NIH DP2 Grants — NIH Director's New Innovator Award

Recent DP2 awards from NIH RePORTER

Examples of funded DP2 projects across the last two fiscal years. The matching-award count comes from the full result set; funding totals, averages, rankings, and examples use the first 500 records returned by NIH RePORTER. Figures reflect a snapshot last refreshed on June 9, 2026.

Example DP2 projects from the sample

• Transcriptional Regulation of the Microbiota-Nutrition Axis in Genetically Diverse Macrophages During Psoriasiform Inflammation.

  1DP2AI192561-01
  Verena Link · UNIVERSITY OF CALIFORNIA AT DAVIS, CA · $483,000 · awarded Jun 3, 2026 · NIH

  Project Summary Psoriasis is a chronic systemic inflammatory disease that affects approximately 100 million people globally. It arises from complex interactions between polygenic host susceptibilities and environmental factors like diet and the microbiome. While many genetic psoriasis susceptibility loci have been identified in Western populations, some of…

• A multipronged, mRNA gene therapy approach to HIV cure

  5DP2AI184637-02
  Edward Kreider · UNIVERSITY OF PENNSYLVANIA, PA · $486,057 · awarded Jun 1, 2026 · NIH

  Abstract CHALLENGE: Pathogen persistence within a host results in lifelong infection and causes significant morbidity and mortality. Viruses that endure, like HIV-1, evade clearance by establishing latent infection and escaping immune responses. Latency is a reversible form of nonproductive infection in which virus transcription is suppressed. As such,…

• Differential regulation of T cell plasma membrane proteins by N-glycan branching and clathrin-mediated endocytosis

  5DP2AI164301-05
  Haik Mkhikian · UNIVERSITY OF CALIFORNIA-IRVINE, CA · $453,009 · awarded May 29, 2026 · NIH

  PROJECT SUMMARY/ABSTRACT Nearly every aspect of T cell biology is determined in part by the relative expression of a multitude of cell-surface proteins. For example, the relative expression of co-stimulatory and co-inhibitory receptors impact pro- versus anti-inflammatory outcomes. N-glycosylation is a critical but poorly understood regulator of cell-…

• Decoding the language of inflammation between central nervous system resident immune cells

  5DP2AI154435-05
  Iain Clark · UNIVERSITY OF CALIFORNIA BERKELEY, CA · $481,500 · awarded May 27, 2026 · NIH

  SUMMARY Interactions between central nervous system (CNS)-resident cells are highly heterogeneous; astrocytes and microglia nourish and protect neurons, while inflammatory subsets drive demyelination and neurodegeneration in neurologic diseases. However, the molecular mechanisms that control CNS-resident immune cell interactions remain mostly unknown…

• Maternal immune activation remodeling of offspring glycosaminoglycan sulfation patterns during neurodevelopment

  7DP2AI171150-04
  Kimberly Alonge · UNIVERSITY OF FLORIDA, FL · $447,543 · awarded May 19, 2026 · NIH

  ABSTRACT Maternal immune activation (MIA) during prenatal or postnatal development significantly increases the risk for offspring neurodevelopmental disorders (NDDs) later in life. Growing evidence suggest that regardless of the MIA stimuli (infectious or environmental), offspring exhibit an enhanced risk for lifelong neuropathology defects ranging from…

• The LINK Intervention: Using informatics and implementation science to reduce missed opportunities to prevent opioid overdose and HIV infection

  1DP2DA066177-01
  Alyssa Tilhou · BOSTON MEDICAL CENTER, MA · $2,670,000 · awarded May 5, 2026 · NIH

  PROJECT SUMMARY / ABSTRACT Opioid use disorder (OUD) is a key driver of opioid overdose (OOD) and HIV incidence. Medications for OUD (MOUD) and pre-exposure prophylaxis for HIV (PrEP) reduce risk of OOD and HIV by 50% and >70%, respectively. Yet treatment initiation rates are low and retention is poor. Optimizing MOUD and PrEP use is crucial to improving…

• Programmable depletion and rescue platform to screen dynamic regulatory events during cellular differentiation.

  3DP2HD118273-01S1
  Sara Zaccara · COLUMBIA UNIVERSITY HEALTH SCIENCES, NY · $85,639 · awarded Apr 28, 2026 · NIH

  PROJECT SUMMARY: The mechanisms by which stem cells orchestrate their program to become functional differentiated cells require accurate temporal regulation of specific gene expression programs. This complex network requires precise temporal regulation of transcription and degradation processes to activate specific programs in a coordinated manner. So far,…

• Move, Eat, Trap, or Kill: Decoding the molecular logic used by innate immune cells to decide between functional programs

  1DP2AI184743-01
  Benjamin Winer · NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NY · $508,500 · awarded Apr 24, 2026 · NIH

  Project Abstract/Summary Candidate: I am a joint postdoctoral scholar in the laboratories of Drs. Morgan Huse (Memorial Sloan Kettering Cancer Center), Jason Cyster (UCSF/HHMI), and Orion Weiner (UCSF). My previous PhD research provided extensive training in infectious diseases, humanized mice and other types of advanced infection mouse models, chemistry,…

• High-throughput discovery of protein energy landscapes in natural and designed proteomes

  3DP2GM140927-01S1
  Gabriel Rocklin · NORTHWESTERN UNIVERSITY, IL · $36,417 · awarded Mar 25, 2026 · NIH

  Project Summary All folded proteins continuously fluctuate between their low-energy native structures and higher-energy “hidden” conformations that can be partially or fully unfolded. Although each protein molecule passes through its high- energy conformations only a small fraction of the time, these states have major physiological consequences.…

• THWART-TB : Testing Health Workers At Risk to advance our understanding of TB infection

  3DP2AI176896-02S1
  Ruvandhi Nathavitharana · BETH ISRAEL DEACONESS MEDICAL CENTER, MA · $111,645 · awarded Feb 26, 2026 · NIH

  PROJECT SUMMARY Tuberculosis (TB) remains a leading infectious cause of death globally. 1.7 billion people worldwide are estimated to have been infected with TB (LTBI); yet TB infection remains poorly understood. Current LTBI tests cannot distinguish between current infection versus a persistent immune response to a cleared infection and have a low…

• THWART-TB : Testing Health Workers At Risk to advance our understanding of TB infection

  4DP2AI176896-02
  Ruvandhi Nathavitharana · BETH ISRAEL DEACONESS MEDICAL CENTER, MA · $338,656 · awarded Feb 23, 2026 · NIH

  PROJECT SUMMARY Tuberculosis (TB) remains a leading infectious cause of death globally. 1.7 billion people worldwide are estimated to have been infected with TB (LTBI); yet TB infection remains poorly understood. Current LTBI tests cannot distinguish between current infection versus a persistent immune response to a cleared infection and have a low…

• Methods to Rapidly Explore Combinatorial Diversity and their Application to CRISPR-Cas9 Systems

  4DP2NS131566-03
  Alejandro Chavez · UNIVERSITY OF CALIFORNIA, SAN DIEGO, CA · $955,050 · awarded Jan 28, 2026 · NIH

  ABSTRACT For decades, biologists have taken parts from disparate proteins and fused them in various combinations to create engineered variants with user defined properties. Despite the success of many of the generated tools (e.g. chimeric antigen receptors and enhanced CRISPR variants) the methods by which these proteins are discovered are slow and labor…

Compare nearby NIH grant mechanisms

Searchers often land on DP2 while deciding between adjacent NIH activity codes. Compare scope, NIH staff involvement, budget scale, and applicant stage before choosing a funding opportunity.