices of Special Interest (NOSIs)

NIH has attached 4 NOSIs to PAR-25-158; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.

Award terms

Application types allowed
NewResubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
For the R61 phase, the combined budget for direct costs during the two-year project period may not exceed 350,000 with no more than 225,000 requested in a single year. For the R33 phase, the direct costs must not exceed 500,000 per year.
Project period
The project period is limited to 2 years for the R61 phase and up to 3 years for the R33 phase. The total project period may not exceed 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PAR-24-068.
  • Companion NOFOs: PAR-25-159.

Other open NOFOs for R61, R33

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

NIH grant searchLook up awards by topic, PI, or institution.Find funded PIsInvestigators with recent NIH awards in your research area.Institute fit by topicWhich NIH institutes and institutions lead a research area.Funding trendsYear-by-year NIH award totals for any keyword.