NIH RFA · NIAID · U54
RFA-AI-28-012: Translational Centers Using Microphysiological Systems for Infectious Diseases (U54 Clinical Trial Not Allowed)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 26, 2026Editorial standards
The purpose of this notice of funding opportunity (NOFO) is to support a consortium of Translational Centers using Microphysiological Systems (MPS) for Infectious Diseases (TCMID). Recent efforts in the MPS fields are moving towards validation and regulatory use but have not focused upon models studying infectious diseases and testing of medical interventions. The NIH and FDA have recently issued guidance and established initiatives for enhancing use of New Approach Methodologies (NAMs) in research and product development. This includes in vitro systems that allow scientists to model human disease and capture human variability and patient-specific characteristics that will accelerate safer…
- NOFO number
- RFA-AI-28-012
- Type
- RFA
- Activity code
- U54
- Primary institute
- NIAID · National Institute of Allergy and Infectious Diseases
- Clinical trials
- Not Allowed
- Posted
- Oct 20, 2026
- Opens
- Dec 29, 2026
- Expires
- Jan 30, 2027
RFA-AI-28-012 due dates
1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| January 29, 2027 | Not Applicable | Not Applicable | July 2027 | October 2027 | January 2028 |
Funded projects
NIH RePORTER lists no awards under RFA-AI-28-012 in FY2022–FY2026, and it is a new NOFO rather than a reissue. Awards usually appear a few months after the first review cycle.
Participating institutes
3 NIH institutes and offices take applications under RFA-AI-28-012. Contact the program officer at the institute that fits your research before applying.
- NIAID · National Institute of Allergy and Infectious Diseases
- OAR
- OD · NIH Office of the Director
Related notices
Jan 23, 2026 · NOT-OD-26-031
NIH Pause on New Submissions to the NIH Human Embryonic Stem Cell Registry and Request for Information on Reducing Reliance on Human Embryonic Stem Cells in NIH-Supported Research.
Award terms
- Application types allowed
- New The OER Glossary and the How to Apply - Application Guide provides details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets are not limited but need to reflect the actual needs of the proposed project.
- Project period
- The scope of the proposed project should determine the project period. The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The following NIH components intend to commit the following amounts in FY 2028: NIAID, 9M, 5-7 awardsNIH OD Office of Research Innovation, Validation, and Application ORIVA), 4M, 1-2 awardsNIH Office of AIDS Research OAR), 2M, 1-2 awards
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Other open NOFOs for U54
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. NIH Guide data refreshed October 26, 2026, RePORTER funding October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.