NIH PAR · NIMH · P50
PAR-27-127: Silvio O. Conte Centers for Basic Neuroscience or Translational Mental Health Research (P50 Clinical Trial Optional)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
This notice of funding opportunity (NOFO) encourages applications for Silvio O. Conte Centers for Basic Neuroscience or Translational Mental Health Research. The National Institute of Mental Health (NIMH) seeks teams of integrative researchers working at different levels of analysis and employing novel, and creative experimental approaches to address high-risk, high-impact questions with the primary objectives of: (a) advancing basic brain and behavior research that will uncover underlying mechanisms that could provide the foundation for understanding mental disorders; (b) supporting the integration and translation of basic and clinical neuroscience research on severe mental illnesses; (c)…
- NOFO number
- PAR-27-127
- Type
- PAR
- Activity code
- P50
- Primary institute
- NIMH · National Institute of Mental Health
- Clinical trials
- Optional
- Posted
- Sep 1, 2026
- Opens
- Sep 15, 2026
- Expires
- May 26, 2028
PAR-27-127 due dates
2 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| October 15, 2026 | October 15, 2026 | Not Applicable | March 2027 | May 2027 | July 2027 |
| May 25, 2027 * | May 25, 2027 * | Not Applicable | November 2027 | January 2028 | April 2028 |
| May 25, 2028 * | May 25, 2028 * | Not Applicable | November 2028 | January 2029 | April 2029 |
What its predecessor PAR-22-155 funded
PAR-27-127 reissues PAR-22-155. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 6 projects and $41.6M in FY2022–FY2026.
Projects funded
6
Distinct projects, FY2022–FY2026
New awards
5
Type 1 (new project) award records
NIH funding
$41.6M
Award dollars under PAR-22-155, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 3 | 3 | $9.8M |
| FY2025 | 4 | 0 | $12.7M |
| FY2026 | 6 | 2 | $19.0M |
Institutions with the most funding
- Northwestern University$9.7M · 1 project
- Johns Hopkins University$9.7M · 1 project
- Princeton University$9.6M · 1 project
- University of Minnesota$6.2M · 1 project
- New York State Psychiatric Institute DBA Research Foundation for Mental Hygiene, Inc$3.3M · 1 project
- Duke University$3.1M · 1 project
Funding institutes
- NIMH$41.6M · 13
Activity codes funded
- P5013 records
Most recent new awards
- Duke Conte Center for Basic Neuroscience on Kinase Signaling in Neurodevelopmental Disorders (opens NIH RePORTER)
Duke University · 1P50MH144133-01 · NIMH · Notice Sep 14, 2026
$3.1MP50
- Neural Components of Stress Response and Suicide Behavior: Preventive Impact of Ketamine (opens NIH RePORTER)
New York State Psychiatric Institute DBA Research Foundation for Mental Hygiene, Inc · 1P50MH139573-01A1 · NIMH · Notice Aug 3, 2026
$3.3MP50
- Conte Center: Understanding Latent Cause Inference in Health and Illness (opens NIH RePORTER)
Princeton University · 1P50MH136296-01 · NIMH · Notice Aug 12, 2024
$3.2MP50
- Control of synaptic circuits by small GTPase pathways (opens NIH RePORTER)
Northwestern University · 1P50MH132775-01A1 · NIMH · Notice Apr 19, 2024
$3.3MP50
- Impact of the olfactory system on higher brain function and schizophrenia (opens NIH RePORTER)
Johns Hopkins University · 1P50MH136297-01 · NIMH · Notice Apr 9, 2024
$3.4MP50
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
2 NIH institutes and offices take applications under PAR-27-127. Contact the program officer at the institute that fits your research before applying.
- NIMH · National Institute of Mental Health
- none
Related notices
Jan 23, 2026 · NOT-OD-26-031
NIH Pause on New Submissions to the NIH Human Embryonic Stem Cell Registry and Request for Information on Reducing Reliance on Human Embryonic Stem Cells in NIH-Supported Research.
Award terms
- Application types allowed
- New Renewal Resubmission Revision The OER Glossary and the How to Apply - Application Guide provides details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Direct costs are limited to 2 million in any one year.
- Project period
- The scope of the proposed project should determine the project period. The maximum project period is 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAR-22-155.
Other open NOFOs for P50
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.