NIH PAR · NIMH · R01

PAR-25-178: Pilot Hybrid Effectiveness-Implementation Trials for Mental Health Interventions (R01 Clinical Trial Required)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Feb 17, 2027Expires Oct 16, 2027

Pilot Effectiveness Trials for Treatment, Preventive and Services Interventions (R01 Clinical Trial Required). As part of NIMH's clinical trials pipeline NOFOs, this announcement encourages pilot effectiveness studies focused on 1) optimizing the effectiveness of preventive and therapeutic interventions with previously demonstrated efficacy, for use with broader target populations or for use in community practice settings, and 2) developing and preliminary testing innovative services interventions. Consistent with the NIMH experimental therapeutics approach, this NOFO is intended to support pilot studies of intervention effectiveness or service delivery approaches that explicitly address…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-178
Type
PAR
Activity code
R01
Primary institute
NIMH · National Institute of Mental Health
Clinical trials
Required
Posted
Nov 26, 2024
Opens
Jan 14, 2025
Expires
Oct 16, 2027

PAR-25-178 due dates

3 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-178
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
February 14, 2025Not ApplicableNot ApplicableJuly 2025October 2025December 2025
June 17, 2025June 17, 2025Not ApplicableNovember 2025January 2026April 2026
October 15, 2025October 15, 2025Not ApplicableMarch 2026May 2026July 2026
February 13, 2026February 13, 2026Not ApplicableJuly 2026October 2026December 2026
June 15, 2026June 15, 2026Not ApplicableNovember 2026January 2027April 2027
October 15, 2026October 15, 2026Not ApplicableMarch 2027May 2027July 2027
February 17, 2027February 17, 2027Not ApplicableJuly 2027October 2027December 2027
June 15, 2027June 15, 2027Not ApplicableNovember 2027January 2028April 2028
October 15, 2027October 15, 2027Not ApplicableMarch 2028May 2028July 2028

Projects funded under PAR-25-178

NIH RePORTER lists 10 projects funded under PAR-25-178 in FY2022–FY2026, with $4.9M in award dollars. Counts include each project's later non-competing years, which keep the original NOFO number.

Projects funded

10

Distinct projects, FY2022–FY2026

New awards

10

Type 1 (new project) award records

NIH funding

$4.9M

Award dollars under PAR-25-178, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-25-178
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202500$0
FY20261010$4.9M

Institutions with the most funding

  1. Yale University$1.3M · 1 project
  2. Children's Research Institute$479K · 1 project
  3. New York State Psychiatric Institute DBA Research Foundation for Mental Hygiene, Inc$414K · 1 project
  4. McLean Hospital$410K · 1 project
  5. University of California, San Francisco$410K · 1 project
  6. Baylor College of Medicine$406K · 1 project
  7. University of California, San Diego$397K · 1 project
  8. San Diego State University$395K · 1 project

Funding institutes

  • NIMH$4.9M · 10

Activity codes funded

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under PAR-25-178. Contact the program officer at the institute that fits your research before applying.

  • NIMH · National Institute of Mental Health
  • none

Related notices

  1. Mar 31, 2025

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.

  2. Dec 2, 2024 · NOT-MH-25-105

    Notice of the Effectiveness and Services Trials Pre-Application Webinar for PAR-25-177, PAR-25-187, and PAR-25-285. See Notice NOT-MH-25-105.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25, 2025.

  3. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  4. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.

Award terms

Application types allowed
NewResubmissionRevision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Direct costs are limited to 750,000 over the R01 project period, with no more than 250,000 in direct costs allowed in any single year.
Project period
The total project period for an application submitted in response to this funding opportunity may not exceed three years.       NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
NIMH intends to commit a total of 27,000,000 for FY 2026 to fund this NOFO and the companion NOFOs listed in Part 1. Overview Information. nbsp;Future year amounts will depend on annual appropriations.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

Other open NOFOs for R01

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

NIH grant searchLook up awards by topic, PI, or institution.Find funded PIsInvestigators with recent NIH awards in your research area.Institute fit by topicWhich NIH institutes and institutions lead a research area.Funding trendsYear-by-year NIH award totals for any keyword.