NIH Grant Search by PI — Funded Principal Investigator Finder

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Enter a research topic, disease, or technology to find principal investigators with NIH funding in that area. To look up a specific PI by name, use the PI Funding Status check.

Search Results

Found 51 principal investigators from 76 displayed projects for "DP2" (2021–2026)

Opportunity Digest

Heuristic scoring to help trainees and job seekers prioritize which labs to inspect first.

1

High-opportunity leads

33

Likely hiring signals

2

Training-friendly awards

32

Average opportunity score

Prioritize records with strong opportunity signals, then validate fit using abstracts, institution pages, and lab websites.

Filter for opportunity type

KARSTEN GRONERT

UNIVERSITY OF CALIFORNIA BERKELEY, BERKELEY, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$624,743
FY 2026

Project Title

Function and Regulation of Constitutive Prostaglandin D2 and DP Receptor Signaling in Retinal Health and Neurodegeneration

Grant Number:

1R01EY036920-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Five distinct prostaglandins are essential lipid mediators and the non-selective inhibition of their formation is the mechanism of action for all NSAIDs. NSAIDs are a routine treatment for ocular allergies, pain, inflammation and macular edema. In sharp contrast, amplification of prostaglandin signa...

Research Terms

<Agonist><Allergy><Ammon Horn><Assay><Astrocytes><Astrocytus><Astroglia><Autoregulation><Axon><Bioassay><Biological Assay><Body Tissues><Cell Body><Cell Communication and Signaling><Cell Death Induction><Cell Signaling><Cells><Chronic><Common Rat Strains><Cornu Ammonis><Cranial Nerve II><Cre-Lox><Cre-LoxP><Cre/LoxP><Data><Dinoprostone><Down-Regulation><Dysfunction><Enzyme Gene><Enzymes><Eye><Eyeball><Functional disorder><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><GPCR><Generations><Genes><Glaucoma><Glutamates><Health><Hippocampus><Homeostasis><Hortega cell><Human><Immunoblotting><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><In Situ Hybridization><Inflammation><Inflammatory><Inner Nuclear Layer><Intracellular Communication and Signaling><Intraocular Pressure><KO mice><Kinases><Knock-out Mice><Knockout Mice><Knowledge><L-Glutamate><Maintenance><Marrow Mast Cell><Mice><Mice Mammals><Microglia><Modeling><Modern Man><Murine><Mus><NSAIDs><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neurocyte><Neuron Degeneration><Neurons><Non-Steroidal Anti-Inflammatory Agents><Null Mouse><Ocular Hypertension><Ocular Tension><Optic Nerve><PGD2><PGE2><PGE2 alpha><PGE2alpha><Pain><Painful><Pathway interactions><Phosphotransferase Gene><Phosphotransferases><Physiologic><Physiologic Intraocular Pressure><Physiological><Physiological Homeostasis><Physiology><Physiopathology><Primates><Primates Mammals><Production><Prostaglandin D2><Prostaglandin E2><Prostaglandin E2 alpha><Prostaglandin E2alpha><Prostaglandin Inhibition><Prostaglandins><Prostanoids><RNA Seq><RNA sequencing><RNAseq><Rat><Rats Mammals><Rattus><Receptor Protein><Receptor Signaling><Regulation><Retina><Role><Second Cranial Nerve><Signal Transduction><Signal Transduction Systems><Signaling><Therapeutic><Tissue Basophils><Tissues><Toxic effect><Toxicities><Trabecular Meshwork><Trabecular meshwork structure><Transphosphorylases><Upregulation><Vascular Diseases><Vascular Disorder><Western Blotting><Western Immunoblotting><allergen response><allergic response><allergy response><astrocytic glia><biological signal transduction><blood vessel disorder><clinical relevance><clinically relevant><frontier><gangliocyte><ganglion cell><gene function><gitter cell><glaucomatous><glutamatergic><hippocampal><in situ Hybridization Genetics><in situ Hybridization Staining Method><interest><intra-ocular pressure><lipid mediator><lipidomics><loss of function><macroglia><macular edema><mast cell><mastocyte><mesoglia><microglial cell><microgliocyte><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neuronal><neuronal degeneration><neuroprotection><neuroprotective><non-human primate><non-steroidal anti-inflammatory drugs><nonhuman primate><novel><ocular hypertensive><pathophysiology><pathway><perivascular glial cell><protein blotting><receptor><response><scRNA sequencing><scRNA-seq><screening><screenings><selective expression><selectively expressed><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><therapeutic target><transcriptome sequencing><transcriptomic sequencing><vascular dysfunction><vasculopathy>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Alia Crum

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$740,750
FY 2026

Project Title

Changing Mindsets to Improve Whole Patient Health: A Randomized Controlled Trial of a Novel mHealth Intervention for People Diagnosed with Cancer

Grant Number:

5R01AT012618-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/19/2024

End Date:

11/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY A cancer diagnosis and its subsequent treatment affects whole patient health -- disrupting the full spectrum of physical, social, emotional, and functional quality of life. An estimated 83% of cancer patients report low to very low quality of life. Individuals receiving chemotherapy ...

Research Terms

<Active Follow-up><Address><Affect><Affective><Anxiety><Award><Behavior><Behavioral><Biological><Biology><Biometrics><Biometry><Biostatistics><Cancer Patient><Cancer Treatment><Cancers><Chronic><Clinical><Cognition Therapy><Cognitive><Cognitive Psychotherapy><Cognitive Therapy><Cognitive treatment><Complex><Decentralization><Development><Diabetes Mellitus><Diagnosis><Diffuse><Disease><Disorder><Dissemination and Implementation><Distress><Emotional><Emotional Depression><Fatigue><Film><Goals><Health><Health Promotion><Hematologic Cancer><Hematologic Malignancies><Hematologic Neoplasms><Hematological Malignancies><Hematological Neoplasms><Hematological Tumor><Hematopoietic Cancer><Hour><Individual><Inflammatory><Intervention><Lack of Energy><Life><Link><Local Therapy><Localized Therapy><Malignant Hematologic Neoplasm><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Measures><Mediating><Medical><Mental Depression><Mental Health><Mental Hygiene><Methods><Mind-Body Intervention><Mind-Body Medicine><NCCAM><NCCIH><NIH><National Center for Complementary and Integrative Health><National Center for Complementary and Integrative Medicine><National Institutes of Health><Nature><Non-metastatic><Nonmetastatic><Oncology><Oncology Cancer><Outcome><Pain><Painful><Participant><Pathway interactions><Patients><Persons><Phase><Physical Function><Physical activity><Physiologic><Physiological><Physiology><Psychiatry><Psychological Health><Psychology><QOL><QOL improvement><Quality of life><Randomized, Controlled Trials><Reporting><Research><SYS-TX><Salutogenesis><Sleep><Social Functioning><Solid Neoplasm><Solid Tumor><Supportive Therapy><Supportive care><Symptoms><Systemic Therapy><Testing><Time><United States National Institutes of Health><active followup><anti-cancer therapy><anxiety symptoms><anxious symptom><associated symptom><attentional control><biologic><cancer diagnosis><cancer therapy><cancer-directed therapy><care as usual><chemotherapy><chronic pain><clinical care><co-morbid symptom><co-occuring symptom><cognitive behavior intervention><cognitive behavior modification><cognitive behavior therapy><cognitive behavioral intervention><cognitive behavioral modification><cognitive behavioral therapy><cognitive behavioral treatment><comorbid symptom><concurrent symptom><cooccuring symptom><coping><cost><cost efficient><depression><depression symptom><depressive><depressive symptoms><developmental><diabetes><digital><digital delivery><digitally deliver><emotional functioning><experience><follow up><follow-up><followed up><followup><function socially><functional restoration><functioning social><improved><improvements in QOL><improvements in quality of life><indexing><intervention effect><m-Health><mHealth><mHealth therapeutic><mHealth therapy><mHealth treatment><malignancy><mhealth interventions><mind body approach><mind body medicine skills><mind body techniques><mind body therapy><mind body treatments><mind body wellness><mind/body><mindfulness-based stress reduction><mobile health><mobile health intervention><mobile health therapeutic><mobile health therapy><mobile health treatment><neoplasm/cancer><novel><osteoarthritis associated pain><osteoarthritis pain><pathway><patient centered><patient oriented><physical symptom><primary outcome><programs><promoting health><psychologic><psychological><psychological symptom><quality of life improvement><randomized control trial><restore function><restore functionality><restore lost function><routine care><secondary outcome><sleep difficulty><social><symptom association><symptom comorbidity><tool><treatment as usual><usual care><whole health><whole person health>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Amnon Koren

ROSWELL PARK CANCER INSTITUTE CORP, BUFFALO, NY

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$458,040
FY 2026

Project Title

The Genetic Basis of Human DNA Replication Timing

Grant Number:

5R35GM148071-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY / ABSTRACT DNA replication follows a defined spatiotemporal program in which different parts of the genome replicate at different times during S phase. The DNA replication timing program interfaces with genome regulation while also influencing the genome’s stability and mutational la...

Research Terms

<Assay><Award><Bioassay><Biological Assay><Biology><Cell Body><Cell Differentiation><Cell Differentiation process><Cells><Chromosome Mapping><Communication><DNA Replication><DNA Replication Timing><DNA Sequence><DNA Synthesis><DNA biosynthesis><DNA mutation><Data Set><Development><Elements><Experimental Genetics><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Localization><Gene Mapping><Gene Mapping Genetics><Gene Regulation><Gene Regulation Process><Genes><Genetic><Genetic Change><Genetic Diseases><Genetic Diversity><Genetic Variation><Genetic defect><Genetic mutation><Genome><Genome Stability><Genomic Stability><Genomic approach><Human><Human Genetics><Link><Linkage Mapping><Measures><Modern Man><Molecular><Mutation><NIH><National Institutes of Health><Nature><Oncogenesis><Other Genetics><Regulation><S Period><S phase><Specific qualifier value><Specified><Synthesis Period><Synthesis Phase><Temporal DNA Replication Order><Temporal DNA Replication Pattern><Total Human and Non-Human Gene Mapping><United States National Institutes of Health><Work><cancer genetics><cellular differentiation><developmental><epigenome><epigenomics><genetic approach><genetic condition><genetic disorder><genetic mapping><genetic strategy><genome mutation><genome resource><genome scale><genome-wide><genomewide><genomic data resource><genomic effort><genomic resource><genomic sequencing resource><genomic strategy><human DNA><insight><new approaches><novel><novel approaches><novel strategies><novel strategy><programs><spatial and temporal><spatial temporal><spatiotemporal><success><tumorigenesis>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Mark Yarmarkovich

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Good lead · 60/100
Likely hiring
Large award
Active award
$1,525,500
FY 2024

Project Title

Expanding CAR T cell applications through high-throughput forward- and reverse immune engineering

Grant Number:

1DP2CA301080-01

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2024

End Date:

8/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Adaptive immunity is one of the most complex and clinically relevant aspects of human biology, where immune cells have evolved over millions of years to discriminate non-self from self, and the dangerous from the innocuous. Though cancer cells pose an intrinsic danger to an organism, their derivatio...

Research Terms

<Address><Antigens><Award><CAR T cells><CAR modified T cells><CAR-T><CAR-Ts><Cancer Patient><Cancer Treatment><Cancers><Cell Body><Cells><Checkpoint inhibitor><Clinical Trials><Complex><Computing Methodologies><Dangerousness><Derivation><Derivation procedure><Development><Eligibility><Eligibility Determination><Engineering><Generations><Genetic Alteration><Genetic Change><Genetic defect><Human Biology><Immune><Immune Evasion><Immune checkpoint inhibitor><Immune mediated therapy><Immune response><Immunes><Immunological response><Immunologically Directed Therapy><Immunotherapy><Libraries><Logic><Malignant Cell><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Methods><Mutation><NIH><National Institutes of Health><Nature><Organism><Patients><Peptides><Population><Pre-Clinical Model><Preclinical Models><Process><Protocol Screening><Receptor Protein><Research><Reverse engineering><Solid Neoplasm><Solid Tumor><System><T cells for CAR><Tumor Antigens><Tumor-Associated Antigen><United States National Institutes of Health><Work><adaptive immunity><anti-cancer therapy><cancer antigens><cancer cell><cancer therapy><cancer-directed therapy><chimeric antigen T cell receptor><chimeric antigen receptor><chimeric antigen receptor (CAR) T cells><chimeric antigen receptor T cells><chimeric antigen receptor fusion protein T-cells><chimeric antigen receptor modified T cells><clinical relevance><clinically relevant><computational methodology><computational methods><computer based method><computer methods><computing method><cross reactivity><developmental><engineered immune system><experience><genome mutation><high reward><high risk><host response><immune check point inhibitor><immune engineering><immune evasive><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunoengineering><immunogen><immunoresponse><in silico><innovate><innovation><innovative><leukemia><living system><malignancy><neoplasm/cancer><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new technology><new therapeutics><new therapy><next generation therapeutics><novel><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel technologies><novel therapeutics><novel therapy><patient population><patient response><patient specific response><process improvement><receptor><refractory cancer><resistant cancer><responsive patient><screening><screenings><success><therapeutically effective><tool><tumor><tumor-specific antigen>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Dian Yang

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 60/100
Likely hiring
Large award
Active award
$1,480,500
FY 2024

Project Title

Towards a Comprehensive, Spatiotemporal Roadmap of Cancer Metastasis

Grant Number:

1DP2CA301079-01

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2024

End Date:

8/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

PROJECT SUMMARY Cancer metastasis, which accounts for 8 million deaths worldwide annually, is a multistep process that includes the emergence of metastatic subclones in primary tumors, dissemination and survival in circulation, seeding and colonization at distant sites. Deciphering the evolutionary ...

Research Terms

<Biological><Cell Body><Cell Communication and Signaling><Cell Lineage><Cell Signaling><Cells><Cessation of life><Circulation><Clinical><Death><Dissection><Disseminated Malignant Neoplasm><Distant><Environment><Event><Evolution><Future><GEM model><GEMM model><Gene Expression><Gene Transcription><Generations><Genes><Genetic Transcription><Genetically Engineered Mouse><Goals><Intracellular Communication and Signaling><Malignant Tumor of the Lung><Malignant neoplasm of lung><Maps><Metastasis><Metastasize><Metastatic Cancer><Metastatic Lesion><Metastatic Malignant Neoplasm><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Molecular><Nature><Neoplasm Metastasis><Neuroendocrine><Neuroendocrine System><Neurosecretory Systems><Oat cell carcinoma><Phase><Primary Neoplasm><Primary Tumor><Process><Pulmonary Cancer><Pulmonary malignant Neoplasm><RNA Expression><Resolution><Sampling><Secondary Neoplasm><Secondary Tumor><Signal Transduction><Signal Transduction Systems><Signaling><Site><Small Cell Lung Cancer><Technology><Therapeutic><Time><Transcription><Work><biologic><biological signal transduction><cancer metastasis><cancer type><genetically engineered mouse model><genetically engineered murine model><insight><lung cancer><lung oat cell carcinoma><lung small cell neuroendocrine carcinoma><mouse model><murine model><new technology><novel><novel technologies><oat cell cancer><resolutions><small cell lung carcinoma><small cell undifferentiated carcinoma><spatiotemporal><therapeutic agent development><therapeutic development><therapeutically effective><transcriptomics><tumor><tumor cell metastasis>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Richard S Smith

NORTHWESTERN UNIVERSITY AT CHICAGO, CHICAGO, IL

Good lead · 60/100
Likely hiring
Large award
Active award
$1,440,000
FY 2025

Project Title

Perinatal brain therapeutics: a high throughput biology approach to build next generation RNA precision medicines

Grant Number:

1DP2NS148744-01

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2025

End Date:

7/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Project Summary Early electrical patterns in the human brain guide development, and even slightly disrupted electrical activity can result in severe neurodevelopmental diseases. Epilepsy alone affects ~3.5 million individuals in the United States, including ~450,000 children (CDC). For children wit...

Research Terms

<0-11 years old><3-D><3-Dimensional><3D><Acquired brain injury><Affect><Anticonvulsant Agent><Anticonvulsant Drugs><Anticonvulsants><Anticonvulsive Agents><Anticonvulsive Drugs><Antisense Agent><Antisense Oligonucleotides><Biology><Birth><Boston><Brain><Brain Injuries><Brain Nervous System><Calcium><Cell Body><Cell Culture Techniques><Cells><Cerebrum><Chemistry><Child><Child Youth><Childhood><Children (0-21)><Children's Hospital><Collaborations><Complex><Data Set><Development><Disease><Disorder><Encephalon><Epilepsy><Epileptic Seizures><Epileptics><Evaluation><FDA approved><Fetal Therapies><Food and Drug Administration><Human><Individual><Inequity><Infant><K channel><Lifelong disability><Machine Learning><Modality><Modeling><Modern Man><Modern Medicine><Monitor><Neocortex><Nerve Cells><Nerve Unit><Neural Cell><Neurobiology><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><Non-Polyadenylated RNA><Onset of illness><Operative Procedures><Operative Surgical Procedures><Organoids><Parturition><Pathway interactions><Pattern><Pediatric Hospitals><Perinatal><Peripartum><Permanent disability><Physiologic><Physiological><Potassium Channel><Potassium Ion Channels><RNA><RNA Gene Products><RNA based therapeutics><RNA based therapy><RNA therapy><Research Resources><Resistance><Resources><Ribonucleic Acid><Schistorrhachis><Seizure Disorder><Spina Bifida><Spinal Dysraphia><Spinal Dysraphism><Surgical><Surgical Interventions><Surgical Procedure><Syndrome><Techniques><Therapeutic><Time><USFDA><United States><United States Food and Drug Administration><antisense oligo><brain cell><brain damage><brain-injured><cell culture><cell cultures><cell type><cerebral><cleft spine><cost><critical period><design><designing><develop therapy><developmental><disease onset><disorder onset><effective therapy><effective treatment><epilepsia><epileptogenic><excitotoxic><excitotoxicity><fetus therapy><frontier><homotypical cortex><hydrocele spinalis><improved><in silico><in utero><in utero therapy><in vitro Model><individual patient><intervention development><isocortex><kids><machine based learning><monolayer><neocortical><neopallium><neurobiological><neurodevelopmental disease><neuronal><neurophysiological><neurophysiology><next generation><pathway><patient population><pediatric><perinatal brain><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><precision medicine><precision-based medicine><prenatal therapy><prevent><preventing><programs><rachischisis posterior><resilience><resilient><resistant><response><seizure drug><seizure medication><surgery><technology platform><technology system><therapeutic RNA><therapeutic target><therapy development><three dimensional><treatment development><voltage><youngster>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Elizabeth Erin Crouch

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 60/100
Likely hiring
Large award
Active award
$1,388,925
FY 2023

Project Title

Vascular mural cells in the development of the blood brain barrier

Grant Number:

1DP2MH136391-01

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2023

End Date:

8/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

PROJECT ABSTRACT/SUMMARY Brain blood vessel cells play key roles in both physiological and pathological states. Endothelial and mural cells compose the main structural and functional elements of the vasculature. Situated between the endothelial cell lumen and the surrounding astrocytes, microglia, ...

Research Terms

<21+ years old><2nd trimester><Adult><Adult Human><Adventitial Cell><Age><Astrocytes><Astrocytus><Astroglia><Atlases><Blood - brain barrier anatomy><Blood Cells><Blood Vessels><Blood flow><Blood-Brain Barrier><Body Tissues><Brain><Brain Nervous System><Cell Body><Cell Communication and Signaling><Cell Function><Cell Process><Cell Signaling><Cell physiology><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cerebrovascular system><Consumption><Data><Detection><Development><Disease><Disorder><Effector Cell><Elements><Embryo><Embryonic><Encephalon><Endothelial Cells><Endothelium><Fibroblasts><Fluorescence Activated Cell Sorting Fractionation><Fluorescence-Activated Cell Sorting><Fluorescence-Activated Cell Sortings><Future><Genetic><Goals><Hemato-Encephalic Barrier><Heterogeneity><Hortega cell><Human><Intracellular Communication and Signaling><Knowledge><Lead><Leiomyocyte><Mice><Mice Mammals><Microglia><Midtrimester><Mitotic><Modern Man><Molecular><Murine><Mus><Neonatal><Nerve Cells><Nerve Unit><Nervous System Physiology><Neural Cell><Neurocyte><Neurologic function><Neurological function><Neurons><Non-Polyadenylated RNA><Pathologic><Patients><Pb element><Pericapillary Cell><Pericytes><Peripheral Blood Cell><Perivascular Cell><Physiologic><Physiological><Play><Progenitor Cells><Proteins><RNA><RNA Gene Products><Reporting><Ribonucleic Acid><Role><Rouget Cells><Second Pregnancy Trimester><Second Trimester><Signal Transduction><Signal Transduction Systems><Signaling><Smooth Muscle Cells><Smooth Muscle Myocytes><Smooth Muscle Tissue Cell><Subcellular Process><Time><Tissues><adulthood><ages><astrocytic glia><biological signal transduction><blood vessels in the brain><bloodbrain barrier><brain blood vessels><brain cell><brain vasculature><cerebral blood vessel><cerebral vasculature><cerebrovascular vessels><cerebrovasculature><developmental><experiment><experimental research><experimental study><experiments><gitter cell><heavy metal Pb><heavy metal lead><mesoglia><microglial cell><microgliocyte><nervous system function><neuro-vascular><neuro-vascular unit><neuronal><neurovascular><neurovascular unit><perivascular glial cell><prenatal><progenitor><response><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><spatiotemporal><stem cells><transcriptomics><treatment strategy><unborn><vascular>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Danielle Arigo

ROWAN UNIVERSITY, GLASSBORO, NJ

Good lead · 60/100
Likely hiring
Large award
Active award
$1,336,496
FY 2023

Project Title

A Paradigm Shift in Health Behavior Change: Understanding When and How Social Comparison Supports Healthy Behavior

Grant Number:

1DP2HL173857-01

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2023

End Date:

8/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Abstract Prompts to evaluate ourselves relative to others (i.e., social comparison) are increasingly engineered into our daily lives to promote specific behaviors, including in digital health technologies and health behavior change interventions. Despite its ubiquity, however, we do not yet understa...

Research Terms

<21+ years old><Adult><Adult Human><Affect><Area><Award><Behavior><Behavioral Sciences><Chronic Disease><Chronic Illness><Engineering><Environment><Evidence based practice guidelines><Experimental Designs><Health Care Technology><Health Technology><Health behavior><Health behavior and outcomes><Health behavior change><Healthcare Technology><Intervention><Intervention Strategies><Life><Link><Methods><Pathway interactions><Persons><Physical activity><Public Health><Randomized><Research><Series><Testing><Theoretic Models><Theoretical model><Work><adulthood><chronic disorder><digital health><disease prevention><disorder prevention><evidence based guidelines><evidence based recommendations><health related behavior><innovate><innovation><innovative><interventional strategy><new approaches><novel><novel approaches><novel strategies><novel strategy><pathway><randomisation><randomization><randomly assigned><social>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Jacqueline A Palmer

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Good lead · 60/100
Likely hiring
Large award
Active award
$1,311,772
FY 2025

Project Title

Neuroplasticity and cerebral blood flow as key resilience mechanisms in the brains of fast-moving SuperAgers

Grant Number:

1DP2AG101104-01

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2025

End Date:

8/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Project Summary: The gradual loss of physical and cognitive ability has been taken as the near-universal consequence of growing older. Older adults slow down physically, with reduced gait speed and increased instability, and slow cognitively, with declining memory and executive function. Disease pat...

Research Terms

<Acceleration><Age><Aging><Amentia><American><Amyloid><Amyloid Substance><Autopsy><Behavioral><Biomechanics><Blood Flow Velocity><Blood Vessels><Brain><Brain Nervous System><Brain Vascular><CNS plasticity><Cerebrovascular Circulation><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Data><Degenerative Neurologic Disorders><Dementia><Development><Disease><Disorder><Disturbance in cognition><Doppler Transcranial Sonography><Drugs><EEG><Electroencephalogram><Electroencephalography><Encephalon><Equilibrium><Future><Gait speed><Glean><Goals><Health><Human><Immediate Memory><Impaired cognition><Intervention><Knowledge><Learning><Length of Life><Longevity><Measures><Medication><Memory Loss><Modern Man><Movement><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurobiology><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuronal Plasticity><Neurosciences><Pathology><Persons><Pharmaceutical Preparations><Phenotype><Physical Function><Physiologic><Physiological><Research><Short-Term Memory><Speed><System><Testing><Time><Transcranial Doppler Ultrasonography><Walking><aged brain><ages><aging brain><aging prevention><anti aging><anti geronic><antiaging><balance><balance function><biomechanical><blood flow in brain><body movement><brain blood circulation><brain blood flow><central nervous system plasticity><cerebral blood flow><cerebral circulation><cerebral vascular><cerebro-vascular><cerebrocirculation><cerebrovascular><cerebrovascular blood flow><cognitive ability><cognitive dysfunction><cognitive function><cognitive loss><cohort><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><drug/agent><executive control><executive function><improved><innovate><innovation><innovative><lens><lenses><memory decline><multi-modality><multimodality><necropsy><neural><neural imaging><neural plasticity><neuro-imaging><neurobiological><neurodegenerative illness><neuroimaging><neurological imaging><neuroplastic><neuroplasticity><neuroprotection><neuroprotective><novel><older adult><older adulthood><peer><postmortem><prevent><prevent age related><prevent aging><preventing><resilience><resilient><response><super ager><suppress aging><transcranial doppler ultrasound><vascular><walking pace><walking speed><working memory>
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Kiera L. Clayton

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$502,500
FY 2025

Project Title

Characterizing Macrophages as "Hide-Outs" for Chronic Pathogens

Grant Number:

5DP2AI154438-05

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2021

End Date:

7/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY This proposal describes the framework of an NIAID New Innovators DP2 award for Kiera Clayton, PhD. Dr. Clayton is currently a postdoctoral fellow under the supervision of Dr. Bruce Walker at the Ragon Institute of MGH, MIT and Harvard, whose current research focuses on T cell and NK ...

Research Terms

<AIDS><AIDS Virus><Acquired Immune Deficiency><Acquired Immune Deficiency Syndrome><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome><Acquired Immunodeficiency Syndrome Virus><Address><Anti-Retroviral Agents><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Antigens><Apoptosis><Apoptosis Pathway><Area><Award><Body Tissues><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CD94 Antigen><CMV><Candidate Disease Gene><Candidate Gene><Cardiovascular Diseases><Caspase><Caspase Gene><Cell Body><Cell Communication><Cell Death><Cell Interaction><Cell-Death Protease><Cell-Mediated Lympholytic Cells><Cell-to-Cell Interaction><Cells><Cessation of life><Characteristics><Chronic><Cysteine Endopeptidases><Cysteine Protease><Cysteine Proteinases><Cytolytic T-Cell><Cytomegalovirus><Cytotoxic T Cell><Cytotoxic T-Lymphocytes><Cytotoxic cell><Data><Death><Development><Doctor of Philosophy><Drugs><Exhibits><Expression Signature><Failure><Future><Gene Expression Profile><Goals><Granzyme><HCMV><HIV><HIV Infections><HIV/Mtb><HIV/TB><HIV/mycobacterium tuberculosis><HIV/tuberculosis><HTLV-III Infections><HTLV-III-LAV Infections><Hepatic Disorder><Human><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Infections><ICE-like protease><Immune><Immune Evasion><Immune response><Immunes><Immunity><Immunology><Individual><Induction of Apoptosis><Infection><Inflammation><K lymphocyte><KLRD1 Protein><Killer Cell Lectin-Like Receptor Subfamily D, Member 1><Killer Cell Lectin-Like Receptor Subfamily D, Member 1 Isoforms 1, 2><Killer Cell Lectin-Like Receptor Subfamily D, Member 1 Protein><Knock-out><Knockout><Kp43 antigen><LAV-HTLV-III><Laboratories><Ligands><Liver diseases><Lymphadenopathy-Associated Virus><M tb><M tuberculosis><M tuberculosis infection><M. tb><M. tb infection><M. tuberculosis><M. tuberculosis infection><M. tuberculosis/HIV><M.tb infection><M.tuberculosis infection><MTB infection><Macrophage><Mediating><Medication><Methods><Miscellaneous Antibiotic><Mission><Modern Man><Mycobacterium tuberculosis><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><Mφ><NIAID><NK Cell Receptor><NK Cells><NK receptor><National Institute of Allergy and Infectious Disease><Natural Killer Cells><Natural Killer Cells Antigen CD94><Nature><Pathway interactions><Penetrance><Ph.D.><PhD><Pharmaceutical Preparations><Postdoc><Postdoctoral Fellow><Predisposition><Productivity><Programmed Cell Death><Proteins><Publishing><Research><Research Associate><Resistance><Salivary Gland Viruses><Supervision><Susceptibility><T cell response><T-Cells><T-Lymphocyte><T-Lymphocyte and NK-Cell><T-Lymphocyte and Natural Killer Cell><T4 Cells><T4 Lymphocytes><TB infection><Tissues><Tuberculosis><Viral><Virus><Virus-HIV><Work><anti-retroviral><antigen-specific T cells><antiretroviral therapy><antiretroviral treatment><cardiovascular disorder><cell killing><cell type><co-morbid><co-morbidity><comorbidity><cystein protease><cystein proteinase><cysteine endopeptidase><cytokine><cytomegalovirus group><cytotoxic CD8 T cells><cytotoxic CD8 T lymphocyte><design><designing><develop therapy><developmental><disseminated TB><disseminated tuberculosis><drug/agent><gene expression pattern><gene expression signature><hepatic disease><hepatopathy><host response><immune evasive><immune system response><immunogen><immunoresponse><infection due to Mycobacterium tuberculosis><inhibitor><innovate><innovation><innovative><insight><intervention design><intervention development><killer T cell><liver disorder><mtb><necrocytosis><neutralizing antibody><pathogen><pathway><post-doc><post-doctoral><post-doctoral trainee><prevent><preventing><programs><research associates><resistant><response><side effect><systemic inflammation><systemic inflammatory response><therapeutic agent development><therapeutic development><therapy design><therapy development><thymus derived lymphocyte><transcriptional profile><transcriptional signature><treatment design><treatment development><tuberculosis infection><tuberculous spondyloarthropathy><virological synapse><virology>
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Samuel M Wu

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Good lead · 52/100
Likely hiring
Above-average budget
Team-scale grant
$632,674
FY 2024

Project Title

P30 - Core Grant for Vision Research

Grant Number:

5P30EY002520-45

Activity Code:

P30

Mechanism:

Research Centers

Agency:

NIH

Start Date:

7/1/1997

End Date:

6/30/2025

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Overall The objective of the Core Grant for Vision Research is to provide support and facilities, which are not available and cannot be obtained through individual grants, exclusively for vision research and NEI-funded projects at Baylor College of Medicine (BCM). The Core also provides spa...

Research Terms

<2-dimensional><3-D Imaging><3D imaging><Age related macular degeneration><Age-Related Maculopathy><Amblyopia><Animals><Area><Bio-Informatics><Biochemical><Biochemistry><Bioinformatics><Biological Chemistry><Body Tissues><Cell Body><Cells><Chimera Protein><Chimeric Proteins><Chromium><Collaborations><Common Rat Strains><Complex><Computer software><Computers><Confocal Microscopy><Core Facility><Core Grant><Cornea><Cr element><Custom><Dedications><Developmental Biology><Devices><Discipline><Disease><Disorder><Domestic Rabbit><Dysfunction><Electron Microscope><Electron Microscopy><Electronics><Electrophysiology><Electrophysiology (science)><Eligibility><Eligibility Determination><Environment><Equipment><Equipment Design><Eye><Eyeball><Fluorescence Agents><Fluorescent Agents><Fluorescent Dyes><Fostering><Functional disorder><Funding><Fusion Protein><Generations><Genes><Genetic Alteration><Genetic Change><Genetic defect><Genomics><Glaucoma><Grant><HPLC><High Performance Liquid Chromatography><High Pressure Liquid Chromatography><High Speed Liquid Chromatography><Histologic><Histologically><Histology><Human Resources><Image><Immunofluorescence><Immunofluorescence Immunologic><Individual><Institution><Investigators><Joints><Label><Laboratory Research><Light Microscope><Manpower><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mechanics><Medicine><Mice><Mice Mammals><Microscope><Microscopy><Molecular><Molecular Genetics><Murine><Mus><Mutation><NIH><National Institutes of Health><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Nucleic Acids><Ophthalmology><Optics><Oryctolagus cuniculus><Paper><Pathogenesis><Phorias><Physiologic><Physiological><Physiopathology><Pigmentary Retinopathy><Postdoc><Postdoctoral Fellow><Process><Productivity><Proteins><Protocol Screening><Psychophysics><Publications><Publishing><R-Series Research Projects><R01 Mechanism><R01 Program><Rabbits><Rabbits Mammals><Rat><Rats Mammals><Rattus><Reagent><Reporting><Research><Research Associate><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Resources><Research Training><Researchers><Resolution><Resources><Retina><Retinitis Pigmentosa><Scanning><Scientific Publication><Services><Sight><Software><Squint><Strabismus><Structure><Students><Synapses><Synaptic><System><Systems Analyses><Systems Analysis><Tapetoretinal Degeneration><Technology><Thick><Thickness><Three-Dimensional Imaging><Time><Tissue imaging><Tissues><Training><Transmission><United States National Institutes of Health><Vision><Vision research><Visual><Visual System><age dependent macular degeneration><age induced macular degeneration><age related macular disease><age related macular dystrophy><behavior test><behavioral test><college><collegiate><computer imaging><computerized><corneal><customs><design><design and construct><design and construction><designing><digital imaging><electronic><electronic device><electrophysiological><experience><fabrication><flexibility><flexible><fluorescent dye/probe><genome mutation><genome profiling><genomic profiling><glaucomatous><human genome sequencing><imaging><improved><innovate><innovation><innovative><instrumentation><lens><lenses><mechanic><mechanical><neural><neuronal><optical><patch clamp><pathophysiology><personnel><post-doc><post-doctoral><post-doctoral trainee><programs><psychophysical><recruit><research associates><research facility><research faculty><resolutions><rod and cone dystrophy><rod-cone dystrophy><senile macular disease><single cell genomics><sq. ft><square foot><synapse><transmission process><two-dimensional><visual function><visual neuroscience><water maze>
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Robert Koehler Abbott

UNIVERSITY OF TEXAS MED BR GALVESTON, GALVESTON, TX

Good lead · 52/100
Likely hiring
Solid budget
Active award
$480,000
FY 2026

Project Title

Revealing the Biophysics of the Germinal Center Microenvironment

Grant Number:

5DP2AI154410-05

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/22/2021

End Date:

11/30/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Abstract Is an HIV vaccine possible? Vaccines are one of the most successful public health interventions over the past century. Nearly all vaccines work by induction of protective antibodies. However, our understanding of the cellular dynamics of immune responses to vaccines, particularly the biolog...

Research Terms

<A2AR><ADORA2><ADORA2A gene><AIDS Vaccines><AIDS Virus><AIDS vaccine><Achievement><Achievement Attainment><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Adenosine><Adenosine A(2A) Receptor><Adenosine A2A Receptor><Adenosine Receptors><Affect><Affinity><Animal Model><Animal Models and Related Studies><Antibodies><Antibody Response><Antigenic Determinants><Antigens><Autoimmune Status><Autoimmunity><Avidity><B blood cells><B cell><B cell receptor><B cells><B-Cell Activation><B-Cell Antigen Receptor><B-Cells><B-Lymphocytes><B-cell><Binding Determinants><Biologic Models><Biological Models><Biology><Biophysics><Cell Communication and Signaling><Cell Culture Techniques><Cell Signaling><Cell model><Cellular biology><Cellular model><Characteristics><Clone Cells><Coin><Complex><Cues><Drug Therapy><Engineering><Env trimer><Epitopes><Event><Extracellular Space><Frequencies><Future><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><GPCR><Generations><Genes><Germ Lines><Germinal Center><Goals><HIV><HIV Env><HIV Seronegativities><HIV Seronegativity><HIV envelope><HIV envelope protein><HIV glycoprotein Env><HIV individuals><HIV infected individuals><HIV infected persons><HIV negative><HIV people><HIV positive individuals><HIV positive people><HIV vaccine><HIV-1 Env><HIV-1 envelope><HIV-1 glycoprotein Env><HIV/AIDS Vaccines><HTLV-III Seronegativities><HTLV-III Seronegativity><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Human><Human Immunodeficiency Viruses><Hypoxia><Hypoxic><Hypoxic tumor><Ig Somatic Hypermutation><Immune response><Immunization><Immunochemical Immunologic><Immunoglobulin Somatic Hypermutation><Immunologic><Immunological><Immunologically><Immunologics><Immunomodulation><In Vitro><Individual><Inducer Cells><Inducer T-Lymphocytes><Influenza HA><Influenza Hemagglutinin><Intercellular Space><Intracellular Communication and Signaling><Island><Knowledge><LAV-HTLV-III><Learning><Licensing><Lymphadenopathy-Associated Virus><Measurement><Measures><Metabolic><Metabolic Pathway><Mice><Mice Mammals><Microdialysis><Microscopic><Model System><Modeling><Modern Man><Murine><Mus><Mutate><Nature><Outcome><Oxygen Deficiency><P1 Purinoceptors><P50 Mechanism><P50 Program><PLWH><PWH><Pathway interactions><Pharmacological Treatment><Pharmacotherapy><Phase><Phylogenetic Analysis><Phylogenetics><Physiologic><Physiological><Play><Population><Purinergic P1 Receptors><RDC8><Reaction><Role><Series><Signal Transduction><Signal Transduction Systems><Signaling><Specialized Center><Structure><Structure of germinal center of lymph node><System><Temperature><VEGF><VEGFs><Vaccination><Vaccine Antigen><Vaccine Design><Vaccines><Vascular Endothelial Growth Factors><Virus><Virus-HIV><Work><activated B cells><biological signal transduction><biophysical characteristics><biophysical characterization><biophysical foundation><biophysical measurement><biophysical parameters><biophysical principles><biophysical properties><biophysical sciences><cancer microenvironment><cell biology><cell culture><cell cultures><design><designing><drug intervention><drug treatment><extracellular><fitness><flu HA><flu hemagglutinin><host response><human immunodeficiency virus vaccine><immune modulation><immune regulation><immune response to vaccination><immune response to vaccines><immune system response><immunogen><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><improved><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><influenza viral HA><influenza viral hemagglutinin><influenza virus HA><influenza virus hemagglutinin><insight><interest><model of animal><multi-photon><neutralizing antibody><novel><pathway><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><pressure><public health intervention><recruit><response><small molecule><social role><somatic hypermutation><success><tumor hypoxia><tumor microenvironment><vaccine against HIV><vaccine associated immune response><vaccine immune response><vaccine immunogenicity><vaccine induced immune response>
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CHENG ZHANG

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$419,909
FY 2026

Project Title

Structure, pharmacology and signaling of G protein-coupled receptors (GPCRs) in inflammation

Grant Number:

5R35GM128641-08

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2018

End Date:

12/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Inflammation is a complex process with many lipid and peptide mediators involved. A large number of these mediators elicit either pro-inflammatory or pro-resolving effects through the action on G protein-coupled receptors (GPCRs). My lab is interested in the molecular mechanisms by w...

Research Terms

<ALXR><Address><Agonist><Biology><C5a Receptors><C5a anaphylatoxin receptor><CD88 Antigens><CHEMERINR><CHEMR23><CMKLR1><CMKLR1 gene><Cell Communication and Signaling><Cell Signaling><Cell membrane><Chemerin Receptor><Chemicals><Chemoattractant Receptor><Chemokine Like Receptor 1><Chemotactic Peptide Receptor><Complement 5a Receptor><Complex><Computational Biology><Cryo-electron Microscopy><Cryoelectron Microscopy><Cytoplasmic Membrane><D2 receptor><DRD2 Receptor><Development><Disease><Disorder><Dopamine D2 Receptor><Drug Controls><Drugs><Electron Cryomicroscopy><F-Chemotactic Peptide Receptor><FPR2><FPR2 gene><FPRH1><FPRL1><Family><Fatty Acids><Formyl Peptide Receptor 2><Formyl Peptide Receptor Homolog 1><Formyl Peptide Receptor-Like 1><Formyl Peptide Receptors><Funding><Future><G Protein-Complex Receptor><G Protein-Coupled Receptor 32><G Protein-Coupled Receptor Genes><G Protein-Coupled Receptor Signaling><G-Protein-Coupled Receptors><GPCR><GPCR Signaling><GPR32><GPR32 gene><GPR84><GPR84 gene><HM63><Inflammation><Inflammatory><Inflammatory Response><Intracellular Communication and Signaling><LXA4R><Ligands><Lipids><Lipoxin A4 Receptor><Macrophage><Mediator><Medication><Medium chain fatty acid><Molecular><Molecular Configuration><Molecular Conformation><Molecular Stereochemistry><Mφ><N-3 polyunsaturated fatty acid><N-Formylmethionyl Peptide Receptor><N-formyl Hexapeptide Receptor><New Agents><Omega-3 Fatty Acids><Omega-3 PUFA><Omega-3 Polyunsaturated Fatty Acid><PGD2><Peptides><Phagocytosis><Pharmaceutical Preparations><Pharmacology><Plasma Membrane><Process><Property><Prostaglandin D2><Receptor Protein><Research><Resolution><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Structure><antagonism><antagonist><biological signal transduction><computer biology><conformation><conformational><conformational state><conformationally><conformations><cryo-EM><cryoEM><cryogenic electron microscopy><developmental><drug candidate><drug/agent><fMet-Leu-Phe receptor><interest><member><n-3 Fatty Acids><n-3 PUFA><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><omega-3><omega-3s><pharmacologic><plasmalemma><receptor><receptor binding><receptor bound><receptor function><resolutions><small molecule><structural biology><targeted agent><tool>
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Allison Michelle Andrews

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Good lead · 50/100
Likely hiring
Large award
$1,699,969
FY 2022

Project Title

HIV and Cocaine Drive Bone-Marrow Blood (BMB) Barrier Dysfunction and Altered Hematopoietic Stem Cell (HSC) Differentiation Leading to Cardiovascular Disease

Grant Number:

7DP2DA056172-02

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

People living with HIV (PLWH), even with anti-retroviral therapy (ART), have an accelerated and augmented onset of non-AIDS related diseases such as the premature development of cardiovascular disease (CVD). In fact, CVD has become the second most common cause of non-AIDS related mortality in PLWH i...

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Gaurav Das Gaiha

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 46/100
Likely hiring
Solid budget
Active award
$499,920
FY 2024

Project Title

Exploiting Highly Networked CTL Epitopes to Achieve a Functional HIV Cure

Grant Number:

5DP2AI154421-05

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2020

End Date:

8/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT The HIV/AIDS epidemic continues to have enormous medical, societal and economic implications worldwide. While combination anti-retroviral therapy (cART) has greatly reduced the global burden of HIV, the ability of the virus to establish a persistent reservoir within the body requires that H...

Research Terms

<AIDS Virus><AIDS/HIV><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Adoptive Transfer><Algorithms><Alleles><Allelomorphs><Anatomic Sites><Anatomic structures><Anatomy><Antigenic Determinants><Area><Binding Determinants><Blood><Blood Reticuloendothelial System><Body Tissues><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cell Body><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cell-Mediated Lympholytic Cells><Cells><Chronic><Clone Cells><Co-culture><Cocultivation><Coculture><Coculture Techniques><Collaborations><Core Facility><Cytolysis><Cytolytic T-Cell><Cytotoxic T Cell><Cytotoxic T-Lymphocytes><DNA><Data><Deoxyribonucleic Acid><Drug resistance><Drug toxicity><Drugs><Effectiveness><Epidemic><Epitopes><Fellowship><Genetic Alteration><Genetic Change><Genetic defect><Genetics-Mutagenesis><Goals><HIV><HIV vaccine><HIV/AIDS><HIV/AIDS Vaccines><Human Immunodeficiency Viruses><Impairment><Individual><Investigation><Investments><Knowledge><LAV-HTLV-III><Life><Link><Lymphadenopathy-Associated Virus><Lysis><Mediating><Medical><Medication><Methodology><Mission><Modality><Mutagenesis><Mutagenesis Molecular Biology><Mutate><Mutation><NIH><National Institutes of Health><Network Analysis><Pathway Analysis><Patients><Pharmaceutical Preparations><Postdoc><Postdoctoral Fellow><Progressive Disease><Proteome><Public Health><Publishing><Research><Research Associate><Research Resources><Resources><Rest><Science><Site><Structure><T cell based therapeutics><T cell based therapy><T cell directed therapies><T cell response><T cell targeted therapeutics><T cell therapy><T-Cell Epitopes><T-Lymphocyte Epitopes><T-cell therapeutics><T-cell transfer therapy><T4 Cells><T4 Lymphocytes><Therapeutic><Tissue Sample><Tissues><United States National Institutes of Health><Vaccine Design><Vaccines><Viral><Viral Latency><Viral reservoir><Virus><Virus Latency><Virus Replication><Virus reservoir><Virus-HIV><Work><adoptive T cell transfer><adoptive T-cell therapy><antiretroviral therapy><antiretroviral treatment><cell sorting><deep sequencing><design><designing><drug resistant><drug/agent><economic implication><gastrointestinal><genome mutation><human immunodeficiency virus vaccine><humanized mice><humanized mouse><in vivo><innovate><innovation><innovative><killer T cell><latent HIV reservoir><latent HIV-1 reservoir><latent HIV1 reservoir><mouse model><murine model><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutics><novel therapy><peripheral blood><post-doc><post-doctoral><post-doctoral trainee><prevent><preventing><protein structure><protein structures><proteins structure><rational design><research associates><resistance mutation><resistance to Drug><resistant mutation><resistant to Drug><response><theories><therapeutic T-cell platform><therapeutic vaccine><therapeutically effective><treatment vaccines><vaccine for the treatment><vaccine for treatment><viral multiplication><viral rebound><viral replication><virus multiplication><virus rebound>
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Julia Louise Malik Dunn

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Good lead · 46/100
Likely hiring
Solid budget
Active award
$468,000
FY 2025

Project Title

Spatial and Temporal Resolution of EosinophilSpecialization in Allergic Microenvironments

Grant Number:

5DP2AI184728-02

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/12/2024

End Date:

7/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT Eosinophilic inflammation is a key feature of many human pathologies, and therapeutic targeting of eosinophils is of clinical interest, as illustrated by the new class of eosinophil-depleting drugs in development for allergic and inflammatory diseases. The full potential and consequences of...

Research Terms

<3-D><3-Dimensional><3D><Ablation><Acceleration><Address><Adopted><Affect><Agreement><Allergic><Allergic Disease><Allergic inflammation><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Apoptosis><Apoptosis Pathway><Area><Attenuated><Autoimmune><Autoimmune Diseases><Autoregulation><Award><Benign><Biology><Biopsy><Blood Eosinophil><Blood granulocytic cell><Blood leukocyte><Body Tissues><Cancers><Cell Body><Cell Communication and Signaling><Cell Cycle><Cell Cycle Proteins><Cell Division Cycle><Cell Division Cycle Proteins><Cell Signaling><Cell division><Cell-Cycle Regulatory Proteins><Cells><Chromatin><Chromatin Loop><Chromatin Loop Domains><Circulation><Clinical><Clinical Immunology><Co-culture><Cocultivation><Coculture><Coculture Techniques><Creativeness><Cyclin Gene><Cyclin-Dependent Kinases><Cyclin-Dependent Protein Kinases><Cyclins><DNA Loop><Development><Diagnosis><Disease><Disorder><Drugs><Effector Cell><Enabling Factors><Environment><Eosinophilia><Eosinophilic Esophagitis><Eosinophilic Granulocyte><Eosinophilic Leukocyte><Epithelial Cells><Epithelium><Event><Fibroblasts><Fibrosis><Gene Expression><Gene Transcription><Genetic><Genetic Transcription><Genome><Granular Leukocytes><Granulocytic cell><Health><Homeostasis><Human><Human Pathology><Immunoassay><In Vitro><Inflammation><Inflammatory><Injury><Intracellular Communication and Signaling><Leukocytes><Leukocytes Reticuloendothelial System><Lineage Tracing><M Phase><Maintenance><Malignant Neoplasms><Malignant Tumor><Marrow Eosinophil><Marrow leukocyte><Medical Research><Medication><Medicine><Metabolic><Mitosis><Mitosis Stage><Modern Man><Molecular><Mucosa><Mucosal Tissue><Mucous Membrane><NGS Method><NGS system><NIAID><National Institute of Allergy and Infectious Disease><Nuclear Structure><Parasites><Pathogenicity><Pathology><Pathway interactions><Patients><Pharmaceutical Preparations><Phase><Phenotype><Physiological Homeostasis><Position><Positioning Attribute><Prevalence><Problem Solving><Process><Productivity><Programmed Cell Death><Proteins><Publishing><RNA Expression><Regulation><Reporting><Research><Research Resources><Resolution><Resources><Role><Signal Transduction><Signal Transduction Systems><Signaling><Small Intestines><Structure><System><Technology><Testing><Time><Tissue Model><Tissues><Transcription><Translations><White Blood Cells><White Cell><Work><alleviate symptom><ameliorating symptom><attenuate><attenuates><autoimmune condition><autoimmune disorder><autoimmunity disease><biological signal transduction><cdc Proteins><cdk Proteins><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cellular lineage mapping><cellular lineage tracking><chronic inflammatory disease><clinical relevance><clinically relevant><creativity><cytokine><cytotoxic><decrease symptom><design><designing><developmental><differential expression><differentially expressed><disease natural history><drug/agent><druggable target><eosinophil><eosinophilic inflammation><experience><fewer symptoms><gene function><global gene expression><global transcription profile><granulocyte><improved><in vivo><inflammatory environment><inflammatory milieu><injuries><innovate><innovation><innovative><interest><life span><lifespan><malignancy><mouse model><murine model><neoplasm/cancer><new technology><next gen sequencing><next generation sequencing><nextgen sequencing><novel technologies><pathway><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><pharmacologic><postmitotic><posttranscriptional><prevent><preventing><reduce symptoms><relieves symptoms><resolutions><response><skills><small bowel><social role><spatial and temporal><spatial temporal><spatiotemporal><success><symptom alleviation><symptom reduction><symptom relief><temporal measurement><temporal resolution><therapeutic target><three dimensional><time measurement><transcriptional differences><transcriptome><translation><white blood cell><white blood corpuscle>
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Nir Drayman

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Good lead · 46/100
Likely hiring
Solid budget
Active award
$460,359
FY 2025

Project Title

Harnessing cell-to-cell variability to understand viral infection outcomes

Grant Number:

5DP2AI154437-04

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/18/2022

End Date:

7/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY / ABSTRACT This is a DP2 NIAID New Innovators Award proposal to harness cell-to-cell variability to understand viral infection outcomes at the single cell level. Infected cells differ in the outcome of infection (abortive/productive), the timing and level of viral gene expression and...

Research Terms

<(TNF)-α><Affect><Anti-viral Response><Anti-viral Therapy><Award><Basal Transcription Factor><Basal transcription factor genes><Biologic Models><Biological Models><Biology><Cachectin><Cell Body><Cell Fraction><Cells><Cellular biology><Collaborations><Custom><Data><Development><Gametes><Gene Expression><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genetic Transcription><Germ Cells><Germ-Line Cells><Goals><HSV-1><HSV1><Herpes Simplex Type 1><Herpes Simplex Virus 1><Herpes Simplex Virus Type 1><Herpesvirus 1><Host Factor><Host Factor Protein><Immunoglobulin Enhancer-Binding Protein><Infection><Infection Control><Integration Host Factors><Investigators><Investments><Life Cycle><Life Cycle Stages><Literature><Machine Learning><Macrophage-Derived TNF><Measurement><Methodology><Microfluidic Device><Microfluidic Lab-On-A-Chip><Microfluidic Microchips><Microfluidics><Modality><Model System><Modeling><Molecular><Monocyte-Derived TNF><NF-kB><NF-kappa B><NF-kappaB><NFKB><NIAID><National Institute of Allergy and Infectious Disease><Nuclear Factor kappa B><Nuclear Transcription Factor NF-kB><Outcome><Pathway interactions><Ph D student><Ph D. student><Ph. D. student><Ph.D student><Ph.D. student><PhD student><PhD. student><Phenotype><Position><Positioning Attribute><Probability><Process><Production><Productivity><RNA Expression><Reproductive Cells><Research><Research Personnel><Research Resources><Researchers><Resources><Science><Sex Cell><Shapes><Supervision><System><Systems Biology><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Technology><Testing><Therapeutic><Time><Titrations><Transcription><Transcription Factor NF-kB><Transcription Factor Proto-Oncogene><Transcription factor genes><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Validation><Viral><Viral Diseases><Viral Genes><Viral Genetics><Virus><Virus Diseases><Virus Replication><Work><cell biology><cell imaging><cellular imaging><continuous monitoring><customs><design><designing><developmental><doctoral student><herpes simplex i><herpes simplex-1><high reward><high risk><improved><initial cell><innovate><innovation><innovative><insight><kappa B Enhancer Binding Protein><life course><live cell image><live cell imaging><live cellular image><live cellular imaging><machine based learning><machine learned algorithm><machine learning algorithm><machine learning based algorithm><microfluidic chip><new approaches><novel><novel approaches><novel strategies><novel strategy><nuclear factor kappa beta><pathogen><pathogenic virus><pathway><programs><rational design><scRNA sequencing><scRNA-seq><secondary infection><sexual cell><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><tool><transcription factor><validations><viral infection><viral infectious disease treatment><viral multiplication><viral pathogen><viral replication><virology><virus genetics><virus host interaction><virus infection><virus multiplication><virus pathogen><virus-induced disease><µfluidic>
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BRENT E PALMER

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 44/100
Likely hiring
Above-average budget
$602,292
FY 2022

Project Title

Role of Chemokines in Innate and Adaptive Immunity in the Lung

Grant Number:

5R01HL152756-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2020

End Date:

3/31/2024

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Chronic beryllium disease (CBD) results from beryllium (Be) exposure in the workplace and is characterized by granulomatous inflammation and the accumulation of Be-specific, Th1-type cytokine-secreting CD4+ T cells in the lung. Be exposure is also associated with the induction of cyt...

Research Terms

<ACT2><AT744.1><Act-2><Adrenal Cortex Hormones><Antigen-Presenting Cells><Antigenic Determinants><Antigens><Beryllium><Beryllium granuloma><Binding><Binding Determinants><Bronchioalveolar Lavage><Bronchoalveolar Lavage><Bronchopulmonary Lavage><CAR T cells><CAR modified T cells><CCL3><CCL3 gene><CCL4><CCL4 gene><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cell Body><Cells><Chemokine (C-C Motif) Ligand 4><Chemokine (C-C motif) Ligand 3><Chemokine, CC Motif, Ligand 4><Chemotactic Cytokines><Chronic berylliosis><Chronic beryllium disease><Chronic beryllium lung><Chronic beryllium lung disease><Chronic beryllium poisoning><Complex><Corticoids><Corticosteroids><Data><Dendritic cell activation><Disease><Disorder><Dysfunction><Early Intervention><Epitopes><Functional disorder><G0S19-1><Gamma interferon><Generations><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Granuloma><Granulomatous><Granulomatous Lesion><Granulomatous disease><Granulomatous disorder><HLA-DP2><HLA-DPw2><HLA-DPw2 antigen><Homologous Chemotactic Cytokines><Human><IFN-Gamma><IFN-g><IFN-γ><IFNG><IFNγ><Immune><Immune Activation 2><Immune Cell Activation><Immune Interferon><Immune response><Immunes><Immunological response><In Vitro><Inflammation><Inflammatory><Innate Immunity><Intercrines><Interferon Gamma><Interferon Type II><Interferon-gamma><Job Location><Job Place><Job Setting><Job Site><LD78ALPHA><Lead><Ligands><Lung><Lung Inflammation><Lung Lavage><Lung Respiratory System><Lung damage><MIP 1alpha><MIP-1-alpha><MIP-1a><MIP1A><MIP1B><MIP1B1><Macrophage Inflammatory Protein 1-Beta><Mediating><Mediator><Mediator of Activation><Mediator of activation protein><Mice><Mice Mammals><Modern Man><Molecular Interaction><Murine><Mus><Native Immunity><Natural Immunity><Non-Specific Immunity><Nonspecific Immunity><Oxides><Pathogenicity><Pathology><Patients><Pb element><Peptides><Phenotype><Physiopathology><Pneumonitis><Process><Pulmonary Inflammation><Recombinant DNA Technology><Research Specimen><Rest><Role><SCYA3><SCYA4><SIS cytokines><Small Inducible Cytokine A3><Small Inducible Cytokine A4><Source><Specimen><Staining method><Stains><Stem Cell Inhibitor><T cell response><T cells for CAR><T-Cell Epitopes><T-Cells><T-Lymphocyte><T-Lymphocyte Epitopes><T4 Cells><T4 Lymphocytes><Therapeutic><Work Location><Work Place><Work-Site><Workplace><Worksite><accessory cell><adaptive immune response><adaptive immunity><bronchopulmonary lavage therapy><chemoattractant cytokine><chemokine><chimeric antigen receptor (CAR) T cells><chimeric antigen receptor T cells><chimeric antigen receptor modified T cells><cytokine><draining lymph node><engineered T cells><genetically engineered><heavy metal Pb><heavy metal lead><host response><immune activation><immune system response><immunogen><immunoresponse><in vivo><innovative technologies><lFN-Gamma><lung function><lung injury><migration><mouse model><murine model><neo-antigen><neo-epitopes><neoantigens><neoepitopes><new drug treatments><new drugs><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><next generation therapeutics><novel><novel drug treatments><novel drugs><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><pathophysiology><pulmonary><pulmonary damage><pulmonary function><pulmonary injury><pulmonary tissue damage><pulmonary tissue injury><recruit><regional lymph node><response><social role><thymus derived lymphocyte><translational study><work setting>
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Andrew P. Fontenot

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 44/100
Likely hiring
Above-average budget
$602,292
FY 2021

Project Title

Role of Chemokines in Innate and Adaptive Immunity in the Lung

Grant Number:

5R01HL152756-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2020

End Date:

3/31/2024

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Chronic beryllium disease (CBD) results from beryllium (Be) exposure in the workplace and is characterized by granulomatous inflammation and the accumulation of Be-specific, Th1-type cytokine-secreting CD4+ T cells in the lung. Be exposure is also associated with the induction of cyt...

Research Terms

<ACT2><AT744.1><Act-2><Adrenal Cortex Hormones><Antigen-Presenting Cells><Antigenic Determinants><Antigens><Beryllium><Beryllium granuloma><Binding><Binding Determinants><Bronchioalveolar Lavage><Bronchoalveolar Lavage><Bronchopulmonary Lavage><CAR T cells><CCL3><CCL3 gene><CCL4><CCL4 gene><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cell Body><Cells><Chemokine (C-C Motif) Ligand 4><Chemokine (C-C motif) Ligand 3><Chemokine, CC Motif, Ligand 4><Chemotactic Cytokines><Chronic berylliosis><Chronic beryllium disease><Chronic beryllium lung><Chronic beryllium lung disease><Chronic beryllium poisoning><Complex><Corticoids><Corticosteroids><Data><Dendritic cell activation><Disease><Disorder><Dysfunction><Early Intervention><Epitopes><Functional disorder><G0S19-1><Gamma interferon><Generations><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Granuloma><Granulomatous><Granulomatous Lesion><HLA-DP2><HLA-DPw2><HLA-DPw2 antigen><Homologous Chemotactic Cytokines><Human><IFN-Gamma><IFN-g><IFN-γ><IFNG><IFNγ><Immune><Immune Activation 2><Immune Cell Activation><Immune Interferon><Immune response><Immunes><Immunological response><In Vitro><Inflammation><Inflammatory><Innate Immunity><Intercrines><Interferon Gamma><Interferon Type II><Interferon-gamma><Job Location><Job Place><Job Setting><Job Site><LD78ALPHA><Lead><Ligands><Lung><Lung Inflammation><Lung Lavage><Lung Respiratory System><Lung damage><MIP 1alpha><MIP-1-alpha><MIP-1a><MIP1A><MIP1B><MIP1B1><Macrophage Inflammatory Protein 1-Beta><Mediating><Mediator><Mediator of Activation><Mediator of activation protein><Mice><Mice Mammals><Modern Man><Molecular Interaction><Murine><Mus><Native Immunity><Natural Immunity><Non-Specific Immunity><Nonspecific Immunity><Oxides><Pathogenicity><Pathology><Patients><Pb element><Peptides><Phenotype><Physiopathology><Process><Recombinant DNA Technology><Research Specimen><Rest><Role><SCYA3><SCYA4><SIS cytokines><Small Inducible Cytokine A3><Small Inducible Cytokine A4><Source><Specimen><Staining method><Stains><Stem Cell Inhibitor><T cell response><T cells for CAR><T-Cell Epitopes><T-Cells><T-Lymphocyte><T-Lymphocyte Epitopes><T4 Cells><T4 Lymphocytes><Therapeutic><Work Location><Work Place><Work-Site><Workplace><Worksite><accessory cell><adaptive immune response><adaptive immunity><bronchopulmonary lavage therapy><chemoattractant cytokine><chemokine><chimeric antigen receptor (CAR) T cells><chimeric antigen receptor T cells><cytokine><draining lymph node><engineered T cells><genetically engineered><heavy metal Pb><heavy metal lead><host response><immune activation><immune system response><immunogen><immunoresponse><in vivo><innovative technologies><lFN-Gamma><lung function><lung injury><migration><mouse model><murine model><neo-antigen><neo-epitopes><neoantigens><neoepitopes><new drug treatments><new drugs><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><next generation therapeutics><novel><novel drug treatments><novel drugs><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><pathophysiology><pulmonary><pulmonary function><recruit><regional lymph node><response><social role><thymus derived lymphocyte><translational study><work setting>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Shaikh M Atif

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 44/100
Likely hiring
Above-average budget
$595,002
FY 2023

Project Title

Role of Chemokines in Innate and Adaptive Immunity in the Lung

Grant Number:

5R01HL152756-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2020

End Date:

3/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Chronic beryllium disease (CBD) results from beryllium (Be) exposure in the workplace and is characterized by granulomatous inflammation and the accumulation of Be-specific, Th1-type cytokine-secreting CD4+ T cells in the lung. Be exposure is also associated with the induction of cyt...

Research Terms

<ACT2><AT744.1><Act-2><Adrenal Cortex Hormones><Antigen-Presenting Cells><Antigenic Determinants><Antigens><Beryllium><Beryllium granuloma><Binding><Binding Determinants><Bronchioalveolar Lavage><Bronchoalveolar Lavage><Bronchopulmonary Lavage><CAR T cells><CAR modified T cells><CAR-T><CAR-Ts><CCL3><CCL3 gene><CCL4><CCL4 gene><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cell Body><Cells><Chemokine (C-C Motif) Ligand 4><Chemokine (C-C motif) Ligand 3><Chemokine, CC Motif, Ligand 4><Chemotactic Cytokines><Chronic berylliosis><Chronic beryllium disease><Chronic beryllium lung><Chronic beryllium lung disease><Chronic beryllium poisoning><Complex><Corticoids><Corticosteroids><Data><Dendritic cell activation><Disease><Disorder><Dysfunction><Early Intervention><Epitopes><Functional disorder><G0S19-1><Generations><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Granuloma><Granulomatous><Granulomatous Lesion><Granulomatous disease><Granulomatous disorder><HLA-DP2><HLA-DPw2><HLA-DPw2 antigen><Homologous Chemotactic Cytokines><Human><IFN-Gamma><IFN-g><IFN-γ><IFNG><IFNγ><Immune><Immune Activation 2><Immune Cell Activation><Immune Interferon><Immune response><Immunes><Immunological response><In Vitro><Inflammation><Inflammatory><Innate Immunity><Intercrines><Interferon Gamma><Interferon Type II><Job Location><Job Place><Job Setting><Job Site><LD78ALPHA><Ligands><Lung><Lung Inflammation><Lung Lavage><Lung Respiratory System><Lung damage><MIP 1alpha><MIP-1-alpha><MIP-1a><MIP1A><MIP1B><MIP1B1><Macrophage Inflammatory Protein 1-Beta><Mediating><Mediator><Mice><Mice Mammals><Modern Man><Molecular Interaction><Murine><Mus><Native Immunity><Natural Immunity><Non-Specific Immunity><Nonspecific Immunity><Oxides><Pathogenicity><Pathology><Patients><Peptides><Phenotype><Physiopathology><Pneumonitis><Process><Pulmonary Inflammation><Recombinant DNA Technology><Research Specimen><Rest><Role><SCYA3><SCYA4><SIS cytokines><Small Inducible Cytokine A3><Small Inducible Cytokine A4><Source><Specimen><Staining method><Stains><Stem Cell Inhibitor><T cell response><T cells for CAR><T-Cell Epitopes><T-Cells><T-Lymphocyte><T-Lymphocyte Epitopes><T4 Cells><T4 Lymphocytes><Therapeutic><Work Location><Work Place><Work-Site><Workplace><Worksite><accessory cell><adaptive immune response><adaptive immunity><bronchopulmonary lavage therapy><chemoattractant cytokine><chemokine><chimeric antigen receptor (CAR) T cells><chimeric antigen receptor T cells><chimeric antigen receptor fusion protein T-cells><chimeric antigen receptor modified T cells><cytokine><draining lymph node><engineered T cells><genetically engineered><host response><immune activation><immune system response><immunogen><immunoresponse><in vivo><innovative technologies><lFN-Gamma><lung function><lung injury><migration><mouse model><murine model><neo-antigen><neo-epitopes><neoantigens><neoepitopes><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><pathophysiology><pulmonary><pulmonary damage><pulmonary function><pulmonary injury><pulmonary tissue damage><pulmonary tissue injury><recruit><regional lymph node><response><social role><thymus derived lymphocyte><translational study><work setting>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Neal L Weintraub

AUGUSTA UNIVERSITY, AUGUSTA, GA

Exploratory lead · 44/100
Likely hiring
Above-average budget
$527,553
FY 2021

Project Title

Mechanisms of myeloperoxidase and Nox4 interactions in abdominal aortic aneurysm

Grant Number:

5R01HL142097-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2018

End Date:

10/31/2022

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Abdominal aortic aneurysm (AAA) disease is a frequent cause of morbidity and mortality. Roughly 25,000 AAA repairs are performed each year, and AAAs account for over 13,000 deaths annually in the United States. The underlying mechanisms of AAA formation are unknown, which has hampere...

Research Terms

<3-Pyridinecarboxylic Acid><Abdominal Aortic Aneurysm><Address><Agonist><Alleles><Allelomorphs><Aneurysm><AngII><Angiotensin II><Animal Model><Animal Models and Related Studies><Aorta><Aortic Aneurysm><Assay><Bioassay><Biologic Assays><Biological Assay><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Blood Vessels><Blood leukocyte><Blood monocyte><Body Tissues><Calcium Chloride><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell Surface Receptors><Cells><Cessation of life><Coupled><D2 receptor><DRD2 Receptor><Data><Death><Deterioration><Development><Disease><Disorder><Dopamine D2 Receptor><Drug Targeting><Drugs><Enzyme Gene><Enzymes><Genetic><H2O2><Hematopoietic><Hemi-Myeloperoxidase><Heterozygote><Human><Hydrogen Peroxide><Hydroperoxide><In Vitro><Inflammation><Inflammatory><Infusion><Infusion procedures><Intracellular Communication and Signaling><KO mice><Knock-out Mice><Knockout Mice><Knowledge><Leiomyocyte><Leukocytes><Leukocytes Reticuloendothelial System><Link><Lipids><Lung><Lung Respiratory System><Marrow Neutrophil><Marrow leukocyte><Marrow monocyte><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediating><Medical><Medication><Mice><Mice Mammals><Modern Man><Morbidity><Morbidity - disease rate><Murine><Mus><Myeloperoxidase><Mφ><Neutrophil Activation><Neutrophil Infiltration><Neutrophil Recruitment><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Niacin><Nicotinic Acids><Null Mouse><Output><Oxidants><Oxidative Stress><Oxidizing Agents><PGD2><Pathogenesis><Patients><Peroxidases><Pharmaceutic Preparations><Pharmaceutical Preparations><Pharmacology><Play><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Prostaglandin D2><Proteins><Receptor Cell><Receptor Protein><Risk Factors><Role><Rupture><Ruptured Aortic Aneurysms><Signal Transduction><Signal Transduction Systems><Signaling><Site><Smoking><Smooth Muscle Cells><Smooth Muscle Myocytes><Smooth Muscle Tissue Cell><Source><Structure><Testing><Therapeutic><Tissues><United States><White Blood Cells><White Cell><aorta aneurysm><biological signal transduction><developmental><drug/agent><electron acceptor><experiment><experimental research><experimental study><hemopoietic><heterozygosity><improved outcome><in vivo><inhibitor><inhibitor/antagonist><macrophage><model of animal><model organism><monocyte><mortality><neutrophil><novel><overexpress><overexpression><prevent><preventing><pulmonary><receptor><recruit><repair><repaired><social role><therapeutic outcome><therapeutically effective><therapy outcome><uptake><vascular><white blood cell><white blood corpuscle>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Daniel Gallego-Perez

OHIO STATE UNIVERSITY, Columbus, OH

Exploratory lead · 36/100
Likely hiring
Solid budget
$372,825
FY 2022

Project Title

Novel nanoscale approaches to whole tissue reprogramming

Grant Number:

3DP2EB028110-01S1

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/4/2022

End Date:

8/31/2023

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT: This application focuses on the development of novel vasculogenic cell therapies to treat cerebral blood flow (CBF) deficits in Alzheimer’s disease (AD). The goal is to improve CBF in AD by pre-programming fibroblasts to convert into induced endothelial cells (iECs) to drive the formation ...

Research Terms

<AD dementia><AD model><AD related dementia><ADRD><Address><Affect><Alzheimer><Alzheimer Type Dementia><Alzheimer disease><Alzheimer related dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease dementia><Alzheimer's disease model><Alzheimer's disease related dementia><Alzheimer's disease therapy><Alzheimer's therapy><Alzheimers Dementia><Alzheimers disease><Amentia><Amyloid Plaques><Apoplexy><Award><Basal Transcription Factor><Basal transcription factor genes><Behavioral><Blood Vessels><Body Tissues><Brain Stem><Brain Vascular Accident><Brainstem><Cell Body><Cell Therapy><Cells><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Circulation><Cerebrovascular Stroke><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive deficits><Cognitive function abnormal><Data><Dementia><Development><Disturbance in cognition><EWSR2><Endothelial Cells><Ewing Sarcoma Breakpoint Region 2><FLI1><FLI1 gene><FOXC2><FOXC2 gene><Face><Fibroblasts><Fli-1 proto-oncogene, ETS transcription factor><Friend leukemia virus integration 1><Future><General Transcription Factor Gene><General Transcription Factors><Goals><Impaired cognition><Impairment><Ischemic Stroke><Lead><Link><Mice><Mice Mammals><Murine><Mus><Neuritic Plaques><Neurofibrillary Tangles><Nuclear><Outcome Study><Pathology><Patients><Pb element><Perfusion><Persons><Pharmacology><Pilot Projects><Play><Prevention><Primary Senile Degenerative Dementia><Reporting><Research><Running><SIC-1><Safety><Senile Plaques><Stroke><Therapeutic><Time><Tissues><Transcription Factor Proto-Oncogene><Transcription factor genes><Work><alzheimer model><amyloid assembly><amyloid beta plaque><amyloid formation><amyloid-b plaque><aβ plaques><base><brain attack><brain blood flow><burden of disease><burden of illness><cell mediated therapies><cell-based therapeutic><cell-based therapy><cellular therapy><cerebral blood flow><cerebral circulation><cerebral vascular accident><cerebrocirculation><cerebrovascular accident><cerebrovascular blood flow><cognitive defects><cognitive dysfunction><cognitive loss><cored plaque><dementia of the Alzheimer type><developmental><diffuse plaque><disease burden><extracellular vesicles><faces><facial><heavy metal Pb><heavy metal lead><improved><in vivo><innovate><innovation><innovative><manage symptom><motor impairment><mouse model><movement impairment><movement limitation><murine model><nano meter scale><nano meter sized><nano scale><nanometer scale><nanometer sized><nanoscale><nanotransfection><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><novel><p-tau><p-τ><phospho-tau><phospho-τ><phosphorylated tau><pilot study><prevent><preventing><primary degenerative dementia><response><senile dementia of the Alzheimer type><stroke recovery><symptom management><tangle><tau-1><transcription factor><vascular><years of life lost to disability><years of life lost to disease>
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Yongxin Zhao

CARNEGIE-MELLON UNIVERSITY, PITTSBURGH, PA

Exploratory lead · 36/100
Likely hiring
Solid budget
$356,860
FY 2022

Project Title

THE SYNAPTIC TYPE LANDSCAPE OF ALZHEIMER'S DISEASE VISUALIZED BY MULTIPLEX EXPANSION SYNAPTIC NANOSCOPY

Grant Number:

3DP2EB028111-01S1

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2018

End Date:

8/31/2023

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

THE SYNAPTIC TYPE LANDSCAPE OF ALZHEIMER'S DISEASE VISUALIZED BY MULTIPLEX EXPANSION SYNAPTIC NANOSCOPY Abstract Alzheimer's disease (AD) is the most prevalent neurodegenerative disorder, with high morbidity and mortality and high costs toward patient care and management, posing a major global publi...

Research Terms

<21+ years old><3-D><3-Dimensional><3D><AD dementia><AD model><Adult><Adult Human><Affect><Age><Age-Months><Alzheimer><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's brain><Alzheimer's disease brain><Alzheimer's disease dementia><Alzheimer's disease model><Alzheimer's disease risk><Alzheimers Dementia><Alzheimers disease><Ammon Horn><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Antibodies><Area><Assay><Aβ><Behavioral Symptoms><Bioassay><Biochemical><Biologic Assays><Biological Assay><Body Tissues><Brain><Brain Nervous System><Brain region><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 public health crisis><COVID19 crisis><COVID19 epidemic><COVID19 global health crisis><COVID19 global pandemic><COVID19 health crisis><COVID19 pandemic><COVID19 public health crisis><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Clinical><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Cornu Ammonis><Data><Degenerative Neurologic Diseases><Degenerative Neurologic Disorders><Dentate Fascia><Development><Diathesis><Disease><Disease susceptibility><Disorder><Disturbance in cognition><Dysfunction><EOAD><Early Onset Alzheimer Disease><Encephalon><Fascia Dentata><Fostering><Functional disorder><GWA study><GWAS><Gene Proteins><Generations><Genetic><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Glia><Glial Cells><Goals><Gyrus Dentatus><Hippocampus><Hippocampus (Brain)><Human><Image><Immunomodulation><Impaired cognition><In Situ><Individual><Inflammation><Inherited Predisposition><Inherited Susceptibility><Intracellular Communication and Signaling><Kolliker's reticulum><Laboratories><Light><Link><Location><Memory Loss><Mice><Mice Mammals><Modern Man><Modification><Molecular><Morbidity><Morbidity - disease rate><Murine><Mus><Nanoscopy><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neuritic Plaques><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neuroglia><Neuroglial Cells><Neurologic Degenerative Conditions><Neuron Degeneration><Neurons><Non-neuronal cell><Nonneuronal cell><Outcome><Parents><Pathologic><Pathology><Pathway interactions><Patient Care Management><Pattern><Phenotype><Photoradiation><Physiopathology><Polymers><Population><Primary Senile Degenerative Dementia><Property><Protein Gene Products><Proteins><Proteome><Proteomics><Public Health><Reagent><Research Resources><Research Specimen><Resolution><Resources><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-CoV2 epidemic><SARS-CoV2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Sampling><Senile Plaques><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Signal Transduction><Signal Transduction Systems><Signaling><Site><Specimen><Synapses><Synaptic><Tissues><Transgenic Mice><Work><a beta peptide><abeta><abeta accumulation><abeta aggregation><adulthood><ages><alzheimer model><alzheimer risk><amyloid beta><amyloid beta accumulation><amyloid beta aggregation><amyloid beta plaque><amyloid β accumulation><amyloid β aggregation><amyloid-b plaque><amyloid-b protein><amyloidogenesis><anti-microbial><antimicrobial><aβ accumulation><aβ aggregation><aβ plaques><beta amyloid fibril><biological signal transduction><brain amyloidogenesis><brain tissue><cell type><cognitive dysfunction><cognitive loss><cored plaque><corona virus disease 2019 epidemic><corona virus disease 2019 pandemic><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><cost><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><dementia of the Alzheimer type><dentate gyrus><developmental><diffuse plaque><early onset AD><early onset Alzheimer's><excitatory neuron><fluorescence imaging><fluorescent imaging><genetic etiology><genetic mechanism of disease><genetic vulnerability><genetically predisposed><genome wide association><genome wide association scan><genome wide association studies><genome wide association study><genomewide association scan><genomewide association studies><genomewide association study><high dimensionality><hippocampal><image processing><image-based method><imaging><imaging method><imaging modality><imaging platform><immune modulation><immune regulation><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><innovate><innovation><innovative><liability to disease><machine learning based method><machine learning method><machine learning methodologies><memory decline><molecular imaging><molecule imaging><mortality><mouse model><murine model><nano meter scale><nano meter sized><nano scale><nanometer scale><nanometer sized><nanoscale><nerve cement><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neuroinflammation><neuroinflammatory><neurological degeneration><neuronal><neuronal degeneration><neuropathology><new drug treatments><new drugs><new therapeutics><new therapy><next generation therapeutics><non-demented><nondemented><novel drug treatments><novel drugs><novel therapeutics><novel therapy><overexpress><overexpression><pathophysiology><pathway><preservation><primary degenerative dementia><protein protein interaction><senile dementia of the Alzheimer type><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><soluble amyloid precursor protein><statistical and machine learning><synapse><three dimensional><tool><unsupervised learning><unsupervised machine learning><vector><whole genome association analysis><whole genome association studies><whole genome association study>
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Jacqueline Linnes

PURDUE UNIVERSITY, WEST LAFAYETTE, IN

Exploratory lead · 36/100
Likely hiring
Solid budget
$289,274
FY 2023

Project Title

Pont-of-use Acute HIV Infection Diagnostic for Substance Using Populations

Grant Number:

3DP2DA051910-01S1

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2020

End Date:

6/30/2025

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Parent Grant: 1DP2DA051910 Parent Grant Title: Point-of-use Acute HIV Infection Diagnostic for Substance Using Populations Supplement Title: Expansion of Point-of-use Acute HIV Infection platform for Hepatitis C Virus An estimated 2.3 million individuals with HIV infection are co-infected with hepat...

Research Terms

<3' Untranslated Regions><3'UTR><AIDS Virus><AIDS test><AIDS/HIV test><Acceleration><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Acute><Acute Hepatitis><Acute Hepatitis C><Anti-HCV Antibodies><Anti-Hepatitis C Virus Antibodies><Antibodies><Assay><Attitude><Bioassay><Biologic Assays><Biological Assay><Blood><Blood Plasma><Blood Reticuloendothelial System><Blood Sample><Blood capillaries><Blood specimen><Buffers><Cessation of life><Chronic Hepatitis C><Chronic type C viral hepatitis><Chronic viral hepatitis C><Clinic><Clinical><Cold Chains><Continuity of Care><Continuity of Patient Care><Continuum of Care><Cytolysis><Death><Detection><Development><Devices><Diagnosis><Diagnostic><Diagnostic tests><Drops><Drug user><Drugs><Dryness><Elements><Exposure to><Feedback><Functional RNA><Genome><Goals><HCV><HCV Antibodies><HCV Transmission><HCV infection><HCV/HIV><HIV><HIV Infections><HIV and HCV><HIV and hepatitis C><HIV diagnosis><HIV test><HIV-1><HIV-1 test><HIV-2 test><HIV-HCV><HIV-I><HIV/HCV><HIV/Hepatitis C><HIV1><HTLV-III Infections><HTLV-III-LAV Infections><Healthcare><Heating><Hepatic Cirrhosis><Hepatic Disorder><Hepatitis C><Hepatitis C Antibodies><Hepatitis C Transmission><Hepatitis C Virus Antibodies><Hepatitis C virus><Hepatitis C virus infection><Hepatitis, Viral, Non-A, Non-B, Parenterally-Transmitted><Hepatitus C><Human><Human Immunodeficiency Virus Type 1><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Infections><Human immunodeficiency virus 1><Human immunodeficiency virus test><Individual><Infection><Infrastructure><Injections><Intervention><Intervention Strategies><Kentucky><LAV-HTLV-III><Laboratories><Liver Cirrhosis><Liver diseases><Lymphadenopathy-Associated Virus><Lysis><Marketing><Medication><Microfluidics><Modern Man><Needle-Exchange Programs><Non-Coding><Non-Coding RNA><Non-Polyadenylated RNA><Non-translated RNA><Noncoding RNA><Nontranslated RNA><Nucleic Acid Amplification Tests><Nucleic Acid Testing><PWUD><Paper><Pharmaceutic Preparations><Pharmaceutical Preparations><Pharmacies><Pharmacy facility><Plasma><Plasma Serum><Population><Preparation><Process><Proteins><Protocol><Protocols documentation><RNA><RNA Gene Products><RT-PCR><RTPCR><Rapid diagnostics><Reaction><Reagent><Resistance><Reticuloendothelial System, Serum, Plasma><Reverse Transcriptase Polymerase Chain Reaction><Ribonucleic Acid><Running><Rural><Rural Health><Sampling><Site><Syringe-Exchange Programs><Technology><Testing><Time><Transmission><Untranslated RNA><Viral><Viral Burden><Viral Load><Viral Load result><Virus><Virus-HIV><Visual><Waxes><Whole Blood><acceptability and feasibility><access to health care><access to healthcare><accessibility of health care><accessibility to health care><accessibility to healthcare><acute infection><anti-hepatitis C><antibody based detection><antibody detection><barrier to care><barrier to health care><barrier to healthcare><barrier to treatment><capillary><chronic HCV infection><chronic hepatitis C virus infection><clinical relevance><clinically relevant><community based participatory research><community led research><community participatory research><community research><design><designing><detect antibodies><detection limit><developmental><drug/agent><health care><health care access><health care availability><health care service access><health care service availability><healthcare access><healthcare accessibility><healthcare availability><healthcare service access><healthcare service availability><hep C><hepatic disease><hepatitis C virus transmission><hepatitis non A non B><hepatopathy><high risk><improved><infection by hepatitis c virus><interventional strategy><lateral flow assay><lateral flow test><liver disorder><needle exchange><new approaches><non A, non B hepatitis><non-A, non-B hepatitis><noncoding><novel><novel approaches><novel strategies><novel strategy><obstacle to care><obstacle to healthcare><parent grant><participatory action research><particle><people who use drugs><people who use illicit drugs><persons who use drugs><preparations><prevent><preventing><prototype><resistant><reverse transcriptase PCR><service providers><social cultural factor><social culture determinant><sociocultural determinant><sociocultural factor><substance abuse therapy><substance abuse treatment><substance use><substance using><syringe exchange><syringe exchange services><syringe service programs><systemic barrier><systemic hurdle><systemic obstacle><technology platform><technology system><transmission process><usability><viron><µfluidic>
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CHENG ZHANG

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 36/100
Likely hiring
Active award
$231,205
FY 2024

Project Title

Structure, pharmacology and signaling of G protein-coupled receptors (GPCRs) in inflammation

Grant Number:

3R35GM128641-06S1

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2018

End Date:

12/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Inflammation is a complex process with many lipid and peptide mediators involved. A large number of these mediators elicit either pro-inflammatory or pro-resolving effects through the action on G protein-coupled receptors (GPCRs). My lab is interested in the molecular mechanisms by w...

Research Terms

<ALXR><Address><Agonist><Biology><C5a Receptors><C5a anaphylatoxin receptor><CD88 Antigens><CHEMERINR><CHEMR23><CMKLR1><CMKLR1 gene><Cell Communication and Signaling><Cell Signaling><Cell membrane><Chemerin Receptor><Chemicals><Chemoattractant Receptor><Chemokine Like Receptor 1><Chemotactic Peptide Receptor><Complement 5a Receptor><Complex><Computational Biology><Cryo-electron Microscopy><Cryoelectron Microscopy><Cytoplasmic Membrane><D2 receptor><DRD2 Receptor><Development><Disease><Disorder><Dopamine D2 Receptor><Drug Controls><Drugs><Electron Cryomicroscopy><F-Chemotactic Peptide Receptor><FPR2><FPR2 gene><FPRH1><FPRL1><Family><Fatty Acids><Formyl Peptide Receptor 2><Formyl Peptide Receptor Homolog 1><Formyl Peptide Receptor-Like 1><Formyl Peptide Receptors><Funding><Future><G Protein-Complex Receptor><G Protein-Coupled Receptor 32><G Protein-Coupled Receptor Genes><G Protein-Coupled Receptor Signaling><G-Protein-Coupled Receptors><GPCR><GPCR Signaling><GPR32><GPR32 gene><GPR84><GPR84 gene><HM63><Immunology><Inflammation><Inflammatory><Inflammatory Response><Intracellular Communication and Signaling><LXA4R><Ligands><Lipids><Lipoxin A4 Receptor><Macrophage><Mediator><Medication><Medium chain fatty acid><Molecular><Molecular Configuration><Molecular Conformation><Molecular Stereochemistry><Mφ><N-Formylmethionyl Peptide Receptor><N-formyl Hexapeptide Receptor><New Agents><Omega-3 Fatty Acids><Omega-3 PUFA><Omega-3 Polyunsaturated Fatty Acid><Omega3><PGD2><Peptides><Phagocytosis><Pharmaceutical Preparations><Pharmacology><Plasma Membrane><Process><Property><Prostaglandin D2><Receptor Protein><Research><Resolution><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Structure><antagonism><antagonist><biological signal transduction><computer biology><conformation><conformational><conformational state><conformationally><conformations><cryo-EM><cryoEM><cryogenic electron microscopy><developmental><drug candidate><drug development><drug/agent><fMet-Leu-Phe receptor><interest><member><n-3 Fatty Acids><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><omega-3><pharmacologic><plasmalemma><receptor><receptor binding><receptor bound><receptor function><resolutions><small molecule><structural biology><targeted agent><tool><ω-3 fatty acids>
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Kiera L. Clayton

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

Exploratory lead · 36/100
Likely hiring
Active award
$104,091
FY 2024

Project Title

Characterizing Macrophages as "Hide-Outs" for Chronic Pathogens

Grant Number:

3DP2AI154438-04S1

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2021

End Date:

7/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY This proposal describes the framework of an NIAID New Innovators DP2 award for Kiera Clayton, PhD. Dr. Clayton is currently a postdoctoral fellow under the supervision of Dr. Bruce Walker at the Ragon Institute of MGH, MIT and Harvard, whose current research focuses on T cell and NK ...

Research Terms

<AIDS><AIDS Virus><Acquired Immune Deficiency><Acquired Immune Deficiency Syndrome><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome><Acquired Immunodeficiency Syndrome Virus><Address><Anti-Retroviral Agents><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Antigens><Apoptosis><Apoptosis Pathway><Area><Award><Body Tissues><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CD94 Antigen><CMV><Candidate Disease Gene><Candidate Gene><Cardiovascular Diseases><Caspase><Caspase Gene><Cell Body><Cell Communication><Cell Death><Cell Interaction><Cell-Death Protease><Cell-Mediated Lympholytic Cells><Cell-to-Cell Interaction><Cells><Cessation of life><Characteristics><Chronic><Cysteine Endopeptidases><Cysteine Protease><Cysteine Proteinases><Cytolytic T-Cell><Cytomegalovirus><Cytotoxic T Cell><Cytotoxic T-Lymphocytes><Cytotoxic cell><Data><Death><Development><Doctor of Philosophy><Drugs><Exhibits><Expression Signature><Failure><Future><Gene Expression Profile><Goals><Granzyme><HCMV><HIV><HIV Infections><HIV/Mtb><HIV/TB><HIV/mycobacterium tuberculosis><HIV/tuberculosis><HTLV-III Infections><HTLV-III-LAV Infections><Hepatic Disorder><Human><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Infections><ICE-like protease><Immune><Immune Evasion><Immune response><Immunes><Immunity><Immunological response><Immunology><Individual><Induction of Apoptosis><Infection><Inflammation><K lymphocyte><KLRD1 Protein><Killer Cell Lectin-Like Receptor Subfamily D, Member 1><Killer Cell Lectin-Like Receptor Subfamily D, Member 1 Isoforms 1, 2><Killer Cell Lectin-Like Receptor Subfamily D, Member 1 Protein><Knock-out><Knockout><Kp43 antigen><LAV-HTLV-III><Laboratories><Ligands><Liver diseases><Lymphadenopathy-Associated Virus><M tb><M tuberculosis><M tuberculosis infection><M. tb><M. tb infection><M. tuberculosis><M. tuberculosis infection><M. tuberculosis/HIV><M.tb infection><M.tuberculosis infection><MTB infection><Macrophage><Mediating><Medication><Methods><Miscellaneous Antibiotic><Mission><Modern Man><Mycobacterium tuberculosis><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><Mφ><NIAID><NK Cell Receptor><NK Cells><NK receptor><National Institute of Allergy and Infectious Disease><Natural Killer Cells><Natural Killer Cells Antigen CD94><Nature><Pathway interactions><Penetrance><Ph.D.><PhD><Pharmaceutical Preparations><Postdoc><Postdoctoral Fellow><Predisposition><Productivity><Programmed Cell Death><Proteins><Publishing><Research><Research Associate><Resistance><Salivary Gland Viruses><Supervision><Susceptibility><T cell response><T-Cells><T-Lymphocyte><T-Lymphocyte and NK-Cell><T-Lymphocyte and Natural Killer Cell><T4 Cells><T4 Lymphocytes><TB infection><Tissues><Tuberculosis><Viral><Virus><Virus-HIV><Work><anti-retroviral><antigen-specific T cells><antiretroviral therapy><antiretroviral treatment><cardiovascular disorder><cell killing><cell type><co-morbid><co-morbidity><comorbidity><cystein protease><cystein proteinase><cysteine endopeptidase><cytokine><cytomegalovirus group><cytotoxic CD8 T cells><cytotoxic CD8 T lymphocyte><design><designing><develop therapy><developmental><disseminated TB><disseminated tuberculosis><drug/agent><gene expression pattern><gene expression signature><hepatic disease><hepatopathy><host response><immune evasive><immune system response><immunogen><immunoresponse><infection due to Mycobacterium tuberculosis><inhibitor><innovate><innovation><innovative><insight><intervention design><intervention development><killer T cell><liver disorder><mtb><necrocytosis><neutralizing antibody><pathogen><pathway><post-doc><post-doctoral><post-doctoral trainee><prevent><preventing><programs><research associates><resistant><response><side effect><systemic inflammation><systemic inflammatory response><therapeutic agent development><therapeutic development><therapy design><therapy development><thymus derived lymphocyte><transcriptional profile><transcriptional signature><treatment design><treatment development><tuberculosis infection><tuberculous spondyloarthropathy><virological synapse><virology>
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Nir Drayman

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Exploratory lead · 36/100
Likely hiring
Active award
$82,768
FY 2024

Project Title

Harnessing cell-to-cell variability to understand viral infection outcomes

Grant Number:

3DP2AI154437-03S1

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/18/2022

End Date:

7/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY / ABSTRACT This is a DP2 NIAID New Innovators Award proposal to harness cell-to-cell variability to understand viral infection outcomes at the single cell level. Infected cells differ in the outcome of infection (abortive/productive), the timing and level of viral gene expression and...

Research Terms

<(TNF)-α><Affect><Anti-viral Response><Anti-viral Therapy><Award><Basal Transcription Factor><Basal transcription factor genes><Biologic Models><Biological Models><Biology><Cachectin><Cell Body><Cell Fraction><Cells><Cellular biology><Collaborations><Custom><Data><Development><Gametes><Gene Expression><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genetic Transcription><Germ Cells><Germ-Line Cells><Goals><HSV-1><HSV1><Herpes Simplex Type 1><Herpes Simplex Virus 1><Herpes Simplex Virus Type 1><Herpesvirus 1><Host Factor><Host Factor Protein><Immunoglobulin Enhancer-Binding Protein><Infection><Infection Control><Integration Host Factors><Investigators><Investments><Life Cycle><Life Cycle Stages><Literature><Machine Learning><Macrophage-Derived TNF><Measurement><Methodology><Microfluidic Device><Microfluidic Lab-On-A-Chip><Microfluidic Microchips><Microfluidics><Modality><Model System><Modeling><Molecular><Monitor><Monocyte-Derived TNF><NF-kB><NF-kappa B><NF-kappaB><NFKB><NIAID><National Institute of Allergy and Infectious Disease><Nuclear Factor kappa B><Nuclear Transcription Factor NF-kB><Outcome><Pathway interactions><Ph D student><Ph D. student><Ph. D. student><Ph.D student><Ph.D. student><PhD student><PhD. student><Phenotype><Position><Positioning Attribute><Probability><Process><Production><Productivity><RNA Expression><Reproductive Cells><Research><Research Personnel><Research Resources><Researchers><Resources><Science><Sex Cell><Shapes><Supervision><System><Systems Biology><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Technology><Testing><Therapeutic><Time><Titrations><Transcription><Transcription Factor NF-kB><Transcription Factor Proto-Oncogene><Transcription factor genes><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Validation><Viral><Viral Diseases><Viral Genes><Viral Genetics><Virus><Virus Diseases><Virus Replication><Work><cell biology><cell imaging><cellular imaging><customs><design><designing><developmental><doctoral student><herpes simplex i><herpes simplex-1><high reward><high risk><improved><initial cell><innovate><innovation><innovative><insight><kappa B Enhancer Binding Protein><life course><live cell image><live cell imaging><live cellular image><live cellular imaging><machine based learning><machine learned algorithm><machine learning algorithm><machine learning based algorithm><microfluidic chip><new approaches><novel><novel approaches><novel strategies><novel strategy><nuclear factor kappa beta><pathogen><pathogenic virus><pathway><programs><rational design><scRNA-seq><secondary infection><sexual cell><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><tool><transcription factor><validations><viral infection><viral infectious disease treatment><viral multiplication><viral pathogen><viral replication><virology><virus genetics><virus host interaction><virus infection><virus multiplication><virus pathogen><virus-induced disease><µfluidic>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Nir Drayman

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Exploratory lead · 36/100
Likely hiring
Active award
$41,384
FY 2024

Project Title

Harnessing cell-to-cell variability to understand viral infection outcomes

Grant Number:

3DP2AI154437-02S1

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/18/2022

End Date:

7/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY / ABSTRACT This is a DP2 NIAID New Innovators Award proposal to harness cell-to-cell variability to understand viral infection outcomes at the single cell level. Infected cells differ in the outcome of infection (abortive/productive), the timing and level of viral gene expression and...

Research Terms

<(TNF)-α><Affect><Anti-viral Response><Anti-viral Therapy><Award><Basal Transcription Factor><Basal transcription factor genes><Biologic Models><Biological Models><Biology><Cachectin><Cell Body><Cell Fraction><Cells><Cellular biology><Collaborations><Custom><Data><Development><Gametes><Gene Expression><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genetic Transcription><Germ Cells><Germ-Line Cells><Goals><HSV-1><HSV1><Herpes Simplex Type 1><Herpes Simplex Virus 1><Herpes Simplex Virus Type 1><Herpesvirus 1><Host Factor><Host Factor Protein><Immunoglobulin Enhancer-Binding Protein><Infection><Infection Control><Integration Host Factors><Investigators><Investments><Life Cycle><Life Cycle Stages><Literature><Machine Learning><Macrophage-Derived TNF><Measurement><Methodology><Microfluidic Device><Microfluidic Lab-On-A-Chip><Microfluidic Microchips><Microfluidics><Modality><Model System><Modeling><Molecular><Monitor><Monocyte-Derived TNF><NF-kB><NF-kappa B><NF-kappaB><NFKB><NIAID><National Institute of Allergy and Infectious Disease><Nuclear Factor kappa B><Nuclear Transcription Factor NF-kB><Outcome><Pathway interactions><Ph D student><Ph D. student><Ph. D. student><Ph.D student><Ph.D. student><PhD student><PhD. student><Phenotype><Position><Positioning Attribute><Probability><Process><Production><Productivity><RNA Expression><Reproductive Cells><Research><Research Personnel><Research Resources><Researchers><Resources><Science><Sex Cell><Shapes><Supervision><System><Systems Biology><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Technology><Testing><Therapeutic><Time><Titrations><Transcription><Transcription Factor NF-kB><Transcription Factor Proto-Oncogene><Transcription factor genes><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Validation><Viral><Viral Diseases><Viral Genes><Viral Genetics><Virus><Virus Diseases><Virus Replication><Work><cell biology><cell imaging><cellular imaging><customs><design><designing><developmental><doctoral student><herpes simplex i><herpes simplex-1><high reward><high risk><improved><initial cell><innovate><innovation><innovative><insight><kappa B Enhancer Binding Protein><life course><live cell image><live cell imaging><live cellular image><live cellular imaging><machine based learning><machine learned algorithm><machine learning algorithm><machine learning based algorithm><microfluidic chip><new approaches><novel><novel approaches><novel strategies><novel strategy><nuclear factor kappa beta><pathogen><pathogenic virus><pathway><programs><rational design><scRNA-seq><secondary infection><sexual cell><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><tool><transcription factor><validations><viral infection><viral infectious disease treatment><viral multiplication><viral pathogen><viral replication><virology><virus genetics><virus host interaction><virus infection><virus multiplication><virus pathogen><virus-induced disease><µfluidic>
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Gaurav Das Gaiha

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 26/100
Likely hiring
$180,545
FY 2023

Project Title

Exploiting Highly Networked CTL Epitopes to Achieve a Functional HIV Cure

Grant Number:

3DP2AI154421-03S1

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2020

End Date:

8/31/2025

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT The HIV/AIDS epidemic continues to have enormous medical, societal and economic implications worldwide. While combination anti-retroviral therapy (cART) has greatly reduced the global burden of HIV, the ability of the virus to establish a persistent reservoir within the body requires that H...

Research Terms

<AIDS Virus><AIDS/HIV><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Adoptive Transfer><Algorithms><Alleles><Allelomorphs><Anatomic Sites><Anatomic structures><Anatomy><Antigenic Determinants><Area><Binding Determinants><Blood><Blood Reticuloendothelial System><Body Tissues><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cell Body><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cell-Mediated Lympholytic Cells><Cells><Chronic><Clone Cells><Co-culture><Cocultivation><Coculture><Coculture Techniques><Collaborations><Core Facility><Cytolysis><Cytolytic T-Cell><Cytotoxic T Cell><Cytotoxic T-Lymphocytes><DNA><Data><Deoxyribonucleic Acid><Drug resistance><Drug toxicity><Drugs><Effectiveness><Epidemic><Epitopes><Fellowship><Genetic Alteration><Genetic Change><Genetic defect><Genetics-Mutagenesis><Goals><HIV><HIV vaccine><HIV/AIDS><HIV/AIDS Vaccines><Human Immunodeficiency Viruses><Impairment><Individual><Investigation><Investments><Knowledge><LAV-HTLV-III><Life><Link><Lymphadenopathy-Associated Virus><Lysis><Mediating><Medical><Medication><Methodology><Mission><Modality><Mutagenesis><Mutagenesis Molecular Biology><Mutate><Mutation><NIH><National Institutes of Health><Network Analysis><Pathway Analysis><Patients><Pharmaceutic Preparations><Pharmaceutical Preparations><Postdoc><Postdoctoral Fellow><Progressive Disease><Proteome><Public Health><Publishing><Research><Research Associate><Research Resources><Resources><Rest><Science><Site><Structure><T cell response><T-Cell Epitopes><T-Lymphocyte Epitopes><T4 Cells><T4 Lymphocytes><Therapeutic><Tissue Sample><Tissues><United States National Institutes of Health><Vaccine Design><Vaccines><Viral><Viral Latency><Viral reservoir><Virus><Virus Latency><Virus Replication><Virus reservoir><Virus-HIV><Work><anti-retroviral therapy><anti-retroviral treatment><antiretroviral therapy><antiretroviral treatment><cell sorting><deep sequencing><design><designing><drug resistant><drug/agent><economic implication><gastrointestinal><genome mutation><human immunodeficiency virus vaccine><humanized mice><humanized mouse><in vivo><innovate><innovation><innovative><killer T cell><latent HIV reservoir><latent HIV-1 reservoir><latent HIV1 reservoir><mouse model><murine model><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutics><novel therapy><peripheral blood><post-doc><post-doctoral><post-doctoral trainee><prevent><preventing><protein structure><protein structures><proteins structure><rational design><research associates><resistance mutation><resistance to Drug><resistant mutation><resistant to Drug><response><theories><therapeutic vaccine><therapeutically effective><treatment vaccines><vaccine for the treatment><vaccine for treatment><viral multiplication><viral rebound><viral replication><virus multiplication><virus rebound>
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Ross Okimoto

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 26/100
Training-friendly
Career award
$177,372
FY 2022

Project Title

Therapeutic rescue of the transcriptional repressor Capicua to inhibit lung cancer metastasis

Grant Number:

5K08CA222625-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2018

End Date:

1/31/2023

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary Abstract Candidate: Ross Okimoto, MD is a medical oncologist who believes that disease focused basic science research can improve outcomes for patients with cancer. Dr. Okimoto's long-term goal is to lead an independent laboratory-based translational research program aimed at identif...

Research Terms

<Achievement><Achievement Attainment><Award><Basic Research><Basic Science><Binding><California><Cancer Cause><Cancer Etiology><Cancer Genes><Cancer Patient><Cancer-Promoting Gene><Cancers><Cell Communication and Signaling><Cell Signaling><Cessation of life><Chest><Clinical><Clinical Trials><Co-Immunoprecipitations><Community Physician><Data><Death><Development><Disease><Disorder><Doctor of Philosophy><E1A Enhancer-Binding Protein E1AF><E1A enhancer binding protein><E1A enhancer-binding protein F><E1A-F><E1AF><ETV4><ETV4 gene><Ensure><Environment><Ets Variant Protein 4><Extracellular Signal-Regulated Kinase Gene><Funding><Gene Transcription><Genetic><Genetic Transcription><Genomics><Goals><Human><Hyperactivity><Intracellular Communication and Signaling><Investigators><Laboratories><Lead><Lung Adenocarcinoma><MAP Kinase Gene><MAPK><MEKs><Malignant><Malignant - descriptor><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Mammalian Cell><Mediating><Medical Oncologist><Mentors><Mentorship><Metabolic Protein Degradation><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Microscopy><Mitogen-Activated Protein Kinase Gene><Modeling><Modern Man><Molecular><Molecular Interaction><Molecular Target><NIH><National Institutes of Health><Nature><Neoplasm Metastasis><Nuclear Export><Oncogenes><Oncogenic><Oncologist><Operative Procedures><Operative Surgical Procedures><Output><PEAS3><Pathway interactions><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pb element><Ph.D.><PhD><Phosphorylation><Phosphorylation Site><Physicians><Pre-Clinical Model><Preclinical Models><Protein Phosphorylation><Protein Turnover><Publications><Pulmonary Cancer><Pulmonary malignant Neoplasm><RNA Expression><Recurrence><Recurrent><Regulation><Regulatory Protein Degradation><Repression><Research><Research Personnel><Research Resources><Research Support><Researchers><Resources><San Francisco><Scientific Publication><Scientist><Secondary Neoplasm><Secondary Tumor><Signal Transduction><Signal Transduction Systems><Signaling><Site-Directed Mutagenesis><Site-Specific Mutagenesis><Substrate Specificity><Surgical><Surgical Interventions><Surgical Procedure><Targeted DNA Modification><Targeted Modification><Techniques><Testing><Therapeutic><Thorace><Thoracic><Thorax><Training><Transcription><Transcription Regulation><Transcription Repressor><Transcriptional Control><Transcriptional Regulation><Transcriptional Repressor><Transforming Genes><Translational Research><Translational Research Enterprise><Translational Science><United States National Institutes of Health><Universities><base><biological signal transduction><cancer cell><cancer metastasis><career development><clinical translation><developmental><efficacy testing><ets variant 4><experiment><experimental research><experimental study><genetic repressor><heavy metal Pb><heavy metal lead><human disease><improved outcome><in vivo><in vivo Model><inhibitor><innovate><innovation><innovative><loss of function mutation><lung cancer><lung cancer cell><malignancy><molecular targeted therapeutics><molecular targeted therapies><molecular targeted treatment><mouse model><murine model><neoplasm/cancer><novel><pathway><patient population><patient subgroups><patient subpopulations><patient subsets><patient subtypes><phospho-proteomics><phosphoproteomics><pre-clinical><pre-clinical trial><preclinical><preclinical trial><prevent><preventing><protein degradation><protein expression><small molecule inhibitor><surgery><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tool><translation research><translation research enterprise><translational medicine><translational research program><tumor><tumor cell metastasis>
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Niranjana Natarajan

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 26/100
Training-friendly
Career award
$163,868
FY 2023

Project Title

Investigating the Role of Macrophages in Heart Failure with Preserved Ejection Fraction

Grant Number:

5K99HL157689-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

6/1/2022

End Date:

8/11/2024

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

CHALLENGE: Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome that presents with heart failure symptoms, unaltered left ventricular ejection fraction, and is associated with comorbidities including obesity, diabetes and metabolic syndrome. HFpEF accounts for ~50% o...

Research Terms

<4-D Echocardiography><4D Echocardiography><Age><Animal Model><Animal Models and Related Studies><B-Cell Differentiation Factor Gene><B-Cell Stimulatory Factor 2 Gene><BSF-2 Gene><BSF2 Gene><Beta-2 Gene Interferon><Biological Markers><Biology><Blood Plasma><Blood Vessels><C3 a><C3AR><C3AR1><C3AR1 gene><C3a><Cardiac><Cardiac infarction><Cardiology><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell-Extracellular Matrix><Cells><Chemotactic Cytokines><Clinical><Clinical Research><Clinical Study><Clinical Trials><Collaborations><Committee Members><Common Rat Strains><Complement><Complement 3><Complement 3a><Complement Activation><Complement C3a><Complement Component 3><Complement Proteins><Complex><Data><Development Plans><Diabetes Mellitus><Dichloromethylene Diphosphonate><Disease><Disorder><Dysfunction><ECM><EFRAC><ELISA><Ejection Fraction><Environment><Enzyme-Linked Immunosorbent Assay><Epidemic><Exhibits><Extracellular Matrix><Fellowship><Fibroblasts><Fibrosis><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Four-Dimensional Echocardiography><Functional disorder><Gene Expression><Genes><Glucose Intolerance><Goals><Grant><HSF Gene><Heart><Heart Vascular><Heart failure><Hepatocyte Stimulatory Factor Gene><High Fat Diet><Histology><Homologous Chemotactic Cytokines><Hybridoma Growth Factor Gene><Hypertension><IFNB2 Gene><IL-6 Gene><IL6><IL6 gene><Immune><Immunes><Immunoblotting><Immunology><In Vitro><Infiltration><Inflammasome><Inflammation><Inflammatory><Inflammatory Response><Innate Immunity><Institute of Medicine><Institute of Medicine (U.S.)><Intercrines><Interleukin 6 (Interferon, Beta 2) Gene><Interleukin-6 Gene><Intracellular Communication and Signaling><Investigation><Investigators><Knowledge><LV remodeling><LVEF><Laboratories><Left Ventricles><Left Ventricular Ejection Fraction><Left Ventricular Remodeling><Left ventricular structure><Liposomal><Liposomes><Macrophage><Measures><Mediating><Mentors><Mentorship><Metabolic syndrome><Mice><Mice Mammals><Modeling><Molecular><Murine><Mus><Myocardial Infarct><Myocardial Infarction><Myofibroblast><Mφ><NAS/IOM><Native Immunity><Natural Immunity><Non-Specific Immunity><Nonspecific Immunity><Obesity><Pathologic><Pathology><Pathway interactions><Patients><Phase><Phenotype><Physiology><Physiopathology><Pilot Projects><Plasma><Plasma Serum><Play><Population><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Proliferating><Rat><Rats Mammals><Rattus><Receptor Protein><Regulation><Relaxation><Research><Research Activity><Research Associate><Research Personnel><Research Resources><Researchers><Resolution><Resources><Reticuloendothelial System, Serum, Plasma><Role><SIS cytokines><Sampling><Signal Transduction><Signal Transduction Systems><Signaling><Stress><Symptoms><Syndrome><Systems Biology><Testing><Time><Training><United States><Universities><Up-Regulation><Upregulation><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Ventricular><Western Blotting><Western Immunoblotting><Work><Writing><adiposity><ages><arm><base><bases><bio-markers><biologic marker><biological signal transduction><biomarker><cardiac failure><cardiac fibrosis><cardiac infarct><cardiovascular disorder><career><career development><chemoattractant cytokine><chemokine><circulatory system><clodronate><co-morbid><co-morbidity><cobra venom factor><comorbidity><compare to control><comparison control><complement pathway><complement pathway regulation><complement system><confocal imaging><coronary attack><coronary fibrosis><coronary infarct><coronary infarction><corpulence><cytokine><diabetes><dietary><enzyme linked immunoassay><evidence base><experiment><experimental research><experimental study><experiments><flow cytophotometry><frontier><heart attack><heart infarct><heart infarction><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><improved><left ventricle remodeling><model of animal><myocardial fibrosis><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><pathophysiology><pathway><pilot study><post-doc><post-doctoral><post-doctoral trainee><post-doctoral training><postdoctoral training><preservation><protein blotting><receptor><research associates><resolutions><social role><systemic inflammation><systemic inflammatory response><therapeutic target><transcriptomics><vascular><vascular endothelial dysfunction>
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Gregory Corder

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Exploratory lead · 26/100
Likely hiring
$150,581
FY 2022

Project Title

Harnessing cortical neuromodulation to disrupt pain perception

Grant Number:

3DP2GM140923-01S1

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2020

End Date:

5/31/2025

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Chronic pain is characterized by sensory, emotional, and cognitive dysfunction. Some patients on opioid therapies can perceive the negative valence of pain as separate, or “dissociated,” from the sensation of pain. This suggests that altering the affective-attention dimension of pain...

Research Terms

<Acute><Affective><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Anterior><Area><Attention><Award><Behavior><Brain><Brain Nervous System><Brain Stem><Brain region><Brainstem><Breathing><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Dangerousness><Data Analyses><Data Analysis><Development><Dimensions><Disease><Disorder><Disturbance in cognition><Emotional><Encephalon><Goals><Immediate Memory><Impaired cognition><Medical><Methods><Molecular><Negative Valence><Neuranatomies><Neuranatomy><Neuroanatomies><Neuroanatomy><Neurobiology><Neurosciences><Nociception><Nociceptive Impulse><Nociceptive Stimulus><Opiates><Opioid><Opioid Analgesics><Pain><Painful><Parents><Patients><Prefrontal Cortex><Research><Respiratory Aspiration><Respiratory Depression><Respiratory Inspiration><Rewards><Role><Route><Sensory><Short-Term Memory><Shortterm Memory><Stimulus><Technology><Thalamic structure><Thalamus><Therapeutic><Therapeutic Effect><Training><Ventilatory Depression><Viral Genetics><amygdaloid nuclear complex><base><career><cell type><chronic pain><chronic pain control><chronic pain intervention><chronic pain management><chronic pain therapy><chronic pain treatment><cingulate cortex><cognitive dysfunction><cognitive loss><data interpretation><depressed breathing><depression of breathing><developmental><directed attention><directs attention><experiment><experimental research><experimental study><genetic technology><improved><inspiration><machine vision><mouse genetics><mu opioid receptors><neural circuit><neural circuitry><neural control><neural regulation><neurobiological><neurocircuitry><neuromodulation><neuromodulatory><neuroregulation><nociceptive><opiate analgesia><opiate analgesic><opiate crisis><opiate pain medication><opiate pain reliever><opiate therapy><opioid analgesia><opioid anesthetic><opioid crisis><opioid epidemic><opioid pain medication><opioid pain reliever><opioid painkiller><opioid therapy><pain behavior><pain perception><pain processing><pain sensation><painful sensation><prevent><preventing><receptor binding><receptor bound><side effect><social role><statistics><synaptic circuit><synaptic circuitry><thalamic><treat chronic pain><virus genetics><working memory><μ opioid receptors><μ-OR><μOR>
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Pablo Penaloza-MacMaster

NORTHWESTERN UNIVERSITY AT CHICAGO, CHICAGO, IL

Exploratory lead · 26/100
Likely hiring
$81,547
FY 2023

Project Title

Interferon-modulated vaccines against HIV

Grant Number:

3DP2DA051912-01S2

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2020

End Date:

6/30/2024

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary The main goal of the parent grant is to develop interferon-modulated vaccines against HIV. The proposed research will follow up on the same unifying concept of our parent DP2 grant, but in addition, it will consider the effect of boosting with a heterologous vaccine. Bakare has obser...

Research Terms

<2019-nCoV vaccine><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Active Follow-up><Affect><COVID-19 vaccine><COVID19 vaccine><Data><Goals><Grant><HIV><HIV Infections><HIV vaccine><HIV/AIDS Vaccines><HTLV-III Infections><HTLV-III-LAV Infections><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Infections><IFN><Infectious Agent><Injecting drug user><Injection Drug User><Interferons><LAV-HTLV-III><Lymphadenopathy-Associated Virus><Manuscripts><PWID><Parents><Persons><Predisposition><Preparation><Regimen><Research><SARS-CoV-2 vaccine><SARS-CoV2 vaccine><SARS-coronavirus-2 vaccine><Severe Acute Respiratory Syndrome CoV 2 vaccine><Severe acute respiratory syndrome coronavirus 2 vaccine><Substance Use Disorder><Susceptibility><Vaccines><Viral Vaccines><Virus-HIV><active followup><corona virus disease 2019 vaccine><coronavirus disease 2019 vaccine><coronavirus disease-19 vaccine><follow up><follow-up><followed up><followup><human immunodeficiency virus vaccine><immunogenic><improved><infectious organism><nCoV vaccine><nCoV-19 vaccine><nCoV19 vaccine><novel><parent><parent grant><people who inject drugs><people who inject illicit drugs><persons who inject drugs><preparations><substance use and disorder><vaccine against 2019-nCov><vaccine against SARS-CoV-2><vaccine against SARS-CoV2><vaccine against SARS-coronavirus-2><vaccine against Severe Acute Respiratory Syndrome CoV 2><vaccine against Severe acute respiratory syndrome coronavirus 2><vaccine efficacy><vaccine for novel coronavirus>
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Kiera L. Clayton

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

Exploratory lead · 26/100
Likely hiring
$39,280
FY 2024

Project Title

Administrative Supplement: Characterizing Macrophages as "Hide-Outs" for Chronic Pathogens

Grant Number:

3DP2AI154438-03S1

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2021

End Date:

3/19/2024

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY This proposal describes the framework of an NIAID New Innovators DP2 award for Kiera Clayton, PhD. Dr. Clayton is currently a postdoctoral fellow under the supervision of Dr. Bruce Walker at the Ragon Institute of MGH, MIT and Harvard, whose current research focuses on T cell and NK ...

Research Terms

<AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Administrative Supplement><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Area><Award><CMV><Candidate Disease Gene><Candidate Gene><Cell Body><Cells><Cessation of life><Characteristics><Chronic><Cytomegalovirus><Cytotoxic cell><Data><Death><Development><Doctor of Philosophy><Future><Goals><Granzyme><HCMV><HIV><HIV Infections><HIV/Mtb><HIV/TB><HIV/mycobacterium tuberculosis><HIV/tuberculosis><HTLV-III Infections><HTLV-III-LAV Infections><Human><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Infections><Immune><Immune Evasion><Immune response><Immunes><Immunological response><Induction of Apoptosis><Infection><Inflammation><K lymphocyte><Knock-out><Knockout><LAV-HTLV-III><Lymphadenopathy-Associated Virus><M tb><M tuberculosis><M tuberculosis infection><M. tb><M. tb infection><M. tuberculosis><M. tuberculosis infection><M. tuberculosis/HIV><M.tb infection><M.tuberculosis infection><MTB infection><Macrophage><Mediating><Methods><Miscellaneous Antibiotic><Mission><Modern Man><Mycobacterium tuberculosis><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><Mφ><NIAID><NK Cells><National Institute of Allergy and Infectious Disease><Natural Killer Cells><Pathway interactions><Ph.D.><PhD><Postdoc><Postdoctoral Fellow><Predisposition><Publishing><Research><Research Associate><Resistance><Salivary Gland Viruses><Supervision><Susceptibility><T cell response><T-Cells><T-Lymphocyte><TB infection><Tuberculosis><Virus-HIV><Work><antigen-specific T cells><antiretroviral therapy><antiretroviral treatment><cell killing><cytomegalovirus group><design><designing><developmental><disseminated TB><disseminated tuberculosis><host response><immune evasive><immune system response><immunoresponse><infection due to Mycobacterium tuberculosis><inhibitor><insight><mtb><pathogen><pathway><post-doc><post-doctoral><post-doctoral trainee><prevent><preventing><research associates><resistant><therapeutic agent development><therapeutic development><thymus derived lymphocyte><tuberculosis infection><tuberculous spondyloarthropathy>
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Subhamoy Dasgupta

ROSWELL PARK CANCER INSTITUTE CORP, BUFFALO, NY

Exploratory lead · 26/100
Likely hiring
$20,175
FY 2024

Project Title

Decoding the nuclear metabolic processes regulating gene transcription

Grant Number:

3DP2CA260421-01S1

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2023

End Date:

5/31/2024

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

In this High Risk High Reward DP2 application I wish to investigate the nuclear functions of mitochondrial metabolic enzymes. It is quite evident from current literature that many of the mitochondrial enzymes are localized to the nucleus, more so in diseased conditions such as cancer. However, there...

Research Terms

<ATP Citrate (pro-3S)-Lyase><ATP Citrate (pro-S)-Lyase><ATP Citrate Lyase><ATP citrate pro3s lyase><ATP-Dependent Citrate Lyase><Aconitase><Aconitate Hydratase><Automobile Driving><Basal Transcription Factor><Basal transcription factor genes><Biological Function><Biological Process><Biomedical Research><Cancers><Cell Communication and Signaling><Cell Nucleus><Cell Signaling><ChIP assay><Chromatin><Citrate (si)-Synthase><Citrate Cleavage Enzyme><Citrate Hydrolyase><Citrate Synthase><Citrate(isocitrate) hydro-lyase><Communication><Complex><Coupled><Disease><Disorder><Disseminated Malignant Neoplasm><Enzyme Gene><Enzymes><Event><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Genes><Genetic Transcription><Glutarates><Growth><Intermediary Metabolism><Intracellular Communication and Signaling><Isocitrate Hydro-Lyase><Knowledge><Literature><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic Pathway><Metabolic Processes><Metabolic stress><Metabolism><Metastatic Cancer><Metastatic Malignant Neoplasm><Mitochondria><Multienzyme Complexes><Nuclear><Nucleus><Oncogenic><Process><Proteomics><RNA Expression><Reporting><Role><Signal Transduction><Signal Transduction Systems><Signaling><Spatial Distribution><Thesaurismosis><Tissue Growth><Transcript Expression Analyses><Transcript Expression Analysis><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><analyze gene expression><biological signal transduction><cancer cell><cancer progression><chromatin immunoprecipitation><citrate pro3s lyase><driving><enzyme complex><gene expression analysis><gene expression assay><high reward><high risk><malignancy><metabolism disorder><metabolism measurement><metabolomics><metabonomics><mitochondrial><neoplasm progression><neoplasm/cancer><neoplastic progression><novel><ontogeny><programs><pyruvate dehydrogenase><recruit><social role><transcription factor><transcriptional profiling><transcriptional reprogramming><tumor progression>
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Joseph M Salvino

WISTAR INSTITUTE, PHILADELPHIA, PA

Exploratory lead · 18/100
Above-average budget
$566,728
FY 2021

Project Title

Purchase of an Echo 650 acoustic liquid handler with Access workstation

Grant Number:

1S10OD030245-01

Activity Code:

S10

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

7/1/2021

End Date:

6/30/2022

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Support is requested for the purchase of an Echo 650 acoustic liquid handler with Access workstation to replace the Janus NanoHead, the existing and aging low volume liquid handler purchased in 2008 within the Molecular Screening and Protein Expression Facility at The Wistar Institu...

Research Terms

<Academic support><Acoustic><Acoustics><Aging><Assay><Bioassay><Biochemical><Biologic Assays><Biological Assay><CCSG><Cancer Center Support Grant><Cell Body><Cells><Data><Decision Making><Development><Drug Industry><Grant><Grant Review><High Throughput Assay><Infrastructure><Investigators><Liquid substance><Miniaturisations><Miniaturization><Minor><Molecular><NIH><National Institutes of Health><Pharmaceutic Industry><Pharmaceutical Industry><Philadelphia><Principal Investigator><Research><Research Personnel><Researchers><Source><Structure-Activity Relationship><Technology><The Wistar Institute><United States National Institutes of Health><base><chemical structure function><cost><developmental><drug discovery><experience><fluid><high throughput screening><improved><instrument><liquid><miniaturize><nano litre><nanoliter><nanolitre><novel><protein expression><recruit><screening><small molecule><sound><structure function relationship>
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Nir Hacohen

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 10/100
Solid budget
$299,500
FY 2023

Project Title

A microscope for ultra-high multiplex spatial imaging of transcripts and proteins in tissues

Grant Number:

1S10OD032278-01A1

Activity Code:

S10

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2024

Project Abstract

In this proposal, 13 NIH-funded faculty from the Massachusetts General Hospital request to purchase a Vizgen MERSCOPE. The MERSCOPE is a new technology for multiplex measurement of up to 550 genes in tissue from any organism, including human. The technology offers exceptional accuracy, reproducibili...

Research Terms

<Award><Back><Body Tissues><Boston><Cancer Center><Cell Body><Cell Communication><Cell Interaction><Cell-to-Cell Interaction><Cells><Colo-rectal Cancer><Colorectal Cancer><Communities><Core Facility><Data><Data Set><Disease><Disorder><Dorsum><Equipment><Faculty><Funding><General Hospitals><Genes><Genomics><Grant><Health><Human><Image><Imaging Device><Imaging Instrument><Imaging Tool><Imaging technology><Institution><Investigators><Maps><Massachusetts><Measurement><Methodology><Microscope><Minor><Modern Man><NIH><National Institutes of Health><Non-Polyadenylated RNA><Organism><Preparation><Proteins><Protocol><Protocols documentation><RNA><RNA Gene Products><Reproducibility><Research><Research Personnel><Researchers><Resolution><Ribonucleic Acid><System><Technology><Tissues><Transcript><United States National Institutes of Health><cell type><imaging><instrument><living system><member><molecular pathology><new technology><novel technologies><preparations><resolutions><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><transcriptomics>
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Niranjana Natarajan

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 10/100
Active award
$249,000
FY 2025

Project Title

Investigating the Role of Macrophages in Heart Failure with Preserved Ejection Fraction

Grant Number:

5R00HL157689-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/12/2024

End Date:

7/31/2027

Project Abstract

CHALLENGE: Heart failure with preserved ejection fraction (HFpEF) is a complex clinical syndrome that presents with heart failure symptoms, unaltered left ventricular ejection fraction, and is associated with comorbidities including obesity, diabetes and metabolic syndrome. HFpEF accounts for ~50% o...

Research Terms

<4-D Echocardiography><4D Echocardiography><Animal Model><Animal Models and Related Studies><B-Cell Differentiation Factor Gene><B-Cell Stimulatory Factor 2 Gene><BSF-2 Gene><BSF2 Gene><Beta-2 Gene Interferon><Biological Markers><Biology><Blood Plasma><Blood Vessels><C3 a><C3AR><C3AR1><C3AR1 gene><C3a><Cardiac><Cardiac infarction><Cardiology><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell-Extracellular Matrix><Cells><Chemotactic Cytokines><Clinical><Clinical Research><Clinical Study><Clinical Trials><Collaborations><Committee Members><Common Rat Strains><Complement><Complement 3><Complement 3a><Complement Activation><Complement C3a><Complement Component 3><Complement Proteins><Complex><Data><Development Plans><Diabetes Mellitus><Diastolic heart failure><Dichloromethylene Diphosphonate><Disease><Disorder><Dysfunction><ECM><EFRAC><ELISA><Ejection Fraction><Environment><Enzyme-Linked Immunosorbent Assay><Epidemic><Exhibits><Extracellular Matrix><Fellowship><Fibroblasts><Fibrosis><Fibrosis in the heart><Fibrosis in the myocardium><Fibrosis within the heart><Fibrosis within the myocardium><Fibrotic myocardium><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Four-Dimensional Echocardiography><Functional disorder><Gene Expression><Genes><Glucose Intolerance><Goals><Grant><HF with preserved ejection fraction><HFpEF><HSF Gene><Heart><Heart Vascular><Heart failure><Hepatocyte Stimulatory Factor Gene><High Fat Diet><Histology><Homologous Chemotactic Cytokines><Hybridoma Growth Factor Gene><Hypertension><IFNB2 Gene><IL-6 Gene><IL6><IL6 gene><Immune><Immunes><Immunoblotting><Immunology><In Vitro><Infiltration><Inflammasome><Inflammation><Inflammatory><Inflammatory Response><Innate Immunity><Institute of Medicine><Institute of Medicine (U.S.)><Intercrines><Interleukin 6 (Interferon, Beta 2) Gene><Interleukin-6 Gene><Intracellular Communication and Signaling><Investigation><Investigators><Knowledge><LV remodeling><LVEF><Laboratories><Left Ventricles><Left Ventricular Ejection Fraction><Left Ventricular Remodeling><Left ventricular structure><Liposomal><Liposomes><Macrophage><Measures><Mediating><Mentors><Mentorship><Metabolic syndrome><Mice><Mice Mammals><Modeling><Molecular><Murine><Mus><Myocardial Infarct><Myocardial Infarction><Myofibroblast><Mφ><NAS/IOM><Native Immunity><Natural Immunity><Non-Specific Immunity><Nonspecific Immunity><Obesity><Pathologic><Pathology><Pathway interactions><Patients><Phase><Phenotype><Physiology><Physiopathology><Pilot Projects><Plasma><Plasma Serum><Play><Population><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Proliferating><Rat><Rats Mammals><Rattus><Receptor Protein><Regulation><Relaxation><Research><Research Activity><Research Associate><Research Personnel><Research Resources><Researchers><Resolution><Resources><Reticuloendothelial System, Serum, Plasma><Role><SIS cytokines><Sampling><Signal Transduction><Signal Transduction Systems><Signaling><Stress><Symptoms><Syndrome><Systems Biology><Testing><Time><Training><United States><Universities><Upregulation><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Ventricular><Western Blotting><Western Immunoblotting><Work><Writing><adiposity><age associated><age correlated><age dependent><age linked><age related><age specific><arm><base><bases><bio-markers><biologic marker><biological signal transduction><biomarker><cardiac failure><cardiac fibrosis><cardiac infarct><cardiovascular disorder><career><career development><chemoattractant cytokine><chemokine><circulatory system><clodronate><co-morbid><co-morbidity><cobra venom factor><comorbidity><compare to control><comparison control><complement pathway><complement pathway regulation><complement system><complementation><confocal imaging><coronary attack><coronary fibrosis><coronary infarct><coronary infarction><corpulence><cytokine><diabetes><dietary><enzyme linked immunoassay><evidence base><experiment><experimental research><experimental study><experiments><fibrotic heart><flow cytophotometry><heart attack><heart failure with preserved ejection fraction><heart failure with preserved systolic function><heart fibrosis><heart infarct><heart infarction><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><improved><left ventricle remodeling><model of animal><myocardial fibrosis><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><pathophysiology><pathway><pilot study><post-doc><post-doctoral><post-doctoral trainee><post-doctoral training><preservation><preserved ejection fraction heart failure><protein blotting><receptor><research associates><resolutions><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><systemic inflammation><systemic inflammatory response><therapeutic target><vascular><vascular endothelial dysfunction>
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Sunil Kumar

ST. JOHN'S UNIVERSITY, QUEENS, NY

Exploratory lead · 10/100
Active award
$187,500
FY 2025

Project Title

Investigating the role of Lipocalin Prostaglandin D2 Synthase and its metabolite PGD2 in non-alcoholic fatty liver disease

Grant Number:

5R16GM150498-02

Activity Code:

R16

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/10/2024

End Date:

6/30/2028

Project Abstract

PROJECT SUMMARY/ABSTRACT Despite non-alcoholic fatty liver disease (NAFLD) being the most common chronic liver disease worldwide, molecular mechanisms contributing to its etiology and progression are still unclear. This gap in knowledge has prevented the understanding of basic biology, pathogenesis,...

Research Terms

<APOE><Address><Affect><Agonist><Apo-E><ApoE protein><Apolipoprotein E><Arachidonic Acid Cyclooxygenase><Biology><Causality><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Control Groups><Cyclo-Oxygenase><Cyclooxygenase><D2 receptor><DRD2 Receptor><Data><Dedications><Development><Diabetes Mellitus><Disease><Disorder><Dopamine D2 Receptor><Drug Therapy><Dysfunction><Etiology><Exhibits><FDA approved><Fat-Restricted Diet><Fatty Acid Cyclo-Oxygenase><Functional disorder><Future><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><GPCR><Gene Expression><Glycolysis><Glycoproteins><Goals><Hep G2><HepG2><HepG2 cell line><Hepatic><High Fat Diet><Humulin R><Hydroperoxide Cyclase><Immune response><In Vitro><Incidence><Individual><Injury to Liver><Insulin><Insulin Resistance><Intracellular Communication and Signaling><Isomerism><KO mice><Knock-out Mice><Knockout Mice><Knowledge><Learning><Link><Lipids><Liver><Low-Fat Diet><Metabolic><Metabolic Diseases><Metabolic Disorder><Mice><Mice Mammals><Modeling><Molecular><Murine><Mus><NAFLD><Names><Novolin R><Null Mouse><Obesity><PGD2><PGH Synthase><PGH2 Synthetase><Pathogenesis><Pathway interactions><Patients><Pharmacological Treatment><Pharmacotherapy><Physiologic><Physiological><Physiology><Physiopathology><Play><Population><Prostaglandin Cyclo-Oxygenase><Prostaglandin Cyclooxygenase><Prostaglandin D2><Prostaglandin Endoperoxide Synthetase><Prostaglandin G-H Synthase><Prostaglandin H Synthase><Prostaglandin H2 Synthetase><Prostaglandin Synthase><Prostaglandin Synthetase><Prostaglandin-Endoperoxide Synthase><Proteins><Receptor Protein><Regular Insulin><Regulation><Research><Role><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Testing><Therapeutic><Thesaurismosis><Triacylglycerol><Triglycerides><Universities><Weight Gain><Weight Increase><Work><adipogenesis><adiposity><allergen response><allergic response><allergy response><antagonism><antagonist><biological signal transduction><body weight gain><body weight increase><causation><chronic hepatic disease><chronic hepatic disorder><chronic liver disease><chronic liver disorder><compare to control><comparison control><corpulence><curative intervention><curative therapeutic><curative therapy><curative treatments><db/db mouse><developmental><diabetes><disease causation><disease phenotype><drug intervention><drug treatment><fat metabolism><fatty acid oxidation><fatty liver disease><glucose metabolism><graduate student><hepatic body system><hepatic damage><hepatic injury><hepatic organ system><host response><human disease><immune system response><immunoresponse><in vitro Model><innovate><innovation><innovative><insulin resistant><insulin signaling><insulin tolerance><isomer><life style intervention><lifestyle intervention><lipid biosynthesis><lipid metabolism><lipogenesis><liver damage><liver injury><mRNA Expression><metabolism disorder><metabolism measurement><metabolomics><metabonomics><name><named><naming><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapeutics><new therapy><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><next generation therapeutics><non-alcohol fatty liver disease><non-alcoholic fatty liver disease><non-alcoholic liver disease><nonalcoholic fatty liver disease><novel><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapeutics><novel therapy><novel therapy approach><novel therapy target><overexpress><overexpression><pathophysiology><pathway><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><prevent><preventing><protein expression><receptor><social role><therapeutic target><transcriptomics><undergraduate research experience><undergraduate research opportunities><undergraduate research programs><wt gain>
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Michaela Larson

FLORIDA INTERNATIONAL UNIVERSITY, MIAMI, FL

Exploratory lead · 10/100
Active award
$54,000
FY 2025

Project Title

Nothing Micro About It: Investigating the Role of miRNAs and Cannabis Use in Cardiac Dysfunction among People Living with HIV

Grant Number:

1R36DA062542-01A1

Activity Code:

R36

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2025

End Date:

5/31/2027

Project Abstract

PROJECT SUMMARY Overview. This dissertation research study proposes to examine epigenetic profiles of cardiac dysfunction in people with HIV (PWH) who use and do not use cannabis. Specifically, we will examine microRNA (miRNA) profiles of cardiac dysfunction, and investigate how cannabis use, and it...

Research Terms

<9-ene-Tetrahydrocannabinol><AIDS Virus><ASCVD><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Antioxidants><Apoptosis><Apoptosis Pathway><Area><Arrhythmia><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Award><Biological Markers><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Cannabidiol><Cannabinoids><Cannabis><Cardiac><Cardiac Arrhythmia><Cardiac infarction><Cardiology><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular Physiology><Cardiovascular system><Cell Differentiation><Cell Differentiation process><Cellular Expansion><Cellular Growth><Chronic><Clinical><Communication><Cross Sectional Analysis><Cross-Sectional Analyses><Cross-Sectional Studies><Cross-Sectional Survey><D9-tetrahydrocannabinol><Data><Delta-9-Tetrahydrocannabinol><Development><Disease><Disease Frequency Surveys><Disease Outcome><Disorder><Dose><Epidemiologist><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Foundations><Functional RNA><Gene Expression><Goals><HIV><Heart Arrhythmias><Heart Vascular><Heart failure><Human Immunodeficiency Viruses><Hypertension><Image><Immune Cell Activation><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Inflammation><LAV-HTLV-III><Link><Lymphadenopathy-Associated Virus><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mentors><Messenger RNA><Methods><MicroRNA Expression Profiling><MicroRNAs><Modernization><Molecular><Myocardial Infarct><Myocardial Infarction><Myocardial depression><Myocardial dysfunction><NGS Method><NGS system><NIDA><NMR Imaging><NMR Tomography><National Institute of Drug Abuse><National Institute on Drug Abuse><Neuroimmune><Noncoding RNA><Nontranslated RNA><Nuclear Magnetic Resonance Imaging><Onset of illness><Outcome><Parents><Pathogenesis><Persons><Pharmacology><Platelet aggregation><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Preventative treatment><Preventive treatment><Programmed Cell Death><Proliferating><Protein Modification><Proteomics><R-Series Research Projects><R01 Mechanism><R01 Program><Regimen><Reporting><Research><Research Grants><Research Project Grants><Research Projects><Research Proposals><Risk><Risk Factors><Role><Sampling><Systems Development><THC co-use><THC concentration><THC use><Tetrahydrocannabinol><Tetrahydrocannabinol co-use><Tetrahydrocannabinol use><Training><Untranslated RNA><Urine><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Viral><Viral Burden><Viral Load><Viral Load result><Virus-HIV><Whole Blood><Woman><Zeugmatography><accelerated aging><accelerated biological age><accelerated biological aging><age acceleration><antiretroviral therapy><antiretroviral treatment><atheromatosis><atherosclerotic disease><atherosclerotic vascular disease><bio-markers><biologic marker><biological adaptation to stress><biomarker><cannabis use><cannabis user><cardiac MRI><cardiac dysfunction><cardiac failure><cardiac infarct><cardiac magnetic resonance imaging><cardiometabolic risk><cardioprotectant><cardioprotection><cardioprotective><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder risk><cardiovascular function><career><cell growth><cellular differentiation><circulatory system><clinical relevance><clinically relevant><coronary attack><coronary infarct><coronary infarction><death risk><delta(1)-THC><delta(1)-Tetrahydrocannabinol><delta(9)-THC><delta(9)-Tetrahydrocannabinol><developmental><differential expression><differentially expressed><disease onset><disorder onset><early onset><epigenetically><epigenomics><experience><global miRNA profiling><heart attack><heart dysfunction><heart infarct><heart infarction><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><imaging><immune activation><indexing><innovate><innovation><innovative><mRNA><malleable risk><marijuana use><marijuana user><men><miRNA><miRNA expression profiling><miRNA sequencing><miRNA-seq><micro RNA expression profiling><microRNA profiling><microRNA sequencing><modifiable risk><mortality risk><next gen sequencing><next generation sequencing><nextgen sequencing><noncoding><novel><parent><pre-clinical><preclinical><reactioncrisis><research study><response><social role><stress response><stressreaction><substance use><substance using><success><systemic inflammation><systemic inflammatory response><tetrahydrocannabinol concentration><transcriptional differences><Δ(1)-THC><Δ(1)-tetrahydrocannabinol><Δ(9)-THC><Δ(9)-tetrahydrocannabinol><Δ-9-tetrahydrocannabinol><Δ9-tetrahydrocannabinol>
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Matthew Lovett-Barron

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Exploratory lead · 0/100
$247,791
FY 2022

Project Title

Discovery and characterization of brain-wide neuromodulatory circuits regulating arousal

Grant Number:

5R00MH112840-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/3/2020

End Date:

5/31/2023

Project Abstract

Project Summary This proposal will be moved from the mentored phase institution (Stanford University) to the R00 institution (University of California, San Diego). No changes have been made to the experimental plans, and the current proposal is specific to the R00 phase. I have completed the aims I ...

Research Terms

<5-HT><5-Hydroxytryptamine><5HT><AD/HD><ADHD><Ablation><Animals><Anxiety><Arousal><Attention deficit hyperactivity disorder><Autopsy><Award><Behavior><Brachydanio rerio><Brain><Brain Mapping><Brain Nervous System><Brain imaging><California><Cardiac Chronotropism><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Communities><Complex><Danio rerio><Data><Dimensions><Dopamine><Encephalon><Enteramine><Fishes><Functional Imaging><Funding><Goals><Grant><Head><Heart Rate><Hippophaine><Human><Hydroxytyramine><Image><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Individual><Institution><Intracellular Communication and Signaling><Investigation><Investigators><Knowledge><Levarterenol><Levonorepinephrine><Link><Locus Coeruleus><Mammalia><Mammals><Measures><Mental Depression><Mental disorders><Mental health disorders><Mentors><Methods><Modern Man><Molecular><NIMH><National Institute of Mental Health><Nature><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neuromodulator><Neurons><Neurosciences><Noradrenaline><Norepinephrine><Nucleus Pigmentosus Pontis><Performance><Phase><Phenotype><Physiologic Imaging><Position><Positioning Attribute><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Primates><Primates Mammals><Probability><Psychiatric Disease><Psychiatric Disorder><Publications><RDoC><Reaction Time><Receptor Protein><Research Domain Criteria><Research Personnel><Researchers><Resolution><Response RT><Response Time><Role><Schizophrenia><Schizophrenic Disorders><Scientific Publication><Sensory><Serotonin><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Speed><Survey Instrument><Surveys><System><Techniques><Testing><Training><Universities><Vertebrate Animals><Vertebrates><Work><Zebra Danio><Zebra Fish><Zebrafish><attention deficit hyperactive disorder><basal forebrain><behavior influence><behavior study><behavioral influence><behavioral study><biological signal transduction><blue nucleus><brain visualization><career development><cell type><cholinergic><cognitive function><common symptom><common treatment><dementia praecox><depression><emotional functioning><experiment><experimental research><experimental study><imaging><innovate><innovation><innovative><locus ceruleus structure><mental illness><necropsy><neural><neural control><neural regulation><neurochemical><neurochemistry><neuromodulation><neuromodulatory><neuronal><neuroregulation><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><noradrenergic><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><optic imaging><optical imaging><optogenetics><perceptual stimulus><physicochemical phenomena related to the senses><physiological imaging><postmortem><psychiatric illness><psychological disorder><psychomotor reaction time><rational design><receptor><relating to nervous system><response><schizophrenic><sensory stimulus><skills><social role><technique development><tool><vertebrata><visual motor><visuomotor>
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Alicia M Allen

UNIVERSITY OF ARIZONA, TUCSON, AZ

Exploratory lead · 0/100
$191,875
FY 2024

Project Title

Evaluating Social Connectedness to Support Recovery from Opioid Use Disorder during the Postpartum Period

Grant Number:

5R21DA058364-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2023

End Date:

4/30/2025

Project Abstract

PROJECT SUMMARY The prevalence of opioid use disorder (OUD) during pregnancy has increased by nearly 500% over the past 15 years. While motivation for and compliance with OUD treatment during pregnancy is heightened, up to 80% of postpartum individuals with OUD relapse to illicit opioid use within s...

Research Terms

<0-11 years old><Academic achievement><Anxiety><Behavioral><Birth><Buffers><Cell Communication and Signaling><Cell Signaling><Child><Child Youth><Childbirth><Children (0-21)><Control Groups><Data><Data Analytics><Development><Ecological momentary assessment><Elements><Emotional><Evidence based treatment><Family><General Population><General Public><Generations><Gestation><Goals><Health><Individual><Infant><Intervention><Intervention Strategies><Interview><Intracellular Communication and Signaling><Knowledge><Loneliness><Machine Learning><Maternal Mortality><Medical Records><Mental Depression><Mothers><Motivation><Opiates><Opioid><Outcome><Overdose><Pain><Pain Control><Pain Therapy><Pain management><Painful><Participant><Parturition><Pattern><Perinatal><Peripartum><Play><Population><Post-Natal Depression><Post-Partum Depression><Postnatal Depression><Postpartum Depression><Postpartum Period><Pregnancy><Prevalence><Prevention><R-Series Research Projects><R01 Mechanism><R01 Program><Recovery><Recovery Support><Relapse><Research Grants><Research Project Grants><Research Projects><Risk><Risk Factors><Role><Sampling><Signal Transduction><Signal Transduction Systems><Signaling><Sleep disturbances><Social isolation><Social outcome><Social support><Specialist><Stress><Substance Use Disorder><Target Populations><Testing><Theoretic Models><Theoretical model><Time><Woman><Work><aberrant sleep><biological signal transduction><care giving><care giving burden><caregiving><caregiving burden><caregiving stress><child birth><craving><customized therapy><customized treatment><depression><developmental><disrupted sleep><disturbed sleep><foster care><fourth trimester><high risk><illicit opiate><illicit opioid><impaired sleep><improved><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><infant outcome><informant><interventional strategy><irregular sleep><kids><lonely><machine based learning><maternal death><non-medical opioid use><nonmedical opioid use><novel><opiate consumption><opiate drug use><opiate intake><opiate misuse><opiate overdose><opiate related overdose><opiate use><opiate use disorder><opioid consumption><opioid drug overdose><opioid drug use><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid misuse><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use><opioid use disorder><overdose death><overdose fatalities><pain treatment><patient specific therapies><patient specific treatment><peer support><perinatal period><perinatal phase><post-partum><prevent><prevent relapse><preventing><relapse prevention><relapse risk><sleep disruption><sleep dysregulation><social><social attachment><social bonding><social role><social support network><statistics><stress buffering><stress management><stressor><substance use and disorder><tailored medical treatment><tailored therapy><tailored treatment><unique treatment><youngster>
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Linnea B Linde-Krieger

UNIVERSITY OF ARIZONA, TUCSON, AZ

Exploratory lead · 0/100
$191,875
FY 2024

Project Title

Evaluating Social Connectedness to Support Recovery from Opioid Use Disorder during the Postpartum Period

Grant Number:

5R21DA058364-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2023

End Date:

4/30/2025

Project Abstract

PROJECT SUMMARY The prevalence of opioid use disorder (OUD) during pregnancy has increased by nearly 500% over the past 15 years. While motivation for and compliance with OUD treatment during pregnancy is heightened, up to 80% of postpartum individuals with OUD relapse to illicit opioid use within s...

Research Terms

<0-11 years old><Academic achievement><Anxiety><Behavioral><Birth><Buffers><Cell Communication and Signaling><Cell Signaling><Child><Child Youth><Childbirth><Children (0-21)><Control Groups><Data><Data Analytics><Development><Ecological momentary assessment><Elements><Emotional><Evidence based treatment><Family><General Population><General Public><Generations><Gestation><Goals><Health><Individual><Infant><Intervention><Intervention Strategies><Interview><Intracellular Communication and Signaling><Knowledge><Loneliness><Machine Learning><Maternal Mortality><Medical Records><Mental Depression><Mothers><Motivation><Opiates><Opioid><Outcome><Overdose><Pain><Pain Control><Pain Therapy><Pain management><Painful><Participant><Parturition><Pattern><Perinatal><Peripartum><Play><Population><Post-Natal Depression><Post-Partum Depression><Postnatal Depression><Postpartum Depression><Postpartum Period><Pregnancy><Prevalence><Prevention><R-Series Research Projects><R01 Mechanism><R01 Program><Recovery><Recovery Support><Relapse><Research Grants><Research Project Grants><Research Projects><Risk><Risk Factors><Role><Sampling><Signal Transduction><Signal Transduction Systems><Signaling><Sleep disturbances><Social isolation><Social outcome><Social support><Specialist><Stress><Substance Use Disorder><Target Populations><Testing><Theoretic Models><Theoretical model><Time><Woman><Work><aberrant sleep><biological signal transduction><care giving><care giving burden><caregiving><caregiving burden><caregiving stress><child birth><craving><customized therapy><customized treatment><depression><developmental><disrupted sleep><disturbed sleep><foster care><fourth trimester><high risk><illicit opiate><illicit opioid><impaired sleep><improved><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><infant outcome><informant><interventional strategy><irregular sleep><kids><lonely><machine based learning><maternal death><non-medical opioid use><nonmedical opioid use><novel><opiate consumption><opiate drug use><opiate intake><opiate misuse><opiate overdose><opiate related overdose><opiate use><opiate use disorder><opioid consumption><opioid drug overdose><opioid drug use><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid misuse><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use><opioid use disorder><overdose death><overdose fatalities><pain treatment><patient specific therapies><patient specific treatment><peer support><perinatal period><perinatal phase><post-partum><prevent><prevent relapse><preventing><relapse prevention><relapse risk><sleep disruption><sleep dysregulation><social><social attachment><social bonding><social role><social support network><statistics><stress buffering><stress management><stressor><substance use and disorder><tailored medical treatment><tailored therapy><tailored treatment><unique treatment><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

CHENG ZHANG

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 0/100
$156,500
FY 2021

Project Title

Structure and pharmacology of GPR32 in the resolution of inflammation

Grant Number:

1R03TR003306-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2021

End Date:

3/31/2022

Project Abstract

Project Summary Inflammation is a complex process with many lipid mediators involved. A large number of these mediators are eicosanoid lipids that promote either pro-inflammatory or pro-resolving effects through action on G protein- coupled receptors (GPCRs). These eicosanoid lipids share a high che...

Research Terms

<5,6,15-tri-HETE><5,6,15-triHETE><5,6,15-trihydroxy-7,9,11,13-eicosatetraenoic acid><ALXR><ARNT><ARNT gene><Address><Adopted><Agonist><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Antiinflammatories><Antiinflammatory Agents><Aryl Hydrocarbon Receptor Nuclear Translocator><Assay><Autoregulation><Binding><Bioassay><Biologic Assays><Biological Assay><Body Tissues><Cell Communication and Signaling><Cell Signaling><Chemicals><Complex><Cryo-electron Microscopy><Cryoelectron Microscopy><Crystallization><Development><Dioxin Receptor, Nuclear Translocator><Disease><Disorder><Drug Therapy><Drugs><Eicosanoids><Electron Cryomicroscopy><FPR2><FPR2 gene><FPRH1><FPRL1><Family><Formyl Peptide Receptor 2><Formyl Peptide Receptor Homolog 1><Formyl Peptide Receptor-Like 1><Foundations><Funding><Future><G Protein-Complex Receptor><G Protein-Coupled Receptor 32><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><GPCR><GPR32><GPR32 gene><Genetics-Mutagenesis><Genome><HIF-1 Beta Gene><HIF-1Beta Gene><HIF-1beta><HIF1-Beta Gene><HIF1B><HIF1B Gene><HIF1Beta><HIF1beta Gene><HM63><Homeostasis><Hypoxia-Inducible Factor 1 Beta Gene><Hypoxia-Inducible Factor 1, Beta subunit><Inflammation><Inflammatory><Intracellular Communication and Signaling><Investigation><Knowledge><LXA4><LXA4R><Ligands><Lipid Binding><Lipids><Lipoxin A4 Receptor><Lipoxins><Mediator><Mediator of Activation><Mediator of activation protein><Medication><Modeling><Molecular><Molecular Interaction><Mutagenesis><Mutagenesis Molecular Biology><Negative Staining><Nuclear Translocator Gene Dioxin Receptor><Orphan><PGD2><Pharmaceutic Preparations><Pharmaceutical Preparations><Pharmacology><Pharmacotherapy><Phylogenetic Analysis><Phylogenetics><Physiological Homeostasis><Physiology><Play><Preparation><Process><Prostaglandin D2><Prostaglandin Receptor><Prostaglandins><Prostanoids><Publishing><Receptor Protein><Receptor Signaling><Reporting><Research><Resolution><Role><Sampling><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Solid><Structural Models><Structure><System><TANGO><Testing><Therapeutic><Tissues><Viral Respiratory Tract Infection><Work><antiinflammatory><base><biological signal transduction><combat><cryo-EM><cryoEM><cytokine release syndrome><cytokine storm><developmental><drug candidate><drug development><drug treatment><drug/agent><frontier><improved><lipid bound><lipid mediator><lipoxin A4><new drug class><new drug treatments><new drugs><new therapeutics><new therapy><next generation therapeutics><novel><novel drug class><novel drug treatments><novel drugs><novel therapeutics><novel therapy><programs><receptor><restoration><social role><structural biology><success><tool><viral respiratory infection><virtual screening><virtual screenings>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

PAUL J ARCIERO

IPACES, LLC, CLIFTON PARK, NY

Exploratory lead · 0/100
$50,000
FY 2022

Project Title

Neuro-exergaming for the prevention and remediation of decline due to Alzheimer's disease and related dementias: A clinical trial of the interactive Physical and Cognitive Exercise System (iPACES v3)

Grant Number:

3R44AG071063-02S2

Activity Code:

R44

Mechanism:

SBIR/STTR

Agency:

NIH

Start Date:

9/30/2020

End Date:

5/31/2024

Project Abstract

Project Summary/Abstract (30 lines) We are pleased to submit this technical and business assistance (TABA) funding as an administrative supplement to our on-going DP2 SBIR: “Neuro-exergaming for the prevention and remediation of decline due to Alzheimer's disease and related dementias: A clinical t...

Research Terms

<AD related dementia><ADRD><Administrative Supplement><Adoption><Alzheimer related dementia><Alzheimer's disease related dementia><Attention><Award><Businesses><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 public health crisis><COVID19 crisis><COVID19 epidemic><COVID19 global health crisis><COVID19 global pandemic><COVID19 health crisis><COVID19 pandemic><COVID19 public health crisis><Clinical Trials><Code><Coding System><Cognitive><Consultations><Data><Development><Development and Research><Elderly><Exercise><FDA approved><Funding><Healthcare><Home><Insurance><Intellectual Property><Intervention><Intervention Strategies><Legal patent><Licensing><Light><Neuropsychologies><Neuropsychology><Occupational Therapy><Outcome><Patents><Phase><Photoradiation><Physiatric Procedure><Physical Medicine Procedure><Physical Phenomena or Properties><Physical Therapeutics><Physical therapy><Physicians><Physiotherapy><Play><Prevention><Publishing><R & D><R&D><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-CoV2 epidemic><SARS-CoV2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SBIR><Secure><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Small Business Innovation Research><Small Business Innovation Research Grant><System><Tablets><Update><Video Games><advanced age><base><cognitive assessment><cognitive benefits><cognitive process><cognitive testing><cognitive training><commercialization><corona virus disease 2019 epidemic><corona virus disease 2019 pandemic><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><developmental><digital health><elders><exergame><geriatric><health care><interventional strategy><invention><late life><later life><mild cognitive disorder><mild cognitive impairment><neuropathology><neuropsychologic><older adult><older person><physical process><pilot trial><remediation><research and development><residence><residential building><residential site><senior citizen><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><telehealth><videogame>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Cay Anderson-Hanley

IPACES, LLC, CLIFTON PARK, NY

Exploratory lead · 0/100
$50,000
FY 2022

Project Title

Neuro-exergaming for the prevention and remediation of decline due to Alzheimer's disease and related dementias: A clinical trial of the interactive Physical and Cognitive Exercise System (iPACES v3)

Grant Number:

3R44AG071063-02S2

Activity Code:

R44

Mechanism:

SBIR/STTR

Agency:

NIH

Start Date:

9/30/2020

End Date:

5/31/2024

Project Abstract

Project Summary/Abstract (30 lines) We are pleased to submit this technical and business assistance (TABA) funding as an administrative supplement to our on-going DP2 SBIR: “Neuro-exergaming for the prevention and remediation of decline due to Alzheimer's disease and related dementias: A clinical t...

Research Terms

<AD related dementia><ADRD><Administrative Supplement><Adoption><Alzheimer related dementia><Alzheimer's disease related dementia><Attention><Award><Businesses><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 public health crisis><COVID19 crisis><COVID19 epidemic><COVID19 global health crisis><COVID19 global pandemic><COVID19 health crisis><COVID19 pandemic><COVID19 public health crisis><Clinical Trials><Code><Coding System><Cognitive><Consultations><Data><Development><Development and Research><Elderly><Exercise><FDA approved><Funding><Healthcare><Home><Insurance><Intellectual Property><Intervention><Intervention Strategies><Legal patent><Licensing><Light><Neuropsychologies><Neuropsychology><Occupational Therapy><Outcome><Patents><Phase><Photoradiation><Physiatric Procedure><Physical Medicine Procedure><Physical Phenomena or Properties><Physical Therapeutics><Physical therapy><Physicians><Physiotherapy><Play><Prevention><Publishing><R & D><R&D><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-CoV2 epidemic><SARS-CoV2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SBIR><Secure><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Small Business Innovation Research><Small Business Innovation Research Grant><System><Tablets><Update><Video Games><advanced age><base><cognitive assessment><cognitive benefits><cognitive process><cognitive testing><cognitive training><commercialization><corona virus disease 2019 epidemic><corona virus disease 2019 pandemic><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><developmental><digital health><elders><exergame><geriatric><health care><interventional strategy><invention><late life><later life><mild cognitive disorder><mild cognitive impairment><neuropathology><neuropsychologic><older adult><older person><physical process><pilot trial><remediation><research and development><residence><residential building><residential site><senior citizen><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><telehealth><videogame>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

John P. Arciero

IPACES, LLC, CLIFTON PARK, NY

Exploratory lead · 0/100
$50,000
FY 2022

Project Title

Neuro-exergaming for the prevention and remediation of decline due to Alzheimer's disease and related dementias: A clinical trial of the interactive Physical and Cognitive Exercise System (iPACES v3)

Grant Number:

3R44AG071063-02S2

Activity Code:

R44

Mechanism:

SBIR/STTR

Agency:

NIH

Start Date:

9/30/2020

End Date:

5/31/2024

Project Abstract

Project Summary/Abstract (30 lines) We are pleased to submit this technical and business assistance (TABA) funding as an administrative supplement to our on-going DP2 SBIR: “Neuro-exergaming for the prevention and remediation of decline due to Alzheimer's disease and related dementias: A clinical t...

Research Terms

<AD related dementia><ADRD><Administrative Supplement><Adoption><Alzheimer related dementia><Alzheimer's disease related dementia><Attention><Award><Businesses><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 public health crisis><COVID19 crisis><COVID19 epidemic><COVID19 global health crisis><COVID19 global pandemic><COVID19 health crisis><COVID19 pandemic><COVID19 public health crisis><Clinical Trials><Code><Coding System><Cognitive><Consultations><Data><Development><Development and Research><Elderly><Exercise><FDA approved><Funding><Healthcare><Home><Insurance><Intellectual Property><Intervention><Intervention Strategies><Legal patent><Licensing><Light><Neuropsychologies><Neuropsychology><Occupational Therapy><Outcome><Patents><Phase><Photoradiation><Physiatric Procedure><Physical Medicine Procedure><Physical Phenomena or Properties><Physical Therapeutics><Physical therapy><Physicians><Physiotherapy><Play><Prevention><Publishing><R & D><R&D><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-CoV2 epidemic><SARS-CoV2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SBIR><Secure><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Small Business Innovation Research><Small Business Innovation Research Grant><System><Tablets><Update><Video Games><advanced age><base><cognitive assessment><cognitive benefits><cognitive process><cognitive testing><cognitive training><commercialization><corona virus disease 2019 epidemic><corona virus disease 2019 pandemic><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><developmental><digital health><elders><exergame><geriatric><health care><interventional strategy><invention><late life><later life><mild cognitive disorder><mild cognitive impairment><neuropathology><neuropsychologic><older adult><older person><physical process><pilot trial><remediation><research and development><residence><residential building><residential site><senior citizen><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><telehealth><videogame>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Mina Dunnam

IPACES, LLC, CLIFTON PARK, NY

Exploratory lead · 0/100
$50,000
FY 2022

Project Title

Neuro-exergaming for the prevention and remediation of decline due to Alzheimer's disease and related dementias: A clinical trial of the interactive Physical and Cognitive Exercise System (iPACES v3)

Grant Number:

3R44AG071063-02S2

Activity Code:

R44

Mechanism:

SBIR/STTR

Agency:

NIH

Start Date:

9/30/2020

End Date:

5/31/2024

Project Abstract

Project Summary/Abstract (30 lines) We are pleased to submit this technical and business assistance (TABA) funding as an administrative supplement to our on-going DP2 SBIR: “Neuro-exergaming for the prevention and remediation of decline due to Alzheimer's disease and related dementias: A clinical t...

Research Terms

<AD related dementia><ADRD><Administrative Supplement><Adoption><Alzheimer related dementia><Alzheimer's disease related dementia><Attention><Award><Businesses><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 public health crisis><COVID19 crisis><COVID19 epidemic><COVID19 global health crisis><COVID19 global pandemic><COVID19 health crisis><COVID19 pandemic><COVID19 public health crisis><Clinical Trials><Code><Coding System><Cognitive><Consultations><Data><Development><Development and Research><Elderly><Exercise><FDA approved><Funding><Healthcare><Home><Insurance><Intellectual Property><Intervention><Intervention Strategies><Legal patent><Licensing><Light><Neuropsychologies><Neuropsychology><Occupational Therapy><Outcome><Patents><Phase><Photoradiation><Physiatric Procedure><Physical Medicine Procedure><Physical Phenomena or Properties><Physical Therapeutics><Physical therapy><Physicians><Physiotherapy><Play><Prevention><Publishing><R & D><R&D><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-CoV2 epidemic><SARS-CoV2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SBIR><Secure><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Small Business Innovation Research><Small Business Innovation Research Grant><System><Tablets><Update><Video Games><advanced age><base><cognitive assessment><cognitive benefits><cognitive process><cognitive testing><cognitive training><commercialization><corona virus disease 2019 epidemic><corona virus disease 2019 pandemic><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><developmental><digital health><elders><exergame><geriatric><health care><interventional strategy><invention><late life><later life><mild cognitive disorder><mild cognitive impairment><neuropathology><neuropsychologic><older adult><older person><physical process><pilot trial><remediation><research and development><residence><residential building><residential site><senior citizen><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><telehealth><videogame>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

David Arthur Merrill

IPACES, LLC, CLIFTON PARK, NY

Exploratory lead · 0/100
$50,000
FY 2022

Project Title

Neuro-exergaming for the prevention and remediation of decline due to Alzheimer's disease and related dementias: A clinical trial of the interactive Physical and Cognitive Exercise System (iPACES v3)

Grant Number:

3R44AG071063-02S2

Activity Code:

R44

Mechanism:

SBIR/STTR

Agency:

NIH

Start Date:

9/30/2020

End Date:

5/31/2024

Project Abstract

Project Summary/Abstract (30 lines) We are pleased to submit this technical and business assistance (TABA) funding as an administrative supplement to our on-going DP2 SBIR: “Neuro-exergaming for the prevention and remediation of decline due to Alzheimer's disease and related dementias: A clinical t...

Research Terms

<AD related dementia><ADRD><Administrative Supplement><Adoption><Alzheimer related dementia><Alzheimer's disease related dementia><Attention><Award><Businesses><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 public health crisis><COVID19 crisis><COVID19 epidemic><COVID19 global health crisis><COVID19 global pandemic><COVID19 health crisis><COVID19 pandemic><COVID19 public health crisis><Clinical Trials><Code><Coding System><Cognitive><Consultations><Data><Development><Development and Research><Elderly><Exercise><FDA approved><Funding><Healthcare><Home><Insurance><Intellectual Property><Intervention><Intervention Strategies><Legal patent><Licensing><Light><Neuropsychologies><Neuropsychology><Occupational Therapy><Outcome><Patents><Phase><Photoradiation><Physiatric Procedure><Physical Medicine Procedure><Physical Phenomena or Properties><Physical Therapeutics><Physical therapy><Physicians><Physiotherapy><Play><Prevention><Publishing><R & D><R&D><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-CoV2 epidemic><SARS-CoV2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SBIR><Secure><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Small Business Innovation Research><Small Business Innovation Research Grant><System><Tablets><Update><Video Games><advanced age><base><cognitive assessment><cognitive benefits><cognitive process><cognitive testing><cognitive training><commercialization><corona virus disease 2019 epidemic><corona virus disease 2019 pandemic><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><developmental><digital health><elders><exergame><geriatric><health care><interventional strategy><invention><late life><later life><mild cognitive disorder><mild cognitive impairment><neuropathology><neuropsychologic><older adult><older person><physical process><pilot trial><remediation><research and development><residence><residential building><residential site><senior citizen><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><telehealth><videogame>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

STELLA E PANOS

IPACES, LLC, CLIFTON PARK, NY

Exploratory lead · 0/100
$50,000
FY 2022

Project Title

Neuro-exergaming for the prevention and remediation of decline due to Alzheimer's disease and related dementias: A clinical trial of the interactive Physical and Cognitive Exercise System (iPACES v3)

Grant Number:

3R44AG071063-02S2

Activity Code:

R44

Mechanism:

SBIR/STTR

Agency:

NIH

Start Date:

9/30/2020

End Date:

5/31/2024

Project Abstract

Project Summary/Abstract (30 lines) We are pleased to submit this technical and business assistance (TABA) funding as an administrative supplement to our on-going DP2 SBIR: “Neuro-exergaming for the prevention and remediation of decline due to Alzheimer's disease and related dementias: A clinical t...

Research Terms

<AD related dementia><ADRD><Administrative Supplement><Adoption><Alzheimer related dementia><Alzheimer's disease related dementia><Attention><Award><Businesses><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 public health crisis><COVID19 crisis><COVID19 epidemic><COVID19 global health crisis><COVID19 global pandemic><COVID19 health crisis><COVID19 pandemic><COVID19 public health crisis><Clinical Trials><Code><Coding System><Cognitive><Consultations><Data><Development><Development and Research><Elderly><Exercise><FDA approved><Funding><Healthcare><Home><Insurance><Intellectual Property><Intervention><Intervention Strategies><Legal patent><Licensing><Light><Neuropsychologies><Neuropsychology><Occupational Therapy><Outcome><Patents><Phase><Photoradiation><Physiatric Procedure><Physical Medicine Procedure><Physical Phenomena or Properties><Physical Therapeutics><Physical therapy><Physicians><Physiotherapy><Play><Prevention><Publishing><R & D><R&D><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-CoV2 epidemic><SARS-CoV2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SBIR><Secure><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Small Business Innovation Research><Small Business Innovation Research Grant><System><Tablets><Update><Video Games><advanced age><base><cognitive assessment><cognitive benefits><cognitive process><cognitive testing><cognitive training><commercialization><corona virus disease 2019 epidemic><corona virus disease 2019 pandemic><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><developmental><digital health><elders><exergame><geriatric><health care><interventional strategy><invention><late life><later life><mild cognitive disorder><mild cognitive impairment><neuropathology><neuropsychologic><older adult><older person><physical process><pilot trial><remediation><research and development><residence><residential building><residential site><senior citizen><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><telehealth><videogame>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Emilie Saulnier

IPACES, LLC, CLIFTON PARK, NY

Exploratory lead · 0/100
$50,000
FY 2022

Project Title

Neuro-exergaming for the prevention and remediation of decline due to Alzheimer's disease and related dementias: A clinical trial of the interactive Physical and Cognitive Exercise System (iPACES v3)

Grant Number:

3R44AG071063-02S2

Activity Code:

R44

Mechanism:

SBIR/STTR

Agency:

NIH

Start Date:

9/30/2020

End Date:

5/31/2024

Project Abstract

Project Summary/Abstract (30 lines) We are pleased to submit this technical and business assistance (TABA) funding as an administrative supplement to our on-going DP2 SBIR: “Neuro-exergaming for the prevention and remediation of decline due to Alzheimer's disease and related dementias: A clinical t...

Research Terms

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Search NIH grants by PI name

Looking for a specific principal investigator? The keyword search above looks up funded projects by topic. To search NIH grants by PI name (last name, first + last name, or partial name) and see every active and recent NIH award for that researcher, use the dedicated PI Funding Status tool.

How to Use PI Funding Data for Career Decisions

Finding the right principal investigator is one of the most important decisions in an academic career. Whether you are a postdoc looking for a mentor, a graduate student choosing a rotation lab, or a collaborator seeking a co-PI, NIH funding data provides objective signals about which investigators have active research programs and resources to support new team members.

A PI with a recently awarded R01 or equivalent grant is more likely to have budget for new personnel than one whose funding ended two years ago. The activity code tells you the type of grant: R01 and R35 awards typically support multiple lab members, while K-series awards are individual career development grants that may not fund additional positions. Understanding these distinctions helps you interpret search results accurately.

Look beyond the dollar amount. A $500,000 per year R01 at a high-cost institution may support fewer positions than a $300,000 award at a university with lower overhead rates. The project abstract and public health relevance statement reveal whether the PI's research direction aligns with your interests and expertise.

Understanding PI Grant Portfolios

A PI's grant portfolio reveals more than individual awards. Investigators with multiple active grants often run larger labs with more diverse projects, which can mean more opportunities for trainees. However, a PI with a single well-funded grant may offer more focused mentorship and a clearer path to publications.

Multi-PI grants (those with more than one principal investigator listed) indicate collaborative research and may involve trainees from multiple institutions. These can be excellent opportunities for interdisciplinary training but may also mean split attention from any single mentor.

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Frequently Asked Questions About PI Search

What does the opportunity score mean?

The opportunity score is a heuristic that combines award recency, funding amount, activity code type, and project characteristics to estimate how actionable a result might be for job seekers or collaborators. Higher scores suggest stronger signals, but always verify by reading the abstract and checking the PI's current lab page.

Why can't I find a PI I know has funding?

Name variations are the most common cause. Try searching with just the last name, or use different formats like "Smith, John" versus "John Smith." Some PIs also publish under different name variations or may have awards under a previous institutional affiliation.

Does this tool show all NIH-funded PIs?

The tool searches NIH RePORTER data for the keyword and year range you specify. It returns PIs whose funded projects match your search terms. PIs with grants in unrelated areas or whose projects use different terminology will not appear in keyword-filtered results.

What is the difference between "Likely hiring" and "Training-friendly" filters?

"Likely hiring" flags PIs with large new awards or activity codes typically associated with lab expansion. "Training-friendly" identifies awards that include training components or are at institutions known for postdoctoral programs. Both are heuristic filters to help prioritize your outreach.

How to use this well

Start broad, then narrow. Search a field first, then refine by timeframe once you understand who is currently active.

After you find a promising PI, cross-check them in Check PI Funding and review their institution, mechanism type, and project abstracts before reaching out.

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Use the abstract, award year, mechanism, and organization context to decide whether the record is strategically relevant.

Data limits

NIH records can lag, institutional names can vary, and some investigators publish or file awards under multiple name formats.

For details on source coverage and refresh cadence, read Data & Methodology.

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Recently Funded Labs in Trending Areas

Principal investigators who received NIH awards in the last 90 days, organized by research area. Use this as a starting point for postdoc searches, collaborator outreach, or competitor scans. Counts and labs refresh daily.

Alzheimer's disease

Neurodegeneration, biomarkers, and disease-modifying therapies.

  • Carlos Cruchaga — WASHINGTON UNIVERSITY, MO
    CONGAS: "Caribbean Omics 'N' Genomics for Alzheimer Study"
    $101,153 · awarded Feb 25, 2026 · 3U01AG084514-01A1S1
  • Carlos Cruchaga — WASHINGTON UNIVERSITY, MO
    CONGAS: "Caribbean Omics 'N' Genomics for Alzheimer Study"
    $3,086,339 · awarded Feb 19, 2026 · 1U01AG084514-01A1
  • HARALD SONTHEIMER — UNIVERSITY OF VIRGINIA, VA
    Extracellular matrix and memory impairments in Alzheimer disease
    $709,066 · awarded Apr 7, 2026 · 5R01AG085359-03
  • Keith Josephs — MAYO CLINIC ROCHESTER, MN
    The neurobiology of two distinct subtypes of neurodegenerative apraxia of speech: phenotypes of Alzheimer disease related 4-repeat tauopathies
    $643,670 · awarded Apr 1, 2026 · 5R01DC014942-09
  • DMITRIY YABLONSKIY — WASHINGTON UNIVERSITY, MO
    Deep-Learning-Augmented Quantitative Gradient Recalled Echo (DLA-qGRE) MRI for in vivo Clinical Evaluation of Brain Microstructural Neurodegeneration in Alzheimer Disease
    $661,985 · awarded Mar 3, 2026 · 4R01AG082030-02
Search more PIs in Alzheimer's disease →

CRISPR & gene editing

Therapeutic gene editing, base editing, and prime editing.

  • Changchun Liu — UNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT
    Asymmetric CRISPR Approach for Nucleic Acid Quantification
    $643,849 · awarded Mar 30, 2026 · 2R01EB023607-06A1
  • William Pu — BOSTON CHILDREN'S HOSPITAL, MA
    A modular system for murine CRISPR genome and epigenome editing
    $267,000 · awarded Mar 27, 2026 · 5R21OD037909-02
  • Naama Aviram — SLOAN-KETTERING INST CAN RESEARCH, NY
    Molecular mechanisms of memory formation and tolerance in CRISPR-Cas systems
    $249,000 · awarded Apr 2, 2026 · 5R00GM148720-04
  • Mats Ljungman — UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI
    Precision targeting of bladder cancer using CRISPR
    $582,849 · awarded Feb 17, 2026 · 5R01CA285730-03
  • Shannon Miller — SCRIPPS RESEARCH INSTITUTE, THE, CA
    Development of potent and safe CRISPR tools for in vivo gene editing using directed evolution
    $230,000 · awarded May 5, 2026 · 5R21EB036298-03
Search more PIs in CRISPR & gene editing →

Cancer immunotherapy

Checkpoint inhibitors, CAR-T, TIL therapy, and beyond.

  • TERRY SHEPPARD — KEYSTONE SYMPOSIA, CO
    Cancer Immunotherapy: Basic Mechanisms Informing Clinical Applications & Combinations
    $5,000 · awarded Mar 3, 2026 · 1R13CA310704-01
  • Veronika Fedirko — UNIVERSITY OF TX MD ANDERSON CAN CTR, TX
    Gut Microbiome and Cancer Immunotherapy Outcomes in Advanced Renal Cell Carcinoma
    $927,329 · awarded Mar 3, 2026 · 5R01CA255322-05
  • Yuwen Zhu — UNIVERSITY OF COLORADO DENVER, CO
    The GPR171 pathway in cancer immunotherapy
    $355,706 · awarded Apr 2, 2026 · 5R01CA279398-04
  • ANDREW WIEMER — UNIVERSITY OF CONNECTICUT STORRS, CT
    Synthesis and evaluation of BTN3A1 ligands for cancer immunotherapy
    $374,171 · awarded May 1, 2026 · 5R01CA266138-05
  • Wei Hu — YALE UNIVERSITY, CT
    Novel Treg inactivating approach for cancer immunotherapy via targeted protein degradation
    $482,312 · awarded Apr 6, 2026 · 1R01CA295942-01A1
Search more PIs in Cancer immunotherapy →

GLP-1 & metabolic disease

Diabetes, obesity, and weight-loss therapeutic mechanisms.

  • ZHIPING PANG — RUTGERS BIOMEDICAL AND HEALTH SCIENCES, NJ
    Synaptic and circuit mechanisms of central GLP-1 signaling in energy balance
    $479,051 · awarded Apr 23, 2026 · 5R01DK131452-05
  • Madhusmita Misra — UNIVERSITY OF VIRGINIA, VA
    Bone metabolism in adolescents undergoing GLP-1 receptor agonist therapy
    $471,776 · awarded Apr 24, 2026 · 5R01HD118635-07
  • STEVEN SCHWENDEMAN — UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI
    Remote Loading of Melanocortin and GLP-1 Peptides in Polymers for Treatment of Obesity
    $231,000 · awarded Apr 17, 2026 · 1R56DK141545-01A1
  • Jessica Barson — DREXEL UNIVERSITY, PA
    Suppression of ethanol dependence-induced maladaptive appetitive and consummatory behavior by the GLP-1 system
    $564,306 · awarded May 5, 2026 · 1R01AA031732-01A1
  • MICHAEL CAMILLERI — MAYO CLINIC ROCHESTER, MN
    A Randomized, placebo-controlled trial of the effects of Long-Acting GLP-1 or Dual Incretin (GLP-1 and GIP) Modulation on Gastrointestinal Functions and Relationship to Weight Loss
    $322,800 · awarded Apr 9, 2026 · 5R01DK142606-02
Search more PIs in GLP-1 & metabolic disease →

Long COVID

Post-acute sequelae and chronic infection-driven illness.

  • Alexei Tumanov — UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, TX
    Lymphotoxin-dependent control of long COVID
    $234,715 · awarded Feb 13, 2026 · 1R21AI185790-01A1
  • Amal Amer — OHIO STATE UNIVERSITY, OH
    Role of the Non-canonical Inflammasome in SARS-CoV-2-mediated Pathology and Coagulopathy
    $2,974,582 · awarded Apr 21, 2026 · 5P01AI175399-03
  • Alba Azola — JOHNS HOPKINS UNIVERSITY, MD
    Blood-Brain Barrier Integrity and Immune Dynamics in Neuropsychiatric Sequelae of Post-SARS-CoV-2 onset ME/CFS versus Pre-Pandemic ME/CFS Patients
    $633,378 · awarded Apr 17, 2026 · 1R01NS147100-01
  • DANIELLE REED — MONELL CHEMICAL SENSES CENTER, PA
    Inflammation and chemosensory loss
    $2,654,249 · awarded Feb 26, 2026 · 1P50DC022549-01A1
  • Jarred Younger — UNIVERSITY OF ALABAMA AT BIRMINGHAM, AL
    Low-dose naltrexone (LDN) for the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
    $556,686 · awarded Mar 6, 2026 · 1UG3NS141843-01A1
Search more PIs in Long COVID →