NIH RFA · NIAID · R61, R33
RFA-AI-27-018: Implementation Science to Advance HIV Prevention, Treatment, and Care (R61/R33 Clinical Trial Optional)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The purpose of this notice of funding opportunity (NOFO) is to support implementation research on strategies to improve the uptake, implementation, sustainment, scale and/or spread of evidence-based prevention, treatment, and care interventions in communities in the U.S. significantly impacted by HIV. Projects should be large in scale with high potential for research and public health impact. Specifically, large single site studies, multi-site studies, and comparative studies are encouraged as scientifically appropriate.
- NOFO number
- RFA-AI-27-018
- Type
- RFA
- Activity code
- R61R33
- Primary institute
- NIAID · National Institute of Allergy and Infectious Diseases
- Clinical trials
- Optional
- Posted
- Oct 6, 2026
- Opens
- Oct 10, 2026
- Expires
- Jun 21, 2029
RFA-AI-27-018 due dates
6 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| November 10, 2026 | November 10, 2026 | Not Applicable | March 2027 | May 2027 | July 2027 |
| June 21, 2027 | June 21, 2027 | Not Applicable | November 2027 | January 2028 | March 2028 |
| October 20, 2027 | October 20, 2027 | Not Applicable | March 2028 | May 2028 | July 2028 |
| June 20, 2028 | June 20, 2028 | Not Applicable | November 2028 | January 2029 | March 2029 |
| October 20, 2028 | October 20, 2028 | Not Applicable | March 2029 | May 2029 | July 2029 |
| June 20, 2029 | June 20, 2029 | Not Applicable | November 2029 | January 2030 | March 2030 |
Funded projects
NIH RePORTER lists no awards under RFA-AI-27-018 in FY2022–FY2026, and it is a new NOFO rather than a reissue. Awards usually appear a few months after the first review cycle.
Participating institutes
18 NIH institutes and offices take applications under RFA-AI-27-018. Contact the program officer at the institute that fits your research before applying.
- NIAID · National Institute of Allergy and Infectious Diseases
- OAR
- NHLBI · National Heart, Lung, and Blood Institute
- NIA · National Institute on Aging
- NIAAA · National Institute on Alcohol Abuse and Alcoholism
- NIAMS · National Institute of Arthritis and Musculoskeletal and Skin Diseases
- NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NIDCR · National Institute of Dental and Craniofacial Research
- NIDDK · National Institute of Diabetes and Digestive and Kidney Diseases
- NIDA · National Institute on Drug Abuse
- NIMH · National Institute of Mental Health
- NINR · National Institute of Nursing Research
- NIMHD · National Institute on Minority Health and Health Disparities
- NLM · National Library of Medicine
- NCI · National Cancer Institute
- ODP
- OBSSR
- ORWH
Related notices
Oct 6, 2026 · NOT-AI-26-004
Notice of Informational Webinar for RFA-AI-27-018, Implementation Science to Advance HIV Prevention, Treatment, and Care R61/R33 Clinical Trial Optional).
Award terms
- Application types allowed
- New Resubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets for the R61 phase are limited to 750,000 direct costs per year, and must reflect the actual needs of the proposed activities. Application budgets for the R33 phase are not limited but need to reflect the actual needs of the proposed project.
- Project period
- The scope of the proposed project should determine the project period. Applicants may request up to two years for the R61 phase and up to four years for the R33 phase. The maximum project period for an application submitted in response to this NOFO cannot exceed five years total. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and…
- Funds available and number of awards
- The following NIH components intend to commit the following amounts in FY 2027:NIAID, 20,000,000, 16-18 awards OAR, 1,000,000, 1-3 awardsNCI, 750,000, 1-2 awards NHLBI, 3,465,000, 3-4 awards NIA, 1,000,000, 1-2 awards NIAAA, 2,000,000, 1-2 awards NIAMS, 1,000,000, 2-4 awards NICHD, 3,000,000, 3-4 awards NIDCR, 1,500,000, 1-2 awards NIDDK, 2,000,000, 1-2 awards NIDA, 2,000,000, 1-2 awards NIMH,…
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Other open NOFOs for R61, R33
- RFA-AI-28-024Accelerating Research and Development of Next Generation Vaccines against Malaria - a Model for Mosquito-Borne Diseases (R61/R33 Clinical Trial Not Allowed)NIAID · next due Feb 11, 2027
- RFA-HL-26-017Catalyze: Product Definition for Small Molecules, Biologics and Combination Products - Target Identification and Validation, and Preliminary Product/Lead Series Identification (R61/R33 Clinical Trials Not Allowed)NHLBI · next due Oct 21, 2026
- RFA-HL-26-018Catalyze: Product Definition for Small Molecules, Biologics, and Combination Products - Preliminary Product/Lead Series Identification and Combination Product Prototype (R33 - Clinical Trial Not Allowed)NHLBI · next due Oct 21, 2026
- PAR-25-158Prevention and Intervention Approaches for Fetal Alcohol Spectrum Disorders (R61/R33 Clinical Trial Optional)NIAAA · next due Oct 19, 2026
- PAR-25-269NCCIH Natural Product Early Phase Clinical Trial Phased Innovation Award (R61/R33 Clinical Trial Required)NCCIH · next due Oct 20, 2026
- PAR-25-270NCCIH Natural Product Early Phase Clinical Trial Award (R33 Clinical Trial Required)NCCIH · next due Oct 20, 2026
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.