NIH RFA · NIAID · U54
RFA-AI-28-031: Centers for Structural Biology of HIV and Other Infectious Diseases (U54 Clinical Trial Not Allowed)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The purpose of this notice of funding opportunity (NOFO) is to support multidisciplinary consortia of structural biologists, microbiologists, and associated experts to solve complex biological structures related to the prevention, treatment, and cure of HIV and other infectious diseases. Centers are expected to facilitate new collaborations, leverage shared resources, offer services and resources to the research community, and train the next generation of scientists engaged in structural biology of infectious diseases.
- NOFO number
- RFA-AI-28-031
- Type
- RFA
- Activity code
- U54
- Primary institute
- NIAID · National Institute of Allergy and Infectious Diseases
- Clinical trials
- Not Allowed
- Posted
- Oct 2, 2026
- Opens
- Apr 28, 2027
- Expires
- May 29, 2027
RFA-AI-28-031 due dates
1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| May 28, 2027 | Not Applicable | Not Applicable | November 2027 | January 2028 | April 2028 |
Funded projects
NIH RePORTER lists no awards under RFA-AI-28-031 in FY2022–FY2026, and it is a new NOFO rather than a reissue. Awards usually appear a few months after the first review cycle.
Participating institutes
2 NIH institutes and offices take applications under RFA-AI-28-031. Contact the program officer at the institute that fits your research before applying.
- NIAID · National Institute of Allergy and Infectious Diseases
- OAR
Related notices
Jan 23, 2026 · NOT-OD-26-031
NIH Pause on New Submissions to the NIH Human Embryonic Stem Cell Registry and Request for Information on Reducing Reliance on Human Embryonic Stem Cells in NIH-Supported Research.
Award terms
- Application types allowed
- New The OER Glossary and the How to Apply - Application Guide provides details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets are not expected to exceed 3.5 million in direct costs and need to reflect the actual needs of the proposed project.
- Project period
- The total project period must be five years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- NIAID intends to commit 33 million in FY 2028 to fund up to 6 HIV and up to 2 Infectious Diseases awards.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Other open NOFOs for U54
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.