NIH PAR · NCI · R01

PAR-25-069: Mechanisms that Impact Cancer Risk with Use of Incretin Mimetics (R01 Clinical Trial Optional)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsExpires Jan 8, 2027

The goal of the proposed funding announcement is twofold, to promote preclinical and patient based studies examining the mechanism(s) through which incretin mimetics (including agonists or antagonists of GLP-1, GIP-1, or dual GLP-1/GIP-1 agents) impact cancer risk, and to draw talented scientists who understand the dynamic changes caused by these agents to investigate the mechanisms of how these agents influence cancer risk rather than shorter term outcomes such as weight loss and diabetes. The data thus far suggests that these agents may increase the risk of some, while decreasing the risk of other obesity related cancers.

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
PAR-25-069
Type
PAR
Activity code
R01
Primary institute
NCI · National Cancer Institute
Clinical trials
Optional
Posted
Nov 18, 2024
Opens
Jan 5, 2025
Expires
Jan 8, 2027

PAR-25-069 due dates

No application due dates remain in the listed cycles. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for PAR-25-069
Application Due Date(s)Renewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
February 05, 2025March 05, 2025 *Not ApplicableJuly 2025October 2025December 2025
June 05, 2025July 05, 2025 *Not ApplicableNovember 2025January 2026April 2026
October 05, 2025November 05, 2025 *Not ApplicableMarch 2026May 2026July 2026
February 05, 2026March 05, 2026 *Not ApplicableJuly 2026October 2026December 2026
June 05, 2026July 05, 2026 *Not ApplicableNovember 2026January 2027April 2027
October 05, 2026November 05, 2026 *Not ApplicableMarch 2027May 2027July 2027

What its predecessor PAR-23-279 funded

PAR-25-069 reissues PAR-23-279. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 3 projects and $2.7M in FY2022–FY2026.

Projects funded

3

Distinct projects, FY2022–FY2026

New awards

3

Type 1 (new project) award records

NIH funding

$2.7M

Award dollars under PAR-23-279, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under PAR-23-279
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202300$0
FY202400$0
FY202511$693K
FY202632$2.0M

Institutions with the most funding

  1. Yale University$1.4M · 1 project
  2. Univ of North Carolina Chapel Hill$1.3M · 2 projects

Funding institutes

  • NCI$2.7M · 4

Activity codes funded

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under PAR-25-069. Contact the program officer at the institute that fits your research before applying.

  • NCI · National Cancer Institute
  • none

Related notices

  1. Mar 31, 2025 · NOT-OD-24-084

    This funding opportunity was updated to align with agency priorities. Carefully reread the full funding opportunity and make any needed adjustments to your application prior to submission.April 4, 2024 - Overview of Grant Application and Review Changes for Due Dates on or after January 25,…

  2. Aug 31, 2022 · NOT-OD-22-198

    Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.

  3. Aug 5, 2022 · NOT-OD-22-189

    Implementation Details for the NIH Data Management and Sharing Policy.

Award terms

Application types allowed
NewResubmission   The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets are not limited but need to reflect the actual needs of the proposed project. 
Project period
The maximum project period is 5 years  NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious awards.  

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of PAR-23-279.
  • Companion NOFOs: PAR-25-070.

Other open NOFOs for R01

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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