NIH PAR · NIDA · R34

PAR-25-100: Pilot Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders (R34 Clinical Trial Optional)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Oct 16, 2026Expires May 8, 2027

This Notice of Funding Opportunity (NOFO) encourages pilot and preliminary research in preparation for larger-scale services research effectiveness trials. Relevant trials may test a wide range of approaches, including interventions, practices, and policies designed to optimize access to, and the quality, effectiveness, affordability and utilization of drug, tobacco, or alcohol use disorder treatments and related services, as well as services for comorbid medical and mental disorder conditions. Relevant approaches may include both those that are novel, and those that are commonly used in practice but lack an evidence base. This NOFO provides resources for assessing the feasibility,…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-100
Type
PAR
Activity code
R34
Primary institute
NIDA · National Institute on Drug Abuse
Clinical trials
Optional
Posted
Dec 6, 2024
Opens
Jan 16, 2025
Expires
May 8, 2027

PAR-25-100 due dates

2 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-100
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
February 16, 2025March 16, 2025 *May 07, 2025 *July 2025October 2025December 2025
June 16, 2025July 16, 2025 *September 07, 2025 *November 2025January 2026April 2026
October 16, 2025November 16, 2025 *January 07, 2026 *March 2026May 2026July 2026
February 16, 2026March 16, 2026 *May 07, 2026 *July 2026October 2026December 2026
June 16, 2026July 16, 2026 *Not ApplicableNovember 2026January 2027April 2027
October 16, 2026November 16, 2026 *Not ApplicableMarch 2027May 2027July 2027
February 16, 2027March 16, 2027 *Not ApplicableJuly 2027October 2027December 2027

Projects funded under PAR-25-100

NIH RePORTER lists 4 projects funded under PAR-25-100 in FY2022–FY2026, with $1.5M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

4

Distinct projects, FY2022–FY2026

New awards

4

Type 1 (new project) award records

NIH funding

$1.5M

Award dollars under PAR-25-100, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-100
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY202644$1.5M

Institutions with the most funding

  1. University of Southern California$751K · 1 project
  2. Boston Medical Center$296K · 1 project
  3. University of California-Irvine$236K · 1 project
  4. Emory University$211K · 1 project

Funding institutes

  • NIDA$1.5M · 4

Activity codes funded

  • R344 records

Most recent new awards

What its predecessor PA-21-180 funded

PAR-25-100 reissues PA-21-180. Its funding history is the best guide to who wins under this program: 14 projects and $9.4M in FY2022–FY2026.

Projects funded

14

Distinct projects, FY2022–FY2026

New awards

14

Type 1 (new project) award records

NIH funding

$9.4M

Award dollars under PA-21-180, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PA-21-180
Fiscal yearAward recordsNew awardsFunding
FY202233$817K
FY2023118$3.4M
FY2024112$2.5M
FY202590$2.0M
FY202631$702K

Institutions with the most funding

  1. University of Washington$1.4M · 2 projects
  2. Boston Medical Center$801K · 1 project
  3. Johns Hopkins University$737K · 1 project
  4. University of Colorado Denver$727K · 1 project
  5. Rhode Island Hospital$723K · 1 project
  6. Baystate Medical Center, Inc.$720K · 1 project
  7. Ohio University Athens$714K · 1 project
  8. Trustees of Indiana University$713K · 1 project

Funding institutes

  • NIDA$8.8M · 36
  • NIAAA$671K · 1

Activity codes funded

  • R3437 records

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under PAR-25-100. Contact the program officer at the institute that fits your research before applying.

  • NIDA · National Institute on Drug Abuse
  • none

Related notices

  1. Jun 3, 2025 · NOT-DA-25-039

    Notice of Change to PAR-25-100, Pilot Health Services and Economic Research on the Treatment of Drug, Alcohol, and Tobacco Use Disorders R34 Clinical Trial Optional)".

  2. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  3. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  4. Aug 5, 2022

    Implementation Details for the NIH Data Management and Sharing Policy.

Notices of Special Interest (NOSIs)

NIH has attached 11 NOSIs to PAR-25-100; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.

Award terms

Application types allowed
NewResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Direct costs are limited to 450,000 over the 3-year project period, with no more than 225,000 in direct costs allowed in any single year.
Project period
The total project period for an application submitted may not exceed three years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PA-21-180.

Other open NOFOs for R34

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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