NIH PAR · NICHD · R01
PAR-25-362: Early Immune System Development and Ontogeny (R01 Clinical Trial Optional)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The purpose of this Notice of Funding Opportunity (NOFO) is tofurther elucidate the mechanisms of early immune development in utero, during the early post-natal period and during early childhood in neonates, infants, and children and adolescents with or without in-utero exposure to HIV or Anti-Retroviral Therapeutics (ART).This initiative aims to understand intricate mechanisms of immune cells at the maternal-fetal interface, T and B cell development and maturation in offspring, and local immune responses and the role of systemic immunity.
- NOFO number
- PAR-25-362
- Type
- PAR
- Activity code
- R01
- Primary institute
- NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
- Clinical trials
- Optional
- Posted
- Dec 30, 2024
- Opens
- Apr 7, 2025
- Expires
- Nov 6, 2028
PAR-25-362 due dates
5 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| Not Applicable | Not Applicable | May 07, 2025 * | July 2025 | October 2025 | December 2025 |
| Not Applicable | Not Applicable | January 07, 2026 * | March 2026 | May 2026 | July 2026 |
| Not Applicable | Not Applicable | May 07, 2026 * | July 2026 | October 2026 | December 2026 |
| October 05, 2026 * | November 05, 2026 | Not Applicable | March 2027 | May 2027 | July 2027 |
| February 05, 2027 | March 05, 2027 * | Not Applicable | July 2027 | October 2027 | December 2027 |
| October 05, 2027 * | November 05, 2027 | Not Applicable | March 2028 | May 2028 | July 2028 |
| February 05, 2028 | March 05, 2028 * | Not Applicable | July 2028 | October 2028 | December 2028 |
| June 05, 2028 * | July 05, 2028 * | Not Applicable | November 2028 | January 2029 | April 2029 |
| October 05, 2028 * | November 05, 2028 | Not Applicable | March 2029 | May 2029 | July 2029 |
Projects funded under PAR-25-362
NIH RePORTER lists 2 projects funded under PAR-25-362 in FY2022–FY2026, with $5.3M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.
Projects funded
2
Distinct projects, FY2022–FY2026
New awards
2
Type 1 (new project) award records
NIH funding
$5.3M
Award dollars under PAR-25-362, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 0 | 0 | $0 |
| FY2026 | 2 | 2 | $5.3M |
Institutions with the most funding
- Oregon Health & Science University$2.7M · 1 project
- Yale University$2.5M · 1 project
Funding institutes
- NICHD$5.3M · 2
Activity codes funded
- R012 records
Most recent new awards
- PRIME: Placental Immune Response and Impact on Maternal-Infant Health (opens NIH RePORTER)
Yale University · 1R01HD121468-01 · NICHD · Notice Jun 26, 2026
$2.5MR01
- Effects of Long-Acting Antiretroviral Therapy on Offspring Immunity in Rhesus Macaques (opens NIH RePORTER)
Oregon Health & Science University · 1R01HD121457-01 · NICHD · Notice May 22, 2026
$2.7MR01
What its predecessor PAR-20-298 funded
PAR-25-362 reissues PAR-20-298. Its funding history is the best guide to who wins under this program: 14 projects and $17.0M in FY2022–FY2026.
Projects funded
14
Distinct projects, FY2022–FY2026
New awards
12
Type 1 (new project) award records
NIH funding
$17.0M
Award dollars under PAR-20-298, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 7 | 5 | $3.2M |
| FY2023 | 11 | 4 | $4.4M |
| FY2024 | 12 | 3 | $5.1M |
| FY2025 | 7 | 0 | $3.2M |
| FY2026 | 3 | 0 | $1.1M |
Institutions with the most funding
- Seattle Children's Hospital$1.8M · 1 project
- University of California, San Diego$1.7M · 1 project
- Oregon Health & Science University$1.6M · 1 project
- University of Colorado Denver$1.5M · 1 project
- University of Vermont & St Agric College$1.4M · 2 projects
- University of Kentucky$1.4M · 1 project
- Weill Medical Coll of Cornell Univ$1.3M · 1 project
- Tulane University of Louisiana$1.3M · 1 project
Funding institutes
- NICHD$13.8M · 34
- NIAID$3.2M · 6
Activity codes funded
- R0139 records
- R561 record
Most recent new awards
- The impact of antiretroviral therapy on fetal immune system development in SIV-exposed rhesus macaques (opens NIH RePORTER)
Oregon Health & Science University · 1R01HD114264-01A1 · NICHD · Notice Sep 20, 2024
$535KR01
- Does the maternal environment during viral infection and inflammation direct fetal T cell development and function? (opens NIH RePORTER)
University of Vermont & St Agric College · 1R01HD111148-01A1 · NICHD · Notice Sep 5, 2024
$395KR01
- Determining themechanism of maternal IL-10 restriction of fetal emergency myelopoiesis to improve neonataloutcomes (opens NIH RePORTER)
Cincinnati Childrens Hosp Med Ctr · 1R01HD116402-01 · NICHD · Notice Aug 16, 2024
$414KR01
- Mechanisms Regulating Inflammatory Phenotypes in Fetal Macrophages (opens NIH RePORTER)
Stanford University · 1R01HD113215-01 · NICHD · Notice Sep 15, 2023
$402KR01
- Microbial-induced maternal factors that influence fetal immune development (opens NIH RePORTER)
University of Minnesota · 1R01HD113192-01 · NICHD · Notice Sep 14, 2023
$300KR01
- Does the Maternal Environment During Viral Infection and Inflammation Direct Fetal Gamma Delta T Cell Development and Function? (opens NIH RePORTER)
University of Vermont & St Agric College · 1R56HD111148-01 · NICHD · Notice Aug 14, 2023
$230KR56
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
2 NIH institutes and offices take applications under PAR-25-362. Contact the program officer at the institute that fits your research before applying.
- NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
- none
Related notices
Jan 28, 2026 · NOT-OD-26-029
NIH Removing AIDS Application Due Dates from NOFOs.
Mar 31, 2025 · NOT-OD-24-084
This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Award terms
- Application types allowed
- NewResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets are limited to 400,000/year Directs Costs exclusive of consortium F&A costs.
- Project period
- A maximum project period of four years is allowed. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAR-20-298.
Other open NOFOs for R01
- PAR-25-265Innovative Screening Approaches and Therapies for Screenable Disorders in Newborns (R01 - Clinical Trial Optional)NICHD · next due Feb 5, 2027
- PAR-25-112Advancement and Innovation in Measurement of Language Development and Predictors (R01 Clinical Trial Not Allowed)NICHD · next due Feb 5, 2027
- PAR-25-227Natural History of Disorders Screenable in the Newborn Period (R01 Clinical Trial Optional)NICHD · next due Feb 5, 2027
- PAR-25-185Screening and Functional Validation of Genomic Variants Associated with Human Congenital Anomalies (R01 Clinical Trial Not Allowed)NICHD · next due Feb 5, 2027
- PAR-25-371Ethical, Legal and Social Implications (ELSI) Research (R01 Clinical Trial Optional)NHGRI · next due Oct 20, 2026
- PAR-25-379Intervention Research to Improve Native American Health (R01 Clinical Trial Optional)NIDA · next due Oct 21, 2026
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.