NIH PA · OD · P01
PA-27-061: NIH Research Program Projects (Parent P01 Clinical Trial Optional)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
Through this Notice of Funding Opportunity (NOFO), the participating NIH Institutes, Centers, and Offices (ICOs) invite applications for the investigator-initiated Program Project (P01). A P01 supports a broadly based, multidisciplinary research program with a specific major scientific objective or theme. The proposed Program Projects are focused on the programmatic interests of one or more of the participating ICOs based on their scientific missions. A program project utilizes research projects with a common central scientific theme, an administrative core, and optional shared resource core(s) to accomplish ICOs' programmatic objectives.
- NOFO number
- PA-27-061
- Type
- PA
- Activity code
- P01
- Primary institute
- OD · NIH Office of the Director
- Clinical trials
- Optional
- Posted
- Oct 14, 2026
- Opens
- Oct 20, 2026
- Expires
- May 26, 2029
PA-27-061 due dates
9 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| November 20, 2026 | November 20, 2026 | Not Applicable | March 2027 | May 2027 | July 2027 |
| January 25, 2027 * | January 25, 2027 * | Not Applicable | July 2027 | October 2027 | December 2027 |
| May 25, 2027 * | May 25, 2027 * | Not Applicable | November 2027 | January 2028 | April 2028 |
| September 25, 2027 * | September 25, 2027 * | Not Applicable | March 2028 | May 2028 | July 2028 |
| January 25, 2028 * | January 25, 2028 * | Not Applicable | July 2028 | October 2028 | December 2028 |
| May 25, 2028 * | May 25, 2028 * | Not Applicable | November 2028 | January 2029 | April 2029 |
| September 25, 2028 * | September 25, 2028 * | Not Applicable | March 2029 | May 2029 | July 2029 |
| January 25, 2029 * | January 25, 2029 * | Not Applicable | July 2029 | October 2029 | December 2029 |
| May 25, 2029 * | May 25, 2029 * | Not Applicable | November 2029 | January 2030 | April 2030 |
Funded projects
NIH RePORTER lists no awards under PA-27-061 in FY2022–FY2026, and it is a new NOFO rather than a reissue. Awards usually appear a few months after the first review cycle.
Participating institutes
12 NIH institutes and offices take applications under PA-27-061. Contact the program officer at the institute that fits your research before applying.
- OD · NIH Office of the Director
- NHLBI · National Heart, Lung, and Blood Institute
- NHGRI · National Human Genome Research Institute
- NIA · National Institute on Aging
- NIAAA · National Institute on Alcohol Abuse and Alcoholism
- NIAID · National Institute of Allergy and Infectious Diseases
- NIDA · National Institute on Drug Abuse
- NIEHS · National Institute of Environmental Health Sciences
- NIMHD · National Institute on Minority Health and Health Disparities
- NLM · National Library of Medicine
- NCI · National Cancer Institute
- ORWH
Related notices
Jan 23, 2026 · NOT-OD-26-031
NIH Pause on New Submissions to the NIH Human Embryonic Stem Cell Registry and Request for Information on Reducing Reliance on Human Embryonic Stem Cells in NIH-Supported Research.
Award terms
- Application types allowed
- New Renewal Resubmission Revision The OER Glossary and the How to Apply - Application Guide provides details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets are not limited but need to reflect the actual needs of the proposed project. Applicants are strongly encouraged to contact program officials prior to submitting any application and early in the application planning process. Refer to Large Complex Projects Funding Considerations and Contacts for ICO-specific funding information.
- Project period
- The scope of the proposed project should determine the project period. The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Other open NOFOs for P01
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.