NIH R15 Grants — AREA / REAP Award

Recent R15 awards from NIH RePORTER

Examples of funded R15 projects across the last two fiscal years. The matching-award count comes from the full result set; funding totals, averages, rankings, and examples use the first 500 records returned by NIH RePORTER. Figures reflect a snapshot last refreshed on September 5, 2026.

Example R15 projects from the sample

• Mechanistic studies of Metal Ion-Induced Transthyretin Misfolding and Toxic Oligomer Formation

  3R15GM163276-01S1
  KWANG HUN LIM · EAST CAROLINA UNIVERSITY, NC · $29,677 · awarded Aug 27, 2026 · NIH

  Misfolding and aggregation of transthyretin (TTR) is implicated in numerous degenerative diseases, including cardiomyopathy and polyneuropathy (ATTR amyloidosis). Protein misfolding involves structural changes from native polypeptides to oligomeric intermediate states, which eventually form cross-β structured amyloid fibrils. Understanding the molecular…

• Rapid Vertical Flow Immunoassay Capable of Advancing Point of Care Diagnostics by Amplifying Underutilized Signals via Site-Specific Assembly of Antibody and Augmented Plasmonic Coupling

  1R15EB039339-01
  Jun-Hyun Kim · ILLINOIS STATE UNIVERSITY, IL · $553,931 · awarded Aug 21, 2026 · NIH

  PROJECT SUMMARY Improvements in infectious disease prevention and management may be achieved through better diagnostics. Point-of-care (POC) diagnostic tests are poised to make the greatest impact, yet despite substantial effort, current approaches suffer from limited analytical sensitivity resulting in poor diagnostic accuracy. The long-term goal of this…

• Single-cell function, morphology, and transcriptome study of lobule selective cerebellar Purkinje cell degeneration in SMA

  2R15NS120154-02
  Jianli Sun · DELAWARE STATE UNIVERSITY, DE · $517,862 · awarded Aug 21, 2026 · NIH

  PROJECT SUMMARY/ABSTRACT This proposal is a renewal of our current R15 which was awarded by NINDS in February 2022. The award number is: 1R15NS120154-01A1. The project title is: The neuropathology of cerebellum in spinal muscular atrophy. The budget period is: 03/01/2022 – 02/28/2025. Spinal muscular atrophy (SMA) is a neuromuscular disorder resulting from…

• Maintenance of male fertility via RNA binding proteins

  1R15HD123283-01
  KELLEE SIEGFRIED · UNIVERSITY OF MASSACHUSETTS BOSTON, MA · $577,974 · awarded Aug 20, 2026 · NIH

  Project Summary Infertility affects over 17% of couples and in about half of these cases the male partner contributes to the inability to conceive. Continuous sperm production is dependent on the regulation of spermatogenesis, including proliferation and differentiation of spermatogonial stem cells (SSCs). The regulation of SSCs is controlled by a complex…

• A randomized, double-blinded, controlled clinical trial to assess the impact of dietary flaxseed on heart health and allostatic load in young adults

  1R15HL181699-01A1
  Stephanie Caligiuri · COLLEGE OF WILLIAM AND MARY, VA · $585,016 · awarded Aug 18, 2026 · NIH

  PROJECT SUMMARY Chronic stress and malnutrition are increasingly recognized as major, synergistic contributors to early cardiometabolic disease, particularly among young adults. College students represent a vulnerable population, facing high academic, social, and financial demands with limited access to preventive health care. Our recent data from over 100…

• Phenotyping and Validating Central Sensitization in Painful and Non-Painful Benign Urologic Disease Using Machine Learning

  1R15AT014052-01
  Benjamin Johnson · FAIRLEIGH DICKINSON UNIVERSITY, NJ · $560,491 · awarded Aug 18, 2026 · NIH

  Interstitial cystitis/bladder pain syndrome (IC/BPS) and overactive bladder (OAB) are prevalent, debilitating urologic disorders marked by lower urinary tract symptoms—including pain, urgency, and frequency—but lack mechanistically informed treatments. Evidence implicates central sensitization (CS)—heightened central nervous system responsiveness—in…

• Non-Pharmacological Therapies vs. Prescription Drug Therapy for Care of Aged Medicare Beneficiaries with Spinal Pain

  1R15AT013300-01A1
  Steffany Moonaz · SOUTHERN CALIFORNIA UNIV OF HEALTH SCIS, CA · $535,524 · awarded Aug 18, 2026 · NIH

  PROJECT SUMMARY Spinal Pain (SP) is highly prevalent, costly, and a leading cause of disability, but the management of SP in the United States tends to be inefficient, costly, and sometimes hazardous. Thus, there is an acute need to identify safe, high-quality management strategies for patients with SP. Because SP is often persistent, many patients feel…

• Merging Sound and Light: Dual-Mode Ultrasound/NIR Fluorescence Imaging with Metal-Doped Graphene Quantum Dots

  1R15EB038729-01
  Anton Naumov · TEXAS CHRISTIAN UNIVERSITY, TX · $495,541 · awarded Aug 18, 2026 · NIH

  Project Summary/Abstract Dual-mode imaging is an emerging frontier in biomedical diagnostics offering complementary advantages of detecting and tracing targets inaccessible to single imaging techniques. In this proposal we develop novel dule-mode contrast agents aiming to combine the anatomical visualization of ultrasound imaging (USI) with the high…

• Toward the Prevention of Depression Among Neurodivergent College Students

  1R15MH141564-01A1
  Steven Brunwasser · ROWAN UNIVERSITY, NJ · $562,666 · awarded Aug 17, 2026 · NIH

  PROJECT SUMMARY/ABSTRACT Depression on college campuses carries a substantial public health burden, with symptoms particularly high, and satisfaction with mental health services particularly low among neurodivergent students (NDS). This proposal aims to lay the foundation for sustainable community-informed preventive care tailored to NDS making the…

• Spatial navigation as a domain-specific marker of cognitive decline in Down Syndrome

  1R15HD121055-01
  Yingying Yang · MONTCLAIR STATE UNIVERSITY, NJ · $547,500 · awarded Aug 17, 2026 · NIH

  Project Summary Adults with Down syndrome (DS) face a disproportionately high risk for Alzheimer’s disease (AD), creating an urgent need for earlier detection and timely support. In neurotypical populations, spatial navigation deficits have emerged as sensitive and early markers of cognitive decline (e.g., in mild cognitive impairment [MCI] and AD).…

• Defining the Role of Varicose Projection Astrocytes in Alzheimer's Disease Pathology

  1R15AG101508-01
  Carmen Falcone · TOWSON UNIVERSITY, MD · $471,303 · awarded Aug 14, 2026 · NIH

  PROJECT SUMMARY Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that remains without effective treatment. Mounting evidence suggests that neuroinflammation plays a critical role in AD progression, yet the contribution of astrocytes—a major glial cell type involved in brain homeostasis—remains poorly defined. Recent discoveries from our…

• Examining the role of insula sub-circuits in attention-guided behavior

  1R15MH144559-01
  HENRY HALLOCK · LAFAYETTE COLLEGE, PA · $490,855 · awarded Aug 14, 2026 · NIH

  PROJECT SUMMARY Deficits in attention are a common cognitive symptom across a range of neuropsychiatric and neurodegenerative disorders, including attention-deficit hyperactivity disorder (ADHD), major depressive disorder (MDD), schizophrenia, and Alzheimer’s disease (AD). The most commonly used test to assess attention deficits in these patient populations…

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