NIH PAR · NHGRI · R21
PAR-25-369: Ethical, Legal and Social Implications (ELSI) Exploratory/Developmental Research Grant (R21 Clinical Trial Optional)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The purpose of this NOFO is to invite Exploratory/Developmental Research Grant (R21) applications that propose to study the ethical, legal, and social implications (ELSI) of human genetics and genomics. Applications may propose studies using either single or mixed methods. Approaches may include but are not limited to empirical qualitative and quantitative methods, as well as conceptual, legal, and normative analyses. Direct involvement of key stakeholders where appropriate is encouraged. Of particular interest are studies that explore the implications of new or emerging genomic technologies or novel uses of genomic information.
- NOFO number
- PAR-25-369
- Type
- PAR
- Activity code
- R21
- Primary institute
- NHGRI · National Human Genome Research Institute
- Clinical trials
- Optional
- Posted
- Jan 13, 2025
- Opens
- Jan 20, 2025
- Expires
- Nov 19, 2026
PAR-25-369 due dates
1 application due date remains before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Application Due Date(s) | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| February 20, 2025 | March 19, 2025 | Not Applicable | July 2025 | October 2025 | December 2025 |
| June 17, 2025 | July 18, 2025 | Not Applicable | November 2025 | January 2026 | April 2026 |
| October 20, 2025 | November 18, 2025 | Not Applicable | March 2026 | May 2026 | July 2026 |
| February 19, 2026 | March 18, 2026 | Not Applicable | July 2026 | October 2026 | December 2026 |
| June 18, 2026 | July 20, 2026 | Not Applicable | November 2026 | January 2027 | April 2027 |
| October 20, 2026 | November 18, 2026 | Not Applicable | March 2027 | May 2027 | July 2027 |
Projects funded under PAR-25-369
NIH RePORTER lists 1 project funded under PAR-25-369 in FY2022–FY2026, with $440K in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.
Projects funded
1
Distinct projects, FY2022–FY2026
New awards
1
Type 1 (new project) award records
NIH funding
$440K
Award dollars under PAR-25-369, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 0 | 0 | $0 |
| FY2026 | 1 | 1 | $440K |
Institutions with the most funding
- Baylor College of Medicine$440K · 1 project
Funding institutes
- NHGRI$440K · 1
Activity codes funded
- R211 record
Most recent new awards
- Identifying Unmet Needs to Support Individuals Impacted by Misattributed Parentage Events (The SupportSeq Study) (opens NIH RePORTER)
Baylor College of Medicine · 1R21HG014919-01 · NHGRI · Notice Sep 4, 2026
$440KR21
What its predecessor PAR-23-294 funded
PAR-25-369 reissues PAR-23-294. Its funding history is the best guide to who wins under this program: 1 project and $428K in FY2022–FY2026.
Projects funded
1
Distinct projects, FY2022–FY2026
New awards
1
Type 1 (new project) award records
NIH funding
$428K
Award dollars under PAR-23-294, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 1 | 1 | $428K |
| FY2026 | 0 | 0 | $0 |
Institutions with the most funding
- Univ of North Carolina Chapel Hill$428K · 1 project
Funding institutes
- NIAID$428K · 1
Activity codes funded
- R211 record
Most recent new awards
- Ethical, Legal, and Social Implications of the Human Virome (opens NIH RePORTER)
Univ of North Carolina Chapel Hill · 1R21AI188572-01 · NIAID · Notice Jul 23, 2025
$428KR21
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
15 NIH institutes and offices take applications under PAR-25-369. Contact the program officer at the institute that fits your research before applying.
- NHGRI · National Human Genome Research Institute
- NEI · National Eye Institute
- NIAID · National Institute of Allergy and Infectious Diseases
- NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NIDCD · National Institute on Deafness and Other Communication Disorders
- NIDCR · National Institute of Dental and Craniofacial Research
- NIDA · National Institute on Drug Abuse
- NIEHS · National Institute of Environmental Health Sciences
- NIMH · National Institute of Mental Health
- NINDS · National Institute of Neurological Disorders and Stroke
- FIC · Fogarty International Center
- NCI · National Cancer Institute
- THRO
- OBSSR
- ORWH
Related notices
Nov 13, 2023 · NOT-HG-24-010
Notice of Pre-Application Webinar for Ethical, Legal and Social Implications ELSI) Research: PAR-23-293 R01 Clinical Trial Optional), PAR-23-294 R21 Clinical Trial Optional) and PAR-23-295 R03 Clinical Trial Optional).
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Award terms
- Application types allowed
- NewResubmission The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets are limited to a combined total of no more than 275,000 in direct costs for the two or three-year project period with no more than 200,000 in direct costs in a single year. Budgets should include costs required to implement the proposed Data Management and Sharing Plan and the proposed Resource Sharing Plan.
- Project period
- The scope of the proposed project should determine the project period. The maximum project period is 3 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAR-23-294.
- Companion NOFOs: PAR-25-370, PAR-25-371.
Other open NOFOs for R21
- PAR-25-256Developing novel theory and methods for understanding the genetic architecture of complex human traits (R21 Clinical Trial Not Allowed)NHGRI · next due Oct 16, 2026
- PA-25-304NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Not Allowed)NIH · next due Oct 16, 2026
- PA-25-306NIH Exploratory/Developmental Research Project Grant (Parent R21 Clinical Trial Required)NIH · next due Oct 16, 2026
- PAR-25-143Dissemination and Implementation Research in Health (R21 Clinical Trial Optional)NCI · next due Oct 16, 2026
- PAR-25-096Secondary Analysis and Integration of Existing Data to Elucidate Cancer Risk and Related Outcomes (R21 Clinical Trials Not Allowed)NCI
- PAR-25-068Pilot Studies of Biological, Behavioral and Social Mechanisms Contributing to HIV Pathogenesis Within the Mission of NIDDK (R21 Clinical Trial Not Allowed)NIDDK · next due Oct 16, 2026
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.