NIH PAR · NIGMS · R16

PAR-25-415: Support for Research Excellence First Independent Research (SuRE-First) Award (R16 - Clinical Trial Not Allowed)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: May 28, 2027Expires Sep 8, 2028

The SuRE program supports research capacity building at eligible higher education institutions through funding investigator-initiated biomedical research inbasic, social, clinical, behavioral, or translational science that falls in the mission areas of the NIH. The purpose of SuRE-First awards is to provide support for investigator-initiated research at resource-limited institutions by full-time faculty who have not had any prior independent, peer-reviewed, external research grants, to furnish students with high-quality undergraduate and/or graduate research experiences, and to enhance the institutional scientific research culture.

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-415
Type
PAR
Activity code
R16
Primary institute
NIGMS · National Institute of General Medical Sciences
Clinical trials
Not Allowed
Posted
Jun 13, 2025
Opens
Aug 29, 2025
Expires
Sep 8, 2028

PAR-25-415 due dates

3 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-415
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
September 29, 2025September 29, 2025January 07, 2026 *March 2026May 2026July 2026
May 27, 2026May 27, 2026Not ApplicableNovember 2026January 2027April 2027
September 28, 2026September 28, 2026Not ApplicableMarch 2027May 2027July 2027
May 28, 2027May 28, 2027Not ApplicableNovember 2027January 2028April 2028
September 28, 2027September 28, 2027Not ApplicableMarch 2028May 2028July 2028
May 29, 2028May 29, 2028Not ApplicableNovember 2028January 2029April 2029

Projects funded under PAR-25-415

NIH RePORTER lists 21 projects funded under PAR-25-415 in FY2022–FY2026, with $4.8M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

21

Distinct projects, FY2022–FY2026

New awards

21

Type 1 (new project) award records

NIH funding

$4.8M

Award dollars under PAR-25-415, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-415
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY20262121$4.8M

Institutions with the most funding

  1. University of Puerto Rico Med Sciences$745K · 1 project
  2. University of Pr Cayey University Coll$621K · 1 project
  3. Howard University$383K · 2 projects
  4. Towson University$211K · 1 project
  5. New York Inst of Technology$205K · 1 project
  6. University of Alaska Fairbanks$194K · 1 project
  7. SUNY College at New Paltz$191K · 1 project
  8. New York City College of Technology$190K · 1 project

Funding institutes

  • NINDS$1.4M · 2
  • NIGMS$1.3M · 7
  • NIAID$759K · 4
  • NIBIB$391K · 2
  • NCI$343K · 2
  • NIDDK$178K · 1
  • NIEHS$177K · 1
  • NIAMS$149K · 1

Activity codes funded

  • R1621 records

Most recent new awards

What its predecessor PAR-24-145 funded

PAR-25-415 reissues PAR-24-145. Its funding history is the best guide to who wins under this program: 17 projects and $6.5M in FY2022–FY2026.

Projects funded

17

Distinct projects, FY2022–FY2026

New awards

17

Type 1 (new project) award records

NIH funding

$6.5M

Award dollars under PAR-24-145, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-24-145
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY20251717$3.6M
FY2026160$2.9M

Institutions with the most funding

  1. Rochester Institute of Technology$1.5M · 4 projects
  2. University of Southern Mississippi$750K · 1 project
  3. San Jose State University$733K · 2 projects
  4. College at Old Westbury$399K · 1 project
  5. University of North Florida$370K · 1 project
  6. California State University Hayward$369K · 1 project
  7. St. John's University$367K · 1 project
  8. Rowan University$365K · 1 project

Funding institutes

  • NIGMS$5.0M · 28
  • NIAID$1.1M · 3
  • NIDDK$367K · 2

Activity codes funded

  • R1633 records

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

20 NIH institutes and offices take applications under PAR-25-415. Contact the program officer at the institute that fits your research before applying.

  • NIGMS · National Institute of General Medical Sciences
  • NEI · National Eye Institute
  • NHGRI · National Human Genome Research Institute
  • NIA · National Institute on Aging
  • NIAAA · National Institute on Alcohol Abuse and Alcoholism
  • NIAID · National Institute of Allergy and Infectious Diseases
  • NIAMS · National Institute of Arthritis and Musculoskeletal and Skin Diseases
  • NIBIB · National Institute of Biomedical Imaging and Bioengineering
  • NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
  • NIDCD · National Institute on Deafness and Other Communication Disorders
  • NIDCR · National Institute of Dental and Craniofacial Research
  • NIDDK · National Institute of Diabetes and Digestive and Kidney Diseases
  • NIDA · National Institute on Drug Abuse
  • NIEHS · National Institute of Environmental Health Sciences
  • NIMH · National Institute of Mental Health
  • NINDS · National Institute of Neurological Disorders and Stroke
  • NINR · National Institute of Nursing Research
  • NIMHD · National Institute on Minority Health and Health Disparities
  • NLM · National Library of Medicine
  • NCI · National Cancer Institute

Related notices

  1. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  2. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Notices of Special Interest (NOSIs)

NIH has attached 1 NOSI to PAR-25-415; none are active now. A NOSI flags a topic an institute wants to fund through this NOFO.

Award terms

Application types allowed
NewResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Applications may request up to 125,000 in direct costs per year, excluding consortium facilities and administrative F&A) costs. 
Project period
The scope of the proposed project should determine the project period. The maximum period of support is 4 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the number of meritorious applications received.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PAR-24-145.
  • Companion NOFOs: PAR-25-414.

Other open NOFOs for R16

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

NIH grant searchLook up awards by topic, PI, or institution.Find funded PIsInvestigators with recent NIH awards in your research area.Institute fit by topicWhich NIH institutes and institutions lead a research area.Funding trendsYear-by-year NIH award totals for any keyword.