NIH PAR · NIDCR · R15
PAR-25-298: Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Not Allowed)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The purpose of the Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools is to stimulate basic and clinical research in educational institutions that provide baccalaureate or advanced degrees for a significant number of the Nation's research scientists, but that have not been major recipients of NIH support. REAP grants create opportunities for scientists and institutions otherwise unlikely to participate extensively in NIH research programs to contribute to the Nation's biomedical and behavioral research effort. REAP grants are intended to support small-scale research projects proposed by faculty members of eligible, domestic institutions, to expose…
- NOFO number
- PAR-25-298
- Type
- PAR
- Activity code
- R15
- Primary institute
- NIDCR · National Institute of Dental and Craniofacial Research
- Clinical trials
- Not Allowed
- Posted
- Dec 6, 2024
- Opens
- Jan 8, 2025
- Expires
- Jan 8, 2028
PAR-25-298 due dates
4 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Application Due Date(s) | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| February 25, 2025 | February 25, 2025 * | May 07, 2025 * | July 2025 | October 2025 | December 2025 |
| June 25, 2025 | June 25, 2025 * | September 07, 2025 * | November 2025 | January 2026 | April 2026 |
| October 25, 2025 | October 25, 2025 * | January 07, 2026 * | March 2026 | May 2026 | July 2026 |
| February 25, 2026 | February 25, 2026 * | May 07, 2026 * | July 2026 | October 2026 | December 2026 |
| June 25, 2026 | June 25, 2026 * | Not Applicable | November 2026 | January 2027 | April 2027 |
| October 25, 2026 | October 25, 2026 * | Not Applicable | March 2027 | May 2027 | July 2027 |
| February 25, 2027 | February 25, 2027 * | Not Applicable | July 2027 | October 2027 | December 2027 |
| June 25, 2027 | June 25, 2027 * | Not Applicable | November 2027 | January 2028 | April 2028 |
| October 25, 2027 | October 25, 2027 * | Not Applicable | March 2028 | May 2028 | July 2028 |
Projects funded under PAR-25-298
NIH RePORTER lists 29 projects funded under PAR-25-298 in FY2022–FY2026, with $15.9M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.
Projects funded
29
Distinct projects, FY2022–FY2026
New awards
27
Type 1 (new project) award records
NIH funding
$15.9M
Award dollars under PAR-25-298, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 0 | 0 | $0 |
| FY2026 | 29 | 27 | $15.9M |
Institutions with the most funding
- East Tennessee State University$1.7M · 3 projects
- Baylor University$1.6M · 3 projects
- Midwestern University (Glendale Az)$1.6M · 3 projects
- New York Inst of Technology$1.1M · 2 projects
- Mercer University Macon$1.1M · 2 projects
- Rowan University$1.1M · 2 projects
- Mgh Institute of Health Professions$624K · 1 project
- Texas Tech University$588K · 1 project
Funding institutes
- NHLBI$3.9M · 7
- NIAID$3.9M · 7
- NCI$1.6M · 3
- NICHD$1.6M · 3
- NIAMS$1.5M · 3
- NIA$1.2M · 2
- NINDS$1.1M · 2
- NIMH$559K · 1
Activity codes funded
- R1529 records
Most recent new awards
- Mechanotransduction from the tumor microenvironment to the nuclear envelope protein emerin enables nuclear softening during cancer metastasis (opens NIH RePORTER)
Rowan University · 1R15CA309616-01A1 · NCI · Notice Sep 23, 2026
$564KR15
- Identifying the molecular differences between oncogenic BMI1 and its tumor suppressive paralog, MEL18 (opens NIH RePORTER)
Midwestern University (Glendale Az) · 1R15CA317831-01 · NCI · Notice Sep 17, 2026
$527KR15
- Impact of sulfated glycans on HSV-1 mediated entry and inflammation in iris stroma derived from human eye donors (opens NIH RePORTER)
Midwestern University · 1R15AI202615-01 · NIAID · Notice Sep 8, 2026
$559KR15
- Identifying the Spinal Molecular Mechanisms of Chronic Pain Induced by Systemic Lupus Erythematosus (opens NIH RePORTER)
Northern California Health Services and Research Foundation · 1R15AR087723-01 · NIAMS · Notice Sep 7, 2026
$413KR15
- Improving the Assessment of Great Toe Function and its Association with Gait and Balance in Older Adults (opens NIH RePORTER)
California State University San Marcos · 1R15AG098615-01A1 · NIA · Notice Sep 4, 2026
$541KR15
- Mobile Media Use and Preschoolers’ Peer Interaction Skills (opens NIH RePORTER)
Baylor University · 1R15HD122735-01 · NICHD · Notice Sep 2, 2026
$520KR15
What its predecessor PAR-22-060 funded
PAR-25-298 reissues PAR-22-060. Its funding history is the best guide to who wins under this program: 75 projects and $32.9M in FY2022–FY2026.
Projects funded
75
Distinct projects, FY2022–FY2026
New awards
66
Type 1 (new project) award records
NIH funding
$32.9M
Award dollars under PAR-22-060, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 1 | 1 | $447K |
| FY2023 | 30 | 27 | $13.2M |
| FY2024 | 29 | 26 | $12.6M |
| FY2025 | 15 | 12 | $6.7M |
| FY2026 | 0 | 0 | $0 |
Institutions with the most funding
- New York Inst of Technology$2.7M · 6 projects
- Duquesne University$2.1M · 5 projects
- Rowan University$2.0M · 4 projects
- Auburn University at Auburn$1.8M · 4 projects
- Southern Illinois University Carbondale$1.3M · 3 projects
- Western University of Health Sciences$1.3M · 3 projects
- Chapman University$1.2M · 3 projects
- St. John's University$984K · 2 projects
Funding institutes
- NCI$9.3M · 21
- NHLBI$4.8M · 11
- NINDS$4.0M · 9
- NICHD$3.0M · 7
- NIA$2.7M · 6
- NIEHS$2.2M · 5
- NIAID$1.3M · 3
- NIMH$1.3M · 3
Activity codes funded
- R1575 records
Most recent new awards
- Dissecting the Role of Lrh1 in Phthalate-Related Reproductive Impairments: A Cellular and Molecular Approach (opens NIH RePORTER)
Midwestern University (Glendale Az) · 1R15ES037124-01A1 · NIEHS · Notice Aug 28, 2025
$522KR15
- The role of orosomucoid1 in skeletal muscle aging during an optimized autophagy activity intervention (opens NIH RePORTER)
Rowan University · 1R15AG095821-01 · NIA · Notice Aug 12, 2025
$530KR15
- Mechanistic studies on the role of GABA type A ion channel (GABAA) receptors in triple negative breast cancer (opens NIH RePORTER)
Saint Joseph's University · 1R15CA301412-01 · NCI · Notice Aug 12, 2025
$421KR15
- Deciphering novel UPS regulation of Sgf73/ataxin-7 in controlling SAGA and associated functions in gene expression (opens NIH RePORTER)
Southern Illinois University Carbondale · 1R15CA290595-01A1 · NCI · Notice Aug 8, 2025
$446KR15
- RgIA5474 as a Novel α9α10 Nicotinic Acetylcholine Receptor Antagonist to Treat Migraine (opens NIH RePORTER)
New York Inst of Technology · 1R15NS143081-01 · NINDS · Notice Jul 22, 2025
$473KR15
- Anatomy and Physiology of Molecular Layer Heterotopia (opens NIH RePORTER)
New York Inst of Technology · 1R15NS137226-01A1 · NINDS · Notice Jul 11, 2025
$459KR15
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
19 NIH institutes and offices take applications under PAR-25-298. Contact the program officer at the institute that fits your research before applying.
- NIDCR · National Institute of Dental and Craniofacial Research
- NEI · National Eye Institute
- NHLBI · National Heart, Lung, and Blood Institute
- NHGRI · National Human Genome Research Institute
- NIA · National Institute on Aging
- NIAAA · National Institute on Alcohol Abuse and Alcoholism
- NIAID · National Institute of Allergy and Infectious Diseases
- NIAMS · National Institute of Arthritis and Musculoskeletal and Skin Diseases
- NIBIB · National Institute of Biomedical Imaging and Bioengineering
- NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NIDCD · National Institute on Deafness and Other Communication Disorders
- NIDA · National Institute on Drug Abuse
- NIEHS · National Institute of Environmental Health Sciences
- NIMH · National Institute of Mental Health
- NINDS · National Institute of Neurological Disorders and Stroke
- NINR · National Institute of Nursing Research
- NCCIH · National Center for Complementary and Integrative Health
- ORIP
- NCI · National Cancer Institute
Related notices
Jan 28, 2026 · NOT-OD-26-029
NIH Removing AIDS Application Due Dates from NOFOs. See Notice NOT-OD-26-029.
Mar 31, 2025 · NOT-OD-24-084
This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Notices of Special Interest (NOSIs)
NIH has attached 21 NOSIs to PAR-25-298; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.
Award terms
- Application types allowed
- NewRenewalResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Applicants may request up to 375,000 in direct costs, excluding consortium F&A, for the entire project period of up to 3 years.
- Project period
- The scope of the proposed project should determine the project period.  The maximum project period is 3 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAR-22-060.
- Companion NOFOs: PAR-25-134, PAR-25-148.
Other open NOFOs for R15
- PAR-25-134Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Not Allowed)NIGMS · next due Oct 25, 2026
- RFA-AT-25-003HEAL Initiative: Pain Research Enhancement Program (PREP) (R15 Clinical Trial Optional)NCCIH · next due Oct 27, 2026
- PAR-27-078Research Enhancement Award Program (REAP) for Health Professional Schools and Graduate Schools (R15 Clinical Trial Required)NIA · next due Oct 25, 2026
- PAR-25-148Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions (R15 Clinical Trial Required)NICHD · next due Oct 25, 2026
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.