NIH RFA · NCCIH · R15
RFA-AT-25-003: HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The purpose of this initiative is to: (1) support the efforts by R15-eligible Principal Investigators (PIs) to conduct rigorous basic and/or mechanistic pain research projects; (2) promote integrated, interdisciplinary research partnerships between R15-eligible PIs and additional investigators from U.S. domestic institutions, and (3) enhance the pain research environment at the R15-eligible institution for health professional trainees or undergraduate and/or graduate students by actively engaging them in the proposed pain research projects.
- NOFO number
- RFA-AT-25-003
- Type
- RFA
- Activity code
- R15
- Primary institute
- NCCIH · National Center for Complementary and Integrative Health
- Clinical trials
- Optional
- Posted
- Jan 8, 2025
- Opens
- Sep 29, 2025
- Expires
- Nov 24, 2026
RFA-AT-25-003 due dates
1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Application Due Date(s) | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| October 28, 2025 | October 28, 2025 | November 24, 2025 | March 2026 | May 2026 | July 2026 |
| October 27, 2026 | October 27, 2026 | Not Applicable | March 2027 | May 2027 | July 2027 |
Projects funded under RFA-AT-25-003
NIH RePORTER lists 2 projects funded under RFA-AT-25-003 in FY2022–FY2026, with $1.2M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.
Projects funded
2
Distinct projects, FY2022–FY2026
New awards
2
Type 1 (new project) award records
NIH funding
$1.2M
Award dollars under RFA-AT-25-003, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 0 | 0 | $0 |
| FY2026 | 2 | 2 | $1.2M |
Institutions with the most funding
- Virginia College of Osteopathic Medicine$592K · 1 project
- Fairleigh Dickinson University$560K · 1 project
Funding institutes
- NCCIH$1.2M · 2
Activity codes funded
- R152 records
Most recent new awards
- Investigating back pain injury mechanisms associated with chronic pain behaviors (opens NIH RePORTER)
Virginia College of Osteopathic Medicine · 1R15AT013514-01A1 · NCCIH · Notice Sep 17, 2026
$592KR15
- Phenotyping and Validating Central Sensitization in Painful and Non-Painful Benign Urologic Disease Using Machine Learning (opens NIH RePORTER)
Fairleigh Dickinson University · 1R15AT014052-01 · NCCIH · Notice Aug 18, 2026
$560KR15
What its predecessor RFA-AT-25-001 funded
RFA-AT-25-003 reissues RFA-AT-25-001. Its funding history is the best guide to who wins under this program: 1 project and $540K in FY2022–FY2026.
Projects funded
1
Distinct projects, FY2022–FY2026
New awards
1
Type 1 (new project) award records
NIH funding
$540K
Award dollars under RFA-AT-25-001, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 1 | 1 | $540K |
| FY2026 | 0 | 0 | $0 |
Institutions with the most funding
- Middlebury College$540K · 1 project
Funding institutes
- NCCIH$540K · 1
Activity codes funded
- R151 record
Most recent new awards
- Modeling mechanisms of interindividual variation in pain modulation by spinal cord stimulation (opens NIH RePORTER)
Middlebury College · 1R15AT013512-01 · NCCIH · Notice Aug 15, 2025
$540KR15
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
7 NIH institutes and offices take applications under RFA-AT-25-003. Contact the program officer at the institute that fits your research before applying.
- NCCIH · National Center for Complementary and Integrative Health
- NIA · National Institute on Aging
- NIAAA · National Institute on Alcohol Abuse and Alcoholism
- NIAMS · National Institute of Arthritis and Musculoskeletal and Skin Diseases
- NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NIDCR · National Institute of Dental and Craniofacial Research
- NINDS · National Institute of Neurological Disorders and Stroke
Related notices
Mar 31, 2025 · NOT-OD-24-084
This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Award terms
- Application types allowed
- NewResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Applicants may request up to 375,000 in direct costs for the entire project period. No more than one third of total project costs may go to non-R15-eligible institutions. Annual inflationary increases are not allowed.
- Project period
- The scope of the proposed project should determine the project period. The maximum project period is 3 years.  NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The NIH HEAL Initiative intends to commit an estimated total of 1.25 million to fund up to three awards per year for FY 2026 and FY 2027. Support for this funding opportunity is contingent upon annual NIH appropriations and the submission of a sufficient number of meritorious applications
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of RFA-AT-25-001.
Other open NOFOs for R15
- PAR-25-298Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed)NIDCR · next due Oct 25, 2026
- PAR-25-134Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed)NIGMS · next due Oct 25, 2026
- PAR-27-078Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Required)NIA · next due Oct 25, 2026
- PAR-25-148Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required)NICHD · next due Oct 25, 2026
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.