NIH Grant Search by PI — Funded Principal Investigator Finder

Search NIH grants by PI name or research area. Look up funded principal investigators, see their NIH RePORTER awards, institutions, and project details.

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Enter a research topic, disease, or technology to find principal investigators with NIH funding in that area. To look up a specific PI by name, use the PI Funding Status check.

Search Results

Found 200 principal investigators from 200 displayed projects for "R15" (2021–2026)

Note: 244 projects matched but only the first 200 were analyzed. Try narrowing your search with a more specific term or selecting "Project title only".

Opportunity Digest

Heuristic scoring to help trainees and job seekers prioritize which labs to inspect first.

0

High-opportunity leads

4

Likely hiring signals

1

Training-friendly awards

17

Average opportunity score

Prioritize records with strong opportunity signals, then validate fit using abstracts, institution pages, and lab websites.

Filter for opportunity type

Lauren M. Anllo

EAST CAROLINA UNIVERSITY, GREENVILLE, NC

Good lead · 56/100
Likely hiring
Very recent
Active award
$168,918
FY 2026

Project Title

Mechanisms that establish a functional stem cell niche during organogenesis

Grant Number:

1R35GM162435-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract: Stem cells are required for tissue homeostasis and regeneration. Accomplishing these tasks requires intimate association with a niche, a cellular microenvironment that forms in a specialized tissue location with precise morphology to enable communication with stem cells. Ni...

Research Terms

<21+ years old><Ablation><Adult><Adult Human><Aging><Anterior><Architecture><Assay><Autoregulation><Basal Transcription Factor><Basal transcription factor genes><Behavior><Bioassay><Biological><Biological Assay><Body Tissues><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cellular Matrix><Communication><Cues><Cytoskeletal System><Cytoskeleton><Data><Development><Drosophila><Drosophila genus><Embryo Development><Embryogenesis><Embryonic Development><Engineering / Architecture><F-Actin><Filamentous Actin><Funding><Gene Expression><General Transcription Factor Gene><General Transcription Factors><Genetic><Genetic Models><Gonadal structure><Homeostasis><Image><Injury><Intracellular Communication and Signaling><Laser Electromagnetic><Laser Radiation><Lasers><Location><Maintenance><Mechanics><Methods><Modeling><Morphogenesis><Morphology><Movement><Muscle><Muscle Tissue><Natural regeneration><Organogenesis><Ortholog><Orthologous Gene><Physiological Homeostasis><Population><Position><Positioning Attribute><Progenitor Cells><Protocol><Protocols documentation><Regeneration><Signal Transduction><Signal Transduction Systems><Signaling><Specific qualifier value><Specified><System><Testicles><Testing><Testis><Tissues><Transcription Factor Proto-Oncogene><Transcription factor genes><Visceral><Visualization><Work><adulthood><biologic><biological signal transduction><body movement><cell behavior><cellular behavior><developmental><driving force><fruit fly><gonad><gonads><image-based method><imaging><imaging in vivo><imaging method><imaging modality><in vivo><in vivo imaging><injuries><intracellular skeleton><islet><mechanic><mechanical><migration><morphogenetic process><muscular><novel><optogenetics><progenitor cell niche><progenitor niche><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><response><stem and progenitor cell niche><stem cell niche><stem cells><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><transcription factor><unpublished works>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Lichuan Ye

NORTHEASTERN UNIVERSITY, BOSTON, MA

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$594,677
FY 2025

Project Title

OurSleepKit: A Couple-focused mHealth Tool to Support Adherence to CPAP Treatment

Grant Number:

5R01HL160836-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/5/2022

End Date:

1/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Poor adherence to continuous positive airway pressure (CPAP) treatment remains the single largest impediment to effective management for obstructive sleep apnea (OSA) leading to increased morbidity, mortality, and higher health care costs. Existing interventions promoting CPAP adher...

Research Terms

<Address><Adherence><Adopted><Affect><Age><CPAP><CPAP Ventilation><Caring><Characteristics><Clinic><Clinical Trials><Continuous Positive Airway Pressure><Control Groups><Couples><Data><Development><Diagnosis><Disease><Disorder><Drowsiness><Emotional><Evaluation><Exposure to><Family><Frequencies><Gender><Goals><Health><Health Benefit><Health Care Costs><Health Care Professional><Health Costs><Health Professional><Individual><Intervention><Interview><Life><Link><Maintenance><Measures><Modeling><Morbidity><Morbidity - disease rate><Newly Diagnosed><Notification><Obstructive Sleep Apnea><Patients><Periodicals><Play><Preparation><Problem Solving><Process><QOL><Qualitative Methods><Quality of life><Race><Races><Randomized><Role><Secure><Self Efficacy><Self Management><Sleep><Sleep disturbances><Snoring><Somnolence><Standardization><Subgroup><Syndrome, Sleep Apnea, Obstructive><Technology><Testing><Treatment outcome><Update><Work><aberrant sleep><ages><assess effectiveness><care partner><caregiving partner><coping><demographics><determine effectiveness><developmental><disrupted sleep><disturbed sleep><effective therapy><effective treatment><effectiveness assessment><effectiveness evaluation><efficacy outcomes><evaluate effectiveness><examine effectiveness><experience><field based data><field learning><field study><field test><group intervention><handheld mobile device><health economics><impaired sleep><improved><innovate><innovation><innovative><irregular sleep><m-Health><mHealth><mHealth therapeutic><mHealth therapy><mHealth treatment><mhealth interventions><mobile device><mobile health><mobile health intervention><mobile health therapeutic><mobile health therapy><mobile health treatment><mortality><periodic><periodical><pilot test><preparations><promoter><promotor><prototype><qualitative reasoning><quality of sleep><racial><racial background><racial origin><randomisation><randomization><randomly assigned><secondary outcome><sleep disruption><sleep dysregulation><sleep quality><sleep/wake disruption><sleep/wake disturbance><sleepiness><social><social role><socio-economic><socio-economically><socioeconomically><socioeconomics><success><therapy optimization><tool><treatment adherence><treatment compliance><treatment optimization>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

SHOHEI KOIDE

MEDICAL UNIVERSITY OF SOUTH CAROLINA, CHARLESTON, SC

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$588,746
FY 2025

Project Title

Probing RAS-mediated Signaling with Monobody Inhibitors

Grant Number:

5R01CA212608-10

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2017

End Date:

7/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Cancer is a leading cause of death in the United States and worldwide. This innovative multi-PI project in its 6th year has established a novel approach to the challenge of discovering strategies to control cancer. Oncogenic activation of the RAS family of GTPases occurs in ~30% of c...

Research Terms

<Address><Affect><Affinity><Alleles><Allelomorphs><Amino Acids><Antibodies><Architecture><Artificial Genes><Award><Binding><Binding Proteins><Biochemical><Biochemistry><Biological Agent><Biological Chemistry><Biological Products><Biological Testing><Biology><C-K-RAS><Cancer Control><Cancer Control Science><Cancer Genes><Cancer Patient><Cancer Treatment><Cancer-Promoting Gene><Cancers><Cause of Death><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Colorectal Cancer><Communities><Complex><DNA mutation><Data><Development><Dimerization><Disulfides><Drugs><Engineering><Engineering / Architecture><FDA approved><Family><Family member><Funding><GDP Dissociation Factor><GDP Dissociation Stimulators><GDP Exchange Factors><GDP-GTP Exchange Protein><GDP-GTP Reversing Factors><GTP><GTP Binding><GTP GDP exchange factor><GTP Phosphohydrolases><GTP bound><GTPases><Genetic><Genetic Change><Genetic defect><Genetic mutation><Guanine><Guanine Nucleotide Exchange Factors><Guanine Nucleotide Exchange Protein><Guanine Nucleotide Releasing Factors><Guanine Nucleotides><Guanosine Phosphates><Guanosine Triphosphate><Guanosine Triphosphate Phosphohydrolases><Guanosinetriphosphatases><Guanyl-Nucleotide Exchange Factor><Guanyl-Nucleotide Releasing Factor><H-ras><H-ras Gene><H-ras Oncogene><HRAS><HRAS gene><HRAS1><Harvey Rat Sarcoma Viral Oncogene Homolog><Heterozygote><Human><Intracellular Communication and Signaling><Investigators><Isoforms><K-RAS2A><K-RAS2B><K-Ras><K-Ras 2A><K-Ras-2 Oncogene><KRAS><KRAS2><KRAS2 gene><Ki-RAS><Laboratories><Ligand Binding Protein><Ligand Binding Protein Gene><Lobe><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Pancreatic Neoplasm><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Malignant neoplasm of pancreas><Mediating><Medication><Modern Man><Molecular><Molecular Interaction><Mutate><Mutation><Nucleotides><Oncogene K-Ras><Oncogenes><Oncogenesis><Oncogenic><Pancreas Cancer><Pancreatic Cancer><Pharmaceutical Preparations><Phase><Process><Productivity><Protein Binding><Protein Dimerization><Protein Engineering><Protein Isoforms><Proteins><Pulmonary Cancer><Pulmonary malignant Neoplasm><RAS genes><RAS inhibition><RASH1><RASK2><Ras Inhibitor><Reagent><Research Personnel><Researchers><Role><Series><Signal Transduction><Signal Transduction Systems><Signaling><Site><Specificity><Synthetic Genes><System><Technology><Therapeutic><Transforming Genes><Ubiquitin Ligase Component Gene><Ubiquitin Ligase Gene><United States><Work><aminoacid><anti-cancer research><anti-cancer therapy><biological signal transduction><biologics><biopharmaceutical><biotherapeutic agent><bound protein><cancer research><cancer therapy><cancer-directed therapy><developmental><drug/agent><empowerment><established cell line><exchange factor><genetic protein engineering><genome mutation><guanosinetriphosphatase><heterozygosity><in vivo><inhibitor><innovate><innovation><innovative><insight><lobes><lung cancer><malignancy><mouse model><murine model><mutant><nano><nanocluster><neoplasm/cancer><new approaches><novel><novel approaches><novel strategies><novel strategy><pancreatic malignancy><pharmacologic><pharmacophore><prevent><preventing><protein design><recruit><small molecular inhibitor><small molecule inhibitor><social role><success><therapeutic agent development><therapeutic development><therapeutic target><therapeutically effective><tool><tumor addiction><tumorigenesis><ubiquitin ligase><v-Ha-RAS Harvey Rat Sarcoma Viral Oncogene Homolog><v-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

John P O'Bryan

MEDICAL UNIVERSITY OF SOUTH CAROLINA, CHARLESTON, SC

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$588,746
FY 2025

Project Title

Probing RAS-mediated Signaling with Monobody Inhibitors

Grant Number:

5R01CA212608-10

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2017

End Date:

7/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Cancer is a leading cause of death in the United States and worldwide. This innovative multi-PI project in its 6th year has established a novel approach to the challenge of discovering strategies to control cancer. Oncogenic activation of the RAS family of GTPases occurs in ~30% of c...

Research Terms

<Address><Affect><Affinity><Alleles><Allelomorphs><Amino Acids><Antibodies><Architecture><Artificial Genes><Award><Binding><Binding Proteins><Biochemical><Biochemistry><Biological Agent><Biological Chemistry><Biological Products><Biological Testing><Biology><C-K-RAS><Cancer Control><Cancer Control Science><Cancer Genes><Cancer Patient><Cancer Treatment><Cancer-Promoting Gene><Cancers><Cause of Death><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Colorectal Cancer><Communities><Complex><DNA mutation><Data><Development><Dimerization><Disulfides><Drugs><Engineering><Engineering / Architecture><FDA approved><Family><Family member><Funding><GDP Dissociation Factor><GDP Dissociation Stimulators><GDP Exchange Factors><GDP-GTP Exchange Protein><GDP-GTP Reversing Factors><GTP><GTP Binding><GTP GDP exchange factor><GTP Phosphohydrolases><GTP bound><GTPases><Genetic><Genetic Change><Genetic defect><Genetic mutation><Guanine><Guanine Nucleotide Exchange Factors><Guanine Nucleotide Exchange Protein><Guanine Nucleotide Releasing Factors><Guanine Nucleotides><Guanosine Phosphates><Guanosine Triphosphate><Guanosine Triphosphate Phosphohydrolases><Guanosinetriphosphatases><Guanyl-Nucleotide Exchange Factor><Guanyl-Nucleotide Releasing Factor><H-ras><H-ras Gene><H-ras Oncogene><HRAS><HRAS gene><HRAS1><Harvey Rat Sarcoma Viral Oncogene Homolog><Heterozygote><Human><Intracellular Communication and Signaling><Investigators><Isoforms><K-RAS2A><K-RAS2B><K-Ras><K-Ras 2A><K-Ras-2 Oncogene><KRAS><KRAS2><KRAS2 gene><Ki-RAS><Laboratories><Ligand Binding Protein><Ligand Binding Protein Gene><Lobe><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Pancreatic Neoplasm><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Malignant neoplasm of pancreas><Mediating><Medication><Modern Man><Molecular><Molecular Interaction><Mutate><Mutation><Nucleotides><Oncogene K-Ras><Oncogenes><Oncogenesis><Oncogenic><Pancreas Cancer><Pancreatic Cancer><Pharmaceutical Preparations><Phase><Process><Productivity><Protein Binding><Protein Dimerization><Protein Engineering><Protein Isoforms><Proteins><Pulmonary Cancer><Pulmonary malignant Neoplasm><RAS genes><RAS inhibition><RASH1><RASK2><Ras Inhibitor><Reagent><Research Personnel><Researchers><Role><Series><Signal Transduction><Signal Transduction Systems><Signaling><Site><Specificity><Synthetic Genes><System><Technology><Therapeutic><Transforming Genes><Ubiquitin Ligase Component Gene><Ubiquitin Ligase Gene><United States><Work><aminoacid><anti-cancer research><anti-cancer therapy><biological signal transduction><biologics><biopharmaceutical><biotherapeutic agent><bound protein><cancer research><cancer therapy><cancer-directed therapy><developmental><drug/agent><empowerment><established cell line><exchange factor><genetic protein engineering><genome mutation><guanosinetriphosphatase><heterozygosity><in vivo><inhibitor><innovate><innovation><innovative><insight><lobes><lung cancer><malignancy><mouse model><murine model><mutant><nano><nanocluster><neoplasm/cancer><new approaches><novel><novel approaches><novel strategies><novel strategy><pancreatic malignancy><pharmacologic><pharmacophore><prevent><preventing><protein design><recruit><small molecular inhibitor><small molecule inhibitor><social role><success><therapeutic agent development><therapeutic development><therapeutic target><therapeutically effective><tool><tumor addiction><tumorigenesis><ubiquitin ligase><v-Ha-RAS Harvey Rat Sarcoma Viral Oncogene Homolog><v-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Priscila Falagan Lotsch

AUBURN UNIVERSITY AT AUBURN, Auburn, AL

Good lead · 48/100
Above-average budget
Very recent
Active award
$571,566
FY 2026

Project Title

Unraveling the Biological Effects of Engineered Nanomaterials from a Mitochondrial Perspective

Grant Number:

1R15ES038685-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/20/2026

End Date:

4/19/2029

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Despite their widespread presence in our modern life, the biological effects of engineered nanomaterials (ENMs) under exposure conditions that more accurately reflect real-world human experiences (low doses over extended periods) remain poorly understood. Our preliminary data...

Research Terms

<AD patients><Acute><Address><Affect><Air Pollutants><Alzheimer's disease patient><Alzheimer's patient><Assay><Autoregulation><Benefits and Risks><Bioassay><Biogenesis><Biological><Biological Assay><Cancers><Cardiovascular Diseases><Cell Body><Cell Death><Cell Function><Cell Line><Cell Physiology><Cell Process><CellLine><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular biology><Characteristics><Chemicals><Chemistry><Chronic><Chronic Disease><Chronic Illness><Data><Decision Making><Degenerative Neurologic Disorders><Dermal><Development><Disease><Disorder><Dose><Enzyme Gene><Enzymes><Evaluation><Experimental Designs><Fibroblasts><Fostering><Future><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Goals><Health><Heavy Metals><Homeostasis><Human><In Vitro><Intuition><Knowledge><Life><Link><Malignant Neoplasms><Malignant Tumor><Measures><Membrane Potentials><Metabolic><Mitochondria><Modality><Modeling><Modern Man><Modernization><Molecular><Molecular Toxicology><Morphology><NIH><Nanotechnology><National Institutes of Health><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Origin of Life><Outcome><Oxidation-Reduction><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Pathway interactions><Physiologic><Physiological><Physiological Homeostasis><Physiology><Play><Process><Property><Public Health><Redox><Research><Respiration><Resting Potentials><Role><Safety><Shapes><Strains Cell Lines><Stress><Structure><Subcellular Process><System><Testing><Therapeutic><Therapeutic Agents><Toxic effect><Toxicities><Training><Transcript Expression Analyses><Transcript Expression Analysis><Transmembrane Potentials><United States National Institutes of Health><Universities><Work><analyze gene expression><anti-oxidant enzyme><antioxidant enzyme><biologic><cardiovascular disorder><cell biology><chronic disorder><cultured cell line><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><design><designing><developmental><disease model><disorder model><enzyme activity><experience><gene expression analysis><gene expression assay><gold nano particle><gold nanoparticle><graduate student><hands on research><iPS><iPSC><iPSCs><in vitro Model><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><insight><interest><intuitive><malignancy><mitochondrial><mitochondrial dysfunction><mitochondrial membrane><nano><nano engineering><nano gold><nano particle><nano tech><nano technology><nano-sized particle><nano-technological><nanoGold><nanoengineering><nanomaterials><nanoparticle><nanosized particle><nanotech><nanotechnological><necrocytosis><neoplasm/cancer><neurodegenerative illness><oxidation reduction reaction><pathway><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><programs><public trust><respiratory mechanism><social role><transcriptional profiling><undergrad><undergraduate><undergraduate research experience><undergraduate research opportunities><undergraduate research programs><undergraduate student>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Michael P. Guy

NORTHERN KENTUCKY UNIVERSITY, HIGHLAND HEIGHTS, KY

Good lead · 48/100
Above-average budget
Very recent
Active award
$525,000
FY 2026

Project Title

Determining how tRNA modifications affect translation in multiple eukaryotes

Grant Number:

2R15GM128050-03

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2018

End Date:

4/30/2029

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Translation is a key step in the process that cells use to convert genetic information into proteins, and defects in translation are linked to many human diseases. A critical component of translation is transfer RNA (tRNA), which must be extensively chemically modified by cellular enzymes f...

Research Terms

<Adult-Onset Diabetes Mellitus><Affect><Anticodon><Assay><Award><Baker's Yeast><Binding><Bioassay><Biochemical><Biochemistry><Bioinformatics><Biological><Biological Assay><Biological Chemistry><Biomedical Research><Brewer's Yeast><Budding Yeast><CDLIV><Cancers><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Expansion><Cellular Function><Cellular Growth><Cellular Physiology><Cellular Process><Chemicals><Codon><Codon Nucleotides><Complex><DNA Molecular Biology><DNA mutation><Defect><Disease><Disorder><Distant><EC 2.1.1><Endomycetales><Enzyme Gene><Enzymes><Eukaryota><Eukaryote><Exposure to><FTSJ1><Fission Yeast><Funding><GeneHomolog><Generations><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Genome><Genomics><Glycine-Specific tRNA><Grant><Guide RNA><Health><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><Homolog><Homologous Gene><Homologue><Human><Individual><Institution><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Investigators><JM23><Kentucky><Ketosis-Resistant Diabetes Mellitus><Knowledge><Link><MRX44><Malignant Neoplasms><Malignant Tumor><Maturity-Onset Diabetes Mellitus><Messenger RNA><Methylation><Methyltransferase><Modern Man><Modernization><Modification><Molecular><Molecular Biology><Molecular Interaction><Molecular Modeling Nucleic Acid Biochemistry><Molecular Modeling Protein/Amino Acid Biochemistry><Molecular Models><Mutation><NGS Method><NGS system><NIDDM><NIH><National Institutes of Health><Nervous System Diseases><Nervous System Disorder><Neurologic Disorders><Neurological Disorders><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Obesity><Organism><Pathway interactions><Play><Polycystic Ovarian Disease><Polycystic Ovarian Syndrome><Polycystic Ovary Syndrome><Position><Positioning Attribute><Proteins><R-Series Research Projects><R01 Mechanism><R01 Program><RNA Stability><Reporter><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Role><S cerevisiae><S pombe><S. cerevisiae><S. pombe><SPB1><Saccharomyces cerevisiae><Saccharomycetales><Schizosaccharomyces pombe><Science><Sclerocystic Ovarian Degeneration><Sclerocystic Ovary Syndrome><Series><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Stop Codon><Students><Subcellular Process><Suppressor Transfer RNA><System><T2 DM><T2D><T2DM><TRM7><TRMT7><Techniques><Termination Codon><Terminator Codon><Training><Transfer RNA><Translation Stop Signal><Translations><Triplet Codon-Amino Acid Adaptor><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><United States National Institutes of Health><Universities><Variant><Variation><Work><X-linked mental retardation 9><Yeasts><adiposity><adult onset diabetes><biologic><career><cell growth><corpulence><experience><gRNA><genetic information><genome mutation><human disease><insight><intellectual and developmental disability><ketosis resistant diabetes><limited intellectual functioning><living system><mRNA><malignancy><maturity onset diabetes><methylase><model organism><molecular modeling><mutant><neoplasm/cancer><neurological disease><next gen sequencing><next generation sequencing><nextgen sequencing><pathway><polycystic ovary><polycystic ovary disease><polycystic ovary disorder><posttranscriptional><protein complex><social role><tRNA><tRNAGly><transfer Ribonucleic acids><translation><transmethylase><type 2 DM><type II DM><type two diabetes><undergrad><undergraduate><undergraduate student>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

STEVEN FIERING

DARTMOUTH COLLEGE, HANOVER, NH

Exploratory lead · 42/100
Large award
Active award
Team-scale grant
$4,546,782
FY 2025

Project Title

New Hampshire IDeA Network of Biomedical Research Excellence (NH-INBRE)

Grant Number:

2P20GM103506-16

Activity Code:

P20

Mechanism:

Research Centers

Agency:

NIH

Start Date:

9/1/2010

End Date:

5/31/2030

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Abstract This application for renewal of the grant supporting the New Hampshire IDeA Network of Biological Research Excellence (NH-INBRE) proposes to 1) support engagement of PUI-P students in biomedical research to expand research and career development.; 2) increase success obtaining external biom...

Research Terms

<2 year college><Administrator><Agriculture><Belief><Bioinformatics><Bioinformatics core><Bioinformatics research core><Bioinformatics resource core><Biologic Sciences><Biological Sciences><Biology><Biomedical Research><Biometrics><Biometry><Bioscience><Biostatistics><Budgets><COBRE><Center of Biomedical Research Excellence><Centers of Research Excellence><Characteristics><Chemistry><Cloud Computing><Cloud Infrastructure><Collaborations><Compensation><Data><Data Science><Data Science Core><Data Science Resource Core><Development><Development and Research><Education><Educational aspects><Educational process of instructing><Educational workshop><Eligibility><Eligibility Determination><Engineering><Enrollment><Equipment><Evaluation><Faculty><Faculty Education><Faculty Training><Fostering><Foundations><Funding><Goals><Grant><Health><Health Care><Home><Human><Human Resources><Infrastructure><Institution><Investigators><Investments><Laboratory Research><Leadership><Life Sciences><Manpower><Mentors><Modern Man><NIH><National Institutes of Health><New Hampshire><Ownership><P01 Mechanism><P01 Program><Phase><Pilot Projects><Principal Investigator><Process><Productivity><Program Project Grant><Program Research Project Grants><Protocol Screening><Psychology><R & D><R&D><Reproducibility><Research><Research Personnel><Research Program Projects><Research Resources><Research Support><Research Training><Researchers><Resources><Schools><Science><Scientist><Sight><Structure><Students><System><Teacher Education><Teacher Educator><Teacher Preparation><Teacher Professional Development><Teacher Training><Teaching><Time><Training><Training Activity><United States National Institutes of Health><Universities><Vision><Work><Workshop><biological research><career><career development><cloud based computing><cloud computer><college><college student><collegiate><community college><developmental><empowerment><enroll><expectation><faculty development><faculty professional development><higher education><homes><improved><instructor training><junior college><medical college><medical schools><peer><peer coaching><peer instruction><peer led team learning><peer mentoring><peer teaching><personnel><pilot study><primarily undergraduate institution><programs><research and development><school of medicine><student engagement><student mentoring><student motivation><student participation><student research><student-led learning><student-led research><success><support network><teacher development><training module><two year college><undergrad><undergraduate><undergraduate student><university student><visual function>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Carolyn Hovde Bohach

UNIVERSITY OF IDAHO, MOSCOW, ID

Exploratory lead · 42/100
Large award
Active award
Team-scale grant
$3,979,166
FY 2025

Project Title

Idaho INBRE Program

Grant Number:

2P20GM103408-24

Activity Code:

P20

Mechanism:

Research Centers

Agency:

NIH

Start Date:

9/30/2001

End Date:

8/31/2030

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

2P20GM103408-24 9047 Idaho INBRE Developmental Research Project Program (DRPP) Project Summary/Abstract The Developmental Research Project Program (DRPP) will select and support the most promising and meritorious emerging biomedical research in Idaho with emphasis on early stage investigators. The ...

Research Terms

<Abbreviations><Address><Advisory Committees><Appointment><Area><Award><Biomedical Research><Budgets><Collaborations><Committee Members><Communities><Complement><Complement Proteins><Core Facility><Data Science Core><Data Science Resource Core><Development><Doctor of Philosophy><Education><Educational aspects><Educational process of instructing><Eligibility><Eligibility Determination><Ensure><Environment><Equilibrium><Evaluation><Faculty><Feedback><Fostering><Foundations><Funding><Funding Opportunities><Goals><Grant><History><Idaho><Infrastructure><Institution><Interdisciplinary Research><Interdisciplinary Study><Investigators><Investments><Lead><Measures><Medical Education><Mentors><Multidisciplinary Collaboration><Multidisciplinary Research><NIGMS><NIH><National Institute of General Medical Sciences><National Institutes of Health><Outcome><P01 Mechanism><P01 Program><Participant><Pathogenesis><Pb element><Ph.D.><PhD><Pilot Projects><Policies><Process><Productivity><Program Project Grant><Program Research Project Grants><Protocol Screening><Publications><Qualifying><R-Series Research Projects><R01 Mechanism><R01 Program><Recommendation><Recording of previous events><Research><Research Grants><Research Personnel><Research Program Projects><Research Project Grants><Research Projects><Research Resources><Research Support><Researchers><Resource Sharing><Resources><Review Committee><Science><Scientific Publication><Scientist><Secure><Selection Criteria><Site><Students><Talents><Task Forces><Teaching><Training><United States National Institutes of Health><Universities><Washington><Work><advisory team><balance><balance function><career><career development><complementation><developmental><experience><faculty mentor><faculty research><flexibility><flexible><heavy metal Pb><heavy metal lead><high standard><histories><improved><innovate><innovation><innovative><insight><interest><medical college><medical schools><multidisciplinary><novel><pilot study><primarily undergraduate institution><programs><recruit><school of medicine><skills training><student research><student-led research><success><support network><undergrad><undergraduate><undergraduate research><undergraduate student>
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Jose R. Rodriguez-Medina

UNIVERSITY OF PUERTO RICO MED SCIENCES, SAN JUAN, PR

Exploratory lead · 42/100
Large award
Active award
Team-scale grant
$3,824,178
FY 2025

Project Title

Advancing Competitive Biomedical Research in Puerto Rico

Grant Number:

5P20GM103475-23

Activity Code:

P20

Mechanism:

Research Centers

Agency:

NIH

Start Date:

9/15/2001

End Date:

6/30/2027

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

- Overall The overall goal of the Puerto Rico IDeA Network of Biomedical Research Excellence is to augment research capacity in Puerto Rico at the Lead and Network institutions by enhancing the research infrastructure, providing support for meritorious research projects, and providing research exper...

Research Terms

<American><Area><Behavior><Bioinformatics><Bioinformatics core><Bioinformatics research core><Bioinformatics resource core><Biomedical Research><Cancers><Communication><Competence><Development><Development and Research><Discipline><Doctor of Philosophy><Economic Development><Economical Development><Economics><Education><Educational aspects><Educational process of instructing><Educational workshop><Environment><Evaluation><Faculty><Faculty Education><Faculty Training><Financial Support><Flooding><Floods><Funding><Funding Agency><Funding Source><General Population><General Public><Generalized Growth><Goals><Grant><Growth><Health><Human><Hurricane><Infrastructure><Institution><Interdisciplinary Research><Interdisciplinary Study><Investigators><Island><Journals><K-12 student><K12 student><Laboratories><Lead><Magazine><Malignant Neoplasms><Malignant Tumor><Manuscripts><Measures><Medical><Mentors><Methodology><Modern Man><Molecular Medicine><Multidisciplinary Collaboration><Multidisciplinary Research><Neurosciences><Outcome><P01 Mechanism><P01 Program><Palsy><Paralysed><Pb element><Peer Review><Persons><Ph.D.><PhD><Plegia><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Process><Program Project Grant><Program Research Project Grants><Publishing><Puerto Rico><R & D><R&D><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Associate><Research Grants><Research Infrastructure><Research Personnel><Research Program Projects><Research Project Grants><Research Projects><Research Proposals><Research Support><Researchers><Route><Science><Scientist><Staff Development><Students><Teacher Education><Teacher Educator><Teacher Preparation><Teacher Professional Development><Teacher Training><Teaching><Technology><Tissue Growth><Training><Travel><Universities><Work><Workshop><Writing><base><bases><career><developmental><drug development><drug discovery><economic><editorial><experience><faculty development><faculty professional development><financial assistance><fundamental research><graduate student><heavy metal Pb><heavy metal lead><high standard><higher education><human disease><improved><instructor training><instrumentation><local economy><malignancy><metropolitan><neoplasm/cancer><next generation><novel><ontogeny><outreach><paralysis><paralytic><post-doc><post-doctoral><post-doctoral trainee><post-doctoral training><primarily undergraduate institution><programs><research and development><research associates><resilience><resilient><response><teacher><teacher development><tropical cyclone><undergrad><undergraduate><undergraduate research experience><undergraduate research opportunities><undergraduate research programs><undergraduate student>
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Margaret Panning Pearce

ROWAN UNIVERSITY, GLASSBORO, NJ

Exploratory lead · 40/100
Above-average budget
Recent
Active award
$549,717
FY 2026

Project Title

Mechanisms of mutant huntingtin aggregate engulfment and spreading by phagocytic glia

Grant Number:

2R15NS128847-03

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/19/2022

End Date:

11/30/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease (PD), and Huntington’s disease (HD), are rapidly rising in prevalence as our population ages. Despite extensive research, no disease- modifying treatments are currently available to slow or stop progression ...

Research Terms

<21+ years old><AD dementia><Address><Adult><Adult Human><Age><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Amyloid><Amyloid Substance><Appearance><Astrocytes><Astrocytus><Astroglia><Axon><Behavior><Body Tissues><Brain><Brain Nervous System><CNS Nervous System><Cell Body><Cell Communication and Signaling><Cell Culture Techniques><Cell Signaling><Cells><Central Nervous System><Chronic><Communication><Cytoplasm><Data><Defect><Degenerative Neurologic Disorders><Dendrites><Disease><Disorder><Drosophila><Drosophila genus><Eating><Encephalon><Endosomes><Exhibits><Exocytosis><Experimental Models><Flies><Food Intake><GTP Phosphohydrolases><GTPases><Glia><Glial Cells><Goals><Guanosine Triphosphate Phosphohydrolases><Guanosinetriphosphatases><HD Gene><HD protein><Hortega cell><Huntingtin><Huntingtin Protein><Huntington Chorea><Huntington Disease><Huntington gene><Huntington protein><Huntington's><Huntington's Disease><Huntington's disease gene product><Huntingtons Disease><IT15 gene><Immune Surveillance><Immunoblotting><Immunologic Surveillance><Immunosurveillance><In Vitro><Inflammatory><Intracellular Communication and Signaling><Kinases><Knowledge><Kolliker's reticulum><LRRK2><LRRK2 gene><LRRK2 leucine-rich repeat kinase 2 gene><LRRK2 protein><Length><Ligands><Link><Lysosomes><Mediating><Mediator><Membrane><Mice><Mice Mammals><Microglia><Microscopy><Molecular><Monomeric G-Proteins><Monomeric GTP-Binding Proteins><Murine><Mus><N-terminal><NH2-terminal><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neuraxis><Neurites><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neuroglia><Neuroglial Cells><Neurologic Degenerative Conditions><Neuron Degeneration><Neurons><Non-neuronal cell><Nonneuronal cell><Ortholog><Orthologous Gene><PARK8 protein><Paralysis Agitans><Parkinson><Parkinson Disease><Parkinson disease 8 protein><Participant><Pathogenesis><Pathogenicity><Pathologic><Pathology><Pathway interactions><Phagocytes><Phagocytic Cell><Phagocytosis><Phagolysosome><Phagosomes><Phosphorylation><Phosphotransferase Gene><Phosphotransferases><Physiologic><Physiological><Play><Population><Prevalence><Primary Parkinsonism><Primary Senile Degenerative Dementia><Prion Diseases><Prion Protein Diseases><Prion-Induced Disorder><Prions><Process><Property><Protein Phosphorylation><Proteins><Proteomics><Receptosomes><Regulation><Reporting><Research><Risk><Risk Factors><Role><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Small G-Proteins><Small GTPases><Stress><Structure-Activity Relationship><Symptoms><Synapses><Synaptic><System><Testing><Therapeutic Intervention><Tissues><Transmissible Dementias><Transmissible Spongiform Encephalopathies><Transmission><Transphosphorylases><Variant><Variation><Vesicle><Western Blotting><Western Immunoblotting><Work><aberrant folded protein><aberrant folded proteins><aberrant protein folding><abnormal folded protein><abnormal folded proteins><abnormal protein folding><acetyl-LDL receptor><acetylated LDL receptor><adulthood><age associated decline><age dependent decline><age related decline><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><ages><aging population><amebocyte><astrocytic glia><biological signal transduction><cell culture><cell cultures><cell type><chemical structure function><dardarin><dardarin gene><dardarin protein><decline with age><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><druggable target><extracellular><fly><fruit fly><gitter cell><guanosinetriphosphatase><in vivo><injury response><innovate><innovation><innovative><insight><insoluble aggregate><interesting transcript 15><intervention therapy><leucine-rich repeat kinase 2><membrane structure><mesoglia><microglial cell><microgliocyte><misfolded protein><misfolded proteins><mutant><nerve cell death><nerve cell loss><nerve cement><neural degeneration><neural inflammation><neurodegeneration><neurodegenerative><neurodegenerative illness><neuroinflammation><neuroinflammatory><neurological degeneration><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal><neuronal cell death><neuronal cell loss><neuronal death><neuronal degeneration><neuronal loss><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathologic protein folding><pathway><perivascular glial cell><population aging><postsynaptic><premature><prematurity><presynaptic><primary degenerative dementia><prion disorder><prion-like><protein aggregate><protein aggregation><protein blotting><protein misfolding><protein protein interaction><proteotoxic protein><proteotoxin><rab G-Proteins><rab GTP-Binding Proteins><rab GTPases><response><response to injury><scavenger receptor><senile dementia of the Alzheimer type><social role><spongiform degeneration><spongiform encephalopathy><structure function relationship><synapse><therapeutic target><transmission process>
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Isabelle Bichindaritz

COLLEGE AT OSWEGO, OSWEGO, NY

Exploratory lead · 28/100
Above-average budget
Active award
$591,468
FY 2025

Project Title

Explainable Analogical Learning for Oncology Diagnosis and Prediction based on Deep Pathophysiology

Grant Number:

1R15CA297754-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/6/2025

End Date:

7/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

To improve cancer diagnosis, risk stratification, and therapeutics, the National Cancer Institute has called for machine learning (ML) methods to mine this heterogeneous Big Data with efficient and interpretable, but currently unavailable models. Among these, cognitive analogy-based models typically...

Research Terms

<AI based model><AI model><AI system><Adoption><Advanced Cancer><Advanced Malignant Neoplasm><Architecture><Artificial Intelligence><Big Data><BigData><Biological Markers><Cancer Cause><Cancer Detection><Cancer Etiology><Cancers><Caring><Categories><Classification><Clinical><Clinical Decision Support Systems><Cognitive><Complex><Computer Reasoning><Data><Data Bases><Databases><Detection><Development><Diagnosis><Diagnostic><Disease><Disorder><Dysfunction><Effectiveness><Engineering / Architecture><Ensure><Environment><Evolution><Functional disorder><Generations><Genomics><Glass><Goals><Human><Interdisciplinary Research><Interdisciplinary Study><Knowledge><Learning><Machine Intelligence><Machine Learning><Malignant Neoplasms><Malignant Tumor><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Methods><Modeling><Modern Man><Molecular><Multidisciplinary Collaboration><Multidisciplinary Research><NCI Organization><National Cancer Institute><Neoplasm Metastasis><Oncology><Oncology Cancer><Pathway interactions><Patients><Performance><Physiopathology><Predictive Cancer Model><Proteomics><Public Health><Recommendation><Research><Safety><Sampling><Secondary Neoplasm><Secondary Tumor><Severities><Students><Survival Analyses><Survival Analysis><System><Systematics><Technology><Therapeutic><Visualization><artificial intelligence model><artificial intelligence-based model><assess effectiveness><bio-markers><biologic marker><biomarker><biomed informatics><biomedical informatics><cancer care><cancer diagnosis><cancer metastasis><cancer progression><cancer risk><cancer survival><cognitive system><complex data><computer based Semantic Analysis><data base><data integration><deep learning><deep learning method><deep learning strategy><design><designing><determine effectiveness><developmental><effectiveness assessment><effectiveness evaluation><epigenomics><evaluate effectiveness><examine effectiveness><graduate student><high dimensionality><improved><individual patient><individualized cancer therapy><machine based learning><machine learning based method><machine learning based model><machine learning method><machine learning methodologies><machine learning model><machine statistical learning><malignancy><neoplasm progression><neoplasm/cancer><neoplastic progression><new diagnostics><new drug treatments><new drugs><new marker><new pharmacological therapeutic><new therapeutics><new therapy><next generation diagnostics><next generation therapeutics><novel biomarker><novel diagnostics><novel drug treatments><novel drugs><novel marker><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathophysiology><pathway><personalization of treatment><personalized cancer therapy><personalized cancer treatment><personalized medicine><personalized therapy><personalized treatment><petabyte><prevent><preventing><random forest><risk stratification><semantic web><statistical and machine learning><stratify risk><survival prediction><synergism><transcriptomics><translational impact><trustworthiness><tumor cell metastasis><tumor progression><undergrad><undergraduate><undergraduate research experience><undergraduate research opportunities><undergraduate research programs><undergraduate student>
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Robert Arnold Larson

MICHIGAN TECHNOLOGICAL UNIVERSITY, HOUGHTON, MI

Exploratory lead · 28/100
Above-average budget
Active award
$589,998
FY 2025

Project Title

Cardiac Sensory and Sympathetic Nerve Dysregulation in Hypertrophic Cardiomyopathy

Grant Number:

1R15HL177713-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2025

End Date:

8/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Familial hypertrophic cardiomyopathy (HCM) is the most common genetic heart disease with an estimated prevalence of 1:500 individuals in the general population. Sarcomere gene mutations result in the characteristic features of HCM include left ventricular (LV) hypertrophy, myocyte di...

Research Terms

<21+ years old><ASIC channel><Ablation><Academic Research Enhancement Awards><Acceleration><Actin-Activated ATPase><Acute><Adult><Adult Human><Affect><Afferent Neurons><Arrhythmia><Asymmetric Septal Hypertrophy><Biology><Blood Pressure><Cardiac><Cardiac Arrhythmia><Cardiac Diseases><Cardiac Disorders><Cardiac Muscle Cells><Cardiac Myocytes><Cardiac ablation><Cardiac infarction><Cardiocyte><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular Physiology><Cardiovascular system><Catheter Ablation><Cell Communication and Signaling><Cell Signaling><Characteristics><Chronic><DNA mutation><Data><Detection><Development><Disease><Disease Progression><Disorder><Dysfunction><Exercise><Exhibits><Fainting><Familial Asymmetric Septal Hypertrophy><Familial Hypertrophic Cardiomyopathy><Familial Ventricular Hypertrophy><Feedback><Female><Fibrosis><Fibrosis in the heart><Fibrosis in the myocardium><Fibrosis within the heart><Fibrosis within the myocardium><Fibrotic myocardium><Functional disorder><Gene Alteration><Gene Mutation><General Population><General Public><Genetic><Genetic Change><Genetic defect><Genetic mutation><Goals><Health><Heart><Heart Arrhythmias><Heart Diseases><Heart Muscle Cells><Heart Vascular><Heart failure><Heart myocyte><Hereditary ventricular hypertrophy><Human><Hypertrophic Cardiomyopathy><Hypertrophic Obstructive Cardiomyopathy><Idiopathic Hypertrophic Subvalvular Stenosis><Idiopathic hypertrophic subaortic stenosis><Individual><Inflammation><Intracellular Communication and Signaling><Investigation><Ischemia><Knowledge><Left Ventricles><Left Ventricular Function><Left Ventricular Hypertrophy><Left ventricular structure><Levarterenol><Levonorepinephrine><Measures><Mechanics><Mediating><Metabolic><Metabolic dysfunction><Mice><Mice Mammals><Michigan><Mission><Modern Man><Molecular><Murine><Mus><Muscle Cells><Mutation><Myocardial Infarct><Myocardial Infarction><Myocarditis><Myocytes><Myosin ATPase><Myosin Adenosine Triphosphatase><Myosin Adenosinetriphosphatase><Myosins><Nerve><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neuronal Dysfunction><Neurons><Noradrenaline><Norepinephrine><Pathologic><Patients><Phenotype><Physiopathology><Prevalence><R15 Mechanism><R15 Program><Reflex><Reflex action><Regulation><Reporting><Research><Role><Sarcomeres><Sensory><Sensory Neurons><Severity of illness><Signal Transduction><Signal Transduction Systems><Signaling><Spinal><Structure><Sudden Death><Symptoms><Syncope><TRP channel><TRPV1><TRPV1 gene><Techniques><Technology><Testing><Transient receptor potential channel><Universities><Vasodilatation><Vasodilation><Vasorelaxation><abnormal reflex><acid-sensing ion channels><adult youth><adulthood><afferent nerve><alleviate symptom><ameliorating symptom><autonomic nerve><biological signal transduction><cardiac damage><cardiac failure><cardiac fibrosis><cardiac function><cardiac infarct><cardiac inflammation><cardiac innervation><cardiomyocyte><cardiovascular function><circulatory system><congenital hypertrophic cardiomyopathy><coronary attack><coronary fibrosis><coronary infarct><coronary infarction><decrease symptom><developmental><disease severity><falls><fewer symptoms><fibrotic heart><function of the heart><gene defect><genome mutation><heart attack><heart damage><heart disorder><heart fibrosis><heart function><heart infarct><heart infarction><heart innervation><high risk><hypertrophic myocardiopathy><improved><inherited hypertrophic cardiomyopathy><innovate><innovation><innovative><interstitial><male><mechanic><mechanical><mouse model><murine model><mutant allele><myocardial fibrosis><neural><neural dysfunction><neuronal><neuronal NET protein><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><noradrenaline transporter><norepinephrine transporter><norepinephrine transporter protein><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><orthostatic stress><pathophysiology><reduce symptoms><relieves symptoms><sensory nerve><slc6a2 protein><slc6a5 protein><small molecular inhibitor><small molecule><small molecule inhibitor><social role><sodium-dependent noradrenaline transporter><solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2><solute carrier family 6 (neurotransmitter transporter, norepinephrine), member 5><sudden cardiac death><symptom alleviation><symptom reduction><symptom relief><transient receptor potential cation channel V1><undergrad><undergraduate><undergraduate student><young adult><young adult age><young adulthood><α-Tropomyosin><♀><♂>
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HEDEEL I. GUY EVANS

EASTERN MICHIGAN UNIVERSITY, YPSILANTI, MI

Exploratory lead · 28/100
Above-average budget
Active award
$562,500
FY 2025

Project Title

Probing the Role of Insulin-Like Growth Factor-Binding Protein 3 and Humanin in Regulating Hyaluronan Function

Grant Number:

2R15GM131222-03

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2019

End Date:

8/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Glycosaminoglycans (GAGs), components of the highly dynamic extracellular matrix (ECM), play a crucial role in the undertaking of numerous cellular processes and a variety of human diseases result from disruption of their function. Hyaluronan (HA) is a critical component of the ECM a...

Research Terms

<1-Phosphatidylinositol 3-Kinase><2-Amino-2-Deoxyglucose><2-amino-2-deoxy-D-glucose><A β-42><A β42><A-beta 42><A-beta42><A549><Abeta-42><Abeta42><Acetylcholine Hydrolase><Acetylcholinesterase><Adenosine Cyclic Monophosphate-Dependent Protein Kinases><Affect><Alzheimer beta-Protein><Alzheimer's Amyloid beta-Protein><Alzheimer's amyloid><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-42><Amyloid beta-Protein><Amyloid beta42><Amyloid β><Amyloid β-42><Amyloid β-Peptide><Amyloid β-Protein><Amyloid β42><Amyloidβ-42><Amyloidβ42><Antioncogene Protein p53><Apopain><Apoptosis><Apoptosis Pathway><Apoptosis-Related Cysteine Protease Caspase 3><Aβ><Aβ-42><Aβ42><BDNF><Basic Research><Basic Science><Binding><Biological Function><Biological Process><Biomedical Research><Brain-Derived Neurotrophic Factor><CASP-3><CASP3><CASP3 gene><CD44><CD44 Adhesion Receptor><CD44 Antigens><CD44 gene><CD44 molecule><CDDP><CLG4><CLG4A><CLG4B><CPP-32><CPP32><CPP32 protein><CPP32B><CPP32beta><Carbohydrates><Casein Kinase TS><Casein Kinase-2><Causality><Cell Anoxia><Cell Body><Cell Communication and Signaling><Cell Function><Cell Hypoxia><Cell Physiology><Cell Process><Cell Signaling><Cell Survival><Cell Viability><Cell surface><Cell-Extracellular Matrix><Cells><Cellular Anoxia><Cellular Function><Cellular Hypoxia><Cellular Physiology><Cellular Process><Cellular Tumor Antigen P53><Cis-diammine-dichloroplatinum><Cis-diamminedichloridoplatinum><Cis-diamminedichloro Platinum (II)><Cis-dichloroammine Platinum (II)><Cis-platinous Diamine Dichloride><Cis-platinum II><Cis-platinum II Diamine Dichloride><Cisplatin><Cisplatina><Cisplatinum><Complex><Cyclic AMP-Dependent Protein Kinases><Cysplatyna><Cysteine Protease CPP32><Cysteine Protease CPP32 Gene><Data><Development><Dichlorodiammineplatinum><Disaccharides><Disease><Disorder><EC 1.1.1.27><ECM><EGF Receptor><EGFR><ERBB Protein><Education><Educational aspects><Epidermal Growth Factor Receptor><Epidermal Growth Factor Receptor Kinase><Epidermal Growth Factor Receptor Protein-Tyrosine Kinase><Epidermal Growth Factor-Urogastrone Receptors><Etiology><Extracellular Matrix><Fostering><GELB><Glucosamine><Glucuronic Acids><Glycans><Glycolysis><Glycosaminoglycans><Goals><Growth Factor Receptors><H1299><HER1><HPSE Protein><HUTCH-1><Health><Heparan Sulfate><Heparanase-1><Heparitin Sulfate><Hermes Antigen><Human><Hyaluronan><Hyaluronan Receptors><Hyaluronan-Binding Protein><Hyaluronic Acid Binding Protein><Hypoxia><Hypoxic><IGF Type 1 Receptor><IGF-1 Receptor><IGF-Binding Protein 3><IGF-I Receptor><IGFBP-3><Insulin-Like Growth Factor 1 Receptor><Insulin-Like Growth Factor Binding Protein 3><Insulin-Like Growth Factor Type 1 Receptor><Insulin-Like-Growth Factor I Receptor><Intervention><Intracellular Communication and Signaling><Knowledge><L-Lactate Dehydrogenase><L-Lactic Acid Dehydrogenase><Lactate Dehydrogenase><Lead><Link><Lung><Lung Respiratory System><MDU3><MMP2><MMP2 gene><MMP9><MMP9 gene><Metabolic><Mission><Modern Man><Molecular><Molecular Interaction><Mucopolysaccharides><NAD-Lactate Dehydrogenase><NIH><National Institutes of Health><Nerve Transmitter Substances><Neurotransmitters><Nicotine><Nicotinic Acetylcholine Receptors><Nicotinic Receptors><Oncoprotein p53><Outcome><Oxygen Deficiency><P53><PARP Cleavage Protease><PARP Cleavage Protease Gene><PI-3 Kinase><PI3-Kinase><PI3CG><PI3KGamma><PI3k><PIK3><PIK3CG><PIK3CG gene><PKA><Pathway interactions><Pb element><Peptides><Peyrone's Chloride><Peyrone's Salt><Pgp1><Phosphatidylinositol 3-Kinase><Phosphatidylinositol-3-OH Kinase><Phosphoinositide 3-Hydroxykinase><Phosphoprotein P53><Phosphoprotein pp53><Phosphorylation><Platinum Diamminodichloride><Play><Polysaccharides><Process><Production><Programmed Cell Death><Protein Kinase A><Protein Kinase CK2><Protein Kinase CKII><Protein Phosphorylation><Protein TP53><Proteins><PtdIns 3-Kinase><Public Health><Receptor Cell><Receptor Protein><Receptor Signaling><Regulation><Research Training><Resistance><Role><SCA-1><SCA-1 Gene><SREBP Cleavage Activity 1><SREBP Cleavage Activity 1 Gene><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Structure><Students><Subcellular Process><TBE-1><TGF-alpha Receptor><TP53><TP53 gene><TRP53><Testing><Toxic effect><Toxicities><Transforming Growth Factor alpha Receptor><Tumor Protein p53><Tumor Protein p53 Gene><Type I Phosphatidylinositol Kinase><Type III Phosphoinositide 3-Kinase><United States National Institutes of Health><Urogastrone Receptor><Yama><Yama protein><a beta peptide><abeta><abeta accumulation><abeta aggregation><acetylcholine acetylhydrolase><alpha-bungarotoxin binding sites><alpha-bungarotoxin receptor><alpha7 nicotinic acetylcholine receptor><alpha7nAChR><amyloid beta><amyloid beta accumulation><amyloid beta aggregation><amyloid β accumulation><amyloid β aggregation><amyloid-b protein><aβ accumulation><aβ aggregation><beta amyloid fibril><beta-adrenergic receptor><biological signal transduction><brain-derived neurotrophic factor precursor><c-erbB-1><c-erbB-1 Protein><cAMP-Dependent Protein Kinases><career><casein kinase II><caspase-3><causation><cell behavior><cellular behavior><choline esterase I><cis dichlorodiammineplatinum><cis platinum compound><cis-Diaminedichloroplatinum><cis-Diamminedichloroplatinum><cis-Diamminedichloroplatinum(II)><cis-Dichlorodiammineplatinum(II)><cis-Platinum><cysteine protease P32><developmental><disease causation><erbB-1><erbB-1 Proto-Oncogene Protein><erbBl><extracellular><functional outcomes><gp85><graduate student><hands on research><heavy metal Pb><heavy metal lead><heparan sulphate endoglycosidase><heparanase><human disease><humanin><improved><inhibitor><innovate><innovation><innovative><insight><interest><lactic acid dehydrogenase><lung cancer cell><macromolecule><new approaches><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapeutics><new therapy><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><next generation therapeutics><novel><novel approaches><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapeutics><novel therapy><novel therapy approach><novel therapy target><p53 Antigen><p53 Genes><p53 Tumor Suppressor><pathway><pro-BDNF><protein p53><proto-oncogene protein c-erbB-1><public health relevance><receptor><resilience><resilient><resistant><response><social role><soluble amyloid precursor protein><therapeutic target><tool><undergrad><undergraduate><undergraduate student><α7 nicotinic acetylcholine receptor><α7nAChR><β-adrenergic receptor>
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Emil Khisamutdinov

BALL STATE UNIVERSITY, MUNCIE, IN

Exploratory lead · 28/100
Above-average budget
Active award
$560,460
FY 2025

Project Title

Nucleic Acid Nanoparticle-based Monoclonal Antibody Mimics

Grant Number:

2R15EB031388-02A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2021

End Date:

8/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Therapeutic monoclonal antibodies (mAbs) represent a rapidly expanding class of therapeutic agents, offering promise for treating various cancers, including prostate cancer (PC). However, their complex structure, elevated production cost, cross-reactivity, immunogenicity, and instability ha...

Research Terms

<19S Gamma Globulin><2'-deoxy-guanosine><7S Gamma Globulin><Academy><Administrative Supplement><Affinity><Animals><Aptamer Technology><Assay><Atomic Force Microscopy><Avidity><Basal Cell><Binding><Bioassay><Biologic Sciences><Biological><Biological Assay><Biological Sciences><Bioscience><Biosensing Technics><Biosensing Techniques><Blood Serum><Book Chapters><Bypass><Cancer Genes><Cancer Treatment><Cancer-Promoting Gene><Cancers><Cell Body><Cell Line><Cell Survival><Cell Viability><CellLine><Cells><Characteristics><Chemicals><Chemistry><Clinical Treatment Moab><Color><Coloring Agents><Complex><Culture Media><DNA><DNA Molecular Biology><DNA receptor><Dedications><Dehydration><Deoxyguanosine><Deoxyribonucleic Acid><Detection><Development><Diagnosis><Diagnostic><Disease><Disorder><Dyes><Enabling Factors><Engineering><Ensure><Environment><Equipment><FOLH><FOLH1><FOLH1 gene><Folate Hydrolase 1><Force Microscopy><Formazans><Foundations><Funding><Future><GCP2><Generalized Growth><Geometry><Glutamate Carboxypeptidase II><Goals><Growth><Hour><Human><Human Cell Line><IgA><IgD><IgE><IgG><IgM><Image><Immune response><Immunoglobulin A><Immunoglobulin D><Immunoglobulin E><Immunoglobulin G><Immunoglobulin M><In Vitro><Incubated><Indiana><Investigation><LNCaP><Label><Laboratories><Libraries><Life Sciences><Location><Logic><MAb Therapeutics><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Malignant neoplasm of prostate><Malignant prostatic tumor><Measures><Mediating><Metabolic><Methodology><Methods><Microfluidics><Mission><Modern Man><Modern Medicine><Molecular Biology><Molecular Interaction><Monoclonal Antibodies><N-Acetylated Alpha-Linked Acidic Dipeptidase 1><NAALAD1><NAALADase I><NIBIB><NIH><Nanoplatform><Nanotechnological platform><Nanotechnology><National Institute of Biomedical Imaging and Bioengineering><National Institutes of Health><Non-Polyadenylated RNA><Nucleic Acids><Oncogenes><Outcome><PC-3><PC-3 cell line><PC3><PC3 cell line><PSM><PSMA><Pathway interactions><Performance><Prevention><Production><Prostate CA><Prostate CA therapy><Prostate Cancer><Prostate Cancer therapy><Prostate malignancy><Prostate-Specific Membrane Antigen><Protocol><Protocols documentation><Publishing><Pump><RNA><RNA Gene Products><Reporter><Reporting><Research><Resistance><Resolution><Ribonucleic Acid><Scanning Force Microscopy><Science><Screening for Prostate Cancer><Series><Serum><Shapes><Specificity><Strains Cell Lines><Structure><Surface Plasmon Resonance><System><TLR7><TLR7 gene><Techniques><Temperature><Testing><Tetrazolium><Therapeutic><Therapeutic Agents><Therapeutic Intervention><Therapeutic Monoclonal Antibodies><Thermodynamic><Thermodynamics><Time><Tissue Growth><Toll-Like Receptor 7><Toxic effect><Toxicities><Transforming Genes><United States National Institutes of Health><Variant><Variation><anti-cancer therapy><antigen binding><antigen bound><aptamer><biologic><biosensing><body water dehydration><cancer therapy><cancer-directed therapy><conference><convention><cost><cross reactivity><cultured cell line><design><designing><detect prostate cancer><developmental><dimer><endonuclease><experiment><experimental research><experimental study><experiments><falls><flexibility><flexible><full scale manufacturing><growth media><host response><imaging><immune system response><immunogenicity><immunoresponse><in vitro testing><in vivo Model><innovate><innovation><innovative><insight><intervention therapy><large scale manufacturing><large scale production><mAbs><malignancy><mass production><meeting><meetings><melting><microscope imaging><microscopic imaging><microscopy imaging><model design><monoclonal Abs><monoclonal antibody drugs><monomer><nano><nano particle><nano tech><nano technology><nano-sized particle><nano-technological><nanoparticle><nanosized particle><nanotech><nanotechnological><nanotechnology platform><neoplasm/cancer><next generation><novel><nuclease><ontogeny><operation><operations><overexpress><overexpression><pathway><prostate cancer cell><prostate cancer cell line><prostate cancer detection><prostate cancer early detection><prostate cancer treatment><prostate tumor cell><resistant><resolutions><scaffold><scaffolding><sensor><small molecule><student training><summit><symposia><symposium><tech development><technology development><therapeutic mAbs><µfluidic>
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Benjamin Terry

BRIGHAM YOUNG UNIVERSITY, PROVO, UT

Exploratory lead · 28/100
Above-average budget
Active award
$556,876
FY 2025

Project Title

Precision-guided gastrointestinal therapy: a cheek-tethered capsule approach for targeted IBD disease treatment

Grant Number:

1R15DK144844-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/16/2025

End Date:

8/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Inflammatory bowel disease (IBD) affects millions of adults, significantly impairing quality of life and posing substantial challenges in diagnosis, monitoring, and treatment. Current methods for assessing and treating IBD have significant limitations, including invasive procedures, lack of localize...

Research Terms

<21+ years old><Academic Research Enhancement Awards><Address><Adult><Adult Human><Adverse effects><Affect><Alimentary Canal><Behavioral Research><Biological Agent><Biological Markers><Biological Products><Biomedical Engineering><Biomedical Research><Body Tissues><Bucca><Capsules><Cheek><Cheek structure><Chronic><Clinical Research><Clinical Study><Collaborations><Communication><Complex><Crohn disease><Crohn's><Crohn's disease><Crohn's disorder><Data><Data Analyses><Data Analysis><Device or Instrument Development><Devices><Diagnosis><Digestive Tract><Disease><Disease Management><Disorder><Disorder Management><Dose><Drug Delivery><Drug Delivery Systems><Drug Targeting><Drugs><Dysfunction><Economic Burden><Endoscopy><Engineering><Ensure><Environment><Evaluation><Excretory function><Fostering><Foundations><Functional disorder><GI Tract><Gastroenterology><Gastrointestinal Diseases><Gastrointestinal Motility><Gastrointestinal Tract><Gastrointestinal tract structure><Goals><Granulomatous Enteritis><Habits><Health><Health Care Costs><Health Costs><Hour><Human><Imaging Procedures><Imaging Technics><Imaging Techniques><Impairment><Inflammation><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Injury><Institution><Intervention><Length><Location><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Malnutrition><Maps><Measures><Mechanics><Medical Device><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medication><Mentors><Methods><Mission><Modeling><Modern Man><Monitor><NIBIB><NIH><NMR Imaging><NMR Tomography><National Institute of Biomedical Imaging and Bioengineering><National Institutes of Health><Nature><Navigation System><Nuclear Magnetic Resonance Imaging><Nutritional Deficiency><Outcome><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Peristalsis><Pharmaceutical Preparations><Physiologic><Physiological><Physiopathology><Position><Positioning Attribute><Procedures><QOL><Quality of life><R15 Mechanism><R15 Program><Recurrent pain><Research><Risk><Secure><Site><Students><Surgical sutures><Sutures><System><Technology><Testing><Therapeutic><Time><Tissues><Treatment Efficacy><Ulcerated Colitis><Ulcerative Colitis><Undernutrition><United States National Institutes of Health><Universities><Validation><Work><Zeugmatography><adulthood><alimentary tract><analog><bio-engineered><bio-engineers><bio-markers><biocompatibility><bioengineering><biologic marker><biological engineering><biologics><biomarker><biomaterial compatibility><biopharmaceutical><biotherapeutic agent><burden of disease><burden of illness><capsule><continuous monitoring><cost><data interpretation><design><designing><device development><dietary deficiency><digestive canal><disease burden><disease control><disorder control><dosage><drug/agent><effective therapy><effective treatment><eleocolitis><endoscopic imaging><excretion><fabrication><gastrointestinal><gastrointestinal disorder><improved><in vivo><inflammatory disease of the intestine><inflammatory disorder of the intestine><injuries><innovate><innovation><innovative><innovative technologies><instrument development><interest><intervention delivery><intervention efficacy><intestinal autoinflammation><malnourished><materials science><mechanic><mechanical><minimally invasive><multidisciplinary><next generation><novel><nutrition deficiency><nutrition deficiency disorder><nutritional deficiency disorder><open innovation><pathophysiology><patient oriented outcomes><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><primarily undergraduate institution><prototype><regional enteritis><side effect><skills><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic efficacy><therapy efficacy><treatment strategy><undergrad><undergraduate><undergraduate student><validations>
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PUDUR JAGADEESWARAN

UNIVERSITY OF NORTH TEXAS, DENTON, TX

Exploratory lead · 28/100
Above-average budget
Active award
$545,282
FY 2025

Project Title

Genetics of Thrombopoiesis

Grant Number:

2R15DK117384-02

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2018

End Date:

8/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Despite significant progress in understanding factors involved in megakaryocyte development and differentiation, much remains unknown about the mechanisms through which these factors affect megakaryocytes, particularly during maturation. This represents a critical gap in me...

Research Terms

<Affect><Applications Grants><Biologic Models><Biological Models><Biology><Bleeding><Blood Cells><Blood Platelet Count><Blood Platelet Number><Blood Platelets><Blood megakaryocyte><Bone Marrow><Bone Marrow Reticuloendothelial System><Brachydanio rerio><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cells><Characteristics><Circulation><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Code><Coding System><Danio rerio><Development><Disease><Disorder><Exhibits><Expression Signature><Fishes><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Fluorescence><Foundations><Future><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profile><Gene Expression Profiling><Genes><Genetic><Goals><Grant><Grant Proposals><Guide RNA><Hematopoiesis><Hematopoietic Cellular Control Mechanisms><Hemorrhage><Hemostasis><Hemostatic function><Human><Investigation><Knock-out><Knockout><Label><Mammalia><Mammals><Marrow platelet><Megakaryocytes><Megalokaryocyte><Mentors><Methods><Model System><Modeling><Modern Man><Molecular><Morphology><Paper><Pathway interactions><Peripheral Blood Cell><Physiologic><Physiological><Platelet Count><Platelet Count measurement><Platelet Number><Platelets><Polyploid><Polyploidy><Population><Principal Investigator><Production><Property><Proteins><Publications><Regulatory Pathway><Research><Role><Scientific Publication><Site><Sorting><Study models><Testing><Therapeutic><Thrombocytes><Thrombocytopenia><Thrombocytopoiesis><Thrombopenia><Thrombopoiesis><Training><Transcript><Transcript Expression Analyses><Transcript Expression Analysis><Transgenic Organisms><Zebra Danio><Zebra Fish><Zebrafish><analyze gene expression><blood cell formation><blood loss><cell sorting><comparative><compare to control><comparison control><developmental><differential expression><differentially expressed><experience><experiment><experimental research><experimental study><experiments><flow cytophotometry><gRNA><gene conservation><gene expression analysis><gene expression assay><gene expression pattern><gene expression signature><graduate student><indel><injured><innovate><innovation><innovative><insertion/deletion><insertion/deletion mutation><insight><knock-down><knockdown><knockout gene><mutant><new technology><novel><novel technologies><pathway><promoter><promotor><scRNA sequencing><scRNA-seq><seal><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><training opportunity><transcriptional differences><transcriptional profile><transcriptional profiling><transcriptional signature><transgenic><undergrad><undergraduate><undergraduate student>
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Niall George Howlett

UNIVERSITY OF RHODE ISLAND, KINGSTON, RI

Exploratory lead · 28/100
Above-average budget
Active award
$544,854
FY 2025

Project Title

A C. Elegans Model of Fanconi Anemia Neurological Syndrome

Grant Number:

1R15NS142899-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2025

End Date:

5/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Fanconi anemia (FA) is a genetic disease characterized by increased risk for bone marrow failure and cancer, with few therapeutic options. In recent years, central nervous system defects have become increasingly observed among FA patients. These include early-onset progressive and ir...

Research Terms

<AD related dementia><ADRD><ASD><Abnormal gait><Academic Research Enhancement Awards><Acceleration><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Animals><Autism><Autistic Disorder><BRCA1><BRCA1 Gene Product><BRCA1 Protein><BRCA1 gene><Behavioral Assay><Behavioral Paradigm><Binding Proteins><Biochemistry><Biological Chemistry><Birth Defects><Bone marrow failure><Breast Cancer 1 Gene><Breast Cancer 1 Gene Product><Breast Cancer Type 1 Susceptibility Gene><Breast Cancer Type 1 Susceptibility Protein><Breast-Ovarian Cancer Protein><C elegans><C. elegans><C.elegans><CNS Nervous System><Caenorhabditis elegans><Cancers><Canine Species><Canis familiaris><Causality><Cell Body><Cell-Cell Adhesion><Cells><Central Nervous System><ChIP Sequencing><ChIP-seq><ChIPseq><Characteristics><Clinical><Coin><Confocal Microscopy><Congenital Abnormality><Congenital Anatomical Abnormality><Congenital Defects><Congenital Deformity><Congenital Malformation><Congenital Pancytopenia><Defect><Diagnostic><Disease><Disorder><Dogs><Dogs Mammals><Dysfunction><Early Infantile Autism><Early Onset Gene Breast Cancer 1><Early Onset Protein Breast Cancer 1><Embryo><Embryonic><Ensure><Etiology><FA DNA repair pathway><FA-mediated DNA repair pathway><FANCD2><FANCD2 protein><Family><Fanconi Anemia><Fanconi Anemia Complementation Group Protein><Fanconi Anemia pathway><Fanconi Panmyelopathy><Fanconi anemia DNA repair pathway><Fanconi anemia complementation group D2><Fanconi anemia patient><Fanconi anemia protein><Fanconi anemia repair pathway><Fanconi dysplasia><Fanconi's Anemia><Functional disorder><Gait abnormality><Gait disorder><Gait disturbances><Gait dysfunction><Gait impairment><Genes><Genetic Diseases><Genome Stability><Genomic Stability><Genomics><Glutamates><Goals><Hereditary Breast Cancer 1><Human><Incubated><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Investigation><Kanner's Syndrome><L-Glutamate><Label><Laboratories><Life Expectancy><Ligand Binding Protein><Ligand Binding Protein Gene><Link><Maintenance><Malignant Neoplasms><Malignant Tumor><Modeling><Modern Man><Molecular><Molecular Target><Nematoda><Nematodes><Nerve Cells><Nerve Unit><Nervous System><Nervous System Diseases><Nervous System Disorder><Nervous System Physiology><Neural Cell><Neural Stem Cell><Neuraxis><Neurocyte><Neurodevelopmental Disorder><Neurologic><Neurologic Body System><Neurologic Disorders><Neurologic Manifestations><Neurologic Organ System><Neurologic Signs and Symptoms><Neurologic Symptoms><Neurologic function><Neurological><Neurological Development Disorder><Neurological Disorders><Neurological Manifestations><Neurological Signs and Symptoms><Neurological function><Neuronal Differentiation><Neurons><Ortholog><Orthologous Gene><Pathway interactions><Physiopathology><Play><Primary Erythroid Hypoplasia><Process><Prognosis><Protein Binding><Proteins><R15 Mechanism><R15 Program><RNA Seq><RNA sequencing><RNAseq><RNF53><Research Proposals><Risk><Role><Schizophrenia><Schizophrenic Disorders><Seizures><Structural defect><Structural malformation><Syndrome><Therapeutic><Therapeutic Intervention><Transcription Activation><Transcriptional Activation><Transgenic Animals><Visual><Walking impairment><accelerated aging><accelerated biological age><accelerated biological aging><adult neurogenesis><age acceleration><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><bound protein><brca 1 gene><canine><causation><cholinergic><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><congenital aplastic anemia><dementia praecox><differential expression><differentially expressed><disease causation><domestic dog><early onset><experiment><experimental research><experimental study><experiments><gene function><genetic condition><genetic disorder><glutamatergic><improved><insight><intellectual and developmental disability><intervention therapy><life span><lifespan><limited intellectual functioning><long read seq><long-read sequencing><long-read transcript sequencing><loved ones><malignancy><migration><neoplasm/cancer><nerve stem cell><nervous system development><nervous system function><neural><neural inflammation><neural manifestation><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurodevelopmental disease><neurogenesis><neurogenic progenitors><neurogenic stem cell><neuroinflammation><neuroinflammatory><neurological disease><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><neuropsychiatric disease><neuropsychiatric disorder><pathophysiology><pathway><patients with Fanconi anemia><postmitotic><prevent><preventing><progenitor and neural stem cells><progenitor cell expansion><progenitor expansion><replication stress><roundworm><schizophrenic><social role><stem and progenitor cell expansion><stem cell expansion><structural abnormalities><structural anomalies><structural mutation><structural variant><structural variation><transcriptional differences><transcriptome sequencing><transcriptomic sequencing>
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Dylan W Domaille

COLORADO SCHOOL OF MINES, GOLDEN, CO

Exploratory lead · 28/100
Above-average budget
Active award
$540,053
FY 2025

Project Title

Fluorescent Probes that Span the Spectrum for Multi-Color Imaging of Peroxynitrite in Living Cells

Grant Number:

1R15GM159260-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/5/2025

End Date:

8/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Reactive oxygen species and reactive nitrogen species are oxidative metabolites that play important roles in human health and disease. While these oxidative metabolites are required for a diverse array of cellular processes, including cell death, differentiation, and signali...

Research Terms

<1,2-Benzopyrones><1,2-benzopyrone><Active Oxygen><Apoplexy><Autoimmune Diseases><BODIPY><Biological><Biology><Boron><Brain Vascular Accident><Cancers><Cardiac Diseases><Cardiac Disorders><Cell Body><Cell Communication and Signaling><Cell Culture Techniques><Cell Death><Cell Differentiation><Cell Differentiation process><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Characteristics><Chemicals><Chemistry><Chronic><Color><Colorado><Coumarins><Detection><Development><Disease><Disorder><Dysfunction><Engineering><Eukaryotic Cell><Fluorescein><Fluorescence Light Microscopy><Fluorescence Microscopy><Fluorescent Probes><Functional disorder><Generations><Goals><H2O2><Health><Heart Diseases><Human><Hydrogen Peroxide><Hydroperoxide><Image><Imaging Device><Imaging Instrument><Imaging Tool><Inflammation><Intracellular Communication and Signaling><Learning><Libraries><Link><Macrophage><Malignant Neoplasms><Malignant Tumor><Maps><Measurement><Modeling><Modern Man><Molecular Probes><Mφ><Nitrogen><O element><O2 element><Optics><Organic Chemistry><Outcome><Oxidation-Reduction><Oxygen><Oxygen Radicals><Peer Review><Peroxonitrite><Physiopathology><Play><Population><Pro-Oxidants><Production><Property><Reaction><Reactive Nitrogen Species><Reactive Oxygen Species><Redox><Reporting><Research><Respiratory Disease><Respiratory System Disease><Respiratory System Disorder><Role><Schools><Signal Transduction><Signal Transduction Systems><Signaling><Specificity><Spectroscopy><Spectrum Analyses><Spectrum Analysis><Stroke><Structure><Structure-Activity Relationship><Students><Subcellular Process><Synthesis Chemistry><Synthetic Chemistry><Techniques><Technology><Tonka Bean Camphor><Training><Work><alpha benzopyrone><autoimmune condition><autoimmune disorder><autoimmunity disease><biologic><biological signal transduction><biomedical scientist><brain attack><cell culture><cell cultures><cellular differentiation><cerebral vascular accident><cerebrovascular accident><chemical kinetics><chemical structure function><coumarin><design><designing><developmental><fluorophore><heart disorder><imaging><imaging platform><imaging probe><improved><innovate><innovation><innovative><invention><kinetics (chemistry)><malignancy><necrocytosis><neoplasm/cancer><next generation><optical><oxidation reduction reaction><pathophysiology><pedagogy><peroxynitrite><public health relevance><scaffold><scaffolding><skills><social role><stroked><strokes><structure function relationship><tool><undergrad><undergraduate><undergraduate student>
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Suvobrata Chakravarty

SOUTH DAKOTA STATE UNIVERSITY, BROOKINGS, SD

Exploratory lead · 28/100
Above-average budget
Active award
$533,726
FY 2025

Project Title

Assessing the Strength of Weak Ties

Grant Number:

2R15GM134502-02

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/20/2019

End Date:

7/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Even though the paradigm shift in structure biology, heralded by AlphaFold2 of the deep-learning era, has transformed biological sciences, the true physics of the protein folding problem remains unresolved. For example, predicting the effects of mutations on protein stability remains an outstanding ...

Research Terms

<Address><Assay><Behavior><Bioassay><Bioinformatics><Biologic Sciences><Biological Assay><Biological Sciences><Biology><Biophysics><Bioscience><Cell Communication and Signaling><Cell Signaling><Chemistry><Chromatin><Complex><Comprehension><Computational toolkit><DNA><DNA mutation><Data Analyses><Data Analysis><Deoxyribonucleic Acid><Disease><Disorder><Electrostatics><Elements><Environment><Foundations><Genetic><Genetic Change><Genetic defect><Genetic mutation><Germ Lines><Goals><H-bond><Health><Human><Hydrogen Bonding><Hydrophobicity><Institution><Interdisciplinary Research><Interdisciplinary Study><Internet><Intervention><Intracellular Communication and Signaling><Investigation><Knowledge><Length><Life Sciences><Link><Lipid Bilayers><Macromolecular Structure><Mission><Modeling><Modern Man><Molecular Probes><Molecular Structure><Multidisciplinary Collaboration><Multidisciplinary Research><Mutation><NIH><Names><National Institutes of Health><Nature><Non-Polyadenylated RNA><Oncogenic><Organism><Phase><Physics><Play><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Preventative intervention><Protein Modification><Proteins><Proteome><Proteomics><Public Health><RNA><RNA Gene Products><Rationalization><Reagent><Research><Research Methodology><Research Methods><Ribonucleic Acid><Role><Science><Services><Signal Transduction><Signal Transduction Systems><Signaling><Structure><System><Testing><Therapeutic Intervention><United States National Institutes of Health><WWW><biological signal transduction><biophysical chemistry><biophysical foundation><biophysical principles><biophysical sciences><career><computational toolbox><computational tools><computational toolset><computerized tools><data interpretation><deep learning><deep learning method><deep learning strategy><design><designing><disease causing variant><disease-causing allele><disease-causing mutation><experiment><experimental research><experimental study><experiments><genome mutation><innovate><innovation><innovative><insight><insoluble aggregate><intervention for prevention><intervention therapy><lipid bilayer membrane><living system><macromolecule><mutant><name><named><naming><novel><pathogenic allele><pathogenic variant><prevent><preventing><prevention intervention><preventional intervention strategy><preventive intervention><protein aggregate><protein aggregation><protein folding><protein function><protein protein interaction><protein structure><protein structures><proteins structure><rapid assay><rapid test><rapid tests><research and methods><small molecule><social role><student training><tool><undergrad><undergraduate><undergraduate student><van der Waals force><web><web services><web-based service><world wide web>
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Mohammad Halim

KENNESAW STATE UNIVERSITY, KENNESAW, GA

Exploratory lead · 28/100
Above-average budget
Active award
$529,359
FY 2025

Project Title

Developing Next Generation Eutectic Solvents for Biomedical Applications

Grant Number:

1R15GM159257-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2025

End Date:

8/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

The utilization of protein- and enzyme-based drugs and products has experienced a substantial surge within the biomedical industry. The preservation of the integrity and stability of these drugs and products containing larger and more intricate molecules is vital over prolonged periods, presenting n...

Research Terms

<Academic Research Enhancement Awards><Achievement><Achievement Attainment><Address><Amino Acids><Antibodies><Award><Biological><Biology><Biomedical Research><Body Tissues><Carbamide><Characteristics><Chemistry><Communication><Computational Technique><Computer Models><Computerized Models><Development><Drug Delivery><Drug Delivery Systems><Drug Stability><Drug Therapy><Drugs><Elaqua XX><Enrollment><Ensure><Environment><Enzyme Gene><Enzymes><Esteroproteases><Friends><Goals><Grant><H-bond><High temperature of physical object><Hydration><Hydration status><Hydrogen Bonding><Individual><Industry><Interdisciplinary Research><Interdisciplinary Study><Knowledge><L-Proline><Laboratories><Learning><Liquid substance><Manuscripts><Marketing><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Measures><Medication><Mentors><Molecular><Molecular Configuration><Molecular Conformation><Molecular Stereochemistry><Motion><Movement><Multidisciplinary Collaboration><Multidisciplinary Research><NIH><Nanostructures><National Institutes of Health><Neutrons><Oral><Organ><Organic Solvents><Organic solvent product><Peptidases><Peptide Hydrolases><Peptides><Pharmaceutical Agent><Pharmaceutical Preparations><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Pharmacological Treatment><Pharmacotherapy><Preservation Technique><Proline><Property><Protease Gene><Proteases><Proteinases><Proteins><Proteolytic Enzymes><Publications><R-Series Research Projects><R01 Mechanism><R01 Program><R15 Mechanism><R15 Program><Reproduction><Research><Research Grants><Research Project Grants><Research Projects><Roentgen Rays><Scientific Publication><Secure><Single Crystal Diffraction><Solvents><Sperm><Spermatozoa><Stabilizing Agents><Structure><Students><System><Techniques><Therapeutic><Time><Tissues><Training><Transplantation><United States National Institutes of Health><Universities><Urea><Urea Carbamide><Ureaphil><Viscosity><Visualization><Work><X Ray Crystallographies><X-Radiation><X-Ray Crystallography><X-Ray Diffraction Crystallography><X-Ray Radiation><X-Ray/Neutron Crystallography><X-ray><Xray><Xray Crystallography><aminoacid><biobank><biocompatibility><biologic><biomaterial compatibility><biorepository><body movement><computational modeling><computational models><computer based models><computerized modeling><conference><conformation><conformational><conformational state><conformationally><conformations><convention><cost effective><design><designing><developmental><drug intervention><drug treatment><drug/agent><education planning><enroll><enzyme activity><enzyme therapy><experience><experiment><experimental research><experimental study><experiments><fluid><graduate school><graduate student><high temperature><insight><intermolecular interaction><liquid><nano-sized structures><nano-structures><next generation><pharmaceutical><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><physical property><posters><preservation><protein structure><protein structures><proteins structure><rational design><recruit><simulation><skills><sperm cell><stoichiometry><student mentoring><student training><student-led learning><summit><symposia><symposium><tool><transplant><undergrad><undergraduate><undergraduate student><zoosperm>
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Justin A Thornton

MISSISSIPPI STATE UNIVERSITY, MISSISSIPPI STATE, MS

Exploratory lead · 28/100
Above-average budget
Active award
$528,735
FY 2025

Project Title

Rational design of an adhesin-based pneumococcal vaccine targeting colonization

Grant Number:

2R15AI142537-02

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/17/2020

End Date:

8/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Currently licensed pneumococcal conjugate vaccines have been successful in preventing invasive disease; however, overall colonization rates have remained constant and serotype replacement by non-vaccine serotypes is now common. This suggests that most highly antigenic pneumococcal proteins may elici...

Research Terms

<ABC Transport Protein><ABC Transporter Protein><ABC Transporters><ATP-Binding Cassette Transporters><Adherence><Affect><Age><Antibodies><Bacterial Adhesins><Binding><Binding Proteins><Biochemistry><Biological Chemistry><Biomedical Research><Blood Serum><Capsules><Cell Body><Cells><Choline><Complement><Complement Proteins><Conjugate Vaccines><D pneumoniae><D. pneumoniae><DNA Molecular Biology><Development><Diplococcus pneumoniae><Disease><Disorder><Economic Burden><Epithelial Cells><Esteroproteases><Far-Western Blotting><Female><Funding><Glycans><Goals><Grant><Health><Human><IgA><Immune response><Immunity><Immunize><Immunoblotting><Immunoglobulin A><Immunology><Individual><Invaded><Knowledge><Lead><Licensing><Ligand Binding Protein><Ligand Binding Protein Gene><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediating><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Metals><Mice><Mice Mammals><Microbiology><Mission><Mississippi><Modern Man><Molecular Biology><Molecular Interaction><Mucosa><Mucosal Tissue><Mucous Membrane><Murine><Mus><NIH><National Institutes of Health><Pb element><Peptidases><Peptide Hydrolases><Phase><Play><Pneumococcal Colonization><Pneumococcal Infections><Pneumococcal conjugate vaccine><Pneumococcal vaccine><Pneumococcus><Polysaccharides><Population><Prevalence><Process><Protease Gene><Proteases><Protein Binding><Proteinases><Proteins><Proteolytic Enzymes><Public Health><Reaction><Receptor Protein><Research><Respiratory Epithelium><Role><S pneumoniae><S. pneumoniae><Sampling><Serotyping><Serum><Streptococcus pneumoniae><Streptococcus pneumoniae Infections><Streptococcus pneumoniae PspA protein><Streptococcus pneumoniae vaccine><Structure of respiratory epithelium><Surface Proteins><Techniques><Testing><Therapeutic><United States National Institutes of Health><Vaccination><Vaccines><Variant><Variation><West-Western Blotting><Western Blotting><Western Immunoblotting><Work><adhesin><ages><airway epithelium><anti-microbial peptide><bound protein><candidate identification><capsule><complementation><design><designing><developmental><graduate student><heavy metal Pb><heavy metal lead><host response><immune system response><immunogenic><immunoresponse><inhibiting antibody><innovate><innovation><innovative><insight><male><mouse model><murine model><mutant><new vaccines><next generation vaccines><novel><novel vaccines><pneumococcal disease><pneumococcal surface protein A><pneumococcus infection><polyclonal antibody><pressure><prevent><preventing><programs><protective effect><protein blotting><rational design><receptor><respiratory tract epithelium><response><social role><socio-economic><socio-economically><socioeconomically><socioeconomics><success><synergism><therapeutically effective><undergrad><undergraduate><undergraduate student><vaccine candidate><vaccinology><♀><♂>
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Ryan D Zarzycki

ARCADIA UNIVERSITY, GLENSIDE, PA

Exploratory lead · 28/100
Above-average budget
Active award
$520,154
FY 2025

Project Title

Determining the effects of non-invasive brain stimulation to improve quadriceps muscle function after ACL reconstruction.

Grant Number:

1R15HD118518-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/6/2025

End Date:

5/5/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Quadricep muscle impairments persist for years after anterior cruciate ligament reconstruction (ACLR). They are linked to poor long-term outcomes including the early onset of post-traumatic knee osteoarthritis (PTOA), which is thought to result from altered movement patterns...

Research Terms

<ACL injury><ACL reconstruction><ACL repair><ANOVA><Active Follow-up><Address><Age><Analysis of Variance><Anodes><Behavioral><Blinded><Body Weight><Chronic><Clinical Trials><Coupled><Coxa><Development><Differences between sexes><Differs between sexes><Discipline><Effectiveness><Electromyography><Exercise><Female><Future><Goals><Health><Health Care Systems><Hip><Hip region structure><Impairment><Individual><Injury><Isokinetic Exercise><Isokinetics><Isometric Exercise><Isometrics><Isotonic Exercise><Isotonics><Knee><Knee Osteoarthritis><Knee joint><Link><Measures><Medical Rehabilitation><Motor><Movement><Muscle><Muscle Tissue><Muscle function><Muscle-Setting Exercise><Operative Procedures><Operative Surgical Procedures><Outcome><Participant><Pattern><Performance><Postoperative><Postoperative Period><Prevalence><Protocol><Protocols documentation><QOL><Quality of life><Randomized><Randomized, Controlled Trials><Rehabilitation><Rehabilitation therapy><Research><Risk><Risk Reduction><Running><Sex Differences><Sexual differences><Static Exercise><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Surface><Surgical><Surgical Interventions><Surgical Procedure><Techniques><Testing><Torque><Training><Transcranial magnetic stimulation><Traumatic Arthritis><Traumatic Arthropathy><United States><Variance Analyses><Walking><active followup><ages><anterior cruciate ligament injury><anterior cruciate ligament reconstruction><anterior cruciate ligament repair><body movement><clinical relevance><clinically relevant><comparing females and males><comparing women and men><design><designing><developmental><early onset><evidence base><female treatment><females compared to males><females compared with males><females versus males><females vs. males><follow up><follow-up><followed up><followup><improved><injuries><knee OA><knee joint OA><knee joint osteoarthritis><male><muscular><neural><neural control><neural regulation><neuromodulation><neuromodulatory><neuroregulation><non-invasive brain stimulation><post-operative rehab><post-operative rehabilitation><post-traumatic osteoarthritis><postoperative rehab><postoperative rehabilitation><quadriceps><quadriceps muscle><randomisation><randomization><randomized control trial><randomly assigned><recruit><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><rehab therapy><rehabilitative><rehabilitative therapy><resistance exercise><resistance training><restoration><risk-reducing><safety and feasibility><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><statistical analysis><surgery><transcranial direct current stimulation><treat females><treat women><treatment among females><treatment among women><treatment in females><treatment in women><undergrad><undergraduate><undergraduate student><vastus medialis><women compared to men><women compared with men><women versus men><women vs. men><women's treatment><♀><♂>
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CLARK A LINDGREN

GRINNELL COLLEGE, GRINNELL, IA

Exploratory lead · 28/100
Above-average budget
Active award
$515,078
FY 2025

Project Title

Investigating the role of pH in presynaptic homeostatic potentiation at the vertebrate neuromuscular junction

Grant Number:

1R15NS139201-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2025

End Date:

8/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

This project continues thirty-two years of research with undergraduate students at Grinnell College, who participate in all aspects of the research. My laboratory studies synaptic transmission at the vertebrate neuromuscular junction (NMJ). This project will focus on a phenomenon called presynaptic ...

Research Terms

<ACh Receptors><ASIC channel><ATP phosphohydrolase (Ca(2+)-transporting)><Academic Research Enhancement Awards><Acetylcholine><Acetylcholine Receptors><Action Potentials><Buffers><CNS Nervous System><Ca(2+)-Transporting ATPase><Ca2+ ATPase><Ca2+ transporting ATPase><Calcium><Calcium ATPase><Calcium Adenosine Triphosphatase><Calcium Pump><Cell Communication and Signaling><Cell Signaling><Cell membrane><Central Nervous System><Chemosensitization><Chemosensitization/Potentiation><Cholinergic Receptors><Cholinoceptive Sites><Cholinoceptors><Communication><Cytoplasmic Membrane><Detection><Doctor of Philosophy><Ensure><Faculty><Feedback><Goals><Grant><H+ element><Hydrogen Ions><Intracellular Communication and Signaling><Investigators><Knowledge><Laboratory Study><Laser Electromagnetic><Laser Radiation><Lasers><Learning><Link><Measures><Membrane><Mice><Mice Mammals><Murine><Mus><Muscle><Muscle Tissue><Myoneural Junction><NIH><National Institutes of Health><Nature><Nerve><Nerve Transmitter Substances><Neural Transmission><Neuraxis><Neuromuscular Junction><Neurotransmitters><Peripheral Nervous System><Ph.D.><PhD><Physiologic><Physiological><Plasma Membrane><Potentiation><Process><Productivity><Protons><R15 Mechanism><R15 Program><Research><Research Personnel><Researchers><Role><Sarcoplasmic Reticulum><Science><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Student Selections><Students><Synapses><Synaptic><Synaptic Cleft><Synaptic Transmission><Testing><Training><Training Support><United States National Institutes of Health><Virus><acid-sensing ion channels><biological signal transduction><calcium transporting ATPase><career><college><collegiate><experience><experiment><experimental research><experimental study><experiments><extracellular><graduate school><interest><matriculation><medical college><medical schools><meeting><meetings><membrane structure><muscular><neurotransmitter release><plasmalemma><postsynaptic><presynaptic><prevent><preventing><programs><school of medicine><social role><student research><student-led research><synapse><undergrad><undergraduate><undergraduate research><undergraduate student>
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JEFFREY D EVANSECK

DUQUESNE UNIVERSITY, PITTSBURGH, PA

Exploratory lead · 28/100
Above-average budget
Active award
$507,121
FY 2025

Project Title

RNA homodimerization strand displacement pathways to extended duplexes: Atomistic details for a mechanistic paradigm to identify unique antiviral targets for current and emerging viral pandemics

Grant Number:

1R15AI191143-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/21/2025

End Date:

7/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Kissing complexes (KC) and extended duplexes (ED) represent dynamic RNA structures whose interconversion is an example of strand displacement reactions that has been implicated in playing vital roles in several viruses, influencing a broad spectrum of biochemical processes including ...

Research Terms

<2019 novel corona virus><2019 novel coronavirus><2019-nCoV><Address><Anti-viral Agents><Anti-viral Drug Resistance><Anti-viral Drug Resistant><Anti-viral Therapy><Anti-viral resistance><Antisense Agent><Antisense Oligonucleotides><Bacteria KatF protein><Bacteria rpoS protein><Bacteria sigma factor 38 protein><Bacteria sigma factor KatF protein><Bacteria sigma factor S protein><Benchmarking><Best Practice Analysis><Binding><Biochemical><Biochemical Process><Biological><Biophysics><COVID-19 virus><COVID19 virus><Cell Communication and Signaling><Cell Signaling><Chaperone><Chemistry><CoV-2><CoV2><Complex><Computational Technique><Computer software><Computing Methodologies><Conserved Sequence><Coronaviridae><Coronavirus><Crystallographies><Crystallography><DNA Recombination><Data><Data Reporting><Dimerization><Docking><Drug Combinations><Drug Design><Drug Targeting><Drug resistance><Drugs><E coli><E. coli><Elasticity><Elements><Escherichia coli><Foundations><Free Energy><Future><Generations><Genetic Recombination><Genome><Geometry><Goals><HCV><HCV disease><HIV-1><HIV-I><HIV1><Health><Hepatitis C><Hepatitis C virus><Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted><Hepatitus C><Homodimerization><Human Immunodeficiency Virus Type 1><Human immunodeficiency virus 1><Immune response><Intracellular Communication and Signaling><Investigators><Investments><Kinetics><Knowledge><Life><Life Cycle><Life Cycle Stages><Medication><Messenger RNA><Methodology><Methods><Modeling><Molecular Chaperones><Molecular Interaction><NIH><National Institutes of Health><Non-Polyadenylated RNA><Nucleocapsid><Oligo><Oligonucleotides><Orthocoronavirinae><Outcome><Pathway interactions><Pharmaceutical Agent><Pharmaceutical Preparations><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Physiologic><Physiological><Play><Process><Protein Dimerization><Proteins><Publications><RNA><RNA Binding><RNA Gene Products><RNA Viruses><RNA bound><RNA targeting drug><RNA targeting therapeutics><RNA-targeting therapy><Reaction><Recombination><Reporting><Research><Research Personnel><Researchers><Resistance><Ribonucleic Acid><Role><RpoS><SARS Virus><SARS corona virus><SARS corona virus 2><SARS coronavirus><SARS-Associated Coronavirus><SARS-CO-V2><SARS-COVID-2><SARS-CoV><SARS-CoV-1><SARS-CoV-2><SARS-CoV2><SARS-Related Coronavirus><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Sampling><Scientific Publication><Severe Acute Respiratory Coronavirus><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome Virus><Severe Acute Respiratory Syndrome corona virus><Severe Acute Respiratory Syndrome coronavirus><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Signal Transduction><Signal Transduction Systems><Signaling><Single Crystal Diffraction><Site><Small RNA><Software><Structure><Students><System><Talents><Techniques><Testing><Therapeutic Intervention><Thermodynamic><Thermodynamics><Training><United States National Institutes of Health><Validation><Viral><Viral Drug Resistance><Virus><Work><Wuhan coronavirus><X Ray Crystallographies><X-Ray Crystallography><X-Ray Diffraction Crystallography><X-Ray/Neutron Crystallography><Xray Crystallography><anti-viral compound><anti-viral development><anti-viral drug development><anti-viral drugs><anti-viral medication><anti-viral resistant><anti-viral therapeutic><anti-viral therapeutic development><anti-viral therapy development><anti-virals><antisense oligo><antiviral development><antiviral drug development><antiviral therapeutic development><antiviral therapy development><benchmark><biologic><biological signal transduction><biophysical foundation><biophysical principles><biophysical sciences><comparative><computational chemistry><computational methodology><computational methods><computer based method><computer methods><computing method><corona virus><coronavirus disease 2019 virus><coronavirus disease-19 virus><data representation><data representations><develop drug resistance><developing anti-viral agent><developing anti-viral drug><developing anti-viral therapeutic><developing anti-viral therapy><developing antiviral agent><developing antiviral drug><developing antiviral therapeutic><developing antiviral therapy><dimer><drug resistance development><drug resistant><drug/agent><experience><experiment><experimental research><experimental study><experiments><genomic RNA><graduate student><hCoV19><hep C><hepC><hepatitis non A non B><host response><immune system response><immunoresponse><insight><interest><intervention therapy><life course><mRNA><nCoV2><new approaches><non A, non B hepatitis><non-A, non-B hepatitis><novel><novel approaches><novel strategies><novel strategy><oligos><pathogen><pathway><pharmaceutical><public health relevance><resistance to Drug><resistance to anti-viral><resistant><resistant to Drug><resistant to anti-viral><severe acute respiratory syndrome-CoV><sigma(38) protein, Bacteria><sigma(S) protein, Bacteria><simulation><small molecule><social role><student training><trustworthiness><undergrad><undergraduate><undergraduate student><validations><viral RNA><viral hepatitis C><viral infectious disease treatment><viral pandemic><virtual><virus RNA>
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Dali Liu

LOYOLA UNIVERSITY OF CHICAGO, CHICAGO, IL

Exploratory lead · 28/100
Above-average budget
Active award
$503,535
FY 2025

Project Title

Developing Novel Protein-based GABA Sensor Modules Using PLP-dependent GabR Regulators

Grant Number:

1R15GM160979-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/4/2025

End Date:

8/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

The proposed development of novel protein-based GABA sensor modules using PLP-dependent GabR regulators aims to facilitate the understanding of GABAergic neurotransmission. GabR, a bacterial transcription regulator, shows remarkable specificity for GABA through a reversible covalent bond with PLP, t...

Research Terms

<2-photon microscopy><4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><AD/HD><ADHD><ASD><Address><Affinity><Aminalon><Aminalone><Animals><Area><Assay><Attention deficit hyperactivity disorder><Autism><Autistic Disorder><Axon Terminals><B subtilis><B. subtilis><Bacillus subtilis><Bacteria><Binding><Bioassay><Biological Assay><Biological Function><Biological Process><Biosensor><Body Tissues><Brain><Brain Nervous System><CNS Nervous System><Carbon><Cell Body><Cell Communication and Signaling><Cell Culture Techniques><Cell Signaling><Cells><Central Nervous System><Characteristics><Chemicals><Coloring Agents><Computational toolkit><Crystallographies><Crystallography><Cysteine><Data><Detection><Development><Dyes><Early Infantile Autism><Education and Outreach><Encephalon><Extracellular Fluid><FRET><Fluorescence><Fluorescence Resonance Energy Transfer><Förster Resonance Energy Transfer><GABA><GABA transporter><Gene Transcription><GeneHomolog><Genetic Transcription><Glia><Glial Cells><Glutamates><Grant><Half-Cystine><High School Student><Homolog><Homologous Gene><Homologue><Human><Image><In Vitro><Infantile Autism><Instruction and Outreach><Intracellular Communication and Signaling><Kanner's Syndrome><Kinetics><Kolliker's reticulum><L-Cysteine><L-Glutamate><Label><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Mental Depression><Mental Health><Mental Hygiene><Methods><Modern Man><Molecular Configuration><Molecular Conformation><Molecular Interaction><Molecular Stereochemistry><Monitor><Movement><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Transmitter Substances><Nerve Unit><Neural Cell><Neuraxis><Neurocyte><Neuroglia><Neuroglial Cells><Neurologic><Neurological><Neuronal Transmission><Neurons><Neuropharmacology><Neurotransmitters><Nitrogen><Noise><Non-neuronal cell><Nonneuronal cell><Organic Synthesis><PTSD><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Posttraumatic Neuroses><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Presynaptic Nerve Endings><Presynaptic Terminals><Production><Protein Conformation><Proteins><Psychological Health><RNA Expression><Research><Schizophrenia><Schizophrenic Disorders><Secondary School Student><Secondary Student><Signal Transduction><Signal Transduction Systems><Signaling><Site><Slice><Source><Specificity><Spectroscopy><Spectrum Analyses><Spectrum Analysis><Structure><Surface><Surface Proteins><Synaptic Boutons><Synaptic Cleft><Synaptic Terminals><System><Time><Tissue imaging><Tissues><Training><Training and Outreach><Transcription><Transmission><Tutoring and Outreach><Variant><Variation><Work><absorption><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><axon signaling><axon-glial signaling><axonal signaling><biological sensor><biological signal transduction><body movement><cell culture><cell cultures><chemical reaction><computational toolbox><computational tools><computational toolset><computerized tools><conformation><conformational><conformational state><conformationally><conformations><covalent bond><dementia praecox><depression><design><designing><developmental><dimer><drug discovery><experiment><experimental research><experimental study><experiments><fluorophore><gamma-Aminobutyric Acid><glia signaling><glial signaling><glutamatergic><high schoolers><imaging><improved><in vitro Assay><in vivo><inhibitor><insight><monomer><nerve cement><nerve signaling><neural><neural signaling><neuronal><neuronal signaling><neurotransmission><non-natural amino acids><non-proteinogenic amino acids><nonproteinogenic amino acids><novel><post-trauma stress disorder><posttrauma stress disorder><pre-synaptic nerve><pre-synaptic neurons><presynaptic nerve><presynaptic neurons><rational design><response><schizophrenic><screening><screenings><sensor><shunt pathway><tool><transmission process><traumatic neurosis><two photon excitation microscopy><two photon microscopy><undergrad><undergraduate><undergraduate student><unnatural amino acids><γ-Aminobutyric Acid>
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Aaron Morgan Leconte

SCRIPPS COLLEGE, CLAREMONT, CA

Exploratory lead · 28/100
Above-average budget
Active award
$503,298
FY 2025

Project Title

High-throughput characterization and engineering of brighter luciferases

Grant Number:

2R15GM135860-02

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/20/2019

End Date:

8/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Bioluminescence Imaging (BLI) is a non-invasive method that enables the monitoring of in vitro and in vivo biological events, cells, and molecules. In BLI, the bioluminescent enzyme luciferase is used as a reporter. The detection limit, versatility, and temporal and spatial resolutio...

Research Terms

<Alanine><American><Amino Acids><Assay><Award><Bioassay><Biochemical><Biological><Biological Assay><Biological Function><Biological Process><Biomedical Research><Body Tissues><C-terminal><Cashew><Cashew nut><Catalysis><Cell Body><Cell Communication><Cell Interaction><Cell-to-Cell Interaction><Cells><Color><Complex><DNA Molecular Biology><DNA mutation><Data><Development><Directed Molecular Evolution><Disease><Disorder><Engineering><Enzyme Gene><Enzymes><Evaluation><Event><Fireflies><Firefly Luciferases><Fluorescence><Funding><Genetic Change><Genetic defect><Genetic mutation><Grant><Health><Home><Human><Image><Imaging Device><Imaging Instrument><Imaging Tool><In Vitro><Institution><Knowledge><Lampyridae><Libraries><Light><Luciferase Immunologic><Luciferases><Methodology><Methods><Modern Man><Molecular Biology><Molecular Configuration><Molecular Conformation><Molecular Stereochemistry><Monitor><Mutate><Mutation><O element><O2 element><Organism><Output><Oxygen><Penetrance><Photinus><Photinus luciferin 4 monooxygenase><Photons><Photoradiation><Pistachio><Pistachio Nuts><Point Mutation><Position><Positioning Attribute><Productivity><Protein Region><Proteins><Reporter><Research><Research Assistant><Resolution><Role><Scanning><Students><TS-1><Technology><Tissues><Variant><Variation><Visualization><Whole Organism><Work><aminoacid><biologic><bioluminescence imaging><bioluminescent imaging><career><cell type><chemical reaction><conformation><conformational><conformational state><conformationally><conformations><detection limit><developmental><directed evolution><enzyme activity><experiment><experimental research><experimental study><experiments><flexibility><flexible><genome mutation><high redshift><homes><imaging><imaging probe><improved><in vivo><insight><living system><luciferin><method development><mutant><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><redshift><resolutions><small molecule><social role><spatial and temporal><spatial temporal><spatiotemporal><student engagement><student motivation><student participation><student training><tool><undergrad><undergraduate><undergraduate education><undergraduate student><whole animal imaging>
View Full Project Details on NIH Reporter
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MARGARET H ZELLER

UNIVERSITY OF CINCINNATI, CINCINNATI, OH

Exploratory lead · 26/100
Above-average budget
Career award
$830,307
FY 2024

Project Title

KL2 Training Program

Grant Number:

5KL2TR001426-09

Activity Code:

KL2

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/14/2015

End Date:

9/30/2025

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

The University of Cincinnati Center for Clinical and Translational Science and Training (CCTST) has an excellent record of accomplishment in training KL2 Scholars. The KL2 program has appointed 24 Scholars (50% women, 12.5% underrepresented) from diverse disciplines since 2009 (2 per year, for 2- to...

Research Terms

<3-D><3-Dimensional><3D><Active Learning><Address><American Heart Association><Appointment><Award><Biomedical Research><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Clinical><Clinical Investigator><Clinical Research><Clinical Sciences><Clinical Study><Collaborations><Communication><Communities><Cooperative Learning><Decrease disparity><Department of Defense><Dimensions><Direct Costs><Discipline><Educational workshop><Ensure><Ethnic Origin><Ethnicity><Experiential Learning><Faculty><Fostering><Funding><Future><Gender><Goals><Grant><Health><Health system><Industry><Institution><International><Investigators><Journals><K-Awards><K-Series Research Career Programs><Leadership><Learning><Lower disparity><Magazine><Manuscripts><Measures><Mentors><NCATS><National Center for Advancing Translational Sciences><Outcome><Pathway interactions><Position><Positioning Attribute><Principal Investigator><Program Development><Program Evaluation><Publishing><R-Series Research Projects><R01 Mechanism><R01 Program><Race><Races><Research><Research Career Program><Research Ethics><Research Grants><Research Methodology><Research Methods><Research Personnel><Research Project Grants><Research Projects><Researchers><Scholars Program><Science><Secure><Sight><Site><Sum><Training><Training Programs><Translational Research><Translational Science><Translations><Universities><Vision><Woman><Work><Workshop><burn-out><burnout><career><career development><clinical center><design><designing><disparity reduction><evidence base><experience><health outcome disparity><health outcome inequality><health outcome inequity><improved><inequitable health outcome><innovate><innovation><innovative><life span><lifespan><meeting><meetings><method development><mitigate disparity><multidisciplinary><next generation><pathway><population health><programs><racial><racial background><racial origin><recruit><reduce disparity><reduction in disparity><research and methods><scale up><skill acquisition><skill development><skills><success><three dimensional><translation><translation research><translational investigation><translational investigator><translational researcher><translational scientist><unequal health outcome><visual function><workforce needs>
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George Vidal

JAMES MADISON UNIVERSITY, HARRISONBURG, VA

Exploratory lead · 26/100
Training-friendly
Career award
$210,600
FY 2024

Project Title

Integrin Functions in Shaping Cortical Circuits

Grant Number:

5K01NS107723-05

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2020

End Date:

4/30/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY The candidate is a tenure-track assistant professor at James Madison University, with the overarching goal of understanding the development of the structure and function of the cerebral cortex to better diagnose and treat neurodevelopmental disorders. His long-term research objective...

Research Terms

<0-11 years old><ASD><Adhesion Molecule><Advisory Committees><Affect><Age><American><Anatomic Sites><Anatomic structures><Anatomy><Area><Autism><Autistic Disorder><Award><Axon><Behavior><Behavioral><Binding><Brain><Brain Nervous System><CD61><CD61 Antigens><CNS plasticity><Cell Adhesion Molecule Gene><Cell Adhesion Molecules><Cell Body><Cell Function><Cell Locomotion><Cell Migration><Cell Movement><Cell Physiology><Cell Process><Cell-Extracellular Matrix><Cells><Cellular Function><Cellular Migration><Cellular Motility><Cellular Physiology><Cellular Process><Cerebral cortex><Child><Child Youth><Children (0-21)><Data><Dendrites><Dendritic Spines><Development><Diagnosis><ECM><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Embryo><Embryonic><Encephalon><Equilibrium><Event><Extracellular Matrix><Funding><GP IIIa><GP3A><GPIIIa><Generalized Growth><Genetic Alteration><Genetic Change><Genetic defect><Glia><Glial Cells><Goals><Growth><ITGB3><ITGB3 gene><In Vitro><Infantile Autism><Institution><Integrin Beta 3><Integrin beta Chains><Integrin beta Subunits><Integrin beta3><Integrin β Chains><Integrin β Subunits><Integrin β3><Integrins><Integrins Extracellular Matrix><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Kanner's Syndrome><Knock-out><Knockout><Knowledge><Kolliker's reticulum><Lead><Link><Mediating><Mentors><Mentorship><Mice><Mice Mammals><Molecular Interaction><Morphology><Murine><Mus><Mutation><NAIT><NIH><NINDS><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><National Institutes of Health><Nerve Cells><Nerve Unit><Nervous System><Neural Cell><Neural Transmission><Neuranatomies><Neuranatomy><Neurites><Neuroanatomies><Neuroanatomy><Neurocyte><Neurodevelopmental Disorder><Neuroglia><Neuroglial Cells><Neurologic Body System><Neurologic Organ System><Neurological Development Disorder><Neuronal Plasticity><Neurons><Neurophysiology / Electrophysiology><Non-neuronal cell><Nonneuronal cell><PTP gene><Pb element><Physiologic><Physiological><Platelet Fibrinogen Receptor, Beta Subunit><Platelet GPIIIa><Platelet Glycoprotein IIIa><Platelet Membrane Glycoprotein IIIa><Position><Positioning Attribute><Predisposition gene><Prefrontal Cortex><Process><Public Health><Pyramidal neuron><Research><Role><Secure><Shapes><Social Behavior><Structure><Subcellular Process><Susceptibility Gene><Synaptic Transmission><Task Forces><Telencephalon><Testing><Tissue Growth><United States National Institutes of Health><Universities><Virginia><advisory team><ages><autism spectral disorder><autism spectrum disorder><autistic behavior><autistic behaviour><autistic spectrum disorder><autistic-like behavior><balance><balance function><beta Integrins><career><cell adhesion protein><cell motility><cell type><central nervous system plasticity><conditional knock-out><conditional knockout><critical period><dendrite spine><density><design><designing><developmental><developmental neurobiology><electrophysiological><excitatory neuron><gene function><genome mutation><heavy metal Pb><heavy metal lead><hippocampal pyramidal neuron><immunoneurology><in vivo><innovate><innovation><innovative><intellectual and developmental disability><kids><limited intellectual functioning><loss of function><migration><nerve cement><neural><neural plasticity><neurodevelopmental disease><neuroimmunology><neuronal><neuroplastic><neuroplasticity><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><ontogeny><postnatal><predisposing gene><professor><programs><reconstruction><social role><sociobehavior><sociobehavioral><susceptibility allele><susceptibility locus><susceptibility variant><synapse function><synaptic function><tenure process><tenure track><youngster><β-Integrins>
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Jinglin Fu

RUTGERS THE STATE UNIV OF NJ CAMDEN, CAMDEN, NJ

Exploratory lead · 20/100
Solid budget
Active award
$486,291
FY 2025

Project Title

R15: Enhancement of Genome Editing in Hematopoietic Stem Cells by Nucleic Acids Nanoparticles Delivery of CRISPR/CAS System

Grant Number:

1R15HL177745-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2028

Project Abstract

Editing hematopoietic stem cells (HSCs) at the genetic level is a rapidly progressing field that has the potential to revolutionize the treatment of genetic blood disorders and related diseases. However, the effective implementation of HSCs therapy is hampered by challenges in the lack of efficient ...

Research Terms

<Affect><Assay><Bioassay><Biological Assay><Blood Diseases><Blood Precursor Cell><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Line><Cell Nucleus><Cell Survival><Cell Viability><CellLine><Cells><Characteristics><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Complex><DNA Therapy><Defense Mechanisms><Development><Disease><Disorder><Education><Educational aspects><Evaluation><Family><Gene Delivery><Gene Transfer Clinical><Genes><Genetic><Genetic Diseases><Genetic Intervention><Genetic Materials><Geometry><Goals><HSC transplantation><Hb SS disease><HbSS disease><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematopoietic><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Hematopoietic stem cells><Hemoglobin S Disease><Hemoglobin sickle cell disease><Hemoglobin sickle cell disorder><Human><In Vitro><Individual><Knock-in><Knowledge><Leukemic Cell><Ligands><Lytotoxicity><Medical Research><Methods><Mice><Mice Mammals><Modern Man><Murine><Mus><Nanotechnology><Nucleic Acids><Nucleus><Outcome><Outcome Assessment><Outcomes Research><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Preparation><Public Health><Receptor Protein><Research><STEM Education><STEM knowledge><Safety><Science, Technology, Engineering and Math Education><Science, Technology, Engineering and Mathematics Education><Shapes><Sickle Cell Anemia><Specificity><Strains Cell Lines><Structure><System><Techniques><Technology><Testing><Therapeutic Intervention><Toxic effect><Toxicities><assess effectiveness><blood cell progenitor><blood disorder><blood progenitor><blood stem cell><blood stem cell transplantation><blood-forming stem cell><clinical applicability><clinical application><cultured cell line><cytotoxicity><deliver mRNA><deliver messenger RNA><delivery system for mRNA><design><designing><determine effectiveness><developmental><disease causing variant><disease-causing allele><disease-causing mutation><effectiveness assessment><effectiveness evaluation><evaluate effectiveness><examine effectiveness><gene repair therapy><gene therapeutics><gene therapy><gene-based therapeutic><gene-based therapeutics><gene-based therapy><genes therapeutic><genes therapeutics><genetic condition><genetic disorder><genetic therapy><genome editing><genomic editing><genomic therapy><graduate student><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor><hematopoietic progenitor cell transplantation><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><improved><innovate><innovation><innovative><insight><interdisciplinary approach><intervention therapy><knockin><knockout gene><mRNA Translation><mRNA delivery><messenger RNA delivery><multidisciplinary approach><nano medicinal><nano medicine><nano particle><nano particle delivery><nano tech><nano technology><nano-sized particle><nano-technological><nanomedicinal><nanomedicine><nanoparticle><nanoparticle delivered><nanoparticle delivery><nanosized particle><nanotech><nanotechnological><new technology><novel technologies><pathogenic allele><pathogenic variant><patient oriented outcomes><precise genome editing><preparations><progenitor biology><progenitor cell based therapy><progenitor cell biology><progenitor cell therapy><progenitor cell treatment><progenitor therapy><progenitor treatment><psychological defense mechanism><receptor><science education><science, technology, engineering and math knowledge><science, technology, engineering and mathematics knowledge><self assembly><sickle cell disease><sickle cell disorder><sickle disease><sicklemia><stem and progenitor biology><stem and progenitor cell therapy><stem cell based therapy><stem cell biology><stem cell mediated therapy><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><therapeutic gene><translation strategy><translational approach><translational strategy><undergrad><undergraduate><undergraduate student><uptake>
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MARK LAUBACH

AMERICAN UNIVERSITY, Washington, DC

Exploratory lead · 20/100
Solid budget
Active award
$476,496
FY 2025

Project Title

Cortical actions of opioids on reward-guided decision making

Grant Number:

1R15DA062121-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/15/2025

End Date:

7/31/2028

Project Abstract

This research investigates the role of opioid signaling in decision-making within the rat prefrontal cortex, specifically the prelimbic area. Building on our previous NIH-funded work which added to an emerging view that this cortical area has importance in reward evaluation and value-based decision-...

Research Terms

<Academic Research Enhancement Awards><Affect><Agonist><American><Area><Award><Behavioral><Brain><Brain Nervous System><Budgets><CD10 Antigens><CTAP><Cell Communication and Signaling><Cell Signaling><Chronic><Cognitive><Common Rat Strains><Computer Models><Computerized Models><Consummatory Behavior><Data Analyses><Data Analysis><Decision Making><Diffusion><Dose><Drug Modulation><Drugs><Electrodes><Encephalon><Enkephalinase><Enkephalins><Ensure><Environment><Evaluation><Exhibits><FBJ osteosarcoma oncogene><FOS gene><Fiber><Funding><G0S7><Goals><Grant><Human><Impairment><Institution><Intracellular Communication and Signaling><Investigators><Link><Maps><Measures><Medial><Medication><Membrane Metalloendopeptidase><Modeling><Modern Man><NIH><Nasal><Nasal Passages Nose><National Institutes of Health><Neprilysin><Neurosciences><Neutral Endopeptidase><Nose><Opiate Receptors><Opiate agonist><Opiate receptor agonist><Opiates><Opioid><Opioid Receptor><Opioid agonist><Opioid receptor agonist><Ph D student><Ph D. student><Ph. D. student><Ph.D student><Ph.D. student><PhD student><PhD. student><Pharmaceutical Preparations><Pharmacology><Photometry><Prefrontal Cortex><Principal Investigator><Process><Protooncogene FOS><Publishing><R15 Mechanism><R15 Program><Rat><Rats Mammals><Rattus><Reporting><Research><Research Assistant><Research Personnel><Researchers><Respiratory System, Nose, Nasal Passages><Rewards><Role><Signal Transduction><Signal Transduction Systems><Signaling><Speed><Stimulus><Students><Study Section><Substance Use Disorder><Testing><Time><Training><United States National Institutes of Health><Universities><Visit><Visual><Work><Writing><antagonism><antagonist><biological signal transduction><c fos><c-fos Gene><c-fos Proto-Oncogenes><career><cognitive control><computational modeling><computational models><computer based models><computerized modeling><connective tissue-activating peptide><data interpretation><design><designing><diffused><diffuses><diffusing><diffusions><doctoral student><drug/agent><experiment><experimental research><experimental study><experiments><feasibility research><high reward><inhibitor><job environment><lectures><multi-electrode arrays><multielectrode arrays><neural><neural mechanism><neuromechanism><opiate use disorder><opioid use disorder><optical sensor><preference><professional atmosphere><recruit><sensor><skills><social role><student research><student-led research><substance use and disorder><undergrad><undergraduate><undergraduate research><undergraduate student><v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog><work atmosphere><work environment><workplace climate><workplace environment>
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Jyotsana Parajuli

UNIVERSITY OF NORTH CAROLINA CHARLOTTE, CHARLOTTE, NC

Exploratory lead · 20/100
Solid budget
Active award
$475,748
FY 2024

Project Title

Development and Initial Validation of a Palliative Care Readiness Tool for Older Adults with Cancer.

Grant Number:

1R15AG081886-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2024

End Date:

5/31/2027

Project Abstract

PROJECT SUMMARY Older adults with cancer suffer from multi-morbidity and age-related physiological changes that can result in high symptom burden, diminished quality of life, and increased complexity of care. While early palliative care (PC) is associated with positive health outcomes such as sympto...

Research Terms

<21+ years old><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><Adult><Adult Human><Aged 65 and Over><Appointment><Area><Assessment instrument><Assessment tool><Awareness><Cancers><Caring><Cessation of life><Chaplain><Chaplaincy><Clinical Nurse Specialists><Clinical Practice Guideline><Clinical Research><Clinical Study><Consensus><Death><Development><Device or Instrument Development><Diagnosis><Discipline of Nursing><Disease><Disorder><EXTMR><Early Intervention><Elderly><Emotional Depression><Ensure><Environment><Ethics><Ethnic Origin><Ethnicity><Extramural><Extramural Activities><Family><Family Care Giver><Family Caregiver><Focus Groups><Funding><Goals><Grant><Health><Health Sciences><Health system><Hearing><Interdisciplinary Research><Interdisciplinary Study><Intervention><Intervention Strategies><Intervention Studies><Interview><Jobs><Jurisprudence><Knowledge><Legal Aspects><Life><Malignant Neoplasms><Malignant Tumor><Measures><Methods><Moods><Multidisciplinary Collaboration><Multidisciplinary Research><NIH><National Institutes of Health><North Carolina><Nurse Clinicians><Nurses><Nursing><Nursing Field><Nursing Profession><Occupations><Oncology><Oncology Cancer><Outcome><Palliative Care><Palliative Therapy><Palliative Treatment><Patients><Perception><Persons><Physicians><Physiologic><Physiological><Population><Preparedness><Principles of law and justice><Process><Professional Positions><Provider><Psychometrics><QOL><Qualifying><Quality of life><Readiness><Recommendation><Religion><Research><Research Design><Research Resources><Research Training><Resources><Rural><Social Workers><Spirituality><Standardization><Structure><Students><Study Type><Survey Instrument><Surveys><Survival Rate><Symptom Burden><Symptoms><Techniques><Testing><United States><United States National Institutes of Health><Universities><Unmarried><Validation><Validity and Reliability><above age 65><adulthood><advanced age><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age associated><age correlated><age dependent><age linked><age of 65 years onward><age related><age specific><aged 65 and greater><aged 65+><aged ≥65><alleviate symptom><ameliorating symptom><assess effectiveness><cancer diagnosis><cancer type><care costs><care services><care systems><clinical practice and guidelines><cognitive interview><comfort care><decrease symptom><depression symptom><depressive><depressive symptoms><determine effectiveness><developmental><device development><effectiveness assessment><effectiveness evaluation><end of life><end of life care><end-of-life><ethical><evaluate effectiveness><examine effectiveness><experience><fewer symptoms><geriatric><graduate student><hands on research><human centered design><human old age (65+)><implementation intervention><improve symptom><improved><innovate><innovation><innovative><insight><instrument><instrument development><intervention research><interventional research><interventional strategy><interventional study><interventions research><low SES><low socio-economic position><low socio-economic status><low socioeconomic position><low socioeconomic status><malignancy><manage symptom><member><multimorbidity><multiple chronic conditions><neoplasm/cancer><nurse><old age><older adult><older adulthood><over 65 years><pain relief><physical symptom><prevent><preventing><psychologic><psychological><psychological symptom><racial diversity><racial minority><racially diverse><reduce symptoms><relieve pain><relieves symptoms><religious><response><rural area><rural location><rural region><senior citizen><social><stem><study design><symptom alleviation><symptom improvement><symptom management><symptom reduction><symptom relief><symptomatic improvement><tool><tool development><undergrad><undergraduate><undergraduate student><uptake><urban residence><validations><≥65 years>
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Salman Sohrabi

UNIVERSITY OF TEXAS ARLINGTON, ARLINGTON, TX

Exploratory lead · 20/100
Solid budget
Active award
$472,793
FY 2025

Project Title

Decoupling reproductive and somatic aging using novel C. elegans technology

Grant Number:

1R15AG089221-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2025

End Date:

8/31/2028

Project Abstract

ABSTRACT As women age, the risk of infertility and recurrent pregnancy loss rises; however, the molecular mechanisms driving the onset and progression of reproductive senescence remain largely unexplored. A key challenge is that reproductive aging is largely coupled with the decline of somatic healt...

Research Terms

<21+ years old><AI based><Address><Adult><Adult Human><Age><Aging><Animal Model><Animal Models and Related Studies><Animals><Assay><Automobile Driving><Autophagocytosis><Bioassay><Biologic Models><Biological><Biological Assay><Biological Models><Biology><Birth Defects><C elegans><C. elegans><C.elegans><Caenorhabditis elegans><Cannot achieve a pregnancy><Cell Communication and Signaling><Cell Signaling><Cessation of life><Collaborations><Communities><Complex><Computers><Congenital Abnormality><Congenital Anatomical Abnormality><Congenital Defects><Congenital Deformity><Congenital Malformation><Coupled><Death><Development><Device Designs><Devices><Difficulty conceiving><Down-Regulation><Egg Yolk Proteins><Engineering><Event><FK506 Binding Protein 12-Rapamycin Associated Protein 1><FKBP12 Rapamycin Complex Associated Protein 1><FRAP1><FRAP1 gene><FRAP2><Failure><Food><GeneHomolog><Genes><Genetic><Genomics><Goals><Grant><Health><Homolog><Homologous Gene><Homologue><Human><Human Biology><Humulin R><IGF-1><IGF-I><IGF-I-SmC><Individual><Infertility><Insulin><Insulin-Like Growth Factor 1><Insulin-Like Growth Factor I><Insulin-Like Somatomedin Peptide I><Interdisciplinary Research><Interdisciplinary Study><Intervention><Intracellular Communication and Signaling><Kinases><Length of Life><Link><Longevity><Machine Learning><Manuals><Mechanistic Target of Rapamycin><Menopause><Mice><Mice Mammals><Microfluidics><Miscarriage><Mitochondria><Model System><Modeling><Modern Man><Molecular><Monitor><Multidisciplinary Collaboration><Multidisciplinary Research><Murine><Mus><Nematoda><Nematodes><Novolin R><Optics><Ovarian><Partner in relationship><Pathway interactions><Phenotype><Phosphotransferase Gene><Phosphotransferases><Pregnancy loss><Primates><Primates Mammals><Process><Production><Proteins><RAFT1><Recurrence><Recurrent><Regular Insulin><Regulatory Pathway><Reproduction><Reproductive Biology><Reproductive Health><Reproductive Medicine><Research><Risk><Role><SGK1 protein><Scientist><Serum-glucocorticoid-regulated kinase 1><Sgk protein><Sight><Signal Transduction><Signal Transduction Systems><Signaling><Somatomedin C><Source><Spontaneous abortion><Students><System><Techniques><Technology><Temperature><Testing><Training><Translations><Transphosphorylases><Upregulation><Vision><Woman><Yolk Proteins><adulthood><age associated decline><age dependent decline><age related decline><ages><artificial intelligence based><autophagy><biologic><biological signal transduction><computer science><cost><decline with age><design><designing><detection of nutrient><developmental><driving><egg quality><experience><experiment><experimental research><experimental study><experiments><fat metabolism><fertility cessation><fertility loss><graduate student><hatching><implantation><infertile><innovate><innovation><innovative><insight><intervention enhancing longevity><intervention to extend lifespan><intervention to improve lifespan><intervention to increase longevity><intervention to prolong lifespan><intervention to promote longevity><life span><lifespan><lifespan extending intervention><lifespan extending therapies><lifespan improving intervention><lifespan increasing intervention><lifespan increasing therapies><lifespan intervention><lifespan prolonging interventions><lifespan promoting intervention><lipid metabolism><longevity boosting intervention><longevity extending intervention><longevity intervention><longevity promoting intervention><longevity therapy><longevity treatment><mTOR><machine based learning><machine learned algorithm><machine learning algorithm><machine learning based algorithm><mammalian target of rapamycin><mate><mid life><mid-life><middle age><middle aged><midlife><millimeter><mitochondrial><model of animal><mortality><mutant><new technology><novel><novel technologies><nutrient sensing><oocyte quality><optical><pathway><perception of nutrients><reproductive><reproductive aging><reproductive cell senescence><reproductive fitness><reproductive longevity><reproductive senescence><roundworm><serum and glucocorticoid-regulated kinase><social role><strategy to enhance longevity><strategy to promote longevity><therapeutic target><tool><trait><translation><undergrad><undergraduate><undergraduate student><visual function><µfluidic>
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Yanhua Xie

NEW YORK INST OF TECHNOLOGY, OLD WESTBURY, NY

Exploratory lead · 20/100
Solid budget
Active award
$472,592
FY 2025

Project Title

RgIA5474 as a Novel α9α10 Nicotinic Acetylcholine Receptor Antagonist to Treat Migraine

Grant Number:

1R15NS143081-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2025

End Date:

7/31/2028

Project Abstract

Project Summary Treatment of episodic migraine relies on acute therapies that are often not effective in as many as half of the patients. We wish to test the relevance of α9α10 nicotinic acetylcholine receptors (nAChRs) as a new target for the treatment of migraine. We hypothesize that RgIA5474, a p...

Research Terms

<(TNF)-α><Academic Research Enhancement Awards><Acute><Adrenal Glands><Adrenal Hormone><Adrenal Medulla><Adrenal hormone preparation><Adrenals><Affect><Affinity><Animals><Autonomic nervous system><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BBB penetration><BCDF><BSF-2><BSF2><Behavior><Behavioral><Biological Response Modifiers><Biomodulators><Blood><Blood Plasma><Blood Reticuloendothelial System><CBA/CaJ Mouse><CGRP Receptors><CNS Nervous System><Cachectin><Calcitonin Gene-Related Peptide><Calcitonin-Gene Related Peptide Receptor><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Catecholamines><Cell Body><Cells><Cellular Stress><Cellular Stress Response><Central Nervous System><Cephalic><Chromaffin Cells><Clinical><Common Rat Strains><Cranial><Cranial Nerve V><Data><Development><Disabling><Disease><Disorder><Dose><Dura><Dura Mater><Endocrine Gland Secretion><Face><Female><Fiber><Fifth Cranial Nerve><Funding><Future><Ganglia><Gasser's Ganglion><Gasserian Ganglion><Generations><HPGF><Heart Vascular><Hepatocyte-Stimulating Factor><Hormones><Human><Hybridoma Growth Factor><Hypersensitivity><IFN-beta 2><IFNB2><IL-6><IL6 Protein><Immune><Immune Mediators><Immune Mediators/Modulators><Immunes><Inflammation><Inflammation Mediators><Inflammatory><Infusion><Infusion procedures><Inner Hair Cells><Inner ear hair cells><Interleukin-6><Internal Ear><KO mice><Knock-out Mice><Knockout Mice><Labyrinth><Ligands><Light><MD students><MGI-2><Macrophage-Derived TNF><Measures><Mediating><Mediator><Medical><Medical Students><Medicine><Meninges><Mice><Mice Mammals><Migraine><Migraine Headache><Mission><Modeling><Modern Man><Monocyte-Derived TNF><Murine><Mus><Myeloid Differentiation-Inducing Protein><Nature><Nerve Cells><Nerve Unit><Nervus Trigeminus><Neural Cell><Neural Ganglion><Neuraxis><Neurocyte><Neurons><Neuropeptides><Nicotinic Acetylcholine Receptors><Nicotinic Receptors><Nociceptors><Nucleus of the Fifth Nerve><Null Mouse><Output><PACAP><PACAP-38><PACAP38><Pain><Painful><Pathology><Patients><Peptides><Peripheral><Permeability><Persons><Photoradiation><Placebos><Plasma><Plasma Serum><Plasmacytoma Growth Factor><Probability><Process><R15 Mechanism><R15 Program><Rat><Rats Mammals><Rattus><Reticuloendothelial System, Serum, Plasma><Rodent><Rodentia><Rodents Mammals><Science><Semilunar Ganglion><Sensory><Sham Treatment><Snails><Stimulus><Stress><Structure of trigeminal ganglion><Students><Sumatriptan><Sympathins><Symptoms><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Tactile><Testing><Therapeutic><Therapeutic Hormone><Time><Toxic effect><Toxicities><Toxin><Trigeminal Ganglias><Trigeminal Ganglion><Trigeminal Nerve><Trigeminal Nuclei><Trigeminal System><Trigeminal nerve structure><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Validation><Woman><adrenal gland medulla><allodynia><analog><antagonism><antagonist><associated symptom><blood-brain barrier penetration><bloodbrain barrier penetration><career><cell stress><circulatory system><co-morbid symptom><co-occuring symptom><comorbid symptom><concurrent symptom><cooccuring symptom><cutaneous allodynia><cytokine><determine efficacy><developmental><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><efficacy testing><evaluate efficacy><examine efficacy><faces><facial><female patients><graduate student><improved><inflammatory mediator><infusions><inner ear><interferon beta 2><male><marine><marine environment><medical school students><men><meninge><migraine therapy><migraine treatment><mouse model><murine model><neurochemical><neurochemistry><neuronal><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><nociceptive neurons><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pain relief><pain-sensing neurons><pain-sensing sensory neurons><pain-sensing somatosensory neurons><patients being female><patients being women><patients who are female><pituitary adenylate cyclase activating peptide><pituitary adenylate cyclase activating polypeptide><pituitary adenylate cyclase activating polypeptide-38><polypeptide><prototype><relieve pain><sex><sex dimorphism><sexual dimorphism><sexually dimorphic><sham therapy><side effect><spontaneous pain><suprarenal gland><symptom association><symptom comorbidity><training opportunity><translational opportunities><translational potential><trigeminal><triptans><undergrad><undergraduate><undergraduate student><validations><women patients><♀><♂>
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Liliya Vugmeyster

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 20/100
Solid budget
Active award
$466,972
FY 2025

Project Title

Internal water dynamics in hydration shells of amyloid-beta species

Grant Number:

1R15GM157635-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2025

End Date:

8/31/2028

Project Abstract

One of the hallmarks of Alzheimer’s disease is the presence of neurotoxic amyloid-β (Aβ) deposits in brain tissue. All Aβ species from oligomers to fibrils exist in a dynamic equilibrium, which is believed to trigger a pathological cascade implicating multiple aggregation-prone proteins. Mechanisms ...

Research Terms

<AD dementia><Adopted><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimers Dementia><Amyloid><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid Substance><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Award><Aβ><Behavior><Beta Sheet><Binding><Cell Nucleus><Cell membrane><Chemicals><Collaborations><Colorado><Complex><Cytoplasmic Membrane><DNA mutation><Deposit><Deposition><Deuterium><Disease><Disorder><Equilibrium><Funding><Genetic Change><Genetic defect><Genetic mutation><Glass><Goals><H2 isotope><Hydration><Hydration status><Hydrogen Oxide><Hydrophobicity><Incidence><Investigation><Investigators><Iowa><Kinetics><Laboratories><Lipids><Liquid substance><Lytotoxicity><Membrane><Methodology><Modeling><Modification><Molecular Interaction><Mutation><N-terminal><NH2-terminal><NIH><National Institutes of Health><Nucleus><O element><O2 element><Onset of illness><Oxygen><Pathologic><Peptides><Phosphorylation><Plasma Membrane><Polymorph><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Preparation><Primary Senile Degenerative Dementia><Property><Protein Modification><Protein Phosphorylation><Proteins><Pyroglutamate><Research Personnel><Researchers><Roentgen Rays><Role><SSNMR><Site><Structure><Surface><System><Temperature><Thermodynamic><Thermodynamics><Time><United States National Institutes of Health><Universities><Variant><Variation><Water><Work><X ray diffraction><X ray diffraction analysis><X-Radiation><X-Ray Radiation><X-ray><Xray><Xray diffraction><a beta peptide><abeta><abeta accumulation><abeta aggregation><amyloid beta><amyloid beta accumulation><amyloid beta aggregation><amyloid β accumulation><amyloid β aggregation><amyloid-b protein><aβ accumulation><aβ aggregation><balance><balance function><beta amyloid fibril><beta pleated sheet><biomedical profession><brain tissue><cold temperature><cytotoxicity><disease onset><disorder onset><flexibility><flexible><fluid><genome mutation><in vivo><liquid><low temperature><macromolecule><membrane structure><monolayer><mutant><neurotoxic><new approaches><novel approaches><novel strategies><novel strategy><phenomenological models><phenomenology><plasmalemma><preparations><primary degenerative dementia><protein structure><protein structures><proteins structure><senile dementia of the Alzheimer type><social role><solid state NMR><solid state nuclear magnetic resonance><soluble amyloid precursor protein><undergrad><undergraduate><undergraduate student><β-Sheet><β-pleated sheet>
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In Hong Yang

UNIVERSITY OF NORTH CAROLINA CHARLOTTE, CHARLOTTE, NC

Exploratory lead · 20/100
Solid budget
Active award
$462,000
FY 2024

Project Title

Neuroprotection for chemotherapy induced peripheral neuropathy

Grant Number:

1R15CA290570-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2024

End Date:

2/28/2027

Project Abstract

Chemotherapy induced peripheral neuropathy (CIPN) poses a major clinical problem due to its oftentimes dose- limiting side effects associated with many commonly employed anti-cancer chemotherapy drugs. The onset of CIPN severely impacts the quality of life of patients, leading to dosages reductions,...

Research Terms

<Adrenal Cortex Hormones><Affect><Afferent Neurons><Affinity><Anti-Cancer Agents><Antineoplastic Agents><Antineoplastic Drugs><Antineoplastics><Anzatax><Asotax><Autoregulation><Axon><Axonal Transport><Axoplasmic Transport><Biogenesis><Bladder><Bladder Urinary System><Breast><Bristaxol><Burning Pain><Cancer Drug><Cancer Treatment><Cancers><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell membrane><Cells><Chemotherapy Protocol><Chemotherapy Regimen><Chemotherapy-Oncologic Procedure><Chemotherapy-induced peripheral neuropathy><Clinical><Combination Chemotherapy Regimen><Complement><Complement Proteins><Corticoids><Corticosteroids><Cytoplasmic Membrane><Data><Development><Development and Research><Distal><Distress><Dose Limiting><Drug Screening><Drug Utilization><Drugs><Dysfunction><Endoplasmic Reticulum><Energy Supply><Engineering><Equilibrium><Ergastoplasm><Esophagus><Event><FDA approved><Female><Fluocinolone Acetonide><Fluortriamcinolone Acetonide><Functional disorder><Functional impairment><Glucocorticoid Receptor><Glucocorticoids><Golgi><Golgi Apparatus><Golgi Complex><Growth Cones><Hand><Health><Homeostasis><In Vitro><Incidence><Interdisciplinary Research><Interdisciplinary Study><Intervention><Intervention Strategies><Intracellular Communication and Signaling><Ion Channel><Ionic Channels><Label><Loss of Sensation><Lysosomes><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Mediating><Medication><Membrane Channels><Methods><Microfluidics><Mitochondria><Movement><Multidisciplinary Collaboration><Multidisciplinary Research><NSCLC><NSCLC - Non-Small Cell Lung Cancer><Neoplastic Disease Chemotherapeutic Agents><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neuroprotectants><Neuroprotective Agents><Neuroprotective Drugs><Neurosciences><Non-Small Cell Lung Cancer><Non-Small-Cell Lung Carcinoma><North Carolina><Numbness><Organelles><Origin of Life><Ovarian><PNS Diseases><Paclitaxel><Paclitaxel (Taxol)><Pain><Painful><Pathogenesis><Patients><Peripheral><Peripheral Nerve Diseases><Peripheral Nervous System Diseases><Peripheral Nervous System Disorders><Peripheral Neuropathy><Pharmaceutical Preparations><Physiological Homeostasis><Physiopathology><Plasma Membrane><Play><Population><Position><Positioning Attribute><Praxel><Production><Prostate><Prostate Gland><Prostatic Gland><Publications><QOL><Quality of life><Quimioterapia><R & D><R&D><R-Series Research Projects><R01 Mechanism><R01 Program><Receptor Protein><Reporting><Research><Research Grants><Research Project Grants><Research Projects><Role><Sampling><Scientific Publication><Sensory Neurons><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Skin><Spatial Distribution><Students><Symptoms><System><Taxol><Taxol A><Taxol Konzentrat><Therapeutic><Time><Tumor-Specific Treatment Agents><Underrepresented Ethnic Minority><Underrepresented Minority><Universities><anti-cancer><anti-cancer drug><anti-cancer therapy><axon growth><axon regeneration><axonal degeneration><axonal growth><axonal regeneration><balance><balance function><biological signal transduction><body movement><cancer chemotherapy><cancer therapy><cancer-directed therapy><chemotherapy><complementation><degenerative axon><design><designing><developmental><dosage><drug/agent><experience><foot><hands><high-throughput drug screening><image-based method><imaging method><imaging modality><in vivo><innovate><innovation><innovative><interventional strategy><malignancy><mitochondrial><neoplasm/cancer><neuronal><neuropathic pain><neuroprotection><neuroprotective><pain sensation><painful neuropathy><painful sensation><pathophysiology><pharmacologic><plasmalemma><prevent><preventing><receptor><recruit><research and development><retrograde transport><side effect><social role><therapeutic candidate><trafficking><treatment effect><under-representation of minorities><under-represented minority><undergrad><undergraduate><undergraduate student><underrepresentation of minorities><urinary bladder><µfluidic>
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Jennifer Hahn

UNIVERSITY OF CALIFORNIA, MERCED, MERCED, CA

Exploratory lead · 20/100
Solid budget
Active award
$461,457
FY 2023

Project Title

Circadian Rhythms in Human Milk Cortisol: An Examination of Maternal and Environmental Regulators

Grant Number:

1R15HD111890-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/4/2023

End Date:

8/31/2026

Project Abstract

PROJECT SUMMARY The development of healthy circadian biology is vital to infant health—infants with dysregulated circadian biology are at higher risk of sleep disorders, digestive issues, and neurocognitive deficits. One recently identified factor thought to entrain infant circadian biology is human...

Research Terms

<Aeroseb-HC><Animals><Award><Biological Markers><Body Tissues><Brain><Brain Nervous System><Breast Feeding><Breast Milk><Breast fed><Breast fed infant><Breastfed><Breastfed infant><Breastfeeding><Breastmilk><California><Cetacort><Circadian Rhythms><Circulation><Cort-Dome><Cortef><Cortenema><Cortisol><Cortispray><Cortril><Cyclicity><Dairying><Dermacort><Development><Digestion><Eldecort><Electronics><Emotional Depression><Encephalon><Endocrine Gland Secretion><Environmental Factor><Environmental Risk Factor><Exclusive Breast Feeding><Exclusive Breastfeeding><Exhibits><Exposure to><Feeding Patterns><First Generation College Students><First Generation College graduates><First Generation Students><Funding><Generalized Growth><Genetic><Goals><Growth><Health><Height><Hispanic><Home><Hormonal><Hormones><Hour><Human><Human Milk><Human Mother's Milk><Hydrocortisone><Hydrocortone><Hytone><IQ Deficit><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologics><Infant><Infant Development><Infant Health><Interdisciplinary Research><Interdisciplinary Study><Intermediary Metabolism><Intervention><Intervention Strategies><Investigators><Life Style><Lifestyle><Light><Mammary Gland Milk><Measures><Mental Depression><Metabolic Processes><Metabolism><Milk><Mission><Modeling><Modern Man><Modernization><Mother's Milk><Mothers><Multidisciplinary Collaboration><Multidisciplinary Research><NICHD><NIH><National Institute of Child Health and Human Development><National Institute of Children's Health and Human Development><National Institutes of Health><Neurocognitive Deficit><Non obese><Nonobese><Nutracort><Nutritional><Nyctohemeral Rhythm><Obesity><Outcome><Pattern><Periodicity><Peripheral><Persons><Photoradiation><Play><Proctocort><Research><Research Personnel><Research Priority><Research Training><Researchers><Rhythmicity><Rodent><Rodentia><Rodents Mammals><Role><Sampling><Sleep><Sleep Disorders><Sleep Wake Cycle><Sleep disturbances><Stress><System><Systems Biology><Testing><Therapeutic Hormone><Tissue Growth><Tissues><Training><Twenty-Four Hour Rhythm><United States National Institutes of Health><Universities><Variant><Variation><Weight><aberrant sleep><acute stress><adiposity><bio-markers><biologic marker><biomarker><breast feeding infant><breastfeeding infant><chronic symptom><circadian><circadian biology><circadian clock><circadian pacemaker><circadian process><corpulence><daily biorhythm><depression><depression symptom><depressive><depressive symptoms><developmental><diaries><disrupted sleep><disturbed sleep><electronic><electronic device><environmental risk><exclusively breast fed><exclusively breast feeding><exclusively breastfed><exclusively breastfeeding><experience><high risk><homes><impaired sleep><improved><intelligence quotient deficit><interventional strategy><irregular sleep><life-style factor><lifestyle factors><mammary><maternal milk><milk production><neurocognitive decline><neurocognitive impairment><next generation><novel><nutritious><ontogeny><persistent symptom><primary outcome><produce milk><recruit><respiratory><sleep diseases><sleep disruption><sleep dysfunction><sleep dysregulation><sleep illness><sleep pattern><sleep problem><social role><stress symptom><suprachiasmatic nucleus><under-served student><undergrad><undergraduate><undergraduate student><underserved students><virtual><weights>
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Xuanmao Chen

UNIVERSITY OF NEW HAMPSHIRE, DURHAM, NH

Exploratory lead · 20/100
Solid budget
Active award
$460,500
FY 2025

Project Title

cAMP signaling and three activity states of hippocampal neurons

Grant Number:

2R15MH125305-02

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2021

End Date:

11/10/2027

Project Abstract

Project Summary Memory formation is a fundamental biological process that enables the brain to acquire and retain experiences and knowledge. Impaired learning and memory formation affect our cognitive capacity and cause various cognitive dysfunction-related disorders, including dementia, schizophren...

Research Terms

<3'5'-cyclic ester of AMP><3,5 cyclic AMP synthetase><AMPA Receptors><Abscission><Academic Research Enhancement Awards><Adenosine Cyclic 3',5'-Monophosphate><Adenosine Cyclic Monophosphate><Adenosine, cyclic 3',5'-(hydrogen phosphate)><Adenyl Cyclase><Adenylate Cyclase><Adenylyl Cyclase><Affect><Amentia><Ammon Horn><Association Learning><Associative Learning><Behavioral><Biological Function><Biological Process><Brain><Brain Nervous System><CNS Nervous System><Calcium><Cations><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Central Nervous System><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Complement><Complement Proteins><Connectionist Models><Cornu Ammonis><Cyclic AMP><Data><Dementia><Development><Disease><Disorder><Dissociation><Disturbance in cognition><Drug Targeting><Dysfunction><Eligibility><Eligibility Determination><Encephalon><Esthesia><Excision><Exhibits><Extirpation><Fore-Brain><Forebrain><Functional disorder><Glutamates><Goals><Hippocampus><Image><Impaired cognition><Impairment><In vivo two-photon calcium imaging><Intracellular Communication and Signaling><KO mice><Ketamine><Knock-out Mice><Knockout Mice><Knowledge><L-Glutamate><Lead><Learning><Ligand Binding><Long-Term Potentiation><MK 801><MK801><Magnesium><Maps><Mediating><Membrane><Memory><Mental disorders><Mental health disorders><Methods><Mg element><Mice><Mice Mammals><Modeling><Monitor><Murine><Mus><N-Methyl-D-Aspartate Receptors><N-Methylaspartate Receptors><NMDA Receptor-Ionophore Complex><NMDA Receptors><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neural Development><Neural Network Models><Neural Network Simulation><Neural Transmission><Neuraxis><Neurocyte><Neuronal Transmission><Neurons><Neurosciences Research><New Hampshire><Null Mouse><PTSD><Pavlovian conditioning><Pb element><Perception><Perceptrons><Permeability><Phase><Physiology><Physiopathology><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Posttraumatic Neuroses><Prosencephalon><Protocol Screening><Psychiatric Disease><Psychiatric Disorder><Psychoses><R15 Mechanism><R15 Program><Receptor Protein><Removal><Research><Role><Schizophrenia><Schizophrenic Disorders><Sensation><Signal Transduction><Signal Transduction Systems><Signaling><Surgical Removal><Synapses><Synaptic><Synaptic Transmission><Synaptic plasticity><Time><Transgenic Organisms><Universities><Work><adenosine 3'5' monophosphate><associative conditioning><axon signaling><axon-glial signaling><axonal signaling><biological signal transduction><cAMP><classical conditioning><cognitive capacity><cognitive dysfunction><cognitive loss><cohort><complementation><conditioned fear><conditioning><dementia praecox><developmental><environment enrichment><environment enrichment for laboratory animals><environmental enrichment><environmental enrichment for laboratory animals><experience><fear conditioning><feeding><glia signaling><glial signaling><glutamatergic><heavy metal Pb><heavy metal lead><hippocampal><image-based method><imaging><imaging method><imaging modality><in vivo><in vivo calcium imaging><membrane structure><memory retrieval><mental illness><nerve signaling><neural><neural signaling><neurodevelopment><neuronal><neuronal signaling><neurotransmission><novel><overexpress><overexpression><pathophysiology><post-trauma stress disorder><posttrauma stress disorder><psychiatric illness><psychological disorder><receptor><recruit><resection><schizophrenic><simulation><social role><synapse><transgenic><traumatic neurosis><undergrad><undergraduate><undergraduate student><voltage>
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Arsalan Mirjafari

COLLEGE AT OSWEGO, OSWEGO, NY

Exploratory lead · 20/100
Solid budget
Active award
$459,551
FY 2024

Project Title

Enhancing Vaccine Thermostability with Natural Deep Eutectic Solvents

Grant Number:

1R15GM153057-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2027

Project Abstract

PROJECT SUMMARY The poor thermostability of vaccines is the most notable factor for their inequitable global distribution. The cold chain system imposes a substantial barrier for equitable global access to safe and potent vaccines. To eliminate or improve this vaccine coverage gap, minimizing the co...

Research Terms

<2019-nCoV vaccine><Academic Research Enhancement Awards><Acceleration><Acids><Adenoviridae><Adenoviruses><Ammonium><Anions><Assay><Binding><Bioassay><Biological Assay><CD/ORD Spectroscopy><COVID-19 prevention><COVID-19 vaccine><Calorimetric Differential Thermal Analysis><Capsid Proteins><Cations><Cessation of life><Characteristics><Chemicals><Circular Dichroism Spectroscopy><Coat Proteins><Cold Chains><Community Developments><Complex><Death><Development><Differential Scanning Calorimetry><Disease Outbreaks><Double Stranded DNA Virus><Double-Stranded DNA><Environment><Equity><Exposure to><FDA approved><Fluorides><Formulation><Generations><Goals><Grant><H-bond><Hydration><Hydration status><Hydrogen Bonding><Hydrogen Oxide><Inequity><Institution><Instruction><Interdisciplinary Research><Interdisciplinary Study><Ions><LMIC><Life><Lipid Bilayers><Lipids><Liquid substance><Logistics><Mentors><Methods><Modeling><Molecular><Molecular Interaction><Monitor><Morphology><Multidisciplinary Collaboration><Multidisciplinary Research><Natural Resources><Nature><Non-Polyadenylated RNA><Outbreaks><Outcome><Pattern><Persons><Process><Property><Proteins><Protocol><Protocols documentation><Quantitative RTPCR><Quantitative Reverse Transcriptase PCR><R15 Mechanism><R15 Program><RNA><RNA Gene Products><RNA Viruses><Recovery><Refrigeration><Research><Research Resources><Resources><Ribonucleic Acid><Rural Community><SARS-CoV-2 vaccine><SARS-coronavirus-2 vaccine><Sampling><Scanning><Series><Severe Acute Respiratory Syndrome CoV 2 vaccine><Severe acute respiratory syndrome coronavirus 2 vaccine><Single Crystal Diffraction><Solvents><Source><Structure><System><Techniques><Technology><Temperature><Time><Toxic effect><Toxicities><Transportation><URM student><Universities><Vaccination><Vaccines><Variant><Variation><Viral><Viral Coat Proteins><Viral Gene Products><Viral Gene Proteins><Viral Genome><Viral Outer Coat Protein><Viral Proteins><Virus><Water><Woman><Work><X Ray Crystallographies><X-Ray Crystallography><X-Ray Diffraction Crystallography><X-Ray/Neutron Crystallography><Xray Crystallography><Yellow fever virus><accelerated aging><accelerated biological age><accelerated biological aging><access to vaccination><access to vaccines><age acceleration><analytical method><base><bases><biocompatibility><biomaterial compatibility><climate change><climatic changes><coronavirus disease 2019 prevention><coronavirus disease 2019 vaccine><coronavirus disease-19 prevention><coronavirus disease-19 vaccine><cost><cost effective><deploy vaccines><design><designing><developmental><distribute vaccines><ds-DNA><dsDNA><dsDNA Virus><economic cost><epidemic concern><epidemic potential><epidemic risk><epidemic threat><flexibility><flexible><fluid><genome integrity><genomic integrity><global climate change><global health><impoverished communities><improved><innovate><innovation><innovative><intermolecular interaction><light scattering><lipid bilayer membrane><liquid><low and middle-income countries><meeting><meetings><melting><nCoV vaccine><nCoV-19 vaccine><nCoV19 vaccine><novel><nucleic acid stability><pandemic><pandemic disease><particle><pathogen><polyol><poor communities><poverty communities><preservation><prevent><prevent COVID-19><prevent coronavirus disease 2019><preventing><qRTPCR><rational design><remote communities><simulation><sugar><thermolability><thermostability><tool><undergrad><undergraduate><undergraduate student><underrepresented minority student><vaccination access><vaccination availability><vaccine access><vaccine against 2019-nCov><vaccine against COVID-19><vaccine against SARS-CoV-2><vaccine against SARS-coronavirus-2><vaccine against Severe Acute Respiratory Syndrome CoV 2><vaccine against Severe acute respiratory syndrome coronavirus 2><vaccine availability><vaccine candidate><vaccine candidates against SARS-CoV-2><vaccine deployment><vaccine distribution><vaccine for novel coronavirus><vaccine platform><vaccine roll-out><vaccine rollout><vaccines preventing COVID><vaccines to prevent COVID><virus genome><virus protein>
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Michael R. Nichols

UNIVERSITY OF MISSOURI-ST. LOUIS, SAINT LOUIS, MO

Exploratory lead · 20/100
Solid budget
Active award
$459,279
FY 2023

Project Title

Mechanisms of NLRP3 inflammasome activation

Grant Number:

1R15GM152964-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/20/2023

End Date:

8/31/2026

Project Abstract

PROJECT SUMMARY/ABSTRACT An important component of the mammalian innate immune system is the NLRP3 inflammasome, an intracellular complex of three proteins that, upon activation, produces the cytokine interleukin-1β. Activation of the NLRP3 complex can occur via internalization of a growing number o...

Research Terms

<AD dementia><Academic Research Enhancement Awards><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimers Dementia><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Apoptosis-Related Cysteine Protease Caspase 1><Aβ><Beta Proprotein Interleukin 1><Binding><Biochemical><Biophysics><CASP-1><CASP1><CASP1 gene><Cardiac Diseases><Cardiac Disorders><Caspase-1><Caspase-1 Gene><Catalysis><Cell Body><Cells><Complex><Confocal Microscopy><Data><Degenerative Neurologic Diseases><Degenerative Neurologic Disorders><Disease><Disorder><Education and Training><Elements><Enzyme Gene><Enzymes><Future><Heart Diseases><Hortega cell><Human><ICE Protease><IL-1 beta><IL-1 beta Convertase><IL-1 beta-Converting Enzyme><IL-1 β><IL-1-b><IL-1BC><IL-1b Converting Enzyme><IL-1β><IL1-Beta><IL1-β><IL1B Protein><IL1B-Convertase><IL1BC><IL1BCE><IL1F2><IL1β><In Vitro><Inflammasome><Inflammatory><Innate Immune System><Institution><Interleukin 1-B Converting Enzyme><Interleukin 1-Beta Convertase><Interleukin 1beta><Interleukin-1 Beta Converting Enzyme><Interleukin-1 Converting Enzyme><Interleukin-1 beta><Interleukin-1β><Investigation><Knowledge><Lead><Link><Medical><Microglia><Modern Man><Molecular><Molecular Configuration><Molecular Conformation><Molecular Interaction><Molecular Stereochemistry><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Pattern><Pb element><Preinterleukin 1 Beta><Primary Senile Degenerative Dementia><Process><Production><Proteins><R15 Mechanism><R15 Program><Recombinants><Regulation><Research><Role><Students><System><Testing><Therapeutic><Training and Education><Transfection><Viral><Work><a beta peptide><abeta><amyloid beta><amyloid-b protein><beta amyloid fibril><biophysical foundation><biophysical principles><biophysical sciences><conformation><conformational><conformational state><conformationally><conformations><cytokine><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><experience><gitter cell><heart disorder><heavy metal Pb><heavy metal lead><improved><interest><mesoglia><microglial cell><microgliocyte><neurodegenerative illness><pathogen><perivascular glial cell><primary degenerative dementia><research study><response><senile dementia of the Alzheimer type><social role><soluble amyloid precursor protein><undergrad><undergraduate><undergraduate student>
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Huai Deng

UNIVERSITY OF MINNESOTA DULUTH, DULUTH, MN

Exploratory lead · 20/100
Solid budget
Active award
$459,139
FY 2023

Project Title

Epigenetic regulation of chromatin by the Keap1-Nrf2 xenobiotic response signaling in Drosophila

Grant Number:

2R15GM128143-02

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2018

End Date:

8/31/2026

Project Abstract

Epigenetic regulation of chromatin by the Keap1-Nrf2 xenobiotic response signaling in Drosophila ABSTRACT Conserved oxidative and xenobiotic response factors protect cells from damages caused by internal or external toxins. How these factors mediate the adaptation to constant environmental toxins i...

Research Terms

<Abscission><Actins><Antioxidants><Architecture><Assay><Binding><Bioassay><Biologic Assays><Biologic Sciences><Biological><Biological Assay><Biological Function><Biological Process><Biological Sciences><Biology><Biomedical Research><Bioscience><Cancers><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cell Body><Cell Communication and Signaling><Cell Nucleus><Cell Protection><Cell Signaling><Cells><Cellular injury><Chromatin><Chromatin Remodeling Complex><Chromatin Remodeling Factor><Chromatin Structure><Cytoprotection><DNA Molecular Biology><Defect><Development><Developmental Gene><Disease><Disorder><Drosophila><Drosophila genus><Drug Metabolic Detoxication><Drug Metabolic Detoxification><Engineering / Architecture><Environment><Environmental Toxin><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Euchromatin><Excision><Exposure to><Expression Signature><Extirpation><Gene Expression><Gene Expression Profile><Gene Transcription><Genes><Genetic><Genetic Transcription><Genetic analyses><Genetics-Mutagenesis><Goals><Grant><Health><Heart Vascular><Heterochromatin><Histone Code><Homologous Protein><Human><Image><In Vitro><Inflammation><Intracellular Communication and Signaling><Laboratories><Lamin B><Lamin Type B><Lamins><Learning><Life Sciences><Malignant Neoplasms><Malignant Tumor><Mediating><Metabolic Drug Detoxications><Metabolism of Toxic Agents><Modeling><Modern Man><Modification><Molecular><Molecular Analysis><Molecular Biology><Molecular Interaction><Mutagenesis><Mutagenesis Molecular Biology><NURF><Nucleosome Remodeling Factor><Nucleus><Oxidation-Reduction><Pathogenesis><Pathogenicity><Pathologic><Pathway interactions><Protein Family><Protein Homolog><ProteinHomolog><Proteins><RNA Expression><Redox><Regulation><Removal><Research><Respiratory Disease><Respiratory System Disease><Respiratory System Disorder><Role><Science><Shapes><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Stimulus><Stress><Students><Surgical Removal><Techniques><Testing><Toxic Environmental Agents><Toxic Environmental Substances><Toxin><Transcription><Type V IF Protein><Work><Xenobiotics><anti-oxidant><biologic><biological signal transduction><cell damage><cell injury><cellular damage><chromatin modifier><chromatin remodeling><circulatory system><cytoprotective><damage to cells><detoxification><develop therapy><developmental><environmental change><environmental toxicant><epigenetic regulation><epigenetically><epigenome><experience><fluorescence imaging><fluorescent imaging><fruit fly><gene expression pattern><gene expression signature><genetic analysis><human disease><imaging><improved><in vivo><injury to cells><insight><intervention development><malignancy><mutant><neoplasm/cancer><novel><oxidation reduction reaction><pathway><programs><promoter><promotor><resection><response><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapy development><transcriptional profile><transcriptional signature><treatment development><undergrad><undergraduate><undergraduate education><undergraduate research><undergraduate research experience><undergraduate research opportunities><undergraduate research programs><undergraduate student>
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Melissa Taft Manners

ROWAN UNIVERSITY, GLASSBORO, NJ

Exploratory lead · 20/100
Solid budget
Active award
$457,983
FY 2023

Project Title

Exercise and TLR: Mechanisms underlying resilience to chronic stress

Grant Number:

1R15MH130900-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2023

End Date:

8/31/2026

Project Abstract

Stress is an inevitable and normal part of daily life, and activation of the stress response is vital for survival. However, chronic stress can have a negative impact on mental health and wellbeing, and lead to mental illness in susceptible individuals. We do not fully understand how chronic stress ...

Research Terms

<3' Untranslated Regions><3'UTR><Academic Research Enhancement Awards><Affect><Ammon Horn><Antidepressant Agent><Antidepressant Drugs><Antidepressants><Antidepressive Agents><Anxiety Disorders><Assay><Behavior><Behavioral><Binding><Bioassay><Biologic Assays><Biological Assay><Body Weight Changes><Body Weight decreased><Cell Communication and Signaling><Cell Signaling><Chronic><Chronic stress><Cognition><Cornu Ammonis><DKFZp547I0610><DKFZp564I0682><Data><Data Collection><Degenerative Neurologic Diseases><Degenerative Neurologic Disorders><Development><Disease><Disease Progression><Disorder><ELISA><Emotional Depression><Enzyme-Linked Immunosorbent Assay><Exercise><Faculty><Family><Female><Gene Expression><Genes><Goals><Health><Hippocampus><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><In Vitro><Individual><Inflammation><Inflammation Mediators><Inflammatory><Inflammatory Response><Innate Immunity><Intracellular Communication and Signaling><Investigators><KIAA0012><Knowledge><Life><Luciferase Immunologic><Luciferases><Major Depressive Disorder><Measures><Mediating><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Mice><Mice Mammals><Micro RNA><MicroRNAs><Modeling><Molecular><Molecular Interaction><Murine><Mus><Native Immunity><Natural Immunity><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Non-Specific Immunity><Nonspecific Immunity><Pathway interactions><Pattern recognition receptor><Personal Satisfaction><Phenotype><Physiologic><Physiological><Play><Predisposition><Proteins><Psychiatric Disease><Psychiatric Disorder><Psychological Health><R15 Mechanism><R15 Program><Regulation><Reporter><Reporting><Research Design><Research Personnel><Researchers><Risk Factors><Role><Running><Signal Transduction><Signal Transduction Systems><Signaling><Social Interaction><Stress><Study Type><Susceptibility><System><TLR protein><TLR1><TLR1 gene><TLR1 protein><TLR1 receptor><Testing><Therapeutic><Toll-Like Receptor 1><Toll-Like Receptor Family Gene><Toll-like receptors><Toll/Interleukin-1 Receptor-Like><Training><Up-Regulation><Upregulation><Weight Change><Weight Loss><Weight Reduction><Wild Type Mouse><Work><anti-depressant agent><anti-depressant drugs><anti-depressants><anti-depressive agents><associated symptom><behavior response><behavior study><behavior test><behavioral response><behavioral study><behavioral test><biological adaptation to stress><biological signal transduction><body weight loss><build resilience><build resiliency><clinical depression><co-morbid symptom><co-occuring symptom><comorbid symptom><concurrent symptom><cooccuring symptom><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><depression symptom><depressive><depressive symptoms><design><designing><develop resilience><develop resiliency><developmental><enhance resilience><enhance resiliency><enzyme linked immunoassay><feeding><graduate student><hippocampal><improve resilience><improve resiliency><improved><increase resilience><increase resiliency><inflammatory mediator><knock-down><knockdown><major depression><major depression disorder><male><memory recognition><mental development><mental illness><miRNA><miRNAs><mouse model><murine model><neurodegenerative illness><next generation><novel><object recognition><pathway><physical conditioning><physical health><pre-clinical study><preclinical study><prevent><preventing><promote resilience><promote resiliency><protective effect><psychiatric illness><psychological disorder><reactioncrisis><resilience><resilience development><resilient><rsc786><sex><social><social role><spatial memory><stress reduction><stress response><stressreaction><study design><symptom association><symptom comorbidity><undergrad><undergraduate><undergraduate student><well-being><wellbeing><wildtype mouse><wt-loss>
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Heather Kingsley Caldwell

KENT STATE UNIVERSITY, KENT, OH

Exploratory lead · 20/100
Solid budget
Active award
$456,000
FY 2023

Project Title

Understanding the central embryonic vasopressin system

Grant Number:

1R15HD110963-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/2/2023

End Date:

12/31/2026

Project Abstract

PROJECT SUMMARY Compelling evidence suggests that the central embryonic vasopressin system has a role to play in sex-specific brain development and subsequent behavior. The vasopressin system is present and functional during embryonic development, with sex differences in the expression of the ligand...

Research Terms

<21+ years old><Adult><Adult Human><Affect><Aggression><Aggressive behavior><Animal Model><Animal Models and Related Studies><Antidiuretic Hormone><Anxiety><Applications Grants><Behavior><Brain><Brain Nervous System><Brain region><Cell Communication and Signaling><Cell Signaling><Chemicals><Data><Development><Diagnosis><Differences between sexes><Differs between sexes><Disease><Disorder><Embryo><Embryo Development><Embryogenesis><Embryonic><Embryonic Development><Encephalon><Female><Financial Support><Gender Bias><Glia><Glial Cells><Goals><Grant Proposals><Health><Human><Hypothalamic structure><Hypothalamus><Impairment><Individual><Intervention><Intervention Strategies><Intracellular Communication and Signaling><Kolliker's reticulum><Laboratories><Ligands><Link><Maternal Behavior><Measures><Mental Depression><Messenger RNA><Mice><Mice Mammals><Modern Man><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neurocyte><Neurodevelopmental Disorder><Neuroglia><Neuroglial Cells><Neurological Development Disorder><Neurons><Non-neuronal cell><Nonneuronal cell><Play><Position><Positioning Attribute><Receptor Protein><Receptor Signaling><Regulation><Reporting><Research><Role><Scientist><Sex Bias><Sex Differences><Sexual differences><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Social Behavior><Social Functioning><Structure><System><Testing><Time><Vasopressin Receptor><Vasopressins><Work><adulthood><beta-Hypophamine><biological signal transduction><clinical relevance><clinically relevant><depression><developmental><experiment><experimental research><experimental study><experiments><financial assistance><gliogenesis><graduate student><hypothalamic><innovate><innovation><innovative><insight><interventional strategy><mRNA><male><maternal aggression><memory recognition><model of animal><nerve cement><neural><neural circuit><neural circuitry><neural control><neural regulation><neurocircuitry><neurodevelopment><neurodevelopmental disease><neurogenesis><neuromodulation><neuromodulatory><neuronal><neuropsychiatric disease><neuropsychiatric disorder><neuroregulation><pre-clinical><preclinical><receptor><sex><sex-dependent differences><sex-related differences><sex-specific differences><social><social role><sociobehavior><sociobehavioral><synaptic circuit><synaptic circuitry><undergrad><undergraduate><undergraduate student>
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JENNIFER V HINES

OHIO UNIVERSITY ATHENS, ATHENS, OH

Exploratory lead · 20/100
Solid budget
Active award
$453,000
FY 2023

Project Title

R15 AREA: Optimizing allosteric modulation of noncoding regulatory RNA function

Grant Number:

2R15GM132841-02

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2019

End Date:

8/31/2026

Project Abstract

Project Summary Bacterial drug resistance is a significant global health threat that has turned once treatable bacterial infections (including Gram-positive infections) into deadly illnesses. To overcome this serious threat to human health, completely novel antibiotics are needed. The T-box riboswit...

Research Terms

<Achievement><Achievement Attainment><Anti-Bacterial Agents><Antibacterial Agents><Antibacterial Drug Resistance><Antibacterial Drug Resistant><Antibacterial resistant><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Assay><Bacteria><Bacterial Drug Resistance><Bacterial Infections><Binding><Bioassay><Biologic Assays><Biological Assay><Biomedical Research><Cancers><Cell Function><Cell Process><Cell physiology><Cellular Function><Cellular Physiology><Cellular Process><Chemicals><Communicable Diseases><Computing Methodologies><Conserved Sequence><Development><Docking><Drug Targeting><Elements><Eligibility><Eligibility Determination><Essential Genes><Functional RNA><Future><Gram-Positive Bacteria><Grant><Health><High Throughput Assay><Human><Hydrogen Oxide><In Vitro><Infection><Infectious Disease Pathway><Infectious Diseases><Infectious Disorder><Knowledge><Lead><Ligand Binding><Ligands><Location><Malignant Neoplasms><Malignant Tumor><Medicine><Methods><Minimum Inhibitory Concentration measurement><Minimum Inhibitory Concentrations><Miscellaneous Antibiotic><Moderate Activity><Modern Man><Molecular Dynamics Simulation><Molecular Interaction><NIGMS><National Institute of General Medical Sciences><Non-Coding><Non-Coding RNA><Non-Polyadenylated RNA><Non-translated RNA><Noncoding RNA><Nontranslated RNA><Outcome><Oxazolidinones><Pathogenicity><Pb element><Process><Protocol Screening><Public Health><RNA><RNA Binding><RNA Gene Products><RNA bound><Resistance><Ribonucleic Acid><Scientist><Scoring Method><Specificity><Subcellular Process><Testing><Therapeutic Agents><Training><Untranslated RNA><Viral><Water><Work><antagonism><antagonist><anti-bacterial><anti-bacterial drug resistance><anti-bacterial drug resistant><anti-bacterial resistance><anti-bacterial resistant><anti-cancer><antibacterial><antibacterial resistance><anticancer><bacteria infection><bacterial disease><career><computational methodology><computational methods><computational studies><computer based method><computer methods><computer studies><computing method><design><designing><developmental><drug discovery><experience><global health><heavy metal Pb><heavy metal lead><high throughput screening><improved><inhibitor><innovate><innovation><innovative><malignancy><molecular dynamics><neoplasm/cancer><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation><next generation therapeutics><noncoding><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><rational design><resistance to anti-bacterial><resistance to antibacterial><resistant><resistant to anti-bacterial><resistant to antibacterial><small molecule><success><undergrad><undergraduate><undergraduate research><undergraduate student>
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Senlin Chen

LOUISIANA STATE UNIV A&M COL BATON ROUGE, BATON ROUGE, LA

Exploratory lead · 20/100
Solid budget
Active award
$451,182
FY 2023

Project Title

Dissemination of an Adolescent Obesity Prevention Intervention to Louisiana Schools

Grant Number:

1R15HD108765-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/14/2023

End Date:

3/31/2027

Project Abstract

Abstract The goal of this R15 project is to disseminate the evidence-based SWITCH–MS intervention to Louisiana. The re-branded Louisiana-based Preventing Obesity Using Digital-assisted Movement and Eating (ProudMe) will retain the effective, school-based components of the SWITCH–MS but will also rec...

Research Terms

<13 year old><13 years of age><7th grade><Address><Administrator><Adolescent><Adolescent Youth><Adolescent obesity><BMI><BMI percentile><BMI z-score><Behavior><Black Populations><Black group><Black individual><Black people><Blacks><Body mass index><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 public health crisis><COVID19 crisis><COVID19 epidemic><COVID19 global health crisis><COVID19 global pandemic><COVID19 health crisis><COVID19 pandemic><COVID19 public health crisis><Child Health><Data><Diet><Disparities><Disparity><Dissemination and Implementation><Eating><Education><Educational aspects><Effectiveness><Environment><Evaluation><Evidence based intervention><Family><Financial cost><Food Intake><Funding><Future><General Taxonomy><Goals><Graduate Degree><Health><Hispanic Populations><Hispanic group><Hispanic individual><Hispanic people><Hispanics><Household><Informal Social Control><Infusion><Infusion procedures><Institution><Intervention><Intervention Strategies><Investigators><Iowa><Kinesiology><Knowledge><Light><Louisiana><Medical><Methods><Minority><Modeling><Monitor><Movement><Movement science><NIH><National Institutes of Health><Parents><Participant><Penetration><Persons><Phase><Photoradiation><Physical activity><Policies><Population Heterogeneity><Preventative intervention><Procedures><Quetelet index><Randomized><Randomized, Controlled Trials><Research><Research Personnel><Researchers><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-CoV2 epidemic><SARS-CoV2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Scholarship><Schools><Sedentary behavior><Sedentary life-style><Self Determination><Self Regulation><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Sight><Students><Taxonomy><Technology><Testing><Time><Training><United States National Institutes of Health><Universities><Vision><Waiting Lists><Weight><Work><age 13 years><assess effectiveness><body movement><career><child adiposity><child obesity><childhood adiposity><childhood obesity><college student><computer science><corona virus disease 2019 epidemic><corona virus disease 2019 pandemic><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><determine effectiveness><developmental psychology><diets><digital><disparities in race><disparity due to race><disparity in ethnic><diverse populations><effectiveness assessment><effectiveness evaluation><effectiveness outcome><effectiveness testing><effectiveness-related outcomes><effectiveness/implementation design><effectiveness/implementation hybrid design><ethnic based disparity><ethnic disadvantage><ethnic disparity><ethnic inequality><ethnic inequity><ethnicity disparity><evaluate effectiveness><evidence base><examine effectiveness><graduate student><heterogeneous population><implementation cost><implementation framework><implementation investment><implementation outcomes><implementation research><implementation research framework><implementation science><implementation science framework><improved><inequality due to race><inequity due to race><infusions><innovate><innovation><innovative><insight><instrument><intervention for prevention><interventional strategy><junior high><junior high school><juvenile><juvenile human><methods to study multiple-level influences><middle school><multi-level analysis><multi-level model><multilevel analysis><multilevel model><multilevel modeling><multiple data sources><new technology><novel><novel technologies><nutrition><obese adolescents><obese children><obesity among adolescents><obesity during adolescence><obesity during childhood><obesity in adolescence><obesity in adolescents><obesity in children><obesity prevention><pandemic><pandemic disease><parent><pediatric obesity><population diversity><power analysis><pre-pandemic><prevent><prevent obesity><preventing><prevention intervention><preventional intervention strategy><preventive intervention><prototype><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial disparity><racial diversity><racial inequality><racial inequity><racially diverse><racially unequal><randomisation><randomization><randomized control trial><randomly assigned><recruit><sedentary lifestyle><seventh grade><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><skills><social><socio-demographic factors><socio-economic><socio-economically><sociodemographic factors><socioeconomically><socioeconomics><sound><statistics><student training><teacher><theories><thirteen year old><thirteen years of age><training opportunity><undergrad><undergraduate><undergraduate student><university student><visual function><waist circumference><waitlist><weights><youth adiposity>
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Woodrow L. Shew

UNIVERSITY OF ARKANSAS AT FAYETTEVILLE, FAYETTEVILLE, AR

Exploratory lead · 20/100
Solid budget
Active award
$450,000
FY 2024

Project Title

High dimensional motor coding and motor dysfunction in Rett syndrome

Grant Number:

1R15NS135396-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/9/2024

End Date:

6/30/2027

Project Abstract

Project Summary/Abstract The broad, long-term goals of the proposed research are to better understand the neural underpinnings of healthy motor function and motor dysfunction in Rett syndrome and to promote undergraduate involvement in health-related research. Rett syndrome (RTT) is a neurological d...

Research Terms

<Accounting><Animal Model><Animal Models and Related Studies><Animals><BDNF><Behavior><Behavioral><Body Measures><Body measure procedure><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain region><Brain-Derived Neurotrophic Factor><Causality><Cell Communication and Signaling><Cell Signaling><Cerebroatrophic Hyperammonemia><Clinic><Code><Coding System><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Color><Complex><Computers><Corpus Striatum><Corpus striatum structure><Coxa><Data><Dimensions><Disturbance in cognition><Dysfunction><Elbow><Electrodes><Electrophysiology><Electrophysiology (science)><Encephalon><Encephalon Diseases><Epilepsy><Epileptic Seizures><Epileptics><Etiology><Event><Exercise><Face><Functional disorder><Future><Genes><Geometry><Goals><Grant><Grips><Grooming><Hand><Head><Health><Hip><Hip region structure><Impaired cognition><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Investigators><Knee><Knowledge><Left><MeCP-2 protein><MeCP2><MeCP2 protein><Measurement><Measures><Methyl CpG Binding Protein 2><Methyl CpG binding protein MeCP2><Methyl-CpG binding protein 2><Methyl-CpG-Binding Protein 2><Methyl-DNA binding protein MECP2><Mice><Mice Mammals><Modeling><Monitor><Motility><Motor><Motor Cortex><Motor Skills><Motor disability><Movement><Murine><Mus><Muscle><Muscle Tissue><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neurologic Disorders><Neurological Disorders><Neurons><Neurophysiology / Electrophysiology><Neurosciences><Outcome><Persons><Pharmacology><Physiatric Procedure><Physical Medicine Procedure><Physical Therapeutics><Physical therapy><Physiopathology><Physiotherapy><Play><Population><Postdoc><Postdoctoral Fellow><Posture><Prevalence><Publications><Research><Research Associate><Research Personnel><Researchers><Resolution><Rett Disorder><Rett Syndrome><Rodent Model><Role><Running><Scientific Publication><Seizure Disorder><Seizures><Severities><Shoulder><Signal Transduction><Signal Transduction Systems><Signaling><Speed><Striate Body><Striatum><System><Tail><Techniques><Testing><Transgenic Animals><Transgenic Mice><Translations><Treatment Efficacy><Walking><Work><arm movement><awake><biological signal transduction><body movement><causation><cognitive disability><cognitive dysfunction><cognitive loss><cognitively disabled><density><disease causation><electrophysiological><epilepsia><epileptogenic><experimental group><faces><facial><frontier><gene function><grasp><hands><high dimensionality><improved><intervention efficacy><loss of function mutation><machine vision><model of animal><motor disease><motor disorder><motor dysfunction><motor impairment><mouse model><movement impairment><movement limitation><murine model><muscular><neural><neural circuit><neural circuitry><neurocircuitry><neurological disease><neuronal><pathophysiology><pharmacologic><post-doc><post-doctoral><post-doctoral trainee><rate of change><research associates><resolutions><social role><striatal><success><synaptic circuit><synaptic circuitry><theories><therapeutic efficacy><therapy efficacy><translation><treatment strategy><undergrad><undergraduate><undergraduate student><vigilance>
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Maninder Sandey

AUBURN UNIVERSITY AT AUBURN, Auburn, AL

Exploratory lead · 20/100
Solid budget
Active award
$449,910
FY 2023

Project Title

A novel nanobody-based agonist-redirected checkpoint (ARC) molecule, aPD1-Fc-OX40L, for cancer immunotherapy

Grant Number:

1R15CA277677-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2027

Project Abstract

Immune checkpoint inhibitors (ICIs) have shown unprecedented clinical activity in a wide range of malignancies. However, their efficacy remains limited in many malignancies due to primary or acquired resistance. Targeted therapies that activate tumor necrosis factor receptor superfamily (TNFRSF) mem...

Research Terms

<Abscission><Affinity><Agonist><Animal Model><Animal Models and Related Studies><Automobile Driving><B7-H1><B7H1><Binding><Biologic Models><Biological><Biological Models><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><CD134><CD134 Ligand><CD134L><CD274><CD8><CD8B><CD8B1><CD8B1 gene><Cachectin Receptors><Cancer Patient><Cancer Treatment><Cancers><Canine Species><Canis familiaris><Cell Communication and Signaling><Cell Signaling><Characteristics><Checkpoint inhibitor><Clinical><Clinical Treatment Moab><Clinical Trials><Combined Modality Therapy><Correlative Study><Data><Disease-Free Survival><Dogs><Dogs Mammals><Drug Design><Drug Kinetics><Engineering><Ensure><Event-Free Survival><Excision><External Domain><Extirpation><Extracellular Domain><FDA approved><Failure><Fc Receptor><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Frequencies><GEM model><GEMM model><GP34><Genetically Engineered Mouse><Glycoprotein 34><Goals><Heterogeneity><Human><IV Infusion><Immune><Immune Targeting><Immune checkpoint inhibitor><Immune mediated therapy><Immunes><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Immunologically Directed Therapy><Immunooncology><Immunotherapeutic agent><Immunotherapy><Individual><Induction Therapy><Injections><Inter-tumoral heterogeneity><Intracellular Communication and Signaling><Intravenous infusion procedures><Investigational New Drug Application><Knowledge><LYT3><Libraries><Lymphatic cell><Lymphocyte><Lymphocytic><Malignant Melanoma><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Mediating><Melanoma Cell><Metastasis to the Lung><Metastatic Neoplasm to the Lung><Metastatic Tumor to the Lung><Model System><Modern Man><Molecular><Molecular Interaction><Monoclonal Antibodies><Multimodal Therapy><Multimodal Treatment><NEOADJ><Neoadjuvant><Neoadjuvant Therapy><Neoadjuvant Treatment><OX40><OX40 Ligand><OX40L><Oral><Outcome><PBMC><PD 1><PD-1><PD-1 blockade><PD-1/PD-L1><PD-1/PDL1><PD-L1><PD1><PD1 blockade><PD1-PD-L1><PD1/PD-L1><PD1/PDL1><PDL-1><PDL1><Pathologic><Pathway interactions><Patients><Peripheral Blood Mononuclear Cell><Persons><Pharmacokinetics><Phase 1/2 Clinical Trial><Phase 2/3 Clinical Trial><Phase I/II Clinical Trial><Phase II/III Clinical Trial><Pre-Clinical Model><Preclinical Models><Programmed Cell Death 1 Ligand 1><Programmed Death Ligand 1><Receptor Protein><Regulatory T-Lymphocyte><Removal><Research><Resistance><Rodent><Rodentia><Rodents Mammals><Safety><Signal Transduction><Signal Transduction Systems><Signaling><Stable Disease><Students><Surgical Removal><T-Cells><T-Lymphocyte><TNF Receptor Family Protein><TNF Receptor Superfamily><TNF Receptors><TNFR><TNFSF4><TNFSF4 gene><TXGP1><Teff cell><Testing><Therapeutic><Toxic effect><Toxicities><Treg><Tumor Necrosis Factor Receptor><Tumor Necrosis Factor Receptor Family><Tumor Necrosis Factor Receptor Superfamily><aPD-1><aPD1><anti programmed cell death 1><anti-PD-1><anti-PD-1 blockade><anti-PD1><anti-PD1 blockade><anti-cancer immunotherapy><anti-cancer therapy><anti-programmed cell death protein 1><anti-tumor effect><anti-tumor immune response><antiPD-1><antiPD1><antibody receptor><anticancer immunotherapy><anticancer therapy><antitumor effect><antitumor immune response><biologic><biological signal transduction><cancer immunotherapy><cancer microenvironment><cancer therapy><cancer-directed therapy><canine><check point blockade><checkpoint blockade><clinical efficacy><combination therapy><combined modality treatment><combined treatment><crosslink><design><designing><domestic dog><driving><effector T cell><flexibility><flexible><flow cytophotometry><genetically engineered mouse model><genetically engineered murine model><global gene expression><global transcription profile><human model><immune check point><immune check point blockade><immune check point inhibitor><immune checkpoint><immune checkpoint blockade><immune drugs><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based cancer therapies><immune-based therapeutics><immune-based therapies><immune-based treatments><immune-oncology><immunecheckpoint><immuno oncology><immuno therapy><immunologic therapeutics><immunology oncology><immunosuppressive check point><immunosuppressive checkpoint><immunotherapeutics><immunotherapy agent><immunotherapy for cancer><immunotherapy of cancer><induction therapies><information gathering><innovate><innovation><innovative><insight><intertumoral heterogeneity><intervention design><intravenous infusion><lung metastasis><lymph cell><mAbs><malignancy><melanoma><member><metastasize to the lung><model of animal><model of human><monoclonal Abs><mucosal melanoma><multi-modal therapy><multi-modal treatment><nanobodies><nanobody><neoplasm/cancer><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><oncoimmunology><pathway><patient response><patient specific response><peripheral blood><programmed cell death 1><programmed cell death ligand 1><programmed cell death protein 1><programmed cell death protein ligand 1><programmed death 1><protein death-ligand 1><pulmonary metastasis><receptor><regulatory T-cells><resection><resistant><response><responsive patient><safety assessment><sdAb><single domain antibodies><sle2><student engagement><student motivation><student participation><student training><systemic lupus erythematosus susceptibility 2><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapy design><thymus derived lymphocyte><transcriptome><treatment design><treatment strategy><tumor><tumor microenvironment><tumor necrosis factor ligand superfamily member 4><αPD-1><αPD1>
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Vipuil Kishore

FLORIDA INSTITUTE OF TECHNOLOGY, MELBOURNE, FL

Exploratory lead · 20/100
Solid budget
Active award
$449,837
FY 2023

Project Title

3D Printed Biomimetic Bioglass-Gradient Matrices for ACL Reconstruction

Grant Number:

2R15AR071102-02

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2017

End Date:

4/30/2027

Project Abstract

Project Summary Anterior cruciate ligament (ACL) is a band of connective tissue that connects the femur and the tibia and plays a crucial role in stabilizing the knee joint. ACL ruptures are very serious musculoskeletal injuries with poor self-healing capability and often mandate surgical intervent...

Research Terms

<3-D print><3-D printer><3D Print><3D printer><3D printing><ACL healing><ACL reconstruction><ACL repair><ACL rupture><ACL tear><Acceleration><Affect><Anterior Cruciate Ligament><Architecture><Autograft><Autologous Transplantation><Autotransplant><Biochemical><Bioglass><Biological Mimetics><Biomimetics><Biophysics><Body Tissues><Bone Formation><Bone Grafting><Bone Transplantation><Bone-Derived Transforming Growth Factor><Cell Body><Cell Differentiation><Cell Differentiation process><Cell Lineage><Cell Locomotion><Cell Migration><Cell Movement><Cells><Cellular Migration><Cellular Motility><Clinical><Collagen><Collagen Fiber><Complex><Connective Tissue><Cues><Degenerative Arthritis><Degenerative polyarthritis><Domestic Rabbit><Dose><Engineering / Architecture><Failure><Female><Femur><Fiber><Fibrocartilages><Functional Regeneration><Goals><Health Care Costs><Health Costs><Healthcare Costs><Heterogeneity><IR/UV/Raman Spectroscopy><Implant><In Vitro><Inflammatory Response><Ink><Joints><Knee joint><Length><Ligaments><Magnetism><Mechanics><Methodology><Milk Growth Factor><Minerals><Modeling><Motility><Natural regeneration><Operative Procedures><Operative Surgical Procedures><Oryctolagus cuniculus><Osteoarthritis><Osteoarthrosis><Osteogenesis><Outcome><Outcome Measure><Patients><Performance><Phase><Phenotype><Platelet Transforming Growth Factor><Play><Predisposition><Printing><Process><Production><Rabbits><Rabbits Mammals><Raman Spectroscopy><Raman Spectrum Analysis><Raman imaging><Raman spectrometry><Reconstructive Surgical Procedures><Regeneration><Reporting><Role><Rotator Cuff><Scheme><Side><Site><Surgical><Surgical Interventions><Surgical Procedure><Susceptibility><TGF B><TGF-beta><TGF-β><TGFbeta><TGFβ><Techniques><Technology><Teen><Teenagers><Tendon structure><Tendons><Tissue Engineering><Tissue Grafts><Tissues><Training><Transforming Growth Factor beta><Transforming Growth Factor-Beta Family Gene><Up-Regulation><Upregulation><Viscosity><anterior cruciate ligament healing><anterior cruciate ligament reconstruction><anterior cruciate ligament repair><anterior cruciate ligament rupture><anterior cruciate ligament tear><articular cartilage><autologous graft><autotransplantation><bioengineered tissue><biophysical foundation><biophysical principles><biophysical sciences><bone><bone strength><bone tissue formation><bone transplant><cell motility><clinical translation><clinically translatable><cost><degenerative joint disease><design><designing><determine efficacy><dosage><early onset><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><engineered tissue><evaluate efficacy><examine efficacy><fibrocartilaginous><graft failure><healing><hypertrophic arthritis><implantation><improved><indexing><injury of musculoskeletal system (disorder)><injury of musculoskeleted system><innovate><innovation><innovative><interfacial><joint function><magnetic><male><measurable outcome><mechanic><mechanical><mineralization><musculoskeletal injury><musculoskeletal trauma><novel><osteoarthritic><outcome measurement><reconstruction surgery><reconstructive surgery><regenerate><scaffold><scaffolding><sex><social role><success><surgery><teen years><teenage><three dimensional printing><tibia><tissue grafting><undergrad><undergraduate><undergraduate student>
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Daniela Stan Raicu

DE PAUL UNIVERSITY, CHICAGO, IL

Exploratory lead · 20/100
Solid budget
Active award
$449,595
FY 2025

Project Title

VS-EDGE: Visual-Semantic Explanations for Diagnostic Guidance

Grant Number:

1R15CA297521-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/16/2025

End Date:

5/31/2028

Project Abstract

PROJECT SUMMARY Technological innovations such as computer-aided diagnosis (CAD) systems can be of value in analyzing the sixty billion radiological images that are generated annually in America’s healthcare sector. However, there is a large gap between the number of CAD systems reported in the scie...

Research Terms

<Acceleration><Accuracy of Diagnosis><Award><Biomedical Research><Black Box><Breast Cancer><CAT scan><CT X Ray><CT Xray><CT imaging><CT scan><CXR><Cancers><Career Choice><Career Path><Characteristics><Clinical><Cognition><Cognitive><Complement><Complement Proteins><Computed Tomography><Computer Systems><Computer aided diagnosis><Computer-Assisted Diagnosis><Computers><Data><Decision Making><Detection><Development><Diagnosis><Diagnostic><Diagnostic Errors><E-learning><Effectiveness><Environment><Faculty><Future><General Radiology><Goals><Grant><Health Care Sector><Human><Image><Intuition><Knowledge><Learning><Link><Literature><Lung nodule><Machine Learning><Malignant Breast Neoplasm><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Medical><Mission><Modeling><Modern Man><Nodule><Pattern><Peer Review><Physicians><Physics><Position><Positioning Attribute><Process><Public Health><Publications><Pulmonary Cancer><Pulmonary imaging><Pulmonary malignant Neoplasm><Radiography><Radiology><Radiology Specialty><Reporting><Research><Roentgenography><Science><Scientific Advances and Accomplishments><Scientific Publication><Second Opinions><Semantics><Series><Shapes><Sight><Spiculate><Spiculation><System><Technology><Texture><Thoracic Radiography><Tomodensitometry><Trust><Universities><Vision><Visual><Visual Cortex><Visual Perception><Visualization><X-Ray CAT Scan><X-Ray Computed Tomography><X-Ray Computerized Tomography><Xray CAT scan><Xray Computed Tomography><Xray computerized tomography><biomed informatics><biomedical informatics><cancer diagnosis><cancer prevention><career aspiration><career interest><career pathway><career track><catscan><chest X ray><chest Xray><chest radiography><clinical practice><clinical significance><clinically significant><college><collegiate><complementation><computed axial tomography><computer aided detection><computer assisted detection><computer science><computer tomography><computer-aided diagnostic><computer-assisted diagnostics><computer-assisted instruction><computer-based education><computer-based instruction><computer-based learning><computer-based training><computerized axial tomography><computerized tomography><computing system><deep learning based model><deep learning based neural network><deep learning model><deep learning neural network><deep neural net><deep neural network><design><designing><developmental><diagnosis errors><diagnostic ability><diagnostic accuracy><diagnostic capability><diagnostic power><diagnostic technologies><diagnostic tool><diagnostic utility><diagnostic value><digital education><digital learning><digital media><eLearning><electronic learning><expectation><graduate student><imaging><improved><innovate><innovation><innovative><internet-assisted education><internet-based training><intuitive><lung cancer><lung cancer early detection><lung cancer screening><lung imaging><lung radiography><lung scanning><machine based learning><malignancy><malignant breast tumor><multimedia learning><neoplasm/cancer><neural net architecture><neural network architecture><non-contrast CT><noncontrast CT><noncontrast computed tomography><novel><object recognition><on-line education><on-line learning><online education><online learning><pulmonary nodule><radiographic chest image><radiographic lung image><radiological imaging><radiologist><scientific accomplishments><scientific advances><semantic processing><skills><survivorship><tech development><technological innovation><technology development><technology-enhanced learning><thoracic radiogram><thorax radiography><undergrad><undergraduate><undergraduate student><virtual learning><visual cortical><visual function><visual process><visual processing><web-based instruction><web-based training>
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JONATHON T HILL

BRIGHAM YOUNG UNIVERSITY, PROVO, UT

Exploratory lead · 20/100
Solid budget
Active award
$449,350
FY 2024

Project Title

Developing a CRISPR-based forward-genetic screening method in embryonic zebrafish

Grant Number:

2R15HD098969-02A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2019

End Date:

8/31/2027

Project Abstract

Abstract One of the best methods for identifying novel genes and mutations affecting embryonic development is forward genetic screening. However, these screens require a large number of animals to be screened to identify a single novel mutant due to the inefficiency of chemical mutagenesis. Our cur...

Research Terms

<1-Ethyl-1-nitrosourea><Acute><Adoption><Affect><Alleles><Allelomorphs><Amaze><Animals><Area><Atrial><Automobile Driving><Birth Defects><Body Tissues><Brachydanio rerio><CRISPR><CRISPR approach><CRISPR based approach><CRISPR editing screen><CRISPR library><CRISPR method><CRISPR methodology><CRISPR screen><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based library><CRISPR-based method><CRISPR-based screen><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 library><CRISPR/Cas9 screen><CRISPR/Cas9 technology><Calcium><Calcium Ion Signaling><Calcium Signaling><Candidate Disease Gene><Candidate Gene><Cardiac><Cardiac Atrium><Cardiac development><Cas nuclease technology><Causality><Cell Body><Cell Communication and Signaling><Cell Count><Cell Number><Cell Signaling><Cells><Chemicals><Chromosome Mapping><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats library><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Congenital Abnormality><Congenital Anatomical Abnormality><Congenital Cardiac Defects><Congenital Defects><Congenital Deformity><Congenital Heart Defects><Congenital Malformation><Danio rerio><Dedications><Defect><Development><Developmental Biology><Developmental Process><Diagnosis><ENU><Education><Educational aspects><Embryo><Embryo Development><Embryogenesis><Embryonic><Embryonic Development><Embryonic Heart><Ethylnitrosourea><Etiology><Exhibits><Exocytosis><Experimental Designs><Fluorescence><Future><Gene Alteration><Gene Localization><Gene Mapping><Gene Mapping Genetics><Gene Mutation><Gene Targeting><Gene Transcription><Generations><Genes><Genetic Alteration><Genetic Change><Genetic Screening><Genetic Transcription><Genetic defect><Genetic screening method><Genetics-Mutagenesis><Genome><Grant><Heart><Heart Atrium><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><Human><Injections><Institution><Intracellular Communication and Signaling><Ligands><Linkage Mapping><Measures><Mentorship><Methods><Modern Man><Modernization><Morphogenesis><Morphology><Mutagenesis><Mutagenesis Molecular Biology><Mutate><Mutation><N-Ethyl-N-nitrosourea><N-ethyl-N-nitroso-urea><Nitrosoethylurea><Pathway interactions><Phenotype><Proteins><RNA Expression><Rapid screening><Research><Research Resources><Resources><Role><Science><Screening Result><Signal Transduction><Signal Transduction Systems><Signaling><Source><Speed><Students><System><Tail><Testing><Time><Tissues><Total Human and Non-Human Gene Mapping><Transcription><Underrepresented Groups><Underrepresented Populations><United States><Ventricular><Width><Work><Zebra Danio><Zebra Fish><Zebrafish><accurate diagnosis><atrium><biological signal transduction><candidate identification><cardiogenesis><causal allele><causal gene><causal mutation><causal variant><causation><causative mutation><causative variant><clustered regularly interspaced short palindromic repeats screen><developmental><disability><discover genes><disease causation><driving><embryo heart><expectation><experience><experiment><experimental research><experimental study><experiments><gene discovery><genetic mapping><genome mutation><heart development><heart formation><human disease><improved><interest><malformation><model organism><morphogenetic process><mutant><novel><pathway><programs><screening><screenings><skills><social role><transgene expression><under representation of groups><under represented groups><under represented people><under represented populations><undergrad><undergraduate><undergraduate student><underrepresentation of groups><underrepresented people><vesicle transport><vesicular transport>
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Hua Lin

OKLAHOMA STATE UNIVERSITY STILLWATER, STILLWATER, OK

Exploratory lead · 20/100
Solid budget
Active award
$448,800
FY 2023

Project Title

Shared Language Erosion Among Chinese Immigrant Families

Grant Number:

1R15HD112867-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/5/2023

End Date:

8/31/2026

Project Abstract

Project Summary/Abstract Accusations regarding the origins of COVID-19 and ongoing anti-China rhetoric have provoked increases in mental health problems (MHPs) such as anxiety, depression, and suicidal thoughts and behaviors among Chinese American immigrant (CAI) families. Yet, little is known about...

Research Terms

<0-11 years old><Academic Research Enhancement Awards><Address><Affect><Age><Anxiety><Area><Asian><Asian Americans><Asian group><Asian individual><Asian people><Asian population><Asians><Attention><Automobile Driving><Buffers><COVID-19><COVID19><CV-19><CV19><Charge><Child><Child Rearing><Child Youth><Children (0-21)><China><Chinese><Chinese American><Chinese group><Chinese individual><Chinese people><Chinese population><Cities><Cognitive Discrimination><Communication><Communities><Competence><Conflict><Conflict (Psychology)><Data><Development><Discrimination><Emotional><English Language><Environmental Factor><Environmental Risk Factor><Ethnic Group><Ethnic Origin><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity><Ethnicity People><Ethnicity Population><Exhibits><Family><Family member><Feeling><Feeling suicidal><Female><Foundations><Frustration><Gender><Generalized Growth><Generations><Groups at risk><Growth><Health Care Providers><Health Personnel><Healthcare Providers><Healthcare worker><Home><Home for seniors><Homes for the Aged><Immigrant><Immigrant family><Individual><Intervention><Intervention Strategies><Knowledge><Language><Language Development><Linguistic><Linguistics><Literature><Mainland China><Mediating><Mental Depression><Mental Health><Mental Health Services><Mental Hygiene><Mental Hygiene Services><Mental disorders><Mental health disorders><Mentors><Monitor><Nature><Old Age Homes><Parenting><Parenting behavior><Parents><Pathway interactions><People at risk><Persons at risk><Population><Population Growth><Populations at Risk><Prevalence><Preventative strategy><Prevention strategy><Preventive strategy><Process><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Public Health><R-Series Research Projects><R01 Mechanism><R01 Program><R15 Mechanism><R15 Program><Racial Group><Research><Research Grants><Research Project Grants><Research Projects><Role><Sampling><Schools><Science><Stress><Structure><Subgroup><Suicidal thoughts><Suicide attempt><Testing><Time><Tissue Growth><Woman><Work><Youth><Youth 10-21><acquiring language skills><ages><behavior outcome><behavioral health><behavioral outcome><bilingual><bilingualism><childrearing><coping><corona virus disease 2019><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><depression><developmental><driving><environmental risk><ethnic identity><ethnic subgroup><ethnicity group><evidence base><experienced discrimination><feelings><health care personnel><health care worker><health provider><health workforce><healthcare personnel><home for elderly><homes><innovate><innovation><innovative><interventional strategy><kids><language acquisition><language learning><medical personnel><mental health care><mental healthcare><mental illness><non fatal attempt><nonfatal attempt><novel><ontogeny><parent><pathway><perceived discrimination><perception of discrimination><preference><prevent><preventing><protective factors><psychiatric illness><psychological disorder><racial identity><racial population><racial subgroup><recruit><self-reported discrimination><skills><social role><stressor><suicidal attempt><suicidal behavior><suicidal ideation><suicidal thinking><suicide behavior><suicide ideation><suicide rate><thoughts about suicide><treatment provider><undergrad><undergraduate><undergraduate student><youngster>
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Valery Zurabovich Grdzelishvili

UNIVERSITY OF NORTH CAROLINA CHARLOTTE, CHARLOTTE, NC

Exploratory lead · 20/100
Solid budget
Active award
$448,536
FY 2024

Project Title

Understanding and improving novel oncolytic viruses for pancreatic cancer

Grant Number:

1R15CA280729-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a poor prognosis and accounts for upwards of 95% of all pancreatic cancers. With the rise in incidence, PDAC will soon be the second leading cause of cancer-related deaths in the United States. Despite rec...

Research Terms

<Abscission><Academic Research Enhancement Awards><Adenoviridae><Adenoviruses><Antioncogene Protein p53><Armenia><Award><Biological Markers><Biology><Cancer Cause><Cancer Etiology><Cancers><Cell Body><Cell Communication and Signaling><Cell Line><Cell Signaling><CellLine><Cells><Cellular Tumor Antigen P53><Cessation of life><Characteristics><Chemoresistance><China><Chronic><Clinical><Combined Modality Therapy><Complex><Data><Death><Delta Agent><Delta Virus><Development><Disease><Disorder><Drugs><Early Diagnosis><Early-Stage Clinical Trials><Enteral><Enteric><Environment><European Community><European Union><Evolution><Excision><Extirpation><FDA approved><Friends><Glioblastoma><Goals><Grade IV Astrocytic Neoplasm><Grade IV Astrocytic Tumor><Grade IV Astrocytoma><Grant><HNSCC><HSV-1><HSV1><Head and Neck Squamous Cell Carcinoma><Hepatitis D Virus><Hepatitis Delta Virus><Hepatitis δ Virus><Herpes Simplex Type 1><Herpes Simplex Virus 1><Herpes Simplex Virus Type 1><Herpesvirus 1><Host Factor><Host Factor Protein><Human><IFN><Immune mediated therapy><Immunocompetent><Immunologically Directed Therapy><Immunotherapy><In Vitro><Incidence><Inflammation><Integration Host Factors><Interferons><Intracellular Communication and Signaling><JAK-2><JAK1><JAK1 gene><JAK1 protein><JAK1A><JAK2><JAK2 gene><JAK2 protein><Jak1 kinase><Janus kinase 1><Janus kinase 2><Japan><Laboratories><Latvia><Mainland China><Malignant Cell><Malignant Melanoma><Malignant Neoplasms><Malignant Pancreatic Neoplasm><Malignant Tumor><Malignant neoplasm of pancreas><Mediating><Medication><Melanoma><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Modern Man><Molecular><Multimodal Therapy><Multimodal Treatment><Neoplasm Metastasis><Non-Malignant><Normal Tissue><Normal tissue morphology><Oncolytic><Oncolytic viruses><Oncoprotein p53><Operative Procedures><Operative Surgical Procedures><Orphan><P53><PD-1 antibody><PD1 antibody><PDA model><PDAC Model><PDAC cancer cell><PDAC cell><Pancreas Cancer><Pancreas Ductal Adenocarcinoma><Pancreatic Cancer><Pancreatic Ductal Adenocarcinoma><Patients><Pharmaceutical Preparations><Phase 1 Clinical Trials><Phase I Clinical Trials><Phenotype><Phosphoprotein P53><Phosphoprotein pp53><Prognosis><Protein TP53><Publishing><R15 Mechanism><R15 Program><Relapse><Removal><Reporting><Research><Research Resources><Resectable><Residual><Residual state><Resistance><Resources><SCCHN><Safety><Secondary Neoplasm><Secondary Tumor><Signal Transduction><Signal Transduction Systems><Signaling><Strains Cell Lines><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><System><TP53><TP53 gene><TRP53><Testing><Treatment-related toxicity><Tumor Immunity><Tumor Protein p53><Tumor Protein p53 Gene><Tyrosine-Protein Kinase JAK1><Tyrosine-Protein Kinase JAK2><United States><VSV><Variant><Variation><Vesicular Stomatitis Virus><Vesicular stomatitis Indiana virus><Viral><Virus><Virus Replication><Work><aPD-1><aPD1><anti programmed cell death 1><anti-PD-1><anti-PD-1 Ab><anti-PD-1 antibodies><anti-PD-1 monoclonal antibodies><anti-PD1><anti-PD1 Ab><anti-PD1 antibodies><anti-PD1 monoclonal antibodies><anti-cancer><anti-programmed cell death protein 1><anti-programmed cell death protein 1 antibodies><anti-programmed death-1 antibody><anti-tumor immune response><anti-tumor immunity><antiPD-1><antiPD1><antitumor immunity><bio-markers><biologic marker><biological signal transduction><biomarker><cancer cell><cancer immunity><cancer metastasis><cancer virotherapy><check point blockade><checkpoint blockade><chemoresistant><chemotherapeutic agent><chemotherapy><chemotherapy resistance><chemotherapy resistant><clinical relevance><clinically relevant><combination therapy><combinatorial><combined modality treatment><combined treatment><cultured cell line><determine efficacy><developmental><drug/agent><early detection><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><experiment><experimental research><experimental study><experiments><glioblastoma multiforme><head and neck squamous carcinoma><head and neck squamous cell cancer><herpes simplex i><herpes simplex-1><immune check point blockade><immune checkpoint blockade><immune competent><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><improved><in vivo><inhibitor><malignancy><mouse model><multi-modal therapy><multi-modal treatment><murine model><neoplasm/cancer><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><nonmalignant><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><novel virus><oncolysis><oncolytic VSV><oncolytic Vesicular Stomatitis Virus><oncolytic viral therapeutic><oncolytic viral therapy><oncolytic virotherapeutic><oncolytic virotherapy><oncolytic virus therapy><p53 Antigen><p53 Genes><p53 Tumor Suppressor><pancreatic ductal adenocarcinoma cell><pancreatic ductal adenocarcinoma model><pancreatic malignancy><permissiveness><phase I protocol><pre-clinical><preclinical><programs><protein p53><resection><resistance mechanism><resistant><resistant mechanism><response><spongioblastoma multiforme><success><surgery><therapeutic toxicity><therapy associated toxicity><therapy related toxicity><therapy toxicity><treatment toxicity><treatment-associated toxicity><tumor><tumor cell metastasis><undergrad><undergraduate><undergraduate education><undergraduate student><viral multiplication><viral replication><virus multiplication><αPD-1><αPD1>
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Jingchun Chen

UNIVERSITY OF NEVADA LAS VEGAS, LAS VEGAS, NV

Exploratory lead · 20/100
Solid budget
Active award
$447,509
FY 2024

Project Title

Convolutional Neural Network for Disease Prediction, Biomarker Discovery, and Validation in Alzheimer's Disease

Grant Number:

1R15AG083618-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2024

End Date:

5/31/2027

Project Abstract

ABSTRACT Alzheimer's disease (AD) is the most common dementia affecting more than six million people in the United States. The complex genetic risk and the lack of disease-specific biomarkers for AD are among the most challenges that investigators and clinicians face in early prediction, diagnosis, ...

Research Terms

<AD dementia><AD model><AD prevention><AI algorithm><AI system><Acceleration><Affect><African ancestry><African descent><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease prevention><Alzheimer prevention><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's biomarker><Alzheimer's disease biological marker><Alzheimer's disease model><Alzheimer's disease risk><Alzheimers Dementia><Alzheimer’s biological marker><Alzheimer’s disease biomarker><Amentia><Area Under Curve><Artificial Intelligence><Astrocytes><Astrocytus><Astroglia><Big Data><BigData><Biological Markers><Biometrics><Biometry><Biostatistics><Breast Cancer><Classification><Clinic><Clinical><Collaborations><Complex><Computer Reasoning><Connectionist Models><ConvNet><Coupled><Data><Data Analyses><Data Analysis><Data Set><Dementia><Diagnosis><Dimensions><Disease><Disorder><Early Diagnosis><Early identification><Effectiveness><European><Face><Faculty><Future><GWA study><GWAS><Gene variant><Genes><Genetic><Genetic Heterogeneity><Genetic Models><Genetic Risk><Genotype><Goals><Grant><Health Inequity><Hortega cell><Image><Individual><Inequalities in Health><Inequities in Health><Intervention><Intervention Strategies><Investigators><Logistic Regressions><Machine Intelligence><Machine Learning><Malignant Breast Neoplasm><Maps><Medical><Methods><Microglia><Modeling><Multiomic Data><Neural Network Models><Neural Network Simulation><Pathway interactions><Pattern><Perceptrons><Performance><Persons><Population><Preservation Technique><Prevention><Primary Senile Degenerative Dementia><RNA Seq><RNA sequencing><RNAseq><Regression Analyses><Regression Analysis><Regression Diagnostics><Research><Research Activity><Research Personnel><Research Resources><Researchers><Resources><Risk Assessment><Schizophrenia><Schizophrenic Disorders><Single Base Polymorphism><Single Nucleotide Polymorphism><Statistical Regression><Students><Symptoms><Systematics><Techniques><Testing><Translating><United States><Validation><Variant><Variation><allele variant><allelic variant><alzheimer model><alzheimer risk><artificial intelligence algorithm><astrocytic glia><bio-markers><biologic marker><biomarker><biomarker discovery><biomarker identification><biomarker validation><career><career development><cell type><clinical practice><co-morbid><co-morbidity><comorbidity><computer based prediction><convolutional network><convolutional neural nets><convolutional neural network><data interpretation><data-driven model><dementia praecox><dementia risk><design><designing><differential expression><differentially expressed><disease classification><disease heterogeneity><disease model><disease risk><disorder classification><disorder model><disorder risk><drug development><drug discovery><early biomarkers><early detection><early detection biomarkers><early detection markers><effective therapy><effective treatment><faces><facial><field based data><field learning><field study><field test><genetic variant><genome wide association><genome wide association scan><genome wide association studies><genome wide association study><genomewide association scan><genomewide association studies><genomewide association study><genomic variant><gitter cell><health inequalities><high risk><high risk group><high risk individual><high risk people><high risk population><identification of biomarkers><identification of new biomarkers><imaging><improved><innovate><innovation><innovative><insight><interest><interventional strategy><machine based learning><machine learned algorithm><machine learning algorithm><machine learning based algorithm><malignant breast tumor><marker identification><marker validation><member><mesoglia><microglial cell><microgliocyte><multiple omic data><neural network algorithm><new approaches><nosology><novel approaches><novel strategies><novel strategy><pathway><perivascular glial cell><polygenic risk score><predictive modeling><primary degenerative dementia><random forest><risk factor for dementia><risk for dementia><scRNA-seq><schizophrenic><senile dementia of the Alzheimer type><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single nucleotide variant><single-cell RNA sequencing><specific biomarkers><statistics><success><support vector machine><therapeutic target><trait><transcriptional differences><transcriptome sequencing><transcriptomic sequencing><validations><whole genome association analysis><whole genome association studies><whole genome association study>
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Seth Armah

UNIVERSITY OF NORTH CAROLINA GREENSBORO, GREENSBORO, NC

Exploratory lead · 20/100
Solid budget
Active award
$447,165
FY 2022

Project Title

Effect of almond consumption on iron status in inflammatory states

Grant Number:

1R15DK128756-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/15/2022

End Date:

7/31/2026

Project Abstract

Project Summary/Abstract Anemia of inflammation (AI) is the second most prevalent form of anemia. It is caused by chronic inflammation associated with aging and chronic diseases such as cancer and rheumatoid arthritis. While people with AI have sufficient body iron, increased sequestration due to el...

Research Terms

<ANOVA><Academic Research Enhancement Awards><Adverse effects><Affect><Aging><Analysis of Variance><Anemia><Anemia due to Chronic Disorder><Antioxidants><Atrophic Arthritis><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Blood Plasma><Blood Transfusion><Blood erythrocyte><C57BL/6 Mouse><Calories><Cancers><Cellular injury><Chronic><Chronic Disease><Chronic Illness><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Consumption><CuZnSOD><Data><Diet><Disturbance in cognition><Drug Targeting><ECSF><Elderly><Epoetin><Erythrocyte Count><Erythrocyte Measurement><Erythrocyte Number><Erythrocytes><Erythrocytic><Erythropoietin><Fat-Restricted Diet><Fats><Fatty acid glycerol esters><Fe deficiency><Fe element><Fe supplementation><GI microbiome><GI microbiota><Gastrointestinal microbiota><Goals><HPGF><Health><Hematology><Hemoglobin><Hepatocyte-Stimulating Factor><Hepc peptide><High Fat Diet><Hospital Admission><Hospitalization><Hybridoma Growth Factor><IFN-beta 2><IFNB2><IL-6><IL6 Protein><Immunity><Impaired cognition><Impairment><Individual><Inflammation><Inflammatory><Intake><Intention><Interleukin-6><Intervention><Intervention Strategies><Intravenous><Iron><Lead><Low-Fat Diet><MGI-2><Macrophage Activation><Malignant Neoplasms><Malignant Tumor><Marrow erythrocyte><Measurement><Measures><Mice><Mice Mammals><Modeling><Murine><Mus><Myeloid Differentiation-Inducing Protein><Mφ><Nutrition Research><Nutritional Study><Obesity><Pb element><Persons><Plasma><Plasma Serum><Plasmacytoma Growth Factor><Population><Populations at Risk><Production><Productivity><Proteins><QOL><Quality of life><R15 Mechanism><R15 Program><Randomized><Recurrence><Recurrent><Red Blood Cell Count><Red Blood Cells><Red Cell><Research><Reticuloendothelial System, Serum, Plasma><Rheumatoid Arthritis><Risk><Source><Suggestion><System><Testing><Therapeutic><Time><Transfusion><Variance Analyses><Vitamin E><Work><adiposity><advanced age><alpha Tocopherol><anemia of chronic disease><anemia of inflammation><anti-oxidant><base><blood corpuscles><cell damage><cell injury><cellular damage><chronic disorder><cognitive dysfunction><cognitive loss><copper zinc superoxide dismutase><corpulence><damage to cells><diet control><dietary approach><dietary control><diets><digestive tract microbiome><elders><enteric microbial community><enteric microbiome><enteric microbiota><erythrocyte colony stimulating factor><falls><gastrointestinal microbial flora><gastrointestinal microbiome><geriatric><gut commensal><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><heavy metal Pb><heavy metal lead><hematopoietin><hepcidin><improved><inflammation marker><inflammatory marker><injury to cells><interferon beta 2><interventional strategy><intestinal biome><intestinal flora><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><iron deficiency><iron supplementation><late life><later life><macrophage><malignancy><microbial><microbiome community composition><microbiome composition><microbiome species composition><mortality><mouse model><murine model><neoplasm/cancer><older adult><older person><oxidative damage><oxidative injury><premature><prematurity><prevent><preventing><randomisation><randomization><randomly assigned><rheumatic arthritis><senior citizen><training opportunity><undergrad><undergraduate><undergraduate student><α-Tocopherol>
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Arthur R Frampton

UNIVERSITY OF NORTH CAROLINA WILMINGTON, WILMINGTON, NC

Exploratory lead · 20/100
Solid budget
Active award
$447,000
FY 2023

Project Title

Enhanced delivery of site-specific DNA damaging toxins to prostate cancercells

Grant Number:

1R15CA274393-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/8/2023

End Date:

2/28/2027

Project Abstract

ABSTRACT The overall goal of our research is to develop a dependable strategy for selectively targeting different cancer cells and producing specific types of DNA-damage in them, leading to their targeted destruction. These molecules will help us understand DNA-damage mediated biological processes i...

Research Terms

<1H-Purin-6-amine><Address><Adenine><Affinity><African American><Afro American><Afroamerican><Androgen Receptor><Androgenic Agents><Androgenic Compounds><Androgens><Animal Model><Animal Models and Related Studies><Apoptosis><Apoptosis Pathway><Artificial Membranes><Assay><Binding><Bioassay><Biologic Assays><Biological Assay><Biological Function><Biological Process><Biomedical Research><Breast Cancer><Breast Cancer Cell><Cancer Cause><Cancer Etiology><Carcinogen-DNA Adducts><Cell Body><Cell Death><Cell Membrane Permeability><Cell Nucleus><Cells><Chemotherapy Protocol><Chemotherapy Regimen><Chemotherapy-Oncologic Procedure><Combination Chemotherapy Regimen><DNA><DNA Adduct Formation><DNA Adduction><DNA Adducts><DNA Binding><DNA Binding Interaction><DNA Damage><DNA Double Strand Break><DNA Injury><DNA Methylation><DNA bound><DNA lesion><Deoxyribonucleic Acid><Detection><Development><Disease><Disorder><Epithelial Cells><Estrogen Receptors><Ethidium Bromide><Foundations><Future><Genes><Goals><HPLC><High Performance Liquid Chromatography><High Pressure Liquid Chromatography><High Speed Liquid Chromatography><Homidium Bromide><LNCaP><Lesion><Ligands><Malignant Cell><Malignant Tumor of the Prostate><Malignant neoplasm of prostate><Malignant prostatic tumor><Measures><Mediating><Methylation><Minor Groove><Molecular Biology Techniques><Molecular Interaction><Nature><Necrosis><Necrotic><Nuclear><Nuclear Receptors><Nucleus><Organic Synthesis><Outcome><PC-3><PC-3 cell line><PC3><PC3 cell line><Programmed Cell Death><Property><Prostate><Prostate CA><Prostate CA therapy><Prostate Cancer><Prostate Cancer therapy><Prostate Gland><Prostate malignancy><Prostatic Cancer><Prostatic Gland><Quimioterapia><Reaction><Research><Risk><Role><Second Cancer><Second Primary Cancers><Secondary Malignancy><Secondary Malignant Neoplasm><Site><Techniques><Testing><Therapeutic Androgen><Thymine><Toxic effect><Toxicities><Toxin><Training><Underrepresented Ethnic Minority><Underrepresented Minority><Vitamin B4><adduct><analog><breast tumor cell><calf thymus DNA><cancer cell><cancer chemotherapy><chemical standard><chemotherapy><developmental><disparities in race><disparity due to race><inequality due to race><inequity due to race><malignant breast neoplasm><malignant breast tumor><membrane permeability><model of animal><necrocytosis><overexpress><overexpression><prostate cancer cell><prostate cancer cell line><prostate cancer model><prostate cancer treatment><prostate tumor cell><prostate tumor model><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial disparity><racial inequality><racial inequity><racially unequal><receptor binding><receptor bound><response to therapy><response to treatment><secondary cancer><side effect><social role><targeted agent><therapeutic response><therapy response><tissue culture><treatment response><under-representation of minorities><under-represented minority><undergrad><undergraduate><undergraduate student><underrepresentation of minorities>
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Sridhar Varadarajan

UNIVERSITY OF NORTH CAROLINA WILMINGTON, WILMINGTON, NC

Exploratory lead · 20/100
Solid budget
Active award
$447,000
FY 2023

Project Title

Enhanced delivery of site-specific DNA damaging toxins to prostate cancercells

Grant Number:

1R15CA274393-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/8/2023

End Date:

2/28/2027

Project Abstract

ABSTRACT The overall goal of our research is to develop a dependable strategy for selectively targeting different cancer cells and producing specific types of DNA-damage in them, leading to their targeted destruction. These molecules will help us understand DNA-damage mediated biological processes i...

Research Terms

<1H-Purin-6-amine><Address><Adenine><Affinity><African American><Afro American><Afroamerican><Androgen Receptor><Androgenic Agents><Androgenic Compounds><Androgens><Animal Model><Animal Models and Related Studies><Apoptosis><Apoptosis Pathway><Artificial Membranes><Assay><Binding><Bioassay><Biologic Assays><Biological Assay><Biological Function><Biological Process><Biomedical Research><Breast Cancer><Breast Cancer Cell><Cancer Cause><Cancer Etiology><Carcinogen-DNA Adducts><Cell Body><Cell Death><Cell Membrane Permeability><Cell Nucleus><Cells><Chemotherapy Protocol><Chemotherapy Regimen><Chemotherapy-Oncologic Procedure><Combination Chemotherapy Regimen><DNA><DNA Adduct Formation><DNA Adduction><DNA Adducts><DNA Binding><DNA Binding Interaction><DNA Damage><DNA Double Strand Break><DNA Injury><DNA Methylation><DNA bound><DNA lesion><Deoxyribonucleic Acid><Detection><Development><Disease><Disorder><Epithelial Cells><Estrogen Receptors><Ethidium Bromide><Foundations><Future><Genes><Goals><HPLC><High Performance Liquid Chromatography><High Pressure Liquid Chromatography><High Speed Liquid Chromatography><Homidium Bromide><LNCaP><Lesion><Ligands><Malignant Cell><Malignant Tumor of the Prostate><Malignant neoplasm of prostate><Malignant prostatic tumor><Measures><Mediating><Methylation><Minor Groove><Molecular Biology Techniques><Molecular Interaction><Nature><Necrosis><Necrotic><Nuclear><Nuclear Receptors><Nucleus><Organic Synthesis><Outcome><PC-3><PC-3 cell line><PC3><PC3 cell line><Programmed Cell Death><Property><Prostate><Prostate CA><Prostate CA therapy><Prostate Cancer><Prostate Cancer therapy><Prostate Gland><Prostate malignancy><Prostatic Cancer><Prostatic Gland><Quimioterapia><Reaction><Research><Risk><Role><Second Cancer><Second Primary Cancers><Secondary Malignancy><Secondary Malignant Neoplasm><Site><Techniques><Testing><Therapeutic Androgen><Thymine><Toxic effect><Toxicities><Toxin><Training><Underrepresented Ethnic Minority><Underrepresented Minority><Vitamin B4><adduct><analog><breast tumor cell><calf thymus DNA><cancer cell><cancer chemotherapy><chemical standard><chemotherapy><developmental><disparities in race><disparity due to race><inequality due to race><inequity due to race><malignant breast neoplasm><malignant breast tumor><membrane permeability><model of animal><necrocytosis><overexpress><overexpression><prostate cancer cell><prostate cancer cell line><prostate cancer model><prostate cancer treatment><prostate tumor cell><prostate tumor model><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial disparity><racial inequality><racial inequity><racially unequal><receptor binding><receptor bound><response to therapy><response to treatment><secondary cancer><side effect><social role><targeted agent><therapeutic response><therapy response><tissue culture><treatment response><under-representation of minorities><under-represented minority><undergrad><undergraduate><undergraduate student><underrepresentation of minorities>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Margaret Rose Bell

DE PAUL UNIVERSITY, CHICAGO, IL

Exploratory lead · 20/100
Solid budget
Active award
$446,852
FY 2022

Project Title

PCB-induced priming of microglial activity across sexes and development

Grant Number:

1R15ES033393-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2022

End Date:

7/31/2026

Project Abstract

PROJECT SUMMARY / ABSTRACT Polychlorinated biphenyls (PCBs) remain ubiquitous environmental contaminants and exposure to them is associated with increased risk of neurodevelopmental and mood disorders. These disorders tend to occur more frequently in infant male and adolescent female individuals, an...

Research Terms

<0-11 years old><12-20 years old><AD/HD><ADHD><Acute><Adolescence><Adolescent><Adolescent Youth><Affect><Affective Disorders><Age><Animal Model><Animal Models and Related Studies><Animals><Assay><Attention deficit hyperactivity disorder><Autism><Autistic Disorder><Basal Transcription Factor><Basal transcription factor genes><Bioassay><Biologic Assays><Biological Assay><Brain><Brain Nervous System><Breast Milk><Breastmilk><CMKRL2><Calcium><Cell Communication and Signaling><Cell Function><Cell Process><Cell Signaling><Cell physiology><Cellular Function><Cellular Physiology><Cellular Process><Cellular injury><Chemokine Receptor-Like 2><Child><Child Youth><Children (0-21)><Common Rat Strains><Complex Mixtures><Cytochemistry Histology><Cytokine Signal Transduction><Cytokine Signaling><Data><Development><Diet><Differences between sexes><Differs between sexes><Disease><Disorder><ELISA><Early Infantile Autism><Encephalon><Environment><Environmental Exposure><Environmental Pollution><Environmental Toxin><Enzyme Gene><Enzyme-Linked Immunosorbent Assay><Enzymes><Estrogens><Exposure to><Female><Female Adolescents><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Foundations><G Protein-Coupled Estrogen Receptor><G Protein-Coupled Receptor 30><GPER><GPER gene><GPR30><General Transcription Factor Gene><General Transcription Factors><Genes><Gestation><Glia><Glial Cells><Goals><Homolog of Drosophila TOLL><Hortega cell><Human><Human Milk><Human Mother's Milk><Immune><Immunes><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><In Vitro><Individual><Infant><Infantile Autism><Inflammatory><Institution><Intracellular Communication and Signaling><Kanner's Syndrome><Knowledge><Kolliker's reticulum><Label><Latex Bead><Male Adolescents><Mammary Gland Milk><Mental Depression><Microglia><Modern Man><Mood Disorders><Morphology><Mother's Milk><Neonatal><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neuroglia><Neuroglial Cells><Neuroimmune><Neurological Development Disorder><Neurons><Nitrogen><Non-neuronal cell><Nonneuronal cell><O element><O2 element><Outcome><Oxidative Stress><Oxygen><PCBs><Perinatal><Peripartum><Peripheral><Peroxonitrite><Persons><Phagocytosis><Pharmacology><Phenotype><Play><Policies><Polychlorinated Biphenyls><Polychlorobiphenyl Compounds><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Pregnancy><Production><Proteins><Public Health><Publishing><Rat><Rats Mammals><Rattus><Receptor Protein><Regulation><Research><Risk><Role><Sampling><Schools><Science><Sex Differences><Sexual Development><Sexual differences><Signal Transduction><Signal Transduction Systems><Signaling><Students><Subcellular Process><Synapses><Synaptic><TLR4><TLR4 gene><Target Populations><Techniques><Therapeutic><Therapeutic Estrogen><Toll Homologue><Toxic Environmental Agents><Toxic Environmental Substances><Transcription Factor Proto-Oncogene><Transcription factor genes><Underrepresented Students><Universities><Work><adolescence (12-20)><adolescent boy><adolescent girl><ages><attention deficit hyperactive disorder><autism spectrum disorder><autistic spectrum disorder><base><biological signal transduction><brain cell><building materials><career><cell damage><cell injury><cellular damage><cytochemistry><cytokine><damage to cells><depression><design><designing><developmental><diets><early life exposure><environmental contaminant><environmental contamination><environmental toxicant><enzyme linked immunoassay><flow cytophotometry><gitter cell><immunocytochemistry><in vivo><injury to cells><innovate><innovation><innovative><juvenile><juvenile human><male><maternal milk><mesoglia><microglial cell><microgliocyte><mixed cell culture><model of animal><model organism><neonate><nerve cement><neurogenesis><neuronal><perivascular glial cell><peroxynitrite><polychlorobiphenyl><prevent><preventing><receptor><response><sex><sex development><sex-dependent differences><sex-related differences><sex-specific differences><social role><synapse><therapeutic agent development><therapeutic development><therapeutic target><toll-like receptor 4><toxicant><transcription factor><undergrad><undergraduate><undergraduate student><youngster>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

CINDY L LINN

WESTERN MICHIGAN UNIVERSITY, KALAMAZOO, MI

Exploratory lead · 20/100
Solid budget
Active award
$446,433
FY 2024

Project Title

Evidence of neurogenesis in an adult mammalian retina initiated by an alpha7 nAChR agonist

Grant Number:

1R15EY035803-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2024

End Date:

2/28/2027

Project Abstract

In adult zebrafish, Müller glia are the source of new retinal neurons (57). While adult mammals also possess Müller glial cells, they do not typically possess the same regenerative abilities found in zebrafish. However, recently, this lab has provided evidence that Müller glia induce Müller glia-der...

Research Terms

<21+ years old><Address><Adult><Adult Human><Affect><After Care><After-Treatment><Aftercare><Aging><Applications Grants><BUdR><Binding><Blindness><Brachydanio rerio><BrdU><Bromodeoxyuridine><Bromouracil Deoxyriboside><Broxuridine><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Components><Cell Line><Cell Structure><CellLine><Cells><Cellular Structures><Chick><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Common Rat Strains><Computer software><Culturing, in vitro Vertebrate, Primary><DT-R><DTR gene><Danio rerio><Development><Diphtheria Toxin Receptor (Heparin-Binding EGF-Like Growth Factor) Gene><Diphtheria Toxin Receptor Gene><Diphtheria Toxin Sensitivity Gene><Disease><Disorder><Eye Drops><Eyedrops><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Ganglion Cell Layer><Genes><Glaucoma><Glia><Glial Cells><Grant Proposals><HB-EGF><HBEGF><HEGFL><Health Care Systems><Healthcare Systems><Heparin-Binding EGF-Like Growth Factor Gene><In Vitro><Kolliker's reticulum><Literature><M Phase><Macular degeneration><Macular degenerative disease><Mammalia><Mammals><Mice><Mice Mammals><Mitosis><Mitosis Stage><Mitotic><Molecular Interaction><Muller glia><Muller's cell><Murine><Mus><Müller cell><Müller glia><Natural regeneration><Neuroglia><Neuroglial Cells><Non-neuronal cell><Nonneuronal cell><Outer pigmented layer of retina><Pathway interactions><Photoreceptor Cell><Photoreceptors><Photosensitive Cell><Pigment cell layer of retina><Pigmentary Retinopathy><Pigmented layer of retina><Population><Primary Cell Cultures><Progenitor Cells><Proliferating><Publishing><QOL><Quality of life><RNA Seq><RNA sequencing><RNAseq><RT-PCR><RTPCR><Rat><Rats Mammals><Rattus><Regeneration><Reporter><Research><Retina><Retinal Degeneration><Retinal Ganglion Cells><Retinal Pigment Epithelium><Retinal pigment epithelial cells><Retinitis Pigmentosa><Reverse Transcriptase Polymerase Chain Reaction><Rodent><Rodentia><Rodents Mammals><Science><Signal Pathway><Signaling Molecule><Software><Source><Strains Cell Lines><Structure of retinal pigment epithelium><Tamoxifen><Tapetoretinal Degeneration><Technology><Testing><Training><Transgenic Mice><Traumatic injury><Vertebrate Animals><Vertebrates><Visual Receptor><Zebra Danio><Zebra Fish><Zebrafish><acetylcholine receptor agonist><adulthood><age associated><age correlated><age dependent><age linked><age related><age specific><alpha-bungarotoxin binding sites><alpha-bungarotoxin receptor><alpha7 nicotinic acetylcholine receptor><alpha7nAChR><career><cultured cell line><degenerative retina diseases><design><designing><developmental><disability><experiment><experimental research><experimental study><experiments><flow cytophotometry><fluorophore><glaucomatous><global gene expression><global transcription profile><graduate student><immunocytochemistry><knockout gene><mRNA seq><mRNA sequencing><mRNA-seq><mRNAseq><migration><nerve cement><neurogenesis><overexpress><overexpression><pathway><post treatment><regenerate><regenerative><retina degeneration><retinal degenerative><retinal degenerative diseases><retinal ganglion><retinal neuron><retinal progenitor><retinal progenitor cell><retinal regeneration><retinal stem cell><reverse transcriptase PCR><rod and cone dystrophy><rod-cone dystrophy><stem cells><transcriptome><transcriptome sequencing><transcriptomic sequencing><undergrad><undergraduate><undergraduate student><vertebrata><vision loss><visual loss><α7 nicotinic acetylcholine receptor><α7nAChR>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Yana I Sandlers

CLEVELAND STATE UNIVERSITY, CLEVELAND, OH

Exploratory lead · 20/100
Solid budget
Active award
$445,500
FY 2025

Project Title

Novel mitochondria-targeting peptides (MTPs) as therapeutic intervention in Barth syndrome

Grant Number:

1R15HL177692-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2025

End Date:

12/31/2027

Project Abstract

Mitochondria-targeting peptides (MTPs) as therapeutic intervention in Barth syndrome Barth syndrome (BTHS) is a serious X-linked recessive multisystem disorder caused by mutations in the TAZ gene (TAZ, G 4.5, OMIM 300394) that encodes for the acyltransferase tafazzin. Although BTHS is a multisystem ...

Research Terms

<3-Methylglutac aciduria type 2><3-Methylglutaconic aciduria type 2><ATP Synthesis><ATP Synthesis Pathway><ATP phosphohydrolase><ATPase><Academic Research Enhancement Awards><Acyltransferase><Address><Adenosine Triphosphatase><Affect><Amino Acids><Ampullary Crest><Anabolism><Barth syndrome><Biochemical><Bioenergetics><Biological Markers><Body Tissues><Calcium><Cardiac><Cardiac Diseases><Cardiac Disorders><Cardiolipins><Cardiomyopathies><Citric Acid Cycle><Clinical><Complex><Crista ampullaris><Critical Paths><Critical Pathways><DKFZP586I1419><DNA mutation><Data><Defect><Development><Disadvantaged minority><Disease><Disease Outcome><Disorder><Dysfunction><EC 2.3><Economically Deprived><Education><Educational aspects><Electron Transport><Endocardial Fibroelastosis><Experimental Models><FDA approved><Functional disorder><Gene Alteration><Gene Expression><Gene Mutation><Generations><Genetic Change><Genetic defect><Genetic mutation><Heart><Heart Diseases><Heart failure><Individual><Inner mitochondrial membrane><Institution><Intermediary Metabolism><Intervention><Knowledge><Knowledge acquisition><Krebs Cycle><Lead><Left ventricular non-compaction><Life><Life Expectancy><Link><Literature><Measures><Metabolic><Metabolic Processes><Metabolic dysfunction><Metabolism><Mitochondria><Mitochondrial Proteins><Modality><Modeling><Molecular><Monitor><Muscle><Muscle Tissue><Mutation><Myocardial Diseases><Myocardial Disorder><Myocardiopathies><OMIM><Online Mendelian Inheritance In Man><Outcome><Pathogenesis><Pathway interactions><Pb element><Peptides><Phosphatides><Phospholipids><Physiopathology><Play><Population><Process><Production><Property><Proteins><Publishing><R15 Mechanism><R15 Program><Regulatory Protein><Research><Respiratory Chain><Role><Services><Structural defect><Structural malformation><Structure><Students><System><TAZ gene><TCA cycle><Therapeutic Intervention><Tissues><Treatment Failure><Tricarboxylic Acid Cycle><URM student><Universities><Ventricular><Work><acylcarnitine><aminoacid><analog><bio-markers><biologic marker><biomarker><biosynthesis><cardiac failure><cardiac myocytes differentiated from induced pluripotent stem cell><causal allele><causal gene><causal mutation><causal variant><causative mutation><causative variant><clinical relevance><clinically relevant><college student><crista ampulla><cristae><developmental><disease model><disorder model><economic disparity><economically disadvantaged><effective therapy><effective treatment><electron transfer><enzyme activity><experience><gene defect><genetic regulatory protein><genome mutation><graduate student><heart disorder><heavy metal Pb><heavy metal lead><iPS><iPS cell derived cardiomyocytes><iPSC><iPSC derived cardiomyocytes><iPSCs><improved><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cell derived cardiac myocytes><induced pluripotent stem cell derived cardiomyocytes><inducible pluripotent cell><inducible pluripotent stem cell><inducible pluripotent stem cell derived cardiac myocytes><inducible pluripotent stem cells derived cardiomyocytes><intervention therapy><left ventricular noncompaction><mitochondrial><mitochondrial cardiomyopathies><mono-lysocardiolipin><monolysocardiolipin><muscular><mutant allele><myocardium disease><myocardium disorder><novel><pathophysiology><pathway><protein complex><rational design><regulatory gene product><respiratory><sex linked recessive><social role><spongy myocardium><structural abnormalities><structural anomalies><therapy failure><translational study><undergrad><undergraduate><undergraduate student><underrepresented minority student><university student><uptake><x-linked recessive>
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Margaret Bennewitz

WEST VIRGINIA UNIVERSITY, MORGANTOWN, WV

Exploratory lead · 20/100
Solid budget
Active award
$444,603
FY 2023

Project Title

Finding NEMO's Switchable MRI Signal Using Microfluidic Tumor Models

Grant Number:

1R15CA274189-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/5/2023

End Date:

6/30/2026

Project Abstract

PROJECT SUMMARY Misdiagnosis is prevalent in younger women with dense breast tissue receiving breast cancer screening, resulting in missed cancers, needless follow-up testing, anxiety, and medical costs. Compared to mammography, magnetic resonance imaging (MRI) detects more breast cancers but still ...

Research Terms

<3-D><3-Dimensional><3D><Active Follow-up><Address><Anxiety><Award><Benign><Biodistribution><Blood><Blood Reticuloendothelial System><Blood Vessels><Brain><Brain Nervous System><Breast Cancer><Breast Cancer Cell><Breast Cancer Detection><Breast Cancer Early Detection><Breast Cancer Early Screening><Breast MRI><Breast Magnetic Resonance Imaging><Breast Tissue><Breast cancer screening><Breast screening><Cancer Detection><Cancerous><Cancers><Cell Body><Cell Communication and Signaling><Cell Culture Techniques><Cell Signaling><Cell Survival><Cell Viability><Cell-Extracellular Matrix><Cells><Cellular Expansion><Cellular Growth><Characteristics><Clinic><Clinical Trials><Co-culture><Cocultivation><Coculture><Coculture Techniques><Complex Analysis><Confocal Microscopy><Contrast Agent><Contrast Drugs><Contrast Media><Data><Devices><ECM><Early Diagnosis><Encapsulated><Encephalon><Endosomes><Endothelial Cells><Engineering><Ensure><Environment><Evaluation><Exhibits><Extracellular Matrix><Extracellular Space><Formulation><Gadolinium><Gd element><Goals><High Throughput Assay><In Vitro><Intercellular Space><Intracellular Communication and Signaling><Label><Lytotoxicity><MR Imaging><MR Tomography><MRI><MRI Scans><MRIs><MUC-1><MUC1><MUC1 gene product><Macrophage><Magnetic Resonance Imaging><Magnetic Resonance Imaging Scan><Malignant><Malignant - descriptor><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Mammary Gland Parenchyma><Mammary Gland Tissue><Mammogram><Mammography><Medical Care Costs><Medical Imaging><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medical Waste><Metals><Methods><Mice><Mice Mammals><Microfluidic Device><Microfluidic Lab-On-A-Chip><Microfluidic Microchips><Microfluidics><Mn3O4><Modeling><Muc1 Mucin><Mucin 1><Mucin 1 protein><Murine><Mus><Mφ><NMR Imaging><NMR Tomography><Normal Tissue><Normal tissue morphology><Nuclear Magnetic Resonance Imaging><Outcome><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Peptides><Performance><Perfusion><Physiologic><Physiological><Public Health><Radiopaque Media><Receptosomes><Research><Resolution><Safety><Science><Screening procedure><Signal Transduction><Signal Transduction Systems><Signaling><Skin><Specificity><Testing><Time><Toxic effect><Toxicities><Training><Tumor Cell><Universities><West Virginia><Work><Zeugmatography><active followup><adolescent woman><adolescent women><biological signal transduction><bone><breast cancer diagnosis><breast tumor cell><cancer cell><cell culture><cell cultures><cell growth><chelation><cytotoxicity><density><early detection><follow up><follow-up><followed up><followup><hausmannite><high throughput screening><imaging agent><imaging detection><imaging-based detection><imaging-based disease detection><improved><in vivo><innovate><innovation><innovative><malignancy><malignant breast neoplasm><malignant breast tumor><mammary cancer detection><mammary screening><mammographic Imaging><mammographic examinations><mammographic exams><manganese oxide><manganous-manganic oxide><medical costs><microdevice><microfabricated device><microfluidic chip><nano><nano materials><nanomaterials><neoplasm/cancer><neoplastic cell><novel><optic imaging><optical imaging><orthotopic breast adenocarcinoma><orthotopic breast cancer><orthotopic breast carcinoma><orthotopic breast tumor><overexpress><overexpression><particle><patient oriented outcomes><portability><pre-clinical development><pre-clinical study><preclinical development><preclinical study><recruit><resolutions><screening tools><supplemental screening><three dimensional><tumor><undergrad><undergraduate><undergraduate student><uptake><vascular><young woman><µfluidic>
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Elizabeth Anne McCullagh

OKLAHOMA STATE UNIVERSITY STILLWATER, STILLWATER, OK

Exploratory lead · 20/100
Solid budget
Active award
$444,238
FY 2025

Project Title

Myelination Deficits Underlying Auditory Issues in Fragile X Syndrome

Grant Number:

2R15HD105231-02A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/9/2021

End Date:

7/31/2028

Project Abstract

Autism spectrum disorder (ASD) is characterized by an inability to function in environments with multiple competing sound sources, such as a noisy classroom. These auditory issues likely originate early in sound location processing that occurs in the brainstem. The projections that make up the audit...

Research Terms

<ASD><Acoustics><Address><Affect><Allelism Test><Anatomic Sites><Anatomic structures><Anatomy><Animal Testing><Animals><Area><Auditory><Auditory Brainstem Responses><Auditory system><Autism><Autistic Disorder><Axon><Basic Research><Basic Science><Behavior><Behavioral><Binaural><Biologic Models><Biological Models><Brain><Brain Nervous System><Brain Stem><Brainstem><CNS Nervous System><Cell Body><Cells><Central Nervous System><Clinical><Cochlea><Cochlear Organ><Complementation Test><Complex><Data><Demyelinations><Development><Diameter><Disease><Disorder><Disseminated Sclerosis><Dysfunction><Ear><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Encephalon><Environment><Escalante syndrome><Fiber><Fragile X><Fragile X Syndrome><Functional disorder><Funding><Genes><Genetic><Genetic Complementation Test><Glia><Glial Cells><Goals><Hearing><Hearing Disorders><Hearing Loss><Hearing problem><Hypoacuses><Hypoacusis><Infantile Autism><Injections><Investigators><Kanner's Syndrome><Knock-in><Knowledge><Kolliker's reticulum><Link><Location><LoxP-flanked allele><Martin-Bell Syndrome><Martin-Bell-Renpenning syndrome><Math><Mathematics><Measurable><Measures><Mice><Mice Mammals><Microscopy><Model System><Modeling><Multiple Sclerosis><Murine><Mus><Myelin><Myelin Basic Proteins><Myelin Sheath><NIH><National Institutes of Health><Nerve Cells><Nerve Conduction><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neural Conduction><Neural Transmission><Neuraxis><Neurocyte><Neurodevelopmental Disorder><Neuroglia><Neuroglial Cells><Neurological Development Disorder><Neuronal Transmission><Neurons><Neurophysiology / Electrophysiology><Non-neuronal cell><Nonneuronal cell><Oklahoma><Oligodendrocytes><Oligodendrocytus><Oligodendroglia><Oligodendroglia Cell><Pathway interactions><Phenotype><Physiologic><Physiological><Physiopathology><Play><Process><Proliferating><Proteins><Renpenning syndrome 2><Research Personnel><Researchers><Role><Sensory><Source><Startle Reaction><Stimulus><Students><Symptoms><Synaptic Transmission><Testing><Therapeutic Intervention><Thick><Thickness><Time><Training><Trans Test><United States National Institutes of Health><Universities><Viral><Viral Vector><Virus><Work><X-linked mental deficiency-megalotestes syndrome><X-linked mental retardation with fragile X syndrome><X-linked mental retardation-fragile site 1 syndrome><auditory disease><auditory disorder><auditory dysfunction><auditory problem><auditory stimulus><autism spectral disorder><autism spectrum disorder><autism-fragile X (AFRAX) syndrome><autistic spectrum disorder><axon signaling><axon-glial signaling><axonal signaling><behavior measurement><behavioral measure><behavioral measurement><binaural clusters><binaural hearing><cell type><compare to control><comparison control><complementation analysis><complementation approach><conditional knock-out><conditional knockout><critical period><demyelinate><developmental><dysfunctional hearing><electrophysiological><experiment><experimental research><experimental study><experiments><floxed><floxed allele><fra(X) syndrome><fra(X)(28) syndrome><fra(X)(q27) syndrome><fra(X)(q27-28) syndrome><fragile X-mental retardation syndrome><fragile Xq syndrome><fragile site mental retardation 1><fully-deleted adenoviral vector><fully-deleted adenovirus vector><genetic approach><genetic strategy><glia signaling><glial signaling><gutless adenoviral vector><gutless adenovirus vector><gutted adenoviral vector><gutted adenovirus vector><hdAd><hearing challenged><hearing defect><hearing deficient><hearing deficit><hearing difficulty><hearing disease><hearing dysfunction><hearing impairment><helper-dependent adenoviral vector><helper-dependent adenovirus vector><insular sclerosis><interest><intervention therapy><knockin><mRNP><macro-orchidism-marker X (MOMX) syndrome><macro-orchidism-marker X syndrome><mar(X) syndrome><marker X syndrome><mental retardation-macroorchidism syndrome><messenger ribonucleoprotein><mouse model><murine model><myelination><nerve cement><nerve signaling><neural signaling><neurodevelopmental disease><neuronal><neuronal signaling><neurotransmission><novel><pathophysiology><pathway><postnatal><prepulse inhibition><programs><recruit><response><sensory system><social role><sound><startle response><tool><undergrad><undergraduate><undergraduate student>
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A.R.M. Ruhul Amin

MARSHALL UNIVERSITY, Huntington, WV

Exploratory lead · 20/100
Solid budget
Active award
$444,000
FY 2023

Project Title

Targeting oncogenic pathways for chemoprevention of head and neck cancer by FLLL12

Grant Number:

1R15DE032063-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2023

End Date:

7/31/2026

Project Abstract

PROJECT SUMMARY The delay or prevent the progression of premalignant lesions to invasive cancer by chemoprevention of squamous cell carcinoma of head and neck (SCCHN) is a devastating disease with significant morbidity and mortality. This research will investigate the use of FLLL12, a compound struc...

Research Terms

<AKT><AKT1><AKT1 gene><Affect><Akt protein><Animal Model><Animal Models and Related Studies><Assay><Award><Basal Transcription Factor><Basal transcription factor genes><Binding><Binding Sites><Bioassay><Biologic Assays><Biological Assay><Biological Markers><Body Tissues><Cancer Biology><Cancer Causing Agents><Cancer Induction><Cancer Model><Cancer cell line><CancerModel><Cancers><Carcinogens><Cell Body><Cell Communication and Signaling><Cell Culture Techniques><Cell Death><Cell Line><Cell Signaling><Cell Survival><Cell Viability><Cell-Free System><CellLine><Cellfree System><Cells><Cellular Expansion><Cellular Growth><ChIP assay><Chemoprevention><Chemopreventive><Chemopreventive Agent><Combining Site><Curcumin><Data><Deletion Mutation><Diferuloylmethane><Disease><Disorder><Drug Kinetics><Drug Targeting><EGF Receptor><EGFR><EGFR inhibition><ERBB Protein><Effectiveness><Epidermal Growth Factor Receptor><Epidermal Growth Factor Receptor Kinase><Epidermal Growth Factor Receptor Protein-Tyrosine Kinase><Epidermal Growth Factor-Urogastrone Receptors><Epidermoid Cell Cancer><FK506 Binding Protein 12-Rapamycin Associated Protein 1><FKBP12 Rapamycin Complex Associated Protein 1><FRAP1><FRAP1 gene><FRAP2><Faculty><Future><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Genes><Genetic Transcription><Goals><Grant><Growth><HER1><HNSCC><Head and Neck Carcinoma><Head and Neck Squamous Cell Carcinoma><Histologic><Histologically><Human><In Vitro><Incidence><Intracellular Communication and Signaling><JAK kinase><JAK-2><JAK2><JAK2 gene><JAK2 protein><Janus kinase><Janus kinase 2><Kinases><Lesion><Lip and Oral Cavity Neoplasm><Lip and Oral Cavity Tumour><Malignant Cell><Malignant Epidermoid Cell Neoplasm><Malignant Epidermoid Cell Tumor><Malignant Neoplasms><Malignant Oral Cavity Neoplasm><Malignant Oral Cavity Tumor><Malignant Oral Neoplasm><Malignant Squamous Cell Neoplasm><Malignant Squamous Cell Tumor><Malignant Tumor><Measures><Mechanistic Target of Rapamycin><Mediating><Methods><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Molecular Interaction><Morbidity><Morbidity - disease rate><Mouth Cancer><Mouth Neoplasms><Mouth Tumor><Murine><Mus><Natural Compound><Normal Cell><Oncogenic><Oncogens><Oral><Oral Cancer><Oral Cavity Neoplasm><Oral Cavity Tumor><Oral Neoplasms><Oral Tumor><Outcome><PRKBA><Pathway interactions><Pharmacokinetics><Phosphorylation Inhibition><Phosphotransferase Gene><Phosphotransferases><Plasmids><Precancerous Cells><Premalignant Cell><Prevention><Process><Promoter Regions><Promotor Regions><Protein Kinase B><Proto-Oncogene Proteins c-akt><RAC-ALPHA><RAC-ALPHA Gene><RAC-PK protein><RAC-PK-Alpha><RAFT1><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Reactive Site><Regulation><Reporter><Research><Resistance><Risk Reduction><Role><SCCHN><STAT3><STAT3 gene><Signal Pathway><Signal Transduction><Signal Transduction Pathway><Signal Transduction Systems><Signaling><Squamous Cell Cancers><Strains Cell Lines><TGF-alpha Receptor><Testing><Tissue Growth><Tissues><Tobacco><Transcript><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transforming Growth Factor alpha Receptor><Transphosphorylases><Treatment Protocols><Treatment Regimen><Treatment Schedule><Turmeric Yellow><Tyrosine-Protein Kinase JAK2><Urogastrone Receptor><Writing><Xenograft Model><analog><anti-carcinogenic><anticarcinogenic><bio-markers><biologic marker><biological signal transduction><biomarker><c-akt protein><c-erbB-1><c-erbB-1 Protein><cancer cell><cancer chemoprevention><cancer invasiveness><carcinogenesis><cell culture><cell cultures><cell growth><chemical carcinogen><chemoprevention agent><chemotherapeutic agent><chromatin immunoprecipitation><clinical development><constitutive expression><constitutive gene expression><cultured cell line><differential expression><differentially expressed><effective therapy><effective treatment><erbB-1><erbB-1 Proto-Oncogene Protein><erbBl><experiment><experimental research><experimental study><experiments><genetic promoter element><genetic promoter sequence><graduate student><head and neck cancer prevention><head and neck squamous carcinoma><head and neck squamous cell cancer><improved><in vivo><interdisciplinary collaboration><mRNA Expression><mTOR><malignancy><malignant mouth neoplasm><malignant mouth tumor><mammalian target of rapamycin><member><meter><model of animal><mortality><mouse model><murine model><naturally occurring compound><necrocytosis><neoplasm/cancer><novel><oncogenic agent><ontogeny><oral carcinogenesis><oral cavity cancer><oral neoplasia><overexpress><overexpression><pathway><pharmacologic><pre-clinical development><precancer><precancerous><preclinical development><premalignant><prevent><preventing><promoter><promoter sequence><promotor><proto-oncogene protein RAC><proto-oncogene protein akt><proto-oncogene protein c-erbB-1><rac protein kinase><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><related to A and C-protein><resistant><risk-reducing><social role><training opportunity><transcription factor><transcriptional differences><transcriptome sequencing><transcriptomic sequencing><transdisciplinary collaboration><tumor growth><undergrad><undergraduate><undergraduate student><xenograft transplant model><xenotransplant model>
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Ronald Blake Cox

OKLAHOMA STATE UNIVERSITY STILLWATER, STILLWATER, OK

Exploratory lead · 20/100
Solid budget
Active award
$443,317
FY 2023

Project Title

Randomized Control Trial of the Co-Parenting for Resilience Program

Grant Number:

1R15HD112895-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/18/2023

End Date:

8/31/2026

Project Abstract

Project Summary Parental divorce can negatively affect children in ways that are often severe and long lasting. Approximately 25% of the children of divorcing parents have major long-term mental and behavioral health problems compared to approximately only 10% of children in the general population. ...

Research Terms

<0-11 years old><10 year old><10 years of age><Academic Research Enhancement Awards><Active Follow-up><Address><Age><Alcohol Chemical Class><Alcohols><Attention><Behavioral><Bibliotherapy><Books><COVID-19><COVID19><CV-19><CV19><Child><Child Rearing><Child Youth><Children (0-21)><Cognition><Collaborations><Competence><Conflict><Conflict (Psychology)><Control Groups><County><Coupled><Couples><Data><Diagnosis><Disease remission><Divorce><Divorced state><Drugs><Education><Educational aspects><Educational process of instructing><Educational workshop><Effectiveness><Emotional><Emotions><Ethnic Origin><Ethnicity><Exposure to><Family><Family Research><Family Therapy><Family psychotherapy><Foundations><Gender><General Population><General Public><Hour><Individual><Institution><Instruction><Intervention><Intervention Strategies><Knowledge><Marriage and Family><Mediating><Mediation><Medication><Mental Depression><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Methodology><Negotiating><Negotiation><Oklahoma><Outcome><Parenting><Parenting behavior><Parents><Participant><Performance><Persons><Pharmaceutic Preparations><Pharmaceutical Preparations><Phase><Pilot Projects><Placebo Control><Prevention><Process><Program Development><Program Evaluation><Proliferating><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Public Health><Quasi-experiment><Quasi-experimental analysis><Quasi-experimental approach><Quasi-experimental design><Quasi-experimental methods><Quasi-experimental research><Quasi-experimental study><Quasi-experimental technique><R-Series Research Projects><R01 Mechanism><R01 Program><R15 Mechanism><R15 Program><Randomized><Randomized, Controlled Trials><Reading><Remission><Reporting><Research><Research Grants><Research Project Grants><Research Projects><Rural Population><Rural group><Rural people><Sampling><School Drop-Outs><School Dropouts><Science><Sex Behavior><Sexual Activity><Sexual Behavior><Stress><Student Dropouts><Subgroup><System><Teaching><Testing><Therapeutic><Workshop><active followup><age 10 years><ages><antisocial behavior><arm><behavior change><behavioral health><brief prevention intervention><brief preventive intervention><childrearing><coping><corona virus disease 2019><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><cost><court><deep learning><delivered on-line><delivered online><depression><design><designing><drug/agent><emotional distress><experience><feeling distress><feeling upset><field theory><follow up><follow-up><followed up><followup><graduate student><improved><innovate><innovation><innovative><insight><interventional strategy><kids><mental illness><motivational enhancement therapy><motivational interview><negative affect><negative affectivity><on-line delivery><online delivery><online version><parent><peer><physical conditioning><physical health><pilot study><placebo controlled><programs><psychiatric illness><psychoeducation><psychoeducational><psychoeducational intervention><psychological disorder><randomisation><randomization><randomized control trial><randomly assigned><resilience><resilient><response><rural individual><rural under served><rural underserved><sex activity><sexual activities><social><substance use><substance using><ten year old><ten years of age><theories><undergrad><undergraduate><undergraduate student><web based delivery><youngster>
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ZUI PAN

UNIVERSITY OF TEXAS ARLINGTON, ARLINGTON, TX

Exploratory lead · 20/100
Solid budget
Active award
$443,022
FY 2023

Project Title

Zinc Protection Against Ischemia-Reperfusion Injury in Heart

Grant Number:

1R15HL168628-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2023

End Date:

6/30/2026

Project Abstract

Project Summary This project is aimed to provide NIH R15 REAP research opportunities for our underrepresented graduate students at UT Arlington, a Hispanic-Serving Institute in North Texas. During acute ischemia-reperfusion (I/R), reactive oxygen species (ROS) is generated at the reperfusion phase a...

Research Terms

<Active Oxygen><Acute><Address><Antioxidants><Apoplexy><Apoptosis><Apoptosis Pathway><Area><Autoregulation><Award><Biochemistry><Biological Chemistry><Body Tissues><Brain Vascular Accident><CRISPR approach><CRISPR based approach><CRISPR editing screen><CRISPR method><CRISPR methodology><CRISPR screen><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based screen><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 screen><CRISPR/Cas9 technology><Cardiac><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Cardiomyopathies><Cardiovascular Physiology><Cas nuclease technology><Cell Body><Cell Death><Cell Survival><Cell Viability><Cell membrane><Cells><Cellular Regulation><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Clinical Trials><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Confocal Microscopy><Cytoplasmic Membrane><Data><Doctor of Philosophy><EFRAC><Echocardiogram><Echocardiography><Ejection Fraction><Formulation><Gene Transcription><Generalized Growth><Genes><Genetic><Genetic Transcription><Goals><Growth><Health><Heart><Heart Muscle Cells><Heart failure><Heart myocyte><Hispanic><Homeostasis><Human><Hypoxia><Hypoxic><Immunoblotting><Individual><Infarction><Inflammation><Injury><Intermediary Metabolism><Ionophores><Ischemia><Ischemia-Reperfusion Injury><Ischemic Heart><Ischemic Heart Disease><Ischemic myocardium><Laboratories><Left Ventricles><Left ventricular structure><Link><Mammalian Cell><Mediating><Membrane><Metabolic Processes><Metabolism><Metallothionein><Methods><Mice><Mice Mammals><Minority><Modern Man><Molecular><Monitor><Murine><Mus><Muscle><Muscle Cells><Muscle Tissue><Myocardial Diseases><Myocardial Disorder><Myocardial Ischemia><Myocardial depression><Myocardial dysfunction><Myocardiopathies><Myocytes><NIH><Na element><National Institutes of Health><Natural regeneration><Necrosis><Necrotic><Nutrient><Osmolar Concentration><Osmolarity><Oxidative Stress><Oxygen Deficiency><Oxygen Radicals><Perfusion><Ph D student><Ph D. student><Ph. D. student><Ph.D student><Ph.D.><Ph.D. student><PhD><PhD student><PhD. student><Phase><Phlorhizin><Phloridzin><Phlorizin><Physiological Homeostasis><Plasma Membrane><Pro-Oxidants><Programmed Cell Death><Proteins><Quantitative RTPCR><Quantitative Reverse Transcriptase PCR><RNA Expression><Reactive Oxygen Species><Regeneration><Regimen><Regulation><Reperfusion Damage><Reperfusion Injury><Reperfusion Therapy><Reporting><Research><Research Resources><Resources><Risk><Role><Sarcolemma><Signal Pathway><Sodium><Stroke><Students><Supplementation with zinc><Techniques><Testing><Texas><Therapeutic><Tissue Growth><Tissues><Toxic effect><Toxicities><Training><Transcription><Transthoracic Echocardiography><United States National Institutes of Health><Validation><Western Blotting><Western Immunoblotting><Zinc><Zinc supplementation><Zn element><Zn supplementation><after stroke><anti-oxidant><bone><brain attack><candidate validation><cardiac damage><cardiac dysfunction><cardiac failure><cardiac ischemia><cardiomyocyte><cardioprotectant><cardioprotection><cardioprotective><cardiovascular function><career><cell growth regulation><cerebral vascular accident><cerebrovascular accident><clustered regularly interspaced short palindromic repeats screen><college><collegiate><conditioning><coronary ischemia><doctoral student><dosage><entire genome><full genome><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><genome scale><genome-wide><genomewide><graduate student><heart damage><heart dysfunction><heart ischemia><heart sonography><in vivo><infarct><inhibitor><injuries><innovate><innovation><innovative><knock-down><knockdown><member><membrane structure><muscular><myocardial ischemia/hypoxia><myocardium disease><myocardium disorder><myocardium ischemia><myoinositol><necrocytosis><ontogeny><overexpress><overexpression><pharmacologic><plasmalemma><post stroke><poststroke><prevent><preventing><programs><protective effect><protein blotting><qRTPCR><regenerate><reperfusion><reverse genetics><screening><screenings><side effect><social role><stroked><strokes><temporal measurement><temporal resolution><time measurement><undergrad><undergraduate><undergraduate student><validations><whole genome><zinc binding ligand><zinc supplement><zinc transporter><zinc-binding protein>
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Andre Khalil

UNIVERSITY OF MAINE ORONO, ORONO, ME

Exploratory lead · 20/100
Solid budget
Active award
$440,561
FY 2025

Project Title

Multiscale anisotropy analysis of breast tissue subtypes from mammography and pathology

Grant Number:

2R15CA246335-02

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/7/2020

End Date:

1/31/2028

Project Abstract

Summary Half of breast cancer cases occur in women with no identifiable risk factors. Approximately 50% of women have dense breasts, which increases their risk 3-5 fold compared to those with entirely fatty breasts, but only a subset of them will develop breast cancer. One explanation lies in tumor ...

Research Terms

<Address><Anisotropy><Area><Benign><Biological Markers><Biomedical Engineering><Biomedical Research><Body Tissues><Breast><Breast Cancer><Breast Cancer Risk Factor><Breast Tissue><Cancer Patient><Cancers><Carcinoma><Clinical><Collagen><Collagen Fiber><Communities><Complement><Complement Proteins><Computational Technique><Computer Software Development><Computer Software Engineering><Computer software><Computing Methodologies><DCIS><Data Bases><Data Set><Databases><Diagnosis><Diagnostic><Disease><Disorder><Distal><Duct><Duct (organ) structure><Ductal Breast Carcinoma In Situ><Ductal Carcinoma In Situ><Ductal Hyperplasia><Education><Educational aspects><Environment><Epithelial cancer><Faculty><Funding><General Radiology><Goals><Grant><Histology><Image><International><Internships><Intraductal Carcinoma><Intraductal Carcinoma of the Breast><Intraductal Hyperplasia><Legal patent><Licensing><Link><Location><Maine><Malignant Breast Neoplasm><Malignant Epithelial Neoplasms><Malignant Epithelial Tumors><Malignant Melanoma><Malignant Neoplasms><Malignant Pancreatic Neoplasm><Malignant Tumor><Malignant neoplasm of pancreas><Mammary Gland Parenchyma><Mammary Gland Tissue><Mammogram><Mammographic Density><Mammography><Manuscripts><Math><Mathematics><Measurement><Measures><Medical><Medical Research><Melanoma><Modeling><Nature><Non-Infiltrating Ductal Breast Adenocarcinoma><Non-Infiltrating Ductal Carcinoma of the Breast><Non-Infiltrating Intraductal Adenocarcinoma><Non-Infiltrating Intraductal Breast Adenocarcinoma><Non-Invasive Ductal Breast Adenocarcinoma><Non-Invasive Ductal Carcinoma of the Breast><Non-Invasive Intraductal Breast Adenocarcinoma><Noninfiltrating Intraductal Carcinoma><North America><Outcome><Pancreas Cancer><Pancreatic Cancer><Patents><Pathologic><Pathology><Performance><Play><Position><Positioning Attribute><Predicting Risk><Printing><Probabilistic Models><Probability Models><Publications><Publishing><ROC Analyses><ROC Curve><Radiology><Radiology Specialty><Regional Cancer><Research><Research Institute><Risk><Risk Assessment><Risk Factors><Role><Scientific Publication><Slide><Societies><Software><Software Engineering><Statistical Models><Structure><Students><Techniques><Testing><Texture><Tissues><Tumor Cell Invasion><Tumor Invasion><Tumor Subtype><Universities><Woman><Work><bio-engineered><bio-engineers><bio-markers><bioengineering><biologic marker><biological engineering><biomarker><breast cancer risk><cancer microenvironment><cancer risk><career development><career preparation><career readiness><clinical care partner><commercialization><complementation><computational methodology><computational methods><computer based method><computer methods><computing method><conference><convention><data base><epithelial carcinoma><forecasting risk><healthcare partner><imaging><improved><innovate><innovation><innovative><intern><job readiness><longitudinal database><malignancy><malignant breast tumor><mammographic Imaging><mammographic breast density><mammographic examinations><mammographic exams><meeting><meetings><neoplasm/cancer><new approaches><novel><novel approaches><novel strategies><novel strategy><open source><pancreatic malignancy><patient population><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><posters><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive risk><predicts risk><professor><programs><receiver operating characteristic analyses><receiver operating characteristic curve><risk prediction><risk predictions><screening><screenings><segregation><social role><statistical linear mixed models><statistical linear models><statistics><summit><symposia><symposium><tumor><tumor microenvironment><tumorigenic><undergrad><undergraduate><undergraduate student><user-friendly><whole slide imaging><work readiness><workforce readiness><workplace readiness>
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Ayorkor Gaba

COLUMBIA UNIVERSITY TEACHERS COLLEGE, NEW YORK, NY

Exploratory lead · 20/100
Solid budget
Active award
$440,445
FY 2023

Project Title

Prospection in suicidal teens: Identifying a novel and malleable cognitive risk factor

Grant Number:

2R15MH113076-02A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2018

End Date:

1/31/2027

Project Abstract

PROJECT SUMMARY Suicidal ideation is an immensely distressing experience that often emerges in adolescence, recurs over time, and is difficult to treat. It is also one of the most potent risk factors for subsequent suicide attempt and death. Reducing suicidal ideation among adolescents may not only ...

Research Terms

<12-20 years old><Address><Adolescence><Adolescent><Adolescent Youth><Affect><Affective><Area><Causality><Cessation of life><Clinical><Cognition><Cognitive><Data><Death><Development><Distress><Ecological momentary assessment><Etiology><Event><Feeling suicidal><Future><Generalized Growth><Goals><Growth><History><Hour><Intervention><Intervention Strategies><Knowledge><Laboratories><Life><Link><Longitudinal Studies><Measures><Mental Depression><Pattern><Position><Positioning Attribute><Public Health><Recording of previous events><Recurrence><Recurrent><Research><Risk Factors><Role><Sampling><Severities><Specific qualifier value><Specificity><Specified><Suicidal thoughts><Suicide><Suicide attempt><Teen><Teenagers><Testing><Thinking><Time><Tissue Growth><Work><Youth><Youth 10-21><adolescence (12-20)><causation><clinical care><clinical significance><clinically significant><cognitive process><depression><design><designing><developmental><disease causation><experience><fatal attempt><fatal suicide><histories><improved><innovate><innovation><innovative><insight><intent to die><intervention design><interventional strategy><juvenile><juvenile human><long-term study><longitudinal outcome studies><longterm study><negative affect><negative affectivity><neglect><non fatal attempt><nonfatal attempt><novel><ontogeny><preempt><prevent><preventing><psychologic><psychological><reduce suicidality><reduce suicide><reducing suicidality><reducing suicide><response><social role><spatiotemporal><standard care><standard treatment><suicidal><suicidal adolescent><suicidal adolescents><suicidal attempt><suicidal behavior><suicidal ideation><suicidal individual><suicidal morbidity><suicidal risk><suicidal thinking><suicidal youth><suicidal youths><suicidality><suicide behavior><suicide death><suicide ideation><suicide morbidity><suicide risk><suicides><teen years><teenage><theories><therapy design><thoughts><thoughts about suicide><treatment design>
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Sang Hoon Rhee

OAKLAND UNIVERSITY, ROCHESTER, MI

Exploratory lead · 20/100
Solid budget
Active award
$439,049
FY 2025

Project Title

PTEN and gut epithelial physiology

Grant Number:

1R15CA297583-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2025

End Date:

6/30/2028

Project Abstract

Project Summary PTEN is classically considered a lipid phosphatase. Hence, loss of PTEN perpetuates the PI3K-Akt signaling to promote cell proliferation, causing pre-clinical dysplasia or tumor. On the other hand, emerging evidence suggests that PTEN has a protein phosphatase activity to regulate th...

Research Terms

<1-Phosphatidylinositol 3-Kinase><AKT Signaling Pathway><APF-1><ATP-Dependent Proteolysis Factor 1><Abnormal Cell><Applications Grants><Autophagocytosis><Autophagosome><Binding><Body Tissues><Cell Body><Cell Communication and Signaling><Cell Growth in Number><Cell Isolation><Cell Junctions><Cell Locomotion><Cell Migration><Cell Movement><Cell Multiplication><Cell Proliferation><Cell Segregation><Cell Separation><Cell Separation Technology><Cell Signaling><Cells><Cellular Expansion><Cellular Growth><Cellular Migration><Cellular Motility><Cellular Proliferation><Chiro-Inositol><Colon Cancer><Colon Carcinoma><Development><Dysplasia><Epithelial Cells><Epithelial Physiology><Exhibits><Genes><Grant Proposals><Gut Epithelium><HMG-20><High Mobility Protein 20><Human><Immune><Immune Regulators><Immune Surveillance><Immunes><Immunologic Surveillance><Immunomodulators><Immunosurveillance><Inositol><Intercellular Junctions><Intervention><Intestinal><Intestinal Leakage><Intestinal Neoplasia><Intestinal Neoplasms><Intestinal Tumor><Intestines><Intestines Neoplasms><Intracellular Communication and Signaling><Knock-out><Knockout><Leaky Gut><Lipids><Lysosomes><MMAC1><MMAC1 protein><Measures><Mediating><Mesoinositol><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Mice><Mice Mammals><Modern Man><Molecular Interaction><Murine><Mus><Mutated in Multiple Advanced Cancers 1><Neoplasm Metastasis><Normal Tissue><Normal tissue morphology><Oncogenesis><Organ><PHTS gene><PHTS protein><PI-3 Kinase><PI3-Kinase><PI3CG><PI3KGamma><PI3k><PIK3><PIK3CG><PIK3CG gene><PTEN><PTEN gene><PTEN protein><PTEN1><Pathway interactions><Phosphatase and Tensin Homolog><Phosphatase and Tensin Homolog Deleted on Chromosome 10><Phosphatases><Phosphatidylinositol 3-Kinase><Phosphatidylinositol-3-OH Kinase><Phosphohydrolases><Phosphoinositide 3-Hydroxykinase><Phosphomonoesterases><Phosphoprotein Phosphatase><Phosphoprotein Phosphatase-2C><Phosphoprotein Phosphohydrolase><Phosphoric Monoester Hydrolases><Phosphorylation><Protein Phosphatase C><Protein Phosphatase Gene><Protein Phosphatase-1><Protein Phosphatase-2A><Protein Phosphorylation><Protein phosphatase><Proteins><PtdIns 3-Kinase><Public Health><Repression><Repressor Proteins><Research><Role><Secondary Neoplasm><Secondary Tumor><Signal Transduction><Signal Transduction Systems><Signaling><Snails><Testing><Tissues><Transcription Repressor><Transcriptional Repressor><Type I Phosphatidylinositol Kinase><Type III Phosphoinositide 3-Kinase><Ubiquitilation><Ubiquitin><Ubiquitination><Ubiquitinoylation><autophagy><biological signal transduction><bowel><cancer in the colon><cancer metastasis><cell growth><cell motility><cell sorting><developmental><dyscrasia><gastrointestinal epithelium><genetic repressor><immune modulators><immunomodulatory molecules><immunoregulator><immunoregulatory molecules><inhibitor><intestinal epithelium><mutated in multiple advanced cancers 1 protein><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathway><phosphatase and tensin homologue on chromosome ten><pre-clinical><preclinical><preservation><prevent><preventing><protein expression><repressor complex><restraint><segregation><slug><small molecule><social role><tumor><tumor cell metastasis><tumorigenesis><tumorigenic><ubiquination><ubiquitin conjugation>
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Sadagopan Krishnan

OKLAHOMA STATE UNIVERSITY STILLWATER, STILLWATER, OK

Exploratory lead · 20/100
Solid budget
Active award
$438,878
FY 2023

Project Title

Multiplex Hybridization Colorimetric Sensor for Wild Type and Variant RNA Biomarkers

Grant Number:

1R15EB034037-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/11/2023

End Date:

6/30/2026

Project Abstract

Laboratory-based assays such as reverse transcriptase-polymerase chain reaction (RT-PCR) of respiratory secretions are being used routinely to detect viral nucleic acids. The RT-PCR assay, however, has many limitations such as the need for high purity samples, gene isolation and amplification, highl...

Research Terms

<2019 novel corona virus><2019 novel coronavirus><2019-nCoV><Amides><Amines><Assay><Base Pairing><Binding><Bioassay><Biologic Assays><Biologic Models><Biological Assay><Biological Markers><Biological Models><Biomedical Engineering><Biomedical Research><Biotin><Biotinylation><Blood Serum><COVID><COVID-19><COVID-19 detection><COVID-19 virus><COVID19><COVID19 detection><COVID19 virus><CV-19><CV19><Calibration><Carbodiimides><Carboxylic Acids><Cell Communication and Signaling><Cell Signaling><Chemicals><Chemistry><CoV disease><CoV-2><CoV2><Color><Complex><D-Glucose><DNA><Deoxyribonucleic Acid><Detection><Dextrose><Diagnosis><Disease><Disorder><Educational process of instructing><Endocrine Gland Secretion><Environment><Exposure to><Fe oxide><Genes><Genetic Alteration><Genetic Change><Genetic defect><Glucose><Goals><Gold><H2O2><Hemi-Myeloperoxidase><Hormones><Human Resources><Hydrogen Peroxide><Hydroperoxide><Immobilization><Infection><Intracellular Communication and Signaling><Ions><Label><Laboratories><Lateral><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Magnetism><Manpower><Measurement><Measures><Mercaptans><Mercapto Compounds><Metals><Methods><Model System><Molecular><Molecular Interaction><Mutation><Myeloperoxidase><Non-Polyadenylated RNA><Nucleic Acids><Nucleotides><Oklahoma><Oligo><Oligonucleotide Probes><Oligonucleotides><Outcome><Output><Paper><Pathogenicity><Peroxidases><Polymerase Chain Reaction><Population><Probability><Process><Prognosis><RNA><RNA Gene Products><RNA marker><ROC Analyses><ROC Curve><RT-PCR><RTPCR><Reagent><Research><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Reverse Transcriptase Polymerase Chain Reaction><Ribonucleic Acid><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 detection><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Saliva><Sampling><Schools><Sensitivity and Specificity><Serum><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Signal Transduction><Signal Transduction Systems><Signaling><Strepavidin><Streptavidin><Sulfhydryl Compounds><Surface><Teaching><Techniques><Technology><Testing><Therapeutic Hormone><Thiols><Training><Translations><Universities><Validation><Variant><Variation><Viral Burden><Viral Diseases><Viral Load><Viral Load result><Virus><Virus Diseases><Visual><Vitamin H><Wuhan coronavirus><amine><amplification and detection><amplification detection><bio-engineered><bio-engineers><bio-markers><bioengineering><biologic marker><biological engineering><biological signal transduction><biomarker><coenzyme R><colcothar><combat><corona virus disease><corona virus disease 2019><coronavirus disease><coronavirus disease 2019><coronavirus disease 2019 detection><coronavirus disease 2019 virus><coronavirus disease-19><coronavirus disease-19 virus><coronavirus infectious disease-19><cost><design><designing><detect COVID-19><detect COVID19><detect SARS-CoV-2><detect severe acute respiratory syndrome coronavirus 2><detection limit><detection of amplification><detection sensitivity><detector><disease diagnosis><experience><ferric oxide><genome mutation><gold nano particle><gold nanoparticle><hCoV19><innovate><innovation><innovative><instrument><iron oxide><magnetic><minimally invasive><molecular diagnostics><nCoV2><nano><nano gold><nano materials><nano particle><nano shell><nano-sized particle><nanoGold><nanomaterials><nanoparticle><nanoshell><nanosized particle><new approaches><novel approaches><novel strategies><novel strategy><oligos><orthopedic freezing><pandemic><pandemic disease><personnel><plasmonics><public health relevance><receiver operating characteristic analyses><receiver operating characteristic curve><red iron oxide><respiratory><reverse transcriptase PCR><sensor><severe acute respiratory syndrome coronavirus 2 detection><specific biomarkers><sulfhydryl group><targeted biomarker><translation><undergrad><undergraduate><undergraduate student><validations><variant detection><viral RNA><viral detection><viral infection><virus RNA><virus detection><virus infection><virus-induced disease>
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Perla B. Gamez

LOYOLA UNIVERSITY OF CHICAGO, CHICAGO, IL

Exploratory lead · 20/100
Solid budget
Active award
$436,088
FY 2023

Project Title

Spanish-speaking Latinos' Early Language Environments and Dual Language Development

Grant Number:

2R15HD097589-02

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/24/2019

End Date:

7/31/2026

Project Abstract

PROJECT SUMMARY Bilingually exposed Latino students are often characterized as being at-risk for reading difficulties, despite there being two possible language pathways toward successful reading for bilinguals. Heightened economic hardship accounts for such academic difficulties as do the socioling...

Research Terms

<0-11 years old><ANOVA><Academic achievement><Active Follow-up><Age><Agreement><Analysis of Variance><Behavior><Buffers><Calibration><Care Givers><Caregivers><Child><Child Language><Child Youth><Children (0-21)><Code><Coding System><Data><Dependence><Development><Economics><Education><Educational aspects><Environment><Experimental Designs><Exposure to><Fathers><Fostering><Funding Mechanisms><Future><Gene Transcription><Generalized Growth><Genetic Transcription><Gestures><Goals><Grain><Growth><Health><Home><Intervention><Intervention Strategies><Interview><Investigators><Language><Language Development><Latino><Latino Population><Latino group><Latino individual><Latino people><Latinos><Lead><Learning><Life><Linguistic><Linguistics><Logistic Regressions><Measures><Methods><Modeling><Mothers><Nature><Outcome><Output><Pathway interactions><Pb element><Personal Satisfaction><Policies><Population><Process><Proxy><Publishing><Questionnaires><RNA Expression><Reading><Research><Research Personnel><Researchers><Risk><Role><Sampling><Schools><Source><Speech><Standardization><Structure><Students><Testing><Time><Tissue Growth><Training><Transact><Transcription><Variance Analyses><Vocabulary><Vocabulary Words><Work><acquiring language skills><active followup><ages><attentional control><bilingual><bilingualism><career><developmental><dynamic system><dynamical system><economic><experiment><experimental research><experimental study><experiments><follow up><follow-up><followed up><followup><grandparent><hands on research><heavy metal Pb><heavy metal lead><homes><intervention design><interventional strategy><kids><language acquisition><language learning><language outcome><lens><lenses><non-speaking><non-verbal><non-vocal><nutrition><ontogeny><pathway><primary care giver><primary caregiver><reading deficiency><reading deficit><reading difficulties><recruit><skills><social><social role><socio-linguistics><sociolinguistics><student training><success><syntactic><syntax><therapy design><treatment design><undergrad><undergraduate><undergraduate student><verbal><well-being><wellbeing><word learning><youngster>
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Kenia Pedrosa Nunes

FLORIDA INSTITUTE OF TECHNOLOGY, MELBOURNE, FL

Exploratory lead · 20/100
Solid budget
Active award
$434,178
FY 2022

Project Title

Dual Role of HSP70 in Diabetes-Induced Vascular Dysfunction

Grant Number:

1R15DK131511-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/4/2022

End Date:

7/31/2026

Project Abstract

Dual role of HSP70 in diabetes-induced vascular dysfunction R15 – Applicant Kenia Nunes Project Summary/Abstract Vascular damage, a significant health problem, is linked to hyperglycemia, a key component of both types of diabetes. The rationale for this study is that increased glucose levels chrono...

Research Terms

<(TNF)-α><70-kD Heat-Shock Protein><7S Gamma Globulin><Address><Adult-Onset Diabetes Mellitus><Affect><Agonist><Animals><Antibodies><Aorta><Atomic Force Microscopy><Automobile Driving><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Beta Proprotein Interleukin 1><Biology><Biomedical Engineering><Blood Serum><Blood Vessels><Body Tissues><Bone-Derived Transforming Growth Factor><Cachectin><Cell Adhesion><Cell Body><Cell Communication and Signaling><Cell Compartmentation><Cell Compartmentations><Cell Signaling><Cell-Extracellular Matrix><Cells><Cellular Adhesion><Chaperone><Chronology><Collaborations><Confocal Microscopy><Cultured Cells><D-Glucose><Data><Deposit><Deposition><Dextrose><Diabetes Mellitus><Disease><Disorder><Drugs><ECM><ELISA><Echography><Echotomography><Engineering><Environment><Enzyme-Linked Immunosorbent Assay><Exposure to><Extracellular Matrix><Female><Florida><Force Microscopy><Glucose><HPGF><HSP 70><HSP70><Health><Heat Production><Heat-Shock Proteins 70><Hepatocyte-Stimulating Factor><Human><Hybridoma Growth Factor><Hyperglycemia><IFN-beta 2><IFNB2><IL-1 beta><IL-1 β><IL-1-b><IL-1β><IL-6><IL1-Beta><IL1-β><IL1B Protein><IL1F2><IL1β><IL6 Protein><IP3R><IP3R1><ITPR1><ITPR1 gene><IgG><Immune system><Immunoblotting><Immunoglobulin G><In Vitro><Inflammation><Inositol 1,4,5-Triphosphate Receptor Type 1><Insp3r1><Interleukin 1beta><Interleukin-1 beta><Interleukin-1β><Interleukin-6><Intracellular Communication and Signaling><Involuntary Muscle><Ketosis-Resistant Diabetes Mellitus><Laboratories><Leiomyocyte><Link><Literature><MGI-2><Macrophage-Derived TNF><Maturity-Onset Diabetes Mellitus><Measures><Medical Ultrasound><Medication><Mesenteric><Mesentery><Methods><Mice><Mice Mammals><Milk Growth Factor><Modern Man><Molecular><Molecular Chaperones><Monocyte-Derived TNF><Murine><Mus><Myeloid Differentiation-Inducing Protein><NADPH Oxidase><NIDDM><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Outcome><Outcomes Research><Oxidative Stress><Pharmaceutic Preparations><Pharmaceutical Preparations><Pharmacology><Physiologic><Physiologic pulse><Physiological><Plasmacytoma Growth Factor><Platelet Transforming Growth Factor><Play><Preinterleukin 1 Beta><Proteins><Pulse><Research><Research Training><Rho-associated kinase><Rho-kinase><Role><Scanning Force Microscopy><Science><Serum><Severities><Short interfering RNA><Signal Transduction><Signal Transduction Systems><Signaling><Slow-Onset Diabetes Mellitus><Small Interfering RNA><Smooth Muscle><Smooth Muscle Cells><Smooth Muscle Myocytes><Smooth Muscle Tissue Cell><Source><Stable Diabetes Mellitus><Students><Supervision><T2 DM><T2D><T2DM><TGF B><TGF-beta><TGF-β><TGFbeta><TGFβ><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Techniques><Testing><Thermogenesis><Tissues><Transforming Growth Factor beta><Transforming Growth Factor-Beta Family Gene><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Ultrasonic Imaging><Ultrasonogram><Ultrasonography><Ultrasound Diagnosis><Ultrasound Medical Imaging><Ultrasound Test><Up-Regulation><Upregulation><Vascular Diseases><Vascular Disorder><Vascular Smooth Muscle><Western Blotting><Western Immunoblotting><adult onset diabetes><allergic/immunologic body system><allergic/immunologic organ system><arterial stiffening><arterial stiffness><artery stiffening><artery stiffness><base><bio-engineered><bio-engineers><bioengineering><biological engineering><biological signal transduction><blood vessel disorder><cytokine><db/db mouse><diabetes><diabetes management><diabetic management><diagnostic ultrasound><driving><drug/agent><enzyme linked immunoassay><experience><experiment><experimental research><experimental study><extracellular><hsp70 Family><hyperglycemic><in vivo><inhibitor><innovate><innovation><innovative><interferon beta 2><ketosis resistant diabetes><knock-down><knockdown><male><maturity onset diabetes><mouse model><multidisciplinary><murine model><nano meter scale><nano meter sized><nano scale><nanometer scale><nanometer sized><nanoscale><prevent><preventing><professor><protein blotting><response><sex><siRNA><social role><sonogram><sonography><sound measurement><type 2 DM><type II DM><type two diabetes><ultrasound><ultrasound imaging><ultrasound scanning><undergrad><undergraduate><undergraduate student><vascular><vascular dysfunction><vasculopathy>
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Yaorong Zheng

KENT STATE UNIVERSITY, KENT, OH

Exploratory lead · 20/100
Solid budget
Active award
$434,148
FY 2024

Project Title

Light-Controlled Supramolecular Platinum Complexes for Biomedical Applications

Grant Number:

1R15GM152919-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2027

Project Abstract

PROJECT SUMMARY Our goal in this R15 proposal is to investigate the photoreduction of Pt(IV) complexes as a new versatile approach for NIR-uncaging that can operate both in vitro and in vivo. Photo-uncaging is a technique that selectively blocks biologically relevant functional groups, enabling ext...

Research Terms

<14-Hydroxydaunomycin><Actinic Rays><Actinotherapy><Address><Adriamycine><Benign><Biochemical><Bioinorganic Chemistry><Biological><Biology><Biomedical Research><Body Tissues><CBDCA><CDDP><Carboplatin><Carboplatino><Cellular biology><Chemicals><Chemistry><Cis-diammine-dichloroplatinum><Cis-diamminedichloridoplatinum><Cis-diamminedichloro Platinum (II)><Cis-dichloroammine Platinum (II)><Cis-platinous Diamine Dichloride><Cis-platinum II><Cis-platinum II Diamine Dichloride><Cisplatin><Cisplatina><Cisplatinum><Coloring Agents><Complex><Complication><Copper><Cu element><Cysplatyna><Darkness><Data><Dedications><Development><Diagnostic><Dichlorodiammineplatinum><Doxorubicin><Doxorubicina><Drug Delivery><Drug Delivery Systems><Drug Kinetics><Drugs><Dyes><Education><Educational aspects><Electron Transport><Environment><Exhibits><Goals><Hydroxyl Daunorubicin><Hydroxyldaunorubicin><Hypoxia><Hypoxic><In Vitro><Interdisciplinary Research><Interdisciplinary Study><Ligands><Light><Light Therapy><Location><Medication><Methods><Modeling><Multidisciplinary Collaboration><Multidisciplinary Research><NIR dye><O element><O2 element><Oxygen><Oxygen Deficiency><Penetration><Peyrone's Chloride><Peyrone's Salt><Pharmaceutical Preparations><Pharmacokinetics><Photobleaching><Photoradiation><Photoradiation Therapy><Phototherapy><Phototoxicity><Platinum><Platinum Black><Platinum Diamminodichloride><Process><Property><Pt element><R-Series Research Projects><R01 Mechanism><R01 Program><Reducing Agents><Reductants><Reporter><Reporting><Research><Research Grants><Research Project Grants><Research Projects><Techniques><Technology><Testing><Therapeutic><Tissues><Training><UV light><UV radiation><UV rays><Ultraviolet Rays><Universities><anti-cancer><assess effectiveness><biologic><cell biology><chemical bond><chemical cleavage><cis dichlorodiammineplatinum><cis platinum compound><cis-Diaminedichloroplatinum><cis-Diamminedichloroplatinum><cis-Diamminedichloroplatinum(II)><cis-Dichlorodiammineplatinum(II)><cis-Platinum><design><designing><determine effectiveness><developmental><drug/agent><effectiveness assessment><effectiveness evaluation><efficacy validation><electron transfer><empowerment><evaluate effectiveness><examine effectiveness><extracellular><flexibility><flexible><fluorophore><functional group><graduate student><in vivo><innovate><innovation><innovative><insight><invention><irradiation><light intervention><light treatment><lipophilicity><luciferin><metal complex><near IR dye><near infrared dye><new approaches><novel><novel approaches><novel strategies><novel strategy><prevent><preventing><programs><recruit><scaffold><scaffolding><spatiotemporal><success><technology implementation><technology validation><tumor><tumor xenograft><ultra violet light><ultra violet radiation><ultra violet rays><ultraviolet light><ultraviolet radiation><undergrad><undergraduate><undergraduate research><undergraduate student><validate efficacy>
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Leena Panneerseelan-Bharath

MERRIMACK COLLEGE, NORTH ANDOVER, MA

Exploratory lead · 20/100
Solid budget
Active award
$433,949
FY 2025

Project Title

Mitochondrial Aging Promotes Inflammation

Grant Number:

2R15AG068957-02A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2021

End Date:

7/31/2028

Project Abstract

PROJECT SUMMARY/ABSTRACT Mitochondrial Aging Promotes Inflammation Aging is often associated with a progressive decline in health, resulting in reduced quality of life that limits health span, defined as the number of years spent in good health. Of the many cellular processes that decline with age, ...

Research Terms

<(TNF)-α><21+ years old><AD dementia><Acceleration><Adult><Adult Human><Age><Age of Onset><Age related pathologies><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Amentia><Autoimmune><Autoimmune Status><Autoimmunity><Autophagocytosis><Autoregulation><Award><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor Gene><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor 2 Gene><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF-2 Gene><BSF2><BSF2 Gene><Beta-2 Gene Interferon><Bioinformatics><Biology><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CTLA-8><CTLA-8 Gene><CTLA8><CTLA8 Gene><Cachectin><Cancers><Cardiovascular Diseases><Cell Communication and Signaling><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cellular Function><Cellular Physiology><Cellular Process><Cellular Regulation><Chronic><Communicable Diseases><Complex><Cytotoxic T-Lymphocyte-Associated Antigen 8><Cytotoxic T-Lymphocyte-Associated Antigen 8 Gene><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 Gene><Data><Dementia><Dependence><Development><Diabetes Mellitus><Disease><Disorder><Dysfunction><Failure><Fumarate Reductase><Functional disorder><Funding><Genetic><Goals><HPGF><HSF Gene><Health><Hepatocyte Stimulatory Factor Gene><Hepatocyte-Stimulating Factor><Homeostasis><Human><Hybridoma Growth Factor><Hybridoma Growth Factor Gene><IFN-beta 2><IFNB2><IFNB2 Gene><IL-17><IL-17 Gene><IL-17A><IL-17A Gene><IL-23><IL-6><IL-6 Gene><IL17><IL17 Protein><IL17 gene><IL17A><IL17A Gene><IL21><IL6><IL6 Protein><IL6 gene><Immune system><Impairment><Infectious Diseases><Infectious Disorder><Inflammaging><Inflammation><Inflammatory><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) Gene><Interleukin 17 Precursor><Interleukin 17 Precursor Gene><Interleukin 6 (Interferon, Beta 2) Gene><Interleukin-17><Interleukin-6><Interleukin-6 Gene><Intermediary Metabolism><Intracellular Communication and Signaling><L-Serine><Leanness><Length of Life><Life><Link><Longevity><MGI-2><Macrophage-Derived TNF><Malignant Neoplasms><Malignant Tumor><Maps><Metabolic><Metabolic Processes><Metabolism><Mitochondria><Modern Man><Monocyte-Derived TNF><Myeloid Differentiation-Inducing Protein><NF-E2 protein><NF-E2 transcription factor><NFE2 protein><Organelles><Outcome><Oxidation-Reduction><PBMC><Pathology><Pathway interactions><Peripheral Blood Mononuclear Cell><Phosphorylation><Physiological Homeostasis><Physiopathology><Plasmacytoma Growth Factor><Position><Positioning Attribute><Primary Senile Degenerative Dementia><Production><Protein Phosphorylation><Proteins><Publishing><QOL><Quality of life><Redox><Regulation><Regulatory Protein><SDZ RAD><STAT3><STAT3 gene><Serine><Signal Transduction><Signal Transduction Systems><Signaling><Source><Structure><Subcellular Process><Succinate Dehydrogenase><Succinic Dehydrogenase><Succinic Oxidase><T cell regulation><T-Cells><T-Lymphocyte><T-cell inflamed><T4 Cells><T4 Lymphocytes><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Testing><Thinness><Translational Research><Translational Science><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Work><adult youth><adulthood><age associated><age associated alterations><age associated changes><age associated decline><age associated disease><age associated disorder><age associated effects><age associated impairment><age associated pathologies><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent decline><age dependent disease><age dependent disorder><age dependent impairment><age dependent pathologies><age effect><age induced alterations><age induced changes><age induced pathologies><age linked><age related><age related alterations><age related changes><age related decline><age related effects><age related human disease><age specific><age specific alterations><age specific changes><age-related disease><age-related disorder><age-related impairment><age-related inflammation><ages><aging associated><aging associated alterations><aging associated changes><aging associated inflammation><aging associated pathologies><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging dependent pathologies><aging effect><aging induced alterations><aging induced changes><aging induced pathologies><aging pathologies><aging related><aging related alterations><aging related changes><aging related pathologies><aging specific alterations><aging specific changes><alterations with age><autophagy><biological signal transduction><cancer progression><cardiovascular disorder><cell growth regulation><changes with age><clinical translation><clinically translatable><constitutive expression><constitutive gene expression><cytokine><decline with age><developmental><diabetes><druggable target><enhance healthspan><everolimus><extend healthspan><extending healthy lifespan><fumarate hydrogenase><functional outcomes><gain of function><genetic regulatory protein><healthspan><healthspan extension><healthy life span><impact of age><improve healthspan><improved><increase healthspan><inflamm-ageing><inflamm-aging><inflammation associated with aging><influence of age><inhibitor><interferon beta 2><interleukin-21><interleukin-23><malignancy><mitochondrial><neoplasm progression><neoplasm/cancer><neoplastic progression><nuclear factor-erythroid 2><older adult><older adulthood><oxidation reduction reaction><pathophysiology><pathway><pharmacologic><prevent><preventing><primary degenerative dementia><pro-aging><progeronic><prolong healthspan><promote aging><promote healthspan><protein expression><regulatory gene product><senile dementia of the Alzheimer type><thymus derived lymphocyte><trait><translation research><translational investigation><tumor progression><tumorigenic><young adult><young adult age><young adulthood>
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Jenjira Jennie Yahirun

BOWLING GREEN STATE UNIVERSITY, BOWLING GREEN, OH

Exploratory lead · 20/100
Solid budget
Active award
$430,386
FY 2022

Project Title

Older Adult Dementia Risk and Offspring Education in the United States

Grant Number:

1R15AG074050-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2022

End Date:

5/31/2026

Project Abstract

In the U.S., the number of older adults living with Alzheimer’s Disease and Related Dementias (ADRD) is increasing. Significant loss of memory and reasoning skills can destroy quality of life for the individual as well as their family members. However, education is a protective resource: Older adult...

Research Terms

<0-11 years old><AD dementia><AD related dementia><ADRD><Accounting><Adult Children><Adult Daughters><Adult Offspring><Adult Sons><Aging><Alzheimer><Alzheimer Type Dementia><Alzheimer disease><Alzheimer related dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimers Dementia><Alzheimers disease><Amentia><American><Area><Award><Child><Child Youth><Children (0-21)><Chronic><Cognitive><Collaborations><Communication><Communication Research><Data><Data Analyses><Data Analysis><Data Analytics><Dementia><Disadvantaged><Education><Education Level><Educational Achievement><Educational Background><Educational Status><Educational aspects><Elderly><Emotional Depression><Environment><Faculty><Family><Family member><Fecundability><Fecundity><Fertility><Gender><Generations><Goals><Health><Health Benefit><Health and Retirement Study><Health behavior><Health behavior outcomes><Improve Access><Individual><Lead><Learning><Length of Life><Life Cycle><Life Cycle Stages><Light><Link><Longevity><Measures><Memory Loss><Mentors><Mentorship><Mission><Outcome><Outcomes Research><Parents><Pathway interactions><Pb element><Personal Satisfaction><Persons><Photoradiation><Primary Senile Degenerative Dementia><Process><Public Health><QOL><Quality of life><Race><Racial Group><Racial Stocks><Research><Research Priority><Research Resources><Resources><Risk><Risk Factors><Role><Schools><Scientist><Shapes><Social Class><Strategic Planning><Students><Subgroup><Training><United States><Universities><Woman><Work><Writing><advanced age><alzheimer risk><black male><black men><brain health><cognitive function><data interpretation><data management><dementia of the Alzheimer type><dementia risk><depression symptom><depressive><depressive symptoms><disparity in health><education resources><educational level><educational resources><elders><experience><geriatric><graduate student><health data><health disparity><health related behavior><heavy metal Pb><heavy metal lead><higher education><improved><intergenerational><late life><later life><life course><life span><lifespan><memory decline><next generation><offspring><older adult><older person><pathway><population health><prevent><preventing><primary degenerative dementia><public health relevance><risk factor for dementia><risk for dementia><senile dementia of the Alzheimer type><senior citizen><skills><social><social role><training achievement><training level><training status><trend><undergrad><undergraduate><undergraduate student><well-being><wellbeing><youngster>
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Elana S Ehrlich

TOWSON UNIVERSITY, TOWSON, MD

Exploratory lead · 20/100
Solid budget
Active award
$430,285
FY 2025

Project Title

RTA-Induced Ubiquitination in KSHV: A CURE-Based Approach to Identify Novel Targets and Small Molecule Inhibitors

Grant Number:

1R15AI186824-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2028

Project Abstract

Abstract: This R15 AREA grant application proposes a Course-based Undergraduate Research Experience (CURE) to investigate RTA-induced ubiquitination in the context of Kaposi's Sarcoma Herpesvirus (KSHV) latency and lytic replication to identify cellular targets for intervention while providing authe...

Research Terms

<20S Catalytic Proteasome><20S Core Proteasome><20S Proteasome><20S Proteosome><ABC Transporter, MHC, 2><ABCB3><AIDS Virus><AIDS/HIV><APF-1><APT2><ATP-Binding Cassette, Sub-Family B, Member 3><ATP-Dependent Proteolysis Factor 1><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Africa><Age><Antigen Peptide Transporter 2><Antisense Agent><Antisense Oligonucleotides><Apoptosis><Apoptosis Pathway><Applications Grants><Assay><Bioassay><Biological Assay><Biology><Biomedical Research><Burkitt Herpesvirus><Burkitt Lymphoma Virus><Cancers><Cell Body><Cell Communication and Signaling><Cell Cycle Control><Cell Cycle Regulation><Cell Function><Cell Line><Cell Physiology><Cell Process><Cell Signaling><CellLine><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular biology><Clinical><Data><Data Set><Development><Diagnosis><Disease><Disorder><Doxycycline><E3 Ligase><E3 Ubiquitin Ligase><EB virus><EBV><Educational process of instructing><Epstein Barr Virus><Gene Expression><Goals><Graduate Education><Grant Proposals><HHV-4><HHV-8><HHV4><HHV8><HIV><HIV Infections><HIV/AIDS><HMG-20><HTLV-III Infections><HTLV-III-LAV Infections><Herpes infection><Herpesviridae Infections><Herpesviridae disease><Herpesvirus Infections><High Mobility Protein 20><Human Herpesvirus 4><Human Herpesvirus 8><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Infections><IPTG><Immune response><Immunomodulation><Incidence><Individual><Infectious Mononucleosis Virus><Inflammatory><Intervention><Intracellular Communication and Signaling><Isopropyl Thiogalactoside><KSHV><Kaposi Sarcoma><Kaposi Sarcoma-Associated Herpes Virus><Kaposi Sarcoma-Associated Herpesvirus><Kaposi sarcoma associated virus><Kaposi sarcoma herpes virus><Kaposi's Sarcoma><Kaposi's sarcoma (KS)-associated herpesvirus><Knowledge><LAV-HTLV-III><Life Cycle><Life Cycle Stages><Ligase><Ligase Gene><Link><Lymphadenopathy-Associated Virus><Lytic><Macropain><Macroxyproteinase><Malignant Neoplasms><Malignant Oral Cavity Neoplasm><Malignant Oral Cavity Tumor><Malignant Oral Neoplasm><Malignant Tumor><Mediating><Modification><Mouth Cancer><Multicatalytic Proteinase><Multicentric Angiofollicular Lymphoid Hyperplasia><Multicentric Castleman's Disease><Multiple Hemorrhagic Sarcoma><Names><Oral Cancer><Outcome><PSF2><Patients><Peptide Supply Factor 2><Peptide Transporter PSF2><Peptides><Persons><Play><Process><Production><Programmed Cell Death><Prosome><Proteasome><Proteasome Endopeptidase Complex><Proteins><Proteome><Proteomics><Proteosome><RING11><Research><Resistance><Role><Science><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Site-Directed Mutagenesis><Site-Specific Mutagenesis><Staining method><Stains><Strains Cell Lines><Students><Subcellular Process><Syndrome><Synthetases><System><TAP2><TAP2 gene><Targeted DNA Modification><Targeted Modification><Teaching><Therapeutic><Transcriptional Control><Transcriptional Regulation><Transporter, ATP-Binding Cassette, Major Histocompatibility Complex, 2><Ubiquitilation><Ubiquitin><Ubiquitin Ligase Component Gene><Ubiquitin Ligase Gene><Ubiquitin Like Proteins><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Ubiquitination><Ubiquitinoylation><Underrepresented Groups><Underrepresented Populations><Vaccines><Vibramycin><Viral><Viral Genes><Viral Latency><Virus><Virus Latency><Virus-HHV8><Virus-HIV><Work><ages><alpha-6-Deoxyoxytetracycline><antiretroviral therapy><antiretroviral treatment><antisense oligo><biological signal transduction><career><career preparation><career readiness><cell biology><cellular targeting><comparative><cultured cell line><cytokine><design><designing><developmental><examination questions><experience><experiment><experimental research><experimental study><experiments><host response><immune modulation><immune reconstitution><immune regulation><immune system response><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><job readiness><kaposi's sarcoma herpesvirus><kaposi's sarcoma-associated human herpesvirus><knock-down><knockdown><latent infection><life course><lytic replication><lytic viral replication><lytic virus replication><malignancy><malignant mouth neoplasm><malignant mouth tumor><multicastleman's diseases><multicatalytic endopeptidase complex><mutant><name><named><naming><neoplasm/cancer><novel><novel virus><oral cavity cancer><primary effusion lymphoma><resistant><shRNA><short hairpin RNA><small hairpin RNA><small molecular inhibitor><small molecule><small molecule inhibitor><social role><student engagement><student motivation><student participation><therapeutic target><tool><ubiquination><ubiquitin conjugation><ubiquitin ligase><ubiquitin-protein ligase><under representation of groups><under represented groups><under represented people><under represented populations><undergrad><undergraduate><undergraduate research experience><undergraduate research opportunities><undergraduate research programs><undergraduate student><underrepresentation of groups><underrepresented people><virus host interaction><work readiness><workforce readiness><workplace readiness>
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Jennifer Celene Veilleux

UNIVERSITY OF ARKANSAS AT FAYETTEVILLE, FAYETTEVILLE, AR

Exploratory lead · 20/100
Solid budget
Active award
$429,725
FY 2024

Project Title

Targeting components of distress tolerance

Grant Number:

1R15MH136626-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2024

End Date:

4/30/2027

Project Abstract

PROJECT SUMMARY To decrease the worldwide burden of mental illness, it is essential to understand how precise mechanisms underlying treatments influence transdiagnostic symptoms of psychopathology. The goal of this R15 AREA award is to specifically target distress intolerance, a transdiagnostic vuln...

Research Terms

<Academic Research Enhancement Awards><Active Follow-up><Award><Behavior><Behavior Control><Behavioral Manipulation><Cognitive><Curiosities><Diagnostic><Dialectical behavior therapy><Distress><Ecological momentary assessment><Elements><Emotional><Emotional Depression><Emotions><Experimental Therapies><Feeling><Foundations><Funding Mechanisms><Future><Goals><Grant><Intervention><Intervention Strategies><Investigational Therapies><Investigational Treatments><Knowledge><Label><Life><Link><Maps><Maritally Unattached><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Methods><Mission><Motivation><NIH><NIMH><National Institute of Mental Health><National Institutes of Health><Negative Valence><Outcome><Participant><Personal Satisfaction><Persons><Precision care><Prediction of Response to Therapy><Prevention><Process><Protocol><Protocols documentation><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Psychopathology><Psychotherapy><Public Health><R15 Mechanism><R15 Program><RDoC><Randomized><Reporting><Research><Research Domain Criteria><Research Training><Risk Factors><Role><Self Efficacy><Series><Single Person><Strategic Planning><Symptoms><System><Testing><Therapeutic><Thinking><Time><Training><Treatment outcome><United States National Institutes of Health><Unmarried person><abnormal psychology><active followup><alleviate symptom><ameliorating symptom><anxiety symptoms><anxious symptom><behavioral control><daily functioning><decrease symptom><depression symptom><depressive><depressive symptoms><distraction><distress tolerance><emotion regulation><emotional experience><emotional regulation><experience><experimental therapeutic agents><experimental therapeutics><feelings><fewer symptoms><follow up><follow-up><followed up><followup><graduate student><improve symptom><improved><individualized care><individualized patient care><innovate><innovation><innovative><intervention effect><interventional strategy><mental illness><negative affect><negative affectivity><personalized care><personalized patient care><predict therapeutic response><predict therapy response><prevent><preventing><psychiatric illness><psychoeducation><psychologic><psychological><psychological disorder><randomisation><randomization><randomly assigned><reduce symptoms><relieves symptoms><skills><social><social role><symptom alleviation><symptom improvement><symptom reduction><symptom relief><symptomatic improvement><theories><therapy prediction><thoughts><treatment effect><treatment prediction><treatment response prediction><undergrad><undergraduate><undergraduate student><well-being><wellbeing><willingness>
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Vishwanath Venketaraman

WESTERN UNIVERSITY OF HEALTH SCIENCES, POMONA, CA

Exploratory lead · 20/100
Solid budget
Active award
$429,000
FY 2024

Project Title

Glutathione depletion in the CNS and its effects on Mtb infection

Grant Number:

2R15HL143545-02

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2019

End Date:

3/31/2027

Project Abstract

Project Summary: Tuberculous Meningitis (TBM) is the most severe form of extrapulmonary tuberculosis (TB) and is associated with significant morbidity and mortality in humans worldwide. Individuals with TBM show a marked deficiency in the levels of glutathione (GSH), the principal non-protein thiol ...

Research Terms

<AIDS/HIV><Address><Adopted><Anti Mycobacterial Agents><Antibiotic Therapy><Antibiotic Treatment><Antimycobacterial Agents><Antitubercular Agents><Antitubercular Drugs><Applications Grants><Arachnoid Membrane Inflammation><Arachnoiditis><Area><Autoregulation><Award><Bacillus><Bacteriology><Benemycin><Biochemical><Blood monocyte><CNS Nervous System><Cause of Death><Cell Body><Cells><Cellular Immune Function><Central Nervous System><Central Nervous System Tuberculosis><Cessation of life><Childhood><Clinical><Co-Stimulator><Costimulator><Cytotoxic cell><Death><Defense Mechanisms><Development><Diagnosis><Drug Therapy><Drug usage><Drugs><Early Diagnosis><Edodekin Alfa><Epidermal Thymocyte Activating Factor><Equilibrium><Female><Foundations><Functional impairment><Generalized Growth><Glutathione><Goals><Grant Proposals><Growth><HIV Infections><HIV/AIDS><HTLV-III Infections><HTLV-III-LAV Infections><Hematogenous><Homeostasis><Human><Human T-Lymphotropic Virus Type III Infections><IL-12><IL-2><IL12><IL2 Protein><IMiD><Immune><Immune mediated therapy><Immune modulatory therapeutic><Immune response><Immunes><Immunochemical Immunologic><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunologic><Immunological><Immunological response><Immunologically><Immunologically Directed Therapy><Immunologics><Immunosuppressed Host><Immunotherapeutic agent><Immunotherapy><Incidence><Individual><Interleukin 2><Interleukin 2 Precursor><Interleukin II><Interleukin-12><Interleukin-2><Interleukine 2><Interleukine 2 Precursor><Interleukine II><Intracranial Tuberculoma><Isonicotinic Acid Hydrazide><K lymphocyte><Low income><Lung><Lung Respiratory System><Lung TB><Lung Tuberculosis><Lymphocyte Mitogenic Factor><M tb><M tuberculosis><M tuberculosis infection><M. tb><M. tb infection><M. tuberculosis><M. tuberculosis infection><M.tb infection><M.tuberculosis infection><MTB infection><Macrophage><Marrow monocyte><Medical emergency><Medication><Meningeal TB><Meningeal Tuberculosis><Mercaptans><Mercapto Compounds><Mice><Mice Mammals><Mitogenic Factor><Modern Man><Morbidity><Morbidity - disease rate><Murine><Mus><Mycobacterial Infection><Mycobacterium Infections><Mycobacterium tuberculosis><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><Mφ><NK Cells><NKSF><Natural Killer Cell Stimulatory Factor><Natural Killer Cells><Neuraxis><Neurologic><Neurological><Outcome><Oxidation-Reduction><Pathogenesis><Pathologic><Persons><Pharmaceutical Preparations><Pharmacotherapy><Physiologic><Physiological><Physiological Homeostasis><Predisposition><Pulmonary TB><Pulmonary Tuberculosis><Redox><Refractory><Regimen><Reporting><Research><Rifadin><Rifampicin><Rifampin><Rimactane><Risk><Specific qualifier value><Specified><Spinal><Spleen><Spleen Reticuloendothelial System><Sulfhydryl Compounds><Susceptibility><T cell growth factor><T-Cell Growth Factor><T-Cell Stimulating Factor><T-Cells><T-Lymphocyte><TB drugs><TB infection><TB meningitis><Testing><Therapeutic Agents><Thiols><Thymocyte Stimulating Factor><Tissue Growth><Tuberculosis><Tuberculosis Meningitis><Tuberculostatic Agents><Tuberculous Meningitis><anti-TB><anti-TB drugs><anti-tuberculosis><anti-tuberculosis drugs><antiTB><antimycobacterial><bacterial disease treatment><bacterial infectious disease treatment><balance><balance function><combat><cytokine><developmental><disseminated TB><disseminated tuberculosis><drug treatment><drug use><drug/agent><early detection><effective therapy><effective treatment><extensive drug resistance><extensively drug resistant><extreme drug resistance><gamma-L-Glu-L-Cys-Gly><gamma-L-Glutamyl-L-Cysteinylglycine><host response><immune drugs><immune function><immune modulating agents><immune modulating drug><immune modulating therapeutics><immune modulatory agents><immune modulatory drugs><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapeutics><immune-based therapies><immune-based treatments><immuno therapy><immunologic therapeutics><immunomodulating agents><immunomodulating drugs><immunomodulator agent><immunomodulator drug><immunomodulator medication><immunomodulator prodrug><immunomodulator therapeutic><immunomodulatory agents><immunomodulatory drugs><immunomodulatory therapeutics><immunoresponse><immunosuppressed patient><immunotherapeutics><immunotherapy agent><improved><in vitro activity><in vivo><infection due to Mycobacterium tuberculosis><isoniazid><male><monocyte><mortality><mtb><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><ontogeny><oxidation reduction reaction><pediatric><prevent><preventing><protective effect><psychological defense mechanism><pulmonary><resistance strain><resistant strain><response><restoration><sulfhydryl group><thymus derived lymphocyte><tuberculosis drugs><tuberculosis infection><tuberculous spondyloarthropathy>
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Paul R Reynolds

BRIGHAM YOUNG UNIVERSITY, PROVO, UT

Exploratory lead · 20/100
Solid budget
Active award
$428,639
FY 2025

Project Title

Dissecting inflammatory outcomes following eCigarette exposure

Grant Number:

2R15HL152257-02

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2020

End Date:

12/31/2027

Project Abstract

Project Abstract Elucidating molecular pathways that coordinate inflammatory responses and histopathology is of paramount importance in the study of lung disease and possible treatments. Our current R15 led to novel discoveries related to roles for RAGE in coordinating cellular responses to tobacco ...

Research Terms

<1,2,3-Propanetriol><1,2,3-Trihydroxypropane><2-Propenal><AGE receptor><Acceleration><Acraldehyde><Acrolein><Acrylaldehyde><Acrylic Aldehyde><Acute><Adolescent><Adolescent Youth><Advertising><Aerosols><Affect><Alleles><Allelomorphs><Allyl Aldehyde><Animal Model><Animal Models and Related Studies><Animals><Belief><Biological><Biology><Bladder><Bladder Urinary System><Body Tissues><Cell Communication and Signaling><Cell Death><Cell Signaling><Cell Survival><Cell Viability><Chronic><Chronic Periodontitis><Collection><DNA Molecular Biology><Data><Disease Progression><Dysfunction><Education><Educational aspects><Electronic cigarette><Environment><Esteroproteases><Ethers><Ethylene Aldehyde><Evaluation><Event><Experimental Designs><Exposure to><Flavorant><Flavoring><Flavoring Agents><Formaldehyde><Formic Aldehyde><Functional disorder><Glycerin><Glycerol><Glycosaminoglycans><Goals><Grant><Health><Heating><Histologic><Histologically><Histopathology><Human><Individual><Inflammation><Inflammatory><Inflammatory Response><Intracellular Communication and Signaling><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Ligands><Link><Lung><Lung Diseases><Lung Inflammation><Lung Respiratory System><Measures><Mediating><Medical><Methodology><Methyl Aldehyde><Mice><Mice Mammals><Mind><Modeling><Modern Man><Modernization><Molecular><Molecular Biology><Mucopolysaccharides><Murine><Mus><NIH><National Institutes of Health><Nicotine><Null Mouse><Organism-Level Process><Organismal Process><Outcome><Oxomethane><Passive Smoke Exposure><Pathogenesis><Pathway interactions><Peptidases><Peptide Hydrolases><Periodontitis><Phosphorylation><Physiologic Processes><Physiological Processes><Physiology><Physiopathology><Pneumonitis><Position><Positioning Attribute><Prevention><Propanediols><Propylene Glycols><Protease Gene><Proteases><Protein Phosphorylation><Proteinases><Proteolytic Enzymes><Public Opinion><Publications><Pulmonary Diseases><Pulmonary Disorder><Pulmonary Inflammation><RAGE receptor><Receptor Protein><Research><Research Priority><Research Resources><Resources><Role><Science><Scientific Publication><Signal Transduction><Signal Transduction Systems><Signaling><Smoking><Students><Testing><Tissues><Tobacco smoke><Transgenic Mice><United States><United States National Institutes of Health><acryaldehyde><activation product><advanced glycosylation end product receptor><amphoterin receptor><attenuation><biologic><biological signal transduction><carcinogenicity><combustible cigarette><conventional cigarette><cytokine><differential expression><differentially expressed><disease of the lung><disorder of the lung><e-cig><e-cig aerosols><e-cig use><e-cig vapor><e-cigarette><e-cigarette aerosols><e-cigarette use><e-cigarette vapor><e-vape><ecig><ecig aerosols><ecig use><ecig vapor><ecigarette><ecigarette aerosols><ecigarette use><ecigarette vapor><electronic cigarette aerosol><electronic cigarette use><electronic cigarette vapor><electronic vape><environmental tobacco smoke exposure><expectation><experience><exposure to ETS><exposure to SHS><exposure to environmental tobacco smoke><exposure to secondhand smoke><exposure to tobacco smoke><health assessment><human disease><human model><inhibitor><innovate><innovation><innovative><juvenile><juvenile human><lung disorder><lung health><model of animal><model of human><necrocytosis><novel><oral mucositis><oromucositis><overexpress><overexpression><pathophysiology><pathway><pre-clinical development><preclinical development><primarily undergraduate institution><pulmonary><pulmonary health><receptor><receptor for AGE><receptor for advanced glycation end product><receptor for advanced glycation endproducts><receptor of AGE><response><sRAGE><second hand smoke exposure><secondhand smoke exposure><secondhand tobacco smoke exposure><skills><social role><soluble RAGE><tobacco products><tobacco smoke exposure><traditional cigarette><transcriptional differences><trend><undergrad><undergraduate><undergraduate student><urinary bladder><vaping>
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Katie Garrison

UNIVERSITY OF ALABAMA IN TUSCALOOSA, TUSCALOOSA, AL

Exploratory lead · 20/100
Solid budget
Active award
$427,868
FY 2023

Project Title

Examining the Relationship between Executive Functioning and Cognitive Reappraisal Ability in Daily Life

Grant Number:

1R15MH133153-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2023

End Date:

5/14/2027

Project Abstract

PROJECT SUMMARY The goal of this R15 Research Enhancement Award is to elucidate the role and impact of executive functioning in relation to the use of cognitive reappraisal as an emotion regulation strategy. Cognitive reappraisal is a key process in cognitive therapies and cognitive behavioral thera...

Research Terms

<21+ years old><Adult><Adult Human><Affective><Affective Disorders><Anxiety><Area><Award><Behavioral><Characteristics><Clinical><Cognition Therapy><Cognitive><Cognitive Psychotherapy><Cognitive Therapy><Communities><Data><Development><Educational process of instructing><Emotional><Emotional Depression><Emotions><Environment><Event><Exhibits><Film><Foundations><Future><Goals><Habits><Immediate Memory><Impairment><Individual><Individual Differences><Institution><Instruction><Intervention><Intervention Strategies><Laboratories><Life><Link><Maintenance><Measures><Mental Depression><Mental disorders><Mental health disorders><Methodology><Mood Disorders><Noise><Participant><Patient Self-Report><Patients><Persons><Physiology><Prefrontal Cortex><Process><Psychiatric Disease><Psychiatric Disorder><Research><Research Infrastructure><Role><Sampling><Self-Report><Short-Term Memory><Shortterm Memory><Stimulus><Stress><Stressful Event><Structure><Survey Instrument><Surveys><Teaching><Thinking><Time><Training><Treatment outcome><Work><adulthood><anxiety treatment><behavior study><behavioral study><cognitive ability><cognitive behavior intervention><cognitive behavior modification><cognitive behavior therapy><cognitive behavioral intervention><cognitive behavioral modification><cognitive behavioral therapy><cognitive behavioral treatment><cognitive process><cognitive reappraisal><cognitive regulation><data collection methodology><depression><depression symptom><depressive><depressive symptoms><developmental><diaries><emotion regulation><emotional regulation><emotional stimulus><executive control><executive function><experience><individual heterogeneity><individual variability><individual variation><innovate><innovation><innovative><interventional strategy><mental illness><negative affect><negative affectivity><neural imaging><neuro-imaging><neuroimaging><neurological imaging><new approaches><novel><novel approaches><novel strategies><novel strategy><positive mood><psychiatric illness><psychological disorder><response><satisfaction><selective attention><self esteem><skills><social><social role><stressful experience><stressful life event><stressful life experience><stressor><student training><success><thoughts><treatment of anxiety disorders><working memory>
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PAUL L DURHAM

MISSOURI STATE UNIVERSITY, SPRINGFIELD, MO

Exploratory lead · 20/100
Solid budget
Active award
$427,500
FY 2024

Project Title

Grape Seed Extract Modulation of Peripheral and Central Nervous System Neuron-Glia Interactions

Grant Number:

1R15AT012501-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2027

Project Abstract

Principal Investigator: Durham, Paul Louis Summary Our long-term goal is to better understand the cellular and molecular changes in neuron-glia communication mediated by a polyphenol-enriched grape seed extract (GSE) to reduce the burden of chronic pain. Based on findings from our prior NIH grant, w...

Research Terms

<3'5'-cyclic ester of AMP><3,5 cyclic AMP synthetase><Academic Research Enhancement Awards><Adenosine Cyclic 3',5'-Monophosphate><Adenosine Cyclic Monophosphate><Adenosine Cyclic Monophosphate-Dependent Protein Kinases><Adenosine, cyclic 3',5'-(hydrogen phosphate)><Adenyl Cyclase><Adenylate Cyclase><Adenylyl Cyclase><Agonist><Astrocytes><Astrocytus><Astroglia><Astroprotein><Baclofen><Binding><Biological Markers><CGRP Receptors><CNS Nervous System><CSAID-Binding Protein 1><CSAID-Binding Protein 2><CSBP2><Calcitonin Gene-Related Peptide><Calcitonin-Gene Related Peptide Receptor><Cannabinoids><Cell Communication and Signaling><Cell Signaling><Central Nervous System><Chlorophenyl GABA><Chronic><Communication><Coupled><Couples><Coupling><Cyclic AMP><Cyclic AMP-Dependent Protein Kinases><Cytokine-Suppressive Antiinflammatory Drug-Binding Protein 1><Cytokine-Suppressive Antiinflammatory Drug-Binding protein 2><Data><Development><Dietary Supplementation><Endocannabinoids><Endogenous Cannabinoids><Enzyme Gene><Enzymes><Foundations><Future><GFA-Protein><GFAP><Gasser's Ganglion><Gasserian Ganglion><Glia><Glial Cells><Glial Fibrillary Acid Protein><Glial Fibrillary Acidic Protein><Glial Intermediate Filament Protein><Glutamates><Goals><Grant><Hortega cell><INOS><Image><Immunoblotting><In Vitro><Inducible Nitric Oxide Synthase><Inflammatory><Institution><Intracellular Communication and Signaling><Ion Channel><Ionic Channels><Ions><Kolliker's reticulum><L-Glutamate><MAP kinase><MAPK14><MAPK14 Mitogen-Activated Protein Kinase><MAPK14 gene><Macrophage Nitric Oxide Synthase><Maintenance><Mediating><Medicine><Medulla Spinalis><Membrane Channels><Messenger RNA><Microglia><Migraine><Migraine Headache><Mitogen-Activated Protein Kinase 14><Mitogen-Activated Protein Kinases><Molecular><Molecular Interaction><Molecular Target><Muscle satellite cell><Mxi2><NCCAM><NCCIH><NIH><NOS2><NOS2A><NOS2A gene><NOS2A, Inducible, Hepatocyte><National Center for Complementary and Integrative Health><National Center for Complementary and Integrative Medicine><National Institutes of Health><Nerve Cells><Nerve Unit><Nervous System><Neural Cell><Neuraxis><Neurilemma Cell><Neurilemmal Cell><Neurocyte><Neurogenic Inflammation><Neuroglia><Neuroglial Cells><Neurologic Body System><Neurologic Organ System><Neurons><Nitric Oxide Synthase 2A><Nociception><Non-neuronal cell><Nonneuronal cell><Nucleus of the Spinal Tract of the Trigeminal Nerve><Nutraceutical><Opiates><Opioid><Orofacial Pain><PCP-GABA><PKA><Pain><Painful><Pathology><Pathway interactions><Patients><Peripheral><Peripheral Nervous System><Pharmaceutical Agent><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Physiologic><Physiological><Pre-Clinical Model><Preclinical Models><Principal Investigator><Procedures><Protein Kinase A><Proteins><Publishing><R15 Mechanism><R15 Program><RAMP1><RNA Seq><RNA sequencing><RNAseq><Receptor Inhibition><Receptor Protein><Reporting><Role><SAPK2A><Schwann Cells><Semilunar Ganglion><Signal Transduction><Signal Transduction Systems><Signaling><Spinal Cord><Spinal Trigeminal Nucleus><Stress-Activated Protein Kinase 2A><Structure of trigeminal ganglion><Structure of trigeminal nerve spinal tract nucleus><Symptoms><TMJ Diseases><TMJ Disorders><TMJD><Techniques><Temporomandibular Disorders><Temporomandibular Joint Diseases><Temporomandibular Joint Disorders><Temporomandibular Joint and Muscle Disorder><Testing><Therapeutic><Trigeminal Ganglias><Trigeminal Ganglion><Trigeminal Pain><Trigeminal System><United States National Institutes of Health><Western Blotting><Western Immunoblotting><adenosine 3'5' monophosphate><antagonism><antagonist><astrocytic glia><bio-markers><biologic marker><biological signal transduction><biomarker><cAMP><cAMP-Dependent Protein Kinases><central sensitization><chronic pain><chronic pain control><chronic pain intervention><chronic pain management><chronic pain therapy><chronic pain treatment><developmental><diet supplementation><dietary><endogenous opiate><endogenous opioids><gitter cell><glial activation><glial cell activation><glutamatergic><grape seed extract><grapeseed extract><imaging><immunocytochemistry><in vivo><inhibitor><insight><lower sensory nucleus of trigeminal nerve><mRNA><mesoglia><microglial cell><microgliocyte><nerve cement><neuronal><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><nociceptive><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><oral facial pain><p38><p38 MAP Kinase><p38 MAPK Gene><p38 Mitogen Activated Protein Kinase><p38 Protein Kinase><p38 SAPK><p38-Alpha><p38Alpha><pain signal><pathway><perivascular glial cell><pharmaceutical><polyphenol><programs><protein blotting><protein expression><receptor><response><satellite cell><social role><therapeutically effective><transcriptome sequencing><transcriptomic sequencing><treat chronic pain><trigeminal><undergrad><undergraduate><undergraduate student>
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Sarah Black

KENT STATE UNIVERSITY, KENT, OH

Exploratory lead · 20/100
Solid budget
Active award
$426,610
FY 2023

Project Title

Parent-child synchrony in depressed and non-depressed dyads: A multi-modal investigation

Grant Number:

1R15MH132055-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2023

End Date:

7/31/2026

Project Abstract

Project Summary/Abstract Synchrony, or coordination of parent and child behaviors, emotions, and physiology during dyadic interactions, is critical to the development of adaptive emotion regulation skills in youth. Parental depression, however, has been shown to influence patterns of behavioral and ...

Research Terms

<0-11 years old><10 year old><10 years of age><6-11 years old><Academic Research Enhancement Awards><Address><Aeroseb-HC><Age><Autonomic nervous system><Behavior><Behavioral><Biological><Cetacort><Child><Child Behavior><Child Development><Child Rearing><Child Youth><Children (0-21)><Cort-Dome><Cortef><Cortenema><Cortisol><Cortispray><Cortril><Data><Depressed mood><Dermacort><Development><Diagnosis><Eldecort><Electrodermal Response><Emotions><Environment><Exposure to><Family><Fathers><Frustration><Funding><Galvanic Skin Response><Goals><Health Priorities><History><Hydrocortisone><Hydrocortone><Hytone><Individual><Infant and Child Development><Informal Social Control><Investigation><Investigators><Literature><Measures><Mental Depression><Methods><NIMH><National Institute of Mental Health><Nutracort><Outcome><Parasympathetic Nervous System><Parenting><Parenting behavior><Parents><Pattern><Physiologic><Physiological><Physiology><Play><Problem behavior><Proctocort><Psychogalvanic Reflex><Psychopathology><R15 Mechanism><R15 Program><RDoC><Recording of previous events><Research><Research Domain Criteria><Research Methodology><Research Methods><Research Personnel><Research Resources><Researchers><Resources><Risk><Risk Factors><Role><Self Regulation><Sinus Arrhythmia><Skin Electric Conductance><Stress><Students><Sympathetic Nervous System><Symptoms><System><Transmission><Universities><Work><Youth><Youth 10-21><abnormal psychology><adolescent depression><adolescents with depression><age 10 years><ages><behavioral problem><biologic><biological systems><biopsychosocial><child depression><childhood depression><childhood onset depression><childrearing><depressed><depressed adolescents><depression><depression in adolescence><developmental><dyadic interaction><emotion dysregulation><emotion regulation><emotional dysregulation><emotional functioning><emotional regulation><histories><indexing><intergenerational><kids><methods to study multiple-level influences><middle childhood><multi-level analysis><multi-level model><multi-modality><multilevel analysis><multilevel model><multilevel modeling><multimodality><neglect><parent><pediatric depression><programs><research and methods><respiratory><response><sadness><sex><skills><skin conductance><social role><ten year old><ten years of age><transmission process><undergrad><undergraduate><undergraduate student><youngster><youth depression>
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LAUREN Alene O'DONNELL

DUQUESNE UNIVERSITY, PITTSBURGH, PA

Exploratory lead · 20/100
Solid budget
Active award
$426,057
FY 2024

Project Title

Rescuing myelination in viral infections of the juvenile brain

Grant Number:

1R15NS141047-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/20/2024

End Date:

8/31/2027

Project Abstract

PROJECT SUMMARY Viruses are well-established causes of central nervous system (CNS) disease in the most vulnerable populations, particularly in the young and immunocompromised. During CNS infection, the immune response can inadvertently cause neuropathology, resulting in neuronal death and demyelina...

Research Terms

<0-11 years old><21+ years old><Academic Research Enhancement Awards><Acute><Address><Adolescent><Adolescent Youth><Adult><Adult Human><Affect><Age><Animal Model><Animal Models and Related Studies><Automobile Driving><B blood cells><B cell><B cells><B-Cell Subsets><B-Cells><B-Lymphocyte Subsets><B-Lymphocytes><B-cell><Binding><Brain><Brain Inflammation><Brain Nervous System><Bystander Effect><CD 46 antigen><CD46><CD46 Antigen><CNS Diseases><CNS Nervous System><CNS disorder><CNS infection><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Count><Cell Differentiation><Cell Differentiation process><Cell Growth in Number><Cell Interaction><Cell Locomotion><Cell Maturation><Cell Migration><Cell Movement><Cell Multiplication><Cell Number><Cell Proliferation><Cell Signaling><Cell-to-Cell Interaction><Cells><Cellular Migration><Cellular Motility><Cellular Proliferation><Central Nervous System><Central Nervous System Diseases><Central Nervous System Disorders><Central Nervous System Infections><Central Nervous System Infectious Disease><Central Nervous System Infectious Disorder><Central Nervous System Viral Diseases><Central Nervous System Viral Infections><Child><Child Youth><Childhood><Children (0-21)><Complex><Cues><Data><Degenerative Neurologic Disorders><Demyelinating Diseases><Demyelinating Disorders><Demyelinations><Development><Disseminated Sclerosis><Doctor of Pharmacy><Educational process of instructing><Encephalitis><Encephalon><Genetic><Goals><Immune><Immune Globulins><Immune response><Immunes><Immunization><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunoglobulins><Immunological response><Immunosuppressed Host><In Vitro><Infection><Infiltration><Inflammation><Intracellular Communication and Signaling><Investigators><Knowledge><Left><Literature><MCP antigen><Measles virus><Mediating><Mentors><Mice><Mice Mammals><Mission><Modeling><Molecular><Molecular Interaction><Multiple Sclerosis><Murine><Mus><Myelin><Natural regeneration><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neuraxis><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Deficit><Neurologic Degenerative Conditions><Neurologic Disorders><Neurological Disorders><Neurons><Neurosciences><Oligodendrocytes><Oligodendrocytus><Oligodendroglia><Oligodendroglia Cell><Outcome><Output><Pathogenicity><Patients><Ph D student><Ph D. student><Ph. D. student><Ph.D student><Ph.D. student><PhD student><PhD. student><Pharm.D.><PharmD><Play><Position><Positioning Attribute><Proliferating><R15 Mechanism><R15 Program><Recovery><Regeneration><Research><Research Personnel><Researchers><Role><Series><Signal Transduction><Signal Transduction Systems><Signaling><Stress><Students><Survivors><Teaching><Testing><Therapeutic><Training><Viral><Viral CNS Infections><Viral Diseases><Virus><Virus Diseases><Vulnerable Populations><Work><adaptive immune response><adulthood><ages><antagonism><antagonist><anti-viral immunity><antiviral immunity><biological signal transduction><brain cell><brain repair><cell motility><cellular differentiation><critical developmental period><de-myelinating diseases><de-myelinating disorders><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><demyelinate><demyelinating conditions><demyelination diseases><demyelination disorders><develop therapy><developmental><doctoral student><driving><experience><experiment><experimental research><experimental study><experiments><host response><immune system response><immunoglobulin receptor><immunoresponse><immunosuppressed patient><in vivo><inflammatory environment><inflammatory milieu><insight><insular sclerosis><intervention development><juvenile><juvenile human><kids><membrane cofactor protein><model of animal><mouse model><murine model><myelination><nerve cell death><nerve cell loss><neural inflammation><neurodegenerative illness><neuroinflammation><neuroinflammatory><neurological disease><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal><neuronal cell death><neuronal cell loss><neuronal death><neuronal loss><neuropathologic><neuropathological><neuropathology><novel><oligodendrocyte precursor><oligodendrocyte progenitor><oligodendrocyte stem cell><paracrine><pediatric><pharmacologic><precursor cell><preservation><re-myelinate><re-myelination><regenerate><remyelinate><remyelination><repair><repaired><response><restoration><rougeole virus><rubeola virus><social role><student mentoring><student-led learning><therapy development><tool><treatment development><undergrad><undergraduate><undergraduate student><viral infection><viral-induced demyelination><virology><virus infection><virus-induced demyelination><virus-induced disease><vulnerable group><vulnerable individual><vulnerable people><youngster>
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MELANIE T WARZISKI TURK

DUQUESNE UNIVERSITY, PITTSBURGH, PA

Exploratory lead · 20/100
Solid budget
Active award
$426,032
FY 2023

Project Title

Multi-Stakeholder Determinants of Medicare Diabetes Prevention Program Implementation and Participation

Grant Number:

1R15HL163736-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2023

End Date:

6/30/2026

Project Abstract

PROJECT SUMMARY/ABSTRACT Nearly half of US adults age ≥ 65 (> 24 million) have prediabetes, which is often a precursor to type 2 diabetes mellitus (T2DM) and associated cardiovascular (CV) diseases and mortality. To address this public health burden, the Centers for Medicare and Medicaid Services en...

Research Terms

<21+ years old><65+ years old><Address><Adoption><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Affect><Aged 65 and Over><American><Application Context><Assess implementation><Awareness><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 public health crisis><COVID19 crisis><COVID19 epidemic><COVID19 global health crisis><COVID19 global pandemic><COVID19 health crisis><COVID19 pandemic><COVID19 public health crisis><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Centers for Medicare and Medicaid Services><Characteristics><Community Health Care><Community Healthcare><Complex><Consolidated Framework for Implementation Research><Consolidated Framework for Implementation Science><Consolidated Framework for Implementing Change><Credentialing><Data><Date of birth><Development><Diabetes Mellitus><Disease><Disorder><Elderly><Elements><Eligibility><Eligibility Determination><Enrollment><Ensure><Environment><Evidence based intervention><Exposure to><Future><Goals><Health Care Financing Administration><Health Care Providers><Health Insurance for Aged and Disabled, Title 18><Health Insurance for Disabled Title 18><Health Personnel><Healthcare Providers><Healthcare worker><Heart Vascular><Implementation assessment><Implementation readiness><Individual><Infrastructure><Interdisciplinary Research><Interdisciplinary Study><Intervention><Intervention Strategies><Interview><Investigation><Ketosis-Resistant Diabetes Mellitus><Life Style><Lifestyle><Link><Maturity-Onset Diabetes Mellitus><Medical Care Costs><Medicare><Methods><Multidisciplinary Collaboration><Multidisciplinary Research><NIDDM><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Nursing Students><On-Line Systems><Online Systems><Outcome><Participant><Persons><Pharmacy Students><Phone><Physicians><Prediabetes><Prediabetes syndrome><Prediabetic State><Prevention program><Process><Protocol Screening><Provider><Public Health><Pupil Nurses><Research><Risk><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-CoV2 epidemic><SARS-CoV2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SET Domain><Sampling><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Site><Slow-Onset Diabetes Mellitus><Social Security Number><Stable Diabetes Mellitus><Survey Instrument><Surveys><T2 DM><T2D><T2DM><Telephone><Title 18><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><United States Centers for Medicare and Medicaid Services><United States Health Care Financing Administration><Universities><adult onset diabetes><adulthood><advanced age><age 65 and greater><age 65 and older><aged 65 and greater><aged ≥65><barriers to implementation><behavior change><beneficiary><burden of disease><burden of illness><cardiovascular disorder><circulatory system><co-morbid><co-morbidity><community care><comorbidity><contextual factors><corona virus disease 2019 epidemic><corona virus disease 2019 pandemic><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><cost><developmental><diabetes><diabetes prevention program><disability burden><disease burden><disease prevention><disorder prevention><elders><enroll><evaluate implementation><evaluation of implementation><evidence base><experience><geriatric><health care organization><health care personnel><health care service organization><health care worker><health insurance for disabled><health provider><health workforce><healthcare organization><healthcare personnel><healthcare service organization><human old age (65+)><implementation barriers><implementation challenges><implementation evaluation><implementation facilitation><implementation intervention><implementation process><implementation research><implementation strategy><improved><interventional strategy><ketosis resistant diabetes><late life><later life><life style intervention><lifestyle intervention><maturity onset diabetes><medical costs><medical personnel><meeting><meetings><member><mortality><old age><older adult><older person><online computer><pre-diabetes><pre-diabetic><prediabetic><preservation><prevent><preventing><programs><recruit><senior citizen><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><strategies for implementation><success><theories><tool><treatment provider><type 2 DM><type II DM><type two diabetes><undergrad><undergraduate><undergraduate student><web based><years of life lost to disability><years of life lost to disease>
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Xiao NMN Zhang

MICHIGAN TECHNOLOGICAL UNIVERSITY, HOUGHTON, MI

Exploratory lead · 20/100
Solid budget
Active award
$425,790
FY 2023

Project Title

Bayesian modeling of multivariate mixed longitudinal responses with scale mixtures of multivariate normal distributions

Grant Number:

1R15GM151700-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2023

End Date:

7/31/2026

Project Abstract

Program Summary (Abstract) Health-related studies generally involve more than one longitudinal response composed of multiple types of data, such as binary, ordinal, nominal or continuous variables. Since these responses are collected from the same individual or unit, it is desirable to analyze them ...

Research Terms

<Academic Research Enhancement Awards><Algorithms><Bayesian Analysis><Bayesian Method><Bayesian Methodology><Bayesian Modeling><Bayesian Statistical Method><Bayesian adaptive designs><Bayesian adaptive models><Bayesian approaches><Bayesian belief network><Bayesian belief updating model><Bayesian classification method><Bayesian classification procedure><Bayesian computation><Bayesian framework><Bayesian hierarchical model><Bayesian inference><Bayesian network analysis><Bayesian network model><Bayesian nonparametric models><Bayesian posterior distribution><Bayesian spatial analysis><Bayesian spatial data model><Bayesian spatial image models><Bayesian spatial models><Bayesian statistical analysis><Bayesian statistical inference><Bayesian statistical models><Bayesian statistics><Bayesian tracking algorithms><Charge><Communities><Computing Methodologies><Data><Data Set><Development><Diagnostic><Dimensions><Education><Educational aspects><Environment><Exposure to><Gaussian Distribution><Health><Human><Individual><Likelihood Functions><Logistics><Markov Chains><Markov Process><Markov chain Monte Carlo algorithms><Markov chain Monte Carlo computational algorithm><Markov chain Monte Carlo method><Markov chain Monte Carlo methodology><Markov chain Monte Carlo procedure><Markov chain Monte Carlo sampling><Markov chain Monte Carlo simulation><Markov chain Monte Carlo technique><Methods><Michigan><Mission><Modeling><Modern Man><Modernization><NIH><National Institutes of Health><Normal Distribution><Normal Statistical Distribution><Parameter Estimation><Performance><Public Health><R15 Mechanism><R15 Program><Research><Research Infrastructure><Sampling><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Statistical Methods><Structure><Survey Instrument><Surveys><Technology><United States National Institutes of Health><Universities><Work><complex data><computational methodology><computational methods><computational tools><computer based method><computer methods><computerized tools><computing method><developmental><flexibility><flexible><high dimensionality><multiple data types><novel><programs><public health relevance><response><statistic methods><statistical analysis><tech development><technology development><theories><undergrad><undergraduate><undergraduate student><user friendly computer software><user friendly software>
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Anamaria Gabriella Zavala

BOISE STATE UNIVERSITY, BOISE, ID

Exploratory lead · 20/100
Solid budget
Active award
$424,500
FY 2024

Project Title

The Role of Mechanical Stress in Mitigating Side Effects of Chemotherapy

Grant Number:

1R15CA293993-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2024

End Date:

6/30/2027

Project Abstract

First line platinum-based chemotherapies kill cancer cells through formation of bulky DNA adducts, however, these adducts also form in healthy tissues leading to side effects that significantly impact patients’ quality of life. Post-therapy bone loss has been linked to chemotherapy-induced stem cell...

Research Terms

<Abscission><Apoptosis><Apoptosis Pathway><Biomedical Engineering><Biomedical Research><Body Tissues><Breast><CDDP><Cancer Patient><Cancer Survivor><Cancers><Carcinogen-DNA Adducts><Cell Aging><Cell Body><Cell Cycle Checkpoint><Cell Senescence><Cell Survival><Cell Viability><Cells><Cellular Aging><Cellular Matrix><Cellular Mechanotransduction><Cellular Senescence><Cerebral Palsy><Cervical><Chemotherapy Protocol><Chemotherapy Regimen><Chemotherapy-Oncologic Procedure><Chromatin><Cis-diammine-dichloroplatinum><Cis-diamminedichloridoplatinum><Cis-diamminedichloro Platinum (II)><Cis-dichloroammine Platinum (II)><Cis-platinous Diamine Dichloride><Cis-platinum II><Cis-platinum II Diamine Dichloride><Cisplatin><Cisplatina><Cisplatinum><Clinical><Combination Chemotherapy Regimen><Complex><Cysplatyna><Cytoskeletal System><Cytoskeleton><DDIT1><DNA><DNA Adducts><DNA Damage><DNA Damage Repair><DNA Damage-Inducible Gene GADD45><DNA Damage-Inducible Transcript 1><DNA Excision Repair Protein ERCC-1><DNA Injury><DNA Repair><Data><Deoxyribonucleic Acid><Dichlorodiammineplatinum><Disabling><Disabling condition><Disabling health condition><Doctor of Philosophy><Dose><Down-Regulation><Drugs><ERCC1><ERCC1 gene><Education><Educational aspects><Effectiveness><Elements><Excision><Excision Repair Cross-Complementation Group 1><Excision Repair Cross-Complementing 1><Excision Repair Cross-Complementing Rodent Repair Deficiency, Complementation Group 1><Exercise><Extirpation><Fatigue><Foundations><Frequencies><GADD45><GADD45A><GADD45A gene><Genetics-Mutagenesis><Growth Arrest-and DNA Damage-Inducible Gene GADD45, Alpha><Idaho><Individual><Intervention><Intervention Strategies><Investigators><Kinetics><Lack of Energy><Link><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Mechanical Signal Transduction><Mechanical Stress><Mechanics><Mechanosensory Transduction><Mediating><Medication><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Modality><Modeling><Molecular Target><Muscle Cell Contraction><Muscle Contraction><Muscular Contraction><Mutagenesis><Mutagenesis Molecular Biology><Neoplasm Metastasis><Non-pharmacologic Therapy><Nonpharmacologic Intervention><Nonpharmacologic Therapy><Nonpharmacologic approach><Nonpharmacologic treatment><Nucleotide Excision Repair><Nucleotide Excision Repair Inhibition><Oncologist><Otomy><Outcome><Ovarian><Pathway interactions><Patients><Peyrone's Chloride><Peyrone's Salt><Ph.D.><PhD><Pharmaceutical Preparations><Physical activity><Platinum><Platinum Black><Platinum Diamminodichloride><Population><Process><Progenitor Cells><Programmed Cell Death><Pt element><Publications><QOL><Quality of life><Quimioterapia><RAD10><Recovery><Regimen><Regulation><Removal><Repair Complex><Replicative Senescence><Research><Research Personnel><Researchers><Role><Scientific Publication><Secondary Neoplasm><Secondary Tumor><Stress><Students><Surgical Removal><Surgical incisions><Testing><Therapeutic><Therapeutic Intervention><Tissues><Toxic effect><Toxicities><Toxicity due to chemotherapy><Treatment Efficacy><UV induced><UV radiation-induced><Universities><Unscheduled DNA Synthesis><Uterus><Work><adduct><bio-engineered><bio-engineers><bioengineering><biological engineering><bone><bone cell><bone loss><bone quality><cancer cell><cancer chemotherapy><cancer metastasis><cell cycle check point><cell killing><chemotherapy><chemotherapy toxicity><cis dichlorodiammineplatinum><cis platinum compound><cis-Diaminedichloroplatinum><cis-Diamminedichloroplatinum><cis-Diamminedichloroplatinum(II)><cis-Dichlorodiammineplatinum(II)><cis-Platinum><cisplatin-DNA adduct><clinical relevance><clinically relevant><disabled><drug/agent><experience><improved><incision><indexing><intervention efficacy><intervention therapy><interventional strategy><intracellular skeleton><live cell image><live cell imaging><live cellular image><live cellular imaging><long-term sequelae><malignancy><mechanic><mechanical><mechanical force><mechanosensing><mechanotransduction><mortality><neoplasm/cancer><neuron toxicity><neuronal toxicity><neurotoxicity><non-drug therapy><non-drug treatment><nondrug therapy><nondrug treatment><novel><overexpress><overexpression><pathway><prevent><preventing><programs><protein complex><quality of life and care for cancer survivors><quality of life for cancer survivors><repair><repaired><resection><response><senescence><senescent><side effect><social role><stem cells><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic efficacy><therapy efficacy><tumor cell metastasis><ultraviolet induced><ultraviolet light induced><ultraviolet radiation-induced><undergrad><undergraduate><undergraduate student><vibration><wasting><womb>
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RODNEY P GUTTMANN

UNIVERSITY OF WEST FLORIDA, PENSACOLA, FL

Exploratory lead · 20/100
Solid budget
Active award
$421,500
FY 2024

Project Title

Identifying biomarkers for the early detection of Alzheimer's disease using phage display

Grant Number:

2R15AG066122-02

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2020

End Date:

7/31/2027

Project Abstract

Project Summary The long-term goal of this study is to develop a biomarker-based screening assay for the detection of AD-related biochemical changes that can be measured in biofluids such as blood or CSF. The main goal of this study is to identify phage-based probes to protein post-translational mod...

Research Terms

<AD dementia><AD detection><AD related dementia><ADRD><Academic Research Enhancement Awards><Accuracy of Diagnosis><Address><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease detection><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's and related dementias><Alzheimer's detection><Alzheimer's diagnosis><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease diagnosis><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimers Dementia><Amentia><Aminoacetic Acid><Antigenic Determinants><Assay><Bacteriophages><Basic Mechanisms of SUMOylation><Binding><Binding Determinants><Bioassay><Biochemical><Biological Assay><Biological Markers><Biomedical Research><Blood><Blood Reticuloendothelial System><Blood Tests><Cell Communication and Signaling><Cell Signaling><Cerebrospinal Fluid><Clinical Evaluation><Clinical Testing><Clinical Trials><Clinical assessments><Data><Dementia><Disease><Disease Progression><Disorder><ELISA><Early Diagnosis><Enzyme-Linked Immunosorbent Assay><Epitopes><Equipment><Florida><Funding><Future><Glycine><Goals><Grant><Hematologic Tests><Hematological Tests><Hematology Testing><Image><In Vitro><Institution><Intracellular Communication and Signaling><Libraries><Link><MT-bound tau><Measurable><Measures><Metabolic Glycosylation><Methods><Modification><Molecular Configuration><Molecular Conformation><Molecular Interaction><Molecular Stereochemistry><Monitor><Pathologic><Peptides><Phage Display><Phages><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Primary Senile Degenerative Dementia><Procedures><Process><Protein Modification><Proteins><Qualifying><R15 Mechanism><R15 Program><Research><SUMOylation><Science><Sensitivity and Specificity><Signal Transduction><Signal Transduction Systems><Signaling><Sumoylation Pathway><Testing><Therapeutic><Universities><Work><abnormally aggregated tau protein><accurate diagnosis><bacterial virus><bio-markers><biologic marker><biological signal transduction><biomarker><biomarker array><biomarker identification><biomarker panel><blood-based biomarker><blood-based marker><career><cerebral spinal fluid><clinical diagnosis><clinical test><cohort><conformation><conformational><conformational state><conformationally><conformations><detection assay><diagnostic accuracy><early biomarkers><early detection><early detection biomarkers><early detection markers><enzyme linked immunoassay><filamentous tau inclusion><glycosylation><identification of biomarkers><identification of new biomarkers><imaging><improved><innovate><innovation><innovative><interest><marker identification><marker panel><microtubule associated protein tau aggregation><microtubule associated protein tau deposit><microtubule bound tau><microtubule-bound tau><p-tau><p-τ><paired helical filament of tau><phospho-tau><phospho-τ><phosphorylated tau><post-translational modification of tau><posttranslational modification of tau><prevent><preventing><primary degenerative dementia><protein expression><research clinical testing><screening><screenings><self-aggregate tau><senile dementia of the Alzheimer type><specific biomarkers><spinal fluid><synthetic peptide><tau><tau PHF><tau Proteins><tau accumulation><tau aggregate><tau aggregation><tau factor><tau fibrillization><tau filament><tau neurofibrillary tangle><tau oligomer><tau paired helical filament><tau phosphorylation><tau polymerization><tau posttranslational modification><tau-1><tau-tau interaction><undergrad><undergraduate><undergraduate student><τ Proteins><τ aggregation><τ phosphorylation>
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Ryan McGrath

NORTH DAKOTA STATE UNIVERSITY, FARGO, ND

Exploratory lead · 20/100
Solid budget
Active award
$421,230
FY 2025

Project Title

Examining Additional Attributes of Muscle Function for Cognitive Impairment in Older Adults

Grant Number:

2R15AG072348-02

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2022

End Date:

7/31/2028

Project Abstract

Handgrip strength (HGS) is collected in clinical and research settings as a feasible and reliable strength capacity measurement that generalizes to muscle function. Although low HGS is a risk factor for Alzheimer’s disease and Alzheimer’s disease related-dementias (AD/ADRD), concerns still exist reg...

Research Terms

<AD dementia><AD related dementia><ADRD><Abate><Accelerometer><Achievement><Achievement Attainment><Address><Age><Aging><Alcohol Drinking><Alcohol consumption><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimers Dementia><Amentia><Behavioral><Bilateral><Characteristics><Clinical><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collection><Data><Dementia><Dependence><Deterioration><Development><Diagnostic><Dimensions><Disturbance in cognition><Electronics><Eligibility><Eligibility Determination><Environment><Equipment><EtOH drinking><EtOH use><Evaluation><Extremities><Fostering><Goals><Grips><Groups at risk><Guidelines><Hand><Health><Health Care Providers><Health Personnel><Human><Impaired cognition><Infrastructure><Institution><Intervention><Investigation><Length of Life><Limb structure><Limbs><Link><Logistic Regressions><Longevity><Measurement><Measures><Mediating><Methods><Modeling><Modern Man><Motor><Muscle><Muscle Tissue><Muscle function><Nature><Non-Trunk><North Dakota><Outcome><Pathway interactions><Patient Care><Patient Care Delivery><Patients><People at risk><Performance><Persons at risk><Population><Populations at Risk><Precision Health><Prevalence><Preventative strategy><Prevention strategy><Preventive strategy><Primary Senile Degenerative Dementia><Procedures><Protocol><Protocol Screening><Protocols documentation><Publications><Research><Risk Factors><Sampling><Science><Scientific Publication><Series><Sleep><Students><System><Testing><Training><United States><Universities><Work><accelerometry><activity monitor><activity tracker><age associated disease><age associated disorder><age associated impairment><age dependent disease><age dependent disorder><age dependent impairment><age related human disease><age-related disease><age-related disorder><age-related impairment><ages><alcohol ingestion><alcohol intake><alcohol product use><alcohol use><alcoholic beverage consumption><alcoholic drink intake><alzheimer risk><care for patients><care of patients><caring for patients><cognitive change><cognitive dysfunction><cognitive function><cognitive loss><college><collegiate><combat><dementia burden><dementia risk><developmental><disability><electronic><electronic device><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><experience><graduate student><grasp><hands><health care personnel><health care worker><health provider><health workforce><improved><machine learning based model><machine learning model><medical personnel><mortality><muscular><neural><novel><older adult><older adulthood><pathway><preservation><prevent><preventing><primary degenerative dementia><risk factor for dementia><risk for dementia><senile dementia of the Alzheimer type><socio-demographics><sociodemographics><supervised learning><supervised machine learning><treatment provider><treatment strategy><undergrad><undergraduate><undergraduate student>
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Erin D Strome

NORTHERN KENTUCKY UNIVERSITY, HIGHLAND HEIGHTS, KY

Exploratory lead · 20/100
Solid budget
Active award
$420,000
FY 2024

Project Title

Characterization of SAM gene mutation impacts on cellular processes and genome instability

Grant Number:

2R15GM132818-02

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2020

End Date:

4/30/2027

Project Abstract

Abstract In Saccharomyces cerevisiae, Sam1, and its paralog Sam2, play roles in the methyl cycle catalyzing the biosynthesis of AdoMet. Despite Sam1 and Sam2 having high levels of homology and findings that both proteins localize to the cytoplasm, differences in abundance and regulation of expressio...

Research Terms

<ATP-Methionine S-Adenosyltransferase><Abscission><Alkylation><Anabolism><Assay><Baker's Yeast><Binding><Bioassay><Biological Assay><Biomedical Research><Brewer's Yeast><Cancer Treatment><Cancers><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Chromosomal Stability><Chromosome Mapping><Chromosome Stabilities><Cytoplasm><D Cells><DNA Molecular Biology><DNA Recombination><Data><Delta Cell><Development><Disease><Disorder><EC 2.1.1><Educational process of instructing><Environment><Event><Excision><Extirpation><Folate><Folic Acid><Funding><Gene Alteration><Gene Conversion><Gene Copy Number><Gene Deletion><Gene Dosage><Gene Localization><Gene Mapping><Gene Mapping Genetics><Gene Mutation><GeneHomolog><Genes><Genetic><Genetic Alteration><Genetic Change><Genetic Recombination><Genetic defect><Genome><Genome Instability><Genome Stability><Genomic Instability><Genomic Stability><Goals><Grant><Homolog><Homologous Gene><Homologue><Human><Individual><Institution><Investigation><Kentucky><Ligase><Ligase Gene><Link><Linkage Mapping><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Methylation><Methyltransferase><Micro Array Data><Modeling><Modern Man><Modernization><Molecular><Molecular Biology><Molecular Interaction><Mutation><Nature><Nucleotide Synthesis><Nucleotides><Pathway interactions><Phenotype><Play><Point Mutation><Polyamine Compound><Polyamines><Process><Production><Promoter Regions><Promotor Regions><Proteins><Proteome><Proteomics><Pteroylglutamic Acid><Public Health><Purines/Pyrimidines/Nucleotides/Nucleic Acids Metabolism><RNA Seq><RNA sequencing><RNAseq><Recombination><Regulation><Removal><Research><Ribonucleotide Reductase><Role><S cerevisiae><S-Adenosylmethionine Synthetase><S. cerevisiae><Saccharomyces cerevisiae><Scientist><Somatostatin Cells><Somatostatin Secreting Cell><Subcellular Process><Surgical Removal><Synthetases><System><Teaching><Techniques><Testing><Total Human and Non-Human Gene Mapping><Training><Universities><Vitamin M><Yeasts><anti-cancer therapy><biosynthesis><cancer therapy><cancer type><cancer-directed therapy><defined contribution><developmental><differential expression><differentially expressed><gene deletion mutation><genetic mapping><genetic promoter element><genetic promoter sequence><genome mutation><improved><insight><interest><malignancy><methionine adenosyltransferase><methyl group><methylase><multidisciplinary><mutant><neoplasm/cancer><nucleotide metabolism><paralog><paralogous gene><pathway><programs><promoter sequence><protective effect><resection><scientific literacy><scientifically literate><social role><transcriptional differences><transcriptome sequencing><transcriptomic sequencing><transmethylase><treatment planning><undergrad><undergraduate><undergraduate student><vitamin Bc>
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Justin Ryan Yates

NORTHERN KENTUCKY UNIVERSITY, HIGHLAND HEIGHTS, KY

Exploratory lead · 20/100
Solid budget
Active award
$420,000
FY 2023

Project Title

Contribution of BLA-mPFC pathway to risky choice and compulsive cocaine seeking

Grant Number:

2R15DA047610-02A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2019

End Date:

6/30/2026

Project Abstract

Project Summary/Abstract This is a resubmission of a renewal application for an AREA R15 grant to continue research funded in DA047610 (“Contribution of NMDA NR2B subunit to risky choice and economic demand for cocaine” now titled “Contribution of BLA-mPFC pathway to risky choice and compulsive coca...

Research Terms

<3-D><3-Dimensional><3D><Address><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Animal Model><Animal Models and Related Studies><Behavior><Behavioral><Catheters><Characteristics><Circulatory Collapse><Cocaine><Common Rat Strains><Crystal Meth><Crystal methamphetamine><DREADDs><Decision Making><Deoxyephedrine><Desoxyephedrine><Disease><Disorder><Dose><Drug usage><Drugs><EGFP protein><Economics><Education><Educational aspects><Extinction><Female><Food><Funding><Genetic><Glutamates><Goals><Grant><Implant><Imprisonment><Individual><Infusion><Infusion procedures><Injections><Institution><Intervention><Intervention Strategies><Kentucky><L-Glutamate><Measures><Medial><Mediating><Medication><Methamphetamine><Methylamphetamine><Modeling><N Methyl D aspartic Acid><N methyl D aspartate><N-Methyl-D-Aspartate Receptors><N-Methyl-D-aspartate><N-Methylamphetamine><N-Methylaspartate><N-Methylaspartate Receptors><NIH><NMDA><NMDA Receptor-Ionophore Complex><NMDA Receptors><National Institutes of Health><Nerve Cells><Nerve Unit><Neural Cell><Neural Pathways><Neurobiology><Neurocyte><Neurons><Neurosciences Research><Overdose><Pathway interactions><Pharmaceutic Preparations><Pharmaceutical Preparations><Pharmacology><Prefrontal Cortex><Probability><Psychological reinforcement><Punishment><Rat><Rats Mammals><Rattus><Receptor Protein><Recovery><Reinforcement><Relapse><Research><Rewards><Risk><Risk Behaviors><Risky Behavior><Role><Shock><Substance Use Disorder><Testing><Training><United States National Institutes of Health><Universities><Viral Vector><Withdrawal><addiction><addictive disorder><amygdaloid nuclear complex><antagonism><antagonist><at risk behavior><behavior construct><behavioral construct><circulatory shock><cocaine seeking><cocaine self-administration><conditioned place preference><design><designer receptors exclusively activated by designer drugs><designing><drug use><drug/agent><economic><effective therapy><effective treatment><efficacious therapy><efficacious treatment><enhanced green fluorescent protein><experience><experiment><experimental research><experimental study><experiments><flexibility><flexible><foot><genetic approach><genetic strategy><glutamatergic><incarcerated><incarceration><infusions><interventional strategy><male><meeting><meetings><meth><model of animal><neural circuit><neural circuitry><neural mechanism><neurobiological><neurocircuitry><neuromechanism><neuronal><novel><pain sensitivity><pathway><place conditioning><psychostimulant use disorder><receptor><reinforcer><response><self-administer cocaine><shocks><social role><stimulant use disorder><substance misuse><substance use><substance use and disorder><substance using><synaptic circuit><synaptic circuitry><three dimensional><undergrad><undergraduate><undergraduate student><vector control>
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Christine Perdan Curran

NORTHERN KENTUCKY UNIVERSITY, HIGHLAND HEIGHTS, KY

Exploratory lead · 20/100
Solid budget
Active award
$420,000
FY 2023

Project Title

Genetic Susceptibility to Developmental Benzo[a]pyrene Neurotoxicity

Grant Number:

2R15ES030541-02A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/16/2019

End Date:

7/31/2026

Project Abstract

Project Summary. This is a renewal application of an initial award to explore genetic susceptibility to benzo[a]pyrene (BaP)-induced developmental neurotoxicity. BaP is a model polycyclic aromatic hydrocarbon found in traffic-related air pollution (TRAP), wildfire and cigarette smoke and grilled foo...

Research Terms

<12-20 years old><2,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors><3,4-Benzopyrene><3,4-Benzpyrene><5-HT><5-Hydroxytryptamine><5HT><AH Receptors><AHRR><Acids><Adolescence><Adverse effects><Agonist><Ammon Horn><Animals><Area><Aromatic Compound-Inducible Cytochrome P-450><Aromatic Polycyclic Hydrocarbons><Aryl Hydrocarbon Receptor><Award><Bacteria><Behavior><Benzo(a)pyrene><Bio-Informatics><Bioinformatics><Body Tissues><Brain><Brain Nervous System><Brain region><CP11><CP12><CY11><CYP 1A2><CYP1A1><CYP1A1 gene><CYP1A2><CYP1A2 gene><CYP1B1><CYP1B1 gene><Caffeine Demethylase><Cell Communication and Signaling><Cell Signaling><Chemicals><Cigarette><Circulation><Cognition><Cornu Ammonis><Cytochrome P-450 CYP1A2><Cytochrome P-450 LM4><Cytochrome P-450d><Cytochrome P450 1A2><Data><Development><Dioxin Receptors><Dioxin-Inducible P3-450><Dose><EDS-4-hydroxylase><Encephalon><Enteramine><Environment><Enzyme Gene><Enzymes><Excretory function><Exposure to><Family><Food><Funding><Future><GI microbiome><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Genes><Genetic><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic propensity><Genotype><Gestation><Goals><Hippocampus><Hippophaine><Human><Human Activities><Impairment><Individual><Indoles><Inherited Predisposition><Inherited Susceptibility><Institution><Intermediary Metabolism><Intracellular Communication and Signaling><Investigators><KO mice><Kentucky><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Kynurenine><L-Tryptophan><Lactation><Learning><Levotryptophan><Life><Link><Mediating><Memory><Metabolic><Metabolic Processes><Metabolism><Mice><Mice Mammals><Modeling><Modern Man><Motor><Murine><Mus><Nerve Transmitter Substances><Nervous System Diseases><Neurologic Disorders><Neurological Disorders><Neurotransmitters><Nuclear Translocator><Null Mouse><P(3)450><P1-450><P3-450><P450 4><P450 Form 4><P450 orm 4><P450-C><P450-P3><P450DX><P450D\X><Pathway interactions><Phenacetin O-Dealkylase><Play><Polyaromatic Hydrocarbon Receptors><Population><Predisposition><Pregnancy><Problem behavior><Receptor Activation><Research><Research Personnel><Researchers><Resistance><Risk><Risk Reduction><Role><Serotonin><Shotgun Sequencing><Signal Transduction><Signal Transduction Systems><Signaling><Smoke><Susceptibility><TCDD Receptors><Techniques><Testing><Tissues><Transcript Expression Analyses><Transcript Expression Analysis><Tryptophan><Universities><Wild Type Mouse><Wildfire><Work><adolescence (12-20)><adult neurogenesis><ahr ligand><analyze gene expression><aryl hydrocarbon receptor ligand><behavior test><behavioral problem><behavioral test><beta diversity><biological signal transduction><cigarette smoke><cytochrome P450 CYP1B1><cytochrome P4501B1><developmental><developmental neurotoxicity><digestive tract microbiome><disadvantaged student><early childhood><early life exposure><enteric microbiome><estradiol 17-sulfate 4-hydroxylase><estradiol-4-hydroxylase><estrogen 4-hydroxylase><excretion><gastrointestinal microbiome><gene expression analysis><gene expression assay><genetic etiology><genetic mechanism of disease><genetic vulnerability><genetically predisposed><gut microbes><gut microbial species><gut microbiome><gut to brain axis><gut-associated microbiome><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><high risk><hippocampal><interest><intestinal biome><intestinal microbiome><lactating><lactational><member><metabolism measurement><metabolomics><metabonomics><mouse model><murine model><nervous system disorder><neural inflammation><neuroinflammation><neuroinflammatory><neurological disease><neuron toxicity><neuronal toxicity><neuroprotection><neuroprotective><neurotoxic><neurotoxicity><novel><pathway><polyaromatic hydrocarbons><polynuclear aromatic hydrocarbon><prenatal><pup><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><resistant><risk-reducing><social role><student training><students who are disadvantaged><traffic-related air pollution><transcriptional profiling><unborn><undergrad><undergraduate><undergraduate student><wild fire><wildland fire><wildtype mouse>
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Barbara Lee-Faubert Kaplan

MISSISSIPPI STATE UNIVERSITY, MISSISSIPPI STATE, MS

Exploratory lead · 20/100
Solid budget
Active award
$419,864
FY 2022

Project Title

Investigation of AhR Ligands on FcGamma Receptor Signaling: Consequences of Antibody Suppression

Grant Number:

2R15ES027650-02

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2017

End Date:

7/31/2026

Project Abstract

ABSTRACT: It is well known that TCDD and other aryl hydrocarbon receptor (AhR) ligands suppress antibody production but there is little information about the consequences of decreased antibody production on signaling through Fcg receptors (FcgR). FcgRs are expressed on several cell types and upon be...

Research Terms

<1H-indole-3-methanol><2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin><2,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors><3-hydroxymethylindole><7S Gamma Globulin><9-azafluorene><AH Receptors><Ab response><Ab-dependent cellular cytotoxicity><Acids><Agglutination><Agonist><Antibodies><Antibody Activation><Antibody Formation><Antibody Production><Antibody Suppression><Area><Aryl Hydrocarbon Receptor><Attenuated><Autoantigens><Autoimmune Diseases><Autologous Antigens><B blood cells><B cell><B cell growth factor><B cells><B-Cell Differentiation Factor-1><B-Cell Growth Factor-1><B-Cell Growth Factor-I><B-Cell Proliferating Factor><B-Cell Stimulating Factor><B-Cell Stimulating Factor-1><B-Cell Stimulation Factor-1><B-Cell Stimulatory Factor-1><B-Cells><B-Lymphocytes><B-cell><B220><BCDF-1><BCGF><BCGF-1><BCSF 1><BSF-1><BSF1><Binding><Binetrakin><CD19><CD19 gene><CD45><Carbazoles><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Complement Activation><Cytotoxic cell><Dioxin Receptors><Disseminated Sclerosis><EAE><Endocytosis><Esters><Experimental Allergic Encephalitis><Experimental Allergic Encephalomyelitis><Experimental Autoimmune Encephalitis><Experimental Autoimmune Encephalomyelitis><GP180><Goals><Human><I3C><I3C cpd><IL-4><IL4 Protein><IgG><IgG1><IgG3><Immune response><Immunoglobulin G><Immunological response><Immunotoxicology><In Vitro><Indole-3-Carbinol><Interleukin-4><Interleukin-4 Precursor><Intracellular Communication and Signaling><Investigation><K lymphocyte><LY5><Lymphocyte Stimulatory Factor 1><MCGF-2><MOG glycoprotein><Mast Cell Growth Factor-2><Mediating><Mice><Mice Mammals><Modeling><Modern Man><Molecular Interaction><Multiple Sclerosis><Murine><Mus><Myelin><NK Cells><Natural Killer Cells><Nuclear Translocator><Oligodendrocytes><Oligodendrocytus><Oligodendroglia><Oligodendroglia Cell><PBMC><PTPRC><PTPRC gene><Pathogenicity><Peripheral Blood Mononuclear Cell><Peritoneal Macrophages><Phagocytosis><Play><Polyaromatic Hydrocarbon Receptors><Production><RNA Seq><RNA sequencing><RNAseq><Receptor Protein><Receptor Signaling><Role><Self-Antigens><Signal Transduction><Signal Transduction Systems><Signaling><Splenocyte><T-Cell Growth Factor 2><T200><TCDD><TCDD Receptors><Testing><Tetrachlorodibenzodioxin><Work><ahr ligand><antibody biosynthesis><antibody dependent cell mediated cytotoxicity><antibody dependent cytotoxicity><antibody mediated cellular cytotoxicity><antibody-dependent cell cytotoxicity><antibody-dependent cellular cytotoxicity><antibody-mediated cytotoxicity><aryl hydrocarbon receptor ligand><autoimmune condition><autoimmune disorder><autoimmune encephalomyelitis><biological signal transduction><cell killing><cell type><complement pathway regulation><cytokine><dibenzopyrrole><dietary><diphenylenimine><effective therapy><effective treatment><extracellular><host response><immune system response><immunoglobulin biosynthesis><immunoresponse><immunotoxicity><indole-3-methanol><insular sclerosis><myelin oligodendrocyte glycoprotein><oligodendrocyte-myelin glycoprotein><pathogen><receptor><receptor-mediated signaling><recruit><sex><social role><toxic reaction in immunology><transcriptome sequencing>
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Javier Ochoa-Reparaz

BOISE STATE UNIVERSITY, BOISE, ID

Exploratory lead · 20/100
Solid budget
Active award
$418,493
FY 2025

Project Title

Therapeutic Mechanisms of Farnesol in Modulating Gut Dysbiosis and Neuroinflammation in Multiple Sclerosis

Grant Number:

1R15AI191202-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/20/2025

End Date:

5/31/2028

Project Abstract

ABSTRACT Multiple sclerosis (MS) is a prevalent autoimmune disease affecting nearly one million individuals in the United States. MS is characterized by neuroinflammatory demyelination within the central nervous system (CNS), facilitated by immune cell infiltration through a disrupted blood-brain ba...

Research Terms

<3,7,11-trimethyl-2,6,10-dodecatrien-1-ol><Active Oxygen><Affect><Autoimmune Diseases><Autoimmune biomarker><Autoimmune disease biomarker><Autoimmunity biomarker><Autoimmunity marker><BBB disruption><Bacteria><Biological><Biomedical Research><Blood Serum><Blood Vessels><Body Tissues><Body Weight><Brain><Brain Ischemia><Brain Nervous System><CNS Nervous System><CaCo2><Caco-2 Cells><Cardiac><Cell Body><Cell Line><CellLine><Cells><Central Nervous System><Chronic Disease><Chronic Illness><Clinical><Collection><Data><Demyelinations><Disease><Disease Progression><Disorder><Disseminated Sclerosis><EAE><Electric Resistance><Electrical Resistance><Encephalon><Endothelium><Environment><Epithelial Cells><Epithelium><Euthanasia><Experimental Allergic Encephalitis><Experimental Allergic Encephalomyelitis><Experimental Autoimmune Encephalitis><Experimental Autoimmune Encephalomyelitis><Exposure to><FITC-dextran><Farnesol><Feces><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><GI microbiota><Gastrointestinal microbiota><Goals><Grant><Gut Epithelial Permeability><Gut Hyperpermeability><Gut permeability><Human><Immune infiltrates><Immunologic Subtyping><Immunophenotyping><In Vitro><Individual><Inflammation><Inflammation Mediators><Institution><Interdisciplinary Research><Interdisciplinary Study><Intestinal Epithelial Permeability><Intestinal Hyperpermeability><Intestinal permeability><Ischemia><Ischemic Encephalopathy><Ischemic Heart><Ischemic Heart Disease><Ischemic myocardium><Knowledge><Lactobacillus><Lamina Propria><Linear Regressions><Measurement><Mercy Killing><Methods><Mice><Mice Mammals><Microbial Biofilms><Modeling><Modern Man><Molecular><Multidisciplinary Collaboration><Multidisciplinary Research><Multiple Sclerosis><Murine><Mus><Myocardial Ischemia><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neuraxis><Neurocyte><Neuron Degeneration><Neurons><Occluding Junctions><Outcome><Outcome Measure><Oxidative Stress><Oxygen Radicals><Pathway interactions><Permeability><Persons><Prevalence><Pro-Oxidants><Property><Proteins><Reactive Oxygen Species><Reporting><Research><Research Activity><Ribosomal RNA><Role><Serum><Severities><Severity of illness><Strains Cell Lines><Students><Therapeutic><Therapeutic Effect><Tight Junctions><Time><Tissues><Translating><United States><Universities><Yeasts><Zonula Occludens><autoimmune condition><autoimmune disorder><autoimmune encephalomyelitis><autoimmunity disease><beta diversity><biofilm><biologic><biomarker against autoimmune disease><biomarker in autoimmune disease><blood-brain barrier disruption><bloodbrain barrier disruption><bowel inflammation><cardiac ischemia><channel blockers><chronic disorder><clinical applicability><clinical application><coronary ischemia><cultured cell line><cytokine><demyelinate><disease severity><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiota><fecal sample><flow cytophotometry><fluorescein isothiocyanate dextran><fluoresceinthiocarbamoyl dextrans><fungal microbiome><fungal microbiota><gastrointestinal microbial flora><graduate student><gut community><gut dysbiosis><gut flora><gut inflammation><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiota><gut microbiotic><gut microflora><gut to brain axis><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><heart ischemia><immune cell infiltrate><improved><in vivo><inflamed bowel><inflamed gut><inflamed intestine><inflammation marker><inflammatory marker><inflammatory mediator><insight><insular sclerosis><intestinal barrier><intestinal epithelium><intestinal flora><intestinal inflammation><intestinal microbiota><intestinal microflora><intestinal mucosal barrier><intestinal tract microflora><isoprenoid><measurable outcome><meeting><meetings><mesenteric lymph node><mesentery lymph node><mevalonate><microbial consortia><microbial flora><microbial imbalance><microbiota><microflora><monolayer><multispecies consortia><mycobiome><mycobiota><myocardial ischemia/hypoxia><myocardium ischemia><neural degeneration><neural inflammation><neurodegeneration><neurodegenerative><neuroinflammation><neuroinflammatory><neurological degeneration><neuronal><neuronal degeneration><novel><outcome measurement><pathway><pre-clinical><preclinical><prevent><preventing><protein expression><quorum sensing><rRNA><sex><social role><stool><stool sample><stool specimen><systemic inflammation><systemic inflammatory response><transcriptomics><treatment group><undergrad><undergraduate><undergraduate student><vascular><voltage>
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ROMAN S VORONOV

NEW JERSEY INSTITUTE OF TECHNOLOGY, NEWARK, NJ

Exploratory lead · 20/100
Solid budget
Active award
$416,312
FY 2022

Project Title

An Automated Microfluidics Technology for Minimally Disruptive Analysis of Cells and Fluids within Living 3D Cultures

Grant Number:

1R15GM145610-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2022

End Date:

6/30/2026

Project Abstract

SUMMARY Cell experiments are ubiquitous to the studies of biology, tissue engineering and drug testing. However, 3D cultures are notoriously difficult to analyze nondestructively. Instead, they are typically evaluated using sacrificial means: such as histology sectioning, or by crushing the sample ...

Research Terms

<3-D><3-D print><3-D printer><3-Dimensional><3D><3D Print><3D cell culture><3D culture><3D printer><3D printing><Abscission><Academic Research Enhancement Awards><Address><Adoption><Agonist><Architecture><Assay><Bioassay><Biologic Assays><Biological><Biological Assay><Biology><Biopsy><Blood Vessels><Body Tissues><Cell Body><Cell Culture Techniques><Cell Death><Cell-Extracellular Matrix><Cells><Chemicals><Collagen><Collecting Cell><Coloring Agents><Complex><Computers><Controlled Environment><Cosmetics><Custom><Data><Deposit><Deposition><Development><Diffusion><Drug Delivery><Drug Delivery Systems><Drugs><Dyes><ECM><Engineering / Architecture><Ensure><Excision><Exposure to><Extirpation><Extracellular Matrix><Feasibility Studies><Future><Goals><Hand><Histology><In Situ><Individual><Industry><Injections><Left><Liquid substance><Literature><Location><Medication><Microfluidics><Microscopic><Microscopy><Monitor><Nutrient><Organ Size><Outcome><Pattern><Pharmaceutic Preparations><Pharmaceutical Preparations><Physiologic><Physiological><Plant Embryos><Plant Zygotes><Plumbing><Poison><Production><R15 Mechanism><R15 Program><Reader><Recipe><Regenerative Medicine><Removal><Research><Sampling><Seeds><Specific qualifier value><Specified><Speed><Stream><Surgical Removal><System><Techniques><Technology><Thick><Thickness><Time><Tissue Engineering><Tissues><Toxic Chemical><Toxic Substance><Toxicology><Translating><Work><application in practice><artificial environment><bioengineered tissue><bioink><biologic><bone><cell behavior><cell culture><cell cultures><cell type><cellular behavior><combinatorial><cosmetic product><cost><cross-link><crosslink><design><designing><developmental><drug detection><drug testing><drug/agent><engineered tissue><experience><experiment><experimental research><experimental study><fluid><industry involvement><invention><liquid><microfluidic technology><microorganism><microorganism culture><multidisciplinary><necrocytosis><new technology><novel><novel technologies><operation><optic imaging><optical imaging><osteochondral><osteochondral tissue><practical application><prevent><preventing><prototype><resection><response><scaffold><scaffolding><scale up><seed><spatiotemporal><success><three dimensional><three dimensional cell culture><three dimensional printing><toxic compound><undergrad><undergraduate><undergraduate student><vascular><wasting><µfluidic><µfluidic technology>
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ERIKA Ann MONTANARO

UNIVERSITY OF NORTH CAROLINA CHARLOTTE, CHARLOTTE, NC

Exploratory lead · 20/100
Solid budget
Active award
$415,769
FY 2024

Project Title

Development and Validation of Remaining Measures to Assess the Bystander Intervention for Problematic Alcohol Use Model (BIPAUM)

Grant Number:

1R15AA031833-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2024

End Date:

8/31/2027

Project Abstract

Problematic alcohol use (PAU) is a common, yet serious, health issue among college students that can lead to negative outcomes such as assault, alcohol use disorders and even death. Although PAU often occurs in group settings, bystanders frequently choose to do nothing when witnessing their peers en...

Research Terms

<Alcohol abuse><Alcohol dependence><Approaches to prevention><Behavior><Cessation of life><Code><Coding System><Data><Death><Development><Environment><EtOH abuse><Evaluation><Event><Factor Analyses><Factor Analysis><Feedback><Focus Groups><Frequencies><Funding><Gender><Health><Interpersonal Violence><Intervention><Intervention Strategies><Interview><Measurement><Measures><Mentors><Modeling><NIAAA><National Institute on Alcohol Abuse and Alcoholism><Nature><North Carolina><Outcome><Outcome Assessment><Population><Prevention approach><Primary Prevention><Property><Psychometrics><Research><Sampling><Students><Survey Instrument><Surveys><Testing><Universities><Validation><Work><alcohol addiction><alcohol co-abuse><alcohol dependency><alcohol dependent><alcohol problem><alcohol use disorder><analyzing longitudinal><assault><assaulted sexually><binge alcohol consumption><binge drinking><college><college student><collegiate><data cleaning><data cleansing><data dissemination><data management><design><designing><develop therapy><developmental><drinking><effective intervention><episodic drinking><ethanol abuse><ethanol use disorder><ethnic minority><hazardous alcohol use><high risk group><high risk individual><high risk people><high risk population><intervention development><intervention program><interventional strategy><longitudinal analysis><minority student><novel><peer><prevent><preventing><problem alcohol use><problem drinking><problematic alcohol consumption><problematic alcohol use><racial minority><recruit><response><sexual assault><sexual attack><sexual minority><social><student athlete><therapy development><treatment development><undergrad><undergraduate><undergraduate student><university student><validations>
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Annelise Mennicke

UNIVERSITY OF NORTH CAROLINA CHARLOTTE, CHARLOTTE, NC

Exploratory lead · 20/100
Solid budget
Active award
$415,769
FY 2024

Project Title

Development and Validation of Remaining Measures to Assess the Bystander Intervention for Problematic Alcohol Use Model (BIPAUM)

Grant Number:

1R15AA031833-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2024

End Date:

8/31/2027

Project Abstract

Problematic alcohol use (PAU) is a common, yet serious, health issue among college students that can lead to negative outcomes such as assault, alcohol use disorders and even death. Although PAU often occurs in group settings, bystanders frequently choose to do nothing when witnessing their peers en...

Research Terms

<Alcohol abuse><Alcohol dependence><Approaches to prevention><Behavior><Cessation of life><Code><Coding System><Data><Death><Development><Environment><EtOH abuse><Evaluation><Event><Factor Analyses><Factor Analysis><Feedback><Focus Groups><Frequencies><Funding><Gender><Health><Interpersonal Violence><Intervention><Intervention Strategies><Interview><Measurement><Measures><Mentors><Modeling><NIAAA><National Institute on Alcohol Abuse and Alcoholism><Nature><North Carolina><Outcome><Outcome Assessment><Population><Prevention approach><Primary Prevention><Property><Psychometrics><Research><Sampling><Students><Survey Instrument><Surveys><Testing><Universities><Validation><Work><alcohol addiction><alcohol co-abuse><alcohol dependency><alcohol dependent><alcohol problem><alcohol use disorder><analyzing longitudinal><assault><assaulted sexually><binge alcohol consumption><binge drinking><college><college student><collegiate><data cleaning><data cleansing><data dissemination><data management><design><designing><develop therapy><developmental><drinking><effective intervention><episodic drinking><ethanol abuse><ethanol use disorder><ethnic minority><hazardous alcohol use><high risk group><high risk individual><high risk people><high risk population><intervention development><intervention program><interventional strategy><longitudinal analysis><minority student><novel><peer><prevent><preventing><problem alcohol use><problem drinking><problematic alcohol consumption><problematic alcohol use><racial minority><recruit><response><sexual assault><sexual attack><sexual minority><social><student athlete><therapy development><treatment development><undergrad><undergraduate><undergraduate student><university student><validations>
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KEYKAVOUS PARANG

CHAPMAN UNIVERSITY, ORANGE, CA

Exploratory lead · 20/100
Solid budget
Active award
$415,500
FY 2025

Project Title

Peptide-Doxorubicin Conjugates for Mitigating Cardiotoxicity and Overcoming Drug Resistance in Cancer

Grant Number:

1R15CA301437-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/19/2025

End Date:

5/31/2028

Project Abstract

PROJECT SUMMARY Doxorubicin (DOX) is an FDA-approved anthracycline chemotherapy drug that is utilized for the treatment of a range of cancers, such as breast, lung, ovarian, gastric, and thyroid. However, the clinical application of DOX has demonstrated multidrug resistance and unfavorable pharmacok...

Research Terms

<14-Hydroxydaunomycin><4'-Epi-Adriamycin><4'-Epi-DXR><4'-Epi-Doxorubicin><4'-Epiadriamycin><4'-Epidoxorubicin><ABC20><ABCB1><ABCB1 gene><Active Oxygen><Address><Adriamycine><Affect><Anthracycline><Anti-Cancer Agents><Antineoplastic Agents><Antineoplastic Drugs><Antineoplastics><Apoptosis><Apoptosis Pathway><Arginine><Bioavailability><Biodistribution><Biological Availability><Body Tissues><Breast><Breast Cancer Cell><Bypass><Calcium><Cancer Drug><Cancer Treatment><Cancers><Cardiac><Cardiac Muscle Cells><Cardiac Myocytes><Cardiac Toxicity><Cardiocyte><Cardiotoxic><Cardiotoxicity><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cell Body><Cell Death><Cell Survival><Cell Viability><Cells><Clinical><Cyclic Peptides><Cyclicity><DHAQ><Data><Dihydroxyanthracenedione><Dose><Doxorubicin><Doxorubicina><Drug Delivery><Drug Delivery Systems><Drug Kinetics><Drug resistance><Drugs><Effectiveness><Ellence><Endosomes><Engineering><Epi DX><Epirubicin><Evaluation><Excretory function><Exhibits><Exposure to><Extravasation><FDA approved><Folate><Folic Acid><GP170><Generations><Heart><Heart Muscle Cells><Heart Vascular><Heart myocyte><Histologic><Histologically><Hybrids><Hydroxyl Daunorubicin><Hydroxyldaunorubicin><Immunodeficient Mouse><In Vitro><In vivo analysis><Institution><Investigation><L-Arginine><L-Tryptophan><Lead><Leakage><Levotryptophan><Lung><Lung Respiratory System><Lytotoxicity><MDR-1><MDR1><MDR1 Protein><Malignant Cell><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Measures><Medication><Membrane><Mice><Mice Mammals><Mission><Mitoxantrone><Mitozantrone><Monitor><Multi-Drug Resistance><Multidrug Resistance><Multidrug Resistance 1><Multidrug Resistance Gene-1><Multidrug Resistance Gene-1s><Multidrug Resistance Proteins><Multidrug Resistant Proteins><Multiple Drug Resistance><Multiple Drug Resistant><Murine><Mus><NCI Organization><NHLBI><NIH><National Cancer Institute><National Heart, Lung, and Blood Institute><National Institutes of Health><Neoplastic Disease Chemotherapeutic Agents><Nephrotoxic><Nuclear><Organ><Outcome><Ovarian><Oxygen Radicals><P-GP><P-Glycoprotein><P-Glycoprotein 1 Gene><PGY-1 Protein><PGY1><Pathway interactions><Pb element><Peptides><Periodicity><Pharmaceutical Preparations><Pharmacokinetics><Pharmorubicin PFS><Physiologic Availability><Pidorubicin><Pro-Oxidants><Programmed Cell Death><Proteins><Pteroylglutamic Acid><Reactive Oxygen Species><Receptosomes><Research><Resistance><Resistance to Multi-drug><Resistance to Multidrug><Resistance to Multiple Drug><Resistant to Multiple Drug><Resistant to multi-drug><Resistant to multidrug><Rhythmicity><Safety><Spillage><Stomach><Structure><System><TNBC><Testing><Therapeutic Agents><Thyroid><Thyroid Gland><Thyroid Head and Neck><Tissues><Toxic effect><Toxicities><Translational Research><Translational Science><Treatment Efficacy><Tryptophan><Tumor-Specific Treatment Agents><United States National Institutes of Health><Vitamin M><Xenograft Model><anti-cancer drug><anti-cancer therapy><anticancer activity><breast tumor cell><cancer cell><cancer therapy><cancer-directed therapy><cardiomyocyte><chemotherapeutic agent><chemotherapeutic compounds><chemotherapeutic drugs><chemotherapeutic medications><chemotherapy><circulatory system><clinical applicability><clinical application><combat><cytotoxic><cytotoxicity><design><designing><drug resistant><drug/agent><excretion><experiment><experimental research><experimental study><experiments><gastric><graduate student><heart cell><heavy metal Pb><heavy metal lead><improved><in vitro Model><in vivo><in vivo evaluation><in vivo testing><innovate><innovation><innovative><intervention efficacy><kidney toxicity><malignancy><membrane structure><molecular targeted therapeutics><molecular targeted therapies><molecular targeted treatment><multi-drug resistant><multidisciplinary><multidrug resistant><necrocytosis><neoplasm/cancer><nephrotoxicity><new approaches><novel approaches><novel strategies><novel strategy><overexpress><overexpression><pathway><peptide structure><pre-clinical development><preclinical development><refractory cancer><resistance mechanism><resistance to Drug><resistant><resistant cancer><resistant mechanism><resistant to Drug><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic efficacy><therapy efficacy><trafficking><translation research><translational investigation><translational opportunities><translational potential><triple-negative breast cancer><triple-negative invasive breast carcinoma><tumor><tumor growth><undergrad><undergraduate><undergraduate student><uptake><vitamin Bc><xenograft transplant model><xenotransplant model>
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SUN YANG

CHAPMAN UNIVERSITY, ORANGE, CA

Exploratory lead · 20/100
Solid budget
Active award
$415,500
FY 2025

Project Title

Peptide-Doxorubicin Conjugates for Mitigating Cardiotoxicity and Overcoming Drug Resistance in Cancer

Grant Number:

1R15CA301437-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/19/2025

End Date:

5/31/2028

Project Abstract

PROJECT SUMMARY Doxorubicin (DOX) is an FDA-approved anthracycline chemotherapy drug that is utilized for the treatment of a range of cancers, such as breast, lung, ovarian, gastric, and thyroid. However, the clinical application of DOX has demonstrated multidrug resistance and unfavorable pharmacok...

Research Terms

<14-Hydroxydaunomycin><4'-Epi-Adriamycin><4'-Epi-DXR><4'-Epi-Doxorubicin><4'-Epiadriamycin><4'-Epidoxorubicin><ABC20><ABCB1><ABCB1 gene><Active Oxygen><Address><Adriamycine><Affect><Anthracycline><Anti-Cancer Agents><Antineoplastic Agents><Antineoplastic Drugs><Antineoplastics><Apoptosis><Apoptosis Pathway><Arginine><Bioavailability><Biodistribution><Biological Availability><Body Tissues><Breast><Breast Cancer Cell><Bypass><Calcium><Cancer Drug><Cancer Treatment><Cancers><Cardiac><Cardiac Muscle Cells><Cardiac Myocytes><Cardiac Toxicity><Cardiocyte><Cardiotoxic><Cardiotoxicity><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cell Body><Cell Death><Cell Survival><Cell Viability><Cells><Clinical><Cyclic Peptides><Cyclicity><DHAQ><Data><Dihydroxyanthracenedione><Dose><Doxorubicin><Doxorubicina><Drug Delivery><Drug Delivery Systems><Drug Kinetics><Drug resistance><Drugs><Effectiveness><Ellence><Endosomes><Engineering><Epi DX><Epirubicin><Evaluation><Excretory function><Exhibits><Exposure to><Extravasation><FDA approved><Folate><Folic Acid><GP170><Generations><Heart><Heart Muscle Cells><Heart Vascular><Heart myocyte><Histologic><Histologically><Hybrids><Hydroxyl Daunorubicin><Hydroxyldaunorubicin><Immunodeficient Mouse><In Vitro><In vivo analysis><Institution><Investigation><L-Arginine><L-Tryptophan><Lead><Leakage><Levotryptophan><Lung><Lung Respiratory System><Lytotoxicity><MDR-1><MDR1><MDR1 Protein><Malignant Cell><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Measures><Medication><Membrane><Mice><Mice Mammals><Mission><Mitoxantrone><Mitozantrone><Monitor><Multi-Drug Resistance><Multidrug Resistance><Multidrug Resistance 1><Multidrug Resistance Gene-1><Multidrug Resistance Gene-1s><Multidrug Resistance Proteins><Multidrug Resistant Proteins><Multiple Drug Resistance><Multiple Drug Resistant><Murine><Mus><NCI Organization><NHLBI><NIH><National Cancer Institute><National Heart, Lung, and Blood Institute><National Institutes of Health><Neoplastic Disease Chemotherapeutic Agents><Nephrotoxic><Nuclear><Organ><Outcome><Ovarian><Oxygen Radicals><P-GP><P-Glycoprotein><P-Glycoprotein 1 Gene><PGY-1 Protein><PGY1><Pathway interactions><Pb element><Peptides><Periodicity><Pharmaceutical Preparations><Pharmacokinetics><Pharmorubicin PFS><Physiologic Availability><Pidorubicin><Pro-Oxidants><Programmed Cell Death><Proteins><Pteroylglutamic Acid><Reactive Oxygen Species><Receptosomes><Research><Resistance><Resistance to Multi-drug><Resistance to Multidrug><Resistance to Multiple Drug><Resistant to Multiple Drug><Resistant to multi-drug><Resistant to multidrug><Rhythmicity><Safety><Spillage><Stomach><Structure><System><TNBC><Testing><Therapeutic Agents><Thyroid><Thyroid Gland><Thyroid Head and Neck><Tissues><Toxic effect><Toxicities><Translational Research><Translational Science><Treatment Efficacy><Tryptophan><Tumor-Specific Treatment Agents><United States National Institutes of Health><Vitamin M><Xenograft Model><anti-cancer drug><anti-cancer therapy><anticancer activity><breast tumor cell><cancer cell><cancer therapy><cancer-directed therapy><cardiomyocyte><chemotherapeutic agent><chemotherapeutic compounds><chemotherapeutic drugs><chemotherapeutic medications><chemotherapy><circulatory system><clinical applicability><clinical application><combat><cytotoxic><cytotoxicity><design><designing><drug resistant><drug/agent><excretion><experiment><experimental research><experimental study><experiments><gastric><graduate student><heart cell><heavy metal Pb><heavy metal lead><improved><in vitro Model><in vivo><in vivo evaluation><in vivo testing><innovate><innovation><innovative><intervention efficacy><kidney toxicity><malignancy><membrane structure><molecular targeted therapeutics><molecular targeted therapies><molecular targeted treatment><multi-drug resistant><multidisciplinary><multidrug resistant><necrocytosis><neoplasm/cancer><nephrotoxicity><new approaches><novel approaches><novel strategies><novel strategy><overexpress><overexpression><pathway><peptide structure><pre-clinical development><preclinical development><refractory cancer><resistance mechanism><resistance to Drug><resistant><resistant cancer><resistant mechanism><resistant to Drug><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic efficacy><therapy efficacy><trafficking><translation research><translational investigation><translational opportunities><translational potential><triple-negative breast cancer><triple-negative invasive breast carcinoma><tumor><tumor growth><undergrad><undergraduate><undergraduate student><uptake><vitamin Bc><xenograft transplant model><xenotransplant model>
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Pothitos Pitychoutis

UNIVERSITY OF DAYTON, DAYTON, OH

Exploratory lead · 20/100
Solid budget
Active award
$413,681
FY 2024

Project Title

Deciphering the Thalamic Reticular Functions of Phospholamban

Grant Number:

1R15MH136640-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2024

End Date:

7/14/2027

Project Abstract

PROJECT SUMMARY The thalamic reticular nucleus (TRN) is a poorly understood structure of the mammalian forebrain that is deeply involved in regulating complex behaviors such as sensory processing, attention, and sleep. TRN dysfunction has been recently proposed to comprise a circuit endophenotype in...

Research Terms

<4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><AD/HD><ADHD><ASD><ATP phosphohydrolase (Ca(2+)-transporting)><Ablation><Address><Affect><Aminalon><Aminalone><Antibodies><Applications Grants><Attention><Attention deficit hyperactivity disorder><Autism><Autistic Disorder><Autoregulation><Award><Behavior><Behavioral><Bio-Informatics><Bioinformatics><Biology><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain region><Ca(2+)-Transporting ATPase><Ca2+ ATPase><Ca2+ transporting ATPase><Calcium><Calcium ATPase><Calcium Adenosine Triphosphatase><Calcium Ion Signaling><Calcium Pump><Calcium Signaling><Cardiac><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cell Body><Cell Communication and Signaling><Cell Nucleus><Cell Signaling><Cells><Complex><Cre-Lox><Cre-LoxP><Cre/LoxP><Cyclicity><Data><Dendrites><Detection><Development><Dysfunction><Early Infantile Autism><Encephalon><Encephalon Diseases><Endoplasmic Reticulum><Ergastoplasm><Exposure to><Fiber><Fore-Brain><Forebrain><Functional disorder><GABA><Gene Transcription><Genetic><Genetic Transcription><Goals><Grant Proposals><HPLC><Heart><Heart Vascular><High Performance Liquid Chromatography><High Pressure Liquid Chromatography><High Speed Liquid Chromatography><High-Throughput RNA Sequencing><Homeostasis><Hyperactive behavior><Hyperactivity><Image><Impulsive Behavior><Impulsivity><In vivo two-photon calcium imaging><Infantile Autism><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Investigators><KO mice><Kanner's Syndrome><Knock-out Mice><Knockout Mice><Leanness><Locomotor Activity><Maps><Mediating><Methodology><Mice><Mice Mammals><Mission><Molecular><Molecular Dynamics Simulation><Motor><Motor Activity><Motor Hyperactivity><Murine><Mus><NIH><National Institutes of Health><Nerve Cells><Nerve Unit><Neural Cell><Neurobiology><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><Neurosciences><Neurosciences Research><Nucleus><Null Mouse><Parvalbumins><Pathway interactions><Periodicity><Photometry><Physiological Homeostasis><Physiology><Physiopathology><Population><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Process><Property><Prosencephalon><Proteins><Protocol><Protocols documentation><Public Health><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Reaction Time><Reagent><Regulation><Research><Research Personnel><Researchers><Response RT><Response Time><Rhythmicity><Role><Schizophrenia><Schizophrenic Disorders><Science><Sensory><Signal Transduction><Signal Transduction Systems><Signaling><Sleep><Solid><Structure><Students><Testing><Thalamic structure><Thalamus><Thinness><Transcription><Transgenic Mice><Transgenic Organisms><United States National Institutes of Health><Universities><Viral><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><behavior phenotype><behavioral phenotyping><biological signal transduction><calcium indicator><calcium transporting ATPase><circulatory system><cost><dementia praecox><developmental><endophenotype><experiment><experimental research><experimental study><experiments><field based data><field learning><field study><field test><fluorophore><gamma-Aminobutyric Acid><gene network><graduate student><imaging><imaging approach><imaging based approach><in vivo><in vivo calcium imaging><innovate><innovation><innovative><insight><lab curriculum><laboratory course><laboratory curriculum><molecular dynamics><mouse model><murine model><neural circuit><neural circuitry><neurobiological><neurochemical><neurochemistry><neurocircuitry><neurodevelopmental disease><neuronal><neurophysiological><neurophysiology><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><patch clamp><pathophysiology><pathway><phospholamban><preservation><psychomotor reaction time><response><schizophrenic><scientific literacy><scientifically literate><selective expression><selectively expressed><social role><synaptic circuit><synaptic circuitry><thalamic><tool><transcriptome profiling><transcriptome sequencing><transcriptomic profiling><transcriptomic sequencing><transcriptomics><transgenic><undergrad><undergraduate><undergraduate student><γ-Aminobutyric Acid>
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Rajesh Nagarajan

BOISE STATE UNIVERSITY, BOISE, ID

Exploratory lead · 20/100
Solid budget
Active award
$408,579
FY 2022

Project Title

Chemical probes to modulate acyl-homoserine lactone quorum signal synthesis

Grant Number:

1R15GM148920-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/20/2022

End Date:

8/31/2026

Project Abstract

Abstract Gram-negative bacteria count specific, N-acyl-L-homoserine lactone (AHL) quorum sensing (QS) signals in the environment to estimate local population densities, facilitate cell-cell communication and virulence. AHL synthases make AHL autoinducer signals by enzymatically coupling acyl-ACP/acy...

Research Terms

<Academic Research Enhancement Awards><Active Sites><Acyl Carrier Protein><Acyl CoA><Acyl Coenzyme A><Ademetionine><AdoMet><Allosteric Site><Applications Grants><Assay><Bacteria><Binding><Bioassay><Biologic Assays><Biological Assay><Biomedical Research><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Interaction><Cell Signaling><Cell-to-Cell Interaction><Cells><Chemicals><CoA><Coenzyme A><Coupling><Data><Diffuse><Docking><Environment><Enzyme Gene><Enzymes><Exposure to><Fatty Acyl CoA><Foundations><Funding><Future><Goals><Gram-Negative Bacteria><Grant><Grant Proposals><HPLC><High Performance Liquid Chromatography><High Pressure Liquid Chromatography><High Speed Liquid Chromatography><Home><Homocysteine><In Vitro><Institution><Interruption><Intracellular Communication and Signaling><Kinetics><Libraries><Long-Chain Acyl CoA><MDR organism><MDR pathogen><Maps><Mediating><Molecular><Molecular Interaction><NIGMS><NIH><National Institute of General Medical Sciences><National Institutes of Health><Outcome><P aeruginosa><P. aeruginosa><Pathogenicity><Physicians><Pilot Projects><Population Density><Proteins><Pseudomonas aeruginosa><Pseudomonas pyocyanea><R15 Mechanism><R15 Program><Receptor Protein><Research><Research Infrastructure><S-Adenosylmethionine><SAMe><Signal Transduction><Signal Transduction Systems><Signaling><Specificity><Substrate Specificity><Testing><Training><United States National Institutes of Health><Virulence><analog><biochemical tools><biochemistry tools><biological signal transduction><career><design><designing><homoserine lactone><in vivo><infection rate><inhibitor><multi-drug resistant organism><multi-drug resistant pathogen><multidrug resistant organism><multidrug resistant pathogen><multiple drug resistant organism><multiple drug resistant pathogen><novel><pilot study><programs><quorum sensing><rate of infection><rational design><receptor><s-adenosyl-l-methionine><small molecule><small molecule inhibitor><tool><undergrad><undergraduate><undergraduate student>
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Qinghua Yang

TEXAS CHRISTIAN UNIVERSITY, FORT WORTH, TX

Exploratory lead · 20/100
Solid budget
Active award
$407,581
FY 2025

Project Title

Examining the mediating and moderating factors in the relationships between social media engagement and ENDS use and dependence among young adults

Grant Number:

1R15CA290615-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT Electronic nicotine delivery systems (ENDS) use by young adults has substantially increased in the last few years and surpassed that of older adults in 2014. Recent years have witnessed a shift in promotion of ENDS products from traditional media to social media (SM). Young ...

Research Terms

<Accounting><Advertising><Behavior><Belief><Benefits and Risks><Cigar><Cigarette><Cognition><Cognitive><Data><Data Analyses><Data Analysis><Dependence><Depressed mood><Dose><Electronic Nicotine Delivery Product><Electronic Nicotine Delivery Systems><Emotional Depression><Exposure to><Female><Friends><Future><Goals><Investigators><Literature><Longitudinal Studies><Mediating><Mediator><Mental Depression><Mentorship><Oral><Outcome><Pathway interactions><Policy Making><Predisposition><Reporting><Research><Research Design><Research Personnel><Researchers><Risk><Social Network><Socialization><Study Type><Subgroup><Survey Instrument><Surveys><Susceptibility><Testing><Tobacco><Tobacco Consumption><Tobacco Dependence><Tobacco use><Training><Writing><adult youth><age group><career><cohort><data interpretation><depressed><depression><depression symptom><depressive><depressive symptoms><desensitization><design><designing><electronic nicotine delivery device><electronic nicotine distribution system><engaging with social media><graduate student><high risk><long-term study><longitudinal outcome studies><older adult><older adulthood><pathway><peer><pilot test><prevent><preventing><recruit><sadness><sex><social media><social media activity><social media engagement><social media use><social norm><socio-demographics><sociodemographics><study design><tailored messaging><tobacco addiction><tobacco dependent><tobacco product use><tobacco products><undergrad><undergraduate><undergraduate student><utilize social media><young adult><young adult age><young adulthood><♀>
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Mehmet Kaya

FLORIDA INSTITUTE OF TECHNOLOGY, MELBOURNE, FL

Exploratory lead · 20/100
Solid budget
Active award
$406,221
FY 2025

Project Title

A Novel, Low-Cost, Machine Learning based and Wearable Technology for Monitoring Heart Failure Parameters

Grant Number:

1R15HL175648-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2025

End Date:

8/31/2028

Project Abstract

Heart failure (HF) is a leading cause of mortality, with a low five-year survival rate, often requiring frequent hospitalizations. Remote cardiac monitoring has improved HF management, yet a crucial gap remains in monitoring the heart's pumping function, specifically Left Ventricular Function (LVF) ...

Research Terms

<3-D><3-Dimensional><3D><AI system><Accelerometer><Address><Ambulatory Monitoring><Artificial Heart><Artificial Intelligence><Biomedical Research><Cardiac><Cardiac Output><Cardiology><Cell Communication and Signaling><Cell Signaling><Computer Analysis><Computer Models><Computer Reasoning><Computerized Models><Data><Data Analyses><Data Analysis><Death Rate><Dedications><Dysfunction><Echocardiogram><Echocardiography><Echography><Echotomography><Economic Burden><Elements><Enhancement Technology><Ensure><Evaluation><Florida><Functional disorder><Goals><Grant><Health Care Costs><Health Care Systems><Health Costs><Heart><Heart failure><Hospital Admission><Hospitalization><Image><Intracellular Communication and Signaling><LVEF><Left Ventricles><Left Ventricular Ejection Fraction><Left Ventricular Function><Left ventricular structure><Link><Liquid substance><Machine Intelligence><Machine Learning><Measurement><Measures><Mechanics><Medical Ultrasound><Methodology><Methods><Modeling><Monitor><Morphology><Motion><Movement><Myocardial><Outpatient Monitoring><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Phase><Physiopathology><Population><Prognosis><Pump><QOL><Quality of life><Recurrence><Recurrent><Research><Research Infrastructure><Risk><Signal Transduction><Signal Transduction Systems><Signaling><Sorting><Stroke Volume><Survival Rate><System><Techniques><Technology><Testing><Thermodilution><Thermodilutions><Time><Transthoracic Echocardiography><Ultrasonic Imaging><Ultrasonogram><Ultrasonography><Ultrasound Diagnosis><Ultrasound Medical Imaging><Ultrasound Test><Universities><Variant><Variation><Work><accelerometry><activity monitor><activity tracker><base><bases><biological signal transduction><body movement><cardiac MRI><cardiac failure><cardiac imaging><cardiac magnetic resonance imaging><cardiac prosthesis><cardiac scanning><computational analyses><computational analysis><computational modeling><computational models><computer analyses><computer based models><computerized modeling><continuous monitoring><cost><cost effective><data interpretation><diagnostic ultrasound><experimental analysis><feature extraction><feature selection><fluid><heart imaging><heart output><heart prosthesis><heart scanning><heart sonography><hemodynamics><hospitalization rates><human disease><human subject><image processing><imaging><improved><innovate><innovation><innovative><interdisciplinary approach><liquid><machine based learning><mechanic><mechanical><mechanical heart><mortality><mortality rate><mortality ratio><multidisciplinary approach><novel><pathophysiology><patient oriented outcomes><patient response><patient specific response><prosthetic heart><remote monitoring><respiratory><responsive patient><sensor><sonogram><sonography><sound measurement><student engagement><student motivation><student participation><three dimensional><ultrasound imaging><ultrasound scanning><undergrad><undergraduate><undergraduate student><vibration><wearable><wearable device><wearable electronics><wearable system><wearable technology><wearable tool><wearables>
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Peshala Thibbotuwawa Gamage

FLORIDA INSTITUTE OF TECHNOLOGY, MELBOURNE, FL

Exploratory lead · 20/100
Solid budget
Active award
$406,221
FY 2025

Project Title

A Novel, Low-Cost, Machine Learning based and Wearable Technology for Monitoring Heart Failure Parameters

Grant Number:

1R15HL175648-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2025

End Date:

8/31/2028

Project Abstract

Heart failure (HF) is a leading cause of mortality, with a low five-year survival rate, often requiring frequent hospitalizations. Remote cardiac monitoring has improved HF management, yet a crucial gap remains in monitoring the heart's pumping function, specifically Left Ventricular Function (LVF) ...

Research Terms

<3-D><3-Dimensional><3D><AI system><Accelerometer><Address><Ambulatory Monitoring><Artificial Heart><Artificial Intelligence><Biomedical Research><Cardiac><Cardiac Output><Cardiology><Cell Communication and Signaling><Cell Signaling><Computer Analysis><Computer Models><Computer Reasoning><Computerized Models><Data><Data Analyses><Data Analysis><Death Rate><Dedications><Dysfunction><Echocardiogram><Echocardiography><Echography><Echotomography><Economic Burden><Elements><Enhancement Technology><Ensure><Evaluation><Florida><Functional disorder><Goals><Grant><Health Care Costs><Health Care Systems><Health Costs><Heart><Heart failure><Hospital Admission><Hospitalization><Image><Intracellular Communication and Signaling><LVEF><Left Ventricles><Left Ventricular Ejection Fraction><Left Ventricular Function><Left ventricular structure><Link><Liquid substance><Machine Intelligence><Machine Learning><Measurement><Measures><Mechanics><Medical Ultrasound><Methodology><Methods><Modeling><Monitor><Morphology><Motion><Movement><Myocardial><Outpatient Monitoring><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Phase><Physiopathology><Population><Prognosis><Pump><QOL><Quality of life><Recurrence><Recurrent><Research><Research Infrastructure><Risk><Signal Transduction><Signal Transduction Systems><Signaling><Sorting><Stroke Volume><Survival Rate><System><Techniques><Technology><Testing><Thermodilution><Thermodilutions><Time><Transthoracic Echocardiography><Ultrasonic Imaging><Ultrasonogram><Ultrasonography><Ultrasound Diagnosis><Ultrasound Medical Imaging><Ultrasound Test><Universities><Variant><Variation><Work><accelerometry><activity monitor><activity tracker><base><bases><biological signal transduction><body movement><cardiac MRI><cardiac failure><cardiac imaging><cardiac magnetic resonance imaging><cardiac prosthesis><cardiac scanning><computational analyses><computational analysis><computational modeling><computational models><computer analyses><computer based models><computerized modeling><continuous monitoring><cost><cost effective><data interpretation><diagnostic ultrasound><experimental analysis><feature extraction><feature selection><fluid><heart imaging><heart output><heart prosthesis><heart scanning><heart sonography><hemodynamics><hospitalization rates><human disease><human subject><image processing><imaging><improved><innovate><innovation><innovative><interdisciplinary approach><liquid><machine based learning><mechanic><mechanical><mechanical heart><mortality><mortality rate><mortality ratio><multidisciplinary approach><novel><pathophysiology><patient oriented outcomes><patient response><patient specific response><prosthetic heart><remote monitoring><respiratory><responsive patient><sensor><sonogram><sonography><sound measurement><student engagement><student motivation><student participation><three dimensional><ultrasound imaging><ultrasound scanning><undergrad><undergraduate><undergraduate student><vibration><wearable><wearable device><wearable electronics><wearable system><wearable technology><wearable tool><wearables>
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Carol Ann Chrestensen

KENNESAW STATE UNIVERSITY, KENNESAW, GA

Exploratory lead · 20/100
Solid budget
Active award
$405,650
FY 2023

Project Title

NOS3 and p38 MAP kinase - is the interaction between them a mechanism of p38 regulation?

Grant Number:

1R15GM147866-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2023

End Date:

8/31/2026

Project Abstract

Project Summary Nitric Oxide Synthase 3 (NOS3) and p38α play key roles in intracellular signaling. Alterations to the activity of these enzymes impact diseases like atherosclerosis, diabetes, and cancer. p38 is ubiquitously expressed, very near the end of the signaling cascades it functions in and b...

Research Terms

<ASVSRC1><Affect><Affinity><Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg><Assay><Atheroscleroses><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Autoregulation><Binding><Binding Sites><Bioassay><Biologic Assays><Biological><Biological Assay><Blood Vessels><Bradykinin><C-jun Amino-Terminal Kinase><C-jun Kinase-1><C-jun N-Terminal Kinase 1><CSAID-Binding Protein 1><CSAID-Binding Protein 2><CSBP2><Cancers><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cellular Immune Function><Closure by Ligation><Combining Site><Cysteine><Cytokine-Suppressive Antiinflammatory Drug-Binding Protein 1><Cytokine-Suppressive Antiinflammatory Drug-Binding protein 2><Diabetes Mellitus><Dimerization><Disease><Disorder><E coli><E. coli><EDRF Synthase><ENOS><Endogenous Nitrate Vasodilator><Endothelial Cells><Endothelial Nitric Oxide Synthase><Endothelium-Derived Growth Factor Synthase><Endothelium-Derived Nitric Oxide><Environment><Enzyme Gene><Enzymes><Escherichia coli><Event><Family><Family member><Guanylyl Cyclase-Activating Factor Synthase><Half-Cystine><Homeostasis><Humulin R><INOS><In Situ><In Vitro><Inducible Nitric Oxide Synthase><Insulin><Interferometry><Intracellular Communication and Signaling><Investigators><JN Kinase><JNK><JNK Mitogen-Activated Protein Kinases><JNK1><JNK1 Kinase><JNK1 protein><JNK1A2><JNK21B1/2><Kinases><L-Cysteine><Ligation><Location><MAP Kinase 8><MAP Kinase 8 Gene><MAP kinase><MAPK14><MAPK14 Mitogen-Activated Protein Kinase><MAPK14 gene><MAPK8><MAPK8 Mitogen-Activated Protein Kinase><MAPK8 gene><Macrophage Nitric Oxide Synthase><Malignant Neoplasms><Malignant Tumor><Mitogen-Activated Protein Kinase 14><Mitogen-Activated Protein Kinase 8><Mitogen-Activated Protein Kinases><Modification><Molecular><Molecular Interaction><Mononitrogen Monoxide><Mxi2><N-terminal><NH2-terminal><NO Synthase><NOS1><NOS1 gene><NOS2><NOS2A><NOS2A gene><NOS2A, Inducible, Hepatocyte><NOS3><NOS3 gene><Nature><Neural Transmission><Nitric Oxide><Nitric Oxide Synthase><Nitric Oxide Synthase 2A><Nitric Oxide Synthase 3><Nitric-Oxide Synthetase><Nitrogen Monoxide><Nitrogen Protoxide><Novolin R><Organism-Level Process><Organismal Process><Outcome><Output><PKA inhibitor><PRKM8><Pathway interactions><Peptides><Phosphorylation><Phosphorylation Site><Phosphotransferase Gene><Phosphotransferases><Physiologic><Physiologic Processes><Physiological><Physiological Homeostasis><Physiological Processes><Play><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Process><Production><Protein Dimerization><Protein Kinase Interaction><Protein Modification><Protein Phosphorylation><Proteins><Reactive Site><Regular Insulin><Regulation><Research><Research Personnel><Researchers><Rest><Role><Running><SAP Kinase-1><SAPK/JNK><SAPK1 Mitogen-Activated Protein Kinase><SAPK1/JNK><SAPK2A><SRC Family Gene><SRC gene><STEM class><STEM course><STEM discipline><STEM field><STEM major><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Site><Stimulus><Stress-Activated Protein Kinase 2A><Stress-Activated Protein Kinase JNK1><Stress-Activated Protein Kinase gamma><Surface><Synaptic Transmission><Testing><Transphosphorylases><Type III nitric oxide synthase><VEGF><VEGFs><Variant><Variation><Vascular Endothelial Growth Factors><Vasodilatation><Vasodilation><Vasorelaxation><atheromatosis><atherosclerotic disease><atherosclerotic vascular disease><biologic><biological signal transduction><c src><c-jun N-Terminal Kinase><c-src Genes><c-src Proto-Oncogenes><career><diabetes><dimer><endothelial cell derived relaxing factor><enzyme activity><experiment><experimental research><experimental study><experiments><immune function><in vitro activity><inhibitor><jun-NH2-Terminal Kinase><kallidin 9><kallidin I><malignancy><member><nano-molar><nanomolar><neoplasm/cancer><oxidation><p38><p38 MAP Kinase><p38 MAPK Gene><p38 Mitogen Activated Protein Kinase><p38 Protein Kinase><p38 SAPK><p38-Alpha><p38Alpha><pathway><protein protein interaction><recruit><response><scaffold><scaffolding><science, technology, engineering and math class><science, technology, engineering and math course><science, technology, engineering and math discipline><science, technology, engineering and math field><science, technology, engineering and math major><science, technology, engineering and mathematics class><science, technology, engineering and mathematics course><science, technology, engineering and mathematics discipline><science, technology, engineering and mathematics field><science, technology, engineering and mathematics major><social role><stress-activated protein kinase 1><success><time use><undergrad><undergraduate><undergraduate student><v-SRC Avian Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog><vascular>
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Christo Zhivkov Christov

MICHIGAN TECHNOLOGICAL UNIVERSITY, HOUGHTON, MI

Exploratory lead · 20/100
Solid budget
Active award
$403,453
FY 2024

Project Title

Understanding Catalytic Mechanisms of Human Non-Heme Fe(II) and 2-Oxoglutarate-Dependent Histone Demethylases

Grant Number:

2R15GM139118-02

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2021

End Date:

7/31/2027

Project Abstract

PROJECT SUMMARY Epigenetic regulation is one of eukaryotic cells' most central and complex processes. Enzymatic demethylation of N𝜀-methylated lysine residues in histone proteins is performed almost exclusively by non-heme Fe(II) and 2-oxoglutarate (2OG) - dependent histone demethylases (KDMs). KDM...

Research Terms

<2-ketoglutarate><2-oxoglutarate><Academic Research Enhancement Awards><Active Sites><Affect><Award><Basic Research><Basic Science><Binding><Binding Sites><Biochemistry><Bioinorganic Chemistry><Biological Chemistry><Biological Function><Biological Process><Catalysis><Chemicals><Combining Site><Complex><Computer Models><Computerized Models><Dealkylation><Dioxygen><Distant><Drug Design><Drugs><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Eukaryotic Cell><Foundations><Genetic Diseases><Goals><H-bond><Histones><Human><Hydrogen Bonding><Hydroxylation><L-Lysine><Link><Lysine><Medication><Methods><Methylation><Mission><Modern Man><Modernization><Molecular><Molecular Interaction><Motion><NIGMS><NIH><National Institute of General Medical Sciences><National Institutes of Health><Nature><Other Genetics><Pathologic Processes><Pathological Processes><Pharmaceutical Preparations><Position><Positioning Attribute><Prevention><Process><Proteins><R15 Mechanism><R15 Program><Reaction><Reactive Site><Research><Rotation><Site><Specificity><Structure><Substrate Interaction><Substrate Specificity><Techniques><Testing><United States National Institutes of Health><alkyl group><alpha ketoglutarate><alpha-oxoglutarate><cancer genetics><computational modeling><computational models><computer based models><computerized modeling><demethylation><design><designing><disease diagnosis><drug/agent><electronic structure><enzyme substrate><epigenetic drug><epigenetic modifying drugs><epigenetic regulation><epigenetically><experience><experiment><experimental research><experimental study><experiments><genetic condition><genetic disorder><geometric structure><histone demethylase><inhibitor><insight><methyl group><novel><oxidation><prevent><preventing><structural geometry><synergism><undergrad><undergraduate><undergraduate student><α-ketoglutarate><α-oxoglutarate><αKG>
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Joshua Ruppel

DAVIDSON COLLEGE, DAVIDSON, NC

Exploratory lead · 20/100
Solid budget
Active award
$402,695
FY 2022

Project Title

Synthesis of Carbohydrate-Phthalocyanine Conjugates for Biomedical Applications

Grant Number:

1R15GM148916-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2022

End Date:

8/31/2026

Project Abstract

PROJECT SUMMARY Phthalocyanines are macrocycles that meet all the criteria for an effective photosensitizer including absorption in the near infrared region between 700-1100nm for deep tissue penetration, and high singlet oxygen generation for maximum cell killing. However, the same properties that ...

Research Terms

<Acetylgalactosamine><Active Oxygen><Address><Amines><Award><Binding><Biologic Models><Biological><Biological Models><Body Tissues><Cancer Treatment><Carbohydrates><Cell Death><Cell surface><Chemistry><Clinical><Collaborations><Development><Effectiveness><Electrons><Energy Transfer><Enzyme Gene><Enzymes><Evaluation><Exhibits><Fostering><Generations><Glycoconjugates><Hepatic Cells><Hepatic Parenchymal Cell><Hepatocarcinoma><Hepatocellular Carcinoma><Hepatocellular cancer><Hepatocyte><Hepatoma><Hydrogen Oxide><Hydrophobicity><Hydroxides><Infection><Institution><Intermediary Metabolism><Lead><Lectin><Libraries><Light><Lipid Peroxidation><Liquid substance><Liver Cells><Liver Cells Carcinoma><M smegmatis><M tb><M tuberculosis><M tuberculosis infection><M. smegmatis><M. tb><M. tb infection><M. tuberculosis><M. tuberculosis infection><M.tb infection><M.tuberculosis infection><MTB infection><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Metabolic Processes><Metabolism><Methodology><Methods><Model System><Molecular><Molecular Interaction><Mycobacterium smegmatis><Mycobacterium tuberculosis><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><N acetylgalactosamine><NIH><National Institutes of Health><Negative Beta Particle><Negatrons><O element><O2 element><Oxygen><Oxygen Radicals><PUVA><PUVA Photochemotherapy><Pb element><Penetration><Pharmacology><Photochemotherapy><Photodynamic Therapy><Photoradiation><Photosensitizers><Photosensitizing Agents><Play><Preparation><Primary carcinoma of the liver cells><Pro-Oxidants><Property><Protocol><Protocols documentation><Public Health><Reaction><Reactive Oxygen Species><Receptor Protein><Research><Research Resources><Resources><Series><Singlet Dioxygen><Singlet Oxygen><Solubility><Sulfate><Superoxide Anion><Superoxide Radical><Superoxides><System><TB infection><Therapeutic><Time><Tissues><Training><Trehalose><Tuberculosis><United States National Institutes of Health><Water><Work><absorption><amine><analog><anti-cancer therapy><anticancer therapy><base><biologic><biological systems><cancer therapy><cancer-directed therapy><cell killing><college><collegiate><design><designing><developmental><disseminated TB><disseminated tuberculosis><experience><fluid><heavy metal Pb><heavy metal lead><improved><infection due to Mycobacterium tuberculosis><innovate><innovation><innovative><liquid><liver carcinoma><microbial><mtb><necrocytosis><neoplasm/cancer photoradiation therapy><next generation><overexpress><overexpression><photosensitizer><phthalocyanine><receptor><success><triplet state><tuberculosis infection><tuberculous spondyloarthropathy><undergrad><undergraduate><undergraduate research><undergraduate student>
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Nicole Leigh Snyder-Lee

DAVIDSON COLLEGE, DAVIDSON, NC

Exploratory lead · 20/100
Solid budget
Active award
$402,695
FY 2022

Project Title

Synthesis of Carbohydrate-Phthalocyanine Conjugates for Biomedical Applications

Grant Number:

1R15GM148916-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2022

End Date:

8/31/2026

Project Abstract

PROJECT SUMMARY Phthalocyanines are macrocycles that meet all the criteria for an effective photosensitizer including absorption in the near infrared region between 700-1100nm for deep tissue penetration, and high singlet oxygen generation for maximum cell killing. However, the same properties that ...

Research Terms

<Acetylgalactosamine><Active Oxygen><Address><Amines><Award><Binding><Biologic Models><Biological><Biological Models><Body Tissues><Cancer Treatment><Carbohydrates><Cell Death><Cell surface><Chemistry><Clinical><Collaborations><Development><Effectiveness><Electrons><Energy Transfer><Enzyme Gene><Enzymes><Evaluation><Exhibits><Fostering><Generations><Glycoconjugates><Hepatic Cells><Hepatic Parenchymal Cell><Hepatocarcinoma><Hepatocellular Carcinoma><Hepatocellular cancer><Hepatocyte><Hepatoma><Hydrogen Oxide><Hydrophobicity><Hydroxides><Infection><Institution><Intermediary Metabolism><Lead><Lectin><Libraries><Light><Lipid Peroxidation><Liquid substance><Liver Cells><Liver Cells Carcinoma><M smegmatis><M tb><M tuberculosis><M tuberculosis infection><M. smegmatis><M. tb><M. tb infection><M. tuberculosis><M. tuberculosis infection><M.tb infection><M.tuberculosis infection><MTB infection><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Metabolic Processes><Metabolism><Methodology><Methods><Model System><Molecular><Molecular Interaction><Mycobacterium smegmatis><Mycobacterium tuberculosis><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><N acetylgalactosamine><NIH><National Institutes of Health><Negative Beta Particle><Negatrons><O element><O2 element><Oxygen><Oxygen Radicals><PUVA><PUVA Photochemotherapy><Pb element><Penetration><Pharmacology><Photochemotherapy><Photodynamic Therapy><Photoradiation><Photosensitizers><Photosensitizing Agents><Play><Preparation><Primary carcinoma of the liver cells><Pro-Oxidants><Property><Protocol><Protocols documentation><Public Health><Reaction><Reactive Oxygen Species><Receptor Protein><Research><Research Resources><Resources><Series><Singlet Dioxygen><Singlet Oxygen><Solubility><Sulfate><Superoxide Anion><Superoxide Radical><Superoxides><System><TB infection><Therapeutic><Time><Tissues><Training><Trehalose><Tuberculosis><United States National Institutes of Health><Water><Work><absorption><amine><analog><anti-cancer therapy><anticancer therapy><base><biologic><biological systems><cancer therapy><cancer-directed therapy><cell killing><college><collegiate><design><designing><developmental><disseminated TB><disseminated tuberculosis><experience><fluid><heavy metal Pb><heavy metal lead><improved><infection due to Mycobacterium tuberculosis><innovate><innovation><innovative><liquid><liver carcinoma><microbial><mtb><necrocytosis><neoplasm/cancer photoradiation therapy><next generation><overexpress><overexpression><photosensitizer><phthalocyanine><receptor><success><triplet state><tuberculosis infection><tuberculous spondyloarthropathy><undergrad><undergraduate><undergraduate research><undergraduate student>
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Kassim Traore

DUQUESNE UNIVERSITY, PITTSBURGH, PA

Exploratory lead · 20/100
Solid budget
Active award
$401,895
FY 2023

Project Title

Title: In Vitro Analysis of the Effects of Acute and Chronic Phthalate Exposures on Leydig Cell Testosterone Production, and the Molecular Mechanisms Involved

Grant Number:

2R15ES032102-03

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

8/31/2026

Project Abstract

Project Summary By interfering with normal hormonal function and action, endocrine-disrupting chemicals (EDCs) such as the plasticizer di-(2-ethylhexyl) phthalate (DEHP) can have negative effects on the male reproductive system. In previous studies, Dr. Traore found that in utero exposure to DEHP ca...

Research Terms

<21+ years old><Acute><Address><Adult><Adult Human><Affect><Amniotic Fluid><Animals><Antioxidants><Aqua Amnii><Attention><Baby Formula><Basic Research><Basic Science><Blood Serum><Breast Milk><Breastmilk><CCL21><CCL21 gene><CKb9><Cell Body><Cell Isolation><Cell Line><Cell Segregation><Cell Separation><Cell Separation Technology><CellLine><Cells><Chemicals><Chloroethylene Homopolymer><Chloroethylene Polymer><Cholesterol><Chronic><Clinical Research><Clinical Study><Common Rat Strains><Cord Blood><Corpus Luteum Hormone><Cosmetics><Cryptorchidism><Cryptorchism><Defect><Delta4-pregnene-3,20-dione><Development><Diabetes Mellitus><Dose><Drugs><Endocrine Disrupter><Endocrine Disrupting Chemicals><Endocrine Disruptors><Endocrine Gland Secretion><Endocrine disrupting agent><Environment><Equilibrium><Ethene, chloro-, homopolymer><Exposure to><Faculty><Funding><Genital system><Grant><Hormonal><Hormones><Human Milk><Human Mother's Milk><Hypospadias><In Vitro><Industrialization><Infant formula><Institution><Interstitial Cell Neoplasm><Interstitial Cell Stimulating Hormone><Interstitial Cell Tumor><Interstitial Cell-Stimulating Hormone><Laboratories><Leuteinizing Hormone><Leydig Cell Neoplasm><Leydig Cell Tumor><Leydig Cells><Life><Life Cycle><Life Cycle Stages><Liquor Amnii><Long-Term Effects><Longitudinal Studies><Longterm Effects><Luteinizing Hormone><Lutropin><MD students><MGC34555><Male Genital Organs><Male Genital System><Male Genitalia><Malignant Testicular Neoplasm><Malignant Testicular Tumor><Malignant Tumor of the Testis><Malignant neoplasm of testis><Mammary Gland Milk><Mediating><Medical Students><Medication><Methods><Mice><Mice Mammals><Mitochondria><Molecular><Molecular Weight><Mother's Milk><Mouse Strains><Murine><Mus><North Carolina><Obesity><Oxidants><Oxidation-Reduction><Oxidizing Agents><Persons><Pharmaceutic Preparations><Pharmaceutical Preparations><Pituitary Lutenizing Hormone><Plasticizers><Play><Polychloroethylene><Polymers><Polyvinyl Chloride><Predisposition><Pregn-4-ene-3,20-dione><Pregnenedione><Production><Progenitor Cells><Progesterone><Proliferating><Proteins><Public Health Schools><Rat><Rats Mammals><Rattus><Recombinant Luteinizing Hormone><Redox><Reporting><Reproductive system><Research><Risk Factors><Role><Rural><SCYA21><SLC><Secondary to><Seminiferous Tubules><Seminiferous tubule structure><Serum><Stem Cell Development><Steroid Compound><Steroids><Strains Cell Lines><Students><Surface><Susceptibility><System><TCA4><Testicles><Testicular Cancer><Testicular Interstitial Cells><Testis><Testis Cancer><Testosterone><Therapeutic Hormone><Therapeutic LH><Therapeutic Progesterone><Therapeutic Testosterone><Time><Toxicant exposure><Training><Trans-Testosterone><Umbilical Cord Blood><Undescended Testis><Universities><Vinyl Chloride Polymer><adiposity><adulthood><aged><anti-oxidant><balance><balance function><cell sorting><consumer product><corpulence><cosmetic product><cultured cell line><developmental><diabetes><diet supplement><dietary supplements><drug/agent><electron acceptor><endocrine disrupting compound><environmental stresses><environmental stressor><exposed in utero><fetal cord blood><fetal exposure><flexibility><flexible><graduate student><in utero exposure><in vivo><insight><interest><intra-uterine environmental exposure><intrauterine environmental exposure><leydig interstitial cell><life course><long-term study><longitudinal outcome studies><longterm study><male><male genital><male reproductive body system><male reproductive organ system><male reproductive system><maternal milk><medical school students><milk formula><mitochondrial><negative affect><negative affectivity><neonatal exposure><nutritional supplement><oxidation reduction reaction><phthalates><polymer><polymeric><polyvinylchloride><prenatal exposure><prenatally exposed><progenitor cell development><programs><response><self-renew><self-renewal><social role><stem><stem cell differentiation><stem cells><success><testis interstitial cell><toxic exposure><under served area><under served geographic area><under served location><under served region><undergrad><undergraduate><undergraduate student><underserved area><underserved geographic area><underserved location><underserved region><undescended testicles><vinylchloride polymer>
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Lauren L Williamson

NORTHERN KENTUCKY UNIVERSITY, HIGHLAND HEIGHTS, KY

Exploratory lead · 20/100
Solid budget
Active award
$400,733
FY 2022

Project Title

A role for maternal helminth treatment to alter central inflammation and to reduce lifelong offspring inflammation

Grant Number:

1R15MH132060-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/20/2022

End Date:

8/31/2026

Project Abstract

PROJECT SUMMARY Neuroinflammation is correlated with a broad spectrum of disorders, including cognitive and mental health disorders. Treating and reducing neuroinflammation remains a medical challenge. The purpose of this research is to determine the effects of maternal helminth colonization on her ...

Research Terms

<0-4 weeks old><12-20 years old><21+ years old><ARHGEF5><ARHGEF5 gene><Academic Research Enhancement Awards><Acute><Adolescence><Adult><Adult Children><Adult Daughters><Adult Human><Adult Offspring><Adult Sons><Adverse Experience><Adverse event><Affect><Ammon Horn><Animal Model><Animal Models and Related Studies><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Antiinflammatories><Antiinflammatory Agents><Antiinflammatory Effect><Anxiety><Astrocytes><Astrocytus><Astroglia><Attenuated><Autism><Autistic Disorder><Autoimmune Diseases><Bacterial Infections><Behavior><Behavioral><Behavioral Paradigm><Bio-Informatics><Bioinformatics><Biologic Models><Biological Models><Blood Circulation><Bloodstream><Body Tissues><Brain><Brain Inflammation><Brain Nervous System><CNS Nervous System><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Interaction><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cell Signaling><Cell-to-Cell Interaction><Cells><Central Nervous System><Chronic><Circulation><Cognition><Cognition Disorders><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive deficits><Cognitive function abnormal><Common Rat Strains><Conceptions><Cornu Ammonis><Disease><Disorder><Disseminated Sclerosis><Disturbance in cognition><E coli><E coli Infections><E. coli><E. coli Infections><Early Infantile Autism><Elderly><Encephalitis><Encephalon><Escherichia coli><Escherichia coli Infections><Female><GEF5><Gene Expression><Genes><Genetic><Goals><Health><Helminths><Hippocampus><Hippocampus (Brain)><Hortega cell><Hour><Human><Immune><Immune response><Immunes><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Immunological response><Impaired cognition><Infant><Infantile Autism><Infection><Inflammation><Inflammatory><Intervention><Intervention Strategies><Intracellular Communication and Signaling><Kanner's Syndrome><Laboratories><Learning><Length of Life><Life><Longevity><Measures><Mediating><Medical><Memory><Memory Deficit><Memory impairment><Mental Depression><Mental disorders><Mental health disorders><Microbeads><Microglia><Microspheres><Model System><Modeling><Modern Man><Molecular><Molecular Analysis><Mothers><Multiple Sclerosis><Neonatal><Nerve Cells><Nerve Unit><Neural Cell><Neuraxis><Neurocyte><Neuroimmune><Neurons><Newborn Infant><Newborns><Non-Polyadenylated RNA><Organism><Outcome><P60><Parasites><Parasitic Worms><Pathway interactions><Peripheral><Pharmaceutical Agent><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Physiologic><Physiological><Population><Population Intervention><Psychiatric Disease><Psychiatric Disorder><Psychoneuroimmunology><R15 Mechanism><R15 Program><RNA><RNA Gene Products><RNA Seq><RNA sequencing><RNAseq><Rat><Rats Mammals><Rattus><Research><Ribonucleic Acid><Rodent><Rodentia><Rodents Mammals><Role><Signal Transduction><Signal Transduction Systems><Signaling><Symptoms><TIM1><Techniques><Testing><Time><Tissues><Training><Work><adolescence (12-20)><adulthood><advanced age><anti-inflammatory effect><antiinflammatory><astrocytic glia><autism spectrum disorder><autistic spectrum disorder><autoimmune condition><autoimmune disorder><bacteria infection><bacterial disease><biological signal transduction><cell sorting><cell type><cognitive defects><cognitive disease><cognitive disorder><cognitive dysfunction><cognitive loss><cognitive performance><cognitive syndrome><conditioned fear><cytokine><depression><elders><fascinate><fear conditioning><geriatric><gitter cell><hippocampal><host response><immune system response><immunoresponse><infected neonate><infected newborn><insular sclerosis><interventional strategy><late life><later life><life span><lifespan><living system><mRNA seq><mRNA sequencing><mRNA-seq><mRNAseq><memory dysfunction><mental illness><mesoglia><microglial cell><microgliocyte><model of animal><model organism><neonatal infection><neonatal period><neural><neuroinflammation><neuroinflammatory><neuronal><neuroprotection><newborn child><newborn children><newborn infection><offspring><older adult><older person><pathway><patient population><perivascular glial cell><postnatal><prenatal intervention><prevent><preventing><protective effect><protein expression><psychiatric illness><psychological disorder><psychoneuroimmunological><pup><relating to nervous system><senior citizen><social role><task analysis><transcriptome sequencing><undergrad><undergraduate><undergraduate student>
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Eva-Maria Schoetz Collins

SWARTHMORE COLLEGE, SWARTHMORE, PA

Exploratory lead · 20/100
Solid budget
Active award
$394,942
FY 2023

Project Title

Comparative mechanistic study of developmental neurotoxicity of organophosphorus pesticides

Grant Number:

2R15ES031354-02A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2020

End Date:

5/31/2026

Project Abstract

Organophosphorus pesticides (OPs), a large and chemically diverse class, are the most commonly used and economically important insecticides worldwide, accounting for approximately 40% of recently used insecticides in the U.S. While legal OP concentrations are not acutely toxic to humans, studies sug...

Research Terms

<Accounting><Acetylcholine Hydrolase><Acetylcholinesterase><Acquired brain injury><Acute><Acylcholine acylhydrolase><Acylcholineacylhydrolase><Affect><Amputation><Animals><Behavior><Behavior Disorders><Behavioral><Benchmarking><Best Practice Analysis><Bio-Informatics><Bioinformatics><Brain><Brain Injuries><Brain Nervous System><Butyrylcholinesterase><Chemicals><Chlorpyrifos><Cholinesterases><Chronic><Defect><Development><Developmental Process><Diazinon><Dichlofos><Dichlorophos><Dichlorvos><Dimethyl Dichlorovinyl Phosphate><Dimpylate><Dose><Drug Kinetics><Dugesia><Dugesia (turbellarian)><Encephalon><Environment><Event><Exposure to><Foundations><Fresh Water><Freshwater><Future><Genes><Genetic><Goals><Guidelines><Health><High Throughput Assay><Hour><Human><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Individual><Infant><Insecticides><Karbofos><Kinetics><Knowledge><Legal><Link><Malathion><Mammalia><Mammals><Modern Man><Molecular><Molecular Target><Natural regeneration><Nervous System><Nervous System Injuries><Nervous System Physiology><Nervous System Trauma><Nervous System damage><Neural Development><Neuranatomies><Neuranatomy><Neuroanatomies><Neuroanatomy><Neurologic Body System><Neurologic Organ System><Neurologic function><Neurological Damage><Neurological Injury><Neurological function><Neurological trauma><Outcome><Pathway interactions><Pesticides><Pharmacokinetics><Phenotype><Planarians><Process><RNA Seq><RNA sequencing><RNAseq><Regeneration><Regulation><Research><Sampling><Speed><System><Testing><Time><Toxic effect><Toxicities><Toxicology><Translating><Translations><Work><acetylcholine acetylhydrolase><adverse consequence><adverse outcome><asexual><behavior phenotype><behavior study><behavioral disorder><behavioral phenotyping><behavioral study><benchmark><brain damage><brain-injured><choline esterase I><choline esterase II><cholinergic><combinatorial><comparative><cost><developmental><developmental neurotoxicity><differential expression><differentially expressed><global gene expression><global transcription profile><high throughput screening><innovate><innovation><innovative><nervous system function><neurodevelopment><neuron toxicity><neuronal toxicity><neurotoxicity><neurotrauma><pathway><pesticide exposure><pesticide interaction><pesticide poisoning><pesticide toxicity><prenatal><regenerate><screening><screenings><tool><transcriptional differences><transcriptome><transcriptome sequencing><transcriptomic sequencing><transcriptomics><translation><unborn><undergrad><undergraduate><undergraduate student>
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Elif Isik

TEXAS WOMAN'S UNIVERSITY, DENTON, TX

Exploratory lead · 20/100
Solid budget
Active award
$393,180
FY 2024

Project Title

Asthma Self-Management Behaviors and Cognitive Autonomy: Developing an Adolescent Questionnaire

Grant Number:

1R15HL165313-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/20/2024

End Date:

8/31/2027

Project Abstract

Background and Rationale: Asthma is a substantial public health problem with adolescents having substantial asthma-related morbidity. Adolescence is a critical phase of transition to adulthood, marked by the development of cognitive and autonomous skills required to assume greater responsibility for...

Research Terms

<0-11 years old><12-20 years old><21 year old><21 years of age><21+ years old><Academic Research Enhancement Awards><Address><Adolescence><Adolescent><Adolescent Development><Adolescent Youth><Adult><Adult Human><Age><Asthma><Behavior><Bronchial Asthma><Caring><Characteristics><Charge><Child><Child Youth><Children (0-21)><Clinic><Clinical><Cognitive><Development><Economic Burden><Education><Education for Intervention><Educational Intervention><Educational aspects><Elements><Ensure><Face><Factor Analyses><Factor Analysis><Faculty><Feedback><Frequencies><Goals><Grant><Guidelines><Health><Health Care Costs><Health Costs><Health behavior><Healthcare Costs><High Prevalence><Informal Social Control><Instruction Intervention><Investigators><Learning><Literature><Measures><Methods><Modeling><Monitor><Morbidity><Morbidity - disease rate><NIH><National Institutes of Health><Patient Self-Report><Patients><Phase><Phase Transition><Play><Prevention program><Property><Psychometrics><Public Health><Publishing><QOL><Quality of life><Questionnaires><R15 Mechanism><R15 Program><Research><Research Personnel><Researchers><Respondent><Role><Sampling><Schools><Self Efficacy><Self Management><Self Regulation><Self-Report><Students><Symptoms><Techniques><Testing><Training Intervention><United States National Institutes of Health><Validation><Work><Writing><adolescence (12-20)><adulthood><adulthood transition><age 21><age 21 years><aged><ages><clinical practice><cognitive interview><cognitive process><design><designing><developmental><experience><faces><facial><health related behavior><improved><innovate><innovation><innovative><insight><instructional intervention><interest><juvenile><juvenile human><kids><mortality><multidisciplinary><novel><public health relevance><recruit><skills><social role><systematic review><tool><transition from adolescence to adulthood><transition into adulthood><transition to adulthood><twenty-one year old><twenty-one years of age><validations><vulnerable adolescent><youngster>
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Naomi Vanessa Ekas

TEXAS CHRISTIAN UNIVERSITY, FORT WORTH, TX

Exploratory lead · 20/100
Solid budget
Active award
$391,233
FY 2024

Project Title

The Role of Family Contextual Factors in the Development of Emotion Regulation in Young Children on the Autism Spectrum

Grant Number:

1R15HD111877-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT The majority of children on the autism spectrum have a co-occurring mental health disorder and emotion dysregulation is posited to serve as a risk factor for the development of mental health disorders. However, regulating emotions is a dynamic process that is influenced by t...

Research Terms

<0-11 years old><ASD><Academic Research Enhancement Awards><Anger><Application Context><Autism><Autism diagnostic><Autistic Disorder><Behavioral><Characteristics><Child><Child Development><Child Rearing><Child Youth><Children (0-21)><Climate><Data><Development><Early Infantile Autism><Emotional><Emotions><Environment><Family><Fathers><Fear><Fright><Geographic Area><Geographic Locations><Geographic Region><Geographical Location><Goals><Happiness><Health><Heterogeneity><Infant and Child Development><Infantile Autism><Intervention><Intervention Strategies><Investigation><Kanner's Syndrome><Knowledge><Language><Longitudinal Studies><Measures><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Meteorological Climate><Methods><Modeling><Mothers><NICHD><NIH><National Institute of Child Health and Human Development><National Institute of Children's Health and Human Development><National Institutes of Health><Outcome><Parenting><Parenting behavior><Parents><Pathway interactions><Physiologic><Physiological><Process><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Public Health><Publishing><R15 Mechanism><R15 Program><Reaction><Reporting><Research><Research Activity><Risk><Risk Factors><Role><Sampling><Severities><Specific qualifier value><Specified><Students><Survey Method><Survey Methodology><Testing><Texas><United States National Institutes of Health><Universities><Work><angers><angry><autism attributes><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic children><autistic features><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><career><childrearing><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><climatic><comparator group><comparison group><contextual factors><design><designing><developmental><emotion dysregulation><emotion regulation><emotional dysregulation><emotional regulation><experience><geographic site><innovate><innovation><innovative><interventional strategy><kids><long-term study><longitudinal outcome studies><longterm study><mental development><mental illness><parent><pathway><premature><prematurity><prevent><preventing><psychiatric illness><psychological disorder><public health priorities><recruit><skills><social role><theories><youngster>
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Melissa Borgen

FLORIDA INSTITUTE OF TECHNOLOGY, MELBOURNE, FL

Exploratory lead · 20/100
Solid budget
Active award
$389,851
FY 2024

Project Title

The role of PHR signaling in tauopathy-related neurodegeneration

Grant Number:

1R15NS137207-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/17/2024

End Date:

8/31/2027

Project Abstract

Project Summary Neurodegenerative diseases cause a progressive loss of neuronal function. Currently, an estimated 6 million Americans are live with dementia. Diagnosis often happens after symptoms start and irreversible damage has already occurred. Patients face a bleak prognosis, as treatments are ...

Research Terms

<Academic Research Enhancement Awards><Address><Affect><Alleles><Allelomorphs><Alzheimer beta-Protein><Alzheimer's Amyloid beta-Protein><Alzheimer's amyloid><Amentia><American><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Animal Model><Animal Models and Related Studies><Animals><Antibody Therapy><Area><Axon><Aβ><Binding><Biological Markers><Biomedical Research><C elegans><C. elegans><C.elegans><Caenorhabditis elegans><Cell Communication and Signaling><Cell Signaling><Cessation of life><DNA Molecular Biology><Data><Death><Degenerative Neurologic Disorders><Dementia><Development><Diagnosis><Diagnostic><Disease><Disease Progression><Disorder><Drug Targeting><Drugs><E3 Ligase><E3 Ubiquitin Ligase><Early Diagnosis><Event><Face><Florida><Future><Genes><Genetic><Genetic Alteration><Genetic Change><Genetic analyses><Genetic defect><Growth Cones><Human><Injury><Intracellular Communication and Signaling><Label><Life><Link><Literature><MT-bound tau><Maintenance><Medication><Micro-tubule><Microtubules><Mitochondria><Modeling><Modern Man><Molecular><Molecular Biology><Molecular Interaction><Morphology><Mutation><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural Development><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><Neurons><Neurosciences Research><Optics><Ortholog><Orthologous Gene><Pathway interactions><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pharmaceutical Preparations><Play><Process><Prognosis><Proteins><Publishing><R15 Mechanism><R15 Program><Regulation><Research><Research Infrastructure><Role><Severities><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Students><Symptoms><Synapses><Synaptic><Tauopathies><Technology><Time><Transgenic Organisms><Ubiquitilation><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Ubiquitination><Ubiquitinoylation><Work><a beta peptide><abeta><amyloid beta><amyloid-b protein><antibody based therapies><antibody treatment><antibody-based therapeutics><antibody-based treatment><axon damage><axon injury><axonal damage><axonal degeneration><axonal injury><beta amyloid fibril><bio-markers><biologic marker><biological signal transduction><biomarker><biomarker identification><degenerative axon><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><density><developmental><disease model><disorder model><drug development><drug/agent><early detection><faces><facial><fluorescence imaging><fluorescent imaging><genetic analysis><genetic approach><genetic strategy><genome mutation><identification of biomarkers><identification of new biomarkers><improved><in vivo><ineffective therapies><ineffective treatment><injuries><innovate><innovation><innovative><insight><insoluble aggregate><interest><life span><lifespan><marker identification><microtubule bound tau><microtubule-bound tau><mitochondrial><model of animal><mouse model><murine model><nerve cell death><nerve cell loss><nervous system development><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurodegenerative phenotype><neurodevelopment><neurological degeneration><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal><neuronal cell death><neuronal cell loss><neuronal death><neuronal degeneration><neuronal loss><neuropathologic tau><neuropathological tau><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><optical><p-tau><p-τ><pathway><patient oriented outcomes><phospho-tau><phospho-τ><phosphorylated tau><post-translational modification of tau><posttranslational modification of tau><protein aggregate><protein aggregation><social role><soluble amyloid precursor protein><synapse><synapse formation><synaptogenesis><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau factor><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau phosphorylation><tau posttranslational modification><tau-1><tauopathic neurodegenerative disorder><tauopathy><therapeutic outcome><therapy outcome><timeline><transgenic><ubiquination><ubiquitin conjugation><ubiquitin-protein ligase><undergrad><undergraduate><undergraduate student><τ Proteins><τ phosphorylation>
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SERGUEI N SKATCHKOV

UNIVERSIDAD CENTRAL DEL CARIBE, BAYAMON, PR

Exploratory lead · 20/100
Solid budget
Active award
$389,424
FY 2024

Project Title

Glial Cells and Polyamine Signaling in the Central Nervous System

Grant Number:

2R15NS116478-02

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2021

End Date:

7/31/2027

Project Abstract

Recent emergent interest and progress in studying polyamines (PAs) demonstrate that PAs are key players in Alzheimer’s, Huntington’s and Parkinson diseases and several syndromes as well as in aging and HIV associated neurocognitive disorder (HAND). PAs are released in whole brain from internal sourc...

Research Terms

<21+ years old><4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><AD dementia><AIDS Virus><AMPA Receptors><ATP13A2><Acetylation><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Acquired brain injury><Address><Adult><Adult Human><Affect><Affinity><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Amentia><Aminalon><Aminalone><Ammon Horn><Apoplexy><Area><Astrocytes><Astrocytus><Astroglia><Autoregulation><Biological Markers><Biosensor><Biotinylation><Blood><Blood Reticuloendothelial System><Blood Vessels><Brain><Brain Diseases><Brain Disorders><Brain Injuries><Brain Ischemia><Brain Nervous System><Brain Vascular Accident><CNS Diseases><CNS Nervous System><CNS disorder><Cell Communication and Signaling><Cell Signaling><Central Nervous System><Central Nervous System Diseases><Central Nervous System Disorders><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communicating Junction><Connector Neuron><Connexin 43><Connexin43><Cornu Ammonis><Cx43><Data><Dementia><Disease><Disorder><Disturbance in cognition><Encephalon><Encephalon Diseases><Environment><Epilepsy><Epileptic Seizures><Epileptics><Foundations><Funding><Future><GABA><Gap Junctions><Giant Cells><Glia><Glial Cells><Goals><HIV><HIV 1 associated neurocognitive disorder><HIV associated neurocognitive deficit><HIV associated neurocognitive impairment><HIV induced neurocognitive deficit><HIV induced neurocognitive impairment><HIV neurocognitive impairment><HIV-1 associated neurocognitive deficit><HIV-1 associated neurocognitive disorder><HIV-1 associated neurocognitive impairment><HIV-associated neurocognitive disorder><Hippocampus><Homeostasis><Human><Human Immunodeficiency Viruses><Huntington Chorea><Huntington Disease><Huntington's><Huntington's Disease><Huntingtons Disease><Immunoblotting><Impaired cognition><Increase lifespan><Individual><Intercalary Neuron><Intercalated Neurons><Interneuron function><Interneurons><Internuncial Cell><Internuncial Neuron><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Ischemia><Ischemic Encephalopathy><K channel><Knowledge><Kolliker's reticulum><Kufor-Rakeb syndrome gene><LAV-HTLV-III><Length of Life><Literature><Longevity><Low-resistance Junction><Lymphadenopathy-Associated Virus><Lymphatic cell><Lymphocyte><Lymphocytic><Measures><Mental disorders><Mental health disorders><Modern Man><Morbidity><Morbidity - disease rate><Multinucleated Giant Cells><Nerve Cells><Nerve Degeneration><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neuraxis><Neurocognitive Impairment in HIV><Neurocognitive Impairment in HIV-1><Neurocyte><Neuroglia><Neuroglial Cells><Neurologic><Neurological><Neuron Degeneration><Neuronal Transmission><Neurons><Nexus Junction><Non-neuronal cell><Nonneuronal cell><PARK9><PARK9 gene><Paralysis Agitans><Parkinson><Parkinson Disease><Parkinson disease 9 gene><Patch-Clamp Technics><Patch-Clamp Techniques><Pathologic><Pathology><Pathway interactions><Physiologic><Physiological><Physiological Homeostasis><Physiology><Play><Polyamine Compound><Polyamines><Polykaryocytes><Potassium Channel><Potassium Ion Channels><Primary Parkinsonism><Primary Senile Degenerative Dementia><Process><Psychiatric Disease><Psychiatric Disorder><Public Health><Publishing><RNA Binding><RNA bound><Receptor Protein><Research><Retina><Risk><Role><Scheme><Seizure Disorder><Short interfering RNA><Signal Transduction><Signal Transduction Systems><Signaling><Small Interfering RNA><Source><Spermidine><Spermine><Stroke><Synapses><Synaptic><Syncytium><Syndrome><Therapeutic><Transmission><Trauma><Tzanck Cell><Viral><Virus-HIV><Visualization><Western Blotting><Western Immunoblotting><Work><adulthood><astrocytic glia><axon signaling><axon-glial signaling><axonal signaling><bio-markers><biologic marker><biological sensor><biological signal transduction><biomarker><brain attack><brain damage><brain-injured><cerebral vascular accident><cerebrovascular accident><cognitive dysfunction><cognitive loss><dietary><elongating the lifespan><epilepsia><epileptogenic><extend life span><extend lifespan><extracellular><gamma-Aminobutyric Acid><gap junction channel><glia signaling><glial activation><glial cell activation><glial signaling><graduate student><hippocampal><immunocytochemistry><interest><knock-down><knockdown><lifespan extension><lymph cell><mental illness><mortality><nerve cement><nerve signaling><neural degeneration><neural signaling><neurocognitive disorder><neurodegeneration><neurodegenerative><neurological degeneration><neuron toxicity><neuronal><neuronal degeneration><neuronal signaling><neuronal toxicity><neuroprotection><neuroprotective><neurotoxicity><neurotransmission><novel><pathway><postsynaptic><primary degenerative dementia><protein blotting><psychiatric illness><psychological disorder><receptor><response><senile dementia of the Alzheimer type><sensor><siRNA><social role><stroked><strokes><synapse><tool><transmission process><uptake><vascular><γ-Aminobutyric Acid>
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Damian Alexander Stanley

ADELPHI UNIVERSITY, GARDEN CITY, NY

Exploratory lead · 20/100
Solid budget
Active award
$388,026
FY 2025

Project Title

Identifying social computational phenotypes in mental health

Grant Number:

1R15MH138992-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/9/2024

End Date:

12/8/2027

Project Abstract

PROJECT SUMMARY The ability to learn about other people and make social decisions is critical for successfully navigating our complex social environment and the consequences of failure can be severe (e.g., loss of employment, damage to relationships, etc.). Impairment in the social processes that su...

Research Terms

<2-dimensional><21+ years old><Academic Research Enhancement Awards><Adult><Adult Human><Age><Behavior><Behavioral><Brain><Brain Nervous System><Causality><Characteristics><Clinical><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Complex><Corpus Striatum><Corpus striatum structure><Data><Data Analyses><Data Analysis><Decision Making><Development><Diagnostic><Dimensions><Disease><Disorder><Disturbance in cognition><Dysfunction><Employment><Encephalon><Etiology><Experimental Designs><Failure><Feedback><Foundations><Functional MRI><Functional Magnetic Resonance Imaging><Functional disorder><Funding><General Taxonomy><Goals><Impaired cognition><Impairment><Individual Differences><Interdisciplinary Research><Interdisciplinary Study><Laboratories><Learning><Maps><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Methods><Mind><Modeling><Multidisciplinary Collaboration><Multidisciplinary Research><NIMH><National Institute of Mental Health><Neurocognitive><Neurosciences><Parietal Lobe><Participant><Persons><Phenotype><Physiopathology><Population><Process><Psychiatric Disease><Psychiatric Disorder><Psychiatry><Psychological Health><Psychology><Psychopathology><R15 Mechanism><R15 Program><RDoC><Research><Research Domain Criteria><Rewards><Sampling><Social Environment><Social Processes><Strategic Planning><Striate Body><Striatum><Students><Survey Instrument><Surveys><System><Taxonomy><Techniques><Training><Universities><Update><Variant><Variation><Work><abnormal psychology><adulthood><ages><behavior prediction><behavior study><behavior test><behavioral prediction><behavioral study><behavioral test><career><causation><cognitive dysfunction><cognitive loss><cognitive process><computer science><data interpretation><design><designing><developmental><digital assessment><disease causation><experiment><experimental research><experimental study><experiments><fMRI><individual heterogeneity><individual variability><individual variation><innovate><innovation><innovative><insight><interest><large scale data><large scale data sets><large scale datasets><mental illness><model design><neural><neural correlate><neural imaging><neuro-imaging><neuroimaging><neurological imaging><novel><parietal cortex><pathophysiology><programs><psychiatric illness><psychologic><psychological><psychological disorder><simulation><skills><social><social climate><social context><social learning><socioenvironment><socioenvironmental><striatal><success><theory of mind><trait><two-dimensional><undergrad><undergraduate><undergraduate student>
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Lisa Kenyon

GRAND VALLEY STATE UNIVERSITY, ALLENDALE, MI

Exploratory lead · 20/100
Solid budget
Active award
$387,263
FY 2024

Project Title

Em-power: Maximizing Functional Independence for Children with Severe Cerebral Palsy

Grant Number:

1R15HD115230-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2027

Project Abstract

Abstract Nearly 30% of children with cerebral palsy (CP) will have severe CP and will be unable to functionally walk or self-propel a manual wheelchair. For these children, a powered wheelchair (PWC) provides their only option for functional mobility and independence. PWCs have been shown to provide...

Research Terms

<0-11 years old><AAC Device><AAC Intervention><Academic Research Enhancement Awards><Active Follow-up><Age><Augmentative and Alternative Communication><Automobile Driving><Care Givers><Caregivers><Cerebral Palsy><Child><Child Support><Child Youth><Children (0-21)><Classification><Climacteric><Communication><Control Groups><Custom><Education for Intervention><Educational Intervention><Electric wheelchair><Exclusion><Exhibits><Funding><Health><Health Care Professional><Health Professional><Healthcare professional><Instruction Intervention><International><Intervention><Intervention Strategies><Joystick><Learning><Manual wheelchair><Measures><Mechanical Wheelchairs><NIH><National Institutes of Health><Nonpowered Wheelchairs><Occupational><Outcome><Parents><Perception><Performance><Phase><Powered wheelchair><Pre-Post Tests><R15 Mechanism><R15 Program><Random Allocation><Random Selection><Randomized, Controlled Trials><Research><SBIR><Safety><Single-Blind Study><Single-blind><Small Business Innovation Research><Small Business Innovation Research Grant><Standardization><System><Systematics><Testing><Time><Training><Training Activity><Training Intervention><United States National Institutes of Health><Universities><Waiting Lists><Walking><Wheel Chairs><Wheelchairs><Work><active followup><ages><arm><clinical significance><clinically significant><communication device><customs><design><designing><disability><driving><empowerment><evidence base><follow up><follow up assessment><follow-up><followed up><followup><followup assessment><functional independence><improved><innovate><innovation><innovative><instructional intervention><interventional strategy><kids><life change><mobility aid><mobility device><parent><performance based assessments><performance based measurement><performance based measures><post intervention><professional students><randomized control trial><routine care><skills><skills training><tool><training module><undergrad><undergraduate><undergraduate student><waitlist><youngster>
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Comfort Z. Olorunsaiye

ARCADIA UNIVERSITY, GLENSIDE, PA

Exploratory lead · 20/100
Solid budget
Active award
$385,936
FY 2024

Project Title

Developing and testing a measure of sociocultural norms related to interpregnancy intervals in African immigrants in the US.

Grant Number:

1R15HD116088-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/20/2024

End Date:

8/31/2027

Project Abstract

PROJECT SUMMARY Despite the existence of guidelines from the World Health Organization and the American College of Obstetricians and Gynecologists recommending an optimal interpregnancy interval (IPI) of at least 18 to 24 months, nearly one-third of non-first births in the US are conceived within 18...

Research Terms

<ACOG><Address><Admission><Admission activity><Africa South of the Sahara><African><Age><American College of Obstetricians and Gynecologists><Behavior><Belief><Birth><Birth Intervals><Birth Spacing><Black><Black race><Caucasian Females><Caucasian Women><Communities><Contraception Behavior><Contraceptive Behavior><Contraceptive Usage><Country><Course Content><Data Collection><Demographic Factors><Development><Education><Educational aspects><Environment><Factor Analyses><Factor Analysis><Family><Family Planning><Family Planning Services><Fecundability><Fecundity><Feedback><Fertility><Future><Gestation><Ghana><Goals><Gold Coast><Grant><Guidelines><Healthcare><Home><Immigrant><Immigrant community><Immigration><Individual><Infant Mortality><Infant Mortality Total><Intervention><Intervention Strategies><Interview><Liberia><Low Birth Weight Infant><Maternal Mortality><Measurement><Measures><Mentors><Methods><Modeling><Modification><Neonatal Intensive Care Units><Newborn Intensive Care Units><Nigeria><Outcome><Paper><Parturition><Perception><Persons><Phase><Philadelphia><Population><Pregnancy><Premature Birth><Prematurely delivering><Preterm Birth><Property><Psychometrics><Publications><Qualitative Methods><Recommendation><Reproductive Health><Research><Risk Factors><Sampling><Science><Scientific Publication><Shapes><Sierra Leone><Small for Gestational Age Infant><Social support><Structure><Students><Sub-Saharan Africa><Subsaharan Africa><Testing><Universities><Uterine Rupture><Validation><Vulnerable Populations><White Females><White Women><Woman><World Health Organization><abortion><adverse consequence><adverse maternal outcomes><adverse outcome><aged><ages><care seeking><career development><clinical relevance><clinically relevant><cognitive assessment><cognitive testing><community based organizations><community engaged participatory research><community engaged research><community organizations><community partnered research><community-engaged study><community-partnered study><comparing females and males><comparing women and men><congenital anomaly><contraceptive practice><contraceptive use><course curriculum><culturally adapted intervention><culturally appropriate intervention><culturally centered intervention><culturally focused intervention><culturally informed intervention><culturally responsive intervention><culturally tailored intervention><death among infants><death in first year of life><death in infancy><death in infants><design><designing><developmental><experience><family influence><females compared to males><females compared with males><females versus males><females vs males><field based data><field learning><field study><field test><hands on research><health belief><health care><health disparity community><health disparity group><health disparity populations><health-related belief><high risk><homes><improved><infant death><infant demise><infant outcome><infantile death><interest><interventional strategy><knowledge base><low birth weight><low birthweight><maternal death><men><mortality in infants><neonatal ICU><novel><post-partum contraception><post-partum contraceptive><postpartum contraception><postpartum contraceptive><premature childbirth><premature delivery><preterm delivery><programs><qualitative reasoning><rapid growth><reproductive><small for gestational age><social><social cultural factor><social culture><social culture determinant><social factors><social norm><social stigma><social support network><socio-cultural><sociocultural><sociocultural determinant><sociocultural factor><stigma><tool><validations><vulnerable group><vulnerable individual><vulnerable people><women compared to men><women compared with men><women versus men><women vs men>
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Erik Benjamin Oleson

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 20/100
Solid budget
Active award
$385,638
FY 2025

Project Title

Cannabinoid Tolerance Across Neurodevelopment: Disruption of Value-Driven Behavior and Prevention Through Physical Activity

Grant Number:

1R15DA063975-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2025

End Date:

8/31/2028

Project Abstract

Project Summary An illicit drug enterprise is currently duping United States citizens by marketing synthetic cannabinoids to them as a safe alternative to cannabis. Professionals and students are also drawn to these compounds to cheat conventional drug tests. Rather than a safe alternative, most syn...

Research Terms

<21+ years old><9-ene-Tetrahydrocannabinol><Academic Research Enhancement Awards><Adaptive Behaviors><Adolescent><Adolescent Youth><Adult><Adult Human><Adult females><Adult women><Adverse Experience><Adverse event><Affect><Age><Authorship><Awareness><Behavior><Behavioral><Brain><Brain Nervous System><Cannabinoids><Cannabis><Cell Communication and Signaling><Cell Signaling><Chemicals><Chronic><Circulatory Collapse><Collaborations><Common Rat Strains><Cues><Cyclicity><D9-tetrahydrocannabinol><DA Neuron><Dangerousness><Data><Data Analyses><Data Analysis><Data Collection><Delta-9-Tetrahydrocannabinol><Detection><Development><Dopamine><Dopamine neuron><Drugs><Elderly><Encephalon><Event><Exercise><Exposure to><Female><Females in adulthood><Fostering><Gender><Goals><Harm Minimization><Harm Reduction><History><Hydroxytyramine><Illicit Drugs><Impairment><Individual><Intracellular Communication and Signaling><Investigation><Journals><Literature><Magazine><Marketing><Medication><Modeling><NIDA><National Institute of Drug Abuse><National Institute on Drug Abuse><Nature><Neural Development><Neurobiology><Neurosciences><Outcome><Periodicity><Pharmaceutical Preparations><Pharmacology><Physical activity><Population><Predictive Value><Preparation><Prevention><Price><Public Health><Publishing><R15 Mechanism><R15 Program><Rat><Rats Mammals><Rattus><Receptor Activation><Receptor Protein><Recording of previous events><Research><Rewards><Rhythmicity><Risk><Running><Scanning><Shock><Signal Transduction><Signal Transduction Systems><Signaling><Societies><Stress><Students><Testing><Tetrahydrocannabinol><Time><United States><Women in adulthood><Work><abused drug><abused drugs><adaptation behavior><adaptive behavior><addiction><addictive disorder><adulthood><advanced age><advanced age rats><aged rat><aged rats><ages><behavioral economics><biological signal transduction><cannabinoid receptor><circulatory shock><data interpretation><delta(1)-THC><delta(1)-Tetrahydrocannabinol><delta(9)-THC><delta(9)-Tetrahydrocannabinol><design><designing><developmental><disparities in race><disparity due to race><dopaminergic neuron><drug abused><drug detection><drug of abuse><drug standard><drug testing><drug/agent><drugs abused><drugs of abuse><elderly rats><foot><geriatric><geriatric rats><histories><improved><inequality due to race><inequity due to race><innovate><innovation><innovative><insight><juvenile><juvenile human><life span><lifespan><male><meeting><meetings><neurobehavioral><neurobiological><neurochemical><neurochemistry><neurodevelopment><new drug class><novel><novel drug class><old age><old rats><pharmacologic><positive mood><posters><preparations><pricing><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial disparity><racial inequality><racial inequity><racially unequal><receptor><resilience><resilient><senior citizen><sex><shocks><sugar><synthetic cannabinoid><tool><undergrad><undergraduate><undergraduate student><Δ(1)-THC><Δ(1)-tetrahydrocannabinol><Δ(9)-THC><Δ(9)-tetrahydrocannabinol><Δ-9-tetrahydrocannabinol><Δ9-tetrahydrocannabinol><♀><♂>
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ANGELA J GRIPPO

NORTHERN ILLINOIS UNIVERSITY, DE KALB, IL

Exploratory lead · 20/100
Solid budget
Active award
$380,000
FY 2025

Project Title

Promoting resilience and mechanisms underlying emotion and cardiovascular health as a function of adolescent social stress

Grant Number:

1R15HL179691-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2025

End Date:

8/31/2028

Project Abstract

This R15 project will investigate mechanisms of emotion, stress, and health, with a specific focus on mechanisms underlying treatments for adolescent social stress. Social isolation and loneliness during adolescence significantly reduce quality of life and contribute to adulthood heart disease and m...

Research Terms

<12-20 years old><21+ years old><Adolescence><Adolescent><Adolescent Development><Adolescent Youth><Adult><Adult Human><Affective Disorders><Animal Model><Animal Models and Related Studies><Animals><Anxiety><Behavior><Behavioral><Brain><Brain Nervous System><Brain Stem><Brain region><Brainstem><Cardiac><Cardiac Chronotropism><Cardiac Diseases><Cardiac Disorders><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Cognition><Communication><Data Collection><Development><Emotional><Emotions><Encephalon><Endocrine><Endocrine Gland Secretion><Environment><Exhibits><Family><Foundations><Goals><Health><Heart Diseases><Heart Rate><Heart Vascular><Hormones><Human><Illinois><Knowledge><Loneliness><Measurement><Measures><Mediating><Mental Depression><Mental Health><Mental Hygiene><Modeling><Modern Man><Mood Disorders><Neurobiology><Neuroendocrine><Neuroendocrine System><Neuropeptides><Neurosecretory Systems><Ocytocin><Outcome><Oxytocin><Paraventricular Hypothalamic Nucleus><Physiologic><Physiological><Psychological Health><QOL><Quality of life><Recombinant Oxytocin><Research><Research Design><Research Training><Risk><Rodent><Rodent Model><Rodentia><Rodents Mammals><Sensory><Social Behavior><Social Environment><Social Interaction><Social Well-Being><Social isolation><Socialization><Stress><Stress and Coping><Students><Study Type><Tactile><Testing><Therapeutic Hormone><Translating><Universities><Writing><adolescence (12-20)><adulthood><behavior outcome><behavior response><behavioral outcome><behavioral response><biological adaptation to stress><build resilience><build resiliency><cardiac rhythm><cardiovascular disorder><cardiovascular health><circulatory system><coping mechanism><coping with stress><depression><develop resilience><develop resiliency><developmental><emotion dysregulation><emotional dysregulation><enhance resilience><enhance resiliency><environment enrichment><environment enrichment for laboratory animals><environmental enrichment><environmental enrichment for laboratory animals><facilitate resilience><heart disorder><heart rate variability><heart rhythm><immunoreactivity><improve resilience><improve resiliency><improved><increase resilience><increase resiliency><information processing><juvenile><juvenile human><life span><lifespan><lonely><model of animal><neural mechanism><neurobiological><neuromechanism><pandemic><pandemic disease><paraventricular nucleus><physical conditioning><physical health><prairie vole><prevent><preventing><promote resilience><promote resiliency><protective effect><reactioncrisis><resilience development><resilient to stress><response><social><social attachment><social bonding><social climate><social context><social stress><social stresses><social stressor><social structural><social structure><social wellbeing><socially stressed><socio-structural><sociobehavior><sociobehavioral><socioenvironment><socioenvironmental><sociostructural><stress reactivity><stress related disorder><stress resilience><stress resiliency><stress response><stress-related coping><stressreaction><stressor><student training><study design><success><timeline><tool><treatment effect><treatment strategy><undergrad><undergraduate><undergraduate education><undergraduate student>
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Kate Brody Nooner

UNIVERSITY OF NORTH CAROLINA WILMINGTON, WILMINGTON, NC

Exploratory lead · 20/100
Solid budget
Active award
$379,503
FY 2022

Project Title

Biomarkers of Binge Drinking in Maltreated Adolescents

Grant Number:

1R15AA028911-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/20/2022

End Date:

8/31/2026

Project Abstract

PROJECT SUMMARY In the current R15 application, we propose a critical continuation of a home-based, longitudinal study aimed at identifying neurodevelopmental pathways associated with risk and resilience to heavy episodic drinking (HED; i.e., binge drinking) in maltreated adolescents compared to mat...

Research Terms

<0-11 years old><12-20 years old><14 year old><14 years of age><19 year old><19 years of age><21+ years old><Academic Research Enhancement Awards><Adolescence><Adolescent><Adolescent Youth><Adult><Adult Human><Affective><Age><Alcohol Drinking><Alcohol consumption><Behavior><Behavioral><Biological Markers><Brain><Brain Nervous System><Caring><Child><Child Abuse and Neglect><Child Youth><Childhood><Childhood maltreatment><Children (0-21)><Clinical><Cognitive><Communities><Data><Development><Diagnostic><EEG><Electroencephalogram><Electroencephalography><Encephalon><EtOH drinking><EtOH use><Ethnic Origin><Ethnicity><Gender><Heavy Drinking><Home><Institution><Intervention><Intervention Strategies><Left><Link><Longitudinal Studies><Measures><Mental disorders><Mental health disorders><Neighborhoods><Neurosciences><North Carolina><Parietal><Participant><Pathway interactions><Pattern><Peer Review><Ph D student><Ph D. student><Ph. D. student><Ph.D student><Ph.D. student><PhD student><PhD. student><Phase><Phenotype><Prevention><Problem behavior><Psychiatric Disease><Psychiatric Disorder><Publications><R15 Mechanism><R15 Program><Research><Rest><Risk><Risk Marker><Role><Sample Size><Sampling><Scientific Publication><Social Service><Social Work><Socio-economic status><Socioeconomic Status><Stress><Students><THC co-use><THC use><Tetrahydrocannabinol co-use><Tetrahydrocannabinol use><Time><Trauma><Universities><Unplanned pregnancy><Visit><Work><Youth><Youth 10-21><Youth Drinking><adolescence (12-20)><adolescent alcohol co-use><adolescent alcohol consumption><adolescent alcohol drinking><adolescent alcohol intake><adolescent alcohol use><adolescent drinking><adulthood><adverse consequence><adverse outcome><age 14 years><age 19 years><ages><alcohol during adolescence><alcohol ingestion><alcohol intake><alcohol intake among adolescents><alcohol product use><alcohol use><alcohol use among adolescents><alcohol use during adolescence><alcohol use in adolescence><alcohol use in adolescents><alcoholic beverage consumption><alcoholic drink intake><base><behavioral problem><binge alcohol consumption><binge drinking><bio-markers><biologic marker><biomarker><cannabis use><child maltreatment><cohort><conference><convention><cost><critical developmental period><developmental><doctoral student><drink heavily><drinking during adolescence><drinking in adolescent><episodic drinking><ethanol consumption><ethanol drinking><ethanol during adolescence><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><excessive alcohol consumption><excessive alcohol ingestion><excessive alcohol intake><excessive drinking><excessive ethanol ingestion><experience><extreme drinking><fourteen year old><fourteen years of age><graduate student><heavy alcohol use><high risk><high risk behavior><innovate><innovation><innovative><interventional strategy><juvenile><juvenile human><long-term study><longitudinal outcome studies><longterm study><maltreated children><maltreatment><marijuana use><mental illness><mistreatment><nineteen year old><nineteen years old><novel><pathway><pediatric><psychiatric illness><psychological disorder><recruit><resilience><response><social role><socio-economic position><socioeconomic position><substance use><substance using><summit><symposia><symposium><teen drinking><teenage alcohol use><teenage drinking><teenager alcohol use><trauma symptom><under age alcohol consumption><under age alcohol use><underage alcohol consumption><underage alcohol use><underage drinking><undergrad><undergraduate><undergraduate student><unintended pregnancy><youngster><youth alcohol co-use><youth alcohol consumption><youth alcohol use>
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LOYDA BEATRIZ MENDEZ

SISTEMA UNIVERSITARIO ANA G. MENDEZ, INCORPORADO, CAROLINA, PR

Exploratory lead · 20/100
Solid budget
Active award
$366,692
FY 2024

Project Title

Particle Pollution Impact on Prefrontal Cortex Function During Adolescence

Grant Number:

1R15ES035973-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2027

Project Abstract

This is an application for the Academic Research Enhancement Award (AREA) for Undergraduate-Focused Institutions to carry out a toxicological study to gain insights about the biological basis by which particle pollution can alter brain function during adolescence and its potential impact in mental h...

Research Terms

<0-11 years old><12-20 years old><Academic Research Enhancement Awards><Accounting><Address><Adolescence><Adolescent><Adolescent Development><Adolescent Youth><Adolescent and Young Adult><Affect><Age><Air Pollution><Animal Model><Animal Models and Related Studies><Astrocytes><Astrocytus><Astroglia><Attention><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Behavior><Behavior assessment><Behavioral><Biological><Biological Function><Biological Process><Brain><Brain Nervous System><C57BL/6 Mouse><CNS Nervous System><CTLA-8><CTLA-8 Gene><CTLA8><CTLA8 Gene><Central Nervous System><Cessation of life><Chemotactic Cytokines><Child><Child Youth><Childhood><Children (0-21)><Clinical><Cognitive><Cognitive Discrimination><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive deficits><Cognitive function abnormal><Cytotoxic T-Lymphocyte-Associated Antigen 8><Cytotoxic T-Lymphocyte-Associated Antigen 8 Gene><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 Gene><DALY><Data><Death><Development><Developmental Process><Diesel Exhaust><Discrimination><Disease><Disorder><Disturbance in cognition><Dose><Edodekin Alfa><Emotional><Encephalon><Environmental Factor><Environmental Health><Environmental Health Science><Environmental Risk Factor><Epidemiologic Research><Epidemiologic Studies><Epidemiological Studies><Epidemiology Research><Exploratory Behavior><Exposure to><Family><Female><Generalized Growth><Goals><Grant><Growth><HPGF><Health><Hepatocyte-Stimulating Factor><Hispanic><Homologous Chemotactic Cytokines><Hortega cell><Human Rights><Hybridoma Growth Factor><Hyperactivity><IFN-beta 2><IFNB2><IL-1><IL-12><IL-17><IL-17 Gene><IL-17A><IL-17A Gene><IL-6><IL1><IL12><IL17><IL17 Protein><IL17 gene><IL17A><IL17A Gene><IL6 Protein><Immediate Memory><Impaired cognition><Impairment><Individual><Inflammation Mediators><Inflammatory><Inflammatory Response><Institution><Intercrines><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) Gene><Interleukin 17 Precursor><Interleukin 17 Precursor Gene><Interleukin I><Interleukin-1><Interleukin-12><Interleukin-17><Interleukin-6><Knowledge><Life><Locomotion><Low income><Lymphocyte-Stimulating Hormone><MGI-2><Macrophage Cell Factor><Measures><Mental disorders><Mental health disorders><Mice><Mice Mammals><Microglia><Molecular><Morphology><Murine><Mus><Myeloid Differentiation-Inducing Protein><NIEHS><NIH><NKSF><National Institute of Environmental Health Sciences><National Institutes of Health><Natural Killer Cell Stimulatory Factor><Neuraxis><Neurocognitive><Outcome><Particulate Matter><Personal Satisfaction><Phenotype><Plasmacytoma Growth Factor><Play><Pollution><Predisposition><Prefrontal Cortex><Prepuberal state><Prevalence><Principal Investigator><Problem Solving><Process><Psychiatric Disease><Psychiatric Disorder><Puberty><Public Health><R15 Mechanism><R15 Program><Research><Risk><Risk Factors><Risk Taking><Rodent Model><Role><SIS cytokines><Short-Term Memory><Shortterm Memory><Structure><Students><Susceptibility><T Helper Factor><Time><Tissue Growth><Toxicology><United States National Institutes of Health><adolescence (12-20)><ages><astrocytic glia><behavioral assessment><biologic><brain circuitry><burden of disease><burden of illness><chemoattractant cytokine><chemokine><clinical significance><clinically significant><cognitive defects><cognitive development><cognitive dysfunction><cognitive function><cognitive loss><cognitive process><cognitive task><cytokine><density><developmental><disability-adjusted life years><disease burden><emotion regulation><emotional behavior><emotional regulation><environmental risk><epidemiologic investigation><epidemiology study><executive control><executive function><flexibility><flexible><gitter cell><inflammation marker><inflammatory marker><inflammatory mediator><innovate><innovation><innovative><insight><interferon beta 2><juvenile><juvenile human><kids><life span><lifespan><long term memory><longterm memory><lymphocyte activating factor><male><mental illness><mesoglia><microglial cell><microgliocyte><model of animal><myelination><neural imaging><neural inflammation><neuro-imaging><neuroimaging><neuroinflammation><neuroinflammatory><neurological imaging><neuron toxicity><neuronal toxicity><neurotoxicity><ontogeny><ostracism><ostracize><particle><particle exposure><pediatric><peer exclusion><perivascular glial cell><post-natal development><postnatal><postnatal development><prepubertal><prepuberty><programs><psychiatric illness><psychological disorder><social exclusion><social role><social stigma><spatiotemporal><stigma><synaptic pruning><traffic-related air pollution><trait><undergrad><undergraduate><undergraduate student><well-being><wellbeing><working memory><youngster>
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Ann Perreau

AUGUSTANA COLLEGE, ROCK ISLAND, IL

Exploratory lead · 20/100
Solid budget
Active award
$361,276
FY 2023

Project Title

A Feasibility Study of a Novel, Fully Remote Counseling and Sound Therapy Program for Hyperacusis

Grant Number:

1R15DC020539-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2023

End Date:

4/30/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT In line with the funding goals of the National Institutes of Health and the R15 AREA program, this application proposes to investigate the feasibility of a remote counseling and sound therapy program for reducing reactions to hyperacusis. Hyperacusis is a hearing condition c...

Research Terms

<Access to Care><Address><Affect><American><Antidepressant Agent><Antidepressant Drugs><Antidepressants><Antidepressive Agents><Auditory Perception><Auditory system><Award><Client><Clinical><Clinical Management><Clinical Research><Clinical Study><Clinical Trials Design><Cognition Therapy><Cognitive Psychotherapy><Cognitive Therapy><Communication><Complement><Complement Proteins><Counseling><Data><Data Collection><Devices><Disease><Disorder><Education><Educational aspects><Effectiveness><Ensure><Environment><Equipment and supply inventories><Exercise><Exposure to><Feasibility Studies><Focus Groups><Funding><Future><Goals><Guidelines><Health Services Accessibility><Hearing><Heterogeneity><Hour><Hyperacusia><Hyperacusis><Individual><Instruction><Intervention><Intervention Strategies><Inventory><Investigators><Loudness><Loudness Perception><Loudness Perception Disturbances><Loudness Recruitment><Low income><Measures><Mental Health><Mental Hygiene><Monitor><Music><NIH><National Institutes of Health><Nature><Noise><Outcome Measure><Pain><Painful><Participant><Patients><Persons><Population><Program Effectiveness><Psychiatric therapeutic procedure><Psychoacoustics><Psychological Health><Publishing><Questionnaires><Randomized><Randomized Controlled Clinical Trials><Reaction><Recommendation><Relaxation><Reporting><Research><Research Personnel><Researchers><Rural><Science><Site><Students><Symptoms><Testing><Training><Treatment Effectiveness><Treatment Protocols><Treatment Regimen><Treatment Schedule><United States National Institutes of Health><Work><access to health services><access to services><access to treatment><accessibility to health services><anti-depressant agent><anti-depressant drugs><anti-depressants><anti-depressive agents><assess effectiveness><availability of services><care access><chemical reaction rate><cognitive behavior intervention><cognitive behavior modification><cognitive behavior therapy><cognitive behavioral intervention><cognitive behavioral modification><cognitive behavioral therapy><cognitive behavioral treatment><college><collegiate><compare effectiveness><decreased loudness tolerance><delivered remotely><design><designing><determine effectiveness><effectiveness assessment><effectiveness evaluation><evaluate effectiveness><evidence base><examine effectiveness><experience><health service access><health services availability><hearing perception><improved><innovate><innovation><innovative><interventional strategy><loudness intolerance><measurable outcome><noise sensitivity><novel><outcome measurement><participant engagement><patient centered><patient engagement><patient oriented><patient population><programs><psychiatric care><psychiatric therapy><psychiatric treatment><randomisation><randomization><randomized control clinical trial><randomized, clinical trials><randomly assigned><reaction rate><remote administration><remote coaching><remote counseling><remote delivery><research study><response><service availability><sound><sound perception><success><telecoaching><telecounseling><treatment access><treatment effect><treatment program><undergrad><undergraduate><undergraduate research><undergraduate student>
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Marie-Claude Couture

UNIVERSITY OF SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 20/100
Solid budget
Active award
$359,419
FY 2022

Project Title

Determining the causal pathways of social and environmental predictors of high-risk alcohol drinking among college students

Grant Number:

1R15AA029256-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/15/2022

End Date:

7/31/2026

Project Abstract

The purpose of this R15 application is to characterize the broader environmental and social context leading to high-risk alcohol drinking in college populations. The proposed study will allow for a better understanding of the causal pathways between contextual environmental and social exposures and ...

Research Terms

<Address><Adolescent and Young Adult><Alcohol Chemical Class><Alcohol Drinking><Alcohol abuse><Alcohol consumption><Alcohols><Anxiety><Behavior><Cessation of life><Cognitive><Cognitive Discrimination><Complex><Crime><Data><Data Collection><Death><Development><Discrimination><Disease><Disorder><Ecological momentary assessment><Emotional><Environment><Equation><EtOH abuse><EtOH drinking><EtOH use><Ethnic Origin><Ethnicity><Fear><Fright><Gender><Geography><Goals><Health><Heavy Drinking><Intervention><Intervention Strategies><Knowledge><Lead><Mediation><Mediator><Mediator of Activation><Mediator of activation protein><Mental Depression><Methods><Modeling><Negotiating><Negotiation><Outcome><PTSD><Pathway interactions><Pb element><Population><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Posttraumatic Neuroses><Posttraumatic Stress Disorders><Problem Solving><Psychosocial Factor><R-Series Research Projects><R01 Mechanism><R01 Program><Race><Racial Group><Racial Stocks><Reporting><Research><Research Design><Research Grants><Research Infrastructure><Research Project Grants><Research Projects><Research Training><Social Environment><Students><Study Type><Techniques><Time><University drinking><Victimization><Violence><Youth Drinking><adolescent alcohol co-use><adolescent alcohol consumption><adolescent alcohol drinking><adolescent alcohol intake><adolescent alcohol use><adolescent drinking><alcohol co-abuse><alcohol during adolescence><alcohol ingestion><alcohol intake><alcohol intake among adolescents><alcohol outlet density><alcohol problem><alcohol product use><alcohol risk><alcohol use><alcohol use among adolescents><alcohol use during adolescence><alcohol use in adolescence><alcohol use in adolescents><alcohol use in college students><alcoholic beverage consumption><alcoholic drink intake><base><binge alcohol consumption><binge drinking><bully><bullying><campus drinking><college><college drinking><college student><college student drinking><collegiate><collegiate drinking><depression><developmental><drink heavily><drinking behavior><drinking during adolescence><drinking in adolescent><effective intervention><episodic drinking><ethanol abuse><ethanol consumption><ethanol drinking><ethanol during adolescence><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><ethnic difference><ethnicity difference><ethnoracial><excessive alcohol consumption><excessive alcohol ingestion><excessive alcohol intake><excessive drinking><excessive ethanol ingestion><experience><extreme drinking><gender difference><gender-associated difference><hazardous alcohol use><heavy alcohol use><heavy metal Pb><heavy metal lead><high risk><innovate><innovation><innovative><interventional strategy><methods to study multiple-level influences><multi-level analysis><multi-level model><multilevel analysis><multilevel model><multilevel modeling><novel><pathway><post-trauma stress disorder><posttrauma stress disorder><problem alcohol use><problem drinking><problematic alcohol consumption><problematic alcohol use><psychosocial variables><racial and ethnic><social><social climate><social context><social defects><social deficits><social disorders><social dysfunction><socioenvironment><socioenvironmental><study design><substance use><substance using><teen drinking><teenage alcohol use><teenage drinking><teenager alcohol use><theories><training opportunity><traumatic neurosis><under age alcohol consumption><under age alcohol use><underage alcohol consumption><underage alcohol use><underage drinking><university student><university student drinking><violent><violent behavior><youth alcohol co-use><youth alcohol consumption><youth alcohol use>
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Erin Grinshteyn

UNIVERSITY OF SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 20/100
Solid budget
Active award
$359,419
FY 2022

Project Title

Determining the causal pathways of social and environmental predictors of high-risk alcohol drinking among college students

Grant Number:

1R15AA029256-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/15/2022

End Date:

7/31/2026

Project Abstract

The purpose of this R15 application is to characterize the broader environmental and social context leading to high-risk alcohol drinking in college populations. The proposed study will allow for a better understanding of the causal pathways between contextual environmental and social exposures and ...

Research Terms

<Address><Adolescent and Young Adult><Alcohol Chemical Class><Alcohol Drinking><Alcohol abuse><Alcohol consumption><Alcohols><Anxiety><Behavior><Cessation of life><Cognitive><Cognitive Discrimination><Complex><Crime><Data><Data Collection><Death><Development><Discrimination><Disease><Disorder><Ecological momentary assessment><Emotional><Environment><Equation><EtOH abuse><EtOH drinking><EtOH use><Ethnic Origin><Ethnicity><Fear><Fright><Gender><Geography><Goals><Health><Heavy Drinking><Intervention><Intervention Strategies><Knowledge><Lead><Mediation><Mediator><Mediator of Activation><Mediator of activation protein><Mental Depression><Methods><Modeling><Negotiating><Negotiation><Outcome><PTSD><Pathway interactions><Pb element><Population><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Posttraumatic Neuroses><Posttraumatic Stress Disorders><Problem Solving><Psychosocial Factor><R-Series Research Projects><R01 Mechanism><R01 Program><Race><Racial Group><Racial Stocks><Reporting><Research><Research Design><Research Grants><Research Infrastructure><Research Project Grants><Research Projects><Research Training><Social Environment><Students><Study Type><Techniques><Time><University drinking><Victimization><Violence><Youth Drinking><adolescent alcohol co-use><adolescent alcohol consumption><adolescent alcohol drinking><adolescent alcohol intake><adolescent alcohol use><adolescent drinking><alcohol co-abuse><alcohol during adolescence><alcohol ingestion><alcohol intake><alcohol intake among adolescents><alcohol outlet density><alcohol problem><alcohol product use><alcohol risk><alcohol use><alcohol use among adolescents><alcohol use during adolescence><alcohol use in adolescence><alcohol use in adolescents><alcohol use in college students><alcoholic beverage consumption><alcoholic drink intake><base><binge alcohol consumption><binge drinking><bully><bullying><campus drinking><college><college drinking><college student><college student drinking><collegiate><collegiate drinking><depression><developmental><drink heavily><drinking behavior><drinking during adolescence><drinking in adolescent><effective intervention><episodic drinking><ethanol abuse><ethanol consumption><ethanol drinking><ethanol during adolescence><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><ethnic difference><ethnicity difference><ethnoracial><excessive alcohol consumption><excessive alcohol ingestion><excessive alcohol intake><excessive drinking><excessive ethanol ingestion><experience><extreme drinking><gender difference><gender-associated difference><hazardous alcohol use><heavy alcohol use><heavy metal Pb><heavy metal lead><high risk><innovate><innovation><innovative><interventional strategy><methods to study multiple-level influences><multi-level analysis><multi-level model><multilevel analysis><multilevel model><multilevel modeling><novel><pathway><post-trauma stress disorder><posttrauma stress disorder><problem alcohol use><problem drinking><problematic alcohol consumption><problematic alcohol use><psychosocial variables><racial and ethnic><social><social climate><social context><social defects><social deficits><social disorders><social dysfunction><socioenvironment><socioenvironmental><study design><substance use><substance using><teen drinking><teenage alcohol use><teenage drinking><teenager alcohol use><theories><training opportunity><traumatic neurosis><under age alcohol consumption><under age alcohol use><underage alcohol consumption><underage alcohol use><underage drinking><university student><university student drinking><violent><violent behavior><youth alcohol co-use><youth alcohol consumption><youth alcohol use>
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Nicholas Earl Burgis

EASTERN WASHINGTON UNIVERSITY, CHENEY, WA

Exploratory lead · 20/100
Solid budget
Active award
$354,861
FY 2024

Project Title

Computational and biochemical screening for the discovery of molecules that stabilize ITPA clinical variants

Grant Number:

2R15GM112121-02

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2015

End Date:

8/31/2027

Project Abstract

Project Summary/Abstract Human inosine triphosphate pyrophosphohydrolase (ITPA) is a protective enzyme that is essential for life. ITPA hydrolyzes inosine triphosphate (ITP) to the monophosphate form (IMP) to keep the nucleoside triphosphate from interfering with normal cellular processes and/or inc...

Research Terms

<1-Beta-D-ribofuranosyl-1,2,4-triazolo-3-carboxamide><1-Beta-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide><Address><Adopted><Affect><Affinity><Assay><Binding><Binding Sites><Bioassay><Biochemical><Biochemistry><Biological Assay><Biological Chemistry><Cancers><Catalysis><Cell Function><Cell Physiology><Cell Process><Cellular Function><Cellular Physiology><Cellular Process><Clinical><Collaborations><Combining Site><Complex><Computer Models><Computer Simulation><Computer based Simulation><Computerized Models><Data><Defect><Development><Disease><Disorder><Docking><Drugs><Effectiveness><Encephalopathies><Enzyme Gene><Enzyme Kinetics><Enzymes><Funding><Genetic Alteration><Genetic Change><Genetic defect><Goals><HPLC><Health><High Performance Liquid Chromatography><High Pressure Liquid Chromatography><High Speed Liquid Chromatography><High Throughput Assay><Human><ITP pyrophosphohydrolase><ITPase><Individual><Inosine><Investigators><Kinetics><Lead><Libraries><Life><Ligand Binding><Ligands><Lobe><Malignant Neoplasms><Malignant Tumor><Medication><Methods><Modern Man><Molecular><Molecular Dynamics Simulation><Molecular Interaction><Mutation><NIH><National Institutes of Health><Nucleic Acids><ODF factor><OPGL protein><Orphan Disease><Osteoclast Differentiation Factor><Osteoprotegerin Ligand><Outcome><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pb element><Personalized medical approach><Pharmaceutical Agent><Pharmaceutical Preparations><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Proteins><Publications><RANK ligand><Rare Diseases><Rare Disorder><Reaction><Reactive Site><Receptor Activator of Nuclear Factor Kappa B Ligand><Research><Research Personnel><Researchers><Resource Sharing><Ribavirin><Ribovirin><Role><Scientific Publication><Subcellular Process><TNF-Related Activation-Induced Cytokine><TRANCE protein><Testing><Tribavirin><Tumor Necrosis Factor Ligand Superfamily Member 11><United States National Institutes of Health><Universities><Variant><Variation><Washington><Work><alpha helix><chemical library><clinical relevance><clinically relevant><computational modeling><computational models><computational simulation><computer based models><computerized modeling><computerized simulation><design><designing><developmental><drug discovery><drug-like chemical><drug-like compound><drug-like molecule><drug/agent><enzyme activity><epileptic encephalopathies><experience><experiment><experimental research><experimental study><experiments><flexibility><flexible><genome mutation><heavy metal Pb><heavy metal lead><high throughput screening><in silico><individualized approach><infancy><infantile><innovate><innovation><innovative><inosine triphosphatase><inosine triphosphate pyrophosphohydrolase><insight><lobes><malignancy><molecular dynamics><mutant><neoplasm/cancer><nucleoside triphosphate><orphan disorder><patient oriented outcomes><personalized approach><pharmaceutical><precision approach><protein folding><screening><screenings><simulation><small molecule><small molecule libraries><social role><tailored approach><thiopurine><tool><triphosphate><tripolyphosphate><undergrad><undergraduate><undergraduate student><virtual><virtual screening><virtual screenings><α-helix>
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Yao Athanase Houndonougbo

EASTERN WASHINGTON UNIVERSITY, CHENEY, WA

Exploratory lead · 20/100
Solid budget
Active award
$354,861
FY 2024

Project Title

Computational and biochemical screening for the discovery of molecules that stabilize ITPA clinical variants

Grant Number:

2R15GM112121-02

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2015

End Date:

8/31/2027

Project Abstract

Project Summary/Abstract Human inosine triphosphate pyrophosphohydrolase (ITPA) is a protective enzyme that is essential for life. ITPA hydrolyzes inosine triphosphate (ITP) to the monophosphate form (IMP) to keep the nucleoside triphosphate from interfering with normal cellular processes and/or inc...

Research Terms

<1-Beta-D-ribofuranosyl-1,2,4-triazolo-3-carboxamide><1-Beta-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide><Address><Adopted><Affect><Affinity><Assay><Binding><Binding Sites><Bioassay><Biochemical><Biochemistry><Biological Assay><Biological Chemistry><Cancers><Catalysis><Cell Function><Cell Physiology><Cell Process><Cellular Function><Cellular Physiology><Cellular Process><Clinical><Collaborations><Combining Site><Complex><Computer Models><Computer Simulation><Computer based Simulation><Computerized Models><Data><Defect><Development><Disease><Disorder><Docking><Drugs><Effectiveness><Encephalopathies><Enzyme Gene><Enzyme Kinetics><Enzymes><Funding><Genetic Alteration><Genetic Change><Genetic defect><Goals><HPLC><Health><High Performance Liquid Chromatography><High Pressure Liquid Chromatography><High Speed Liquid Chromatography><High Throughput Assay><Human><ITP pyrophosphohydrolase><ITPase><Individual><Inosine><Investigators><Kinetics><Lead><Libraries><Life><Ligand Binding><Ligands><Lobe><Malignant Neoplasms><Malignant Tumor><Medication><Methods><Modern Man><Molecular><Molecular Dynamics Simulation><Molecular Interaction><Mutation><NIH><National Institutes of Health><Nucleic Acids><ODF factor><OPGL protein><Orphan Disease><Osteoclast Differentiation Factor><Osteoprotegerin Ligand><Outcome><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pb element><Personalized medical approach><Pharmaceutical Agent><Pharmaceutical Preparations><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Proteins><Publications><RANK ligand><Rare Diseases><Rare Disorder><Reaction><Reactive Site><Receptor Activator of Nuclear Factor Kappa B Ligand><Research><Research Personnel><Researchers><Resource Sharing><Ribavirin><Ribovirin><Role><Scientific Publication><Subcellular Process><TNF-Related Activation-Induced Cytokine><TRANCE protein><Testing><Tribavirin><Tumor Necrosis Factor Ligand Superfamily Member 11><United States National Institutes of Health><Universities><Variant><Variation><Washington><Work><alpha helix><chemical library><clinical relevance><clinically relevant><computational modeling><computational models><computational simulation><computer based models><computerized modeling><computerized simulation><design><designing><developmental><drug discovery><drug-like chemical><drug-like compound><drug-like molecule><drug/agent><enzyme activity><epileptic encephalopathies><experience><experiment><experimental research><experimental study><experiments><flexibility><flexible><genome mutation><heavy metal Pb><heavy metal lead><high throughput screening><in silico><individualized approach><infancy><infantile><innovate><innovation><innovative><inosine triphosphatase><inosine triphosphate pyrophosphohydrolase><insight><lobes><malignancy><molecular dynamics><mutant><neoplasm/cancer><nucleoside triphosphate><orphan disorder><patient oriented outcomes><personalized approach><pharmaceutical><precision approach><protein folding><screening><screenings><simulation><small molecule><small molecule libraries><social role><tailored approach><thiopurine><tool><triphosphate><tripolyphosphate><undergrad><undergraduate><undergraduate student><virtual><virtual screening><virtual screenings><α-helix>
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Emily Barkley-Levenson

HOFSTRA UNIVERSITY, HEMPSTEAD, NY

Exploratory lead · 20/100
Solid budget
Active award
$348,726
FY 2023

Project Title

Characterizing Decision-Making in Anorexia Nervosa Under Conditions of Risk and Ambiguity using Computational Neuroimaging

Grant Number:

1R15MH128896-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT Anorexia nervosa (AN) is the deadliest of all mental illnesses and is associated with significant medical consequences and functional impairment. Despite significant research efforts, the etiology of the disorder remains unknown, and outcomes from existing psychological trea...

Research Terms

<21+ years old><Active Follow-up><Adult><Adult Human><Age><Anorexia Nervosa><Attitude><Award><BMI><BMI percentile><BMI z-score><Behavior><Behavioral><Body Weight><Body mass index><Causality><Cell Communication and Signaling><Cell Signaling><Choice Behavior><Choices and Control><Chronic><Clinical><Clinical Research><Clinical Study><Cognition><Cognitive><Cognitive Manifestations><Cognitive Symptoms><Computing Methodologies><Data><Decision Making><Development><Disease><Disease model><Disorder><Etiology><Evidence based treatment><Failure><Fear><Fecundability><Fecundity><Female><Fertility><Food><Fright><Functional impairment><Goals><Individual><Individual Differences><Interruption><Intervention><Intervention Strategies><Intracellular Communication and Signaling><Knowledge><Lateral><Link><Maintenance><Measures><Medial><Medical><Mental disorders><Mental health disorders><Modeling><Neurobehavioral Manifestations><Neurobehavioral Signs and Symptoms><Neurobiology><Neurocognitive><Neurosciences><Organism><Outcome><Pattern><Performance><Population><Population Control><Prefrontal Cortex><Probability><Process><Psychiatric Disease><Psychiatric Disorder><Quetelet index><Reporting><Research><Research Resources><Resources><Risk><Scanning><Secondary to><Services><Signal Transduction><Signal Transduction Systems><Signaling><Specificity><Subgroup><Symptoms><Testing><Theoretic Models><Theoretical model><Time><Treatment outcome><Uncertainty><Universities><Ventral Striatum><Weight><Weight Gain><Weight Increase><Work><active followup><adulthood><aged><ages><alleviate symptom><ameliorating symptom><behavior response><behavioral economics><behavioral response><biobehavior><biobehavioral><biological signal transduction><body weight gain><body weight increase><career><causation><clinical relevance><clinically relevant><computational methodology><computational methods><computational neuroscience><computer based method><computer methods><computing method><cost><decrease symptom><design><designing><developmental><diet restriction><dietary><dietary restriction><disease causation><disorder model><doubt><effective intervention><experience><fewer symptoms><follow up><follow-up><followed up><followup><functional disability><gastrointestinal><graduate student><improved><insight><interest><interventional strategy><living system><mental illness><mortality><neural><neural imaging><neural mechanism><neuro-imaging><neurobehavioral><neurobehavioral symptom><neurobehavioral test><neurobiological><neuroimaging><neurological imaging><neuromechanism><psychiatric illness><psychologic><psychological><psychological disorder><reduce symptoms><relieves symptoms><response><restraint><restricted diet><standard care><standard treatment><symptom alleviation><symptom reduction><symptom relief><undergrad><undergraduate><undergraduate student><weights><wt gain>
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TERESA DRULIA

TEXAS CHRISTIAN UNIVERSITY, FORT WORTH, TX

Exploratory lead · 20/100
Solid budget
Active award
$340,417
FY 2024

Project Title

Translaryngeal Vibration for Hyperfunctional Voice Disorders

Grant Number:

1R15DC021255-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2024

End Date:

8/31/2027

Project Abstract

PROJECT SUMMARY / ABSTRACT High-quality research designs have demonstrated that voice therapy has a positive impact on hyperfunctional voice disorders associated with muscle tension dysphonia (MTD). Among the options of behavioral voice therapy for MTD, one of the most effective evidence-based appro...

Research Terms

<Activities of Daily Living><Activities of everyday life><Address><After Care><After-Treatment><Aftercare><Behavioral><Blinded><Causality><Clinical><Clinical Research><Clinical Study><Communication><Diagnosis><Disease><Disorder><Dose><Dysphonia><Economic Income><Economical Income><Etiology><Financial Hardship><Frequencies><Goals><Income><Individual><Investigation><Investigators><Language><Lesion><Loudness><Measures><Medical Rehabilitation><Meta-Analysis><Modality><Muscle Tension><Muscular Tension><Neural Receptors><Neuroreceptors><Normal Range><Normal Values><Outcome><Outcome Measure><Pathologist><Patients><Phonation><Phonation Disorders><Physiology><Population><Prevalence><Public Health><Publishing><QOL><Quality of life><R-Series Research Projects><R01 Mechanism><R01 Program><Randomized, Controlled Trials><Rehabilitation><Rehabilitation Outcome><Rehabilitation therapy><Reporting><Research><Research Design><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Science><Sensory Receptors><Societies><Speech><Speech-Language Pathology><Stretch Receptors><Stretching><Students><Study Type><Surface><Treatment Effectiveness><Treatment outcome><Voice><Voice Disorders><Voice Quality><Work><causation><clinical applicability><clinical application><clinical efficacy><clinical practice><compare treatment><cost><daily living function><daily living functionality><determine efficacy><disability><disease causation><effective intervention><effective therapy><effective treatment><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><evidence base><examine efficacy><expectation><experience><financial adversity><financial burden><financial distress><financial insecurity><financial strain><financial stress><flexibility><flexible><functional ability><functional capacity><health care service><healthcare service><improved><incomes><innovate><innovation><innovative><insurance claims><longitudinal design><measurable outcome><novel><outcome measurement><placebo group><post treatment><randomized control trial><randomized, clinical trials><rehab therapy><rehabilitative><rehabilitative outcome><rehabilitative therapy><research study><response><sham group><study design><tool><treatment comparison><treatment effect><vibration><vocalization><voice therapy>
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Gillian Fischer

CALIFORNIA STATE UNIV-DOMINGUEZ HILLS, CARSON, CA

Exploratory lead · 18/100
Solid budget
Team-scale grant
$294,000
FY 2022

Project Title

SPAD at California State University Dominguez Hills

Grant Number:

5UC2GM137439-03

Activity Code:

UC2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2020

End Date:

4/30/2024

Project Abstract

Project Summary California State University, Dominguez Hills (CSUDH) is a public Hispanic-serving, minority-serving, primarily undergraduate institution (PUI). As a PUI, CSUDH focuses more on teaching than research, and faculty have heavy teaching loads. This limits faculty time for grantwriting an...

Research Terms

<Address><Affinity><Applications Grants><Attainment Rate><Award><Biomedical Research><California><Complex><Consult><Development and Research><Doctor of Philosophy><E-Mail><EXTMR><Educational process of instructing><Electronic Mail><Email><Ensure><Extramural><Extramural Activities><Face><Faculty><Funding><Future><Generalized Growth><Goals><Graduate Education><Graduation Rates><Grant><Grant Proposals><Growth><Health><Hispanic><Hispanic-serving Institution><Hybrids><Individual><Institution><Institutional Policy><Investigators><Investments><Knowledge><Low income><Mentors><Mentorship><Methods><Minority><Minority-Serving Institution><NIH><National Institutes of Health><Ph.D.><PhD><Police><Policies><Population><Population Scientist Supplement (R25)><Preparation><Preparedness><Principal Investigator><Procedures><R & D><R&D><R-Series Research Projects><R01 Mechanism><R01 Program><R25 Award><Readiness><Recommendation><Reporting><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Proposals><Research Resources><Researchers><Resources><Role><Science><Services><Sister><Solid><Strategic Planning><Students><System><Teaching><Time><Tissue Growth><Training><Training Programs><Translating><Underrepresented Groups><Underrepresented Populations><Underrepresented Students><United States National Institutes of Health><Universities><Writing><academic program><base><career><depository><design><designing><electronic communication><experience><faces><facial><faculty research><innovate><innovation><innovative><member><minority institution><next generation><ontogeny><operation><professor><programs><repository><research and development><response><service programs><social role><teacher><tenure process><tenure track><under representation of groups><under represented groups><under represented people><under represented populations><undergrad><undergraduate><undergraduate research><undergraduate research experience><undergraduate research opportunities><undergraduate research programs><undergraduate student><underrepresentation of groups><underrepresented people><web site><website>
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Sheree Michelle Schrager

CALIFORNIA STATE UNIV-DOMINGUEZ HILLS, CARSON, CA

Exploratory lead · 18/100
Solid budget
Team-scale grant
$294,000
FY 2022

Project Title

SPAD at California State University Dominguez Hills

Grant Number:

5UC2GM137439-03

Activity Code:

UC2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2020

End Date:

4/30/2024

Project Abstract

Project Summary California State University, Dominguez Hills (CSUDH) is a public Hispanic-serving, minority-serving, primarily undergraduate institution (PUI). As a PUI, CSUDH focuses more on teaching than research, and faculty have heavy teaching loads. This limits faculty time for grantwriting an...

Research Terms

<Address><Affinity><Applications Grants><Attainment Rate><Award><Biomedical Research><California><Complex><Consult><Development and Research><Doctor of Philosophy><E-Mail><EXTMR><Educational process of instructing><Electronic Mail><Email><Ensure><Extramural><Extramural Activities><Face><Faculty><Funding><Future><Generalized Growth><Goals><Graduate Education><Graduation Rates><Grant><Grant Proposals><Growth><Health><Hispanic><Hispanic-serving Institution><Hybrids><Individual><Institution><Institutional Policy><Investigators><Investments><Knowledge><Low income><Mentors><Mentorship><Methods><Minority><Minority-Serving Institution><NIH><National Institutes of Health><Ph.D.><PhD><Police><Policies><Population><Population Scientist Supplement (R25)><Preparation><Preparedness><Principal Investigator><Procedures><R & D><R&D><R-Series Research Projects><R01 Mechanism><R01 Program><R25 Award><Readiness><Recommendation><Reporting><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Proposals><Research Resources><Researchers><Resources><Role><Science><Services><Sister><Solid><Strategic Planning><Students><System><Teaching><Time><Tissue Growth><Training><Training Programs><Translating><Underrepresented Groups><Underrepresented Populations><Underrepresented Students><United States National Institutes of Health><Universities><Writing><academic program><base><career><depository><design><designing><electronic communication><experience><faces><facial><faculty research><innovate><innovation><innovative><member><minority institution><next generation><ontogeny><operation><professor><programs><repository><research and development><response><service programs><social role><teacher><tenure process><tenure track><under representation of groups><under represented groups><under represented people><under represented populations><undergrad><undergraduate><undergraduate research><undergraduate research experience><undergraduate research opportunities><undergraduate research programs><undergraduate student><underrepresentation of groups><underrepresented people><web site><website>
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CYNTHIA A. CRAWFORD

CALIFORNIA STATE UNIV SAN BERNARDINO, SAN BERNARDINO, CA

Exploratory lead · 18/100
Solid budget
Team-scale grant
$290,581
FY 2022

Project Title

SPAD at California State University San Bernardino

Grant Number:

5UC2GM137444-03

Activity Code:

UC2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2020

End Date:

4/30/2025

Project Abstract

California State University San Bernardino (CSUSB) is a comprehensive, primarily undergraduate minority serving institution with 70% of its student population from under-represented groups. We have seen a decline in externally sponsored biomedical/biobehavioral research. In 2018 our sponsored progra...

Research Terms

<Academic Research Enhancement Awards><Accounting><Accounts Payable><Administrator><Advisory Services><Applications Grants><Award><Biomedical Research><California><Charge><Contracting Opportunities><Contracts><Cost Savings><Development><Development and Research><Educational process of instructing><Expenditure><Facilities and Administrative Costs><Faculty><Financial Support><Foundations><Future><Generalized Growth><Goals><Grant><Grant Proposals><Growth><Health Disparities Research><Health disparities related research><Hispanic-serving Institution><Human Resources><Incentives><Indirect Costs><Infrastructure><Manpower><Minority-Serving Institution><NIH><National Institutes of Health><National Research Council><P01 Mechanism><P01 Program><Participant><Phase><Position><Positioning Attribute><Process><Program Development><Program Project Grant><Program Research Project Grants><Program Sustainabilities><Program Sustainability><R & D><R&D><R-Series Research Projects><R01 Mechanism><R01 Program><R15 Mechanism><R15 Program><Recommendation><Reporting><Research><Research Grants><Research Infrastructure><Research Program Projects><Research Project Grants><Research Projects><Research Resources><Research Training><Resources><Science><Science, Technology, Engineering and Math><Science, Technology, Engineering and Mathematics><Services><Specialist><Strategic Planning><Structure><Students><Teaching><Tissue Growth><Underrepresented Groups><Underrepresented Populations><United States National Institutes of Health><Universities><base><biobehavior><biobehavioral><developmental><faculty research><faculty support><financial assistance><improved><minority health disparity><minority institution><minority undergraduate><ontogeny><operation><peer><personnel><programs><research and development><under representation of groups><under represented groups><under represented people><under represented populations><undergrad><undergraduate><undergraduate research><undergraduate student><underrepresentation of groups><underrepresented people>
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Anna Marie Eiring

TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER AT EL PASO, EL PASO, TX

Exploratory lead · 10/100
Solid budget
$480,000
FY 2024

Project Title

G0S2 and lipid metabolism in the regulation of hematopoietic development

Grant Number:

1R15HL172157-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

9/1/2024

Project Abstract

PROJECT SUMMARY/ABSTRACT The long-term goals of this proposal are two-fold: (i) understand the functional role of G0/G1 switch gene 2 (G0S2) during normal and obese hematopoiesis, and (ii) leverage that understanding for the development of new therapeutics to treat multiple obesity-related condition...

Research Terms

<(TNF)-α><Acyltransferase><Adipocytes><Adipose Cell><Adipose tissue><Admission><Admission activity><Adult-Onset Diabetes Mellitus><American diet><Apoptosis><Apoptosis Pathway><Autoregulation><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Binding><Blood><Blood Cells><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Blood Precursor Cell><Blood Reticuloendothelial System><Body Tissues><Bone Marrow><Bone Marrow Blood-Deriving Cell><Bone Marrow Blood-Forming Cell><Bone Marrow Cells><Bone Marrow Reticuloendothelial System><Bone Marrow Stem Cell><Cachectin><Cancers><Cardiac Diseases><Cardiac Disorders><Cell Body><Cell Cycle><Cell Division Cycle><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Chronic><Colony Stimulating Factor 3><Data><Defect><Development><Disease><Disorder><Doctor of Philosophy><EC 2.3><Ectopic Expression><Education><Educational aspects><Energy Expenditure><Energy Metabolism><Enzyme Gene><Enzymes><Fat Cells><Fatty Tissue><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Free Fatty Acids><Future><Goals><Granulocyte Colony-Stimulating Factor><HPGF><HSC differentiation><HSC production><HSC regeneration><HSC self-renewal><Health><Health Sciences><Heart Diseases><Heat Production><Hematologic Body System><Hematologic Organ System><Hematopoiesis><Hematopoietic><Hematopoietic Body System><Hematopoietic Cell Production><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic System><Hematopoietic stem cells><Hepatic Cells><Hepatic Parenchymal Cell><Hepatocyte><Hepatocyte-Stimulating Factor><High Fat Diet><Hispanic><Hispanic-serving Institution><Homeostasis><Hybridoma Growth Factor><Hypertension><IFN-beta 2><IFNB2><IL-6><IL6 Protein><Immune><Immunes><Individual><Inflammation><Inflammatory><Insulin Resistance><Interleukin-6><Jobs><KO mice><Ketosis-Resistant Diabetes Mellitus><Knock-out Mice><Knockout Mice><Knowledge><Laboratories><Lactation><Life><Link><Lipase><Lipids><Lipocytes><Lipolysis><Liver><Liver Cells><Location><MGI-2><MOPA><Macrophage><Macrophage-Derived TNF><Malignant Neoplasms><Malignant Tumor><Marrow><Marrow Neutrophil><Mature Lipocyte><Mature fat cell><Maturity-Onset Diabetes Mellitus><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic syndrome><Mexico><Mice><Mice Mammals><Molecular><Molecular Interaction><Monocyte-Derived TNF><Murine><Mus><Myelogenous><Myeloid><Myeloid Cells><Myeloid Differentiation-Inducing Protein><Mφ><NIDDM><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Nonesterified Fatty Acids><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Null Mouse><Obese Mice><Obesity><Occupations><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Pathogenesis><Pathologic><Pathway interactions><Peripheral Blood Cell><Ph.D.><PhD><Phenotype><Physiological Homeostasis><Plasmacytoma Growth Factor><Pluripoietin><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Population><Prevalence><Process><Production><Professional Positions><Programmed Cell Death><Proteins><Red Marrow><Regulation><Research><Research Assistant><Risk><Rodent Model><Role><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Staining method><Stains><Students><Subcellular Process><Switch Genes><T2 DM><T2D><T2DM><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Testing><Texas><Thermogenesis><Thesaurismosis><Tissues><Transferase><Transferase Gene><Triacylglycerol><Triacylglycerol Hydrolase><Triacylglycerol Lipase><Triacylglycerol acylhydrolase><Tributyrinase><Triglyceridase><Triglyceride Lipase><Triglycerides><Triolean Hydrolase><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><United States><Universities><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Weight><adipose><adiposity><adolescent minority><adult onset diabetes><blood cell formation><blood cell progenitor><blood progenitor><blood stem cell><blood stem cell self-renewal><blood-forming stem cell><bone cell><bone marrow stromal stem cell><career><comparing females and males><comparing women and men><corpulence><cytokine><design><designing><developmental><diet-associated obesity><diet-induced obesity><diet-related obesity><energy balance><experiment><experimental research><experimental study><experiments><fat metabolism><fatty acid oxidation><females compared to males><females compared with males><females versus males><females vs males><fitness><flow cytophotometry><graduate student><granulocyte colony stimulating factor><heart disorder><hematopoietic differentiation><hematopoietic progenitor><hematopoietic progenitor cell differentiation><hematopoietic progenitor cell fate><hematopoietic progenitor cell self-renewal><hematopoietic progenitor differentiation><hematopoietic stem and progenitor cell fate><hematopoietic stem cell differentiation><hematopoietic stem cell fate><hematopoietic stem cell production><hematopoietic stem cell regeneration><hematopoietic stem cell self-renewal><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><hepatic body system><hepatic organ system><high blood pressure><human disease><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><in vivo><inhibitor><insulin resistant><insulin tolerance><interferon beta 2><ketosis resistant diabetes><lactating><lactational><light microscopy><lipid metabolism><lipidomics><lysophosphatidic acid><malignancy><maturity onset diabetes><metabolism disorder><metabolism measurement><metabolomics><metabonomics><minority children><minority student><minority youth><monooleylphosphatidate><monooleylphosphatidic acid><mouse model><murine model><mutant><neoplasm/cancer><neutrophil><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><ob/ob mouse><obese individuals><obese people><obese person><obese population><obese subjects><obesity prevention><pathway><pediatric minority><peripheral blood><prevent obesity><programs><reconstitute><reconstitution><response><social role><training opportunity><tributyrase><type 2 DM><type II DM><type two diabetes><weights><white adipose tissue><women compared to men><women compared with men><women versus men><women vs men><yellow adipose tissue><young minority>
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Hwai-Chen Guo

UNIVERSITY OF MASSACHUSETTS LOWELL, LOWELL, MA

Exploratory lead · 10/100
Solid budget
$455,940
FY 2022

Project Title

Structural and Bioinformatics Analyses of M1 Aminopeptidases

Grant Number:

2R15GM128152-02

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2018

End Date:

3/31/2026

Project Abstract

Project Summary Endoplasmic reticulum aminopeptidase 1 (ERAP1) and insulin-regulated aminopeptidase (IRAP) belong to the oxytocinase subfamily of M1 aminopeptidases (M1APs), which are a diverse family of metalloenzymes involved in a wide range of functions including cell maintenance, development, a...

Research Terms

<AD dementia><Alzheimer><Alzheimer Type Dementia><Alzheimer disease><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease dementia><Alzheimers Dementia><Alzheimers disease><Aminopeptidase><Antigens><Assay><Autoimmune Status><Autoimmunity><Bestatin><Binding><Binding Sites><Bio-Informatics><Bioassay><Biochemical><Bioinformatics><Biologic Assays><Biological Assay><Biophysics><C-terminal><Cancers><Catalytic Core><Catalytic Domain><Catalytic Region><Catalytic Site><Catalytic Subunit><Cell Growth and Maintenance><Cell Maintenance><Cell Mediated Immunology><Cell-Mediated Immunity><Cellular Immunity><Chronic Disease><Chronic Illness><Combining Site><Communicable Diseases><Complex><Crystallization><Cyclicity><Development><Disease><Disorder><Distal><Docking><Endoplasmic Reticulum><Environment><Enzyme Gene><Enzymes><Ergastoplasm><Esteroproteases><Family><Family member><Hand><Histocompatibility Complex><Histocompatibility Complices><Human><Humulin R><Hypertension><Immune><Immunes><In Vitro><Infectious Disease Pathway><Infectious Diseases><Infectious Disorder><Insulin><Knowledge><Lead><Libraries><Ligands><Major Histocompatibility Complex><Major Histocompatibility Complices><Malaria><Malignant Neoplasms><Malignant Tumor><Modern Man><Molecular><Molecular Interaction><Mutation Analysis><Novolin R><Paludism><Paralysis Agitans><Parkinson><Parkinson Disease><Parkinson's disease><Parkinsons disease><Pb element><Peptidases><Peptide Hydrolases><Peptides><Periodicity><Plasmodium Infections><Play><Primary Parkinsonism><Primary Senile Degenerative Dementia><Protease Gene><Proteases><Proteinases><Proteolytic Enzymes><Public Health><Reactive Site><Regular Insulin><Research><Rhythmicity><Single Crystal Diffraction><Site><Specificity><Structure><Substrate Specificity><Testing><Therapeutic><Ubenimex><Universities><Validation><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Viral Diseases><Virus Diseases><X Ray Crystallographies><X-Ray Crystallography><X-Ray Diffraction Crystallography><X-Ray/Neutron Crystallography><Xray Crystallography><analog><base><biophysical foundation><biophysical principles><biophysical sciences><chronic disorder><combinatorial><comparative><dementia of the Alzheimer type><design><designing><developmental><fight against><graduate student><heavy metal Pb><heavy metal lead><high blood pressure><human disease><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><immunogen><improved><in silico><inhibitor><insight><malignancy><member><metalloenzyme><neoplasm/cancer><novel><pathogen><peptide structure><pharmacophore><preference><primary degenerative dementia><screening><senile dementia of the Alzheimer type><side effect><small molecule><therapeutic target><undergrad><undergraduate><undergraduate research experience><undergraduate research opportunities><undergraduate research programs><undergraduate student><viral infection><virus infection><virus-induced disease>
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Brett Peters

OHIO UNIVERSITY ATHENS, ATHENS, OH

Exploratory lead · 10/100
Solid budget
$453,000
FY 2022

Project Title

Examining emotion regulation processes in social anxiety from an interpersonal and observational perspective

Grant Number:

1R15MH125289-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2022

End Date:

7/14/2025

Project Abstract

PROJECT SUMMARY/ABSTRACT Social anxiety disorder (i.e., social phobia) is one of the most common and debilitating psychiatric disorders, with lifetime prevalence estimates around 13% and onset peaking in early adulthood. Characterized by excessive and persistent fear of social or performance situati...

Research Terms

<Academic Research Enhancement Awards><Acute><Address><Adopted><Aeroseb-HC><Arousal><Basic Research><Basic Science><Behavioral><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Causality><Cetacort><Code><Coding System><Cort-Dome><Cortef><Cortenema><Cortisol><Cortispray><Cortril><Dermacort><Dimensions><Disease><Disorder><Distress><Eldecort><Emotional><Emotions><Empirical Research><Etiology><Event><Exhibits><Family><Fear><Friends><Friendships><Fright><Funding Mechanisms><Heart Vascular><Hydrocortisone><Hydrocortone><Hytone><Impairment><Individual><Interpersonal Interaction><Interpersonal Relations><Intervention><Intervention Strategies><Laboratories><Life><Maintenance><Measures><Mental disorders><Mental health disorders><Mission><NIMH><National Institute of Mental Health><Nature><Neuroendocrine><Neuroendocrine System><Neurosecretory Systems><Nutracort><Participant><Patient Self-Report><Pattern><Performance><Peripheral Resistance><Persons><Physiologic Psychology><Physiological Psychology><Prevalence><Process><Proctocort><Psychiatric Disease><Psychiatric Disorder><Psychopathology><Psychophysiological><Psychophysiology><Public Health><Public Speaking><QOL><Quality of life><R15 Mechanism><R15 Program><RDoC><Reporting><Research><Research Domain Criteria><Salivary><Self-Report><Shapes><Social Anxiety Disorder><Social Environment><Social Interaction><Social Phobia><Social Problems><Standardization><Students><Symptoms><Systemic Vascular Resistance><Task Performances><Testing><Theoretic Models><Theoretical model><Time><Total Peripheral Resistance><Trier Social Stress Test><Work><abnormal psychology><anxiety states><anxiety symptoms><anxious><anxious symptom><behavior observation><behavioral observation><causation><circulatory system><cost><data-driven model><diaries><disease causation><dyadic interaction><dysphoria><early adolescence><early adulthood><emerging adult><emotion regulation><emotional regulation><experience><graduate student><improved><in vivo><innovate><innovation><innovative><interpersonal relationship><interventional strategy><meetings><member><mental illness><physiopsychology><primary outcome><psychiatric illness><psycho-physiological><psychological disorder><recruit><response><ruminate><rumination><ruminative><secondary outcome><social><social anxiety><social climate><social context><social disturbance><social influence><social stresses><social stressor><socioenvironment><socioenvironmental><theories><trait><undergrad><undergraduate><undergraduate student>
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Peggy Mycek Zoccola

OHIO UNIVERSITY ATHENS, ATHENS, OH

Exploratory lead · 10/100
Solid budget
$453,000
FY 2022

Project Title

Examining emotion regulation processes in social anxiety from an interpersonal and observational perspective

Grant Number:

1R15MH125289-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2022

End Date:

7/14/2025

Project Abstract

PROJECT SUMMARY/ABSTRACT Social anxiety disorder (i.e., social phobia) is one of the most common and debilitating psychiatric disorders, with lifetime prevalence estimates around 13% and onset peaking in early adulthood. Characterized by excessive and persistent fear of social or performance situati...

Research Terms

<Academic Research Enhancement Awards><Acute><Address><Adopted><Aeroseb-HC><Arousal><Basic Research><Basic Science><Behavioral><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Causality><Cetacort><Code><Coding System><Cort-Dome><Cortef><Cortenema><Cortisol><Cortispray><Cortril><Dermacort><Dimensions><Disease><Disorder><Distress><Eldecort><Emotional><Emotions><Empirical Research><Etiology><Event><Exhibits><Family><Fear><Friends><Friendships><Fright><Funding Mechanisms><Heart Vascular><Hydrocortisone><Hydrocortone><Hytone><Impairment><Individual><Interpersonal Interaction><Interpersonal Relations><Intervention><Intervention Strategies><Laboratories><Life><Maintenance><Measures><Mental disorders><Mental health disorders><Mission><NIMH><National Institute of Mental Health><Nature><Neuroendocrine><Neuroendocrine System><Neurosecretory Systems><Nutracort><Participant><Patient Self-Report><Pattern><Performance><Peripheral Resistance><Persons><Physiologic Psychology><Physiological Psychology><Prevalence><Process><Proctocort><Psychiatric Disease><Psychiatric Disorder><Psychopathology><Psychophysiological><Psychophysiology><Public Health><Public Speaking><QOL><Quality of life><R15 Mechanism><R15 Program><RDoC><Reporting><Research><Research Domain Criteria><Salivary><Self-Report><Shapes><Social Anxiety Disorder><Social Environment><Social Interaction><Social Phobia><Social Problems><Standardization><Students><Symptoms><Systemic Vascular Resistance><Task Performances><Testing><Theoretic Models><Theoretical model><Time><Total Peripheral Resistance><Trier Social Stress Test><Work><abnormal psychology><anxiety states><anxiety symptoms><anxious><anxious symptom><behavior observation><behavioral observation><causation><circulatory system><cost><data-driven model><diaries><disease causation><dyadic interaction><dysphoria><early adolescence><early adulthood><emerging adult><emotion regulation><emotional regulation><experience><graduate student><improved><in vivo><innovate><innovation><innovative><interpersonal relationship><interventional strategy><meetings><member><mental illness><physiopsychology><primary outcome><psychiatric illness><psycho-physiological><psychological disorder><recruit><response><ruminate><rumination><ruminative><secondary outcome><social><social anxiety><social climate><social context><social disturbance><social influence><social stresses><social stressor><socioenvironment><socioenvironmental><theories><trait><undergrad><undergraduate><undergraduate student>
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Shahnaz Aziz

EAST CAROLINA UNIVERSITY, GREENVILLE, NC

Exploratory lead · 10/100
Solid budget
$451,063
FY 2022

Project Title

Association between workaholism and fasting glucose/insulin, insulin sensitivity, and lipids.

Grant Number:

1R15DK128608-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

2/28/2026

Project Abstract

PROJECT SUMMARY A range of factors contribute to the development and progression of type 2 diabetes (T2D). These factors include diet, exercise, genetics, environmental exposures, socioeconomics, age, sex, geography, and behavioral patterns. Among behavioral patterns, emerging evidence suggests work...

Research Terms

<Absenteeism><Adult-Onset Diabetes Mellitus><Age><Alcohol Chemical Class><Alcohols><Apoplexy><BMI><BMI percentile><BMI z-score><Behavior><Behavioral><Blood Coagulation Factor I><Blood Coagulation Factor One><Blood Factor One><Blood Pressure><Blood Sample><Blood specimen><Body mass index><Brain Vascular Accident><Caffeine><Caloric Intake><Causality><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Cholesterol><Coagulation Factor I><Coagulation Factor One><Coronary Disease><Coronary heart disease><D-Glucose><Data><Data Reporting><Development><Dextrose><Disease><Disorder><Drug usage><Drugs><Dyslipidemias><Employee Health><Energy Intake><Environmental Exposure><Ethnic Origin><Ethnicity><Etiology><Factor I><Factor One><Fasting><Fibrinogen><Future><Genetic><Geography><Glucose><Goals><HDL><HDL Lipoproteins><Health><Health Care Costs><Health Costs><Healthcare Costs><Heavy Lipoproteins><High Density Lipoproteins><High density lipoprotein><Hour><Humulin R><Impairment><Industrial Psychology><Industrial/Organizational Psychology><Insulin><Insulin Resistance><Investigators><Ketosis-Resistant Diabetes Mellitus><Knowledge><LDL><LDL Lipoproteins><Link><Lipids><Longitudinal Studies><Low-Density Lipoproteins><Maturity-Onset Diabetes Mellitus><Mediating><Mediator><Mediator of Activation><Mediator of activation protein><Medication><Metabolic><Minority Groups><Minority People><Minority Population><Minority individual><Modeling><NIDDM><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Novolin R><OGTT><Oral Glucose Tolerance Test><Outcome><Patient Self-Report><Pattern><Pharmaceutic Preparations><Pharmaceutical Preparations><Physical activity><Play><Prediabetes><Prediabetes syndrome><Prediabetic State><Psychological Factors><Quetelet index><Race><Racial Group><Racial Stocks><Regular Insulin><Research><Research Personnel><Researchers><Role><Science><Self-Report><Sleep Disorders><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Stress><Stroke><Students><Survey Instrument><Surveys><T2 DM><T2D><T2DM><Testing><Training><Triacylglycerol><Triglycerides><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Weight><Work><adult onset diabetes><ages><alpha-Lipoproteins><atherosclerotic heart disease><base><beta-Lipoproteins><brain attack><burn-out><burnout><caloric dietary content><causation><cerebral vascular accident><cerebrovascular accident><coronary disorder><data representation><developmental><diabetes risk><diet and exercise><disease causation><drug use><drug/agent><fasted><fasting glucose><fasting plasma glucose><fasts><insulin regulation><insulin resistant><insulin sensitivity><intervention design><ketosis resistant diabetes><long-term study><longitudinal outcome studies><longterm study><macrovascular complication><macrovascular disease><maturity onset diabetes><pandemic><pandemic disease><pre-diabetes><pre-diabetic><prediabetic><recruit><sex><sleep diseases><sleep dysfunction><sleep illness><sleep problem><social role><socio-economic><socio-economically><socioeconomically><socioeconomics><statistical analysis><statistics><therapy design><treatment design><type 2 DM><type II DM><type two diabetes>
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Katherine Jean Forney

OHIO UNIVERSITY ATHENS, ATHENS, OH

Exploratory lead · 10/100
Solid budget
$450,656
FY 2022

Project Title

Fear, gastrointestinal distress, and interoception: Physiological and psychological mechanisms in eating disorders

Grant Number:

1R15MH128703-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2022

End Date:

12/31/2025

Project Abstract

7. Project Summary/Abstract Eating disorders are prevalent, costly, and deadly psychiatric illnesses. Current empirically-supported interventions fail to achieve symptom remission in the majority of patients. Gastrointestinal (GI) distress (e.g., nausea, stomachache) is one barrier that contributes ...

Research Terms

<Academic Research Enhancement Awards><Address><Adherence><Affect><American><Autoregulation><Award><Behavior><Brain><Brain Nervous System><CCK><Cessation of life><Cholecystokinin><Cross-Over Designs><Crossover Design><Death><Disease remission><Distress><Eating><Eating Behavior><Eating Disorders><Electrodermal Response><Encephalon><Ensure><Evidence based treatment><Fasting><Fats><Fatty acid glycerol esters><Fear><Food><Food Intake><Food or Food Product><France><Fright><Galvanic Skin Response><Homeostasis><Individual><Interoception><Intervention><Intervention Strategies><Investigators><L-tyrosyl-L-tyrosine><Link><Maintenance><Mediating><Mediation><Mediator><Mediator of Activation><Mediator of activation protein><Mental disorders><Mental health disorders><Modeling><Nausea><Negotiating><Negotiation><Ohio><PYY Peptide><Pancreozymin><Participant><Patients><Peptide YY><Peptides><Perception><Physiologic><Physiologic Psychology><Physiological><Physiological Homeostasis><Physiological Psychology><Psychiatric Disease><Psychiatric Disorder><Psychogalvanic Reflex><Psychophysiological><Psychophysiology><R15 Mechanism><R15 Program><Remission><Reporting><Research><Research Personnel><Researchers><Skin Electric Conductance><Symptoms><Testing><Training><Treatment outcome><Tyr-Tyr><Uropancreozymin><Weight><Weight Gain><Weight Increase><Woman><Yogurt><base><body weight gain><body weight increase><causal diagram><causal model><clinical practice><college student><cost><design><designing><eating pathology><experience><fasted><fasts><food consumption><gastrointestinal><improved><insight><interventional strategy><mental illness><next generation><novel><peptide tyrosine-tyrosine><physiopsychology><psychiatric illness><psycho-physiological><psychoeducation><psychologic><psychological><psychological disorder><response><restrictive eating><skin conductance><success><tyrosyltyrosine><university student><wt gain>
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Jixin Chen

OHIO UNIVERSITY ATHENS, ATHENS, OH

Exploratory lead · 10/100
Solid budget
$448,094
FY 2023

Project Title

Super-Resolution Optical Mapping for DNA Analysis Using Triplex-Forming Oligonucleotides as Stochastic Molecular Probes

Grant Number:

2R15HG009972-02

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

4/30/2026

Project Abstract

Abstract Genome optical mapping is a quality control method for a genome sequencing project. The PI proposes a high- impact and innovative collaborative research project to develop non-invasive stochastic molecular probes for super-resolution genome optical mapping. Super-resolution genome optical m...

Research Terms

<Academic Research Enhancement Awards><Appalachia><Appalachian><Appalachian Region><Area><Bacteriophage lambda><Bar Codes><Base Pairing><Benchmarking><Best Practice Analysis><Binding><Bio-Informatics><Biochemical><Bioinformatics><Biomedical Research><Biotech><Biotechnology><Cell Culture Techniques><Coliphage lambda><Coloring Agents><Computer Software Tools><Consumption><DNA><DNA Fragmentation><DNA analysis><DNA mapping><Data><Data Analyses><Data Analysis><Deoxyribonucleic Acid><Dyes><E coli><E. coli><Educational process of instructing><Enterobacteria phage lambda><Escherichia coli><Evaluation><Female><Fingerprint><Fluorescence><Funding><Genome><Genome Mappings><Goals><High School Student><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><Immobilization><Kinetics><Knowledge><Label><Light><Location><Maps><Measures><Methods><Modification><Molecular><Molecular Interaction><Molecular Probes><NGS Method><NGS system><Ohio><Oligo><Oligonucleotide Probes><Oligonucleotides><Optics><Phage lambda><Photoradiation><Position><Positioning Attribute><Preparation><Quality Control><R-Series Research Projects><R01 Mechanism><R01 Program><R15 Mechanism><R15 Program><Reaction><Research><Research Grants><Research Project Grants><Research Projects><Resolution><Sampling><Secondary School Student><Secondary Student><Single-Stranded DNA><Software Tools><Spinal Column><Spine><Stretching><Students><System><Teaching><Techniques><Time><Training><Training Programs><Underrepresented Ethnic Minority><Underrepresented Minority><Universities><Vertebral column><analyze DNA><associate faculty><associate professor><backbone><barcode><base><bases><benchmark><cell culture><cell cultures><data interpretation><density><design><designing><entire genome><experience><fluorescence imaging><fluorescent imaging><full genome><genome sequencing><graduate school><graduate student><high schoolers><imaging><innovate><innovation><innovative><light microscopy><method development><mid-career faculty><midcareer faculty><nano meter><nanometer><next gen sequencing><next generation sequencing><nextgen sequencing><novel><oligos><optic imaging><optical><optical imaging><orthopedic freezing><preparations><resolutions><restriction enzyme><restriction enzymes><scaffold><scaffolding><single molecule><software toolkit><ssDNA><stem><super high resolution><superresolution><superresolution imaging><ultra high resolution><under-representation of minorities><under-represented minority><undergrad><undergraduate><undergraduate student><underrepresentation of minorities><whole genome>
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Jennifer Toller Erausquin

UNIVERSITY OF NORTH CAROLINA GREENSBORO, GREENSBORO, NC

Exploratory lead · 10/100
Solid budget
$447,922
FY 2022

Project Title

Latent class analysis of syndemic factors associated with HIV care outcomes among women living with HIV in the South

Grant Number:

1R15MH129191-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/13/2022

End Date:

6/30/2025

Project Abstract

Abstract - New strategies are needed to understand the interplay of multiple barriers to HIV care engagement and viral suppression for diverse women living with HIV in the South. The South is a high-risk geographic area, with more than half of the new HIV diagnoses in the U.S., and incidence rates u...

Research Terms

<AIDS><AIDS Virus><AIDS prevention><AIDS/HIV><AIDS/HIV problem><Acquired Immune Deficiency><Acquired Immune Deficiency Syndrome><Acquired Immune Deficiency Syndrome Virus><Acquired Immuno-Deficiency Syndrome><Acquired Immunodeficiency Syndrome><Acquired Immunodeficiency Syndrome Virus><Acquired Immunologic Deficiency Syndrome><Address><Behavior><Behavioral><Black><Black race><CDC><Caring><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Clinical Trials><Cognitive Discrimination><Collaborations><Communities><Community Networks><Continuity of Care><Continuity of Patient Care><Continuum of Care><Country><Data><Data Sources><Death Rate><Development><Discrimination><Environment><Epidemic><Ethnic Origin><Ethnic People><Ethnic Population><Ethnic group><Ethnic individual><Ethnicity><Ethnicity People><Ethnicity Population><Female Health><Female Roles><Florida><Fostering><Foundations><Future><Gender><Geographic Area><Geographic Locations><Geographic Region><Geographical Location><HIV><HIV Prevention><HIV diagnosis><HIV/AIDS><HIV/AIDS prevention><HIV/AIDS problem><Health><Health Inequity><High-Risk Sex><Hispanic><Human Immunodeficiency Viruses><Incidence><Inequalities in Health><Inequities in Health><Intervention><Intervention Strategies><Investigators><LAV-HTLV-III><Latina><Lymphadenopathy-Associated Virus><Medical><Mentorship><Mississippi><Monitor><NIH><NIMH><National Institute of Mental Health><National Institutes of Health><Non-Hispanic><Nonhispanic><North Carolina><Not Hispanic or Latino><Outcome><Persons><Population Study><Prevention><Primary Care><Primary Health Care><Primary Healthcare><Public Health><Qualitative Research><Race><Racial Group><Racial Stocks><Regression Analyses><Regression Analysis><Regression Diagnostics><Reporting><Research><Research Personnel><Research Resources><Researchers><Resources><Risk><Statistical Regression><Strategic Planning><Structural Racism><Structure><Testing><Texas><Transmission><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><United States National Institutes of Health><Universities><Unprotected Sex><Unsafe Sex><Viral><Viral Burden><Viral Load><Viral Load result><Virginia><Virus-HIV><Visit><Woman><Women's Health><Women's Role><anti-retroviral therapy><anti-retroviral treatment><antiretroviral therapy><antiretroviral treatment><base><biobehavior><biobehavioral><care outcomes><cis-female><cis-gender man><cis-gender woman><cis-male><cis-man><cis-woman><cisgender man><cisgender woman><co-morbid><co-morbidity><comorbidity><condomless intercourse><condomless sex><design><designing><develop therapy><developmental><disparity elimination><economic disparity><eliminate disparities><eliminating disparities><ethnicity group><ethnoracial><ethnoracial disparities><evidence base><experience><geographic site><graduate student><health care outcomes><health disparate populations><health disparity populations><health inequalities><healthcare outcomes><high risk><improved><intervention development><interventional strategy><member><men><men's><mortality><multi-racial><multiracial><population based><population-based study><population-level study><psychosocial><racial and ethnic><racial and ethnic disparities><secondary analysis><sex><sexual HIV transmission><sexually transmitted HIV><social norm><social stigma><social structural><social structure><socio-economic><socio-economically><socio-structural><socioeconomically><socioeconomics><sociostructural><stigma><studies of populations><study of the population><syndemic><synergistic epidemic><theories><therapy adherence><therapy development><tool><trans-women><transgender women><transmission process><transwoman><transwomen><treatment development><undergrad><undergraduate><undergraduate research experience><undergraduate research opportunities><undergraduate research programs><undergraduate student><unprotected intercourse>
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Robert L. Harrod

SOUTHERN METHODIST UNIVERSITY, DALLAS, TX

Exploratory lead · 10/100
Solid budget
$445,500
FY 2023

Project Title

Roles of p53-Regulated Pro-Survival Signals in Carcinogenesis by HTLV-1 and High-Risk Subtype HPVs

Grant Number:

1R15CA267892-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/13/2022

End Date:

11/30/2025

Project Abstract

The human T-cell leukemia virus type-1 (HTLV-1) is a delta oncoretrovirus that infects and transforms CD4+ T-cells and causes adult T-cell leukemia/lymphoma (ATLL), an aggressive hematological malignancy that is generally resistant to conventional anticancer therapies. The 3' end of the HTLV-1 genom...

Research Terms

<ATLL><Acetylation><Acetyltransferase><Adult T-Cell Leukemia><Adult T-Cell Leukemia-Lymphoma Virus I><Adult T-Cell Leukemia/Lymphoma><Adult T-Cell Lymphoma/Leukemia><Affinity Chromatography><Algorithms><Amino Acids><Antioncogene Protein p53><Apoptosis><Apoptosis Pathway><Apoptosis Regulation Gene><Apoptosis Regulator><Apoptotic><Base Sequence><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cancer Cause><Cancer Etiology><Cancer Induction><Cancer Patient><Cancer Treatment><Cancers><Cas nuclease technology><Cell Body><Cell Communication and Signaling><Cell Line><Cell Signaling><CellLine><Cells><Cellular Expansion><Cellular Growth><Cellular Oncogene><Cellular Tumor Antigen P53><Cervical Cancer><Cervical Carcinoma><Cervix Cancer><Cervix Uteri Carcinoma><Cervix carcinoma><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Disease Progression><E6AP><ESA1><Engraftment><Epidermoid Carcinoma><Family><Gene Transcription><Generalized Growth><Genes><Genetic Transcription><Genome><Glycolysis Induction><Growth><HIV-1 TAT-Interacting Protein><HPV><HPV 16><HPV E6><HPV-16><HPV-High Risk><HPV16><HTATIP><HTATIP gene><HTATIP1><HTLV-1><HTLV-I><HTLV1><Hematologic Cancer><Hematologic Malignancies><Hematologic Neoplasms><Hematological Malignancies><Hematological Neoplasms><Hematological Tumor><Hematopoietic Cancer><High Risk Oncogenic HPV><High risk HPV><High risk Human Papillomavirus><High risk Human papilloma virus><Human><Human Papilloma Virus><Human Papillomavirus><Human T-Cell Leukemia Virus I><Human T-lymphotropic virus 1><Human papilloma virus type 16><Human papillomavirus 16><Human papillomavirus type 16><Hypoxia><Hypoxic><Individual><Infectious Human Wart Virus><Infiltration><Inhibition of Apoptosis><Intracellular Communication and Signaling><KAT5><Kinases><Kinetics><L-Lysine><Laboratories><Link><Lysine><Lysine Acetyltransferase 5><MALD-MS><MALDI><MALDI-MS><Maintenance><Malignant Cervical Neoplasm><Malignant Cervical Tumor><Malignant Hematologic Neoplasm><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasm of the Cervix><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Cervix><Malignant Tumor of the Cervix Uteri><Malignant Uterine Cervix Neoplasm><Malignant Uterine Cervix Tumor><Malignant neoplasm of cervix uteri><Maps><Mediating><Messenger RNA><Mitochondria><Modeling><Modern Man><Molecular><Mutate><Nucleotide Sequence><ORFs><Oncogene Products><Oncogene Proteins><Oncogenesis><Oncogenic><Oncogenic Viruses><Oncology><Oncology Cancer><Oncoprotein p53><Oncoproteins><Open Reading Frames><Organ><Oxygen Deficiency><P53><PBMC><PLA2-Interacting Protein><PLIP><Papillomavirus Transforming Protein E6><Pathway interactions><Patient Isolation><Patients><Peripheral Blood Mononuclear Cell><Phosphopeptides><Phosphoprotein P53><Phosphoprotein pp53><Phosphotransferase Gene><Phosphotransferases><Planocellular Carcinoma><Play><Primates><Primates Mammals><Programmed Cell Death><Protein Coding Region><Protein TP53><Proteins><Proto-Oncogenes><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Regulator Genes><Regulatory Protein><Research Training><Resistance><Ribonucleotide Reductase><Role><S Cervisiae Homolog of ESA1><S. Cervisiae Homolog of ESA1><Sampling><Science><Serine Phosphorylation Site><Short interfering RNA><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Small Interfering RNA><Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization><Spectroscopy, Mass, Matrix-Assisted Laser Desorption-Ionization><Squamous Carcinoma><Squamous Cell Epithelioma><Squamous cell carcinoma><Strains Cell Lines><T-Cell Lymphoma><T-Cell Non-Hodgkin's Lymphoma><T-Cell NonHodgkins Lymphoma><T-Cell and NK-Cell Non-Hodgkin's Lymphoma><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><TAT-Interacting Protein, 60-KD><TIP60><TP53><TP53 gene><TRP53><Taxes><Tissue Growth><Trans-Acting Factors><Trans-Activators><Transactivators><Transcription><Transcriptional Regulatory Elements><Transformed Cell Line><Transphosphorylases><Tumor Protein p53><Tumor Protein p53 Gene><Tumor Tissue><Tumor Viruses><Type I Human T-Lymphotropic Virus><UBE3A><UBE3A gene><Ubiquitin Ligase Component Gene><Ubiquitin Ligase Gene><Ubiquitin-Protein Ligase E3A><Uterine Cervix Cancer><Uterine Cervix Carcinoma><Viral><Viral Diseases><Viral Protein E6><Virus><Virus Diseases><Virus-HTLV-I><Virus-Related Malignancy><Virus-Related Malignant Neoplasm><Xenograft Model><affinity purification><aminoacid><anti-cancer therapeutic><anti-cancer therapy><anticancer therapeutic><anticancer therapy><biological signal transduction><c myc><c-ONC><c-myc Genes><cancer therapy><cancer-directed therapy><carcinogenesis><cell growth><cell immortalization><cmyc><cofactor><cultured cell line><experiment><experimental research><experimental study><experiments><genetic regulatory protein><global gene expression><global transcription profile><graduate student><high risk><human T cell lymphoma virus I><human T cell lymphoma virus type I><human T cell lymphotropic virus 1><human T cell lymphotropic virus type 1><human T lymphotropic virus I><human T-cell leukemia virus type 1><human model><human papilloma virus 16><human papillomavirus E6 oncoprotein><in vivo><insight><knock-down><knockdown><leukemia><mRNA><malignancy><matrix assisted laser desorption ionization><mitochondrial><model of human><neoplasm/cancer><neoplastic><nucleic acid sequence><oncogenic tumor virus><ontogeny><p53 Antigen><p53 Genes><p53 Tumor Suppressor><papilloma virus Transforming Protein E6><pathway><prevent><preventing><protein p53><protooncogene><regulatory gene><regulatory gene product><resistant><siRNA><social role><therapeutic target><thymus derived lymphocyte><training opportunity><trans acting element><transcriptome><transcriptome sequencing><transcriptomic sequencing><transforming virus><tumor><tumorigenesis><type 16 Human papilloma virus><type 16 Human papillomavirus><ubiquitin ligase><undergrad><undergraduate><undergraduate student><v-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog><viral associated cancer><viral associated malignancy><viral associated malignant neoplasm><viral carcinogenesis><viral induced cancer><viral induced malignancy><viral induced malignant neoplasm><viral infection><viral related cancer><viral related malignancy><viral related malignant neoplasm><virus associated cancer><virus associated malignancy><virus associated malignant neoplasm><virus induced cancer><virus induced malignancy><virus induced malignant neoplasm><virus infection><virus related cancer><virus-induced disease><wart virus><xenograft transplant model><xenotransplant model>
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Sun Hee Yim

TEXAS TECH UNIVERSITY, LUBBOCK, TX

Exploratory lead · 10/100
Solid budget
$444,573
FY 2022

Project Title

Protein Disulfide Bond Formation in the Reducing Environment of Cytoplasm

Grant Number:

1R15GM146198-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2022

End Date:

4/30/2026

Project Abstract

ABSTRACT Nearly every cellular process is controlled by thiol-based redox regulation. However, the mechanisms of targeted cysteine oxidation in the reducing environments of cytosol, mitochondria, and nucleus remain unclear. Hydrogen peroxide (H2O2) is known to induce oxidation of cysteines in protei...

Research Terms

<3-Selenylalanine><3-selenyl-L-alanine><ATP50 ATP synthase subunit><Academic Research Enhancement Awards><Address><Affinity><Aging><Alkylating Agents><Alkylators><Antibodies><Apoptosis><Apoptosis Pathway><Assay><Autoregulation><Binding><Binding Sites><Bioassay><Biochemical><Biologic Assays><Biologic Models><Biological Assay><Biological Markers><Biological Models><Biology><Blood Serum><Body Tissues><Cancers><Cardiovascular Diseases><Cell Communication and Signaling><Cell Culture System><Cell Function><Cell Nucleus><Cell Process><Cell Signaling><Cell physiology><Cellular Function><Cellular Physiology><Cellular Process><Cellular Regulation><Client><Co-Immunoprecipitations><Combining Site><Complex><Cysteine><Cytoplasm><Cytosol><Dehydrogenases><Diabetes Mellitus><Disease><Disorder><Disulfide Interchange Enzyme><Disulfide Isomerase><Disulfides><ERp59 PDI><Endoplasmic Reticulum><Environment><Ergastoplasm><Erp59><Eutheria><Event><Extracellular Space><GSBP><Glutathione><Glycosylation Site-Binding Protein><H2O2><Half-Cystine><Hemi-Myeloperoxidase><Homeostasis><Hydrogen Peroxide><Hydroperoxide><In Vitro><Intercellular Space><Intracellular Communication and Signaling><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><L-Cysteine><Malignant Neoplasms><Malignant Tumor><Mammalia><Mammals><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mercaptans><Mercapto Compounds><Methods><Mitochondria><Model System><Modeling><Modification><Molecular><Molecular Interaction><Myeloperoxidase><NIH><National Institutes of Health><Natural regeneration><Nature><Nucleus><Null Mouse><OSCP protein><Oxidants><Oxidation-Reduction><Oxidative Stress><Oxides><Oxidizing Agents><Oxidoreductase><Oxidoreductase Gene><Pathway interactions><Pattern><Peroxidases><Physiologic><Physiological><Physiological Homeostasis><Play><Programmed Cell Death><Property><Protein Disulfide Isomerase><Proteins><R15 Mechanism><R15 Program><Reactive Site><Reagent><Redox><Reducing Agents><Reductants><Reductases><Regeneration><Regulation><Regulatory Protein><Research><Role><S-S rearrangase><Selenocysteine><Serum><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Spermatids><Spermatoblasts><Spermatogenesis><Subcellular Process><Sulfhydryl Compounds><Sulfhydryl-Disulfide Interchange Enzyme><System><TRX gene><TRX protein><TRX1><TXN gene><Testicles><Testis><Texas><Thiol-Disulfide Transhydrogenase><Thiols><Thioredoxin><Tissues><Trypanothione-Glutathione Thioltransferase><United States National Institutes of Health><Universities><base><bio-markers><biologic marker><biological signal transduction><biomarker><cardiovascular disorder><catalase><cell growth regulation><cell type><comparative><complex V><data tools><diabetes><disulfide bond><dsbA Gene Product><dsbA Protein><dsbC Gene Product><dsbD Gene Product><electron acceptor><enzyme activity><extracellular><fundamental research><gamma-L-Glu-L-Cys-Gly><gamma-L-Glutamyl-L-Cysteinylglycine><genetic regulatory protein><glutathione peroxidase><human disease><in vivo><knock-out animal><knockout animal><malignancy><metabolome><metabonome><mitochondrial><mouse model><murine model><mutant><neoplasm/cancer><oligomycin sensitivity-conferring protein><oxidation><oxidation reduction reaction><pathway><peroxiredoxin><placental mammal><regenerate><regulatory gene product><response><social role><spermid><spermoblast><sulfhydryl group><undergrad><undergraduate><undergraduate student><xprA Gene Product>
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FENGWEI BAI

UNIVERSITY OF SOUTHERN MISSISSIPPI, HATTIESBURG, MS

Exploratory lead · 10/100
Solid budget
$444,000
FY 2023

Project Title

A novel live-attenuated Zika vaccine with a modified 5'UTR

Grant Number:

1R15AI178654-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/26/2023

End Date:

4/30/2026

Project Abstract

Summary Zika virus (ZIKV) is a mosquito-transmitted flavivirus that has caused devastating congenital Zika syndromes (CZS), including microcephaly, congenital malformation, and fetal demise in human newborns in the 2015 - 2016 epidemics. In addition, ZIKV infection can cause Guillain-Barré syndrome ...

Research Terms

<0-4 weeks old><21+ years old><3' Untranslated Regions><3'UTR><5' Untranslated Regions><5'UTR><AIDP><Acute Autoimmune Neuropathy><Acute Infective Polyneuritis><Acute Inflammatory Demyelinating Polyradiculoneuropathy><Acute Inflammatory Polyneuropathy><Acute Inflammatory Polyradiculoneuropathy><Adult><Adult Human><Affect><Alpha-Beta-Omega Interferon Receptor-1><American><Antibodies><Antiviral Protein Alpha Type><Attenuated><Attenuated Vaccines><Birth><Birth Defects><Body Tissues><Body Weight decreased><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><CNS Nervous System><Cambodian><Capsid><Categories><Cell Body><Cell Mediated Immunology><Cell-Mediated Immunity><Cells><Cellular Immunity><Central Nervous System><Cerebromeningitis><Clinical><Congenital Abnormality><Congenital Anatomic Abnormality><Congenital Anatomical Abnormality><Congenital Defects><Congenital Deformity><Congenital Malformation><Contracting Opportunities><Contracts><Culicidae><Data><Defect><Dose><Drops><Effectiveness><Encephalomeningitis><Enzyme Gene><Enzymes><Epidemic><Esteroproteases><Exhibits><Female><Flavivirus><Genetic Alteration><Genetic Change><Genetic defect><Genome><Gestation><Goals><Group B Arbovirus><Guillain Barré Syndrome><Guillaine-Barre Syndrome><HuIFN-Alpha-Rec><Human><Human Bites><IFNBR><IFRC><Immune><Immunes><Immunity><Immunization><Inactivated Vaccines><Inactivated Virus Vaccine><Interferon Alpha-Beta Receptor Alpha Chain><Killed Vaccines><Landry's paralysis><Landry-Guillain-Barre Syndrome><Live-attenuated Vaccine><Liver><Measures><Membrane><Meningoencephalitis><Mice><Mice Mammals><Microcephaly><Mississippi><Modern Man><Modification><Molecular><Mosquitoes><Murine><Mus><Mutation><Names><Nerve Cells><Nerve Unit><Neural Cell><Neuraxis><Neurocyte><Neurons><Newborn Infant><Newborns><Non-Polyadenylated RNA><Non-structural Protein><Nonstructural Protein><Nucleotides><ORFs><Open Reading Frames><Organ><Parturition><Pathogenesis><Pathogenicity><Peptidases><Peptide Hydrolases><Peripheral><Polyproteins><Pregnancy><Production><Protease Gene><Proteases><Protein Coding Region><Proteinases><Proteins><Proteolytic Enzymes><Public Health><RNA><RNA Gene Products><Research><Ribonucleic Acid><Safety><Spleen><Spleen Reticuloendothelial System><Structure><Subunit Vaccines><Survival Rate><T cell response><T8 Cells><T8 Lymphocytes><Teff cell><Testicles><Testis><Therapeutic><Time><Tissues><Translating><Translations><Transmission><Universities><Vaccines><Vagina><Vaginal><Vero Cells><Viral><Viral Burden><Viral Genome><Viral Load><Viral Load result><Viremia><Weight Loss><Weight Reduction><ZIKA><ZIKV><ZIKV disease><ZIKV infected><ZIKV infection><ZIKV positive><ZIKV vaccine><Zika Virus><Zika vaccine><Zika virus disease><Zika virus infection><Zika virus vaccine><access to vaccination><access to vaccines><acute idiopathic polyneuritis><acute post-infectious polyneuropathy><acute postinfectious polyneuropathy><adult youth><adulthood><antagonism><antagonist><assess effectiveness><attenuate><attenuates><attenuation><base><bases><body weight loss><congenital zika syndrome><congenital zika virus syndrome><congenital zikv syndrome><determine effectiveness><effectiveness assessment><effectiveness evaluation><effector T cell><evaluate effectiveness><examine effectiveness><fetal><fitness><future outbreak><genetic approach><genetic strategy><genome mutation><graduate student><hepatic body system><hepatic organ system><ifnar1 gene product><infected with ZIKV><infected with zika><insight><live vaccine><live vaccines><mRNA Leader Sequences><male><membrane structure><micrencephaly><microencephaly><mouse model><murine model><name><named><naming><neuronal><neurovirulence><new approaches><newborn child><newborn children><next outbreak><novel><novel approaches><novel strategies><novel strategy><postnatal><prevent><preventing><response><reverse genetics><safety assessment><training opportunity><translation><transmission process><type I IFN receptor><type I interferon receptor><undergrad><undergraduate><undergraduate student><vaccination access><vaccination availability><vaccine access><vaccine availability><vaccine candidate><viraemia><viral sepsis><virus genome><virusemia><wt-loss><young adult><young adulthood><zika disease><zika infected><zika infection><zika viral infection><zikav>
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Wei Li

MARSHALL UNIVERSITY, Huntington, WV

Exploratory lead · 10/100
Solid budget
$444,000
FY 2022

Project Title

Thymidine Phosphorylase: a Novel Target of Antiplatelet Therapy

Grant Number:

2R15HL145573-02

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/3/2019

End Date:

6/30/2025

Project Abstract

Project Summary/Abstract Platelet activation and aggregation is a major component of thrombosis, an underlying cause of myocardial infarction, ischemic stroke, and severe COVID-19, a new viral respiratory illness caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Various antipla...

Research Terms

<2019 novel corona virus><2019 novel coronavirus><2019-nCoV><2019-nCoV S protein><2019-nCoV spike glycoprotein><2019-nCoV spike protein><ACE2><ARDS><Accident and Emergency department><Acute Respiratory Distress><Acute Respiratory Distress Syndrome><Address><Adult ARDS><Adult RDS><Adult Respiratory Distress Syndrome><Agonist><Antiplatelet Agents><Antiplatelet Drugs><Antithrombotic Agents><Antithrombotic Drugs><Apoplexy><Atheroscleroses><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Attenuated><Autocrine Systems><Biology><Bleeding><Blood Coagulation Disorders><Blood Plasma><Blood Platelets><Brain Vascular Accident><C-reactive protein><COVID infected patient><COVID patient><COVID positive patient><COVID-19><COVID-19 S protein><COVID-19 associated death><COVID-19 associated fatality><COVID-19 associated mortality><COVID-19 death><COVID-19 fatality><COVID-19 induced death><COVID-19 induced fatality><COVID-19 induced mortality><COVID-19 infected patient><COVID-19 infection><COVID-19 mortality><COVID-19 patient><COVID-19 positive><COVID-19 positive patient><COVID-19 positivity><COVID-19 related death><COVID-19 related fatality><COVID-19 related mortality><COVID-19 spike glycoprotein><COVID-19 spike protein><COVID-19 therapy><COVID-19 treatment><COVID-19 virus><COVID19><COVID19 S protein><COVID19 associated death><COVID19 associated fatality><COVID19 associated mortality><COVID19 death><COVID19 fatality><COVID19 induced death><COVID19 induced fatality><COVID19 induced mortality><COVID19 infection><COVID19 mortality><COVID19 patient><COVID19 positive><COVID19 positive patient><COVID19 positivity><COVID19 related death><COVID19 related fatality><COVID19 related mortality><COVID19 spike glycoprotein><COVID19 spike protein><COVID19 therapy><COVID19 treatment><COVID19 virus><CV-19><CV19><Cancers><Cardiac infarction><Cell Communication and Signaling><Cell Signaling><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Chemicals><Clinical><CoV-2><CoV2><Coagulation Disorder><Coagulopathy><Collagen><Complex><Complication><Consumption Coagulopathy><Cytoplasm><Cytoplasmic Protein><Cytosol><D-dimer><D-dimer fibrin><D-dimer fragments><Da Nang Lung><Data><Development><Diabetes Mellitus><Dimerization><Disease><Disorder><Disseminated Intravascular Coagulation><Dose><Drug usage><Drugs><EC 1.1.1.27><Emergency Department><Emergency room><Event><FDA approved><Fibrin fragment D><Fibrinolytic Agents><Fibrinolytic Drugs><Future><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G Protein-Coupled Receptor Signaling><G-Protein-Coupled Receptors><G-Proteins><GPCR><GPCR Signaling><GTP-Binding Proteins><GTP-Regulatory Proteins><General Hospitals><Gliostatin><Goals><Guanine Nucleotide Coupling Protein><Guanine Nucleotide Regulatory Proteins><Hemorrhage><Hemostasis><Hemostatic function><Human><Individual><Inflammation><Inflammatory><Intracellular Communication and Signaling><Ischemic Stroke><L-Lactate Dehydrogenase><L-Lactic Acid Dehydrogenase><Lactate Dehydrogenase><Lead><Lentivirinae><Lentivirus><Life><Lung><Lung Respiratory System><MOF syndrome><Malignant Neoplasms><Malignant Tumor><Marrow platelet><Massachusetts><Mediating><Medication><Mice><Mice Mammals><Modern Man><Molecular><Multiple Organ Dysfunction Syndrome><Multiple Organ Failure><Murine><Mus><Myocardial Infarct><Myocardial Infarction><NAD-Lactate Dehydrogenase><PD-ECGF><Pathway interactions><Patients><Pb element><Pharmaceutic Preparations><Pharmaceutical Preparations><Pharmacology><Phosphorylase a><Plasma><Plasma Serum><Platelet Activation><Platelet Glycoproteins><Platelet aggregation><Platelet-Derived Endothelial Cell Growth Factor><Platelets><Play><Predictive Factor><Process><Protein Dimerization><Proteins><Proteins, specific or class, C-reactive><Reticuloendothelial System, Serum, Plasma><Risk><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 S protein><SARS-CoV-2 associated death><SARS-CoV-2 associated fatality><SARS-CoV-2 associated mortality><SARS-CoV-2 death><SARS-CoV-2 fatality><SARS-CoV-2 induced death><SARS-CoV-2 induced fatality><SARS-CoV-2 induced mortality><SARS-CoV-2 infected patient><SARS-CoV-2 infection><SARS-CoV-2 mortality><SARS-CoV-2 patient><SARS-CoV-2 positive><SARS-CoV-2 positive patient><SARS-CoV-2 positivity><SARS-CoV-2 related death><SARS-CoV-2 related fatality><SARS-CoV-2 related mortality><SARS-CoV-2 spike glycoprotein><SARS-CoV-2 spike protein><SARS-CoV-2 therapy><SARS-CoV-2 treatment><SARS-CoV2><SARS-CoV2 S protein><SARS-CoV2 infection><SARS-CoV2 spike glycoprotein><SARS-CoV2 spike protein><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><SH3 Domains><SRC Homology Region 3 Domain><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 S protein><Severe acute respiratory syndrome coronavirus 2 infection><Severe acute respiratory syndrome coronavirus 2 positive><Severe acute respiratory syndrome coronavirus 2 positivity><Severe acute respiratory syndrome coronavirus 2 spike glycoprotein><Severe acute respiratory syndrome coronavirus 2 spike protein><Severe acute respiratory syndrome related corona virus 2><Severity of illness><Shock Lung><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Stiff lung><Stroke><Systemic disease><TdRPase><Testing><Thrombase><Thrombin><Thrombocytes><Thrombocytopenia><Thrombolytic Agents><Thrombolytic Drugs><Thrombopenia><Thrombosis><Thrombus><Thymidine Phosphorylase><Transgenic Organisms><Viral><Virus><Virus-Lenti><Wuhan coronavirus><angiotensin converting enzyme 2><angiotensin converting enzyme II><antagonist><antithrombotic medication><antithrombotics><arrestin B><atheromatosis><atherosclerotic disease><atherosclerotic vascular disease><autocrine><beta-arrestin><biological signal transduction><bleeding disorder><blood loss><brain attack><cardiac infarct><cardiovascular risk><cardiovascular risk factor><cerebral vascular accident><cerebrovascular accident><clotting disorder><cohort><corona virus disease 2019><coronary attack><coronary infarct><coronary infarction><coronavirus disease 2019><coronavirus disease 2019 S protein><coronavirus disease 2019 associated death><coronavirus disease 2019 associated fatality><coronavirus disease 2019 associated mortality><coronavirus disease 2019 death><coronavirus disease 2019 fatality><coronavirus disease 2019 induced death><coronavirus disease 2019 induced fatality><coronavirus disease 2019 induced mortality><coronavirus disease 2019 infected patient><coronavirus disease 2019 infection><coronavirus disease 2019 mortality><coronavirus disease 2019 patient><coronavirus disease 2019 positive><coronavirus disease 2019 positive patient><coronavirus disease 2019 positivity><coronavirus disease 2019 related death><coronavirus disease 2019 related fatality><coronavirus disease 2019 related mortality><coronavirus disease 2019 spike glycoprotein><coronavirus disease 2019 spike protein><coronavirus disease 2019 therapy><coronavirus disease 2019 treatment><coronavirus disease 2019 virus><coronavirus disease infected patient><coronavirus disease patient><coronavirus disease positive patient><coronavirus disease-19><coronavirus disease-19 mortality><coronavirus disease-19 patient><coronavirus disease-19 virus><coronavirus infectious disease-19><coronavirus patient><cremaster muscle><cytokine release syndrome><cytokine storm><death due to COVID-19><death due to COVID19><death due to SARS-CoV-2><death due to coronavirus disease 2019><death due to severe acute respiratory syndrome coronavirus 2><death in COVID><death in COVID-19><death in SARS-CoV-2><death in coronavirus disease><death in coronavirus disease 2019><death in severe acute respiratory syndrome coronavirus 2><desensitization><developmental><diabetes><disease severity><drug use><drug/agent><fatality due to COVID-19><fatality due to COVID19><fatality due to SARS-CoV-2><fatality due to coronavirus disease 2019><fatality due to severe acute respiratory syndrome coronavirus 2><fibrin fragment D-dimer><fibrin fragment D1 dimer><fibrin fragment DD><fibrinogenase><hCoV19><heart attack><heart infarct><heart infarction><heavy metal Pb><heavy metal lead><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><inhibitor><insight><lactic acid dehydrogenase><life-threatening COVID><life-threatening COVID-19><life-threatening SARS-CoV-2><life-threatening coronavirus disease><life-threatening coronavirus disease 2019><life-threatening severe acute respiratory syndrome coronavirus 2><malignancy><mortality><mortality due to COVID-19><mortality due to COVID19><mortality due to SARS-CoV-2><mortality due to coronavirus disease 2019><mortality due to severe acute respiratory syndrome coronavirus 2><mouse model><multiorgan failure><multiple organ system failure><murine model><nCoV2><neoplasm/cancer><novel><pandemic><pandemic disease><paracrine><pathway><patient infected with COVID><patient infected with COVID-19><patient infected with SARS-CoV-2><patient infected with coronavirus disease><patient infected with coronavirus disease 2019><patient infected with severe acute respiratory syndrome coronavirus 2><patient with COVID><patient with COVID-19><patient with COVID19><patient with SARS-CoV-2><patient with coronavirus disease><patient with coronavirus disease 2019><patient with severe acute respiratory distress syndrome coronavirus 2><platelet function><prevent><preventing><pulmonary><pulmonary symptom><recruit><respiratory><serious COVID><serious COVID-19><serious SARS-CoV-2><serious coronavirus disease><serious coronavirus disease 2019><serious severe acute respiratory syndrome coronavirus 2><severe COVID><severe COVID-19><severe COVID19><severe SARS-CoV-2><severe acute respiratory syndrome coronavirus 2 associated death><severe acute respiratory syndrome coronavirus 2 associated fatality><severe acute respiratory syndrome coronavirus 2 associated mortality><severe acute respiratory syndrome coronavirus 2 death><severe acute respiratory syndrome coronavirus 2 fatality><severe acute respiratory syndrome coronavirus 2 induced death><severe acute respiratory syndrome coronavirus 2 induced fatality><severe acute respiratory syndrome coronavirus 2 induced mortality><severe acute respiratory syndrome coronavirus 2 infected patient><severe acute respiratory syndrome coronavirus 2 mortality><severe acute respiratory syndrome coronavirus 2 patient><severe acute respiratory syndrome coronavirus 2 positive patient><severe acute respiratory syndrome coronavirus 2 related death><severe acute respiratory syndrome coronavirus 2 related fatality><severe acute respiratory syndrome coronavirus 2 related mortality><severe acute respiratory syndrome coronavirus 2 therapy><severe acute respiratory syndrome coronavirus 2 treatment><severe coronavirus disease><severe coronavirus disease 19><severe coronavirus disease 2019><severe severe acute respiratory syndrome coronavirus 2><side effect><social role><src Kinases><src Protein-Tyrosine Kinases><src Tyrosine Kinases><src-Family Kinases><src-Family Tyrosine Kinases><thrombotic><thrombotic disease><thrombotic disorder><transgenic><treat COVID-19><treat COVID19><treat SARS-CoV-2><treat coronavirus disease 2019><treat severe acute respiratory syndrome coronavirus 2><wet lung><β-arrestin>
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Costel C. Darie

CLARKSON UNIVERSITY, POTSDAM, NY

Exploratory lead · 10/100
Solid budget
$443,330
FY 2022

Project Title

Identifying a proteomic signature for breast cancer detection in breast milk and serum

Grant Number:

1R15CA260126-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/22/2021

End Date:

5/31/2025

Project Abstract

Program Director/Principal Investigator (Last, First, Middle): Darie, Costel C. Project summary The R15 AREA is designed to support small scale research projects at primarily undergraduate institutions that provide bachelors and advanced degrees and that do not have major support from NIH. Our R15 ...

Research Terms

<A1PI><Address><Age><Area><Bio-Informatics><Biochemical><Biochemical Pathway><Bioinformatics><Biological><Biomedical Research><Blood><Blood Reticuloendothelial System><Blood Serum><Body Tissues><Breast><Breast Cancer><Breast Cancer Detection><Breast Cancer Prevention><Breast Cancer Risk Factor><Breast Invasive Ductal Carcinoma><Breast Milk><Breast cancer screening><Breast screening><Breastmilk><Cancers><Caseins><Collection><Complement><Complement Proteins><Computer software><Development><Diagnosis><Diagnostic><EC 1.1.1.27><EC 2.3.1.85><ELISA><Early Diagnosis><Early Intervention><Early treatment><Environment><Enzyme-Linked Immunosorbent Assay><Epidemiologic Research><Epidemiologic Studies><Epidemiological Studies><Epidemiology Research><Fatty Acid Synthetase Complex><Fatty-acid synthase><Female Groups><Generalized Growth><Genes><Genets><Glycoproteins><Goals><Grant><Growth><HLA-DR Associated Protein II><Health><Human Milk><Human Mother's Milk><IGAAD><Individual><Inhibitor of GZMA-Activated DNase><Institution><Isotopes><L-Lactate Dehydrogenase><L-Lactic Acid Dehydrogenase><Lactate Dehydrogenase><Lactoferrin><Lactotransferrin><Lead><Lipase><Liquid substance><Location><Malignant Neoplasms><Malignant Tumor><Mammary Gland Milk><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Measures><Medical Research><Metabolic Networks><Methods><Milk><Milk Proteins><Mother's Milk><NAD+ oxidoreductase Xanthine><NAD-Lactate Dehydrogenase><NIH><National Institutes of Health><Network Analysis><Ontology><Organ><Organism><Outcome><Oxidases><Pathologic><Pathway Analysis><Pathway interactions><Pb element><Peptides><Phosphatase 2A Inhibitor I2PP2A><Plug-in><Population><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Pre-Menopause><Pre-menopausal Period><Premenopausal><Premenopausal Period><Premenopause><Preventative treatment><Preventive treatment><Primary Prevention><Principal Investigator><Process><Protein Modification><Proteins><Proteomics><Purine Hydroxylase I><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Grants><Research Project Grants><Research Projects><Risk><Role><SET Translocation Inhibitor-2 of Protein Phosphatase-2A><Sampling><Serum><Serum Proteins><Set protein><Software><Source><Template Activating Factor I Beta><Tissue Growth><Tissues><Training><Translations><Triacylglycerol Hydrolase><Triacylglycerol Lipase><Triacylglycerol acylhydrolase><Tributyrinase><Triglyceridase><Triglyceride Lipase><Triolean Hydrolase><United States National Institutes of Health><Universities><Woman><Women's Group><Work><XDH><XDH gene><Xanthine Dehydrogenase><Xanthine Dehydrogenase Gene><Xanthine Oxidoreductase><Zinc><Zn element><adolescent woman><adolescent women><ages><alpha 1 Antiprotease><alpha 1-Antichymotrypsin><alpha 1-Antiproteinase><alpha 1-Antitrypsin><alpha 1-Antitrypsin Trypsin Inhibitor><alpha 1-Protease Inhibitor><alpha 1-Proteinase Inhibitor><base><bile salts><biologic><biomarker discovery><biomarker signature><breast cancer progression><breast cancer risk><breast infiltrating ductal carcinoma><cancer diagnosis><candidate biomarker><candidate marker><career><chymotrypsin><comparator group><comparison group><design><designing><developmental><ductal breast carcinoma><early detection><early therapy><enzyme linked immunoassay><epidemiologic investigation><epidemiology study><fluid><heavy metal Pb><heavy metal lead><infiltrating duct carcinoma><infiltrating ductal adenocarcinoma><infiltrating ductal carcinoma><interest><invasive ductal adenocarcinoma><invasive ductal carcinoma><lactic acid dehydrogenase><liquid><living system><malignancy><malignant breast neoplasm><malignant breast tumor><mammary cancer detection><mammary cancer prevention><mammary screening><mammary tumor prevention><maternal milk><metabolism measurement><metabolomics><metabonomics><mortality><neoplasm/cancer><ontogeny><pandemic><pandemic disease><parity><pathway><pre-menopausal><prevent breast cancer><programs><protein biomarkers><protein markers><protein protein interaction><proteomic signature><public health relevance><reproductive><sample archive><social role><tool><transcriptomics><tributyrase><undergrad><undergraduate><undergraduate student><web site><website><young woman><α1-Antitrypsin><α1-Proteinase Inhibitor>
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PIERRE K ALEXANDRE

FLORIDA ATLANTIC UNIVERSITY, BOCA RATON, FL

Exploratory lead · 10/100
Solid budget
$437,274
FY 2023

Project Title

Use of electronic health records in underserved communities in Florida

Grant Number:

1R15HD110923-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/5/2023

End Date:

3/31/2026

Project Abstract

The Center for Medicare and Medicaid Services (CMS) has acknowledged its commitment to promoting widespread Meaningful Use (MU) of Electronic Health Records (EHRs) through over $30 billion investment of funds from the Health Information Technology for Economic and Clinical Health (HITECH) Act of 200...

Research Terms

<Academic Research Enhancement Awards><Address><Adopted><Adoption><American><Area><Centers for Medicare and Medicaid Services><Certification><Clinical><Clinical Data><Communication><Communities><Continuity of Care><Continuity of Patient Care><Continuum of Care><Cost Containment><Cost Control><County><Data><Data Bases><Data Set><Data Sources><Databases><Dependence><Digit><Digit structure><Disparities><Disparity><Disparity population><Economics><Electronic Health Record><Electronics><Eligibility><Eligibility Determination><Environment><Estimation Techniques><Ethnic Origin><Ethnicity><Exposure to><Faculty><Florida><Funding><Goals><Health><Health Benefit><Health Care Financing Administration><Health Resources><Healthcare><Heterogeneity><History><Incentives><Insurance><Intervention><Intervention Strategies><Investments><Journals><Linear Models><Link><Literature><Logistics><Low income><Magazine><Measures><Medicaid><Medical><Methods><Modeling><NIH><National Institutes of Health><Out-patients><Outcome><Outpatients><Participant><Patients><Peer Review><Policies><Policy Maker><Population><Printing><Process><Protocol Screening><Provider><Public Health><R15 Mechanism><R15 Program><Race><Races><Racial Equity><Recording of previous events><Records><Recovery><Regulation><Reporting><Research><Research Resources><Resources><Retrospective cohort study><SES disparity><Safety><Specialty><Strategic Planning><System><Technology><Training><Underserved Population><United States><United States Centers for Medicare and Medicaid Services><United States Health Care Financing Administration><United States National Institutes of Health><Vulnerable Populations><beneficiary><co-morbid><co-morbidity><comorbidity><data base><depository><design><designing><digital><disadvantaged group><disadvantaged individual><disadvantaged people><disadvantaged population><disadvantaged subgroup><disparities across groups><disparity across subgroups><disparity among groups><disparity among subgroups><disparity between groups><disparity between subgroups><disparity in health><economic><electronic><electronic device><electronic health care record><electronic health information><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><empowerment><ethnic minority><experience><geographic disadvantage><geographic disparity><geographic inequality><geographic inequity><geographic location disparity><graduate student><group disparity><group inequality><group inequity><health administration><health assessment><health care><health disparity><health equity><health information technology><histories><improved><incentive program><incentive-based program><inequalities among populations><inequalities between populations><inequalities in populations><inequality across populations><inequality among groups><inequality between groups><inequality in groups><inequities among populations><inequities between populations><inequities in populations><inequity across groups><inequity across populations><inequity between groups><inequity in groups><inner city><innovate><innovation><innovative><insight><interoperability><interventional strategy><medical specialties><member><payment><population health><population inequality><population inequity><power analysis><programs><public health relevance><racial><racial background><racial minority><racial origin><repository><rural area><rural location><rural region><socio-economic><socio-economic disparity><socio-economic inequality><socio-economic inequity><socio-economically><socioeconomic disparity><socioeconomic inequality><socioeconomic inequity><socioeconomically><socioeconomics><subgroup disparity><theories><under served community><under served group><under served individual><under served people><under served population><undergrad><undergraduate><undergraduate student><underserved community><underserved group><underserved individual><underserved people><unequal group><unequal population><uptake><vulnerable group><vulnerable individual><vulnerable people>
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Kartik Balachandran

UNIVERSITY OF ARKANSAS AT FAYETTEVILLE, FAYETTEVILLE, AR

Exploratory lead · 10/100
Solid budget
$436,642
FY 2022

Project Title

ACE2 SARS-CoV2-mediated valve disease in a microphysiological tissue-chip model

Grant Number:

1R15AI169564-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

2/28/2026

Project Abstract

PROJECT SUMMARY Recent reports have uncovered the role of angiotensin-converting enzyme 2 (ACE2) as the receptor for mediating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) entry into host cells. The aortic valve is one specific tissue within the cardiovascular system that has robust ...

Research Terms

<2019 novel corona virus><2019 novel coronavirus><2019-nCoV><2019-nCoV S protein><2019-nCoV spike glycoprotein><2019-nCoV spike protein><3-D><3-Dimensional><3D><ACE2><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Amino Acids><Aortic valvular disorders><Arkansas><Arrhythmia><Biomedical Research><Body Tissues><COVID infected patient><COVID patient><COVID positive patient><COVID-19><COVID-19 S protein><COVID-19 infected patient><COVID-19 infection><COVID-19 patient><COVID-19 positive patient><COVID-19 spike glycoprotein><COVID-19 spike protein><COVID-19 virus><COVID19><COVID19 S protein><COVID19 infection><COVID19 patient><COVID19 positive patient><COVID19 spike glycoprotein><COVID19 spike protein><COVID19 virus><CV-19><CV19><Calcified><Cardiac Arrhythmia><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell Survival><Cell Viability><Cell-Extracellular Matrix><Cells><Clinical><CoV-2><CoV2><Collagen><Development><Disease><Disease Progression><Disorder><ECM><Education><Educational aspects><Endothelial Cells><Engineering><Ensure><Environment><Enzyme Gene><Enzymes><Exposure to><Extracellular Matrix><Family suidae><Fibroblasts><Future><Glycosaminoglycans><Grant><HIV><Heart Arrhythmias><Heart Muscle Cells><Heart Vascular><Heart myocyte><Histology><Human><Human Immunodeficiency Viruses><Human Resources><Hydrogels><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><In Situ Hybridization><In Vitro><Infection><Inflammation><Inflammatory><Institution><Intracellular Communication and Signaling><LAV-HTLV-III><Laboratories><Lymphadenopathy-Associated Virus><Manpower><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mechanics><Mediating><Mediator><Mediator of Activation><Mediator of activation protein><Minority-Serving Institution><Modeling><Modern Man><Mucopolysaccharides><Myocarditis><Pathologic><Pathology><Patients><Phenotype><Physiologic><Physiological><Physiology><Pigs><Population><Preclinical Testing><Predisposition><Probability><Proteomics><Receptor Protein><Renin-Angiotensin System><Reporting><Research><Respiratory Failure><Role><SARS Virus><SARS corona virus><SARS corona virus 2><SARS coronavirus><SARS-Associated Coronavirus><SARS-CO-V2><SARS-COVID-2><SARS-CoV><SARS-CoV-1><SARS-CoV-2><SARS-CoV-2 S protein><SARS-CoV-2 infected patient><SARS-CoV-2 infection><SARS-CoV-2 patient><SARS-CoV-2 positive patient><SARS-CoV-2 spike glycoprotein><SARS-CoV-2 spike protein><SARS-CoV2><SARS-CoV2 S protein><SARS-CoV2 infection><SARS-CoV2 spike glycoprotein><SARS-CoV2 spike protein><SARS-Related Coronavirus><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Sampling><Sclerosis><Severe Acute Respiratory Coronavirus><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome Virus><Severe Acute Respiratory Syndrome corona virus><Severe Acute Respiratory Syndrome coronavirus><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 S protein><Severe acute respiratory syndrome coronavirus 2 infection><Severe acute respiratory syndrome coronavirus 2 spike glycoprotein><Severe acute respiratory syndrome coronavirus 2 spike protein><Severe acute respiratory syndrome related corona virus 2><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Structure><Student recruitment><Students><Suidae><Susceptibility><Swine><System><Techniques><Testing><Therapeutic><Tissue Arrays><Tissue Banks><Tissue Chip><Tissue Collection><Tissue Microarray><Tissue repository><Tissues><Training Programs><Underrepresented Students><Universities><Validation><Viral Burden><Viral Load><Viral Load result><Virus-HIV><Work><Wuhan coronavirus><aminoacid><angiotensin converting enzyme 2><angiotensin converting enzyme II><aortic valve><aortic valve defect><aortic valve disease><aortic valve disorder><aortic valvular disease><base><biological signal transduction><calcification><cardiac inflammation><cardiomyocyte><career><circulatory system><co-morbid><co-morbidity><comorbidity><corona virus disease 2019><coronavirus disease 2019><coronavirus disease 2019 S protein><coronavirus disease 2019 infected patient><coronavirus disease 2019 infection><coronavirus disease 2019 patient><coronavirus disease 2019 positive patient><coronavirus disease 2019 spike glycoprotein><coronavirus disease 2019 spike protein><coronavirus disease 2019 virus><coronavirus disease infected patient><coronavirus disease patient><coronavirus disease positive patient><coronavirus disease-19><coronavirus disease-19 patient><coronavirus disease-19 virus><coronavirus infectious disease-19><coronavirus patient><cytokine><cytokine release syndrome><cytokine storm><design><designing><developmental><efficacy testing><experience><experiment><experimental research><experimental study><hCoV19><hemodynamics><histologic stains><histological stains><human disease><in situ Hybridization Genetics><in situ Hybridization Staining Method><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><innovate><innovation><innovative><interstitial cell><life-threatening COVID><life-threatening COVID-19><life-threatening SARS-CoV-2><life-threatening coronavirus disease><life-threatening coronavirus disease 2019><life-threatening severe acute respiratory syndrome coronavirus 2><lung failure><mechanical><minority institution><mortality><nCoV2><novel><patient infected with COVID><patient infected with COVID-19><patient infected with SARS-CoV-2><patient infected with coronavirus disease><patient infected with coronavirus disease 2019><patient infected with severe acute respiratory syndrome coronavirus 2><patient with COVID><patient with COVID-19><patient with COVID19><patient with SARS-CoV-2><patient with coronavirus disease><patient with coronavirus disease 2019><patient with severe acute respiratory distress syndrome coronavirus 2><personnel><porcine><pre-clinical testing><prototype><pulmonary failure><receptor><serious COVID><serious COVID-19><serious SARS-CoV-2><serious coronavirus disease><serious coronavirus disease 2019><serious severe acute respiratory syndrome coronavirus 2><severe COVID><severe COVID-19><severe COVID19><severe SARS-CoV-2><severe acute respiratory syndrome coronavirus 2 infected patient><severe acute respiratory syndrome coronavirus 2 patient><severe acute respiratory syndrome coronavirus 2 positive patient><severe acute respiratory syndrome-CoV><severe coronavirus disease><severe coronavirus disease 19><severe coronavirus disease 2019><severe severe acute respiratory syndrome coronavirus 2><social role><success><suid><three dimensional><undergrad><undergraduate><undergraduate research><undergraduate student><viron>
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Jigna Morarji Dharod

UNIVERSITY OF NORTH CAROLINA GREENSBORO, GREENSBORO, NC

Exploratory lead · 10/100
Solid budget
$436,500
FY 2022

Project Title

Cross-generational effect of food insecurity: Understanding the relationship between food insecurity and breastfeeding behaviors.

Grant Number:

2R15HD095261-02A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2019

End Date:

3/31/2026

Project Abstract

Project Summary The American Academy of Pediatrics recommend exclusive breastfeeding for the first 6 months of life. Breastmilk protects infants from infectious and chronic diseases both in the short term and later in life. Especially, breastfeeding ensures security and optimal nutrition for infants...

Research Terms

<4-O-beta-D-galactopyranosyl-D-glucose><Academy><Address><Aeroseb-HC><Affect><African American><Afro American><Afroamerican><Age><American><Anxiety><Behavior><Biological Markers><Birth><Breast Feeding><Breast Milk><Breast fed><Breastfed><Breastfeeding><Breastmilk><Cardiac Diseases><Cardiac Disorders><Cetacort><Chronic><Chronic Disease><Chronic Illness><Clinic><Cohort Effect><Communicable Diseases><Cort-Dome><Cortef><Cortenema><Cortisol><Cortispray><Cortril><Country><Data><Decrease health disparities><Dermacort><Discipline of Nursing><Eating><Eldecort><Ensure><Equipment and supply inventories><Exclusive Breast Feeding><Exclusive Breastfeeding><Feeding Patterns><Female Groups><Food><Food Intake><Food Supply><Food or Food Product><Frequencies><Generation Effect><Generations><Goals><Growth and Development><Growth and Development function><Health disparity mitigation><Health disparity reduction><Heart Diseases><Hispanic><Home><Home visitation><Hospitals><Hour><House Call><Household><Human Milk><Human Mother's Milk><Hydrocortisone><Hydrocortone><Hytone><Infant><Infant Food><Infectious Disease Pathway><Infectious Diseases><Infectious Disorder><Interview><Inventory><Lactose><Life><Low income><Lower health disparities><Mammary Gland Milk><Mammary gland><Measures><Metabolic Diseases><Metabolic Disorder><Milk><Mitigate health disparities><Mother's Milk><Mothers><Na element><Nursing><Nursing Field><Nursing Profession><Nutracort><Participant><Parturition><Pattern><Pediatrics><Persons><Postpartum><Postpartum Period><Pregnant Women><Proctocort><Production><Proteins><Public Health><Pump><Reduce health disparities><Research><Research Support><Research Training><Risk Estimate><Risk Factors><Role><S-nitro-N-acetylpenicillamine><SNAP><Sampling><Secure><Security><Self Efficacy><Sleep Disorders><Social support><Sodium><Stress><Thesaurismosis><Time><Underrepresented Students><Visit><Woman><Women's Group><ages><baby food><bio-markers><biologic marker><biomarker><breast pump><child adiposity><child obesity><childhood adiposity><childhood obesity><chronic disorder><constriction><disparity in health><exclusively breast fed><exclusively breast feeding><exclusively breastfed><exclusively breastfeeding><expectant mother><expecting mother><experience><federal poverty level><feeding><food insecurity><food security><food shortage><health disparity><heart disorder><home visit><infant nutrition><lower income families><maternal milk><maternal stress><metabolism disorder><milk production><obese children><obesity during childhood><obesity in children><pediatric obesity><perceived stress><perception of stress><post-partum><pregnant mothers><prenatal><produce milk><recruit><self-reported stress><sleep diseases><sleep dysfunction><sleep illness><sleep problem><social cognitive theory><social learning theory><social role><social support network><socio-demographic variables><socio-demographics><sociodemographic variables><sociodemographics><stress perception><stressed mothers><tool><unborn>
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KRISTEN G ANDERSON

REED COLLEGE, PORTLAND, OR

Exploratory lead · 10/100
Solid budget
$427,553
FY 2022

Project Title

The impact of gender on alcohol use in peer drinking contexts

Grant Number:

1R15AA029524-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/7/2022

End Date:

7/31/2025

Project Abstract

PROJECT TITLE: The impact of gender on alcohol use in peer drinking contexts PROJECT SUMMARY/ABSTRACT The aim of this mixed-methods research is to examine the impact of gender identification and group dynamics on alcohol-related decision making in peer social contexts for emerging adults. While alc...

Research Terms

<Academic Research Enhancement Awards><Age><Alcohol Chemical Class><Alcohol Drinking><Alcohol abuse><Alcohol consumption><Alcohols><Award><Behavioral><Biology><Birth><Communities><Consumption><Decision Making><Development><Eating><EtOH abuse><EtOH drinking><EtOH use><Feeling suicidal><Female><Feminine><Food><Food Intake><Food or Food Product><Gender><Gender Identity><Human><Individual><Institution><Interview><Intoxication><Investigation><Location><Masculine><Measures><Methodology><Methods><Modeling><Modern Man><NIH><National Institutes of Health><Participant><Parturition><Patient Self-Report><Pattern><Persons><Population><Preventative strategy><Prevention strategy><Preventive strategy><Process><R15 Mechanism><R15 Program><Reporting><Research><Research Methodology><Research Methods><Risk><Sampling><Self-Report><Social Characteristics><Social Environment><Social Identification><Social Identity><Standardization><Structure><Suicidal thoughts><Techniques><Time><United States National Institutes of Health><Woman><Work><Youth><Youth 10-21><age group><ages><alcohol and other drug><alcohol co-abuse><alcohol consequences><alcohol ingestion><alcohol intake><alcohol involvement><alcohol problem><alcohol product use><alcohol related consequences><alcohol use><alcoholic beverage consumption><alcoholic drink intake><at-risk drinking><base><binge alcohol consumption><binge drinking><cis-gender><cisgender><cognitive assessment><cognitive testing><college><collegiate><design><designing><developmental><digital><disparity in health><drinking><drinking behavior><early adulthood><emerging adult><emerging adulthood><episodic drinking><ethanol abuse><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><experience><gender diversity><hazardous alcohol use><hazardous drinking><health disparity><high risk><high risk drinking><involvement with alcohol><male><marginalized group><marginalized individual><marginalized people><marginalized population><men><men's><non-alcoholic><nonalcoholic><peer><prevent><preventing><problem alcohol use><problem drinking><problematic alcohol consumption><problematic alcohol use><recruit><risky drinking><sex><simulation><social><social climate><social context><socioenvironment><socioenvironmental><suicidal ideation><suicidal thinking><suicide ideation><thoughts about suicide><transfeminine><transmasculine><undergrad><undergraduate><undergraduate student><willingness>
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Christopher George Lorenz Vecsey

SKIDMORE COLLEGE, SARATOGA SPRINGS, NY

Exploratory lead · 10/100
Solid budget
$427,433
FY 2022

Project Title

Investigation of Neuropeptide Signaling Mechanisms that Control Sleep

Grant Number:

2R15NS101692-02A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2021

End Date:

11/30/2025

Project Abstract

Sleep disturbances are increasingly common and are associated with a variety of comorbidities and other public health consequences. It is therefore critical to improve our understanding of the neural mechanisms that control the timing and quality of sleep. Key signaling molecules that regulate sleep...

Research Terms

<3'5'-cyclic ester of AMP><Accidents><Acute><Address><Adenosine Cyclic 3',5'-Monophosphate><Adenosine Cyclic Monophosphate><Adenosine, cyclic 3',5'-(hydrogen phosphate)><Animals><Award><Behavior><Behavioral><Biomedical Research><Brain><Brain Nervous System><Calcium><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cellular Neurobiology><Cyclic AMP><Dangerousness><Development><Drosophila><Drosophila genus><Drosophila melanogaster><Drug Therapy><Encephalon><Event><Family><Feeding behaviors><Flies><Future><Genetic><Genetic Technics><Genetic Techniques><Goals><Health><Hour><Human><Individual><Ingestive Behavior><Intracellular Communication and Signaling><Investigation><Knowledge><Light><Mammalia><Mammals><Manuscripts><Modern Man><Modernization><Molecular><Molecular Neurobiology><Nature><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neuropeptide Tyrosine><Neuropeptides><Neurosciences Research><Output><Peptides><Performance at work><Pharmacogenetics><Pharmacology><Pharmacotherapy><Photoradiation><Play><Population><Property><Public Health><Publishing><QOL><Quality of life><Research><Research Resources><Resources><Role><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Sleep><Sleep Deprivation><Sleep disturbances><Speed><Students><System><Testing><Training><Wakefulness><Work><aberrant sleep><adenosine 3'5' monophosphate><base><biological signal transduction><cAMP><career><circadian><co-morbid><co-morbidity><comorbidity><conference><convention><cost><deficient sleep><design><designing><developmental><disrupted sleep><disturbed sleep><drug treatment><effective therapy><effective treatment><experience><experiment><experimental research><experimental study><feeding-related behaviors><fluorescence imaging><fluorescent imaging><fly><fruit fly><gene manipulation><genetic approach><genetic manipulation><genetic strategy><genetically manipulate><genetically perturb><imaging capabilities><impaired sleep><improved><inadequate sleep><insight><insufficient sleep><irregular sleep><job performance><neural circuit><neural circuitry><neural mechanism><neurocircuitry><neuromechanism><neuronal><neuropeptide F><neuropeptide Y><nutrient intake activity><optogenetics><prevent><preventing><quality of sleep><response><side effect><sleep abnormalities><sleep behavior><sleep control><sleep debt><sleep deficiency><sleep deficit><sleep disruption><sleep dysregulation><sleep habit><sleep insufficiency><sleep loss><sleep pattern><sleep quality><sleep regulation><social role><summit><symposia><symposium><synaptic circuit><synaptic circuitry><undergrad><undergraduate><undergraduate student><work performance>
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SUSAN L. BROWN

BOWLING GREEN STATE UNIVERSITY, BOWLING GREEN, OH

Exploratory lead · 10/100
Solid budget
$426,000
FY 2023

Project Title

Health and Well-being Effects on Later-life Divorce and Subsequent Repartnering

Grant Number:

2R15AG047588-03A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2014

End Date:

3/31/2026

Project Abstract

Health and Well-being Effects on Later-life Divorce and Subsequent Repartnering R15 Renewal Application Abstract Susan L. Brown and I-Fen Lin, MPIs The gray divorce rate, which is the rate of divorce among those aged 50 and older, doubled between 1990 and 2010, rising from 5 to 10 divorcing persons ...

Research Terms

<21+ years old><Accounting><Address><Adult><Adult Human><Age><Aging><Automobile Driving><Chronic><Compensation><Convalescence><Coping Skills><Data><Dimensions><Divorce><Divorced state><Economics><Elderly><Emotional Depression><Environment><Exposure to><Friends><Gender><Generalized Growth><Goals><Grant><Growth><Health><Health Benefit><Health and Retirement Study><Individual><Life Cycle><Life Cycle Stages><Literature><Married Persons><Mental Health><Mental Hygiene><Modality><Modeling><Outcome><Pattern><Personal Satisfaction><Persons><Population Heterogeneity><Prevalence><Process><Psychological Health><Public Health><Publishing><Recovery><Research><Research Assistant><Research Resources><Resources><Risk><Role><Security><Shapes><Social support><Speed><Spouses><Strategic Planning><Stress><Students><Tissue Growth><Training><Unmarried><Woman><Work><adulthood><advanced age><age group><aged><ages><coping strategy><depression symptom><depressive><depressive symptoms><diverse populations><driving><economic><elders><experience><geriatric><heterogeneous population><improved><late life><later life><life course><meeting><meetings><men><older adult><older men><older person><older women><ontogeny><physical conditioning><physical health><population diversity><prospective><response><senior citizen><social><social role><social support network><stem><support network><undergrad><undergraduate><undergraduate student><well-being><wellbeing>
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Lizabeth A Allison

COLLEGE OF WILLIAM AND MARY, WILLIAMSBURG, VA

Exploratory lead · 10/100
Solid budget
$425,824
FY 2022

Project Title

Thyroid Hormone Receptor Mislocalization and Pathogenesis

Grant Number:

2R15DK058028-06

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2001

End Date:

5/31/2025

Project Abstract

PROJECT SUMMARY Thyroid hormone receptors (TRs) are essential transcription factors that either activate or repress the expression of target genes in response to thyroid hormone (T3). The proposed research explores a novel facet of our overarching hypothesis that mislocalization of TR contributes to...

Research Terms

<APF-1><ATP-Dependent Proteolysis Factor 1><Acetylation><Acetyltransferase><Address><Affect><Assay><Basal Transcription Factor><Basal transcription factor genes><Binding Proteins><Bioassay><Biologic Assays><Biological Assay><Cell Body><Cell Communication and Signaling><Cell Nucleus><Cell Signaling><Cells><Complex><Cytoplasm><Data><Deacetylase><Degradation Pathway><Degradative Pathway><Destinations><Development><Endocrine Diseases><Endocrine Diseases and Manifestations><Endocrine System Diseases><Ensure><Exportins><Fluorescence Light Microscopy><Fluorescence Microscopy><Fluorescence Photobleaching Recovery><Fluorescence Recovery After Photobleaching><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic Alteration><Genetic Change><Genetic Transcription><Genetic defect><HMG-20><Health><High Mobility Protein 20><Human><Impairment><Importins><Intermediary Metabolism><Intracellular Communication and Signaling><Ligand Binding Protein><Ligand Binding Protein Gene><Ligands><Link><Luciferase Immunologic><Luciferases><Mammalian Cell><Measurement><Measures><Mediating><Metabolic Processes><Metabolism><Modeling><Modern Man><Modification><Molecular><Mutation><NLS Peptide><Nuclear><Nuclear Export><Nuclear Localization Signal><Nuclear Localization Signal Peptide><Nucleus><Output><Pathogenesis><Pathway interactions><Pharmacology><Pilot Projects><Plasmids><Play><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Process><Protein Binding><Protein Hormone Receptor><Protein Modification><Proteins><Publications><Publishing><RNA Expression><Regulatory Protein><Reporter><Reporter Genes><Reporting><Research><Resistance><Role><Scientific Publication><Signal Transduction><Signal Transduction Systems><Signaling><Site><Students><Syndrome><Talents><Testing><Thyroid Gland Hormone><Thyroid Hormone Receptor><Thyroid Hormones><Time><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transfection><Ubiquitilation><Ubiquitin><Ubiquitination><Ubiquitinoylation><base><biological signal transduction><bound protein><design><designing><developmental><endocrine disorder><experience><genetic regulatory protein><genome mutation><inhibitor><insight><knock-down><knockdown><member><mimetics><mutant><novel><overexpress><overexpression><pathway><pilot study><protein protein interaction><regulatory gene product><resistant><response><screening><shRNA><short hairpin RNA><small hairpin RNA><social role><summer program><summer session><trafficking><transcription factor><ubiquination><ubiquitin conjugation><undergrad><undergraduate><undergraduate student>
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Amy Brooks Smoyer

SOUTHERN CONNECTICUT STATE UNIVERSITY, NEW HAVEN, CT

Exploratory lead · 10/100
Solid budget
$414,643
FY 2022

Project Title

Impact of COVID-19 Criminal-Legal Practices on HIV Risk among Women Who Use Drugs: A Multi-Methods Qualitative Exploration

Grant Number:

1R15DA056285-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2022

End Date:

8/31/2025

Project Abstract

Project Summary/Abstract The goal of this R15 Academic Research Enhancement Award (AREA) study is to build knowledge about the impact of COVID-19 shifts in criminal-legal practices on the HIV risk behaviors of justice-involved women who use drugs (WWUD). WWUD are disproportionately impacted by HIV. ...

Research Terms

<21+ years old><AIDS Virus><AIDS prevention><Academic Research Enhancement Awards><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Acute><Address><Adult><Adult Human><Attention><Behavior><COVID><COVID crisis><COVID epidemic><COVID pandemic><COVID-19><COVID-19 affected><COVID-19 consequence><COVID-19 crisis><COVID-19 effect><COVID-19 epidemic><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 impact><COVID-19 impacted><COVID-19 pandemic><COVID-19 prevention><COVID-19 public health crisis><COVID19><COVID19 crisis><COVID19 epidemic><COVID19 global health crisis><COVID19 global pandemic><COVID19 health crisis><COVID19 pandemic><COVID19 prevention><COVID19 public health crisis><CV-19><CV19><Calendar><CoV disease><Communities><Connecticut><Consensus><Correctional Institutions><Crowding><Data><Drops><Drug usage><Economics><Employment><Environment><Goals><HIV><HIV Prevention><HIV risk><HIV/AIDS prevention><Harm Minimization><Harm Reduction><Healthcare><Housing><Human Immunodeficiency Viruses><Impoverished><Imprisonment><Incidence><Individual><Interpersonal Interaction><Interpersonal Relations><Interruption><Interview><Journals><Justice><Knowledge><LAV-HTLV-III><Lead><Left><Legal><Legal system><Lymphadenopathy-Associated Virus><Magazine><Mediating><Mediation><Mental Health><Mental Hygiene><Methods><NIH><National Institutes of Health><Negotiating><Negotiation><Newly Diagnosed><Outcome><Paper><Participant><Pb element><Peer Review><Persons><Police><Poverty><PrEP><Preventative intervention><Prisons><Procedures><Psychiatric Social Service><Psychiatric Social Work><Psychological Health><Public Policy><Qualitative Methods><R15 Mechanism><R15 Program><Research><Risk Behaviors><Risky Behavior><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-CoV2 epidemic><SARS-CoV2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Sampling><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Shapes><Social Distance><Social Service><Social Work><Social support><Sterility><Students><Syringes><Time><Uncertainty><United States National Institutes of Health><Universities><Virus-HIV><Woman><Work><access to health care><access to healthcare><accessibility of health care><accessibility to health care><accessibility to healthcare><addiction><addictive disorder><adulthood><at risk behavior><base><care services><care systems><community based service><community engaged research><community setting><condoms><conference><convention><corona virus disease><corona virus disease 2019><corona virus disease 2019 epidemic><corona virus disease 2019 pandemic><coronavirus disease><coronavirus disease 2019><coronavirus disease 2019 consequence><coronavirus disease 2019 crisis><coronavirus disease 2019 effect><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 impact><coronavirus disease 2019 pandemic><coronavirus disease 2019 prevention><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19><coronavirus disease-19 global pandemic><coronavirus disease-19 impact><coronavirus disease-19 pandemic><coronavirus disease-19 prevention><coronavirus infectious disease-19><digital><doubt><drug use><drug use behavior><experience><health care><health care access><health care availability><health care service><health care service access><health care service availability><healthcare access><healthcare accessibility><healthcare availability><healthcare service><healthcare service access><healthcare service availability><heavy metal Pb><heavy metal lead><improved><incarcerated><incarceration><interpersonal relationship><intervention for prevention><life history><pre-exposure prophylaxis><prevent COVID-19><prevent COVID19><prevent coronavirus disease 2019><prevention intervention><preventional intervention strategy><preventive intervention><prison population><programs><protective factors><psychosocial><psychosocial service><qualitative reasoning><response><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><social science research><social support network><socio-economic><socio-economically><socioeconomically><socioeconomics><sterile><summit><symposia><symposium><tool><undergrad><undergraduate><undergraduate student><web site><website>
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Swarnali Banerjee

LOYOLA UNIVERSITY OF CHICAGO, CHICAGO, IL

Exploratory lead · 10/100
Solid budget
$410,867
FY 2022

Project Title

Quelling UPEC Proliferation by Lactobacillus Mediated Induction of Latent Phages

Grant Number:

1R15AI171873-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/10/2022

End Date:

5/31/2025

Project Abstract

Prior studies have found that several Lactobacillus species inhibit the growth of or kill uropathogenic Escherichia coli (UPEC). Lactobacillus crispatus, L. gasseri, L. iners, and L. jensenii are frequent dominant members of both the healthy female vaginal and urinary microbiota and have been associ...

Research Terms

<Academic Research Enhancement Awards><Acute><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotics><Bacteria><Bacterial Genome><Bacteriophages><Benign><Bio-Informatics><Bioinformatics><Biology><Bladder><Bladder Urinary System><Catalogs><Cell Body><Cells><Cessation of life><Chicago><Co-culture><Cocultivation><Coculture><Coculture Techniques><Coliphages><Collection><Communities><Cytolysis><Death><Development><E coli><E. coli><Environment><Escherichia coli><Escherichia coli Phages><Female><Frequencies><General Taxonomy><Generalized Growth><Generations><Genes><Genome><Genomics><Genotype><Growth><H2O2><Human><Hydrogen Peroxide><Hydroperoxide><Institution><Interdisciplinary Research><Interdisciplinary Study><Investigation><Investigators><Kidney><Kidney Urinary System><Lactic acid><Lactobacillus><Life Cycle><Life Cycle Stages><Light><Liquid substance><Lysis><Lytic><Measures><Mediating><Methods><Microbe><Microbiologic Technic><Microbiologic Techniques><Microbiological Technics><Microbiological Techniques><Miscellaneous Antibiotic><Modern Man><Multidisciplinary Collaboration><Multidisciplinary Research><NIH><National Institutes of Health><Phages><Photoradiation><Play><Population><Post-Transcriptional Gene Silencing><Posttranscriptional Gene Silencing><Process><Production><Protocol><Protocols documentation><Quelling><R15 Mechanism><R15 Program><RNA Interference><RNA Silencing><RNAi><Research><Research Personnel><Researchers><Resistance to antibiotics><Resistant to antibiotics><Role><Sampling><Sequence-Specific Posttranscriptional Gene Silencing><Serotyping><Shapes><Stress><Survey Instrument><Surveys><Taxonomy><Testing><Time><Tissue Growth><UPEC><United States National Institutes of Health><Universities><Urinary Microbiome><Urinary Tract Diseases><Urinary tract><Urinary tract infection><Urinary tract infectious disease><Urine><Urine Urinary System><Urologic Diseases><Urologic Disorder><Urological Diseases><Urological Disorders><Uropathogenic E coli><Uropathogenic E. coli><Uropathogenic Escherichia coli><Vagina><Vaginal><Work><acute care><antibiotic drug resistance><antibiotic resistant><bacterial virus><biological adaptation to stress><catalog><clinical care><design><designing><developmental><experiment><experimental research><experimental study><fluid><interdisciplinary approach><life course><liquid><lower urinary tract symptoms><member><microbial consortia><microbial flora><microbiota><microflora><multidisciplinary approach><multispecies consortia><ontogeny><reactioncrisis><renal><social role><statistics><stress response><stressreaction><stressor><undergrad><undergraduate><undergraduate student><urinary><urinary bladder><urinary infection><urinary tract disorder><viral microbiome><virome>
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Catherine Elizabeth Putonti

LOYOLA UNIVERSITY OF CHICAGO, CHICAGO, IL

Exploratory lead · 10/100
Solid budget
$410,867
FY 2022

Project Title

Quelling UPEC Proliferation by Lactobacillus Mediated Induction of Latent Phages

Grant Number:

1R15AI171873-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/10/2022

End Date:

5/31/2025

Project Abstract

Prior studies have found that several Lactobacillus species inhibit the growth of or kill uropathogenic Escherichia coli (UPEC). Lactobacillus crispatus, L. gasseri, L. iners, and L. jensenii are frequent dominant members of both the healthy female vaginal and urinary microbiota and have been associ...

Research Terms

<Academic Research Enhancement Awards><Acute><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotics><Bacteria><Bacterial Genome><Bacteriophages><Benign><Bio-Informatics><Bioinformatics><Biology><Bladder><Bladder Urinary System><Catalogs><Cell Body><Cells><Cessation of life><Chicago><Co-culture><Cocultivation><Coculture><Coculture Techniques><Coliphages><Collection><Communities><Cytolysis><Death><Development><E coli><E. coli><Environment><Escherichia coli><Escherichia coli Phages><Female><Frequencies><General Taxonomy><Generalized Growth><Generations><Genes><Genome><Genomics><Genotype><Growth><H2O2><Human><Hydrogen Peroxide><Hydroperoxide><Institution><Interdisciplinary Research><Interdisciplinary Study><Investigation><Investigators><Kidney><Kidney Urinary System><Lactic acid><Lactobacillus><Life Cycle><Life Cycle Stages><Light><Liquid substance><Lysis><Lytic><Measures><Mediating><Methods><Microbe><Microbiologic Technic><Microbiologic Techniques><Microbiological Technics><Microbiological Techniques><Miscellaneous Antibiotic><Modern Man><Multidisciplinary Collaboration><Multidisciplinary Research><NIH><National Institutes of Health><Phages><Photoradiation><Play><Population><Post-Transcriptional Gene Silencing><Posttranscriptional Gene Silencing><Process><Production><Protocol><Protocols documentation><Quelling><R15 Mechanism><R15 Program><RNA Interference><RNA Silencing><RNAi><Research><Research Personnel><Researchers><Resistance to antibiotics><Resistant to antibiotics><Role><Sampling><Sequence-Specific Posttranscriptional Gene Silencing><Serotyping><Shapes><Stress><Survey Instrument><Surveys><Taxonomy><Testing><Time><Tissue Growth><UPEC><United States National Institutes of Health><Universities><Urinary Microbiome><Urinary Tract Diseases><Urinary tract><Urinary tract infection><Urinary tract infectious disease><Urine><Urine Urinary System><Urologic Diseases><Urologic Disorder><Urological Diseases><Urological Disorders><Uropathogenic E coli><Uropathogenic E. coli><Uropathogenic Escherichia coli><Vagina><Vaginal><Work><acute care><antibiotic drug resistance><antibiotic resistant><bacterial virus><biological adaptation to stress><catalog><clinical care><design><designing><developmental><experiment><experimental research><experimental study><fluid><interdisciplinary approach><life course><liquid><lower urinary tract symptoms><member><microbial consortia><microbial flora><microbiota><microflora><multidisciplinary approach><multispecies consortia><ontogeny><reactioncrisis><renal><social role><statistics><stress response><stressreaction><stressor><undergrad><undergraduate><undergraduate student><urinary><urinary bladder><urinary infection><urinary tract disorder><viral microbiome><virome>
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JONATHAN L MCMURRY

KENNESAW STATE UNIVERSITY, KENNESAW, GA

Exploratory lead · 10/100
Solid budget
$406,500
FY 2023

Project Title

Cell-penetrating peptide adaptors for intracellular cargo delivery

Grant Number:

2R15EB028609-03A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2019

End Date:

4/30/2026

Project Abstract

PROJECT SUMMARY Biomolecules that represent important therapeutic leads often fail because they cannot reach their targets, commonly because of inability to cross cell membranes and reach appropriate subcellular destinations. Cell- penetrating peptides (CPPs) have long held great promise for overco...

Research Terms

<Adaptor Protein><Adaptor Protein Gene><Adaptor Signaling Protein><Adaptor Signaling Protein Gene><Address><Affinity><Architecture><Assay><Binding><Binding Sites><Bioassay><Biochemical><Biologic Assays><Biological Assay><Biology><Calcium><Calcium-Dependent Activator Protein><Calcium-Dependent Regulator><Calmodulin><Cell Body><Cell Fractionation><Cell Surface Receptors><Cell membrane><Cells><Charge><Chimera Protein><Chimeric Proteins><Combining Site><Complex><Confocal Microscopy><Coupled><Coupling><Cytoplasm><Cytoplasmic Membrane><Destinations><Development><Dissociation><Doctor of Philosophy><Dose><Endosomes><Engineering><Engineering / Architecture><Failure><Fluorescence><Fusion Protein><Future><Generations><Goals><Human><Investigators><Kinetics><Light><Link><Location><Mammalian Cell><Mediating><Mentors><Methods><Modern Man><Molecular Interaction><Nucleic Acids><Participant><Penetration><Peptide-based drug><Peptides><Ph.D.><PhD><Phosphodiesterase Activating Factor><Phosphodiesterase Protein Activator><Photoradiation><Plasma Membrane><Preparation><Proteins><Reactive Site><Receptosomes><Research><Research Personnel><Research Training><Researchers><Rest><Sampling><System><Technology><Testing><Therapeutic><Time><Training><Trans-Activation of Transcription Protein><Trans-Activator of Transcription of HIV><Transactivating Regulatory Protein><Underrepresented Groups><Underrepresented Populations><adapter protein><design><designing><developmental><experience><experiment><experimental research><experimental study><experiments><improved><innovate><innovation><innovative><macromolecule><member><movie><next generation><peptide drug><plasmalemma><preparations><programs><prototype><recruit><subcellular fractionation><success><tat Protein><technology platform><technology system><therapeutic peptide><tool><under representation of groups><under represented groups><under represented people><under represented populations><undergrad><undergraduate><undergraduate student><underrepresentation of groups><underrepresented people>
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Gengsheng Lawrence Zeng

UTAH VALLEY UNIVERSITY, OREM, UT

Exploratory lead · 10/100
Solid budget
$373,782
FY 2022

Project Title

Reducing Metal Artifacts in Clinical X-Ray CT via Image Reconstruction Techniques

Grant Number:

2R15EB024283-03

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2018

End Date:

5/5/2026

Project Abstract

Title: Reducing Metal Artifacts in Clinical X-Ray CT via Image Reconstruction Techniques Abstract: Metallic implants such as dental fillings, surgical clips, coils, wires, and orthopedic hardware inside the patient body are very helpful in providing patients with better health benefits. On the othe...

Research Terms

<Address><Algorithms><Area><Artifacts><Back><Biomedical Engineering><Body Tissues><CAT scan><CT X Ray><CT Xray><CT imaging><CT scan><Cancer Detection><Cardiac Diseases><Cardiac Disorders><Categories><Characteristics><Clinical><Clinical Data><Computed Tomography><Computed Tomography Scanners><Computer software><Contracting Opportunities><Contracts><Data><Data Set><Dataset><Dental><Development><Diagnosis><Dorsum><Dose><Environment><Evaluation><Generations><Grant><Head and Neck Cancer><Health Benefit><Healthcare><Heart Diseases><Image><Implant><Industry><Internships><Learning><MR Imaging><MR Tomography><MRI><MRIs><Machine Learning><Magnetic Resonance Imaging><Malignant Head and Neck Neoplasm><Math Models><Measurement><Measures><Medical Imaging><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Metals><Methodology><Methods><Modeling><Morphologic artifacts><NMR Imaging><NMR Tomography><Noise><Nuclear Magnetic Resonance Imaging><Orthopedic><Orthopedic Surgical Profession><Orthopedics><Paper><Patients><Photons><Preparation><Preventive Medicine><Procedures><Protocol><Protocols documentation><Publishing><Radiation><Radiation Dose><Radiation Dose Unit><Radiation therapy><Radiotherapeutics><Radiotherapy><Research><Research Assistant><Roentgen Rays><Scanning><Software><Starvation><Students><Supervision><Surgical Clips><Techniques><Tissues><Tomodensitometry><Training><Tube><United States><Universities><Update><Utah><Variant><Variation><Vendor><Work><X-Radiation><X-Ray CAT Scan><X-Ray Computed Tomography><X-Ray Computerized Tomography><X-Ray Radiation><X-ray><Xray><Xray CAT scan><Xray Computed Tomography><Xray computerized tomography><Zeugmatography><accurate diagnosis><algorithm development><base><bio-engineered><bio-engineers><bioengineering><biological engineering><career><catscan><clinical diagnosis><clinical exam><clinical examination><college student><combat><computed axial tomography><computer tomography><computerized axial tomography><computerized tomography><cost effective><data acquisition><data exchange><data format><data transfer><data transmission><design><designing><detector><developmental><diagnostic ability><diagnostic capability><diagnostic power><diagnostic utility><diagnostic value><disease diagnosis><experience><feature extraction><head/neck cancer><health care><heart disorder><image construction><image generation><image reconstruction><image-based method><imaging><imaging method><imaging modality><innovate><innovation><innovative><interest><intern><low dose computed tomography><low dose computerized tomography><low-dose CT><machine learned><malignant head and neck tumor><mathematic model><mathematical model><mathematical modeling><metallicity><neural network><non-contrast CT><noncontrast CT><noncontrast computed tomography><preventative medicine><professor><radiation treatment><reconstruction><spectral energy><spectral image><spectral imagery><spectrograph><spectrum energy><spectrum image><spectrum imagery><statistics><tool><treatment with radiation><university student>
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Kamaleshwar P Singh

TEXAS TECH UNIVERSITY, LUBBOCK, TX

Exploratory lead · 10/100
Solid budget
$364,515
FY 2022

Project Title

Targeting oxidative stress-induced epigenetic reprogramming in fibrotic disease

Grant Number:

3R15DK121362-01A1S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2021

End Date:

6/30/2025

Project Abstract

Project Summary of Parent funded R15 (1R15DK121362-01A1) The goal of this proposed study is to evaluate whether oxidative stress-induced epigenetic changes act as a driving factor for fibrosis in kidney. Multiple or repeated acute injuries to the kidney due to chronic exposure to toxicants lead to t...

Research Terms

<Aberrant DNA Methylation><Active Oxygen><Acute><Animal Model><Animal Models and Related Studies><Antioxidants><Arsenic><Assay><Automobile Driving><Bioassay><Biologic Assays><Biological Assay><Body Tissues><Cell Body><Cell Communication and Signaling><Cell Culture Techniques><Cell Signaling><Cell-Extracellular Matrix><Cells><Cellular Morphology><ChIP Sequencing><ChIP-seq><Characteristics><Chronic><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Co-culture><Cocultivation><Coculture><Coculture Techniques><DNA><DNA Methylation><Data><Deoxyribonucleic Acid><Development><Diabetes Mellitus><Disease><Disorder><ECM><Early Diagnosis><Elderly><Endogenous Factors><Environmental Toxin><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Epithelial><Epithelial Cells><Event><Exposure to><Extracellular Matrix><Fibroblasts><Fibrosis><Folate><Folic Acid><Funding><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><General Population><General Public><Generations><Genes><Genetic Alteration><Genetic Change><Genetic defect><Goals><Grant><H2O2><Histones><Hydrogen Peroxide><Hydroperoxide><Hypertensive Nephropathy><In Vitro><Individual><Inflammation><Injury><Injury to Kidney><Intervention><Intervention Strategies><Intracellular Communication and Signaling><Kidney><Kidney Urinary System><Laboratories><Link><Molecular><Mutation><Myofibroblast><Nephrotoxic><Organ><Outcome Study><Oxidative Stress><Oxygen Radicals><Paracrine Communication><Paracrine Signaling><Parents><Pathologic><Patients><Pharmacology><Play><Pluripotent Stem Cells><Prevention><Pro-Oxidants><Process><Progenitor Cells><Property><Pteroylglutamic Acid><Reactive Oxygen Species><Renal Cell><Renal Hypertension><Renal function><Reporting><Risk Factors><Role><Signal Transduction><Signal Transduction Systems><Signaling><Source><System><Testing><Therapeutic><Tissues><Toxic Environmental Agents><Toxic Environmental Substances><Toxicant lead><Transcription Regulation><Transcriptional Control><Transcriptional Regulation><Tubular><Tubular formation><Vitamin M><Wound Repair><advanced age><anti-oxidant><base><biological signal transduction><cell culture><cell cultures><cell morphology><chromatin immunoprecipitation-sequencing><chronic kidney disease><clinical significance><clinically significant><developmental><diabetes><driving><early biomarkers><early detection><early detection biomarkers><early detection markers><effective therapy><effective treatment><elders><environmental toxicant><epigenetic therapy><fibrogenesis><genome mutation><geriatric><histone modification><hypertensive kidney><iPS><iPSC><iPSCs><in vitro Model><in vivo><in vivo Model><induced pluripotent stem cell><inducible pluripotent stem cell><injuries><interstitial><interventional strategy><kidney cell><kidney development><kidney epithelial cell><kidney fibrosis><kidney function><kidney injury><kidney toxicity><late life><later life><model of animal><model organism><mouse model><murine model><nephrogenesis><nephrotoxicity><older adult><older person><paracrine><prevent><preventing><promoter><promotor><public health relevance><renal><renal fibrosis><renal injury><restoration><senior citizen><social role><stem cell genes><stem cells><stem-like cell><stemness><toxicant><vitamin Bc><wound healing><wound resolution>
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Leslie Consitt

OHIO UNIVERSITY ATHENS, ATHENS, OH

Exploratory lead · 10/100
Solid budget
$323,788
FY 2023

Project Title

Investigating the relationship between age-related skeletal muscle insulin resistance and cognitive impairment

Grant Number:

3R15AG073922-01S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2021

End Date:

8/31/2024

Project Abstract

Abstract In this ADRD supplement, we propose to expand the scope of work in Aim 1 of our NIH/NIA 1R15AG073922 (expires 2024). The scope of work in the funded R15 centers on understanding the cellular mechanisms in skeletal muscle that contribute to age-related insulin resistance. Specifically, Aim 1...

Research Terms

<21+ years old><65+ years old><AD dementia><AD related dementia><ADRD><APOE e4><APOE-ε4><APOEε4><Administrative Supplement><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Affect><Aged 65 and Over><Aging><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's and related dementias><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimers Dementia><Amentia><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Aβ><Biological Markers><Blood><Blood Plasma><Blood Reticuloendothelial System><Body Tissues><Cause of Death><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communities><Data><Dementia><Development><Diabetes Mellitus><Disease><Disorder><Distal><Disturbance in cognition><Elderly><Enrollment><Exposure to><Faculty><Funding><Genetic><Glycogen (Starch) Synthase><Glycogen Synthase><Glycogen Synthetase><Grant><Health><Humulin R><Impaired cognition><Impairment><Individual><Insulin><Insulin Resistance><Interdisciplinary Research><Interdisciplinary Study><Investments><Ketosis-Resistant Diabetes Mellitus><Knowledge><Learning><Light><Link><MT-bound tau><Maturity-Onset Diabetes Mellitus><Mediating><Memory><Mind><Multidisciplinary Collaboration><Multidisciplinary Research><NIDDM><NIH><National Institutes of Health><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Novolin R><Ohio><Pathogenesis><Phosphorylation><Photoradiation><Plasma><Plasma Serum><Play><Primary Senile Degenerative Dementia><Process><Protein Phosphorylation><Proteins><Regular Insulin><Reporting><Research><Reticuloendothelial System, Serum, Plasma><Risk Factors><Role><Skeletal Muscle><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Students><T2 DM><T2D><T2DM><Testing><Tissues><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><UDP-Glucose Glycogen Glucosyl Transferase><United States National Institutes of Health><Universities><Voluntary Muscle><Work><a beta peptide><abeta><acylcarnitine><adult onset diabetes><adult youth><adulthood><advanced age><age 65 and greater><age 65 and older><age dependent><age related><aged><aged 65 and greater><aged ≥65><amyloid beta><amyloid-b protein><apo E-4><apo E4><apo epsilon4><apoE epsilon 4><apoE-4><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-4><apolipoprotein E4><beta amyloid fibril><bio-markers><biologic marker><biomarker><brain atrophy><cerebral atrophy><cognitive dysfunction><cognitive function><cognitive loss><cognitive performance><cohort><cortical atrophy><developmental><diabetes><elders><enroll><executive control><executive function><geriatric><glucose metabolism><glucose uptake><human old age (65+)><insight><insulin resistant><insulin signaling><ketosis resistant diabetes><late life><later life><maturity onset diabetes><microtubule bound tau><microtubule-bound tau><mild cognitive disorder><mild cognitive impairment><neurofilament><novel><old age><older adult><older person><parent grant><primary degenerative dementia><processing speed><pyruvate dehydrogenase><senile dementia of the Alzheimer type><senior citizen><skeletal muscle metabolism><skeletal muscle protein metabolism><social role><soluble amyloid precursor protein><tau><tau Proteins><tau factor><type 2 DM><type II DM><type two diabetes><young adult><young adulthood><τ Proteins>
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Edralin A. Lucas

OKLAHOMA STATE UNIVERSITY STILLWATER, STILLWATER, OK

Exploratory lead · 10/100
Active award
$168,577
FY 2023

Project Title

Prebiotic Activity of Pinto Beans Reduces Neuroinflammation in Estrogen Deficiency

Grant Number:

3R15AT011962-01S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2022

End Date:

8/31/2026

Project Abstract

Project Summary/Abstract: The prevalence of of Alzheimer’s disease (AD) is 2–3 times higher in post-menopausal women and pathology progression and memory impairment is worse in women than men. The rapid decline in circulating estrogen in postmenopausal women has been proposed as a trigger for the de...

Research Terms

<4-vinylcyclohexene diepoxide><65+ years old><AD dementia><AD prevention><Adipose tissue><Administrative Supplement><Aged 65 and Over><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease prevention><Alzheimer prevention><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease risk><Alzheimers Dementia><Area><Astrocytes><Astrocytus><Astroglia><Attenuated><Bacteria><Beta-glucuronidase><Bioavailability><Biological Availability><Biomedical Research><Body Tissues><Brain><Brain Nervous System><Cell Communication and Signaling><Cell Signaling><Clinical Research><Clinical Study><Consumption><Development><Dietary Intervention><Disease><Disease Progression><Disorder><Distant><Encephalon><Enzyme Gene><Enzymes><Equilibrium><Estrogen Metabolism><Estrogen decline><Estrogen deficiency><Estrogens><Fatty Tissue><Food><Funding><Future><GI microbiota><Gastrointestinal microbiota><Glucuronidase><Goals><Health Benefit><Health Promotion><Hortega cell><Human><Immune><Immunes><Inflammation><Intracellular Communication and Signaling><L-Tryptophan><Levotryptophan><Link><Maintenance><Memory Deficit><Memory impairment><Menopause><Metabolic><Mice><Mice Mammals><Microglia><Modeling><Modern Man><Murine><Mus><Natural Products><Nerve Cells><Nerve Unit><Nervous System><Neural Cell><Neurocyte><Neurologic Body System><Neurologic Organ System><Neurons><Nutrition Interventions><Nutritional Interventions><Outcome><Pathology><Persons><Phaseolus vulgaris><Physiologic Availability><Physiology><Phyto-Estrogen><Phytoestrogens><Population><Post-Menopause><Post-menopausal Period><Postmenopausal Period><Postmenopause><Prevalence><Prevention><Primary Senile Degenerative Dementia><Process><Production><Property><Regulation><Reporting><Research><Resistance><Risk><Role><Salutogenesis><Sampling><Short-Chain Fatty Acids><Signal Transduction><Signal Transduction Systems><Signaling><Source><Starch><Supplementation><Synaptic plasticity><Testing><Therapeutic Estrogen><Tissues><Training><Tryptophan><United States><Volatile Fatty Acids><Woman><Work><adipose><after menopause><age 65 and greater><age 65 and older><aged 65 and greater><aged ≥65><alzheimer risk><assess effectiveness><astrocytic glia><attenuate><attenuates><bacteria in the gut><bacteria pathogen><bacterial pathogen><balance><balance function><bean><behavior measurement><behavioral measure><behavioral measurement><beta-D-Glucuronoside glucuronosohydrolase><biological signal transduction><brain health><cardiometabolic><cardiometabolism><cell type><commensal bacteria><commensal bacterial species><decline in estrogen><decrease estrogen><decrease in estrogen><deficiency in estrogen><design><designing><determine effectiveness><developmental><diet intervention><disease prevention><disorder prevention><dysbacteriosis><dysbiosis><dysbiotic><effectiveness assessment><effectiveness evaluation><enteric microbial community><enteric microbiota><enzyme activity><evaluate effectiveness><examine effectiveness><experience><following menopause><food consumption><gastrointestinal microbial flora><gitter cell><graduate student><gut bacteria><gut commensal><gut community><gut flora><gut health><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiota><gut microbiotic><gut microflora><gut to brain axis><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><human old age (65+)><improved><intestinal flora><intestinal microbes><intestinal microbiota><intestinal microflora><intestinal tract microflora><memory dysfunction><men><mesoglia><microbial><microbial imbalance><microglial cell><microgliocyte><mouse model><murine model><naturally occurring product><neural><neural inflammation><neuroinflammation><neuroinflammatory><neuronal><nutrition><old age><parent project><past menopause><pathogenic bacteria><perivascular glial cell><post-menopausal><postmenopausal><postmenopausal status><prebiotics><prevent><preventing><primary degenerative dementia><primary outcome><promoting health><reduced estrogen><resistant><secondary outcome><senile dementia of the Alzheimer type><social role><training opportunity><undergrad><undergraduate><undergraduate student><vinylcyclohexene diepoxide><western diet><western-style diet><western-type diet><white adipose tissue><yellow adipose tissue><β-D-Glucuronoside glucuronosohydrolase><β-glucuronidase>
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Seung Yup Lee

KENNESAW STATE UNIVERSITY, KENNESAW, GA

Exploratory lead · 10/100
Active award
$152,347
FY 2024

Project Title

Optical Phantoms Mimicking Microvascular Cerebral Blood Flow (Supplement)

Grant Number:

3R15EB034986-01S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/6/2024

End Date:

9/20/2026

Project Abstract

PROJECT SUMMARY The primary goal of this administrative supplement project is to characterize, optimize and disseminate the optical phantoms mimicking microvascular cerebral blood flow (CBF). In our parent R15 study (EB034986) entitled “Affordable Shortwave Infrared Spectroscopy for Stroke Risk Scre...

Research Terms

<0-11 years old><3-D print><3-D printer><3D Print><3D printer><3D printing><Address><Administrative Supplement><Benchmarking><Best Practice Analysis><Blood Vessels><Blood capillaries><Blood flow><Body Tissues><Brain><Brain Nervous System><Brain Vascular><Calibration><Cell Communication and Signaling><Cell Signaling><Cerebrovascular Circulation><Cerebrum><Child><Child Youth><Children (0-21)><Clinical><Computers><Data><Diagnosis><Diameter><Diffuse><Dimensions><Disease><Disorder><Encephalon><Engineering><Ensure><Equipment><Evaluation><Faculty><Fiber><Flowmeters><Goals><Hb SS disease><HbSS disease><Hemoglobin S Disease><Hemoglobin sickle cell disease><Hemoglobin sickle cell disorder><Human><Imaging Phantoms><In Vitro><India ink><India ink stain><Institution><Intracellular Communication and Signaling><Investigators><Laboratories><Libraries><Light><Liquid substance><Measurement><Methods><Microfluidic Device><Microfluidic Lab-On-A-Chip><Microfluidic Microchips><Microfluidics><Modeling><Modern Man><Monitor><NIBIB><National Institute of Biomedical Imaging and Bioengineering><Noise><Optics><Parents><Particle Size><Performance><Photoradiation><Physiologic><Physiological><Procedures><Property><Protocol><Protocols documentation><Quality Control><Reference Standards><Reproducibility><Research Personnel><Researchers><Screening procedure><Short Waves><Sickle Cell Anemia><Signal Transduction><Signal Transduction Systems><Signaling><Spectroscopy><Spectrum Analyses><Spectrum Analysis><Standardization><System><Techniques><Technology><Technology Assessment><Temperature><Testing><Therapeutic><Thick><Thickness><TiO2><Tissues><Tube><Viscosity><absorption><arteriole><base><bases><benchmark><biological signal transduction><blood flow in brain><brain blood circulation><brain blood flow><capillary><cerebral><cerebral blood flow><cerebral circulation><cerebral vascular><cerebro-vascular><cerebrocirculation><cerebrovascular><cerebrovascular blood flow><clinical translation><clinically translatable><fabrication><fluid><improved><infrared spectroscopy><kids><liquid><lithography><microfluidic chip><millimeter><optical><parent><polydimethylsiloxane><portability><prototype><risk for stroke><risk of stroke><screening><screening tools><screenings><sickle cell disease><sickle cell disorder><sickle disease><sicklemia><stroke risk><success><three dimensional printing><titanium dioxide><titanium oxide><tool><vascular><venule><youngster><µfluidic>
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Hector Ramos Biliran

XAVIER UNIVERSITY OF LOUISIANA, NEW ORLEANS, LA

Exploratory lead · 10/100
Active award
$146,314
FY 2025

Project Title

Role of the transcriptional corepressor TLE1 in the lung adenocarcinoma aggressiveness and progression

Grant Number:

5R16GM145484-04

Activity Code:

R16

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2022

End Date:

4/30/2027

Project Abstract

Principal Investigator/Program Director (Last, first, middle): Biliran Jr., Hector Role of the transcriptional corepressor TLE1 in the lung adenocarcinoma aggressiveness and progression Abstract Lung adenocarcinoma (LUAD), which accounts for almost 40% of lung cancer, has a 5-year survival rate of o...

Research Terms

<Address><Adenocarcinoma Cell><Affect><Aggression><Aggressive behavior><Agreement><Anchorage-Independent Growth><Anoikis><Apoptotic><Automobile Driving><Award><Basal Transcription Factor><Basal transcription factor genes><Binding><Bioinformatics><Bite><Cadherin-1><Cancer Cause><Cancer Etiology><Cancer Genes><Cancer Treatment><Cancer-Promoting Gene><Cancers><Cell Attachment><Cell Line><Cell Nucleus><Cell membrane><Cell-Matrix Adhesions><Cell-Matrix Junction><CellLine><Cessation of life><ChIP Sequencing><ChIP-seq><ChIPseq><Chromatin><Complex><Cytoplasm><Cytoplasmic Membrane><Data><Death><Development><Diagnosis><Drug resistance><E-Cadherin><Enhancers><Enzyme Gene><Enzymes><Epidermoid Carcinoma><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Epithelial Calcium-Dependent Adhesion Protein><Epithelial Cells><Epithelial-Cadherin><Epithelium><Event><Gene Down-Regulation><Gene Expression><Gene Inactivation><Gene Silencing><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Genes><Genetic><Genetic Transcription><Grant><Growth><HDAC><HDAC Proteins><Histologic><Histologically><Histone Deacetylase><Human><In Vitro><Inhibitory Gt G-Protein><Integrins><Integrins Extracellular Matrix><Laboratories><Lung><Lung Adenocarcinoma><Lung Neoplasms><Lung Respiratory System><Lung Tumor><Malignant Glandular Cell><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Mediating><Mediator><Mesenchymal><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Mice><Mice Mammals><Mitochondria><Modeling><Modern Man><Molecular><Molecular Interaction><Molecular Target><Murine><Mus><NSCLC><NSCLC - Non-Small Cell Lung Cancer><Neoplasm Metastasis><Non-Small Cell Lung Cancer><Non-Small-Cell Lung Carcinoma><Nuclear><Nuclear Translocation><Nucleus><Oncogenes><Oncogenesis><Oncogenic><Patients><Phenotype><Planocellular Carcinoma><Plasma Membrane><Principal Investigator><Proteins><Pulmonary Cancer><Pulmonary Neoplasms><Pulmonary malignant Neoplasm><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Research Assistant><Resistance><Role><Secondary Neoplasm><Secondary Tumor><Signal Pathway><Squamous Carcinoma><Squamous Cell Epithelioma><Squamous cell carcinoma><Stimulus><Strains Cell Lines><Survival Rate><Testing><Tissue Growth><Transcription><Transcription Factor Proto-Oncogene><Transcription Repression><Transcription factor genes><Transcriptional Control><Transcriptional Regulation><Transducin><Transforming Genes><Transgenic Mice><Tumor Suppressor Proteins><Tumorigenicity><Uvomorulin><Work><Xenograft Model><anti-cancer therapy><bronchial epithelium><cancer metastasis><cancer progression><cancer therapy><cancer-directed therapy><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><chromatin remodeling><co-repressor><corepressor><cultured cell line><developmental><driving><drug resistant><druggable target><epigenetic gene silencing><epigenetic silencing><epigenetically><gene co-repressor><gene corepressor><gene network><gene repression><genetic co-repressor><genetic corepressor><in vivo><inhibitor><insight><lung cancer><malignancy><mitochondrial><molecular targeted therapeutics><molecular targeted therapies><molecular targeted treatment><mutant><neoplasm progression><neoplasm/cancer><neoplastic progression><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><ontogeny><overexpress><overexpression><patient prognosis><plasmalemma><prognostic ability><prognostic power><prognostic utility><prognostic value><programs><promoter><promotor><recruit><resistance to Drug><resistant><resistant to Drug><social role><student research><student-led research><therapeutic target><transcription factor><transcriptional silencing><transcriptome sequencing><transcriptomic sequencing><tumor><tumor cell metastasis><tumor progression><tumor suppressor><tumorigenesis><tumorigenic><undergrad><undergraduate><undergraduate research><undergraduate student><xenograft transplant model><xenotransplant model>
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Margaret Bennewitz

WEST VIRGINIA UNIVERSITY, MORGANTOWN, WV

Exploratory lead · 10/100
Active award
$106,400
FY 2024

Project Title

Finding NEMO's Switchable MRI Signal Using Microfluidic Tumor Models

Grant Number:

3R15CA274189-01A1S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2024

End Date:

6/30/2026

Project Abstract

PROJECT SUMMARY Misdiagnosis is prevalent in younger women with dense breast tissue receiving breast cancer screening, resulting in missed cancers, needless follow-up testing, anxiety, and medical costs. Compared to mammography, magnetic resonance imaging (MRI) detects more breast cancers but still ...

Research Terms

<3-D><3-Dimensional><3D><Active Follow-up><Address><Anxiety><Award><Benign><Blood><Blood Reticuloendothelial System><Breast Cancer><Breast Cancer Cell><Breast Cancer Detection><Breast Cancer Early Detection><Breast Cancer Early Screening><Breast MRI><Breast Magnetic Resonance Imaging><Breast Tissue><Breast cancer screening><Breast screening><Cancers><Cell Communication and Signaling><Cell Signaling><Clinic><Clinical Trials><Contrast Agent><Contrast Drugs><Contrast Media><Data><Encapsulated><Endosomes><Engineering><Environment><Evaluation><Exhibits><Extracellular Space><Gadolinium><Gd element><Goals><Intercellular Space><Intracellular Communication and Signaling><Label><MR Imaging><MR Tomography><MRI><MRIs><MUC-1><MUC1><MUC1 gene product><Magnetic Resonance Imaging><Malignant Breast Neoplasm><Malignant Neoplasms><Malignant Tumor><Mammary Gland Parenchyma><Mammary Gland Tissue><Mammogram><Mammography><Medical Care Costs><Medical Imaging><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medical Waste><Methods><Mice><Mice Mammals><Microfluidics><Mn3O4><Modeling><Muc1 Mucin><Mucin 1><Mucin 1 protein><Murine><Mus><NMR Imaging><NMR Tomography><Normal Tissue><Normal tissue morphology><Nuclear Magnetic Resonance Imaging><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Peptides><Performance><Public Health><Radiopaque Media><Receptosomes><Research><Safety><Science><Signal Transduction><Signal Transduction Systems><Signaling><Specificity><Testing><Time><Toxic effect><Toxicities><Training><Tumor Cell><Universities><West Virginia><Work><Zeugmatography><active followup><biological signal transduction><breast cancer diagnosis><breast tumor cell><chelation><follow up><follow-up><followed up><followup><hausmannite><imaging agent><imaging detection><imaging-based detection><imaging-based disease detection><improved><in vivo><innovate><innovation><innovative><malignancy><malignant breast tumor><mammary cancer detection><mammary screening><mammographic Imaging><mammographic examinations><mammographic exams><manganese oxide><manganous-manganic oxide><medical costs><medical expenses><microdevice><microfabricated device><nano><nanomaterials><neoplasm/cancer><neoplastic cell><novel><optic imaging><optical imaging><overexpress><overexpression><particle><patient oriented outcomes><portability><pre-clinical development><preclinical development><recruit><three dimensional><tumor><undergrad><undergraduate><undergraduate student><young woman><µfluidic>
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Huai Deng

UNIVERSITY OF MINNESOTA DULUTH, DULUTH, MN

Exploratory lead · 10/100
Active award
$99,958
FY 2024

Project Title

Epigenetic regulation of chromatin by the Keap1-Nrf2 xenobiotic response signaling in Drosophila

Grant Number:

3R15GM128143-02S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2018

End Date:

8/31/2026

Project Abstract

ABSTRACT We are applying for an NIH Supplement fund to support our current R15 grant, focusing on the epigenetic regulation of chromatin by the Keap1-Nrf2 xenobiotic response signaling pathway in Drosophila. The purpose of this application is to acquire a fluorescence microscope. The Keap1-Nrf2 si...

Research Terms

<Actins><Architecture><Assay><Bioassay><Biological><Biological Assay><Biological Function><Biological Process><Biology><Cancers><Cell Communication and Signaling><Cell Signaling><Chromatin><Development><Developmental Gene><Disease><Disorder><Drosophila><Drosophila genus><Ecological impact><Engineering / Architecture><Environmental Impact><Environmental Toxin><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Faculty><Funding><Grant><Health><Image><Intracellular Communication and Signaling><Laboratories><Lamins><Malignant Neoplasms><Malignant Tumor><Mediating><Microscope><Minnesota><Molecular><NIH><NURF><National Institutes of Health><Nucleosome Remodeling Factor><Oxidation-Reduction><Pathway interactions><Physical condensation><Proteins><Redox><Research><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Stimulus><Testing><Toxic Environmental Agents><Toxic Environmental Substances><Type V IF Protein><UV laboratory microscope><Ultraviolet Microscopes><United States National Institutes of Health><Universities><Xenobiotics><biologic><biological signal transduction><chromatin remodeling><condensation><developmental><environmental toxicant><epigenetic regulation><epigenetically><equipment acquirement><equipment acquisition><equipment investment><equipment procurement><equipment purchase><equipment purchasing><fluorescence imaging><fluorescence microscope><fluorescence/UV microscope><fluorescent imaging><fluorescent microscope><fruit fly><imaging><instrument><instrument acquisition><instrument investment><instrument procurement><instrument purchase><laboratory fluorescence light microscope><malignancy><member><neoplasm/cancer><novel><oxidation reduction reaction><pathway><response><undergraduate education>
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Shijie Zhou

WORCESTER POLYTECHNIC INSTITUTE, WORCESTER, MA

Exploratory lead · 10/100
Active award
$90,789
FY 2025

Project Title

Development of an automatic real-time personalized non-invasive localization of the site of origin of the earliest ventricular activation

Grant Number:

3R15HL167222-02S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2025

End Date:

8/31/2026

Project Abstract

Project Summary Sudden cardiac arrest is one of the leading causes of death in developed countries, accounting for approximately 350,000 deaths per year in the United States. The majority of those events are caused by ventricular arrhythmias (VA). Implantable defibrillators reduce mortality in high...

Research Terms

<3-D><3-Dimensional><3D><Ablation><Academic Research Enhancement Awards><Accounting><Arrhythmia><Asystole><Biomedical Engineering><Body Tissues><Cardiac><Cardiac Arrest><Cardiac Arrhythmia><Cardiac Diseases><Cardiac Disorders><Cardiac Electrophysiologic Techniques><Cardiac Electrophysiological Diagnostics><Cardiac ablation><Case Series><Catheter Ablation><Catheters><Cause of Death><Cessation of life><Clinical><Clinical Data><Clinical Treatment><Computer software><Data><Data Set><Death><Developed Countries><Development><ECG><EKG><Electrocardiogram><Electrocardiography><Event><Goals><Heart Arrest><Heart Arrhythmias><Heart Diseases><Image><Implantable Cardioverter-Defibrillators><Implantable Defibrillators><Industrialized Countries><Industrialized Nations><Lead><MR Imaging><MR Tomography><MRI><MRI Scans><MRIs><Magnetic Resonance Imaging><Magnetic Resonance Imaging Scan><Maps><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Methods><Mission><Modality><Myocardium><NHLBI><NIH><NMR Imaging><NMR Tomography><National Heart, Lung, and Blood Institute><National Institutes of Health><Nature><Nuclear Magnetic Resonance Imaging><Patient Care><Patient Care Delivery><Patients><Pb element><Premature Ventricular Beats><Premature Ventricular Contractions><Probabilistic Models><Probability Models><Procedures><Public Health><R15 Mechanism><R15 Program><Radiation therapy><Radiotherapeutics><Radiotherapy><Recurrence><Recurrent><Research><Role><Site><Software><Statistical Models><Structure><Surface><System><Techniques><Technology><Time><Tissues><United States><United States National Institutes of Health><Ventricular><Ventricular Arrhythmia><Ventricular Ectopic Beats><Ventricular Extrasystole><Ventricular Premature Complexes><Ventricular Premature Complices><Ventricular Tachycardia><Zeugmatography><bio-engineered><bio-engineers><bioengineering><biological engineering><cardiac electrophysiology><cardiac muscle><care for patients><care of patients><caring for patients><clinical database><clinical intervention><clinical therapy><computerized><developed country><developed nation><developed nations><developmental><heart disorder><heart electrophysiology><heart muscle><heavy metal Pb><heavy metal lead><high risk><image processing><imaging><improved><innovate><innovation><innovative><mortality><novel><prospective><radiation treatment><signal processing><social role><statistical linear mixed models><statistical linear models><success><three dimensional><time use><treatment with radiation><trial regimen><trial treatment><usability>
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JENNIFER V HINES

OHIO UNIVERSITY ATHENS, ATHENS, OH

Exploratory lead · 10/100
Active award
$89,716
FY 2024

Project Title

R15 AREA: Optimizing allosteric modulation of noncoding regulatory RNA function

Grant Number:

3R15GM132841-02S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2019

End Date:

8/31/2026

Project Abstract

Project Summary Bacterial drug resistance is a significant global health threat that has turned once treatable bacterial infections (including Gram-positive infections) into deadly illnesses. To overcome this serious threat to human health, completely novel antibiotics are needed. The T-box riboswit...

Research Terms

<14 year old><14 years of age><Achievement><Achievement Attainment><Anti-Bacterial Agents><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Assay><Award><Bacteria><Bacterial Drug Resistance><Bacterial Infections><Binding><Bioassay><Biological Assay><Biomedical Research><Chemicals><Computing Methodologies><Development><Drug Targeting><Elements><Ensure><Equipment><Essential Genes><Functional RNA><Future><Gram-Positive Bacteria><Health><High Throughput Assay><Human><Infection><Knowledge><Medicine><Miscellaneous Antibiotic><Modern Man><Molecular Interaction><Non-Coding><Non-Coding RNA><Non-Polyadenylated RNA><Non-translated RNA><Noncoding RNA><Nontranslated RNA><Outcome><Pathogenicity><Process><Public Health><RNA><RNA Binding><RNA Gene Products><RNA bound><Reader><Request for Proposals><Research><Resistance><Ribonucleic Acid><Testing><Therapeutic Agents><Training><Transfer RNA><Triplet Codon-Amino Acid Adaptor><Untranslated RNA><Viral><age 14 years><anti-bacterial><anti-bacterial drug resistance><anti-bacterial drug resistant><anti-bacterial resistance><anti-bacterial resistant><anti-cancer><bacteria infection><bacterial disease><career><computational methodology><computational methods><computer based method><computer methods><computing method><design><designing><developmental><drug discovery><experience><fourteen year old><fourteen years of age><global health><high throughput screening><improved><inhibitor><innovate><innovation><innovative><instrument><next generation><noncoding><novel><parent award><parent project><rational design><resistance to anti-bacterial><resistant><resistant to anti-bacterial><small molecule><success><tRNA><transfer Ribonucleic acids><undergrad><undergraduate><undergraduate research><undergraduate student>
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Michael R. Nichols

UNIVERSITY OF MISSOURI-ST. LOUIS, SAINT LOUIS, MO

Exploratory lead · 10/100
Active award
$85,184
FY 2024

Project Title

Mechanisms of NLRP3 inflammasome activation

Grant Number:

3R15GM152964-01S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/20/2023

End Date:

8/31/2026

Project Abstract

PROJECT SUMMARY/ABSTRACT The instrument requested in this Administrative Supplement for Equipment Purchase is a Tecan Spark Cyto 400 multimode cell imaging plate reader, which will significantly enhance the research aims of the parent grant award (1R15GM152964-01) and the research environment at the...

Research Terms

<20 year old><20 years of age><Administrative Supplement><Alzheimer beta-Protein><Alzheimer's Amyloid beta-Protein><Alzheimer's amyloid><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Assay><Award><Aβ><Bioassay><Biological Assay><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cell Body><Cells><Environment><Fluorescence><Health><Heart Vascular><Human><Immune><Immunes><Inflammasome><Inflammation><Institution><Investigators><Lead><Mechanics><Missouri><Modern Man><NIH><National Institutes of Health><Nerve Degeneration><Neuron Degeneration><Parents><Pb element><Phase><Proteins><Reader><Research><Research Personnel><Researchers><Speed><Students><Training><United States National Institutes of Health><Universities><a beta peptide><abeta><age 20 years><amyloid beta><amyloid-b protein><beta amyloid fibril><cell imaging><cellular imaging><circulatory system><equipment acquirement><equipment acquisition><equipment investment><equipment procurement><equipment purchase><equipment purchasing><heavy metal Pb><heavy metal lead><imaging capabilities><improved><instrument><instrument acquisition><instrument investment><instrument procurement><instrument purchase><live cell image><live cell imaging><live cellular image><live cellular imaging><luminescence><mechanic><mechanical><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neuronal degeneration><parent><parent award><parent grant><parent project><soluble amyloid precursor protein><twenty year old><twenty years of age><undergrad><undergraduate><undergraduate student>
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Perla B. Gamez

LOYOLA UNIVERSITY OF CHICAGO, CHICAGO, IL

Exploratory lead · 0/100
$248,691
FY 2024

Project Title

Spanish-speaking Latinos' Early Language Environments and Dual Language Development

Grant Number:

3R15HD097589-02S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/24/2019

End Date:

7/31/2025

Project Abstract

PROJECT SUMMARY Language “nutrition” or access to rich language exposure nourishes children's language development. In turn, “healthy” language outcomes lead to academic success. Despite widespread agreement on the importance of direct exposure to primary caregivers' language (direct input), there i...

Research Terms

<0-11 years old><Agreement><Award><Behavior><Care Givers><Caregivers><Child><Child Language><Child Support><Child Youth><Children (0-21)><Code><Coding System><Data><Development><Development Plans><Development and Research><Emotional><Environment><Espanol><Exposure to><Family><Fostering><Grant><Health><Knowledge><Language><Language Development><Latino><Latino Population><Latino group><Latino individual><Latino people><Latinos><Lead><Linguistic><Linguistics><Mentors><Methods><NIH><National Institutes of Health><Outcome><Parents><Pathway interactions><Pb element><Play><Position><Positioning Attribute><Publishing><R & D><R&D><Research><Research Activity><Science><Source><Spanish><Speech><Structure><United States National Institutes of Health><Video Recording><Videorecording><acquiring language skills><bilingual><bilingualism><care giving><career><career development><caregiving><cohesion><conference><convention><cultural values><developmental><dyadic interaction><experience><hands on research><heavy metal Pb><heavy metal lead><innovate><innovation><innovative><journal article><kids><language acquisition><language learning><language outcome><meeting><meetings><nutrition><parent><parent grant><pathway><primary care giver><primary caregiver><professor><research and development><skill acquisition><skill development><success><summit><symposia><symposium><video recording system><youngster>
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Kelsey A. Bonfils

UNIVERSITY OF SOUTHERN MISSISSIPPI, HATTIESBURG, MS

Exploratory lead · 0/100
$219,638
FY 2023

Project Title

Sleep disturbance and inflammation as determinants of social cognition and behavior: An intensive longitudinal study of adults with schizophrenia-spectrum disorders (NIH Supplemental)

Grant Number:

3R15MH129814-01S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2022

End Date:

6/14/2025

Project Abstract

ABSTRACT People with schizophrenia-spectrum disorders (SSDs) experience deficits in social cognition, which contribute to real-world functional outcomes. As such, social cognition is an important treatment target in SSDs. Yet, current research has not adequately focused on determinants of social cog...

Research Terms

<(TNF)-α><21+ years old><Acute><Address><Adult><Adult Human><After Care><After-Treatment><Aftercare><Area><Award><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Blood><Blood Reticuloendothelial System><C-reactive protein><Cachectin><Cognitive><Cognitive deficits><Complement><Complement Proteins><Computer software><Country><Data><Data Sources><Dryness><Ecological momentary assessment><Education><Educational aspects><Emotional Depression><Financial Support><Funding><Future><Goals><HPGF><Hepatocyte-Stimulating Factor><Hybridoma Growth Factor><IFN-beta 2><IFNB2><IL-6><IL6 Protein><Inflammation><Inflammatory><Interleukin-6><Intervention><Intervention Strategies><Investigation><Knowledge><Light><Link><Longitudinal Studies><MGI-2><Macrophage-Derived TNF><Measurement><Measures><Mentors><Mentorship><Methods><Mississippi><Monocyte-Derived TNF><Myeloid Differentiation-Inducing Protein><NIH><NIMH><National Institute of Mental Health><National Institutes of Health><Outcome><Parents><Participant><Patient Self-Report><Perception><Persons><Photoradiation><Pittsburgh Sleep Quality Index><Plasmacytoma Growth Factor><Position><Positioning Attribute><Proteins, specific or class, C-reactive><Psychology><QOL><Qualitative Research><Quality of life><Reporting><Research><Research Resources><Resources><Sampling><Schizophrenia><Schizophrenic Disorders><Schools><Self-Report><Sleep><Sleep disturbances><Social Behavior><Social Functioning><Social outcome><Software><Spottings><Strategic Planning><Students><Symptoms><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Testing><Time><Training><Travel><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><United States National Institutes of Health><Universities><Work><aberrant sleep><actigraph><actigraphy><adulthood><chronic mental illness><cognitive defects><conference><convention><cytokine><deficit syndrome><dementia praecox><depression symptom><depressive><depressive symptoms><develop therapy><disrupted sleep><disturbed sleep><diversity, equity, and inclusiveness><equity, diversity, and inclusion><experience><financial assistance><functional improvement><functional outcomes><graduate student><impaired sleep><improve function><improved><improved functional outcomes><inflammation marker><inflammatory marker><interest><interferon beta 2><intervention development><interventional strategy><irregular sleep><long-term study><longitudinal outcome studies><longterm study><multi-modal data><multi-modal datasets><multi-modality><multimodal data><multimodal datasets><multimodality><novel><parent><persistent mental illness><phenomenological models><phenomenology><poor sleep><post treatment><programs><schizophrenia spectrum><schizophrenia spectrum disorder><schizophrenic><serious mental disorder><serious mental illness><severe mental disorder><severe mental illness><sleep disruption><sleep dysregulation><social><social cognition><social determinants><sociobehavior><sociobehavioral><sociodeterminant><student training><summit><symposia><symposium><therapy development><tool><training opportunity><treatment development><undergrad><undergraduate><undergraduate student>
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Karen S Kim Guisbert

FLORIDA INSTITUTE OF TECHNOLOGY, MELBOURNE, FL

Exploratory lead · 0/100
$201,368
FY 2023

Project Title

The Role of Calcium Transients in Fertilization and Early Embryogenesis in C. elegans

Grant Number:

1R15HD111986-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2023

End Date:

8/17/2024

Project Abstract

Project Summary Human development begins with an internal fertilization event. However, internal fertilization is notoriously difficult to visualize in vivo. Taking advantage of the universally conserved calcium response that is a hallmark of sperm-egg fusion in all species, we have adapted the gen...

Research Terms

<Academic Research Enhancement Awards><Address><Animals><Biologic Models><Biological Models><C elegans><C. elegans><C.elegans><Caenorhabditis elegans><Calcium><Calcium Ion Signaling><Calcium Oscillations><Calcium Signaling><Calcium Spikes><Calcium Waves><Cannot achieve a pregnancy><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Interaction><Cell Signaling><Cell division><Cell-to-Cell Interaction><Cells><Coloring Agents><Communication><Competence><Complement><Complement Proteins><Complex><Consumption><Cytology><Data><Defect><Dependence><Development><Developmental Biology><Difficulty conceiving><Dyes><Education><Educational aspects><Educational process of instructing><Embryo><Embryo Development><Embryo Experimentation><Embryo Research><Embryogenesis><Embryonic><Embryonic Development><Event><Fecundability><Fecundity><Fertility><Fertilization><Florida><Gametes><Genetic><Germ Cells><Germ-Line Cells><Goals><Gonadal structure><Human><Human Development><Image><In Vitro><Infertility><Injections><Intracellular Communication and Signaling><Knowledge><Learning><Marriage><Meiosis><Microscopy><Miscarriage><Mitotic><Model System><Modern Man><Molecular><Nature><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Oocytes><Optics><Organism><Ovocytes><Ovulation><Pattern><Phase><Phenotype><Physiology><Process><R-Series Research Projects><R01 Mechanism><R01 Program><R15 Mechanism><R15 Program><RNA interference screen><RNAi screen><RNAi-based screen><Regulation><Reporter><Reporting><Reproductive Cells><Reproductive Medicine><Research><Research Grants><Research Infrastructure><Research Project Grants><Research Projects><Role><Series><Sex Cell><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Slice><Specificity><Sperm><Spermatozoa><Spontaneous abortion><Students><System><Teaching><Techniques><Technology><Testing><Time><Visualization><biochemical tools><biochemistry tools><biological signal transduction><calcium indicator><cell type><course redesign><critical period><design><designing><developmental><egg><experiment><experimental research><experimental study><experiments><fertility cessation><fertility loss><fertilizations><gastrulation><gonad><gonads><imaging><improved><in vivo><infertile><initial cell><innovate><innovation><innovative><insight><knock-down><knockdown><lab experience><lab training><laboratory experience><laboratory training><living system><meiotic><model organism><neuronal><novel><optical><prevent><preventing><response><sexual cell><social role><sperm cell><student engagement><student motivation><student participation><tool><undergrad><undergraduate><undergraduate research experience><undergraduate research opportunities><undergraduate research programs><undergraduate student><zoosperm>
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Christina Scherrer

KENNESAW STATE UNIVERSITY, KENNESAW, GA

Exploratory lead · 0/100
$154,840
FY 2022

Project Title

Removing Barriers to Fluoride Varnish Application in Primary Care Settings (Supplement)

Grant Number:

3R15DE031428-01S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/22/2022

End Date:

2/14/2025

Project Abstract

Removing Barriers to Fluoride Varnish Application in Primary Care Settings (Supplement) Project Summary/Abstract: Dental decay is an important, ongoing public health concern that impacts children from low-income households and from racial and ethnic minorities at higher rates than the general popula...

Research Terms

<0-11 years old><Address><Administrative Supplement><Area><Award><Caries><Characteristics><Child><Child Youth><Childhood><Children (0-21)><Clinic><Consolidated Framework for Implementation Research><Consolidated Framework for Implementation Science><Consolidated Framework for Implementing Change><Data><Decision Making><Decrease health disparities><Dental><Dental Decay><Dental caries><Dentists><Development><Effectiveness><Engineering><Federally Qualified Health Center><Fluoride Varnishes><Funding><General Population><General Public><Goals><Grant><Health Services><Health disparity mitigation><Health disparity reduction><Household><Individual><Industrialization><Insurance><Interview><Investigators><Low income><Lower health disparities><Maps><Methods><Mitigate health disparities><Modeling><NIH><National Institutes of Health><Oral health><Parents><Patients><Perception><Physicians><Physicians' Offices><Play><Population><Prevalence><Preventative care><Preventative intervention><Preventive><Preventive care><Primary Care><Primary Health Care><Primary Healthcare><Provider><Public Health><Reduce health disparities><Research><Research Personnel><Research Resources><Researchers><Resources><Role><Site><Specialist><Students><Suggestion><Survey Instrument><Surveys><Time><Underserved Population><Uninsured><United States National Institutes of Health><Visit><Well Child Visits><Work><base><care providers><cost><dental health><developmental><disparities in race><disparity in health><economic disparity><ethnic minority><experience><facilitators to implementation><federal poverty level><health disparity><implementation facilitators><implementation science><improved><insight><interest><intervention for prevention><military member><model-based simulation><models and simulation><parent project><pediatric><prevention intervention><preventional intervention strategy><preventive intervention><primary care provider><primary care setting><programs><race disparity><racial disparity><racial inequality><racial inequity><racial minority><racially unequal><recruit><safety net><service member><service organization><social role><tooth decay><under served group><under served people><under served population><underserved group><underserved people><youngster>
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CYNTHIA CORBITT

UNIVERSITY OF LOUISVILLE, LOUISVILLE, KY

Exploratory lead · 0/100
$148,389
FY 2023

Project Title

Prenatal Cigarette Smoke Exposure: Impact on Offspring Gut Bacterial Microbiome

Grant Number:

3R15ES028440-02A1S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2023

End Date:

5/31/2025

Project Abstract

ABSTRACT This Research Supplement to Promote Diversity in Health-Related Research is to support a graduate student to perform research funded by R15 award 2R15ES028440-02A1, Prenatal Cigarette Smoke Exposure: Impact on Offspring Gut Bacterial Microbiome. Mr. Isaiah Burciaga is eligible for this awar...

Research Terms

<0-11 years old><Acetates><Age><Age Months><Air><Assay><Attenuated><Award><Behavior Disorders><Behavioral><Bioassay><Biologic Assays><Biological Assay><Biomedical Research><Birth Weight><Birth length><Blood Glucose><Blood Plasma><Blood Serum><Blood Sugar><Brain><Brain Nervous System><Calorimetry><Carbohydrates><Cecum><Cell Communication and Signaling><Cell Signaling><Characteristics><Chemicals><Child><Child Youth><Children (0-21)><Coupled><D-Glucose><DEXA><DXA><Data><Development><Dextrose><Dual-Energy X-Ray Absorptiometry><Dual-Energy Xray Absorptiometry><Dyslipidemias><Eating><Economically Deprived><Eligibility><Eligibility Determination><Encephalon><Endocrine Gland Secretion><Euthanasia><Exhibits><Family><Fasting><Feces><Female><Fermentation><Firmicutes><First Generation College Students><First Generation College graduates><First Generation Students><Food Intake><Functional impairment><Funding><GI microbiome><GI microbiota><GLP-1><Gastrointestinal microbiota><Gene Expression><Generalized Growth><Genes><Gestation><Gestational cigarette smoke exposure><Glucose><Glucose Intolerance><Glucose tolerance test><Goals><Grant><Growth><Health><Hepatic><High Fat Diet><Hormones><Hour><Humulin R><IPGTT><Immune system><Immunologist><Inflammation><Inhalation><Inhaling><Insulin><Intervention><Intervention Strategies><Intestinal><Intestines><Intracellular Communication and Signaling><Kentucky><Latino><Link><Lipids><Liver><Low Birth Weight Infant><Lupus><Measures><Mediating><Mercy Killing><Metabolic><Metabolic syndrome><Mice><Mice Mammals><Modeling><Murine><Mus><Novolin R><Nutritional><Organ><Over weight><Overweight><Pancreas><Pancreatic><Parents><Passive Smoke Exposure><Phenotype><Plasma><Plasma Serum><Pregnancy><Prenatal Tobacco Smoke><Production><Proteobacteria><Protocol><Protocol Screening><Protocols documentation><Puberty><Publications><Purple Bacteria><RNA Seq><RNA sequencing><RNAseq><Regular Insulin><Reporting><Research><Research Training><Resistance><Reticuloendothelial System, Serum, Plasma><Rural><Same-sex><Scanning><Science><Scientific Publication><Serum><Short-Chain Fatty Acids><Signal Transduction><Signal Transduction Systems><Signaling><Smoke><Starch><Structure><Students><Supplementation><Testing><Therapeutic Hormone><Tissue Growth><Transplantation><Underrepresented Ethnic Minority><Underrepresented Minority><Variant><Variation><Volatile Fatty Acids><Weaning><Woman><Work><Writing><absorption><ages><alter microbiome><attenuate><attenuates><bacterial community><bacterial microbiome><bacteriome><behavioral disorder><beta diversity><biological signal transduction><bowel><career><cigarette smoke exposure><cigarette smoking><cigarette use><conference><convention><developmental><dietary><digestive tract microbiome><disadvantaged background><disparate effect><disparate impact><disparate result><dysbacteriosis><dysbiosis><dysbiotic><economic disparity><economically disadvantaged><enteric microbial community><enteric microbiome><enteric microbiota><environmental tobacco smoke exposure><exposure to ETS><exposure to SHS><exposure to cigarette smoke><exposure to environmental tobacco smoke><exposure to secondhand smoke><exposure to tobacco smoke><fasted><fasts><fetal tobacco exposure><functional disability><gastrointestinal microbial flora><gastrointestinal microbiome><glucagon-like peptide 1><graduate school><graduate student><gut commensal><gut community><gut dysbiosis><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><hepatic body system><hepatic organ system><impaired glucose tolerance><in utero><inequitable effect><inequitable impact><inequitable outcome><insulin sensitivity><interest><interventional strategy><intestinal biome><intestinal flora><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><intraperitoneal glucose tolerance test><kids><low birth weight><low birthweight><male><marginalized background><metabolic phenotype><metabolism measurement><metabolomics><metabonomics><metabotype><microbial><microbial composition><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome adaptation><microbiome alteration><microbiome community composition><microbiome composition><microbiome perturbation><microbiome species composition><microbiota><microflora><mouse model><multispecies consortia><murine model><nutritious><obesity risk><offspring><ontogeny><outcome disparities><outcome inequality><outcome inequity><parent><postnatal><pregnant><prenatal><prenatal smoking><prenatal tobacco exposure><prenatally tobacco exposed><pup><resistant><risk for obesity><risk of obesity><second hand smoke exposure><secondhand smoke exposure><secondhand tobacco smoke exposure><sex><smoking during pregnancy><stool><summit><symposia><symposium><transcriptome sequencing><transcriptomic sequencing><transcriptomics><transplant><unborn><under-representation of minorities><under-represented minority><underrepresentation of minorities><unequal effect><unequal impact><unequal outcome><youngster>
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Matthew Salanga

NORTHERN ARIZONA UNIVERSITY, FLAGSTAFF, AZ

Exploratory lead · 0/100
$147,446
FY 2022

Project Title

The effects of depleted uranium shrapnel on mitochondrial cellular function, administrative diversity supplement

Grant Number:

3R15ES032923-01S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/12/2022

End Date:

4/30/2025

Project Abstract

PROJECT ABSTRACT A consequence of modern combat is exposure to depleted uranium through the use of uranium-containing munitions. Understanding the effects of environmental or occupational exposure to depleted uranium is important for protecting human health. Research in the area of uranium chemical...

Research Terms

<7-hydroxy-3H-phenoxazin-3-one 10-oxide><Actinic Rays><Acute><Address><Adverse effects><Alamar Blue><AlamarBlue><Ampullary Crest><Applications Grants><Aptitude><Area><Arizona><Armed Forces Personnel><Assay><Assistantship><Attention><Award><Bioassay><Biologic Assays><Biological Assay><Brachydanio rerio><Breathing><Cancers><Cell Body><Cell Function><Cell Process><Cell physiology><Cells><Cellular Function><Cellular Physiology><Cellular Process><Chemicals><Chronic><Coloring Agents><Comment><Commentary><Crista ampullaris><Cytochrome Oxidase><DNA><DNA Damage><DNA Injury><Danio rerio><Data><Data Display><Deoxyribonucleic Acid><Development><Drug or chemical Tissue Distribution><Dyes><E-F1><EF-1H><Editorial Comment><Educational process of instructing><Educational workshop><Electron Transport Complex IV><Elongation Factor 1><Environmental Exposure><Eukaryotic Translation Elongation Factor 1><Exposure to><Faculty><Ferrocytochrome c Oxygen Oxidoreductase><Genetic><Genome><Goals><Grant><Grant Proposals><Grant Review><Health><Home><Human><Impairment><Ingestion><Intermediary Metabolism><Investigation><Investigators><Isotopes><Laboratories><Larva><Lead><Malignant Neoplasms><Malignant Tumor><Manuscripts><Mentors><Mentorship><Metabolic><Metabolic Processes><Metabolism><Methods><Military><Military Personnel><Mitochondria><Mitochondrial DNA><Modern Man><Modernization><Molecular Target><NIH><National Institutes of Health><Native Americans><Native Hawaiian><Navaho><Navajo><Nuclear><Nuclear Weapon><Occupational Exposure><Organelles><Parents><Pb element><Penetration><Peptide Elongation Factor 1><Persons><Ph D student><Ph D. student><Ph. D. student><Ph.D student><Ph.D. student><PhD student><PhD. student><Phenotype><Physiology><Play><Populations at Risk><Prevention program><Principal Investigator><Published Comment><Radioactive Isotopes><Radioactivity><Radioisotopes><Radionuclides><Reagent><Reporter><Research><Research Activity><Research Design><Research Personnel><Researchers><Respiratory Aspiration><Respiratory Inspiration><Risk><Role><Science><Site><Skin><Soil><Structure><Students><Study Type><Subcellular Process><Teaching><Testing><Time><Tissue Distribution><Toxic effect><Toxicities><Toxicology><Training><Transgenes><Transmission Electron Microscopy><Tribes><U element><UV light><UV radiation><UV rays><Ultraviolet Rays><Uncertainty><United States><United States National Institutes of Health><Universities><Uranium><Viewpoint><Visualization><Water contamination><Workshop><Writing><Zebra Danio><Zebra Fish><Zebrafish><base><cancer prevention><combat><contaminated water><crista ampulla><cristae><cytochrome c oxidase><developmental><diazoresorcinol><doctoral student><doubt><experience><heavy metal Pb><heavy metal lead><improved><in vivo><inspiration><malignancy><meetings><member><military population><mitochondrial><mitochondrial dysfunction><mitochondrial genome><mtDNA><neoplasm/cancer><novel><parent grant><particle><particle exposure><promoter><promotor><reazurin><reazurine><resazurin><resorufin><social role><study design><subcutaneous><subdermal><success><tissue wound><tool><ultra violet light><ultra violet radiation><ultra violet rays><ultraviolet light><ultraviolet radiation><undergrad><undergraduate><undergraduate student><water-borne><waterborne><weapons><workplace exposure><wound><wounding><wounds>
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CATALIN V. BUHUSI

UTAH STATE UNIVERSITY, LOGAN, UT

Exploratory lead · 0/100
$145,996
FY 2024

Project Title

Arousal and Timekeeping in a Mouse Model of Parkisonism (Supplement)

Grant Number:

3R15NS123824-01A1S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2026

Project Abstract

PROJECT SUMMARY / ABSTRACT This is an application for an administrative supplement to the original R15 application "Arousal and Timekeeping in a Mouse Mode of Parkinsonism" to extend our studies to mouse models of Alzheimer's Disease. Neurodegenerative disorders like Parkinson’s Disease (PD), Huntin...

Research Terms

<AD dementia><AD model><Address><Administrative Supplement><Agonist><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease model><Alzheimer's disease patient><Alzheimer's patient><Alzheimers Dementia><Animal Model><Animal Models and Related Studies><Arousal><Association Learning><Associative Learning><Behavioral><Biochemical><C57BL/6 Mouse><Clinical Treatment><Cognition><Cognitive><Cognitive deficits><Corpus Striatum><Corpus striatum structure><Data><Decision Making><Degenerative Neurologic Disorders><Diurnal Rhythm><Dopamine><Drugs><Episodic memory><Genetic><Grant><Hcrt protein><Hcrt/ORX><Hcrts/ORXs><Huntington Chorea><Huntington Disease><Huntington's><Huntington's Disease><Huntingtons Disease><Hydroxytyramine><Hypothalamic structure><Hypothalamus><Impairment><Investigation><Lateral><Medication><Memory><Methods><Mice><Mice Mammals><Modeling><Motor><Murine><Mus><NIH><National Institutes of Health><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neurons><Paralysis Agitans><Parkinson><Parkinson Disease><Parkinsonian><Parkinsonian Condition><Parkinsonian Diseases><Parkinsonian Disorders><Parkinsonian Syndrome><Parkinsonism><Patients><Pavlovian conditioning><Performance><Pharmaceutical Preparations><Primary Parkinsonism><Primary Senile Degenerative Dementia><Process><Production><Protocol><Protocols documentation><Reaction Time><Reproduction><Response RT><Response Time><Role><Sleep><Sleep Wake Cycle><Striate Body><Striatum><Time><United States National Institutes of Health><Wakefulness><alertness><alzheimer model><associative conditioning><classical conditioning><cognitive control><cognitive defects><cognitive function><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><diurnal variation><drug/agent><executive control><executive function><frontal cortex><frontal lobe><hypocretin><hypocretin/orexin><hypocretins/orexins><hypothalamic><improved><innovate><innovation><innovative><memory recognition><migration><model of animal><motivated behavior><motor control><mouse model><murine model><neural circuit><neural circuitry><neurocircuitry><neurodegenerative illness><neuronal><neuronal circuit><neuronal circuitry><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><object recognition><orexin><parent grant><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><pharmacologic><primary degenerative dementia><psychomotor reaction time><response><senile dementia of the Alzheimer type><social role><spatial memory><stem><striatal><sustained attention><synaptic circuit><synaptic circuitry><treatment strategy><trial regimen><trial treatment><vigilance>
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Ryan McGorty

UNIVERSITY OF SAN DIEGO, SAN DIEGO, CA

Exploratory lead · 0/100
$144,272
FY 2022

Project Title

Biomimetic cytoskeleton and advanced microscopy to reveal intracellular DNA dynamics and distributions

Grant Number:

3R15GM123420-02S2

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2017

End Date:

5/31/2024

Project Abstract

Project Summary/Abstract The proposed diversity supplement is to support early career faculty member, Dr. Janet Sheung, a Chinese woman in her 2nd year of a tenure-track faculty position in the W.M. Keck Science Department at Scripps College, a predominantly undergraduate institution similar to Univ...

Research Terms

<Biological Mimetics><Biomimetics><Biophysics><Cellular Matrix><Chinese><Circular DNA><Collaborations><Cytoskeletal System><Cytoskeleton><DNA><Deoxyribonucleic Acid><Discipline><Exhibits><Faculty><Fluorescence><Funding><Goals><Grant><Health><High School Student><Home><In Vitro><Institution><Interdisciplinary Research><Interdisciplinary Study><Investigators><Light><Link><Measurement><Measures><Mechanics><Mentors><Methods><Microscope><Microscopy><Modernization><Molecular Configuration><Molecular Conformation><Molecular Stereochemistry><Multidisciplinary Collaboration><Multidisciplinary Research><Parents><Photoradiation><Position><Positioning Attribute><Program Accessibility><Property><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Science><Secondary School Student><Secondary Student><Spatial Distribution><Time><Universities><Woman><arm><biophysical foundation><biophysical principles><biophysical sciences><career><college><collegiate><conformation><conformational state><design><designing><early-career faculty><experience><experiment><experimental research><experimental study><innovate><innovation><innovative><instrument><instrumentation><intracellular skeleton><laser tweezer><macromolecule><mechanical><member><novel><optical tweezers><programs><skills><summer research><tenure process><tenure track><undergrad><undergraduate><undergraduate student>
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Rae Marie Robertson-Anderson

UNIVERSITY OF SAN DIEGO, SAN DIEGO, CA

Exploratory lead · 0/100
$144,272
FY 2022

Project Title

Biomimetic cytoskeleton and advanced microscopy to reveal intracellular DNA dynamics and distributions

Grant Number:

3R15GM123420-02S2

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2017

End Date:

5/31/2024

Project Abstract

Project Summary/Abstract The proposed diversity supplement is to support early career faculty member, Dr. Janet Sheung, a Chinese woman in her 2nd year of a tenure-track faculty position in the W.M. Keck Science Department at Scripps College, a predominantly undergraduate institution similar to Univ...

Research Terms

<Biological Mimetics><Biomimetics><Biophysics><Cellular Matrix><Chinese><Circular DNA><Collaborations><Cytoskeletal System><Cytoskeleton><DNA><Deoxyribonucleic Acid><Discipline><Exhibits><Faculty><Fluorescence><Funding><Goals><Grant><Health><High School Student><Home><In Vitro><Institution><Interdisciplinary Research><Interdisciplinary Study><Investigators><Light><Link><Measurement><Measures><Mechanics><Mentors><Methods><Microscope><Microscopy><Modernization><Molecular Configuration><Molecular Conformation><Molecular Stereochemistry><Multidisciplinary Collaboration><Multidisciplinary Research><Parents><Photoradiation><Position><Positioning Attribute><Program Accessibility><Property><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Science><Secondary School Student><Secondary Student><Spatial Distribution><Time><Universities><Woman><arm><biophysical foundation><biophysical principles><biophysical sciences><career><college><collegiate><conformation><conformational state><design><designing><early-career faculty><experience><experiment><experimental research><experimental study><innovate><innovation><innovative><instrument><instrumentation><intracellular skeleton><laser tweezer><macromolecule><mechanical><member><novel><optical tweezers><programs><skills><summer research><tenure process><tenure track><undergrad><undergraduate><undergraduate student>
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Morgan J Hawker

CALIFORNIA STATE UNIVERSITY FRESNO, FRESNO, CA

Exploratory lead · 0/100
$140,000
FY 2023

Project Title

Controlling Naturally-Derived Polymer Enzymatic Degradation: A Plasma-Enhanced Chemical Vapor Deposition Approach

Grant Number:

5SC2GM141648-03

Activity Code:

SC2

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/1/2021

End Date:

6/30/2025

Project Abstract

Project Summary Biomaterial implants are natural or synthetic materials that can be placed in the body to improve human health in multiple ways, including delivering drugs to targeted regions of the body, healing wounds, and maintaining organ function. It is important that implants do not break down...

Research Terms

<2-Propen-1-amine><3-Aminopropylene><Abscission><Address><Adsorption><Alcohol Chemical Class><Alcohols><Allylamine><American><Area><Award><Behavior><Biochemical><Biocompatible Materials><Biologic Models><Biological><Biological Models><Biomaterials><Biopolymers><Blood Plasma><Body Regions><Body Tissues><Cellulose><Chemicals><Chemistry><Chitin><Collaborations><Collagen><Data><Deposit><Deposition><Development><Device Removal><Devices><Drugs><Dryness><Environment><Enzyme Gene><Enzyme Interaction><Enzymes><Excision><Exhibits><Exposure to><Extirpation><FTIR><FTIR spectroscopy><Fibroins><Film><Funding><Future><Gases><Goals><Health><Hip Prosthesis Implantation><Human><Hydrolysis><Hydrophobic Surfaces><Hydrophobicity><Hygroscopicity><Implant><In Vitro><Infection><Investigators><Leanness><Life><Liquid substance><Measures><Mechanics><Mediating><Medical Device><Medication><Mentors><Mentorship><Methodology><Methods><Model System><Modeling><Modern Man><Modification><Morphology><NIH><National Institutes of Health><Organ><Pain><Painful><Pentanes><Pharmaceutic Preparations><Pharmaceutical Preparations><Plasma><Plasma Enhancement><Plasma Serum><Play><Polyanhydroglucuronic Acid><Polymer Chemistry><Polymers><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Predisposition><Process><Pronase><Property><Protease XIV><Proteins><Public Health><Removal><Reporting><Research><Research Associate><Research Personnel><Research Resources><Researchers><Resources><Reticuloendothelial System, Serum, Plasma><Roentgen Rays><Role><Route><Scanning Electron Microscopy><Silk><Solid><Spectroscopy><Spectroscopy, Fourier Transform Infrared><Spectrum Analyses><Spectrum Analysis><Structure><Surface><Surface Properties><Surgical Removal><Susceptibility><System><Techniques><Testing><Thinness><Time><Tissues><Tooth Extraction><United States National Institutes of Health><Wettability><Work><Wound Repair><X-Radiation><X-Ray Radiation><X-ray><Xray><alpha-Cellulose><alpha-chymotrypsin><biodegradable polymer><biologic><biological material><biomedical implant><bioresorbable polymer><career><chymotrypsin A><chymotrypsin A alpha><crosslink><degradable polymer><developmental><drug/agent><experience><flexibility><flexible><fluid><functional group><graduate student><health care-associated infections><healthcare-associated infections><hip arthroplasty><hip joint replacement><hip replacement><hip replacement arthroplasty><hydrophilicity><implant device><implant material><implantable device><improved><indwelling device><innovate><innovation><innovative><insight><ionization><liquid><mechanic><mechanical><mechanical properties><medical implant><polymer><polymeric><post-doc><post-doctoral><post-doctoral trainee><pressure><programs><repair><repaired><research associates><resection><response><side effect><social role><success><undergrad><undergraduate><undergraduate student><vapor><virtual><wound healing><wound resolution>
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Julianne H. Grose

BRIGHAM YOUNG UNIVERSITY, PROVO, UT

Exploratory lead · 0/100
$113,625
FY 2022

Project Title

Investigating the regulation of central metabolism as key to human health and disorders through the association of PASK, USF1 and ATXN2 with phenotypes and disorders in the All of Us database

Grant Number:

3R15GM100376-03A1S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2012

End Date:

8/31/2024

Project Abstract

Metabolic dysregulation lies at the heart of most disorders, from hyperlipidemia and diabetes to cancer and neurodegenerative disorders. Sensory protein kinases, which sense cellular metabolites and regulate metabolism accordingly, lie at the heart of metabolic homeostasis. PAS kinase (PASK) is a nu...

Research Terms

<ATP-protein phosphotransferase><Adult-Onset Diabetes Mellitus><Affect><Alleles><Allelomorphs><Anabolism><Apoplexy><Autoregulation><Blood Glucose><Blood Sugar><Brain Vascular Accident><COVID disease severity><COVID severity><COVID-19><COVID-19 disease severity><COVID-19 predisposition><COVID-19 severity><COVID-19 susceptibility><COVID-19 vulnerability><COVID19><COVID19 disease severity><COVID19 severity><CV-19><CV19><Cancers><Carbon><Cardiac infarction><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cause of Death><Cell Body><Cell Respiration><Cells><Cellular Respiration><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Coronary Disease><Coronary heart disease><Coronavirus disease 2019 predisposition><Coronavirus disease 2019 susceptibility><Coronavirus disease 2019 vulnerability><D-Glucose><Data><Data Bases><Data Set><Databases><Dataset><Degenerative Neurologic Diseases><Degenerative Neurologic Disorders><Development><Dextrose><Diabetes Mellitus><Diet><Disease><Disorder><Electronic Health Record><Exercise><Fats><Fatty acid glycerol esters><Foundations><Genes><Glucose><Goals><Health><Heart><Heart Vascular><Homeostasis><Human><Humulin R><Hyperlipemia><Hyperlipidemia><Individual><Informatics><Insulin><Intermediary Metabolism><Ketosis-Resistant Diabetes Mellitus><Kinase Family Gene><Link><Lipids><Liver><MLTF><Major Late Transcription Factor><Malignant Neoplasms><Malignant Tumor><Maturity-Onset Diabetes Mellitus><Measures><Medical Research><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic Pathway><Metabolic Processes><Metabolism><Mice><Mice Mammals><Modern Man><Molecular><Murine><Mus><Myocardial Infarct><Myocardial Infarction><NIDDM><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Novolin R><Obesity><Outcome><PAS kinase><PI 3-kinase-associated serine kinase><Pathway interactions><Pattern><Phenotype><Physiological Homeostasis><Population><Predisposed to COVID-19><Predisposed to SARS-CoV-2><Predisposed to Severe acute respiratory syndrome coronavirus 2><Predisposition><Prevention><Principal Component Analyses><Principal Component Analysis><Production><Protein Kinase><Proteins><Race><Racial Group><Racial Stocks><Regular Insulin><Regulation><Resistance><Respiration><Risk Factors><Role><SARS-CoV-2 disease severity><SARS-CoV-2 predisposition><SARS-CoV-2 severity><SARS-CoV-2 susceptibility><SARS-CoV-2 vulnerability><SCA2 protein><Sensory><Severe acute respiratory syndrome coronavirus 2 predisposition><Severe acute respiratory syndrome coronavirus 2 susceptibility><Severe acute respiratory syndrome coronavirus 2 vulnerability><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Stroke><Survey Instrument><Surveys><Susceptibility><System><T2 DM><T2D><T2DM><Thesaurismosis><Triacylglycerol><Triglyceride Metabolism><Triglycerides><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><USF1><USF1 gene><United States><Upstream Stimulatory Factor 1><Variant><Variation><Weight><Yeasts><adipogenesis><adiposity><admixture mapping><adult onset diabetes><aerobic metabolism><aerobic respiration><ataxin-2><atherosclerotic heart disease><base><biosynthesis><brain attack><cardiac infarct><cerebral vascular accident><cerebrovascular accident><circulatory system><corona virus disease 2019><coronary attack><coronary disorder><coronary infarct><coronary infarction><coronavirus disease 2019><coronavirus disease 2019 disease severity><coronavirus disease 2019 severity><coronavirus disease severity><coronavirus disease-19><coronavirus infectious disease-19><corpulence><data base><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><detection of nutrient><developmental><diabetes><diets><electronic health care record><electronic healthcare record><entire genome><fitbit><full genome><genome sequencing><glycogen synthase a kinase><heart attack><heart infarct><heart infarction><hepatic body system><hepatic organ system><human disease><hydroxyalkyl protein kinase><ketosis resistant diabetes><lipid biosynthesis><lipogenesis><malignancy><maturity onset diabetes><metabolic rate><metabolism disorder><neoplasm/cancer><neurodegenerative illness><nutrient sensing><oxidative metabolism><pathway><perception of nutrients><phenome><phenotypic data><phosphatidylinositol 3'-kinase-associated serine kinase><phosphorylase b kinase kinase><predisposed to Coronavirus disease 2019><rare allele><rare variant><research study><resistant><respiratory><respiratory mechanism><severe acute respiratory syndrome coronavirus 2 disease severity><severe acute respiratory syndrome coronavirus 2 severity><social role><spinocerebellar ataxia type 2 gene product><sugar><susceptible to COVID-19><susceptible to Coronavirus disease 2019><susceptible to SARS-CoV-2><susceptible to Severe acute respiratory syndrome coronavirus 2><type 2 DM><type II DM><type two diabetes><western diet><western-style diet><western-type diet><whole genome>
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Adam Michael Reitzel

UNIVERSITY OF NORTH CAROLINA CHARLOTTE, CHARLOTTE, NC

Exploratory lead · 0/100
$110,251
FY 2022

Project Title

Environmental and Genetic Determinants of Dynamics in Gene Body Methylation

Grant Number:

3R15GM137253-01S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2020

End Date:

5/31/2024

Project Abstract

PROJECT SUMMARY/ABSTRACT The major objective of this Academic Research Enhancement Award (AREA) R15 project is to determine the combinatory roles for environment and genetics for gene body methylation. The study of epigenetics, particularly methylation, has emphasized that chemical and physical modi...

Research Terms

<Academic Research Enhancement Awards><Acclimation><Acclimatization><Actiniaria><Address><Aging><Animals><Cancers><Chemicals><Cnidaria><Cnidarians><Coelenterata><Cytosine><DNA Methylation><DNA Methyltransferase><DNA Modification><DNA Modification Methylases><DNA Modification Methyltransferases><DNA Modification Process><DNA Structure><DNA-Methyltransferases><Degenerative Neurologic Diseases><Degenerative Neurologic Disorders><Dnmt><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exons><Generations><Genes><Genetic><Genetic Determinism><Genome><Genomics><Health><Human><Individual><Insecta><Insects><Insects Invertebrates><Intervening Sequences><Introns><Invertebrata><Invertebrates><Knowledge><Malignant Neoplasms><Malignant Tumor><Marine Invertebrates><Metabolic Diseases><Metabolic Disorder><Methylation><Modeling><Modern Man><Modification><Modification Methylases><Molecular><N vectensis><N. vectensis><Nematostella><Nematostella vectensis><Nervous System Degenerative Diseases><Nervous System Physiology><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neurologic function><Neurological function><Parents><Physiologic><Physiological><Physiology><Population><Predisposition><R15 Mechanism><R15 Program><Regulation><Research><Role><Sea Anemones><Site-Specific DNA-methyltransferase><Susceptibility><Thesaurismosis><Variant><Variation><cnidocyte><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><epigenome><gene manipulation><genetic determinant><genetic manipulation><genetically manipulate><genetically perturb><genomic biomarker><genomic marker><improved><malignancy><metabolism disorder><neoplasm/cancer><nervous system function><neurodegenerative illness><offspring><physiologic stresses><physiologic stressor><physiological stresses><response><social role><stressor><transgenerational epigenetic inheritance><transgenerational inheritance>
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Ashutosh Tiwari

MICHIGAN TECHNOLOGICAL UNIVERSITY, HOUGHTON, MI

Exploratory lead · 0/100
$100,000
FY 2023

Project Title

Are all Protein Aggregates Toxic?

Grant Number:

3R15GM148964-01S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/22/2022

End Date:

8/31/2025

Project Abstract

This application is in response to NOSI (NOT-GM-22-017) to acquire a Circular Dichroism Spectropolarimeter as part of an administrative supplement. PI has an active eligible R15 grant (1 R15GM148964-01) with enough remaining time to proceed with a supplement request. Currently, Michigan Tech does no...

Research Terms

<Address><Administrative Supplement><Biochemical><Biophysics><Chromatography><Circular Dichroism><Eligibility><Eligibility Determination><Fluorescence><Funding><Grant><Methods><Michigan><Property><Protocol Screening><Research><Secondary Protein Structure><Structure><Techniques><Time><Toxic effect><Toxicities><biophysical foundation><biophysical principles><biophysical sciences><insoluble aggregate><instrument><protein aggregate><protein aggregation><response>
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MIHAELA R MIHAILESCU

DUQUESNE UNIVERSITY, PITTSBURGH, PA

Exploratory lead · 0/100
$100,000
FY 2023

Project Title

Biochemical characterization of a novel Fragile X Mental Retardation Protein nuclease function

Grant Number:

3R15GM127307-05S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2005

End Date:

8/31/2025

Project Abstract

Project Summary Fragile X mental retardation syndrome is the most common form of inherited mental impairement, affecting ~ 1 in 4000 males and ~ 1 in 6000 females. The syndrome is caused by the loss of a normal cellular protein, named the fragile X mental retardation protein (FMRP), which is an RNA ...

Research Terms

<2019 novel corona virus><2019 novel coronavirus><2019-nCoV><Active Sites><Affect><Biochemical><Biogenesis><Biological Function><Biological Process><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 genome><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 public health crisis><COVID-19 virus><COVID-19 virus genome><COVID19 crisis><COVID19 epidemic><COVID19 genome><COVID19 global health crisis><COVID19 global pandemic><COVID19 health crisis><COVID19 pandemic><COVID19 public health crisis><COVID19 virus><COVID19 virus genome><CoV-2><CoV2><DNA><Deoxyribonucleic Acid><Dimerization><Escalante syndrome><FMR-1 Protein><FMR1><FMR1 Gene><FMR1 Protein><FMRP protein><FRAXA><FXR1><FXR1 gene><FXR1P><FXR2><FXR2 gene><FXR2P><Female><Fluorescence Spectroscopy><Fragile X><Fragile X Mental Retardation 1 Gene><Fragile X Mental Retardation Protein><Fragile X Mental Retardation, Autosomal Homolog 1><Fragile X Mental Retardation, Autosomal Homolog 2><Fragile X Syndrome><Fragile X-Related Protein 1><G-Quadruplex><G-Quadruplexes DNA><G-Quartet Structures><G-Quartets><G-Tetrads><G4-DNA><Genome><Hereditary><Hybrids><Immune response><Immunological response><Inherited><Investigation><K Homology Domain><KH Domain><Kinetics><Martin-Bell Syndrome><Martin-Bell-Renpenning syndrome><Messenger RNA><Micro RNA><MicroRNAs><Names><Non-Polyadenylated RNA><Origin of Life><Parents><Peptide Domain><Play><Point Mutation><Process><Property><Protein Dimerization><Protein Domains><Proteins><Psyche structure><RNA><RNA Gene Products><RNA-Binding Proteins><Renpenning syndrome 2><Ribonucleic Acid><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 epidemic><SARS-CoV-2 genome><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-CoV2><SARS-CoV2 epidemic><SARS-CoV2 genome><SARS-CoV2 pandemic><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Severe acute respiratory syndrome related corona virus 2><Syndrome><System><Tertiary Protein Structure><Testing><Translational Regulation><UTRs><Untranslated Regions><Viral><Virus><Wuhan coronavirus><X-linked mental deficiency-megalotestes syndrome><X-linked mental retardation with fragile X syndrome><X-linked mental retardation-fragile site 1 syndrome><anti-viral development><anti-viral drug development><anti-viral therapeutic development><anti-viral therapy development><antiviral development><antiviral drug development><antiviral therapeutic development><antiviral therapy development><autism-fragile X (AFRAX) syndrome><corona virus disease 2019 epidemic><corona virus disease 2019 pandemic><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 genome><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease 2019 virus><coronavirus disease 2019 virus genome><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><coronavirus disease-19 virus><developing anti-viral agent><developing anti-viral drug><developing anti-viral therapeutic><developing anti-viral therapy><developing antiviral agent><developing antiviral drug><developing antiviral therapeutic><developing antiviral therapy><experiment><experimental research><experimental study><experiments><fra(X) syndrome><fra(X)(28) syndrome><fra(X)(q27) syndrome><fra(X)(q27-28) syndrome><fragile X FMR1 protein><fragile X mental retardation 1><fragile X mental retardation-1 protein><fragile X-mental retardation syndrome><fragile X-related protein 2><fragile Xq syndrome><fragile site mental retardation 1><hCoV19><host response><immune system response><immunoresponse><mRNA><macro-orchidism-marker X (MOMX) syndrome><macro-orchidism-marker X syndrome><male><mar(X) syndrome><marker X syndrome><mental><mental retardation-macroorchidism syndrome><miRNA><miRNAs><nCoV2><name><named><naming><novel><nuclease><paralog><paralogous gene><parent><protein function><severe acute respiratory syndrome coronavirus 2 genome><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><social role><stem><success>
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Farhan H Chowdhury

SOUTHERN ILLINOIS UNIVERSITY CARBONDALE, CARBONDALE, IL

Exploratory lead · 0/100
$99,947
FY 2022

Project Title

Single-molecule approaches to study epiblast stem cell fate decision

Grant Number:

3R15GM140448-01A1S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2021

End Date:

6/30/2025

Project Abstract

PROJECT SUMMARY An equipment supplement award for 1R15GM140448-01 (Title: Single-molecule approaches to study epiblast stem cell fate decision) is requested to acquire Leica’s THUNDER imager live cell and 3D assay system. Exploiting the advances in the computational clearing feature in real-time, th...

Research Terms

<3-D><3-Dimensional><3D><Assay><Award><Binding><Bioassay><Biologic Assays><Biological Assay><Cell Body><Cell Communication><Cell Fate Control><Cell Fate Regulation><Cell Interaction><Cell-to-Cell Interaction><Cells><Complex><Engineering><Epiblast><Equipment><Funding><Goals><Grant><Knowledge><Molecular><Molecular Interaction><Progenitor Cells><Regenerative Medicine><Research><Science><System><Time><Tissue Engineering><bioengineered tissue><career><cell type><engineered tissue><graduate student><imager><single molecule><stem cell fate><stem cells><three dimensional><training opportunity><undergrad><undergraduate><undergraduate student>
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Mi Hye Song

OAKLAND UNIVERSITY, ROCHESTER, MI

Exploratory lead · 0/100
$99,900
FY 2023

Project Title

Administrative Supplements for Equipment Purchases

Grant Number:

3R15GM147857-01S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2022

End Date:

8/31/2025

Project Abstract

Project Summary Under the current NIGMS R15 research award (1R15GM147857-01), this proposal requests supplemental equipment funds that will be used to replace an old broken Odyssey Infrared Imaging system. The parent project focuses on the Proteolytic Regulation of Centrosome Proteins. The requested...

Research Terms

<26 S proteasome complex><26S ATP-Dependent Protease><26S ATP-Dependent Proteasome><26S Proteasome Complex><26S Proteosome><26S protease><26S proteasome><Administrative Supplement><Affect><Autoregulation><Award><Biochemical><Biologic Models><Biological Models><Biology><Brain><Brain Nervous System><C elegans><C. elegans><C.elegans><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Caenorhabditis elegans><Cancers><Cas nuclease technology><Cell Communication and Signaling><Cell Cycle><Cell Division Cycle><Cell Signaling><Cell division><Centrioles><Centrosome><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Compensation><Defect><Detection><Development><Disease><Disorder><E3 Ligase><E3 Ubiquitin Ligase><Embryo><Embryonic><Encephalon><Ensure><Equipment><Exhibits><Funding><Genetic><Genetic Alteration><Genetic Change><Genetic defect><Genome Instability><Genomic Instability><Goals><Healthcare><Homeostasis><Human><Intracellular Communication and Signaling><Knowledge><MTOC><Malignant Neoplasms><Malignant Tumor><Measurement><Mediating><Mice><Mice Mammals><Microcephaly><Microtubule-Organizing Center><Model System><Modern Man><Murine><Mus><Mutation><NIGMS><National Institute of General Medical Sciences><Oncogenesis><Parents><Physiological Homeostasis><Predisposition><Protein Analysis><Protein Cleavage><Proteins><Proteolysis><Proteolytic Regulation><Quantitative Microscopy><Regulation of Proteolysis><Request for Proposals><Research><Resolution><Role><Signal Transduction><Signal Transduction Systems><Signaling><Susceptibility><System><Testing><Therapeutic Intervention><Transmission><Ubiquitin Ligase Component Gene><Ubiquitin Ligase Gene><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Work><anaphase-promoting complex><biological signal transduction><ciliopathy><cyclosome><daughter cell><developmental><equipment acquirement><equipment acquisition><equipment investment><equipment procurement><equipment purchase><equipment purchasing><genome editing><genome integrity><genome mutation><genomic editing><genomic integrity><health care><human disease><imaging system><in vivo><in vivo Model><instrument acquisition><instrument investment><instrument procurement><instrument purchase><intervention therapy><malignancy><micrencephaly><microencephaly><mutant><nano><neoplasm/cancer><parent><parent project><recruit><resolutions><social role><success><transmission process><tumorigenesis><ubiquitin ligase><ubiquitin-protein ligase>
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Donald Eric Spratt

CLARK UNIVERSITY (WORCESTER, MA), WORCESTER, MA

Exploratory lead · 0/100
$98,045
FY 2023

Project Title

Structure and Mechanism of HERC5-dependent ISGylation

Grant Number:

3R15GM126432-02S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/20/2017

End Date:

3/31/2025

Project Abstract

Project Summary Mammalian cells have developed an elaborate network of immunoproteins that serve to identify and combat viral pathogens. Interferon-stimulated gene 15 (ISG15) is a 17.2 kDa tandem ubiquitin-like protein that is used by specific E1– E2–E3 ubiquitin cascade enzymes to interfere with th...

Research Terms

<2019 novel corona virus><2019 novel coronavirus><2019-nCoV><3-D structure><3-dimensional structure><3D structure><8 year old><8 years of age><AIDS Virus><APF-1><ATP-Dependent Proteolysis Factor 1><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Active Sites><Authorship><Biochemical><Biochemistry><Biological Chemistry><C-terminal><COVID-19 virus><COVID19 virus><Cell Communication and Signaling><Cell Signaling><Characteristics><CoV-2><CoV2><Complex><Cysteine><DNA Molecular Biology><Development><Disease><Disorder><Dysfunction><E3 Ligase><E3 Ubiquitin Ligase><E6AP><Enzymatic Biochemistry><Enzyme Gene><Enzymes><Enzymology><Equipment><FPLC><Functional disorder><Future><Genes><Goals><Grippe><HCV infection><HIV><HMG-20><Half-Cystine><Health><Hepatitis C><Hepatitis C virus infection><Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted><Hepatitus C><High Mobility Protein 20><Human><Human Immunodeficiency Viruses><IFN><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologics><Influenza><Innate Immune Response><Interferons><International><Intracellular Communication and Signaling><L-Cysteine><LAV-HTLV-III><Learning><Lobe><Lymphadenopathy-Associated Virus><Mammalian Cell><Manuscripts><Modern Man><Molecular><Molecular Biology><N-terminal><NH2-terminal><NMR Spectrometer><NMR Spectroscopy><Physiopathology><Preparation><Proteins><Publications><R-Series Research Projects><R01 Mechanism><R01 Program><Reporting><Research><Research Grants><Research Project Grants><Research Projects><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Scientific Publication><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Signal Transduction><Signal Transduction Systems><Signaling><Structure><System><TM Pharmacia Fast Protein Liquid Chromatography><UBE3A><UBE3A gene><Ubiquitin><Ubiquitin Like Proteins><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Ubiquitin-Protein Ligase E3A><Universities><Viral><Viral Activity><Viral Diseases><Viral Function><Viral Gene Products><Viral Gene Proteins><Viral Physiology><Viral Proteins><Virus Diseases><Virus-HIV><Work><Wuhan coronavirus><age 8 years><biological signal transduction><biophysical approaches><biophysical methodology><biophysical methods><biophysical techniques><combat><conference><convention><coronavirus disease 2019 virus><coronavirus disease-19 virus><develop therapy><developmental><eight year old><eight years of age><fast protein liquid chromatography><hCoV19><hep C><hepatitis non A non B><improved><infection by hepatitis c virus><insight><intervention development><lobes><member><nCoV2><non A, non B hepatitis><non-A, non-B hepatitis><novel><nuclear magnetic resonance spectroscopy><pathogenic virus><pathophysiology><preparations><programs><response><social role><success><summit><symposia><symposium><therapy development><three dimensional structure><treatment development><ubiquitin-protein ligase><undergrad><undergraduate><undergraduate student><viral infection><viral pathogen><virus infection><virus pathogen><virus protein><virus-induced disease>
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Aukje Lamonica

SOUTHERN CONNECTICUT STATE UNIVERSITY, NEW HAVEN, CT

Exploratory lead · 0/100
$91,242
FY 2022

Project Title

SOS PrOMPT: Suburban Opioid Study- Providing for Opioid-using Mothers and Pregnant Women who need Treatment

Grant Number:

3R15DA041657-02S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2017

End Date:

8/31/2023

Project Abstract

Project Summary/Abstract The broad goal of the parent R15 Academic Research Enhancement Award (AREA) study is to gain a more in-depth understanding of the lived experiences of suburban women who use opioids while they are pregnant or caring for children 12 years old and younger. The number of mother...

Research Terms

<0-11 years old><12 year old><12 years of age><Academic Research Enhancement Awards><Access to Care><Address><Age><Attention><COVID><COVID-19><COVID19><CV-19><CV19><Child><Child Care><Child Youth><Children (0-21)><Clinic><CoV disease><Connecticut><Data Collection><Ethnography><Family><Female><Goals><Health><Health Resources><Health Services><Health Services Accessibility><Healthcare Delivery><Interview><Investigators><Knowledge><Longitudinal Studies><Methods><Minority Female><Minority Women><Mothers><Needle-Exchange Programs><New Jersey><Opiates><Opioid><Outcome><Parents><Persons><Policies><Policy Developments><Pregnant Women><Puericulture><R15 Mechanism><R15 Program><Research><Research Personnel><Research Resources><Researchers><Resources><Risk Behaviors><Risky Behavior><SOS><SOS Proteins><SOS exchange factor><Sampling><Site><Social Service><Social Work><Social isolation><Son of Sevenless Proteins><Substance Use Disorder><Survey Instrument><Surveys><Syringe-Exchange Programs><Training><Woman><access to health services><access to services><access to treatment><accessibility to health services><age 12 years><ages><at risk behavior><availability of services><care access><career development><corona virus disease><corona virus disease 2019><coronavirus disease><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><coronavirus of pandemic concern><coronavirus of pandemic potential><coronavirus with pandemic potential><disadvantaged background><ethnographic><expectant mother><expecting mother><experience><health care delivery><health care service><health delivery systems><health service access><health services availability><health services delivery><healthcare service><long-term study><longitudinal outcome studies><longterm study><medication-assisted therapy><medication-assisted treatment><needle exchange><opiate consumption><opiate drug use><opiate intake><opiate use><opioid consumption><opioid drug use><opioid intake><opioid use><pandemic coronavirus><pandemic threat coronavirus><parent grant><pregnant><pregnant mothers><public health relevance><service availability><skills><social science research><son of sevenless protein><substance use><substance using><suburb><suburban><suburbia><syringe exchange><syringe exchange services><syringe service programs><treatment access><twelve year old><twelve years of age><youngster>
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Ling Wang

EAST TENNESSEE STATE UNIVERSITY, JOHNSON CITY, TN

Exploratory lead · 0/100
$82,400
FY 2023

Project Title

Transcriptional Activation of p62 by the master antioxidant NRF2 in EBV latency

Grant Number:

3R15CA252986-01A1S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2023

End Date:

7/31/2024

Project Abstract

Project Summary EBV infection is associated with a panel of diseases and cancers, and serves as a fascinating paradigm for the study of host-virus interactions. Oxidative stress is essential for virus-mediated oncogenesis, and for EBV transformation of B cells. Reactive oxygen species (ROS) are inde...

Research Terms

<AIDS associated cancer><AIDS related cancer><AIDS-Related Malignancy><AIDS-Related Malignant Neoplasm><AIDS-associated malignancies><AP-1><AP-1 Enhancer-Binding Protein><AP1><AP1 protein><Activator Protein-1><Active Oxygen><Address><Aging><Antioxidants><Autophagocytosis><Autoregulation><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Basal Transcription Factor><Basal transcription factor genes><Biochemistry and Cellular Biology><Biomedical Research><Bp50><Burkitt Herpesvirus><Burkitt Lymphoma Virus><CD40><CDW40><Cancer Biology><Cancers><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Function><Cell Line><Cell Process><Cell Signaling><Cell Survival><Cell Viability><Cell physiology><CellLine><Cellular Function><Cellular Physiology><Cellular Process><Cessation of life><Clinical><DNA Damage><DNA Injury><Death><Development><Disease><Disorder><EB virus><EBV><EBV Infections><EBV latency><EBV-associated disease><Enhancer-Binding Protein AP1><Epithelial Cells><Epstein Barr Virus><Epstein-Barr Virus Infections><Epstein-Barr Virus associated disease><Epstein-Barr Virus latency><Epstein-Barr pathogenesis><Epstein-Barr viral infections><Equilibrium><Experimental Designs><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genetic Transcription><Germinoblastic Sarcoma><Germinoblastoma><Goals><HHV-4><HHV4><HIV-Associated Cancer><HIV-associated malignancy><HIV-related malignancy><HIV/AIDS-associated malignancy><HIV/AIDS-related cancer><Homeostasis><Human Herpesvirus 4><I Kappa B A><I Kappa B-Alpha><I kappa B-alpha protein><IKB-Alpha><IKappaB><IKappaB-Alpha><IKappaB/MAD-3><IkappaBalpha><Image><Immunity><Immunology><Infection Control><Infectious Mononucleosis Virus><Inflammation><Intracellular Communication and Signaling><IκBα><Kinases><LMP1><Latent virus infection phase><Left><Lymphoid Cell><Lymphoma><Lytic><MAD-3 protein><MAD3><MAD3 inhibitor><MGC9013><Maintenance><Major Histocompatibility Complex Enhancer-Binding Protein MAD3><Malignant Lymphoma><Malignant Neoplasms><Malignant Tumor><Mediating><Mitochondria><Modeling><Molecular and Cellular Biology><NF-Kappa B Inhibitor Alpha><NF-kappaB inhibitor alpha><Nuclear Factor Kappa-B Inhibitor><Nuclear Factor of Kappa Light Chain Gene Enhancer in B Cells Inhibitor><Nuclear Factor of Kappa Light Chain Gene Enhancer in B Cells Inhibitor, Alpha><Obesity><Oncogenesis><Outcome><Oxidation-Reduction><Oxidative Stress><Oxygen Radicals><Parents><Pathogenesis><Pathway interactions><Patients><Phosphorylation><Phosphotransferase Gene><Phosphotransferases><Physiological Homeostasis><Pro-Oxidants><Problem Solving><Process><Production><Property><Protein Phosphorylation><Publications><Publishing><Quantitative Evaluations><RNA Expression><Reactive Oxygen Species><Redox><Reticulolymphosarcoma><Role><Scientific Publication><Series><Signal Transduction><Signal Transduction Systems><Signaling><Strains Cell Lines><Students><Subcellular Process><TNF Receptor-Associated Factor 6 Gene><TNFRSF5><TNFRSF5 gene><TRAF6><TRAF6 gene><Techniques><Testing><Therapeutic><Thinking><Time><Training><Transcription><Transcription Activation><Transcription Factor AP-1><Transcription Factor Proto-Oncogene><Transcription factor genes><Transcriptional Activation><Transphosphorylases><Tumor Necrosis Factor Receptor Superfamily Member 5 Gene><Viral><Viral Pathogenesis><Virus><Writing><adiposity><anti-oxidant><autophagy><balance><balance function><bio-imaging><bioimaging><biological signal transduction><cell transformation><corpulence><cultured cell line><design><designing><developmental><fascinate><flow cytophotometry><imaging><improved><interest><latent viral infection><latent virus infection><malignancy><mitochondrial><neoplasm/cancer><neurotrophic factor><neurotrophin><neutrophin><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><osteoclastogenesis><oxidation reduction reaction><p50><p65><parent><parent project><pathogen><pathogenesis of Epstein-Barr virus><pathogenesis of Epstein-Barr virus infection><pathway><response><social role><student training><thoughts><transcription factor><transformed cells><transforming virus><tumorigenesis><virus host interaction><virus pathogenesis>
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ERIKA Ann MONTANARO

UNIVERSITY OF NORTH CAROLINA CHARLOTTE, CHARLOTTE, NC

Exploratory lead · 0/100
$77,236
FY 2022

Project Title

Exploring how bystanders' own intoxication influences their ability to intervene appropriately

Grant Number:

3R15AA028910-01S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2022

End Date:

7/31/2024

Project Abstract

Abstract The current diversity supplement extends the aims of the parent grant (R15AA028910). The parent grant is a 3-year R15 AREA project designed to create the novel Bystander Intervention for Problematic Alcohol Use Measure (BIPAUM), with specific aims to 1) develop the measure and establish th...

Research Terms

<Active Follow-up><Address><African American><Afro American><Afroamerican><Agreement><Alcohol Chemical Class><Alcohol Drinking><Alcohol Intoxication><Alcohol abuse><Alcohol consumption><Alcoholic><Alcoholic Intoxication><Alcohols><Arabs><Area><Asian Americans><Attitude><Behavior><Black><Black race><Boozer><Code><Coding System><Coercion><Color><Communication><Consent><Consumption><Data Analyses><Data Analysis><Dependent drinker><Development><Drunkenness><EtOH abuse><EtOH drinking><EtOH intoxication><EtOH use><Event><Feedback><Focus Groups><Gender><Gender and Sexual Minorities><Goals><Grant><Greek><Health><Intervention><Intervention Strategies><Intoxication><Jasmine><Jasminum><Knowledge><Latinx><Lead><Life><Literature><Manuscripts><Measures><Mental Health><Mental Hygiene><Mentorship><Methodology><Methods><Mind><Modeling><Outcome><Parents><Pb element><Perception><Persons><Process><Property><Psychological Health><Psychometrics><Race><Racial Group><Racial Stocks><Research><Risk><Risk Assessment><Scientist><Sex Behavior><Sex Orientation><Sexual Activity><Sexual Behavior><Sexual Orientation><Sexual and Gender Minorities><Students><Training><Transcript><Update><Validation><Woman><Writing><active followup><alcohol co-abuse><alcohol ingestion><alcohol intake><alcohol intervention><alcohol involvement><alcohol problem><alcohol product use><alcohol use><alcoholic beverage consumption><alcoholic drink intake><assaulted sexually><college student><conference><convention><data interpretation><design><designing><developmental><drinking><ethanol abuse><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol intoxication><ethanol product use><ethanol use><ethnic minority><ethnoracial><experience><follow up><follow-up><followed up><followup><gender minority><hazardous alcohol use><heavy metal Pb><heavy metal lead><improved><initiation of sexual activity><interest><intervention design><intervention program><interventional strategy><involvement with alcohol><member><men><men's><minority student><novel><parent grant><physical conditioning><physical health><pre-doc><pre-doctoral><predoc><predoctoral><prevent><prevent violence><preventing><problem alcohol use><problem drinker><problem drinking><problematic alcohol consumption><problematic alcohol use><programs><racial and ethnic><response><sex activity><sexual assault><sexual attack><sexual debut><sexual initiation><sexual minority><sexual violence><skills><summit><symposia><symposium><therapy design><treatment design><university student><violence prevention>
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Annelise Mennicke

UNIVERSITY OF NORTH CAROLINA CHARLOTTE, CHARLOTTE, NC

Exploratory lead · 0/100
$77,236
FY 2022

Project Title

Exploring how bystanders' own intoxication influences their ability to intervene appropriately

Grant Number:

3R15AA028910-01S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2022

End Date:

7/31/2024

Project Abstract

Abstract The current diversity supplement extends the aims of the parent grant (R15AA028910). The parent grant is a 3-year R15 AREA project designed to create the novel Bystander Intervention for Problematic Alcohol Use Measure (BIPAUM), with specific aims to 1) develop the measure and establish th...

Research Terms

<Active Follow-up><Address><African American><Afro American><Afroamerican><Agreement><Alcohol Chemical Class><Alcohol Drinking><Alcohol Intoxication><Alcohol abuse><Alcohol consumption><Alcoholic><Alcoholic Intoxication><Alcohols><Arabs><Area><Asian Americans><Attitude><Behavior><Black><Black race><Boozer><Code><Coding System><Coercion><Color><Communication><Consent><Consumption><Data Analyses><Data Analysis><Dependent drinker><Development><Drunkenness><EtOH abuse><EtOH drinking><EtOH intoxication><EtOH use><Event><Feedback><Focus Groups><Gender><Gender and Sexual Minorities><Goals><Grant><Greek><Health><Intervention><Intervention Strategies><Intoxication><Jasmine><Jasminum><Knowledge><Latinx><Lead><Life><Literature><Manuscripts><Measures><Mental Health><Mental Hygiene><Mentorship><Methodology><Methods><Mind><Modeling><Outcome><Parents><Pb element><Perception><Persons><Process><Property><Psychological Health><Psychometrics><Race><Racial Group><Racial Stocks><Research><Risk><Risk Assessment><Scientist><Sex Behavior><Sex Orientation><Sexual Activity><Sexual Behavior><Sexual Orientation><Sexual and Gender Minorities><Students><Training><Transcript><Update><Validation><Woman><Writing><active followup><alcohol co-abuse><alcohol ingestion><alcohol intake><alcohol intervention><alcohol involvement><alcohol problem><alcohol product use><alcohol use><alcoholic beverage consumption><alcoholic drink intake><assaulted sexually><college student><conference><convention><data interpretation><design><designing><developmental><drinking><ethanol abuse><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol intoxication><ethanol product use><ethanol use><ethnic minority><ethnoracial><experience><follow up><follow-up><followed up><followup><gender minority><hazardous alcohol use><heavy metal Pb><heavy metal lead><improved><initiation of sexual activity><interest><intervention design><intervention program><interventional strategy><involvement with alcohol><member><men><men's><minority student><novel><parent grant><physical conditioning><physical health><pre-doc><pre-doctoral><predoc><predoctoral><prevent><prevent violence><preventing><problem alcohol use><problem drinker><problem drinking><problematic alcohol consumption><problematic alcohol use><programs><racial and ethnic><response><sex activity><sexual assault><sexual attack><sexual debut><sexual initiation><sexual minority><sexual violence><skills><summit><symposia><symposium><therapy design><treatment design><university student><violence prevention>
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Christopher Scott Brower

TEXAS WOMAN'S UNIVERSITY, DENTON, TX

Exploratory lead · 0/100
$72,067
FY 2022

Project Title

Evaluating Protein Quality Control in the Toxicity of TDP43 Fragments Associated with ALS and FTD

Grant Number:

3R15NS095317-02A1S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

1/31/2024

Project Abstract

Project Summary People are living longer, which increases their risk of developing neurodegenerative disorders. Such disorders can be characterized by the accumulation and aggregation of specific proteins in the brain. These aggregates often contain protein fragments produced by increases in protein...

Research Terms

<ALS and FTD><ALS and FTLD><Abscission><Amyotrophic lateral sclerosis and frontotemporal degeneration><Amyotrophic lateral sclerosis and frontotemporal dementia><Amyotrophic lateral sclerosis and frontotemporal lobar dementia><B cell lymphoma 2><B-Cell CLL/Lymphoma 2 Gene><B-cell lymphoma/leukemia-2><BCL2><BCL2 gene><Bcl-2><Brain><Brain Nervous System><Cell Body><Cell Function><Cell Process><Cell physiology><Cells><Cellular Function><Cellular Physiology><Cellular Process><Defect><Degenerative Neurologic Diseases><Degenerative Neurologic Disorders><Disease><Disorder><Encephalon><Excision><Extirpation><FTD/ALS><FTLD-ALS><Goals><Hydrophobicity><Intermediary Metabolism><Mediating><Metabolic Processes><Metabolic Protein Degradation><Metabolism><Morphology><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><Neurons><Normal Cell><Parents><Pathway interactions><Persons><Protein Cleavage><Protein Fragment><Protein Turnover><Proteins><Proteolysis><Quality Control><Regulatory Protein Degradation><Removal><Reporting><Risk><Subcellular Process><Surgical Removal><System><TAR DNA-binding protein 43><TDP-43><TDP43><Toxic effect><Toxicities><Training><Triage><amyotrophic lateral sclerosis and frontotemporal lobar degeneration><amyotrophic lateral sclerosis/ftd><bcl-2 Genes><ced9 homolog><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><frontotemporal lobar dementia-amyotrophic lateral sclerosis><graduate student><insight><insoluble aggregate><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neuronal><neuronal degeneration><novel><pathway><prevent><preventing><protein TDP-43><protein TDP43><protein aggregate><protein aggregation><protein degradation><resection>
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Gerard James Madlambayan

OAKLAND UNIVERSITY, ROCHESTER, MI

Exploratory lead · 0/100
$71,873
FY 2024

Project Title

Purchase of a Benchtop Flow Cytometer

Grant Number:

3R15CA254006-01A1S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/23/2022

End Date:

8/31/2025

Project Abstract

PROJECT SUMMARY OF FUNDED R15 GRANT (R15CA254006-01A1) A major component of many solid tumors, including lung cancers, are bone marrow (BM)-derived immune cells that migrate to tumors and aid in their continued growth. While the activity of these cells including tumor associated macrophages (TAMs) h...

Research Terms

<Blood Precursor Cell><Bone Marrow><Bone Marrow Reticuloendothelial System><Cancers><Cell Body><Cell Communication and Signaling><Cell Growth and Maintenance><Cell Locomotion><Cell Maintenance><Cell Migration><Cell Movement><Cell Signaling><Cell-Extracellular Matrix><Cells><Cellular Migration><Cellular Motility><Data><Development><ECM><Extracellular Matrix><Focal Adhesion Kinase 1><Funding><Generalized Growth><Glycoprotein GP-2><Goals><Growth><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Immune><Immunes><In Vitro><Integrins><Integrins Extracellular Matrix><Intracellular Communication and Signaling><Investigation><Knowledge><Laminin><Macrophage><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Mφ><PTK2 Protein Tyrosine Kinase 2><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Play><Population><Process><Progenitor Cells><Pulmonary Cancer><Pulmonary malignant Neoplasm><Radiation therapy><Radiotherapeutics><Radiotherapy><Recovery><Role><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Solid Neoplasm><Solid Tumor><Testing><Time><Tissue Growth><Tumor Biology><Tumor Promotion><Tumor-associated macrophages><biological signal transduction><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><bone cell><cancer microenvironment><cancer progression><cell motility><developmental><endogenous substrate pp120><focal adhesion kinase><focal adhesion protein tyrosine kinase><focal adhesion-associated protein tyrosine kinase pp125FAK><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><in vivo><lung cancer><malignancy><migration><neoplasm progression><neoplasm/cancer><neoplastic progression><novel><ontogeny><patient oriented outcomes><progenitor cell migration><progenitor migration><radiation treatment><response to therapy><response to treatment><social role><stem cell migration><stem cells><therapeutic response><therapy response><treatment response><treatment responsiveness><treatment strategy><treatment with radiation><tumor><tumor growth><tumor microenvironment><tumor progression>
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Luis Gerardo Villa Diaz

OAKLAND UNIVERSITY, ROCHESTER, MI

Exploratory lead · 0/100
$71,873
FY 2024

Project Title

Purchase of a Benchtop Flow Cytometer

Grant Number:

3R15CA254006-01A1S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/23/2022

End Date:

8/31/2025

Project Abstract

PROJECT SUMMARY OF FUNDED R15 GRANT (R15CA254006-01A1) A major component of many solid tumors, including lung cancers, are bone marrow (BM)-derived immune cells that migrate to tumors and aid in their continued growth. While the activity of these cells including tumor associated macrophages (TAMs) h...

Research Terms

<Blood Precursor Cell><Bone Marrow><Bone Marrow Reticuloendothelial System><Cancers><Cell Body><Cell Communication and Signaling><Cell Growth and Maintenance><Cell Locomotion><Cell Maintenance><Cell Migration><Cell Movement><Cell Signaling><Cell-Extracellular Matrix><Cells><Cellular Migration><Cellular Motility><Data><Development><ECM><Extracellular Matrix><Focal Adhesion Kinase 1><Funding><Generalized Growth><Glycoprotein GP-2><Goals><Growth><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Immune><Immunes><In Vitro><Integrins><Integrins Extracellular Matrix><Intracellular Communication and Signaling><Investigation><Knowledge><Laminin><Macrophage><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Mφ><PTK2 Protein Tyrosine Kinase 2><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Play><Population><Process><Progenitor Cells><Pulmonary Cancer><Pulmonary malignant Neoplasm><Radiation therapy><Radiotherapeutics><Radiotherapy><Recovery><Role><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Solid Neoplasm><Solid Tumor><Testing><Time><Tissue Growth><Tumor Biology><Tumor Promotion><Tumor-associated macrophages><biological signal transduction><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><bone cell><cancer microenvironment><cancer progression><cell motility><developmental><endogenous substrate pp120><focal adhesion kinase><focal adhesion protein tyrosine kinase><focal adhesion-associated protein tyrosine kinase pp125FAK><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><in vivo><lung cancer><malignancy><migration><neoplasm progression><neoplasm/cancer><neoplastic progression><novel><ontogeny><patient oriented outcomes><progenitor cell migration><progenitor migration><radiation treatment><response to therapy><response to treatment><social role><stem cell migration><stem cells><therapeutic response><therapy response><treatment response><treatment responsiveness><treatment strategy><treatment with radiation><tumor><tumor growth><tumor microenvironment><tumor progression>
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YING JIA

UNIVERSITY OF TEXAS RIO GRANDE VALLEY, EDINBURG, TX

Exploratory lead · 0/100
$56,108
FY 2024

Project Title

Identifying the interactions between animal toxins and human nAChRs: the role of snake PLA2 in interacting with nAChR alpha subunits

Grant Number:

3R15NS128563-01S2

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2024

End Date:

12/31/2025

Project Abstract

PROJECT SUMMARY/ABSTRACT Nicotinic acetylcholine receptors (nAChRs) are involved in a variety of fundamental physiological processes, and dysfunction in these receptors is associated with many human disorders. The structure and function of human nAChRs have been extensively studied; however, the com...

Research Terms

<3-D><3-Dimensional><3D><AD dementia><Agonist><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Animals><Bacterial Transformation><Binding><Biochemical><Biology><Biomedical Research><CNS Nervous System><Calcium><Cell Function><Cell Physiology><Cell Process><Cellular Function><Cellular Physiology><Cellular Process><Central Nervous System><Complex><DNA amplification><Detection><Dideoxy Chain Termination DNA Sequencing><Discipline><Disease><Disorder><Dysfunction><EC 3.1.1.4><ELISA><Educational Achievement><Educational Status><Enzyme-Linked Immunosorbent Assay><Epilepsy><Epileptic Seizures><Epileptics><Functional disorder><Funding><Future><Generations><Goals><Health><Human><Institution><Instruction><Investigators><Lead><Learning><Lecithinase A2><Ligands><Maps><Measures><Medical><Membrane Potentials><Modern Man><Molecular><Molecular Biology Techniques><Molecular Interaction><NINDS><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><Natural Selections><Nerve Cells><Nerve Unit><Nervous System><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neuraxis><Neurocyte><Neurologic Body System><Neurologic Disorders><Neurologic Organ System><Neurological Disorders><Neurons><Neurosciences><Neurosciences Research><Nicotine Dependence><Nicotinic Acetylcholine Receptors><Nicotinic Receptors><Obesity><Organism><Organism-Level Process><Organismal Process><Outcome><Over weight><Overweight><PLA2><Palsy><Paper><Paralysed><Paralysis Agitans><Parkinson><Parkinson Disease><Pb element><Peer Review><Phospholipase A2><Physiologic><Physiologic Processes><Physiological><Physiological Processes><Physiopathology><Plegia><Primary Parkinsonism><Primary Senile Degenerative Dementia><Property><Proteins><Publishing><Receptor Protein><Research><Research Activity><Research Personnel><Research Proposals><Researchers><Resting Potentials><Role><Sanger Sequencing><Science><Scientist><Seizure Disorder><Signal Pathway><Snake Venoms><Snakes><Structure><Students><Subcellular Process><Techniques><Toxin><Training><Transmembrane Potentials><Underrepresented Groups><Underrepresented Populations><Venoms><Work><adiposity><antagonism><antagonist><beta2 nicotinic acetylcholine receptor><career><corpulence><design><designing><educational level><empowerment><enzyme linked immunoassay><epilepsia><epileptogenic><experiment><experimental research><experimental study><experiments><extracellular><graduate student><heavy metal Pb><heavy metal lead><lecithinase A><living system><neurological disease><neuron toxicity><neuronal><neuronal toxicity><neurotoxicity><next generation><nicotine addiction><nicotine dependent><nicotinic acetylcholine beta-2 receptor><nicotinic acetylcholine β-2 receptor><nicotinic receptor beta2><nicotinic receptor β2><paralysis><paralytic><pathophysiology><pharmacologic><phosphatidase><phosphatidolipase><phosphatidylcholine 2 acylhydrolase><polypeptide><posters><primary degenerative dementia><programs><receptor><role model><senile dementia of the Alzheimer type><skills><social role><student engagement><student motivation><student participation><three dimensional><tool><training achievement><training level><training status><under representation of groups><under represented groups><under represented people><under represented populations><undergrad><undergraduate><undergraduate student><underrepresentation of groups><underrepresented people><β2 nicotinic acetylcholine receptor>
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Larry D Keen

VIRGINIA STATE UNIVERSITY, PETERSBURG, VA

Exploratory lead · 0/100
$50,520
FY 2024

Project Title

Emma Quarles NIDA Diversity Supplement Proposal

Grant Number:

3R15DA052886-01A1S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2021

End Date:

8/31/2024

Project Abstract

PROJECT SUMMARY Abstract and Aims of Parent Grant. Given the shifts in social perceptions and legalization efforts relating to cannabis use, it is imperative to determine the complex interplay between cannabis use and cardiovascular health. Researchers have identified an association between cannabis...

Research Terms

<21+ years old><Address><Adult><Adult Human><African American><African American group><African American individual><African American people><African American population><African Americans><Afro American><Afroamerican><Award><Biology><Black><Black Populations><Black group><Black individual><Black people><Black race><Blacks><Brain><Brain Nervous System><Cannabis><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Clinical><Clinical Research><Clinical Sciences><Clinical Study><Cognition><Cognition Therapy><Cognitive Discrimination><Cognitive Psychotherapy><Cognitive Therapy><Cognitive treatment><Communities><Complex><Data><Data Analyses><Data Analysis><Development><Discrimination><Disease><Disorder><ECG><EKG><Electrocardiogram><Electrocardiography><Encephalon><Epidemiology><Event><Frequencies><Funding><HBCUs><Health><Heart><Heart Vascular><Historically Black Colleges><Historically Black Colleges and Universities><Historically Black Institution><Historically Black University><Hour><Individual><International><Intervention><Intervention Strategies><Interview><Investigators><Legal><Link><Literature><Manuscripts><Measurement><Measures><Mentors><Mentorship><NIDA><NIH><National Institute of Drug Abuse><National Institute on Drug Abuse><National Institutes of Health><Neuranatomies><Neuranatomy><Neuroanatomies><Neuroanatomy><Neuropsychologies><Neuropsychology><Parents><Participant><Patient Self-Report><Phase><Physiologic><Physiological><Pilot Projects><Postbaccalaureate><Preparation><Prevalence><Preventative strategy><Prevention strategy><Preventive strategy><Process><Psychology><Psychopathology><Publishing><Reporting><Research><Research Personnel><Research Resources><Researchers><Resources><Rest><SAMHSA><Sampling><Self-Report><Social Perception><Stress><Students><Substance Abuse and Mental Health Services Administration><THC co-use><THC use><Testing><Tetrahydrocannabinol co-use><Tetrahydrocannabinol use><Training><United States><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><United States National Institutes of Health><United States Substance Abuse and Mental Health Services Administration><Universities><Virginia><abnormal psychology><adult youth><adulthood><cannabis use><cannabis use disorder><cannabis user><cardiac rhythm><cardiovascular health><circulatory system><clinical center><cognitive behavior intervention><cognitive behavior modification><cognitive behavior therapy><cognitive behavioral intervention><cognitive behavioral modification><cognitive behavioral therapy><cognitive behavioral treatment><cognitive process><data interpretation><developmental><epidemiologic><epidemiological><experience><graduate school><heart rate variability><heart rhythm><human subject><innovate><innovation><innovative><intervention program><interventional strategy><marijuana use><marijuana use and disorder><marijuana use disorder><marijuana user><meeting><meetings><neuropsychiatric><neuropsychiatry><neuropsychologic><parent><parent grant><pilot study><postbac><postbacc><preparations><programs><psychosocial><psychosocial stresses><psychosocial stressors><screening><screenings><statistics><stressor><substance use><substance using><tool><treatment strategy><vigilance><young adult><young adulthood>
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Shijie Zhou

MIAMI UNIVERSITY OXFORD, OXFORD, OH

Exploratory lead · 0/100
$44,057
FY 2023

Project Title

Development of an automatic real-time personalized non-invasive localization of the site of origin of the earliest ventricular activation

Grant Number:

1R15HL167222-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2023

End Date:

8/22/2024

Project Abstract

Project Summary Sudden cardiac arrest is one of the leading causes of death in developed countries, accounting for approximately 350,000 deaths per year in the United States. The majority of those events are caused by ventricular arrhythmias (VA). Implantable defibrillators reduce mortality in high...

Research Terms

<3-D><3-Dimensional><3D><Ablation><Academic Research Enhancement Awards><Accounting><Arrhythmia><Asystole><Biomedical Engineering><Body Tissues><CAT scan><CT X Ray><CT Xray><CT imaging><CT scan><Cardiac><Cardiac Arrest><Cardiac Arrhythmia><Cardiac Diseases><Cardiac Disorders><Cardiac Electrophysiologic Techniques><Cardiac Electrophysiological Diagnostics><Cardiac ablation><Case Series><Catheter Ablation><Catheters><Cause of Death><Cessation of life><Clinical><Clinical Data><Computed Tomography><Computer software><Data><Data Set><Death><Developed Countries><Development><Diagnosis><ECG><EKG><Electrocardiogram><Electrocardiography><Encapsulated><Event><Geometry><Goals><Heart Arrest><Heart Arrhythmias><Heart Diseases><Image><Implantable Cardioverter-Defibrillators><Implantable Defibrillators><Industrialized Countries><Industrialized Nations><Lead><Learning><Left Ventricles><Left ventricular structure><MR Imaging><MR Tomography><MRI><MRI Scans><MRIs><Magnetic Resonance Imaging><Magnetic Resonance Imaging Scan><Maps><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Methodology><Methods><Mission><Modality><Modeling><Morphology><Myocardium><NHLBI><NIH><NMR Imaging><NMR Tomography><National Heart, Lung, and Blood Institute><National Institutes of Health><Nature><Nuclear Magnetic Resonance Imaging><Patient Care><Patient Care Delivery><Patients><Pb element><Population><Premature Ventricular Beats><Premature Ventricular Contractions><Probabilistic Models><Probability Models><Procedures><Prospective, cohort study><Public Health><R15 Mechanism><R15 Program><Radiation therapy><Radiotherapeutics><Radiotherapy><Recurrence><Recurrent><Research><Right Ventricles><Right ventricular structure><Role><Site><Software><Statistical Models><Structure><Surface><System><Techniques><Technology><Time><Tissues><Tomodensitometry><United States><United States National Institutes of Health><Ventricular><Ventricular Arrhythmia><Ventricular Ectopic Beats><Ventricular Extrasystole><Ventricular Premature Complexes><Ventricular Premature Complices><Ventricular Tachycardia><Work><X-Ray CAT Scan><X-Ray Computed Tomography><X-Ray Computerized Tomography><Xray CAT scan><Xray Computed Tomography><Xray computerized tomography><Zeugmatography><bio-engineered><bio-engineers><bioengineering><biological engineering><cardiac electrophysiology><cardiac muscle><catscan><clinical database><computed axial tomography><computer tomography><computerized><computerized axial tomography><computerized tomography><develop software><developed country><developed nation><developed nations><developing computer software><developmental><heart disorder><heart muscle><heavy metal Pb><heavy metal lead><high risk><image processing><imaging><improved><innovate><innovation><innovative><mortality><non-contrast CT><noncontrast CT><noncontrast computed tomography><novel><prospective><radiation treatment><signal processing><social role><software development><statistical linear mixed models><statistical linear models><success><three dimensional><time use><treatment with radiation><usability>
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Laura A. Rabin

BROOKLYN COLLEGE, NEW YORK, NY

Exploratory lead · 0/100
$40,472
FY 2023

Project Title

Novel Multimodal Assessment of Practical Judgment Across the Alzheimer's Continuum: Toward a Better Understanding of how to Predict Risk in the Elderly

Grant Number:

3R15AG066039-01S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2020

End Date:

7/31/2024

Project Abstract

ABSTRACT By the year 2050, as many as 16 million individuals in the U.S. will express symptoms of Alzheimer’s disease (AD). A recent White House Conference on Aging emphasized the need to improve detection of diminished capacity as a means to improve personal safety and prevent financial exploitati...

Research Terms

<AD dementia><Address><Age><Aging><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease risk><Alzheimers Dementia><Apo-E><ApoE><ApoE protein><Apolipoprotein E><Behavior><Brain><Brain Nervous System><Broadening Participation><Clinical><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive aging><Cognitive decline><Cognitive function abnormal><DWI (diffusion weighted imaging)><DWI-MRI><Data><Dependence><Detection><Development><Diffusion MRI><Diffusion Magnetic Resonance Imaging><Diffusion Weighted MRI><Diffusion weighted imaging><Diffusion-weighted Magnetic Resonance Imaging><Disturbance in cognition><Early Diagnosis><Early identification><Education><Educational aspects><Elderly><Employment><Encephalon><Functional MRI><Functional Magnetic Resonance Imaging><Genetic><Genetic predisposing factor><Goals><Groups at risk><History><Impaired cognition><Individual><Infrastructure><Institution><Intervention><Intervention Strategies><Judgment><Laboratories><Life><Literature><Measures><Mentors><Methods><Monitor><Neurocognitive><Neuropsychologies><Neuropsychology><Outcome><Patient Care><Patient Care Delivery><People at risk><Persons at risk><Population><Populations at Risk><Position><Positioning Attribute><Predicting Risk><Primary Senile Degenerative Dementia><Public Health><Recording of previous events><Research><Rest><Risk><Safety><Symptoms><Syndrome><Techniques><Underrepresented Groups><Underrepresented Populations><Work><advanced age><ages><alzheimer risk><brain based><broadening participation research><clinical diagnosis><cognitive ability><cognitive assessment><cognitive dysfunction><cognitive loss><cognitive testing><college><collegiate><conference><convention><dMRI><developmental><diffusion tensor imaging><early detection><elders><experience><fMRI><financial exploitation><forecasting risk><functional status><genetic risk factor><geriatric><histories><improved><inherited factor><innovate><innovation><innovative><interventional strategy><late life><later life><mild cognitive disorder><mild cognitive impairment><multi-modality><multimodality><neural><neural imaging><neural network><neuro-imaging><neuroimaging><neurological imaging><neuropsychologic><novel><older adult><older person><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive risk><predicts risk><prevent><preventing><primary degenerative dementia><programs><recruit><risk prediction><risk predictions><senile dementia of the Alzheimer type><senior citizen><summit><symposia><symposium><under representation of groups><under represented groups><under represented people><under represented populations><undergrad><undergraduate><undergraduate student><underrepresentation of groups><underrepresented people>
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Emil Khisamutdinov

BALL STATE UNIVERSITY, MUNCIE, IN

Exploratory lead · 0/100
$39,695
FY 2023

Project Title

Nucleic Acid Nanoparticle-based Monoclonal Antibody Mimics

Grant Number:

3R15EB031388-01S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2021

End Date:

8/31/2024

Project Abstract

ABSTRACT Therapeutic monoclonal antibodies (mAbs) are the fastest growing class of new therapeutic agents. They hold great promise for the treatment of various types of cancer including prostate cancer (PC). However, their complex structure, selection difficulties, high costs of production, cross r...

Research Terms

<19S Gamma Globulin><3-D><3-Dimensional><3D><7S Gamma Globulin><Abscission><Academic Research Enhancement Awards><Affect><Affinity><American Cancer Society><Animals><Antigenic Determinants><Antigens><Avidity><Award><Binding><Binding Determinants><Biologic Sciences><Biological Sciences><Bioscience><Blood Serum><Cancer Cause><Cancer Etiology><Cancer Treatment><Cancers><Cell Body><Cell Survival><Cell Viability><Cells><Cessation of life><Chemicals><Chemistry><Clinical Treatment Moab><Coloring Agents><Complex><DNA><Death><Deoxyribonucleic Acid><Detection><Development><Diagnosis><Diagnostic><Discipline><Disease><Disorder><Drugs><Dyes><Epitopes><Excision><Exhibits><Extirpation><FOLH><FOLH1><FOLH1 gene><Folate Hydrolase 1><GCP2><Glutamate Carboxypeptidase II><Goals><Human><IgA><IgD><IgE><IgG><IgM><Image><Immune><Immunes><Immunochemical Immunologic><Immunoglobulin A><Immunoglobulin D><Immunoglobulin E><Immunoglobulin G><Immunoglobulin M><Immunologic><Immunological><Immunologically><Immunologics><In Vitro><Institution><Interdisciplinary Research><Interdisciplinary Study><LNCaP><Laboratory Research><Libraries><Life Sciences><MAb Therapeutics><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Prostate><Malignant neoplasm of prostate><Malignant prostatic tumor><Medication><Modern Man><Modern Medicine><Molecular Interaction><Monoclonal Antibodies><Monoclonal Antibody Therapy><Multidisciplinary Collaboration><Multidisciplinary Research><N-Acetylated Alpha-Linked Acidic Dipeptidase 1><NAALAD1><NAALADase I><Nanotechnology><Non-Polyadenylated RNA><Nucleic Acids><Oligo><Oligonucleotides><PSM><PSMA><Pharmaceutic Preparations><Pharmaceutical Preparations><Population><Position><Positioning Attribute><Production><Property><Prostate><Prostate CA><Prostate CA therapy><Prostate Cancer><Prostate Cancer therapy><Prostate Gland><Prostate malignancy><Prostate-Specific Membrane Antigen><Prostatic Cancer><Prostatic Gland><R15 Mechanism><R15 Program><RNA><RNA Gene Products><Removal><Reporting><Research><Resistance><Ribonucleic Acid><Screening for Prostate Cancer><Serum><Shapes><Side><Specificity><Structure><Surface Plasmon Resonance><Surgical Removal><System><Therapeutic><Therapeutic Agents><Therapeutic Effect><Therapeutic Monoclonal Antibodies><Therapeutic Uses><Thermodynamic><Thermodynamics><Variant><Variation><Work><anti-cancer therapy><anticancer therapy><antigen binding><antigen bound><aptamer><cancer therapy><cancer type><cancer-directed therapy><career><chemical stability><cost><cross reactivity><design><designing><detect prostate cancer><developmental><dimer><drug/agent><experience><full scale manufacturing><graduate student><imaging><immunogen><immunogenicity><in vivo><in vivo Model><innovate><innovation><innovative><large scale manufacturing><large scale production><mAB-based therapy><mAb therapy><mAb-based therapeutics><mAbs><malignancy><mass production><meeting><meetings><men><monoclonal Abs><monoclonal antibody drugs><monomer><nano><nano particle><nano tech><nano technology><nano-sized particle><nano-technological><nanoparticle><nanosized particle><nanotech><nanotechnological><neoplasm/cancer><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><oligos><prostate cancer cell><prostate cancer detection><prostate cancer early detection><prostate cancer treatment><prostate tumor cell><resection><resistant><scaffold><scaffolding><student engagement><student motivation><student participation><therapeutic mAbs><three dimensional><undergrad><undergraduate><undergraduate student>
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Ke Zhang Reid

WAKE FOREST UNIVERSITY, WINSTON-SALEM, NC

Exploratory lead · 0/100
$39,267
FY 2022

Project Title

Request fund to purchase equipment (the BioComp gradient primer) to supplement R15 GM139107-01

Grant Number:

3R15GM139107-01S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2020

End Date:

8/31/2024

Project Abstract

Project Summary (Abstract): We are applying for a supplement fund to purchase a BioComp gradient primer for fractionating density gradients. This equipment is essential for the success of the parent award as several proposed experiments, including polysome profiling, ribosome profiling, and Translat...

Research Terms

<Address><Affinity Chromatography><Age><Amino Acids><Award><Chemistry><DNA Molecular Biology><Data><Data Analyses><Data Analysis><Device Failures><Disputes><Education and Training><Environment><Equipment><Equipment Malfunction><Evolution><Fission Yeast><Funding><Heterogeneity><Institution><Intelligence><Investigation><Laboratories><Messenger RNA><Modernization><Molecular Biology><Molecular Configuration><Molecular Conformation><Molecular Stereochemistry><Parents><Ph D student><Ph D. student><Ph. D. student><Ph.D student><Ph.D. student><PhD student><PhD. student><Phenotype><Play><Reproducibility of Findings><Reproducibility of Results><Research><Research Training><Ribo-seq><Ribosomal Proteins><Ribosomes><Role><S pombe><S. pombe><Schizosaccharomyces pombe><System><Talents><Training><Training and Education><Transcript><Translating><Translations><Universities><affinity purification><ages><aminoacid><career><college><collegiate><conformation><conformational state><data interpretation><density><doctoral student><equipment acquirement><equipment acquisition><equipment investment><equipment procurement><equipment purchase><equipment purchasing><experiment><experimental research><experimental study><forest><graduate student><insight><instrument acquisition><instrument investment><instrument procurement><instrument purchase><mRNA><mutant><paralog><paralogous gene><polysome profiling><preference><repair><repaired><ribosome footprint profiling><ribosome profiling><social role><success><undergrad><undergraduate><undergraduate student>
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Hans F. Schmitthenner

ROCHESTER INSTITUTE OF TECHNOLOGY, ROCHESTER, NY

Exploratory lead · 0/100
$30,044
FY 2023

Project Title

Molecularly Targeted Probes for Photodynamic Therapy and Imaging of Breast Cancer

Grant Number:

3R15CA260420-01A1S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

5/31/2025

Project Abstract

Summary Page: Administrative Supplement Request to Promote Diversity in Health‐Related Research (R15CA260420) Request: We are seeking an administrative supplement to promote diversity in health‐related research for grant number R15CA260420. This funding would support Mr. Cameron Keene, a 3rd year Bi...

Research Terms

<Administrative Supplement><Affinity><Apoptosis><Apoptosis Pathway><Area><Assay><Binding><Bioassay><Biologic Assays><Biological Assay><Biological Markers><Body Tissues><Breast Cancer><Breast Cancer Cell><Breast Cancer Patient><Breast Cancer Treatment><Breast Cancer cell line><Breast Cancer therapy><Breast Tumor Patient><Breast tumor cell line><Cancer Treatment><Cell Body><Cell Death><Cell Line><CellLine><Cells><Cellular biology><Collaborations><Coloring Agents><Communities><Confocal Microscopy><Dimensions><Disease><Disorder><Dyes><Endocrine Gland Secretion><Epidemic><Fluorescence><Fluorescence Light Microscopy><Fluorescence Microscopy><Funding><Goals><Grant><Health><Hormones><In Vitro><Injections><Keratin><Laboratories><Laser Electromagnetic><Laser Radiation><Lasers><Limited Resection Mastectomy><Local Excision Mastectomy><Lumpectomy><MCF-10A><MCF10A><MCF10A cells><MDA MB 231><MDA-231><MDA-MB231><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Methods><Mice><Mice Mammals><Molecular Interaction><Molecular Target><Monitor><Murine><Mus><NIR dye><NIR imaging><NIR optical imaging><Near-infrared Fluorescence Imaging><Near-infrared optical imaging><Operative Procedures><Operative Surgical Procedures><PUVA><PUVA Photochemotherapy><Patients><Peptide Synthesis><Peptides><Phase><Photochemotherapy><Photodynamic Therapy><Photosensitizers><Photosensitizing Agents><Programmed Cell Death><Qualifying><R-Series Research Projects><R01 Mechanism><R01 Program><Receptor Protein><Reoperation><Repeat Surgery><Reporting><Research><Research Grants><Research Project Grants><Research Projects><Residual><Residual state><Science><Solid><Strains Cell Lines><Students><Surgical><Surgical Interventions><Surgical Procedure><TNBC><Testing><Therapeutic Hormone><Tissues><Tumor Cell><Work><anti-cancer research><anti-cancer therapy><anticancer research><anticancer therapy><bio-markers><biologic marker><biomarker><breast imaging><breast lumpectomy><breast tumor cell><cancer imaging><cancer research><cancer therapy><cancer-directed therapy><cell biology><classroom environment><college atmosphere><collegial atmosphere><collegiate atmosphere><cultured cell line><deaf><deafened><design><designing><education atmosphere><educational atmosphere><educational environment><efficacy testing><experiment><experimental research><experimental study><experiments><fluorescence imaging><fluorescent imaging><hard of hearing><imaging agent><in vivo><in vivo evaluation><in vivo testing><intellectual atmosphere><learning atmosphere><learning environment><malignant breast neoplasm><malignant breast tumor><mammary imaging><member><minimally invasive><near IR dye><near infrared dye><near infrared imaging><necrocytosis><neoplasm/cancer photoradiation therapy><neoplastic cell><next generation><novel><oncologic imaging><oncology imaging><operation><operations><photosensitizer><profound hearing loss><receptor><school atmosphere><school climate><side effect><surgery><targeted agent><training atmosphere><triple-negative breast cancer><triple-negative invasive breast carcinoma><tumor><tumor imaging><undergrad><undergraduate><undergraduate student><university atmosphere>
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SAUL M HONIGBERG

UNIVERSITY OF MISSOURI KANSAS CITY, KANSAS CITY, MO

Exploratory lead · 0/100
$28,000
FY 2022

Project Title

Admin. supplement for equipment to Mechanisms underlying the Rlm1-dependent G1 checkpoint (NIH R15 GM135807)

Grant Number:

3R15GM135807-01S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2020

End Date:

4/30/2024

Project Abstract

(from parent grant) As cells divide the different cellular programs of cell division must be coordinated with one another. For example, the duplication of chromosomes, the separation of these duplicated chromosomes, and the division of one cell into two cells must all occur at precise times relative...

Research Terms

<Assay><Basal Transcription Factor><Basal transcription factor genes><Bioassay><Biologic Assays><Biological Assay><Blastomyces brasiliensis><Bypass><Cancers><Cell Body><Cell Communication and Signaling><Cell Components><Cell Cycle><Cell Cycle Control><Cell Cycle Progression><Cell Cycle Regulation><Cell Cycle Stage><Cell Death><Cell Division Cycle><Cell Growth and Maintenance><Cell Maintenance><Cell Signaling><Cell Structure><Cell Wall><Cell division><Cell surface><Cells><Cellular Structures><Cellular injury><Chromosomes><Cytology><Disease><Disorder><Enzyme Gene><Enzymes><Equipment><Event><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Alteration><Genetic Change><Genetic defect><High-Risk Cancer><Intracellular Communication and Signaling><Lacazia loboi><Lead><Link><Loboa loboi><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Molecular><Morphology><Mutation><NIH><Names><National Institutes of Health><Nature><Paracoccidioides brasiliensis><Pathogenesis><Pathogenicity><Pb element><Position><Positioning Attribute><Proteins><Role><Signal Transduction><Signal Transduction Systems><Signaling><Stress><Structure><Testing><Time><Transcription Factor Proto-Oncogene><Transcription factor genes><United States National Institutes of Health><Work><Yeasts><anti-cancer therapeutic><anticancer therapeutic><biological signal transduction><cancer cell><cell damage><cell injury><cellular damage><damage to cells><daughter cell><genome mutation><heavy metal Pb><heavy metal lead><human pathogen><injury to cells><malignancy><mutant><necrocytosis><neoplasm/cancer><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><parent grant><programs><repair><repaired><response><social role><transcription factor>
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Lan Jiang

OAKLAND UNIVERSITY, ROCHESTER, MI

Exploratory lead · 0/100
$23,487
FY 2023

Project Title

Acquisition of an Olympus SZX7 fluorescent stereo microscope for dissecting late-stage Drosophila embryos and selecting Drosophila embryos with GFP/RFP tagged genes

Grant Number:

3R15GM140376-01A1S2

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2021

End Date:

6/30/2025

Project Abstract

Acquisition of an Olympus SZX7 fluorescent stereo microscope for dissecting late-stage Drosophila embryos and selecting Drosophila embryos with GFP/RFP tagged genes This proposal is for the acquisition of an Olympus SZX7 fluorescent stereo microscope to replace an old and broken fluorescence stere...

Research Terms

<2-oxo-propanal><Acetylformaldehyde><Air><Antibodies><Apical><Assay><Autophagosome><Award><Binding><Binding Proteins><Bioassay><Biologic Assays><Biologic Models><Biological Assay><Biological Models><Blood Vessels><Cell Coat><Cell-Extracellular Matrix><Cessation of life><Chromosomes><Co-Immunoprecipitations><Cytoplasm><Cytoplasmic Vesicles><Death><Defect><Deposit><Deposition><Disease><Disorder><Dissection><Drosophila><Drosophila eye><Drosophila genus><Drug Metabolic Detoxication><Drug Metabolic Detoxification><ECM><Embryo><Embryonic><Endosomes><Epithelial Cells><Epithelium><Extracellular Matrix><Flies><Fluorescence><Gases><Gene Family><Genes><Genetic><Glycocalyx><Glycolysis><Glyoxalase I><Goals><Golgi><Golgi Apparatus><Golgi Complex><Human><Image><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Individual><Insecta><Insects><Insects Invertebrates><Invertebrata><Invertebrates><Kidney><Kidney Urinary System><Knowledge><Lactoyl Glutathione Lyase><Lactoylglutathione Lyase><Life><Ligand Binding Protein><Ligand Binding Protein Gene><Light><Liquid substance><Lung><Lung Respiratory System><Lysosomes><Mediating><Metabolic><Metabolic Drug Detoxications><Metabolism of Toxic Agents><Methylglyoxal><Methylglyoxalase><Microscope><Model System><Modern Man><Molecular Interaction><Morphogenesis><NIH><National Institutes of Health><Organ><Organ System><Organism><Pathway interactions><Phenotype><Photoradiation><Polycystic Kidney><Polycystic Kidney Diseases><Property><Protein Binding><Protein Trafficking><Proteins><Pyruvaldehyde><Pyruvic Aldehyde><R-Series Research Projects><R01 Mechanism><R01 Program><Receptosomes><Recombinants><Research Grants><Research Project Grants><Research Projects><Role><Shapes><Structure><System><Testing><Time><Trachea><Trachea Proper><Tube><Tubular><Tubular formation><UV laboratory microscope><Ultraviolet Microscopes><United States National Institutes of Health><Vertebrae><Vertebral><Vertebrate Animals><Vertebrates><Vesicle><Yeasts><body system><bound protein><detoxification><exosome><experiment><experimental research><experimental study><experiments><fluid><fluorescence microscope><fluorescence/UV microscope><fluorescent microscope><fly><fruit fly><gene function><glyoxalase><imaging><in vivo><laboratory fluorescence light microscope><liquid><living system><malformation><member><monolayer><morphogenetic process><mutant><pathway><protein biomarkers><protein markers><protein transport><pulmonary><renal><repair><repaired><secretion process><social role><spine bone structure><trafficking><vascular><vertebrata><windpipe>
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Lan Jiang

OAKLAND UNIVERSITY, ROCHESTER, MI

Exploratory lead · 0/100
$18,985
FY 2022

Project Title

Acquisition of a Drosophila chamber for culturing Drosophila strains

Grant Number:

3R15GM140376-01A1S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2021

End Date:

6/30/2025

Project Abstract

This proposal is for the acquisition of a Drosophila chamber to replace an old and broken chamber, which was used to culture Drosophila strains in our laboratory. The awarded NIH R15 research project is to study the role of a poorly understood Osiris (Osi) gene family in regulating tube maturation i...

Research Terms

<2-oxo-propanal><Acetylformaldehyde><Air><Apical><Assay><Autophagosome><Award><Binding><Binding Proteins><Bioassay><Biologic Assays><Biologic Models><Biological Assay><Biological Models><Blood Vessels><Cell Coat><Cell-Extracellular Matrix><Cessation of life><Co-Immunoprecipitations><Cytoplasmic Vesicles><Death><Defect><Deposit><Deposition><Disease><Disorder><Drosophila><Drosophila eye><Drosophila genus><Drug Metabolic Detoxication><Drug Metabolic Detoxification><ECM><Endosomes><Epithelial><Epithelial Cells><Extracellular Matrix><Flies><Gases><Gene Family><Genes><Genetic><Genetic Alteration><Genetic Change><Genetic defect><Glycocalyx><Glycolysis><Glyoxalase I><Goals><Golgi><Golgi Apparatus><Golgi Complex><Human><Humidity><Image><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Individual><Insecta><Insects><Insects Invertebrates><Invertebrata><Invertebrates><Kidney><Kidney Urinary System><Knowledge><Laboratories><Lactoyl Glutathione Lyase><Lactoylglutathione Lyase><Lead><Life><Ligand Binding Protein><Ligand Binding Protein Gene><Light><Liquid substance><Lung><Lung Respiratory System><Lysosomes><Mediating><Metabolic><Metabolic Drug Detoxications><Metabolism of Toxic Agents><Methylglyoxal><Methylglyoxalase><Model System><Modeling><Modern Man><Molecular Interaction><Morphogenesis><Mutation><NIH><National Institutes of Health><Organ><Organ System><Organism><Pathway interactions><Pb element><Phenotype><Photoradiation><Play><Polycystic Kidney><Polycystic Kidney Diseases><Property><Protein Binding><Protein Trafficking><Proteins><Pyruvaldehyde><Pyruvic Aldehyde><R-Series Research Projects><R01 Mechanism><R01 Program><Receptosomes><Renal Vascular><Renal vessels><Research><Research Grants><Research Project Grants><Research Projects><Role><Shapes><Structure><System><Temperature><Testing><Time><Trachea><Trachea Proper><Transgenes><Tube><Tubular><Tubular formation><United States National Institutes of Health><Vascular Diseases><Vascular Disorder><Vertebrae><Vertebral><Vertebrate Animals><Vertebrates><Vesicle><Yeasts><blood vessel disorder><body system><bound protein><detoxification><exosome><experiment><experimental research><experimental study><extracellular><fluid><fly><fruit fly><gene function><gene testing><gene-based testing><genetic testing><genome mutation><glyoxalase><heavy metal Pb><heavy metal lead><human disease><imaging><in vivo><instrument><kidney vascular><kidney vascular structure><liquid><living system><malformation><member><monolayer><morphogenetic process><mutant><pathway><protein biomarkers><protein markers><protein transport><pulmonary><renal><renovascular><secretion process><social role><spine bone structure><trafficking><vascular><vascular dysfunction><vasculopathy><vertebrata><windpipe>
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Ryan McGorty

UNIVERSITY OF SAN DIEGO, SAN DIEGO, CA

Exploratory lead · 0/100
$16,925
FY 2022

Project Title

Biomimetic cytoskeleton and advanced microscopy to reveal intracellular DNA dynamics and distributions

Grant Number:

3R15GM123420-02S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2017

End Date:

5/31/2024

Project Abstract

Project Summary/Abstract The proposed diversity supplement is to support undergraduate researcher, Juexin Marfai, a Pacific Islander non-native English speaker, and Navy veteran who transferred to University of San Diego from community college during the pandemic; and, in turn, to enhance the divers...

Research Terms

<2 year college><Biological Mimetics><Biomedical Research><Biomimetics><Biophysics><Cellular Matrix><Circular DNA><Complement><Complement Proteins><Cytoskeletal System><Cytoskeleton><DNA><Deoxyribonucleic Acid><Doctor of Philosophy><Enrollment><Enzyme Gene><Enzymes><Exhibits><Fellowship><Funding><Goals><Grant><Health><In Situ><In Vitro><Interview><Investigators><Measurement><Mentors><Mentorship><Microscopy><Molecular Configuration><Molecular Conformation><Molecular Stereochemistry><NIH><National Institutes of Health><Pacific Islander><Paper><Parents><Ph.D.><PhD><Position><Positioning Attribute><Property><Publishing><Research><Research Personnel><Researchers><Secure><Technical Expertise><Time><Training><United States National Institutes of Health><Universities><Veterans><Work><Writing><biophysical foundation><biophysical principles><biophysical sciences><career fair><career networking><community college><conformation><conformational state><design><designing><enroll><experiment><experimental research><experimental study><falls><intracellular skeleton><junior college><non-Native><nonnative><pandemic><pandemic disease><parent grant><pre-doc><pre-doctoral><predoc><predoctoral><professional networking><programs><skills><speed networking><technical skills><two year college><undergrad><undergraduate><undergraduate research><undergraduate student>
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Rae Marie Robertson-Anderson

UNIVERSITY OF SAN DIEGO, SAN DIEGO, CA

Exploratory lead · 0/100
$16,925
FY 2022

Project Title

Biomimetic cytoskeleton and advanced microscopy to reveal intracellular DNA dynamics and distributions

Grant Number:

3R15GM123420-02S1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2017

End Date:

5/31/2024

Project Abstract

Project Summary/Abstract The proposed diversity supplement is to support undergraduate researcher, Juexin Marfai, a Pacific Islander non-native English speaker, and Navy veteran who transferred to University of San Diego from community college during the pandemic; and, in turn, to enhance the divers...

Research Terms

<2 year college><Biological Mimetics><Biomedical Research><Biomimetics><Biophysics><Cellular Matrix><Circular DNA><Complement><Complement Proteins><Cytoskeletal System><Cytoskeleton><DNA><Deoxyribonucleic Acid><Doctor of Philosophy><Enrollment><Enzyme Gene><Enzymes><Exhibits><Fellowship><Funding><Goals><Grant><Health><In Situ><In Vitro><Interview><Investigators><Measurement><Mentors><Mentorship><Microscopy><Molecular Configuration><Molecular Conformation><Molecular Stereochemistry><NIH><National Institutes of Health><Pacific Islander><Paper><Parents><Ph.D.><PhD><Position><Positioning Attribute><Property><Publishing><Research><Research Personnel><Researchers><Secure><Technical Expertise><Time><Training><United States National Institutes of Health><Universities><Veterans><Work><Writing><biophysical foundation><biophysical principles><biophysical sciences><career fair><career networking><community college><conformation><conformational state><design><designing><enroll><experiment><experimental research><experimental study><falls><intracellular skeleton><junior college><non-Native><nonnative><pandemic><pandemic disease><parent grant><pre-doc><pre-doctoral><predoc><predoctoral><professional networking><programs><skills><speed networking><technical skills><two year college><undergrad><undergraduate><undergraduate research><undergraduate student>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Mi Hye Song

OAKLAND UNIVERSITY, ROCHESTER, MI

Exploratory lead · 0/100
$12,985
FY 2024

Project Title

Administrative Supplements for Equipment Purchase: The Temperature-Controlled Incubator

Grant Number:

3R15GM147857-01S2

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2022

End Date:

8/31/2025

Project Abstract

Project Summary Under the current NIGMS R15 research award (1R15GM147857-01), this proposal requests supplemental equipment funds that will be used to replace an 11-year-old broken incubator for the cultivation of our genetic model system (C. elegans). The parent project focuses on the Proteolytic R...

Research Terms

<11 year old><11 years of age><26 S proteasome complex><26S ATP-Dependent Protease><26S ATP-Dependent Proteasome><26S Proteasome Complex><26S Proteosome><26S protease><26S proteasome><Administrative Supplement><Affect><Autoregulation><Award><Biochemical><Biologic Models><Biological><Biological Models><Biology><Brain><Brain Nervous System><C elegans><C. elegans><C.elegans><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Caenorhabditis elegans><Cancers><Cas nuclease technology><Cell Cycle><Cell Division Cycle><Cell division><Centrioles><Centrosome><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Compensation><Defect><Development><Disease><Disorder><E3 Ligase><E3 Ubiquitin Ligase><Embryo><Embryonic><Encephalon><Ensure><Equipment><Exhibits><Funding><Genetic><Genetic Alteration><Genetic Change><Genetic Models><Genetic analyses><Genetic defect><Genome Instability><Genomic Instability><Goals><Healthcare><Homeostasis><Human><Incubators><Knowledge><MTOC><Malignant Neoplasms><Malignant Tumor><Mediating><Mice><Mice Mammals><Microcephaly><Microtubule-Organizing Center><Model System><Modeling><Modern Man><Molecular Analysis><Monitor><Murine><Mus><Mutation><NIGMS><National Institute of General Medical Sciences><Oncogenesis><Parents><Physiological Homeostasis><Predisposition><Protein Cleavage><Proteins><Proteolysis><Proteolytic Regulation><Quantitative Microscopy><Regulation of Proteolysis><Request for Proposals><Research><Role><Susceptibility><System><Temperature><Testing><Therapeutic Intervention><Transmission><Ubiquitin Ligase Component Gene><Ubiquitin Ligase Gene><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Work><age 11 years><anaphase-promoting complex><biologic><ciliopathy><cyclosome><daughter cell><developmental><eleven year old><eleven years of age><equipment acquirement><equipment acquisition><equipment investment><equipment procurement><equipment purchase><equipment purchasing><genetic analysis><genome editing><genome integrity><genome mutation><genomic editing><genomic integrity><health care><human disease><imaging system><in vivo><in vivo Model><instrument acquisition><instrument investment><instrument procurement><instrument purchase><intervention therapy><malignancy><micrencephaly><microencephaly><mutant><nano><neoplasm/cancer><parent><parent award><parent project><recruit><social role><success><transmission process><tumorigenesis><ubiquitin ligase><ubiquitin-protein ligase>
View Full Project Details on NIH Reporter
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How to Use PI Funding Data for Career Decisions

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Data limits

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For details on source coverage and refresh cadence, read Data & Methodology.

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Principal investigators who received NIH awards in the last 90 days, organized by research area. Use this as a starting point for postdoc searches, collaborator outreach, or competitor scans. Counts and labs refresh daily.

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GLP-1 & metabolic disease

Diabetes, obesity, and weight-loss therapeutic mechanisms.

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    $231,000 · awarded Apr 17, 2026 · 1R56DK141545-01A1
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