NIH RFA · ORIP · R24

RFA-OD-25-010: Resource-Related Research Projects for Development of Models and Related Materials for Studying Human Health and Diseases (R24 Clinical Trials Not Allowed)

Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards

Open for applicationsNext due date: Jan 26, 2027Expires Sep 29, 2028

The Office of Research Infrastructure Programs (ORIP) encourages grant applications aimed at developing, characterizing, or improving research models of human health and diseases; developing biology based new approach methodologies (NAMs) applicable to human health and diseases; or improving access to information about or generated from the use of models of human disease. The models, including NAMs, and related biological materials developed must be broadly applicable to the scientific interests of two or more NIH Institutes or Centers (ICs) and must evaluate diseases and processes that impact multiple organ systems in order to align with the ORIP"s NIH-wide mission and programs.…

Full NOFO in the NIH Guide Apply on Grants.gov

NOFO number
RFA-OD-25-010
Type
RFA
Activity code
R24
Primary institute
ORIP
Clinical trials
Not Allowed
Posted
Dec 5, 2025
Opens
Dec 27, 2025
Expires
Sep 29, 2028

RFA-OD-25-010 due dates

6 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.

Application due dates and review cycles for RFA-OD-25-010
NewRenewal / Resubmission / Revision (as allowed)AIDS - New/Renewal/Resubmission/Revision, as allowedScientific Merit ReviewAdvisory Council ReviewEarliest Start Date
January 27, 2026January 27, 2026Not ApplicableJuly 2026October 2026December 2026
May 27, 2026May 27, 2026Not ApplicableNovember 2026January 2027April 2027
September 28, 2026September 28, 2026Not ApplicableMarch 2027May 2027July 2027
January 26, 2027January 26, 2027Not ApplicableJuly 2027October 2027December 2027
May 26, 2027May 26, 2027Not ApplicableNovember 2027January 2028April 2028
September 28, 2027September 28, 2027Not ApplicableMarch 2028May 2028July 2028
January 26, 2028January 26, 2028Not ApplicableJuly 2028October 2028December 2028
May 26, 2028May 26, 2028Not ApplicableNovember 2028January 2029April 2029
September 28, 2028September 28, 2028Not ApplicableMarch 2029May 2029July 2029

What its predecessor RFA-OD-22-013 funded

RFA-OD-25-010 reissues RFA-OD-22-013. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 31 projects and $51.2M in FY2022–FY2026.

Projects funded

31

Distinct projects, FY2022–FY2026

New awards

24

Type 1 (new project) award records

NIH funding

$51.2M

Award dollars under RFA-OD-22-013, FY2022–FY2026

Funding by fiscal year

Award records, new awards, and funding by fiscal year under RFA-OD-22-013
Fiscal yearAward recordsNew awardsFunding
FY202200$0
FY202322$1.7M
FY2024126$9.3M
FY2025217$16.1M
FY2026319$24.1M

Institutions with the most funding

  1. Iowa State University$4.5M · 2 projects
  2. Univ of Massachusetts Med Sch Worcester$4.3M · 2 projects
  3. Brigham and Women's Hospital$3.5M · 1 project
  4. Stanford University$3.0M · 1 project
  5. Pennsylvania State Univ Hershey Med Ctr$2.8M · 1 project
  6. Utah State Higher Education System--University of Utah$2.3M · 1 project
  7. Marine Biological Laboratory$2.3M · 1 project
  8. Arizona State University-Tempe Campus$2.3M · 1 project

Funding institutes

  • OD$51.2M · 66

Activity codes funded

  • R2466 records

Most recent new awards

FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.

Participating institutes

2 NIH institutes and offices take applications under RFA-OD-25-010. Contact the program officer at the institute that fits your research before applying.

  • ORIP
  • INCLD

Related notices

NIH lists no related notices for RFA-OD-25-010 yet.

Award terms

Application types allowed
New Renewal Resubmission Revision The OER Glossary and the How to Apply - Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
Award budget
Application budgets are not limited but need to reflect the actual needs of the proposed project.Applicants requesting 500,000 or more in direct costs in any year excluding consortium F&A) should refer to NOT-OD-23-075 and must contact a Scientific/ Research Contact for approval at least 6 weeks before submitting the new or renewal application.For Renewal a.k.a. Type 2) applications including…
Project period
The duration of the proposed project may not exceed four years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
Funds available and number of awards
Contingent upon NIH appropriations and the submission of meritorious applications, NIH intends to commit 5,000,000 per fiscal year in FY 2026-2029 to fund at least six awards per fiscal year, including Down Syndrome related awards if there are any.

Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.

Related NOFOs

  • Reissue of RFA-OD-22-013.

Other open NOFOs for R24

Browse all open NIH NOFOs

About this page

GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.

Find who wins under this NOFO

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